DE69517864T2 - Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen - Google Patents

Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen

Info

Publication number
DE69517864T2
DE69517864T2 DE69517864T DE69517864T DE69517864T2 DE 69517864 T2 DE69517864 T2 DE 69517864T2 DE 69517864 T DE69517864 T DE 69517864T DE 69517864 T DE69517864 T DE 69517864T DE 69517864 T2 DE69517864 T2 DE 69517864T2
Authority
DE
Germany
Prior art keywords
container
cells
scanned images
data
neighborhood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69517864T
Other languages
English (en)
Other versions
DE69517864D1 (de
Inventor
Ning L Sizto
Louis J Dietz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biometric Imaging Inc
Original Assignee
Biometric Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biometric Imaging Inc filed Critical Biometric Imaging Inc
Publication of DE69517864D1 publication Critical patent/DE69517864D1/de
Application granted granted Critical
Publication of DE69517864T2 publication Critical patent/DE69517864T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Multimedia (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
DE69517864T 1994-05-02 1995-05-02 Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen Expired - Fee Related DE69517864T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/236,645 US5556764A (en) 1993-02-17 1994-05-02 Method and apparatus for cell counting and cell classification

Publications (2)

Publication Number Publication Date
DE69517864D1 DE69517864D1 (de) 2000-08-17
DE69517864T2 true DE69517864T2 (de) 2001-03-15

Family

ID=22890377

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69517864T Expired - Fee Related DE69517864T2 (de) 1994-05-02 1995-05-02 Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen

Country Status (6)

Country Link
US (2) US5556764A (de)
EP (2) EP0681177B1 (de)
JP (1) JP3591911B2 (de)
AT (1) ATE194710T1 (de)
CA (1) CA2148204A1 (de)
DE (1) DE69517864T2 (de)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
CA2198853A1 (en) * 1994-09-02 1996-03-14 Biometric Imaging, Inc. Calibration method and apparatus for optical scanner
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
DE19621312A1 (de) * 1996-05-28 1997-12-04 Bayer Ag Maskierung der Hintergrundfluoreszenz und Signalverstärkung bei der optischen Analyse biologisch medizinischer Assays
EP2264428B1 (de) 1997-01-31 2017-05-03 Xy, Llc Optisches Gerät mit fokussierendem Reflektor zur Konvergenz von Strahlung auf einen Partikelfluss
EP0980516B1 (de) 1997-05-05 2003-04-02 ChemoMetec A/S Bestimmung von partikeln in einer flüssigen probe
EP0985142A4 (de) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US6710871B1 (en) * 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US5834203A (en) * 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
US6316215B1 (en) 1999-12-27 2001-11-13 Edwin L. Adair Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
JP3946444B2 (ja) * 1998-05-14 2007-07-18 ルミネックス コーポレイション フローサイトメータのデッドタイムをゼロにする構成および方法
AU754952B2 (en) 1998-06-24 2002-11-28 Illumina, Inc. Decoding of array sensors with microspheres
US6873719B1 (en) * 1998-08-19 2005-03-29 Oxoid Limited Image acquisition apparatus
AU749690B2 (en) * 1998-08-21 2002-07-04 Surromed, Inc. Novel optical architectures for microvolume laser-scanning cytometers
US6200766B1 (en) 1998-12-03 2001-03-13 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells
US6423505B1 (en) * 1998-12-03 2002-07-23 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
WO2000071991A1 (en) * 1999-05-25 2000-11-30 Biometric Imaging, Inc. Apparatus and method for optical detection in a limited depth of field
CA2379836A1 (en) * 1999-07-21 2001-02-01 Aaron B. Kantor System for microvolume laser scanning cytometry
US6687395B1 (en) 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US20040178076A1 (en) * 1999-10-01 2004-09-16 Stonas Walter J. Method of manufacture of colloidal rod particles as nanobarcodes
US7045049B1 (en) 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US20040209376A1 (en) * 1999-10-01 2004-10-21 Surromed, Inc. Assemblies of differentiable segmented particles
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6190877B1 (en) 1999-12-27 2001-02-20 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques
US6750037B2 (en) * 1999-12-27 2004-06-15 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6984498B2 (en) * 1999-12-27 2006-01-10 Adair Edwin L Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
AU2001292894A1 (en) * 2000-09-20 2002-04-02 Surromed, Inc. Method for monitoring resting and activated platelets in unfixed blood samples
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
AU2002217904A1 (en) * 2000-11-28 2002-06-11 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
AU2002220018A1 (en) 2000-11-29 2002-06-11 Colorado State University System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
AU2002307090A1 (en) * 2001-04-03 2002-10-21 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
US20030113925A1 (en) * 2001-09-07 2003-06-19 Gordon John Francis Nuclear morphology based identification and quantification of white blood cell types using optical bio-disc systems
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
EP1448992A4 (de) * 2001-11-20 2005-11-02 Burstein Technologies Inc Optische bio-disks und fluidische kreisläufe zur analyse von zellen und damit verbundene verfahren
US7764821B2 (en) * 2002-02-14 2010-07-27 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
WO2003069421A2 (en) * 2002-02-14 2003-08-21 Immunivest Corporation Methods and algorithms for cell enumeration in a low-cost cytometer
US6846311B2 (en) * 2002-04-02 2005-01-25 Acueity, Inc. Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence
CA2484625A1 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
AU2003241857A1 (en) * 2002-05-30 2003-12-19 Fuji Electric Holdings Co., Ltd. Method of counting microorganisms or cells
ATE336266T1 (de) * 2002-06-21 2006-09-15 Adair Edwin Lloyd Anwendung von metalloporphyrinen zur behandlung von arteriosklerose
AU2003265362B2 (en) 2002-08-01 2009-11-05 Xy, Llc. Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
BRPI0313476B1 (pt) 2002-08-15 2015-06-23 Xy Llc Citômetro de fluxo de alta resolução
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7326573B2 (en) * 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
DE602004024874D1 (de) 2003-03-28 2010-02-11 Inguran Llc Eschlechts-sortierten tierspermien
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
WO2004113869A2 (en) * 2003-06-17 2004-12-29 Surromed, Inc. Labeling and authentication of metal objects
DE10327839A1 (de) * 2003-06-20 2005-01-05 Arvinmeritor Gmbh Fahrzeugdachmodul
JP2007531496A (ja) * 2003-07-11 2007-11-08 サロメッド，インコーポレイテッド 病原体を検出するためのマルチプレックス分子ビーコンアッセイ
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2532414C (en) 2003-07-12 2017-03-14 Accelr8 Technology Corporation Sensitive and rapid biodetection
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
ES2397678T3 (es) 2004-03-29 2013-03-08 Inguran, Llc Suspensiones de espermatozoides para clasificación en poblaciones enriquecidas portadoras del cromosoma X o Y
JP4598426B2 (ja) * 2004-03-30 2010-12-15 富士通株式会社 境界抽出方法、プログラムおよびこれを用いた装置
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP2006003653A (ja) * 2004-06-17 2006-01-05 Olympus Corp 生体試料観察システム
JP5047788B2 (ja) * 2004-06-17 2012-10-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 分光システムのためのオートフォーカス機構
MX2007000888A (es) 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
EP2264512B1 (de) * 2004-11-24 2014-06-04 Battelle Memorial Institute Verfahren und Vorrichtung zur Detektion von seltenen Zellen
WO2006086382A2 (en) * 2005-02-08 2006-08-17 Northrop Grumman Corporation System and methods for use in detecting harmful aerosol particles
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7804594B2 (en) * 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
CA2683134A1 (en) * 2007-05-07 2008-11-13 Ge Healthcare Bio-Sciences Corp. System and method for the automated analysis of cellular assays and tissues
US8159670B2 (en) 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
NL1038359C2 (en) 2010-03-31 2012-06-27 Aquamarijn Res B V Device and method for separation of circulating tumor cells.
WO2012009617A2 (en) 2010-07-16 2012-01-19 Luminex Corporation Methods, storage mediums, and systems for analyzing particle quantity and distribution within an imaging region of an assay analysis system and for evaluating the performance of a focusing routing performed on an assay analysis system
EP2616990A1 (de) * 2010-09-16 2013-07-24 University Of Kansas System und verfahren zur digitalen bewertung von zellblockierungspräparaten
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
EP2635895A1 (de) 2010-11-03 2013-09-11 Reametrix Inc. Messsystem zur fluoreszenzdetekion und verfahren dafür
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
EP2724146B1 (de) 2011-06-24 2019-10-23 Becton, Dickinson and Company Absorptionsspektrumsabtastende durchflusszytometrie
US9523682B2 (en) 2011-11-16 2016-12-20 Becton, Dickinson And Company Methods and systems for detecting an analyte in a sample
EP2911791A4 (de) 2012-10-29 2016-11-02 Mbio Diagnostics Inc Biopartikelidentifikationssystem, kartusche und zugehörige verfahren
JP6296457B2 (ja) 2013-01-11 2018-03-20 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 低コストの臨床現場即時アッセイデバイス
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US9595092B2 (en) * 2013-05-10 2017-03-14 The Boeing Company Methods and systems for inspection of composite irregularities
US10088407B2 (en) 2013-05-17 2018-10-02 Becton, Dickinson And Company Systems and methods for efficient contours and gating in flow cytometry
US9545471B2 (en) 2013-08-06 2017-01-17 Viatar LLC Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof
KR101463005B1 (ko) * 2013-10-15 2014-11-18 (주)한국해양기상기술 특정 파장에 대한 형광 특성을 갖는 미생물 검사방법
US9797899B2 (en) 2013-11-06 2017-10-24 Becton, Dickinson And Company Microfluidic devices, and methods of making and using the same
EP3074754A4 (de) 2013-11-13 2017-07-26 Becton, Dickinson and Company Mikrobildgeberanalysesystem mit optik und verfahren zur verwendung davon
WO2015160420A1 (en) 2014-04-14 2015-10-22 Becton, Dickinson And Company Reagent calibration system and method
EP3206581B1 (de) 2014-10-14 2018-09-19 Becton, Dickinson and Company Blutprobenverwaltung mittels offenzelligem schaumstoff
MX2016010432A (es) 2014-10-14 2016-10-17 Becton Dickinson Co Tratamiento de muestras de sangre usando espuma de celdas abiertas.
US10616219B2 (en) 2014-12-11 2020-04-07 FlowJo, LLC Single cell data management and analysis systems and methods
JP6426832B2 (ja) 2015-03-10 2018-11-21 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物体液の極微標本管理装置
US10277906B2 (en) * 2015-03-23 2019-04-30 Arris Enterprises Llc System and method for selectively compressing images
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
WO2016161022A2 (en) 2015-03-30 2016-10-06 Accerlate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
WO2017011549A1 (en) 2015-07-15 2017-01-19 Becton, Dickinson And Company System and method for label selection
CA3109854C (en) 2015-09-01 2023-07-25 Becton, Dickinson And Company Depth filtration device for separating specimen phases
US9830720B2 (en) 2015-09-02 2017-11-28 Becton, Dickinson And Company Graphics control during flow cytometry event gating
EP3469338A4 (de) * 2016-06-10 2020-01-15 The Regents of the University of California Systeme und verfahren zur bildbasierten zellensortierung
WO2018217933A1 (en) 2017-05-25 2018-11-29 FlowJo, LLC Visualization, comparative analysis, and automated difference detection for large multi-parameter data sets
US11029242B2 (en) 2017-06-12 2021-06-08 Becton, Dickinson And Company Index sorting systems and methods
US10636182B2 (en) 2017-07-18 2020-04-28 Becton, Dickinson And Company Dynamic interactive display of multi-parameter quantitative biological data
US10593082B2 (en) 2017-07-18 2020-03-17 Becton, Dickinson And Company Dynamic display of multi-parameter quantitative biological data
EP3655753A1 (de) 2017-07-18 2020-05-27 Becton, Dickinson and Company Dynamische interaktive anzeige von quantitativen biologischen daten mit mehreren parametern
US10883912B2 (en) 2018-06-04 2021-01-05 Becton, Dickinson And Company Biexponential transformation for graphics display
WO2020146733A1 (en) 2019-01-11 2020-07-16 Becton, Dickinson And Company Optimized sorting gates
EP3948221A4 (de) 2019-03-27 2022-12-21 Becton, Dickinson and Company Systeme zur zellsortierung auf basis von frequenzcodierten bildern und verfahren zur verwendung davon
US11143587B2 (en) 2019-04-02 2021-10-12 Becton, Dickinson And Company Compensation editor
WO2020219347A1 (en) 2019-04-21 2020-10-29 Becton, Dickinson And Company Cytometric bead array analysis
US20210230583A1 (en) 2020-01-29 2021-07-29 Becton, Dickinson And Company Barcoded wells for spatial mapping of single cells through sequencing
US20210278333A1 (en) 2020-01-31 2021-09-09 Becton, Dickinson And Company Methods and systems for adjusting a training gate to accommodate flow cytometer data
CN111507956B (zh) * 2020-04-15 2023-04-07 广西科技大学 一种纳米线数量统计方法及系统
CN112597852A (zh) * 2020-12-15 2021-04-02 深圳大学 细胞分类方法、装置、电子设备及存储介质
CN113029919B (zh) * 2021-03-13 2024-04-02 长春长光辰英生物科学仪器有限公司 一种细胞富集与荧光计数的检测装置以及检测、计数方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060713A (en) * 1971-06-23 1977-11-29 The Perkin-Elmer Corporation Analysis of images
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US3918812A (en) * 1973-05-07 1975-11-11 Us Energy Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
US3900265A (en) * 1974-03-08 1975-08-19 Intec Corp Laser scanner flaw detection system
US4045772A (en) * 1974-04-29 1977-08-30 Geometric Data Corporation Automatic focusing system
US4122518A (en) * 1976-05-17 1978-10-24 The United States Of America As Represented By The Administrator Of The National Aeronautics & Space Administration Automated clinical system for chromosome analysis
JPS594058B2 (ja) * 1976-07-23 1984-01-27 株式会社日立製作所 白血球像処理方法
US4129854A (en) * 1976-10-25 1978-12-12 Hitachi, Ltd. Cell classification method
US4199748A (en) * 1976-11-01 1980-04-22 Rush-Presbyterian-St. Luke's Medical Center Automated method and apparatus for classification of cells with application to the diagnosis of anemia
US4097845A (en) * 1976-11-01 1978-06-27 Rush-Presbyterian-St. Luke's Medical Center Method of and an apparatus for automatic classification of red blood cells
US4191940A (en) * 1978-01-09 1980-03-04 Environmental Research Institute Of Michigan Method and apparatus for analyzing microscopic specimens and the like
US4282412A (en) * 1978-08-21 1981-08-04 Florin Robert E Mercury switch for monitoring position of patient
US4229797A (en) * 1978-09-06 1980-10-21 National Biomedical Research Foundation Method and system for whole picture image processing
DE2903855A1 (de) * 1979-02-01 1980-08-14 Bloss Werner H Prof Dr Ing Verfahren zum automatischen markieren von zellen und bestimmung der merkmale von zellen aus zytologischen abstrichpraeparaten
US4318886A (en) * 1979-11-19 1982-03-09 Nippon Kogaku K.K. Automatic HLA typing apparatus
JPS58154064A (ja) * 1982-03-08 1983-09-13 Mitsubishi Rayon Co Ltd リンパ球ｔ細胞百分率測定方法
US4513438A (en) * 1982-04-15 1985-04-23 Coulter Electronics, Inc. Automated microscopy system and method for locating and re-locating objects in an image
US4647531A (en) * 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
US4665553A (en) * 1984-05-01 1987-05-12 Ortho Diagnostics Systems Inc. Methods and apparatus for analysis of particles and cells
US4700298A (en) * 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4672559A (en) * 1984-12-26 1987-06-09 E. I. Du Pont De Nemours And Company Method for operating a microscopical mapping system
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US5121436A (en) * 1987-08-14 1992-06-09 International Remote Imaging Systems, Inc. Method and apparatus for generating a plurality of parameters of an object in a field of view
US4845552A (en) * 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US5068909A (en) * 1989-05-18 1991-11-26 Applied Imaging Corporation Method and apparatus for generating quantifiable video displays
US5072382A (en) * 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
USD366938S (en) 1994-09-02 1996-02-06 Biometric Imaging, Inc. Cartridge for processing laboratory samples

Also Published As

Publication number Publication date
CA2148204A1 (en) 1995-11-03
EP0681177A1 (de) 1995-11-08
EP0681177B1 (de) 2000-07-12
US5962238A (en) 1999-10-05
JP3591911B2 (ja) 2004-11-24
JPH0854333A (ja) 1996-02-27
DE69517864D1 (de) 2000-08-17
US5556764A (en) 1996-09-17
EP0987535A2 (de) 2000-03-22
ATE194710T1 (de) 2000-07-15
EP0987535A3 (de) 2001-03-21

Similar Documents

Publication Publication Date Title
DE69517864D1 (de) Verfahren und Vorrichtung zur Zählung und Klassifizierung von Zellen
EP1234280B1 (de) Verfahren zur untersuchung von zellproben durch bildherstellung und analysen
US8698881B2 (en) Apparatus, method and article to perform assays using assay strips
EP0713086B1 (de) Vorrichtung und Verfahren zum Erkennen und Zählen von selten vorkommenden Säugerzellen
EP0245466B1 (de) Analyseverfahren und vorrichtung für biologische specimen
EP0713087B1 (de) Vorrichtung und Verfahren zum schnellen und hochempfindlichen Erkennen und Zählen von Mikroorganismen mittels Fluoreszenz
CN101836114B (zh) 免疫测定分析方法
ATE194431T1 (de) Optisches probe-analysesystem und verfahren
ATE236386T1 (de) Verfahren zur automatischen bildanalyse biologischer proben
CN108627656B (zh) 医疗样本检测系统、方法及装置
ATE236392T1 (de) Verfahren und vorrichtung zur identifizierung und charakterisierung von biomolekuelen
ATE268008T1 (de) Ein system zur zellbasierten reihenuntersuchung
JP2011007800A (ja) 顕微鏡画像の自動解析法
US20040243318A1 (en) Microbe examining device and method
US6535624B1 (en) Gel electrophoresis image combining for improved dynamic range
US8041086B2 (en) Method of detecting specific polymer crystal
CN106324242B (zh) 量子点试纸条的质检系统及质检方法
Günther et al. Facilitated gate setting by sequential dot plot scanning
EP1439384A3 (de) System für Screening biologischer Zellen
US8229196B2 (en) Method of detecting specific polymer crystal
JP2005291795A (ja) 蛍光検出装置および画像処理システム
JP2000157298A (ja) 染色体異常の解析方法および装置
Laws et al. SignalViewer: analyzing microarray images
Manzur et al. Imaging System and Method for Biomedical Analysis
WO2001032914A1 (en) Method of analysing cell samples, by creating and analysing a resultant image

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee