DE69626423D1 - Verfahren und zusammensetzung zur umgestaltung multi-epitopischer antigene um die immunantwort einzuleiten - Google Patents

Verfahren und zusammensetzung zur umgestaltung multi-epitopischer antigene um die immunantwort einzuleiten

Info

Publication number
DE69626423D1
DE69626423D1 DE69626423T DE69626423T DE69626423D1 DE 69626423 D1 DE69626423 D1 DE 69626423D1 DE 69626423 T DE69626423 T DE 69626423T DE 69626423 T DE69626423 T DE 69626423T DE 69626423 D1 DE69626423 D1 DE 69626423D1
Authority
DE
Germany
Prior art keywords
immune response
antigen
composition
introduce
binding agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69626423T
Other languages
English (en)
Other versions
DE69626423T2 (de
Inventor
Ragupathy Madiyalakan
Antoine A Noujaim
Richard P Baum
Birgit Schultes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Altarex Medical Corp
Original Assignee
ALTAREX CORP WALTHAM
Altarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALTAREX CORP WALTHAM, Altarex Inc filed Critical ALTAREX CORP WALTHAM
Application granted granted Critical
Publication of DE69626423D1 publication Critical patent/DE69626423D1/de
Publication of DE69626423T2 publication Critical patent/DE69626423T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
DE69626423T 1996-05-15 1996-05-15 Verfahren und zusammensetzung zum rekonformieren multiepitopischer antigene zum anregen einer immunantwort Expired - Lifetime DE69626423T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1996/000461 WO1997042973A1 (en) 1996-05-15 1996-05-15 Method and composition for reconforming multi-epitopic antigens to initiate an immune response

Publications (2)

Publication Number Publication Date
DE69626423D1 true DE69626423D1 (de) 2003-04-03
DE69626423T2 DE69626423T2 (de) 2004-03-18

Family

ID=46171074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626423T Expired - Lifetime DE69626423T2 (de) 1996-05-15 1996-05-15 Verfahren und zusammensetzung zum rekonformieren multiepitopischer antigene zum anregen einer immunantwort

Country Status (17)

Country Link
US (7) US6241985B1 (de)
EP (2) EP0910407B1 (de)
JP (1) JP3565351B2 (de)
KR (1) KR20020011137A (de)
AT (1) ATE233102T1 (de)
BR (1) BR9612619A (de)
CA (1) CA2253602A1 (de)
DE (1) DE69626423T2 (de)
DK (1) DK0910407T3 (de)
ES (1) ES2193240T3 (de)
HU (1) HUP9903770A3 (de)
IL (1) IL126803A (de)
NO (2) NO321511B1 (de)
NZ (3) NZ332588A (de)
PT (1) PT910407E (de)
SI (1) SI0910407T1 (de)
WO (1) WO1997042973A1 (de)

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US20060159688A1 (en) * 1996-05-15 2006-07-20 Ragupathy Madiyalakan Method for diagnosing efficacy of xenotypic antibody therapy
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IL139832A0 (en) * 1998-06-15 2002-02-10 Altarex Inc Therapeutic compositions that produce an immune response by altering the antigen
ES2239032T3 (es) * 1999-08-18 2005-09-16 Altarex Medical Corp. Anticuerpo terapeutico contra el antigeno muc-1 y metodos para su uso.
US6716966B1 (en) 1999-08-18 2004-04-06 Altarex Corp. Therapeutic binding agents against MUC-1 antigen and methods for their use
DE10296942T5 (de) * 2001-03-21 2004-11-18 Altarex Corp., Edmonton Therapeutische Zusammensetzung, welche die Immunitätsreaktion verändert
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AU2002358246B2 (en) * 2001-10-26 2008-02-28 Oncoquest Pharmaceuticals Inc. Combination therapy for treating disease
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US8025873B2 (en) 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8029803B2 (en) 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US7429382B2 (en) 2002-10-16 2008-09-30 Corixa Corporation Antibodies that bind cell-associated CA 125/O772P and methods of use thereof
EP1578445A4 (de) * 2002-10-17 2007-04-04 Altarex Medical Corp Therapeutisches adjuvans
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
WO2006099175A2 (en) * 2005-03-11 2006-09-21 Euro-Celtique S.A. Compositions comprising an anti-ca125 antibody and a cytotoxic compound and their use for the treatment of cancer
KR20130118998A (ko) * 2005-07-29 2013-10-30 프로비던스 헬스 앤드 서비시즈, 오레곤 수포에 담긴 불완전 리보솜 생성물（ＤＲｉｂｂｌｅ） 및 면역 반응을 자극하기 위해 이를 이용하는 방법
CN101300355A (zh) * 2005-10-13 2008-11-05 威瑞克斯医药公司 包含丙型肝炎病毒多肽和用于引起免疫应答的Fc片段的嵌合抗原
JP2007320969A (ja) * 2007-09-10 2007-12-13 Altarex Medical Corp 免疫応答を惹起するための、多数エピトープ含有抗原の再構成法および組成物

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Also Published As

Publication number Publication date
DK0910407T3 (da) 2003-06-16
WO1997042973A1 (en) 1997-11-20
AU5658096A (en) 1997-12-05
EP0910407B1 (de) 2003-02-26
NO985304D0 (no) 1998-11-13
NO321511B1 (no) 2006-05-15
US20080311127A1 (en) 2008-12-18
US20080131443A1 (en) 2008-06-05
US20080206318A1 (en) 2008-08-28
US20070036798A1 (en) 2007-02-15
AU711270B2 (en) 1999-10-07
CA2253602A1 (en) 1997-11-20
IL126803A (en) 2003-11-23
NO20061203L (no) 1998-11-13
DE69626423T2 (de) 2004-03-18
NZ332588A (en) 2000-11-24
HUP9903770A2 (hu) 2000-03-28
JPH11509558A (ja) 1999-08-24
ES2193240T3 (es) 2003-11-01
NZ516264A (en) 2002-04-26
NO985304L (no) 1998-11-13
SI0910407T1 (en) 2003-10-31
BR9612619A (pt) 1999-07-20
US6086873A (en) 2000-07-11
NZ505174A (en) 2002-03-01
ATE233102T1 (de) 2003-03-15
HUP9903770A3 (en) 2001-07-30
IL126803A0 (en) 1999-08-17
EP0910407A1 (de) 1999-04-28
US6241985B1 (en) 2001-06-05
US20010036457A1 (en) 2001-11-01
EP1297846A1 (de) 2003-04-02
PT910407E (pt) 2003-07-31
JP3565351B2 (ja) 2004-09-15
KR20020011137A (ko) 2002-02-07

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Owner name: ALTAREX MEDICAL CORP., EDMONTON ALBERTA, CA