DE69714035T2 - Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren - Google Patents

Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren

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Publication number
DE69714035T2
DE69714035T2 DE69714035T DE69714035T DE69714035T2 DE 69714035 T2 DE69714035 T2 DE 69714035T2 DE 69714035 T DE69714035 T DE 69714035T DE 69714035 T DE69714035 T DE 69714035T DE 69714035 T2 DE69714035 T2 DE 69714035T2
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Germany
Prior art keywords
factors
nanospheres
mixture
composition
loaded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69714035T
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English (en)
Other versions
DE69714035D1 (de
Inventor
Brent A Atkinson
John Ranieri
Pedro Bittmann
Marsha Lynn Whitney
James John Benedict
Donald Chickering
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sulzer Markets and Technology AG
Original Assignee
Sulzer Innotec AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sulzer Innotec AG filed Critical Sulzer Innotec AG
Application granted granted Critical
Publication of DE69714035D1 publication Critical patent/DE69714035D1/de
Publication of DE69714035T2 publication Critical patent/DE69714035T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30036—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in release or diffusion time
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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DE69714035T 1997-08-14 1997-08-14 Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren Expired - Lifetime DE69714035T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97810567A EP0896825B1 (de) 1997-08-14 1997-08-14 Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren

Publications (2)

Publication Number Publication Date
DE69714035D1 DE69714035D1 (de) 2002-08-22
DE69714035T2 true DE69714035T2 (de) 2003-03-06

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DE69714035T Expired - Lifetime DE69714035T2 (de) 1997-08-14 1997-08-14 Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren

Country Status (8)

Country Link
US (6) US6582471B1 (de)
EP (1) EP0896825B1 (de)
JP (1) JP2001514935A (de)
AT (1) ATE220564T1 (de)
AU (1) AU746151B2 (de)
CA (1) CA2300415C (de)
DE (1) DE69714035T2 (de)
WO (1) WO1999008728A1 (de)

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US8829166B2 (en) 2002-06-26 2014-09-09 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue

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US20070233269A1 (en) * 2001-05-25 2007-10-04 Conformis, Inc. Interpositional Joint Implant
US20090222103A1 (en) * 2001-05-25 2009-09-03 Conformis, Inc. Articular Implants Providing Lower Adjacent Cartilage Wear
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US20110071645A1 (en) * 2009-02-25 2011-03-24 Ray Bojarski Patient-adapted and improved articular implants, designs and related guide tools
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US7618451B2 (en) 2001-05-25 2009-11-17 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty
US8617242B2 (en) 2001-05-25 2013-12-31 Conformis, Inc. Implant device and method for manufacture
US20110071802A1 (en) * 2009-02-25 2011-03-24 Ray Bojarski Patient-adapted and improved articular implants, designs and related guide tools
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
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US6582471B1 (en) 2003-06-24
US20060216325A1 (en) 2006-09-28
JP2001514935A (ja) 2001-09-18
EP0896825B1 (de) 2002-07-17
ATE220564T1 (de) 2002-08-15
CA2300415C (en) 2009-10-27
DE69714035D1 (de) 2002-08-22
US6514514B1 (en) 2003-02-04
US20090297605A1 (en) 2009-12-03
EP0896825A1 (de) 1999-02-17
USRE41286E1 (en) 2010-04-27
CA2300415A1 (en) 1999-02-25

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