DE69226064T2 - Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel - Google Patents

Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel

Info

Publication number
DE69226064T2
DE69226064T2 DE69226064T DE69226064T DE69226064T2 DE 69226064 T2 DE69226064 T2 DE 69226064T2 DE 69226064 T DE69226064 T DE 69226064T DE 69226064 T DE69226064 T DE 69226064T DE 69226064 T2 DE69226064 T2 DE 69226064T2
Authority
DE
Germany
Prior art keywords
solvent
precipitation
production
protein microparticles
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226064T
Other languages
English (en)
Other versions
DE69226064T3 (de
DE69226064D1 (de
Inventor
Pablo G Debenedetti
Gio-Bin Lim
Homme Robert K Prud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25156397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69226064(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Princeton University filed Critical Princeton University
Publication of DE69226064D1 publication Critical patent/DE69226064D1/de
Application granted granted Critical
Publication of DE69226064T2 publication Critical patent/DE69226064T2/de
Publication of DE69226064T3 publication Critical patent/DE69226064T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/98—Preparation of granular or free-flowing enzyme compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/141—Feedstock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
DE69226064T 1991-11-14 1992-11-13 Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel Expired - Fee Related DE69226064T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/792,292 US6063910A (en) 1991-11-14 1991-11-14 Preparation of protein microparticles by supercritical fluid precipitation
US792292 2004-03-03

Publications (3)

Publication Number Publication Date
DE69226064D1 DE69226064D1 (de) 1998-08-06
DE69226064T2 true DE69226064T2 (de) 1998-10-29
DE69226064T3 DE69226064T3 (de) 2005-07-07

Family

ID=25156397

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226064T Expired - Fee Related DE69226064T3 (de) 1991-11-14 1992-11-13 Herstellung von Eiweissmikropartikeln durch Niederschlag ein einem Anti-Lösungsmittel

Country Status (9)

Country Link
US (1) US6063910A (de)
EP (1) EP0542314B9 (de)
JP (1) JP3342899B2 (de)
AT (1) ATE167870T1 (de)
AU (1) AU668367B2 (de)
CA (1) CA2083027C (de)
DE (1) DE69226064T3 (de)
DK (1) DK0542314T4 (de)
ES (1) ES2118778T5 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10470459B2 (en) 2014-05-28 2019-11-12 Ipabc Ltd Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms

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EP0542314B1 (de) 1998-07-01
EP0542314B2 (de) 2005-01-05
DE69226064T3 (de) 2005-07-07
AU668367B2 (en) 1996-05-02
DE69226064D1 (de) 1998-08-06
ES2118778T3 (es) 1998-10-01
US6063910A (en) 2000-05-16
AU2831092A (en) 1993-05-20
EP0542314A1 (de) 1993-05-19
DK0542314T4 (da) 2005-05-17
CA2083027C (en) 2004-01-20
ES2118778T5 (es) 2005-07-16
CA2083027A1 (en) 1993-05-15
EP0542314B9 (de) 2005-05-04
ATE167870T1 (de) 1998-07-15
DK0542314T3 (da) 1999-04-12
JP3342899B2 (ja) 2002-11-11

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