DE69206721D1 - Neues Verfahren zur Herstellung von Hydrocortison sowie Zwischenprodukten dafür - Google Patents

Neues Verfahren zur Herstellung von Hydrocortison sowie Zwischenprodukten dafür

Info

Publication number: DE69206721D1
Authority: DE; Germany
Prior art keywords: hydrocortisone; production; new process; intermediates therefor; intermediates
Prior art date: 1991-09-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69206721T

Other languages

English (en)

Other versions

DE69206721T2 (de

Inventor

Francis Brion

Jean Buendia

Christian Diolez

Michel Vivat

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Roussel Uclaf SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-06

Filing date

1992-09-03

Publication date

1996-01-25

1992-09-03 Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA

1996-01-25 Publication of DE69206721D1 publication Critical patent/DE69206721D1/de

1996-05-23 Application granted granted Critical

1996-05-23 Publication of DE69206721T2 publication Critical patent/DE69206721T2/de

2012-09-04 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C07J33/007—Cyclic thioketals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

DE69206721T 1991-09-06 1992-09-03 Neues Verfahren zur Herstellung von Hydrocortison sowie Zwischenprodukten dafür Expired - Lifetime DE69206721T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9111052A FR2681069B1 (fr)	1991-09-06	1991-09-06	Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.

Publications (2)

Publication Number	Publication Date
DE69206721D1 true DE69206721D1 (de)	1996-01-25
DE69206721T2 DE69206721T2 (de)	1996-05-23

Family

ID=9416716

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69206721T Expired - Lifetime DE69206721T2 (de)	1991-09-06	1992-09-03	Neues Verfahren zur Herstellung von Hydrocortison sowie Zwischenprodukten dafür

Country Status (20)

Country	Link
US (4)	US5260463A (de)
EP (1)	EP0531212B1 (de)
JP (1)	JP3466645B2 (de)
KR (1)	KR100220542B1 (de)
CN (1)	CN1035947C (de)
AT (1)	ATE131488T1 (de)
AU (1)	AU653841B2 (de)
CA (1)	CA2077625C (de)
DE (1)	DE69206721T2 (de)
DK (1)	DK0531212T3 (de)
ES (1)	ES2089449T3 (de)
FR (1)	FR2681069B1 (de)
GR (1)	GR3018402T3 (de)
HU (1)	HU212666B (de)
MX (1)	MX9205063A (de)
PL (5)	PL172040B1 (de)
RU (1)	RU2060257C1 (de)
TW (1)	TW269693B (de)
UA (1)	UA35556C2 (de)
ZA (1)	ZA925516B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2683530B1 (fr) *	1991-11-08	1994-01-21	Roussel Uclaf	Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
FR2691968B1 (fr) *	1992-06-04	1994-07-29	Roussel Uclaf	Nouveau procede de preparation d'un derive sterouide 11-ceto.
FR2719588B1 (fr) *	1994-05-03	1996-06-07	Roussel Uclaf	Nouveau procédé de préparation de la substance "S" et nouveaux intermédiaires.
FR2721927B1 (fr) *	1994-07-01	1996-08-09	Roussel Uclaf	Nouveau procede de preparation de derives steroides 20-oxo 17 alpha, 21-dihydroxyles et nouveaux intermediaires
US5929262A (en) *	1995-03-30	1999-07-27	The United States Of America As Represented By The Department Of Health And Human Services	Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
US6348324B1 (en)	1999-01-21	2002-02-19	Hypoguard America Limited	Composition and device for detecting leukocytes in urine
US6528652B1 (en)	1999-01-21	2003-03-04	Chronimed	Composition and device for detecting leukocytes in urine
US8990064B2 (en) *	2009-07-28	2015-03-24	Language Weaver, Inc.	Translating documents based on content

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2744110A (en) *	1954-04-22	1956-05-01	Searle & Co	3-ethylene mercaptole derivatives of progesterone
GB1089788A (en) *	1965-07-07	1967-11-08	Parke Davis & Co	Process for the production of steroidal lactone compounds and intermediates thereof
NL7607283A (nl) *	1975-07-23	1977-01-25	Merck & Co Inc	Werkwijze voor het bereiden van nieuwe pregnaansteroiden.
FR2344286A1 (fr) *	1976-03-16	1977-10-14	Roussel Uclaf	Nouveaux derives 17-spirosultines, les g-hydroxy acides correspondants, leur procede de preparation et leur application comme medicament
US5182381A (en) *	1982-03-01	1993-01-26	Roussel Ulcaf	Intermediates for 3-keto-19-nor-Δ4,9 -steroids
EP0123734A1 (de) *	1983-04-29	1984-11-07	Gist-Brocades N.V.	17-(Isocyano-sulfonylmethylen)-Steroide, 17-(Formamido-sulfonylmethylen)-Steroide und ihre Herstellung
GB8721384D0 (en) *	1987-09-11	1987-10-21	Erba Farmitalia	17-substituted andro-sta-1 4-dien-3-one derivatives
PT90227B (pt) *	1988-04-08	1994-06-30	Roussel Uclaf	Processo para a preparacao de esteroides de 9 alfa-hidroxi-17-metileno

1991
- 1991-09-06 FR FR9111052A patent/FR2681069B1/fr not_active Expired - Fee Related
1992
- 1992-07-22 ZA ZA925516A patent/ZA925516B/xx unknown
- 1992-07-23 TW TW081105829A patent/TW269693B/zh not_active IP Right Cessation
- 1992-07-27 AU AU20570/92A patent/AU653841B2/en not_active Expired
- 1992-08-21 RU SU925052452A patent/RU2060257C1/ru active
- 1992-08-25 JP JP24713992A patent/JP3466645B2/ja not_active Expired - Lifetime
- 1992-08-25 US US07/935,535 patent/US5260463A/en not_active Expired - Lifetime
- 1992-09-03 DK DK92402406.0T patent/DK0531212T3/da active
- 1992-09-03 AT AT92402406T patent/ATE131488T1/de active
- 1992-09-03 MX MX9205063A patent/MX9205063A/es unknown
- 1992-09-03 ES ES92402406T patent/ES2089449T3/es not_active Expired - Lifetime
- 1992-09-03 EP EP92402406A patent/EP0531212B1/de not_active Expired - Lifetime
- 1992-09-03 DE DE69206721T patent/DE69206721T2/de not_active Expired - Lifetime
- 1992-09-04 PL PL92295836A patent/PL172040B1/pl unknown
- 1992-09-04 HU HU9202851A patent/HU212666B/hu unknown
- 1992-09-04 PL PL92315568A patent/PL172809B1/pl unknown
- 1992-09-04 PL PL92319638A patent/PL173272B1/pl unknown
- 1992-09-04 CA CA002077625A patent/CA2077625C/fr not_active Expired - Lifetime
- 1992-09-04 PL PL92315567A patent/PL173589B1/pl unknown
- 1992-09-04 PL PL92315569A patent/PL172822B1/pl unknown
- 1992-09-05 CN CN92110286A patent/CN1035947C/zh not_active Expired - Lifetime
- 1992-09-05 KR KR1019920016242A patent/KR100220542B1/ko not_active IP Right Cessation
1993
- 1993-06-18 UA UA93002997A patent/UA35556C2/uk unknown
- 1993-08-12 US US08/105,742 patent/US5401840A/en not_active Expired - Lifetime
1994
- 1994-12-22 US US08/362,120 patent/US5502182A/en not_active Expired - Lifetime
1995
- 1995-10-02 US US08/538,027 patent/US5556962A/en not_active Expired - Lifetime
- 1995-12-14 GR GR950401070T patent/GR3018402T3/el unknown

Also Published As

Publication number	Publication date
EP0531212A2 (de)	1993-03-10
ZA925516B (en)	1993-07-22
US5260463A (en)	1993-11-09
US5401840A (en)	1995-03-28
JP3466645B2 (ja)	2003-11-17
CN1070196A (zh)	1993-03-24
US5502182A (en)	1996-03-26
MX9205063A (es)	1993-05-01
KR100220542B1 (ko)	1999-10-01
PL172040B1 (pl)	1997-07-31
CA2077625A1 (fr)	1993-03-07
RU2060257C1 (ru)	1996-05-20
EP0531212B1 (de)	1995-12-13
FR2681069A1 (fr)	1993-03-12
PL172822B1 (en)	1997-11-28
AU2057092A (en)	1993-03-11
AU653841B2 (en)	1994-10-13
CN1035947C (zh)	1997-09-24
JPH05194581A (ja)	1993-08-03
UA35556C2 (uk)	2001-04-16
TW269693B (de)	1996-02-01
CA2077625C (fr)	2003-10-28
HUT62598A (en)	1993-05-28
HU212666B (en)	1996-09-30
HU9202851D0 (en)	1992-11-30
DK0531212T3 (da)	1997-03-03
US5556962A (en)	1996-09-17
GR3018402T3 (en)	1996-03-31
PL295836A1 (en)	1993-05-17
ES2089449T3 (es)	1996-10-01
PL172809B1 (pl)	1997-11-28
PL173272B1 (pl)	1998-02-27
DE69206721T2 (de)	1996-05-23
ATE131488T1 (de)	1995-12-15
EP0531212A3 (en)	1993-05-26
PL173589B1 (pl)	1998-03-31
KR930006048A (ko)	1993-04-20
FR2681069B1 (fr)	1995-04-28

Legal Events

Date	Code	Title	Description
1997-01-16	8364	No opposition during term of opposition
2000-03-30	8327	Change in the person/name/address of the patent owner	Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR
2005-02-24	8327	Change in the person/name/address of the patent owner	Owner name: AVENTIS PHARMA S.A., ANTONY, FR
2006-10-26	8328	Change in the person/name/address of the agent	Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN
2009-07-30	8328	Change in the person/name/address of the agent	Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC
2012-09-04	R071	Expiry of right	Ref document number: 531212 Country of ref document: EP

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