DE69517864D1 - Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen - Google Patents

Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen

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Publication number
DE69517864D1
DE69517864D1 DE69517864T DE69517864T DE69517864D1 DE 69517864 D1 DE69517864 D1 DE 69517864D1 DE 69517864 T DE69517864 T DE 69517864T DE 69517864 T DE69517864 T DE 69517864T DE 69517864 D1 DE69517864 D1 DE 69517864D1
Authority
DE
Germany
Prior art keywords
container
cells
scanned images
data
neighborhood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69517864T
Other languages
English (en)
Other versions
DE69517864T2 (de
Inventor
Ning L Sizto
Louis J Dietz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biometric Imaging Inc
Original Assignee
Biometric Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biometric Imaging Inc filed Critical Biometric Imaging Inc
Publication of DE69517864D1 publication Critical patent/DE69517864D1/de
Application granted granted Critical
Publication of DE69517864T2 publication Critical patent/DE69517864T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
DE69517864T 1994-05-02 1995-05-02 Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen Expired - Fee Related DE69517864T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/236,645 US5556764A (en) 1993-02-17 1994-05-02 Method and apparatus for cell counting and cell classification

Publications (2)

Publication Number Publication Date
DE69517864D1 true DE69517864D1 (de) 2000-08-17
DE69517864T2 DE69517864T2 (de) 2001-03-15

Family

ID=22890377

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69517864T Expired - Fee Related DE69517864T2 (de) 1994-05-02 1995-05-02 Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen

Country Status (6)

Country Link
US (2) US5556764A (de)
EP (2) EP0987535A3 (de)
JP (1) JP3591911B2 (de)
AT (1) ATE194710T1 (de)
CA (1) CA2148204A1 (de)
DE (1) DE69517864T2 (de)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
DE69530323T2 (de) * 1994-09-02 2004-02-12 BD Biosciences, Systems and Reagents, Inc., San Jose Verfahren und vorrichtung zur eichung eines optischen abtasters
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
DE19621312A1 (de) 1996-05-28 1997-12-04 Bayer Ag Maskierung der Hintergrundfluoreszenz und Signalverstärkung bei der optischen Analyse biologisch medizinischer Assays
AU5895898A (en) * 1996-12-20 1998-07-17 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
EP1935983B1 (de) * 1997-05-05 2011-06-22 ChemoMetec A/S Verfahren zur Bestimmung von biologischen Teilchen im Blut
AU736321B2 (en) 1997-05-23 2001-07-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US6710871B1 (en) 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US5834203A (en) * 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
US6316215B1 (en) 1999-12-27 2001-11-13 Edwin L. Adair Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
CA2328408C (en) * 1998-05-14 2005-02-15 Luminex Corporation Zero dead time architecture and method for flow cytometer
EP2045334A1 (de) 1998-06-24 2009-04-08 Illumina, Inc. Dekodierung von Arraysensoren mit Mikrosphären
US6873719B1 (en) * 1998-08-19 2005-03-29 Oxoid Limited Image acquisition apparatus
KR20010090718A (ko) 1998-08-21 2001-10-19 써로메드, 인크. 마이크로볼륨 레이저-스캐닝 사이토미터용 신규한 광학구조물
US6423505B1 (en) 1998-12-03 2002-07-23 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
US6200766B1 (en) 1998-12-03 2001-03-13 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells
US6130745A (en) 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
WO2000071991A1 (en) * 1999-05-25 2000-11-30 Biometric Imaging, Inc. Apparatus and method for optical detection in a limited depth of field
JP2003505707A (ja) * 1999-07-21 2003-02-12 サーロメッド・インコーポレーテッド 微小体積レーザ・スキャニング・サイトメトリのためのシステム
US6687395B1 (en) 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US7045049B1 (en) 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US20040178076A1 (en) * 1999-10-01 2004-09-16 Stonas Walter J. Method of manufacture of colloidal rod particles as nanobarcodes
US20040209376A1 (en) * 1999-10-01 2004-10-21 Surromed, Inc. Assemblies of differentiable segmented particles
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6190877B1 (en) 1999-12-27 2001-02-20 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques
US6984498B2 (en) * 1999-12-27 2006-01-10 Adair Edwin L Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6750037B2 (en) 1999-12-27 2004-06-15 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
WO2002025280A1 (en) 2000-09-20 2002-03-28 Surromed, Inc. Method for monitoring resting and activated platelets in unfixed blood samples
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
WO2002044715A1 (en) * 2000-11-28 2002-06-06 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
CA2468774C (en) 2000-11-29 2015-06-30 George E. Seidel System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
WO2002080647A2 (en) * 2001-04-03 2002-10-17 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
AU2002335715A1 (en) * 2001-09-07 2003-03-24 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
EP1448992A4 (de) * 2001-11-20 2005-11-02 Burstein Technologies Inc Optische bio-disks und fluidische kreisläufe zur analyse von zellen und damit verbundene verfahren
CA2474509C (en) * 2002-02-14 2012-01-31 Immunivest Corporation Methods and algorithms for cell enumeration in a low-cost cytometer
US7764821B2 (en) * 2002-02-14 2010-07-27 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
US6846311B2 (en) * 2002-04-02 2005-01-25 Acueity, Inc. Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence
CA2484625A1 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
WO2003102224A1 (fr) * 2002-05-30 2003-12-11 Fuji Electric Holdings Co., Ltd. Procede de comptage de micro-organismes ou de cellules
DE60307545T2 (de) * 2002-06-21 2007-10-04 Adair, Edwin L., Castle Pines Village Anwendung von Metalloporphyrinen zur Behandlung von Arteriosklerose
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
EP2275533B9 (de) 2002-08-01 2016-10-19 Xy, Llc Verfahren zur Schätzung von Spermzellen
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7326573B2 (en) * 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
DK2959774T3 (da) 2003-03-28 2019-05-13 Inguran Llc Fremgangsmåde til kryokonservering af sædceller
WO2004104178A2 (en) 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
US20050019556A1 (en) * 2003-06-17 2005-01-27 Surromed, Inc. Labeling and authentication of metal objects
DE10327839A1 (de) * 2003-06-20 2005-01-05 Arvinmeritor Gmbh Fahrzeugdachmodul
WO2005020890A2 (en) * 2003-07-11 2005-03-10 Surromed, Inc. Multiplexed molecular beacon assay for detection of pathogens
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
CA2956645A1 (en) * 2003-07-12 2005-03-31 David A. Goldberg Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
BRPI0509485A (pt) 2004-03-29 2007-09-11 Monsanto Technology Llc suspensões de esperma para uso em inseminação
JP4598426B2 (ja) * 2004-03-30 2010-12-15 富士通株式会社 境界抽出方法、プログラムおよびこれを用いた装置
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP2006003653A (ja) * 2004-06-17 2006-01-05 Olympus Corp 生体試料観察システム
EP1761816B1 (de) * 2004-06-17 2010-09-01 Koninklijke Philips Electronics N.V. Autofocus-mechanismus für ein spektroskopisches system
EP1769067A2 (de) 2004-07-22 2007-04-04 Monsanto Technology LLC Verfahren zur anreicherung einer population von samenzellen
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
CA2588126C (en) * 2004-11-24 2014-01-07 Battelle Memorial Institute Optical system for cell imaging
WO2006086382A2 (en) * 2005-02-08 2006-08-17 Northrop Grumman Corporation System and methods for use in detecting harmful aerosol particles
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7804594B2 (en) * 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
CA2683134A1 (en) * 2007-05-07 2008-11-13 Ge Healthcare Bio-Sciences Corp. System and method for the automated analysis of cellular assays and tissues
US8159670B2 (en) * 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
NL1038359C2 (en) 2010-03-31 2012-06-27 Aquamarijn Res B V Device and method for separation of circulating tumor cells.
WO2012009617A2 (en) 2010-07-16 2012-01-19 Luminex Corporation Methods, storage mediums, and systems for analyzing particle quantity and distribution within an imaging region of an assay analysis system and for evaluating the performance of a focusing routing performed on an assay analysis system
EP2616990A1 (de) * 2010-09-16 2013-07-24 University Of Kansas System und verfahren zur digitalen bewertung von zellblockierungspräparaten
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
CA2815951A1 (en) 2010-11-03 2012-05-10 Reametrix Inc. Measurement system for fluorescent detection, and method therefor
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2767133T3 (es) 2011-06-24 2020-06-16 Becton Dickinson Co Citometría de flujo de exploración de espectro de absorción
EP3441142A1 (de) 2011-11-16 2019-02-13 Becton, Dickinson and Company Verfahren und systeme zum nachweis eines analyts in einer probe
EP2911791A4 (de) 2012-10-29 2016-11-02 Mbio Diagnostics Inc Biopartikelidentifikationssystem, kartusche und zugehörige verfahren
CN104755925B (zh) 2013-01-11 2017-06-23 贝克顿·迪金森公司 低成本的定点照护测定装置
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US9595092B2 (en) * 2013-05-10 2017-03-14 The Boeing Company Methods and systems for inspection of composite irregularities
US10088407B2 (en) 2013-05-17 2018-10-02 Becton, Dickinson And Company Systems and methods for efficient contours and gating in flow cytometry
US9545471B2 (en) 2013-08-06 2017-01-17 Viatar LLC Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof
KR101463005B1 (ko) 2013-10-15 2014-11-18 (주)한국해양기상기술 특정 파장에 대한 형광 특성을 갖는 미생물 검사방법
US9797899B2 (en) 2013-11-06 2017-10-24 Becton, Dickinson And Company Microfluidic devices, and methods of making and using the same
BR112016010721B1 (pt) 2013-11-13 2021-06-01 Becton, Dickinson And Company Método e sistema de análise de uma amostra para um analito
US9945848B2 (en) 2014-04-14 2018-04-17 Becton, Dickinson And Company Reagent calibration system and method
BR122020024283B1 (pt) 2014-10-14 2023-02-23 Becton, Dickinson And Company Dispositivo de transferência de sangue adaptado para receber uma amostra de sangue
BR112016019471B1 (pt) 2014-10-14 2022-11-22 Becton, Dickinson And Company Dispositivo de mistura e transferência de espécime adaptado para receber uma amostra
US10616219B2 (en) 2014-12-11 2020-04-07 FlowJo, LLC Single cell data management and analysis systems and methods
ES2688270T3 (es) 2015-03-10 2018-10-31 Becton, Dickinson And Company Dispositivo de gestión de micromuestras de fluidos biológicos
US10277906B2 (en) * 2015-03-23 2019-04-30 Arris Enterprises Llc System and method for selectively compressing images
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
EP3278115A2 (de) 2015-03-30 2018-02-07 Accelerate Diagnostics, Inc. Instrument und system zum schnellen identifizieren von mikroorganismen und testen der antimikrobiellen wirkstoffempfindlichkeit
US10876953B2 (en) 2015-07-15 2020-12-29 Becton, Dickinson And Company System and method for label selection
CN108136395B (zh) 2015-09-01 2022-05-13 贝克顿·迪金森公司 用于分离样本相的深度过滤装置
US9830720B2 (en) 2015-09-02 2017-11-28 Becton, Dickinson And Company Graphics control during flow cytometry event gating
CN115639134A (zh) * 2016-06-10 2023-01-24 加利福尼亚大学董事会 基于图像的细胞分选系统和方法
EP3631417B1 (de) 2017-05-25 2024-02-14 Flowjo, LLC Visualisierung, vergleichende analyse, und automatisierte unterschiederkennung für grosse multiparameter-datensätze
US11029242B2 (en) 2017-06-12 2021-06-08 Becton, Dickinson And Company Index sorting systems and methods
WO2019018129A1 (en) 2017-07-18 2019-01-24 Becton, Dickinson And Company DYNAMIC INTERACTIVE DISPLAY OF QUANTITATIVE BIOLOGICAL DATA WITH MULTIPLE PARAMETERS
US10593082B2 (en) 2017-07-18 2020-03-17 Becton, Dickinson And Company Dynamic display of multi-parameter quantitative biological data
CN110770571B (zh) 2017-07-18 2022-09-20 贝克顿·迪金森公司 多参数定量生物学数据的动态交互显示
US10883912B2 (en) 2018-06-04 2021-01-05 Becton, Dickinson And Company Biexponential transformation for graphics display
EP3908824A4 (de) 2019-01-11 2022-10-12 Becton, Dickinson and Company Optimierte sortiergitter
WO2020197785A1 (en) * 2019-03-27 2020-10-01 Becton, Dickinson And Company Systems for cell sorting based on frequency-encoded images and methods of use thereof
US11143587B2 (en) 2019-04-02 2021-10-12 Becton, Dickinson And Company Compensation editor
WO2020219347A1 (en) 2019-04-21 2020-10-29 Becton, Dickinson And Company Cytometric bead array analysis
EP4097228A1 (de) 2020-01-29 2022-12-07 Becton, Dickinson and Company Barkodierte wells zur räumlichen abbildung einzelner zellen durch sequenzierung
US20210278333A1 (en) 2020-01-31 2021-09-09 Becton, Dickinson And Company Methods and systems for adjusting a training gate to accommodate flow cytometer data
CN111507956B (zh) * 2020-04-15 2023-04-07 广西科技大学 一种纳米线数量统计方法及系统
CN113029919B (zh) * 2021-03-13 2024-04-02 长春长光辰英生物科学仪器有限公司 一种细胞富集与荧光计数的检测装置以及检测、计数方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060713A (en) * 1971-06-23 1977-11-29 The Perkin-Elmer Corporation Analysis of images
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US3918812A (en) * 1973-05-07 1975-11-11 Us Energy Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
US3900265A (en) * 1974-03-08 1975-08-19 Intec Corp Laser scanner flaw detection system
US4045772A (en) * 1974-04-29 1977-08-30 Geometric Data Corporation Automatic focusing system
US4122518A (en) * 1976-05-17 1978-10-24 The United States Of America As Represented By The Administrator Of The National Aeronautics & Space Administration Automated clinical system for chromosome analysis
JPS594058B2 (ja) * 1976-07-23 1984-01-27 株式会社日立製作所 白血球像処理方法
US4129854A (en) * 1976-10-25 1978-12-12 Hitachi, Ltd. Cell classification method
US4199748A (en) * 1976-11-01 1980-04-22 Rush-Presbyterian-St. Luke's Medical Center Automated method and apparatus for classification of cells with application to the diagnosis of anemia
US4097845A (en) * 1976-11-01 1978-06-27 Rush-Presbyterian-St. Luke's Medical Center Method of and an apparatus for automatic classification of red blood cells
US4191940A (en) * 1978-01-09 1980-03-04 Environmental Research Institute Of Michigan Method and apparatus for analyzing microscopic specimens and the like
US4282412A (en) * 1978-08-21 1981-08-04 Florin Robert E Mercury switch for monitoring position of patient
US4229797A (en) * 1978-09-06 1980-10-21 National Biomedical Research Foundation Method and system for whole picture image processing
DE2903855A1 (de) * 1979-02-01 1980-08-14 Bloss Werner H Prof Dr Ing Verfahren zum automatischen markieren von zellen und bestimmung der merkmale von zellen aus zytologischen abstrichpraeparaten
US4318886A (en) * 1979-11-19 1982-03-09 Nippon Kogaku K.K. Automatic HLA typing apparatus
JPS58154064A (ja) * 1982-03-08 1983-09-13 Mitsubishi Rayon Co Ltd リンパ球ｔ細胞百分率測定方法
US4513438A (en) * 1982-04-15 1985-04-23 Coulter Electronics, Inc. Automated microscopy system and method for locating and re-locating objects in an image
US4647531A (en) * 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
US4665553A (en) * 1984-05-01 1987-05-12 Ortho Diagnostics Systems Inc. Methods and apparatus for analysis of particles and cells
US4700298A (en) * 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4672559A (en) * 1984-12-26 1987-06-09 E. I. Du Pont De Nemours And Company Method for operating a microscopical mapping system
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US5121436A (en) * 1987-08-14 1992-06-09 International Remote Imaging Systems, Inc. Method and apparatus for generating a plurality of parameters of an object in a field of view
US4845552A (en) * 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US5068909A (en) * 1989-05-18 1991-11-26 Applied Imaging Corporation Method and apparatus for generating quantifiable video displays
US5072382A (en) * 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
USD366938S (en) 1994-09-02 1996-02-06 Biometric Imaging, Inc. Cartridge for processing laboratory samples

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US5556764A (en) 1996-09-17
EP0681177A1 (de) 1995-11-08
JP3591911B2 (ja) 2004-11-24
EP0987535A2 (de) 2000-03-22
DE69517864T2 (de) 2001-03-15
EP0987535A3 (de) 2001-03-21
ATE194710T1 (de) 2000-07-15
CA2148204A1 (en) 1995-11-03
JPH0854333A (ja) 1996-02-27
EP0681177B1 (de) 2000-07-12
US5962238A (en) 1999-10-05

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