DE69831943D1 - Polyketides und deren herstellung und anwendung - Google Patents
Polyketides und deren herstellung und anwendungInfo
- Publication number
- DE69831943D1 DE69831943D1 DE69831943T DE69831943T DE69831943D1 DE 69831943 D1 DE69831943 D1 DE 69831943D1 DE 69831943 T DE69831943 T DE 69831943T DE 69831943 T DE69831943 T DE 69831943T DE 69831943 D1 DE69831943 D1 DE 69831943D1
- Authority
- DE
- Germany
- Prior art keywords
- rapamycin
- gene
- produced
- cluster
- rapl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9710962 | 1997-05-28 | ||
GBGB9710962.3A GB9710962D0 (en) | 1997-05-28 | 1997-05-28 | Polyketides and their synthesis |
PCT/GB1998/001559 WO1998054308A2 (en) | 1997-05-28 | 1998-05-28 | Polyketides and their synthesis and use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69831943D1 true DE69831943D1 (de) | 2006-03-02 |
DE69831943T2 DE69831943T2 (de) | 2006-07-06 |
Family
ID=10813155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69831943T Expired - Lifetime DE69831943T2 (de) | 1997-05-28 | 1998-05-28 | Polyketides und deren herstellung und anwendung |
Country Status (8)
Country | Link |
---|---|
US (3) | US7018808B2 (de) |
EP (1) | EP0983348B1 (de) |
AT (1) | ATE307198T1 (de) |
AU (1) | AU7666198A (de) |
DE (1) | DE69831943T2 (de) |
ES (1) | ES2251084T3 (de) |
GB (1) | GB9710962D0 (de) |
WO (1) | WO1998054308A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
EP1153124A2 (de) | 1999-02-09 | 2001-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Verfahren zur modulierung der effizienz von polyketide syntase modulen |
US7001748B2 (en) | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
ES2283344T3 (es) | 1999-10-29 | 2007-11-01 | Kosan Biosciences, Inc. | Analogos de la rapamicina. |
FR2825717B1 (fr) | 2001-06-08 | 2005-02-18 | Rhodia Chimie Sa | Preparation stereoselective de l-acides amines cycliques |
MXPA05000139A (es) | 2002-07-16 | 2005-04-11 | Biotica Tech Ltd | Produccion de policetidos y otros productos naturales. |
US7585517B2 (en) * | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
WO2005100366A1 (en) | 2004-04-14 | 2005-10-27 | Wyeth | Proline cci-779 (proline-rapamycin 42-ester with 2,2-bis (hydroxymethyl) propionic acid) and two-step enzymatic synthesis of proline cci-779 and cci-779 using microbial lipase |
GB0417852D0 (en) * | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
SI1848431T1 (sl) * | 2005-02-09 | 2016-05-31 | Santen Pharmaceutical Co., Ltd. | Tekoče formulacije za zdravljenje bolezni ali stanj |
US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
JP5528708B2 (ja) | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
US8222271B2 (en) * | 2006-03-23 | 2012-07-17 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2106034A1 (en) * | 1992-09-24 | 1994-03-25 | Ralph J. Russo | 21-norrapamycin |
ZA938349B (en) * | 1992-11-10 | 1994-08-01 | Smithkline Beecham Corp | Rapamycin derivatives. |
-
1997
- 1997-05-28 GB GBGB9710962.3A patent/GB9710962D0/en active Pending
-
1998
- 1998-05-28 ES ES98924463T patent/ES2251084T3/es not_active Expired - Lifetime
- 1998-05-28 AU AU76661/98A patent/AU7666198A/en not_active Abandoned
- 1998-05-28 EP EP98924463A patent/EP0983348B1/de not_active Expired - Lifetime
- 1998-05-28 DE DE69831943T patent/DE69831943T2/de not_active Expired - Lifetime
- 1998-05-28 AT AT98924463T patent/ATE307198T1/de active
- 1998-05-28 WO PCT/GB1998/001559 patent/WO1998054308A2/en active IP Right Grant
-
2002
- 2002-12-02 US US10/307,595 patent/US7018808B2/en not_active Expired - Fee Related
-
2006
- 2006-01-10 US US11/328,642 patent/US7381546B2/en not_active Expired - Fee Related
-
2008
- 2008-05-29 US US12/129,295 patent/US20080287483A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030104585A1 (en) | 2003-06-05 |
ATE307198T1 (de) | 2005-11-15 |
WO1998054308A3 (en) | 1999-04-08 |
ES2251084T3 (es) | 2006-04-16 |
EP0983348B1 (de) | 2005-10-19 |
US7018808B2 (en) | 2006-03-28 |
GB9710962D0 (en) | 1997-07-23 |
US7381546B2 (en) | 2008-06-03 |
AU7666198A (en) | 1998-12-30 |
US20060105436A1 (en) | 2006-05-18 |
WO1998054308A2 (en) | 1998-12-03 |
DE69831943T2 (de) | 2006-07-06 |
US20080287483A1 (en) | 2008-11-20 |
EP0983348A2 (de) | 2000-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |