DE69226064D1 - Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel - Google Patents

Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel

Info

Publication number
DE69226064D1
DE69226064D1 DE69226064T DE69226064T DE69226064D1 DE 69226064 D1 DE69226064 D1 DE 69226064D1 DE 69226064 T DE69226064 T DE 69226064T DE 69226064 T DE69226064 T DE 69226064T DE 69226064 D1 DE69226064 D1 DE 69226064D1
Authority
DE
Germany
Prior art keywords
solvent
precipitation
production
protein microparticles
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226064T
Other languages
English (en)
Other versions
DE69226064T2 (de
DE69226064T3 (de
Inventor
Pablo G Debenedetti
Gio-Bin Lim
Homme Robert K Prud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25156397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69226064(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Princeton University filed Critical Princeton University
Application granted granted Critical
Publication of DE69226064D1 publication Critical patent/DE69226064D1/de
Publication of DE69226064T2 publication Critical patent/DE69226064T2/de
Publication of DE69226064T3 publication Critical patent/DE69226064T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/98—Preparation of granular or free-flowing enzyme compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/141—Feedstock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
DE69226064T 1991-11-14 1992-11-13 Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel Expired - Fee Related DE69226064T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US792292 1991-11-14
US07/792,292 US6063910A (en) 1991-11-14 1991-11-14 Preparation of protein microparticles by supercritical fluid precipitation

Publications (3)

Publication Number Publication Date
DE69226064D1 true DE69226064D1 (de) 1998-08-06
DE69226064T2 DE69226064T2 (de) 1998-10-29
DE69226064T3 DE69226064T3 (de) 2005-07-07

Family

ID=25156397

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226064T Expired - Fee Related DE69226064T3 (de) 1991-11-14 1992-11-13 Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel

Country Status (9)

Country Link
US (1) US6063910A (de)
EP (1) EP0542314B9 (de)
JP (1) JP3342899B2 (de)
AT (1) ATE167870T1 (de)
AU (1) AU668367B2 (de)
CA (1) CA2083027C (de)
DE (1) DE69226064T3 (de)
DK (1) DK0542314T4 (de)
ES (1) ES2118778T5 (de)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9400079B (sl) * 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
AU709262B2 (en) * 1995-10-17 1999-08-26 Board Of Regents, The University Of Texas System Insoluble drug delivery
US5833891A (en) * 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
FR2753639B1 (fr) 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) * 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
DE19711393C1 (de) * 1997-03-19 1998-08-13 Fraunhofer Ges Forschung Verfahren zum Mikroverkapseln von Partikeln
US6541606B2 (en) * 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
GB9806462D0 (en) * 1998-03-26 1998-05-27 Glaxo Group Ltd Improved compositions for inhalation
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US6451349B1 (en) 1998-08-19 2002-09-17 Quadrant Healthcare (Uk) Limited Spray-drying process for the preparation of microparticles
GB9814172D0 (en) * 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
US6051694A (en) * 1998-09-17 2000-04-18 Castor; Trevor Percival Method for size reduction of proteins
SE9804001D0 (sv) † 1998-11-23 1998-11-23 Astra Ab New process
US6630121B1 (en) 1999-06-09 2003-10-07 The Regents Of The University Of Colorado Supercritical fluid-assisted nebulization and bubble drying
PT1808438E (pt) * 1999-06-29 2015-01-14 Mannkind Corp Purificação e estabilização de péptidos e proteínas em agentes farmacêuticos
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
EP1194127B1 (de) * 1999-07-13 2004-11-10 Degussa AG Verfahren zur herstellung pulverförmiger partikelreduzierter formulierungen mit hilfe verdichteter gase
FR2803538B1 (fr) * 1999-12-15 2002-06-07 Separex Sa Procede et dispositif de captage de fines particules par percolation dans un lit de granules
FR2802445B1 (fr) * 1999-12-15 2002-02-15 Separex Sa Procede et dispositif de captage de fines particules par piegeage au sein d'un melange solide de type neige carbonique
US6761909B1 (en) * 1999-12-21 2004-07-13 Rxkinetix, Inc. Particulate insulin-containing products and method of manufacture
WO2001045731A1 (en) * 1999-12-21 2001-06-28 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
US6620351B2 (en) 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
US6821413B1 (en) * 2000-08-31 2004-11-23 Fluidphase Technologies, Inc. Method and apparatus for continuous separation and reaction using supercritical fluid
US6562952B1 (en) * 2000-10-31 2003-05-13 The University Of Kansas Precipitation of proteins from organic solutions
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
AUPR197000A0 (en) * 2000-12-08 2001-01-11 Unisearch Limited Synthesis of small particles
US6607784B2 (en) * 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
EP1354581A4 (de) * 2000-12-26 2007-07-04 Takeda Pharmaceutical Poröse substanz und verfahren zu ihrer herstellung
EP1345968A2 (de) * 2000-12-28 2003-09-24 Altus Biologics Inc. Kristalle ganzer antikörper und fragmente davon und verfahren zu ihrer herstellung und verwendung
US7708915B2 (en) * 2004-05-06 2010-05-04 Castor Trevor P Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
ES2223034T3 (es) * 2001-02-26 2005-02-16 Dompe S.P.A. Aparato y metodo para la formacion de particulas micronicas y submicronicas.
US6869551B2 (en) 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
US6596206B2 (en) 2001-03-30 2003-07-22 Picoliter Inc. Generation of pharmaceutical agent particles using focused acoustic energy
WO2003000014A2 (en) 2001-06-21 2003-01-03 Altus Biologics, Inc. Spherical protein particles and methods of making and using them
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
IL160570A0 (en) * 2001-09-26 2004-07-25 Baxter Int Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP2005511521A (ja) * 2001-10-10 2005-04-28 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 加圧ガス状流体による粉末処理
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
MXPA04003718A (es) * 2001-10-22 2004-07-30 Dompe Spa Procesamiento de fluidos supercriticos: preparacion de microparticulas de proteina y su estabilizacion.
JP2005514188A (ja) * 2001-12-07 2005-05-19 エイフェル テクノロジーズ リミテッド 小粒子の合成
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
KR20050011741A (ko) * 2002-04-11 2005-01-29 메드이뮨 백신즈 인코포레이티드 분무 건조에 의한 생물학적 활성 물질의 보존
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
EP1624862B1 (de) * 2003-05-08 2014-12-31 Nektar Therapeutics Teilchenförmige materialien
WO2004108265A2 (en) 2003-06-03 2004-12-16 Ferro Corporation Nanoparticles from supercritical fluid antisolvent process using particle growth and agglomeration retardants
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
MXPA06000720A (es) * 2003-07-18 2006-08-23 Baxter Int Metodos para fabricacion, usos y composiciones de particulas esfericas pequenas preparadas por separacion de fase controlada.
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
EP1646354A4 (de) * 2003-07-22 2010-03-17 Baxter Int Kleine kugelförmige teilchen von niedermolekularen organischen molekülen und herstellungs- und anwendungsverfahren dafür
JP2007505136A (ja) * 2003-09-10 2007-03-08 マツプ・フアーマシユーテイカルズ・インコーポレーテツド ジヒドロエルゴタミンを肺吸入により体循環に送達するためのエアゾール製剤
US7208106B2 (en) * 2003-10-24 2007-04-24 Ferro Corporation Method of forming particles
US7338171B2 (en) * 2003-10-27 2008-03-04 Jen-Chuen Hsieh Method and apparatus for visual drive control
EP1708738B1 (de) * 2004-01-12 2016-05-04 MannKind Corporation Verfahren zur verringerung des proinsulinspiegels im serum bei zuckerkranken mit type 2 diabetes
JP2007520555A (ja) * 2004-02-05 2007-07-26 バクスター・インターナショナル・インコーポレイテッド 自己安定化剤の使用により調製された分散剤
PT2319500E (pt) * 2004-03-12 2013-01-23 Biodel Inc Composições de distribuição de fármacos de actuação rápida
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
AU2005244851B2 (en) * 2004-05-12 2010-08-26 Baxter Healthcare S.A. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
ES2313350T3 (es) * 2004-05-12 2009-03-01 Baxter International Inc. Microesferas de acido nucleico, produccion y suministro de las mismas.
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
CA2566075A1 (en) 2004-05-12 2005-12-01 Baxter Healthcare S.A. Microspheres comprising protein and showing injectability at high concentrations of said agent
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
HUE026797T2 (en) 2004-08-23 2016-07-28 Mannkind Corp Diceto-piperazine salts for drug delivery
CA2604225A1 (en) * 2005-04-27 2006-11-02 Baxter International Inc. Surface-modified microparticles and methods of forming and using the same
ATE362803T1 (de) * 2005-06-11 2007-06-15 Tutech Innovation Gmbh Verfahren zur mikroverkapselung von organischen stoffen in partikelform mittels einsprühen eines inerten überkritischen trägergases zusammen mit beschichtungsmaterial für die organischen stoffe in eine hochdruckwirbelschicht in einem autoklaven
MX2007015183A (es) * 2005-06-14 2008-02-19 Baxter Int Formulaciones farmaceuticas para minimizar las interacciones farmaco-farmaco.
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
KR20120060245A (ko) 2005-09-14 2012-06-11 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
CA2628630A1 (en) * 2005-11-15 2007-05-24 Baxter International Inc. Compositions of lipoxygenase inhibitors
RU2464973C2 (ru) 2006-01-24 2012-10-27 НексБио, Инк. Технология изготовления макромолекулярных микросфер
EP2497484A3 (de) 2006-02-22 2012-11-07 MannKind Corporation Verfahren zur Verbesserung der pharmazeutischen Eigenschaften von Mikropartikeln mit Diketopiperazin und einem Wirkstoff
US7718609B2 (en) * 2006-04-12 2010-05-18 Biodel Inc. Rapid acting and long acting insulin combination formulations
DE102006020148A1 (de) * 2006-05-02 2007-11-08 Universität Bremen Gentechnisch hergestelltes Perlucin und seine Verwendung zur Herstellung von Biomaterialien
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
AU2007281737B2 (en) * 2006-08-04 2013-09-19 Baxter Healthcare S.A. Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
MX2009003661A (es) * 2006-10-06 2009-04-22 Baxter Int Microcapsulas que contienen microparticulas modificadas en la superficie y metodos para formar y utilizar las mismas.
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
EP2425819A1 (de) 2007-02-11 2012-03-07 MAP Pharmaceuticals Inc Verfahren zur therapeutischen Verabreichung von DHE zur schnellen Linderung von Migräne bei gleichzeitiger Minimierung von Nebenwirkungsprofilen
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
MX2010007342A (es) * 2008-01-04 2010-08-26 Biodel Inc Formulaciones de insulina para la liberacion de insulina como una funcion de los niveles de glucosa en el tejido.
EP3281663B8 (de) 2008-06-13 2022-09-21 MannKind Corporation Atemluftbetriebener trockenpulverinhalator zur verabreichung von medikamenten
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
WO2010065387A1 (en) * 2008-12-01 2010-06-10 Innovative Technologies, Inc. Improved preparation of organic compounds for enhanced reactivity
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
US9138705B2 (en) 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
KR20140095483A (ko) 2011-10-24 2014-08-01 맨카인드 코포레이션 통증을 치료하기 위한 방법 및 조성물
HUE051644T2 (hu) 2011-11-18 2021-03-01 Regeneron Pharma Biológiailag lebomló bevonattal ellátott, terápiás fehérjét tartalmazó mikrorészecske orvosi alkalmazásra
JP2015527310A (ja) 2012-06-28 2015-09-17 アンサン バイオファーマ, インコーポレイテッドAnsun Biopharma, Inc. 下気道および中枢気道への送達用微粒子製剤ならびに製造方法
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
KR102499439B1 (ko) 2013-03-15 2023-02-13 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
WO2015010092A1 (en) 2013-07-18 2015-01-22 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
GB201409451D0 (en) 2014-05-28 2014-07-09 Ipabc Ltd Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN108310797A (zh) * 2018-04-09 2018-07-24 南通市华安超临界萃取有限公司 一种超临界流体重结晶装置
AU2020394428A1 (en) 2019-11-25 2022-07-14 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous emulsions
AU2021385363A1 (en) 2020-11-25 2023-06-08 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous membrane emulsification
IL303675A (en) 2020-12-17 2023-08-01 Regeneron Pharma Production of protein thermal microgels

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2837115A1 (de) * 1978-08-25 1980-03-06 Bayer Ag Neues verfahren zur herstellung von sterilen feststoffen
HU196714B (en) * 1984-10-04 1989-01-30 Monsanto Co Process for producing non-aqueous composition comprising somatotropin
US5169968A (en) * 1985-09-10 1992-12-08 Vitamins, Inc. Mass separation of liquid or soluble components from solid materials utilizing supercritical fluids
US4985270A (en) * 1988-01-26 1991-01-15 The Nutrasweet Company Cream substitute ingredient and food products
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
GB8802223D0 (en) * 1988-02-02 1988-03-02 St Ivel Ltd Low fat spread
HU209603B (en) * 1988-10-05 1994-09-28 Upjohn Co Process for production of solid powders in finalydivided microcristallin form
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5301664A (en) * 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5814678A (en) * 1996-02-02 1998-09-29 University Technology Corp. Chemical reactions in water-in-carbon dioxide microemulsions and control thereof

Also Published As

Publication number Publication date
CA2083027C (en) 2004-01-20
AU668367B2 (en) 1996-05-02
EP0542314B9 (de) 2005-05-04
ATE167870T1 (de) 1998-07-15
DE69226064T2 (de) 1998-10-29
EP0542314A1 (de) 1993-05-19
DK0542314T4 (da) 2005-05-17
AU2831092A (en) 1993-05-20
EP0542314B2 (de) 2005-01-05
JPH05293361A (ja) 1993-11-09
DE69226064T3 (de) 2005-07-07
DK0542314T3 (da) 1999-04-12
CA2083027A1 (en) 1993-05-15
US6063910A (en) 2000-05-16
EP0542314B1 (de) 1998-07-01
ES2118778T5 (es) 2005-07-16
ES2118778T3 (es) 1998-10-01
JP3342899B2 (ja) 2002-11-11

Similar Documents

Publication Publication Date Title
DE69226064D1 (de) Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel
ATE159297T1 (de) Expression von menschlichen serumalbumin in methylotrophischen hefen
DE68916048T2 (de) Verfahren zur Herstellung von monodispersen Polymerteilchen mit erhöhter Teilchengrösse.
DE69021607T2 (de) Verfahren zum Herstellen von biaxial orientierten Nylon-Folien.
DE69316405T2 (de) Verfahren zur fermentativen Herstellung von Aminosäuren
DE68913922D1 (de) Verfahren zur Herstellung von niedrigen aliphatischen Kohlenwasserstoffen.
DE68919246D1 (de) Verfahren zur Herstellung von Aminosäuren.
DE3854528D1 (de) Verfahren zur herstellung von biaxial orientierten polymererzeugnissen und so hergestelltes erzeugnis.
DE68919156T2 (de) Verfahren zur Herstellung grosser symmetrischer Polymerteilchen.
DE3779268D1 (de) Glasgegenstand, hergestellt aus einem mit hilfe von gas geformten gel, und verfahren zum herstellen dieses gegenstandes.
DE68923835T2 (de) Verfahren zum Trennen und Rückgewinnung von Proteinen, die in Flüssigkeiten anwesend sind, durch eine Drehsäule.
DE68924579D1 (de) Verfahren zur Herstellung von Polymer-Partikeln und Toner-Partikeln.
DE69027238D1 (de) Verfahren zur kontinuierlichen Herstellung von Kunststoff-Folien und Vorrichtung dafür.
DE69025100T2 (de) Verfahren zur Herstellung von Polycarbonaten mit kontrolliertem Molekulargewicht aus Bischloroformiaten
DE68907735D1 (de) Genfragmente, die die variable region eines anti-hiv-antikoerpers codieren, von diesen exprimierte chimaere anti-hiv-antikoerper und verfahren zu deren herstellung.
AT360184B (de) Verfahren zur herstellung von neuen pentapep- tiden, deren c-terminalen estern und amiden sowie von deren salzen
DE58907247D1 (de) Verfahren zur herstellung von dipeptiden mit c-terminalen nicht-proteinogenen aminosäuren.
DE69015404T2 (de) Verfahren zum Herstellen von oligomeren Bischlorformiatcarbonaten bei niedrigem Phosgenverbrauch.
DE58908855D1 (de) Verfahren zur Herstellung von Gate-Elektroden.
DE3784308T2 (de) Verwendung von somatostatin zur herstellung eines arzneimittels fuer die behandlung von rheumatoider arthritis.
DE413248T1 (de) Substanzen mit heparinaehnlicher struktur und verfahren zur herstellung.
DE68917762T2 (de) Herstellung von alpha-1-Aspartyl-1-phenylalanin-methylester mit geschütztem Stickstoffatom.
DE58907096D1 (de) Verfahren zur Herstellung von Formkörpern und die nach diesem Verfahren erhältlichen Formkörper.
DE3889121T2 (de) Verfahren zur wiederverwertung von organischen flüssigkeiten und verfahren zur herstellung von artikeln durch elektrophoretische abscheidung.
ATE92102T1 (de) Genfragmente, die die variable region eines anti- hiv-antikoerpers codieren, von diesen exprimierte chimaere anti-hiv-antikoerper und verfahren zu deren herstellung.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8339 Ceased/non-payment of the annual fee