DE69839155D1 - Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahren - Google Patents

Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahren

Info

Publication number
DE69839155D1
DE69839155D1 DE69839155T DE69839155T DE69839155D1 DE 69839155 D1 DE69839155 D1 DE 69839155D1 DE 69839155 T DE69839155 T DE 69839155T DE 69839155 T DE69839155 T DE 69839155T DE 69839155 D1 DE69839155 D1 DE 69839155D1
Authority
DE
Germany
Prior art keywords
keratin
hydrogel
disulfide linkages
hair
cysteic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839155T
Other languages
English (en)
Other versions
DE69839155T2 (de
Inventor
Cheryl R Blanchard
Scott F Timmons
Robert A Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keraplast Technologies Ltd
Original Assignee
Keraplast Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keraplast Technologies Ltd filed Critical Keraplast Technologies Ltd
Application granted granted Critical
Publication of DE69839155D1 publication Critical patent/DE69839155D1/de
Publication of DE69839155T2 publication Critical patent/DE69839155T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4741—Keratin; Cytokeratin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/842—Skin; hair; nails; sebaceous glands; cerumen
DE69839155T 1997-11-26 1998-11-25 Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahren Expired - Lifetime DE69839155T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US979456 1997-11-26
US08/979,456 US5932552A (en) 1997-11-26 1997-11-26 Keratin-based hydrogel for biomedical applications and method of production
PCT/US1998/025265 WO1999026595A1 (en) 1997-11-26 1998-11-25 Keratin-based hydrogel for biomedical applications and method of production

Publications (2)

Publication Number Publication Date
DE69839155D1 true DE69839155D1 (de) 2008-04-03
DE69839155T2 DE69839155T2 (de) 2009-02-26

Family

ID=25526898

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839155T Expired - Lifetime DE69839155T2 (de) 1997-11-26 1998-11-25 Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahren

Country Status (5)

Country Link
US (3) US5932552A (de)
EP (1) EP1039873B1 (de)
AT (1) ATE386571T1 (de)
DE (1) DE69839155T2 (de)
WO (1) WO1999026595A1 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528483B2 (en) 1995-06-07 2003-03-04 André Beaulieu Method of producing concentrated non-buffered solutions of fibronectin
US6110487A (en) * 1997-11-26 2000-08-29 Keraplast Technologies Ltd. Method of making porous keratin scaffolds and products of same
US5932552A (en) 1997-11-26 1999-08-03 Keraplast Technologies Ltd. Keratin-based hydrogel for biomedical applications and method of production
US6746485B1 (en) 1999-02-18 2004-06-08 St. Francis Medical Technologies, Inc. Hair used as a biologic disk, replacement, and/or structure and method
US6461628B1 (en) 1999-09-13 2002-10-08 Keraplast Technologies, Ltd. Non-woven keratin cell scaffold
US6270793B1 (en) 1999-09-13 2001-08-07 Keraplast Technologies, Ltd. Absorbent keratin wound dressing
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6371984B1 (en) * 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6316598B1 (en) 1999-09-13 2001-11-13 Keraplast Technologies, Ltd. Water absorbent keratin and gel formed therefrom
US6544548B1 (en) * 1999-09-13 2003-04-08 Keraplast Technologies, Ltd. Keratin-based powders and hydrogel for pharmaceutical applications
JP2003522806A (ja) 2000-02-15 2003-07-29 ジェンザイム、コーポレーション 改良された薬物送達のための生体高分子の修飾
US6749865B2 (en) * 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
US6740093B2 (en) 2000-02-28 2004-05-25 Stephen Hochschuler Method and apparatus for treating a vertebral body
US6649740B1 (en) * 2000-03-01 2003-11-18 Keraplast Technologies, Ltd. Hydratable form of keratin for use as a soil amendment
CN100489280C (zh) * 2001-08-06 2009-05-20 西南研究会 测试催化式排气净化器耐用性的方法和装置
JP4302518B2 (ja) 2001-08-31 2009-07-29 ケラテク リミテッド 可溶性ｓ−スルホン化ケラチン誘導体からの生体高分子材料の薄膜、繊維、発泡体又は接着剤の製造
US7001988B2 (en) * 2001-09-25 2006-02-21 Keraplast Technologies, Ltd. Methods for controlling peptide solubility, chemically modified peptides, and stable solvent systems for producing same
US7921999B1 (en) * 2001-12-20 2011-04-12 Watson Laboratories, Inc. Peelable pouch for transdermal patch and method for packaging
US7630403B2 (en) * 2002-03-08 2009-12-08 Texas Instruments Incorporated MAC aggregation frame with MSDU and fragment of MSDU
JP2006508027A (ja) * 2002-04-10 2006-03-09 ケラプラスト テクノロジーズ， リミテッド シリコーン含有結合によって架橋された不均質タンパク質ネットワーク、およびそれらを生成する方法
US20040120910A1 (en) * 2002-04-10 2004-06-24 Dyke Mark Van Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks
US7001987B2 (en) * 2002-04-22 2006-02-21 Keraplast Technologies, Ltd. Hydrogel with controllable mechanical, chemical, and biological properties and method for making same
US6914126B2 (en) * 2002-04-10 2005-07-05 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks
US6989437B2 (en) * 2002-04-10 2006-01-24 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks
US7892185B2 (en) * 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
NZ550755A (en) * 2002-06-10 2009-06-26 Keratec Ltd Orthopaedic materials derived from keratin
JP4638735B2 (ja) 2002-06-24 2011-02-23 タフツ ユニバーシティー 絹糸生体材料およびその使用方法
US20040082717A1 (en) * 2002-06-24 2004-04-29 Southwest Research Institute Keratin-silicone copolymers and interpenetrating networks (IPN's), methods of production and methods of use thereof
US20040062793A1 (en) * 2002-07-05 2004-04-01 Dyke Mark Van Tissue defect dressings comprising proteinaceous networks
US7163321B2 (en) * 2002-07-25 2007-01-16 Steven Contarino Emergency vehicle grille
WO2004016217A2 (en) 2002-08-15 2004-02-26 David Gerber Controlled artificial intervertebral disc implant
DE20321571U1 (de) * 2002-08-15 2008-02-14 Synthes Gmbh Bandscheibenimplantat
EP1572132A4 (de) * 2002-11-28 2008-10-08 Keratec Ltd Keratinhaltige körperpflegeformulationen
JP4698596B2 (ja) 2003-04-10 2011-06-08 タフツ ユニバーシティー 濃縮された水性シルクフィブロイン溶液およびそれらの使用
US7767756B2 (en) * 2003-09-19 2010-08-03 Keraplast Technologies, Ltd. Composite materials containing keratin
CA2576040A1 (en) * 2003-10-21 2005-04-28 Bioartificial Gel Technologies Inc. Hydrogel-containing medical articles and methods of using and making the same
BR0304083A (pt) * 2003-10-31 2005-06-28 Maria De Lourdes M Velly Processo de obtenção e beneficiamento do gel, da lâmina, do pó e das soluções produzidas do material protéico da rã, queratina em filme ou não e colágenos do tipo 2,4 e 6; processo de transformação deste material protéicos em gel, em lâmina, em pó, em soluções; uso do gel, uso do pó, uso da lâmina, uso das soluções, uso das aplicações destes produtos e destes materiais em formulações, uso das transformações destes produtos e destes materiais protéicos da rã
AU2004298392A1 (en) * 2003-12-19 2005-06-30 Keratec Limited Wound care products containing keratin
CN1315916C (zh) * 2004-05-27 2007-05-16 四川省宜宾五粮液集团有限公司 动物毛角蛋白原液的制备方法及其应用
US7439012B2 (en) * 2004-08-17 2008-10-21 Wake Forest University Health Sciences Ambient stored blood plasma expanders containing keratose
EP2258704A1 (de) * 2004-10-19 2010-12-08 ArQule, Inc. Synthese aus Imidazooxazol- und Imidazothiazol-hemmern der P38-map-kinase
US7579317B2 (en) * 2005-03-11 2009-08-25 Keratec, Ltd. Nutraceutical composition comprising soluble keratin or derivative thereof
RU2413538C2 (ru) * 2005-03-21 2011-03-10 Сютакоат Аб Противомикробное средство, содержащее цистеиновое соединение, ковалентно связанное с субстратом, в частности, связыванием при помощи s-s мостика через спейсерную молекулу
NZ563763A (en) 2005-05-06 2011-04-29 Keraplast Tech Ltd Hydratable keratin compositions
US8920827B2 (en) 2005-10-21 2014-12-30 Wake Forest University Health Sciences Keratin bioceramic compositions
WO2007095151A2 (en) 2006-02-10 2007-08-23 Wake Forest University Health Sciences Nerve regeneration employing keratin biomaterials
US8273702B2 (en) * 2006-02-17 2012-09-25 Wake Forest University Health Sciences Wound healing compositions containing keratin biomaterials
JP2009527274A (ja) * 2006-02-17 2009-07-30 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ ケラチン医用生体材料から形成されるコーティングおよび生体用インプラント
US20100028451A1 (en) 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
CA2672069A1 (en) * 2006-12-06 2008-06-12 Keratec, Ltd. Bone void fillers and methods of making the same
CA2672529A1 (en) * 2006-12-11 2008-06-19 Keratec, Ltd. Porous keratin construct and method of making the same
KR100841742B1 (ko) * 2006-12-14 2008-06-27 화인코주식회사 하이드로겔 마스크 팩, 이의 제조 방법 및 이의 제조에이용되는 조성물
WO2008106485A2 (en) 2007-02-27 2008-09-04 Trustees Of Tufts College Tissue-engineered silk organs
US20080317826A1 (en) * 2007-05-24 2008-12-25 Robert James Kelly Porous keratin constructs, wound healing assemblies and methods using the same
US20090047260A1 (en) * 2007-08-17 2009-02-19 Wake Forest University Health Sciences Keratin biomaterials for cell culture and methods of use
US9068162B2 (en) * 2007-08-17 2015-06-30 Wake Forest University Health Sciences Keratin biomaterials for cell culture and methods of use
DE102008053114B4 (de) * 2008-10-26 2011-05-05 Technische Universität Braunschweig Pharmazeutischer Keratinschwamm
US8920392B2 (en) * 2009-05-05 2014-12-30 Watson Laboratories, Inc. Method for treating overactive bladders and a device for storage and administration of topical oxybutynin compositions
WO2010132673A1 (en) 2009-05-13 2010-11-18 Keraplast Technologies, Ltd. Biopolymer materials
CA2786400C (en) * 2010-01-05 2018-11-27 Cell Constructs, Inc. Biomaterials made from human hair
CA2791386C (en) * 2010-03-05 2023-10-31 Wake Forest University Health Sciences Keratin gel composition for controlled delivery of a compound
US8545893B2 (en) * 2010-03-08 2013-10-01 Wake Forest University Health Sciences Keratin biomaterials for treatment of ischemia
WO2012068376A2 (en) 2010-11-17 2012-05-24 Wake Forest University Health Sciences Keratin compositions for treatment of bone deficiency or injury
CN102416196A (zh) * 2011-02-14 2012-04-18 蒙一纯 一种生物医学工程用角蛋白材料的制备方法
US10335519B2 (en) 2011-04-20 2019-07-02 Trustees Of Tufts College Dynamic silk coatings for implantable devices
WO2013025941A1 (en) 2011-08-17 2013-02-21 Keranetics Llc Low protein percentage gelling compositions
EP2744820B1 (de) 2011-08-17 2018-07-25 Keranetics LLC Verfahren zur extraktion von keratinischen proteinen
CA2867464A1 (en) 2012-03-20 2013-09-26 Trustees Of Tufts College Silk reservoirs for drug delivery
CA2869967A1 (en) 2012-04-13 2013-10-17 Trustees Of Tufts College Methods and compositions for preparing a silk microsphere
WO2014012101A1 (en) 2012-07-13 2014-01-16 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
US9827245B2 (en) * 2013-03-15 2017-11-28 KeraNetics, LLC Keratin compositions comprising halofuginone
JP6457482B2 (ja) 2013-03-15 2019-01-23 トラスティーズ オブ タフツ カレッジ 低分子量絹組成物および絹組成物の安定化
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
US10285702B2 (en) 2013-04-24 2019-05-14 Trustees Of Tufts College Bioresorbable biopolymer anastomosis devices
WO2016100721A1 (en) 2014-12-17 2016-06-23 Tufts University Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair
AU2016296984B2 (en) 2015-07-20 2021-08-26 Massachusetts Eye And Ear Infirmary Biodegradable silk ear tubes
US10864299B2 (en) 2016-04-29 2020-12-15 Trustees Of Tufts College Artificial silk based innervated cornea
WO2018006037A1 (en) 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
US11248313B2 (en) 2016-08-01 2022-02-15 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
US10723774B2 (en) * 2016-11-17 2020-07-28 University Of South Carolina Keratin-based hydrogels
US20200000713A1 (en) 2017-01-20 2020-01-02 Massachusetts Institute Of Technology Injectable polymer micro-depots for controlled local drug delivery
US20180303674A1 (en) * 2017-04-24 2018-10-25 Cell Constructs I, Llc Skin-protective hydrogel wound dressing
GB201707143D0 (en) 2017-05-04 2017-06-21 Plasticell Ltd Method for producing cells
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
US20210236644A1 (en) 2017-11-10 2021-08-05 Cocoon Biotech Inc. Ocular applications of silk-based products
CA3142608A1 (en) 2019-06-04 2020-12-10 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
CN111202868B (zh) * 2020-01-17 2022-01-28 重庆大学 用于制备角蛋白凝胶敷料的组合物及其制备方法和应用
CN112263710B (zh) * 2020-09-23 2021-12-07 同济大学 一种兼具抗炎和骨-软骨修复功能的生物陶瓷支架及其制备方法与应用
US11401239B1 (en) 2020-10-13 2022-08-02 Fxi Inc. Limited Process for converting disulfides to conversion products and process for producing cysteic acid
CN114618010A (zh) * 2020-12-09 2022-06-14 四川大学 一种具有多功能的角蛋白基水凝胶及其制备方法

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE531446C (de) 1929-11-08 1931-08-10 Eduard Lingel Schuhfabrik A G Naht fuer Schuhwerk und Verfahren zu ihrer Herstellung
NL51508C (de) * 1938-08-26 1900-01-01
CS148810B1 (de) 1969-06-13 1973-05-24
US4172823A (en) 1970-03-26 1979-10-30 Ceskoslovenska Akademie Ved Method of preparing cross-linked hydrogels
US4123406A (en) 1970-03-26 1978-10-31 Ceskoslovenska Akademie Ved Method of preparing shaped articles from cross-linked hydrogels
SE391122B (sv) 1971-01-25 1977-02-07 Cutter Lab Protes i form av en ryggradsbroskskiva och forfarande for framstellning derav
US4183884A (en) 1973-01-24 1980-01-15 Ceskoslovenska Akademie Ved Method for manufacturing hydrogel tubes
CS164542B1 (de) 1973-02-15 1975-11-07
CS173836B1 (de) 1974-03-19 1977-03-31
CS169274B1 (de) 1974-03-29 1976-07-29
US3875595A (en) 1974-04-15 1975-04-08 Edward C Froning Intervertebral disc prosthesis and instruments for locating same
CS179567B1 (en) 1974-11-25 1977-11-30 Vladimir Stoy Ionogennic hydrophilic in water insoluble gels based on partial saponificated polymers or copolymers acrylonitrile and method of preparing them
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
CA1146301A (en) 1980-06-13 1983-05-17 J. David Kuntz Intervertebral disc prosthesis
US4309777A (en) 1980-11-13 1982-01-12 Patil Arun A Artificial intervertebral disc
US4357274A (en) 1981-08-06 1982-11-02 Intermedicat Gmbh Process for the manufacture of sclero protein transplants with increased biological stability
US4570629A (en) * 1982-03-17 1986-02-18 University Of Illinois Foundation Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same
US4485097A (en) 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
JPS59155248A (ja) 1983-02-22 1984-09-04 テルモ株式会社 被覆膜およびその製法
LU85081A1 (fr) * 1983-11-09 1985-07-17 Oreal Medicament et composition medicamenteuse pour le traitement et/ou la prevention des maladies de la peau mettant en jeu un processus inflammatoire
US4685447A (en) 1985-03-25 1987-08-11 Pmt Corporation Tissue expander system
CH671691A5 (de) 1987-01-08 1989-09-29 Sulzer Ag
US4714469A (en) 1987-02-26 1987-12-22 Pfizer Hospital Products Group, Inc. Spinal implant
GB8718627D0 (en) 1987-08-06 1987-09-09 Showell A W Sugicraft Ltd Spinal implants
US4772287A (en) 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
JPH01136655A (ja) 1987-11-24 1989-05-29 Asahi Optical Co Ltd 人工椎間板
US4874389A (en) 1987-12-07 1989-10-17 Downey Ernest L Replacement disc
US4911718A (en) 1988-06-10 1990-03-27 University Of Medicine & Dentistry Of N.J. Functional and biocompatible intervertebral disc spacer
US5484437A (en) 1988-06-13 1996-01-16 Michelson; Gary K. Apparatus and method of inserting spinal implants
US5047249A (en) * 1988-07-22 1991-09-10 John Morris Co., Inc. Compositions and methods for treating skin conditions and promoting wound healing
US4969888A (en) 1989-02-09 1990-11-13 Arie Scholten Surgical protocol for fixation of osteoporotic bone using inflatable device
US4936848A (en) 1989-09-22 1990-06-26 Bagby George W Implant for vertebrae
US5059193A (en) 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
FR2661414B1 (fr) 1990-04-25 1995-03-24 Michel Jean Pierre Produit a base de keratines modifiees, son procede de preparation et les applications notamment en medecine humaine ou veterinaire.
CN1056986A (zh) 1990-05-28 1991-12-18 郭素华 利用动物毛生产角蛋白及其提纯方法
US5276138A (en) * 1990-09-17 1994-01-04 Kurashiki Boseki Kabushiki Kaisha Process for solubilizing animal hair
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5192326A (en) 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5123926A (en) 1991-02-22 1992-06-23 Madhavan Pisharodi Artificial spinal prosthesis
US5390683A (en) 1991-02-22 1995-02-21 Pisharodi; Madhavan Spinal implantation methods utilizing a middle expandable implant
JP3007903B2 (ja) 1991-03-29 2000-02-14 京セラ株式会社 人工椎間板
US5824331A (en) 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5306309A (en) 1992-05-04 1994-04-26 Calcitek, Inc. Spinal disk implant and implantation kit
DE4222763A1 (de) 1992-07-10 1994-01-13 Draenert Klaus Implantat und Verfahren zu seiner Herstellung
GB9217578D0 (en) 1992-08-19 1992-09-30 Surgicarft Ltd Surgical implants,etc
US5358935A (en) * 1992-11-19 1994-10-25 Robert Allen Smith Nonantigenic keratinous protein material
JPH06178787A (ja) 1992-12-14 1994-06-28 Shima Yumiko 関節付椎体スペーサ、椎間腔計測器および椎体スペーサ模型
US5660857A (en) 1993-03-22 1997-08-26 Johnson & Johnson Medical Inc. Biopolymer composites
US5534028A (en) 1993-04-20 1996-07-09 Howmedica, Inc. Hydrogel intervertebral disc nucleus with diminished lateral bulging
EP0628573A1 (de) * 1993-05-24 1994-12-14 Kao Corporation Verfahren zur Herstellung solubilisierten Proteins
US5480430A (en) 1993-06-04 1996-01-02 Mcghan Medical Corporation Shape-retaining shell for a fluid filled prosthesis
US5522898A (en) 1993-09-16 1996-06-04 Howmedica Inc. Dehydration of hydrogels
BE1007549A3 (nl) 1993-09-21 1995-08-01 Beckers Louis Francois Charles Implantaat.
US5443514A (en) 1993-10-01 1995-08-22 Acromed Corporation Method for using spinal implants
CN1156255C (zh) 1993-10-01 2004-07-07 美商-艾克罗米德公司 脊椎植入物
US5514180A (en) 1994-01-14 1996-05-07 Heggeness; Michael H. Prosthetic intervertebral devices
US5571189A (en) 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
EP0700671B1 (de) 1994-09-08 2001-08-08 Stryker Technologies Corporation Bandscheibenkern aus Hydrogel
DE69532856T2 (de) 1994-10-17 2005-04-21 Raymedica Inc Zwischenwirbel-discuspulposus-prothese
US5824093A (en) 1994-10-17 1998-10-20 Raymedica, Inc. Prosthetic spinal disc nucleus
US5562736A (en) 1994-10-17 1996-10-08 Raymedica, Inc. Method for surgical implantation of a prosthetic spinal disc nucleus
US5674296A (en) 1994-11-14 1997-10-07 Spinal Dynamics Corporation Human spinal disc prosthesis
FR2728159B1 (fr) 1994-12-16 1997-06-27 Tornier Sa Prothese discale elastique
US5766252A (en) 1995-01-24 1998-06-16 Osteonics Corp. Interbody spinal prosthetic implant and method
US5705780A (en) 1995-06-02 1998-01-06 Howmedica Inc. Dehydration of hydrogels
CA2224253A1 (en) * 1995-06-09 1996-12-27 Martin J. Macphee Chitin hydrogels, methods of their production and use
US5792090A (en) * 1995-06-15 1998-08-11 Ladin; Daniel Oxygen generating wound dressing
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5645597A (en) 1995-12-29 1997-07-08 Krapiva; Pavel I. Disc replacement method and apparatus
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5712252A (en) * 1996-03-08 1998-01-27 The University Of Tennessee Research Corporation Method of augmenting soft tissue in mammals
US5702455A (en) 1996-07-03 1997-12-30 Saggar; Rahul Expandable prosthesis for spinal fusion
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US5800549A (en) 1997-04-30 1998-09-01 Howmedica Inc. Method and apparatus for injecting an elastic spinal implant
US6022376A (en) 1997-06-06 2000-02-08 Raymedica, Inc. Percutaneous prosthetic spinal disc nucleus and method of manufacture
US5932552A (en) 1997-11-26 1999-08-03 Keraplast Technologies Ltd. Keratin-based hydrogel for biomedical applications and method of production
US6113639A (en) 1999-03-23 2000-09-05 Raymedica, Inc. Trial implant and trial implant kit for evaluating an intradiscal space

Also Published As

Publication number Publication date
US6379690B2 (en) 2002-04-30
WO1999026595A1 (en) 1999-06-03
US5932552A (en) 1999-08-03
US20010009675A1 (en) 2001-07-26
ATE386571T1 (de) 2008-03-15
DE69839155T2 (de) 2009-02-26
EP1039873A4 (de) 2003-07-30
US6159496A (en) 2000-12-12
EP1039873B1 (de) 2008-02-20
EP1039873A1 (de) 2000-10-04

Similar Documents

Publication Publication Date Title
DE69839155D1 (de) Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahren
DE60015807T2 (de) Lösliches keratinpeptid
DE69839311T2 (de) Verfahren zum vernetzen von filmen, folien und schüttgut
ATE530179T1 (de) Verwendung von kreatin und/oder kreatinderivaten in dermatologischen zubereitungen
ATE214933T1 (de) Dermatologische zusammensetzungen, welche benzylneroxid und ein mittel zur verminderung von hautreizungen enthalten
ATE247493T1 (de) Verwendung von oxydierter zellulose und ihrer komplexen zur behandlung von chronischen wunden
DE69404281D1 (de) Stabile sulfidepräperate, deren anwendung und herstellung
DE69829933D1 (de) Elektrode aus Festpolymerelektrolyt-Katalysator Kompositen, Elektrode für Brennstoffzellen und Verfahren zur Herstellung dieser Elektroden
DE60335997D1 (de) Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus
BR9501319A (pt) Composição tópica cosmetica e/ou dermatológica utilização desta composição e processo de tratamento cosmético
DE69702655D1 (de) Katalysator für die selektive oxidation von schwefelverbindungen zu elementarschwefel, verfahren zur dessen herstellung und verfahren zur selektive oxidation von schwefelverbindungen zu elementarschwefel
GB0015682D0 (en) Sprayable wound care composition
CA2130967A1 (en) Long life deodorant composition
BR9912634B1 (pt) processo para oxidação de amido, amido oxidado, e, uso de um amido oxidado.
DE69601814D1 (de) Verfahren zur hydrometallurgischen und elektrochemischen Behandlung der aktiven Masse verbrauchter Bleibatterien zwecks Herstellung von Elektrolyt-Blei und Elementar-Schwefel
DE69900160T2 (de) Zusammensetzung, die Harnstoff enthält, und ihre Verwendungen in der Kosmetik und/oder Dermatologie
EA200501440A1 (ru) "способ обработки катализаторов гидроочистки ортофталатом и способ сульфидирования с его использованием"
DE4406922C2 (de) Verfahren zur Haarbehandlung
ATE509066T1 (de) Komplex von polyoxamer und chondroitinsulfat und/oder glycoprotein und seine verwendung
US5958393A (en) Permanent-wave treatment method and a permanent-wave treatment auxiliary agent
DE20301401U1 (de) Pflege u. Heilsalbe zur Behandlung trockener, wunder, stark beanspruchter bzw. strahlengeschädigter Haut
JPH0327310A (ja) パーマネントウェーブ用還元液剤
DE20218572U1 (de) Pflege- und Heilsalbe zur Behandlung trockener, stark beanspruchter bzw. wunder Haut
MX9305045A (es) Proceso para remover o eliminar un aceite soluble en acido, de una mezcla que contiene sulfona, tal como se recupera de un catalizador de alquilacion.
AU711091B2 (en) Keratin fibre modifying compositions

Legal Events

Date Code Title Description
8364 No opposition during term of opposition