DE69926407D1 - Behandlung von krebs mit tetraethylthiuramdisulfid - Google Patents
Behandlung von krebs mit tetraethylthiuramdisulfidInfo
- Publication number
- DE69926407D1 DE69926407D1 DE69926407T DE69926407T DE69926407D1 DE 69926407 D1 DE69926407 D1 DE 69926407D1 DE 69926407 T DE69926407 T DE 69926407T DE 69926407 T DE69926407 T DE 69926407T DE 69926407 D1 DE69926407 D1 DE 69926407D1
- Authority
- DE
- Germany
- Prior art keywords
- cancer
- tetraethylthiuramdisulfide
- treatment
- tetraethylthiuram disulfide
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y116/00—Oxidoreductases oxidizing metal ions (1.16)
- C12Y116/03—Oxidoreductases oxidizing metal ions (1.16) with oxygen as acceptor (1.16.3)
- C12Y116/03001—Ferroxidase (1.16.3.1), i.e. ceruloplasmin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/392,122 US6589987B2 (en) | 1998-09-08 | 1999-09-08 | Method of treating cancer using tetraethyl thiuram disulfide |
US392122 | 1999-09-08 | ||
PCT/US1999/027193 WO2001017522A1 (en) | 1999-09-08 | 1999-11-15 | Method of treating cancer using tetraethyl thiuram disulfide |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69926407D1 true DE69926407D1 (de) | 2005-09-01 |
DE69926407T2 DE69926407T2 (de) | 2006-05-24 |
Family
ID=23549328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69926407T Expired - Lifetime DE69926407T2 (de) | 1999-09-08 | 1999-11-15 | Behandlung von krebs mit tetraethylthiuramdisulfid |
Country Status (9)
Country | Link |
---|---|
US (1) | US6589987B2 (de) |
EP (1) | EP1214063B1 (de) |
JP (1) | JP2003514769A (de) |
AT (1) | ATE300291T1 (de) |
AU (1) | AU782029B2 (de) |
CA (1) | CA2384059C (de) |
DE (1) | DE69926407T2 (de) |
ES (1) | ES2244237T3 (de) |
WO (1) | WO2001017522A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7816403B2 (en) * | 1998-09-08 | 2010-10-19 | University Of Utah Research Foundation | Method of inhibiting ATF/CREB and cancer cell growth and pharmaceutical compositions for same |
US6548540B2 (en) * | 1998-09-08 | 2003-04-15 | Charlotte-Mecklenburg Hospital Authority | Method of treating cancer using dithiocarbamate derivatives |
AU2002226650A1 (en) * | 2001-01-18 | 2002-07-30 | Arnold Hoffman | Redox therapy for tumors |
US20030073609A1 (en) * | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
US7638331B2 (en) | 2004-01-02 | 2009-12-29 | The Administration of the Tulane Rducation Fund | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
WO2006104396A1 (en) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Pre-complexed copper antagonist compositions |
WO2008068746A2 (en) * | 2006-12-04 | 2008-06-12 | Yeda Research And Development Co. Ltd. | Disulfiram doses and treatment regimen suitable for treatment of angiogenesis-dependent disorders |
US20120030779A1 (en) | 2007-01-18 | 2012-02-02 | University Of Utah Research Foundtion | Compositions and methods for detecting, treating, or preventing reductive stress |
CN102026625A (zh) * | 2008-03-17 | 2011-04-20 | 犹他州大学研究基金会 | 二硫代氨基甲酸金属螯合物及其制备和应用的方法 |
GB201020860D0 (en) * | 2010-12-09 | 2011-01-26 | Univ Wolverhampton | Disulfiram formulation and uses thereof |
WO2014152207A1 (en) | 2013-03-15 | 2014-09-25 | Mylan Laboratories, Inc. | Hot melt granulation formulations of poorly water-soluble active agents |
US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
WO2017049529A1 (en) | 2015-09-24 | 2017-03-30 | Innolife Co., Ltd. | A pharmaceutical composition comprising a copper chelating tetramine and the use thereof |
EP3311843A1 (de) * | 2016-10-13 | 2018-04-25 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Zusammensetzungen enthaltend dithiocarbamat und cyclodextrin |
WO2018081309A1 (en) | 2016-10-26 | 2018-05-03 | Cantex Pharmaceuticals, Inc. | Disulfiram and metal salt staggered oral dosing regimen and staggered-release oral unit dosage forms |
DK3459526T3 (da) * | 2017-09-26 | 2021-05-25 | Palacky Univ In Olomouc | Biotilgængelige dithiocarbamat-metalkompleks-nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf |
KR20190056758A (ko) | 2017-11-17 | 2019-05-27 | 주식회사 지뉴브 | 종양줄기세포 특성의 암을 치료하기 위한 항암 병용 요법 |
EP3693740A1 (de) * | 2019-02-07 | 2020-08-12 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Verbesserte dithiocarmabatbasierende verbindungen, therapien und diagnostik |
CN111135175B (zh) * | 2020-01-17 | 2022-09-16 | 中国医学科学院放射医学研究所 | Dsf-2在制备抗肿瘤和抗辐射药物中的应用 |
WO2021257880A1 (en) * | 2020-06-18 | 2021-12-23 | Spring Discovery, Inc. | Use of aldh modulators or gasdermin d inhibitors for prevention and treatment of aging and aging-related disorders and for boosting an immune system |
US11351128B1 (en) * | 2021-05-13 | 2022-06-07 | Lance L. Gooberman | Pharmaceutical compositions and methods of administration |
CN114010624B (zh) * | 2021-12-13 | 2023-03-28 | 上海纳米技术及应用国家工程研究中心有限公司 | 双硫仑和甲氨蝶呤在制备抗肝癌药物中的应用 |
WO2024046332A1 (zh) * | 2022-08-29 | 2024-03-07 | 石贵中 | 医药组合物及其用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4148885A (en) | 1973-09-25 | 1979-04-10 | Institut Merieux | Immunostimulant medicine |
US4426372A (en) | 1980-08-08 | 1984-01-17 | Regents Of The University Of Minnesota | Inhibition of undesired effects of platinum(II) compounds |
US4594238A (en) | 1980-08-08 | 1986-06-10 | Regents Of University Of Minnesota | Inhibition of undesired effect of platinum compounds |
US4581224A (en) | 1980-08-08 | 1986-04-08 | Regents Of The University Of Minnesota | Inhibition of undesired effect of platinum compounds |
US4762705A (en) | 1981-11-10 | 1988-08-09 | Adolf W. Schwimmer | Cancer therapy with interferon |
US4645661A (en) | 1984-06-29 | 1987-02-24 | St. Jude Children's Research Hospital | Method for alleviating cisplatin-induced nephrotoxicity and dithiocarbamate compounds for effecting same |
US5187193A (en) | 1988-09-12 | 1993-02-16 | University Of Rochester | Method for stimulating transplanted bone marrow cells |
US5035878A (en) | 1988-09-12 | 1991-07-30 | University Of Rochester | Use of dithiocarbamates to counteract myelosuppression |
JPH04202139A (ja) | 1990-11-30 | 1992-07-22 | Tosoh Corp | 血管新生抑制剤 |
JP3426599B2 (ja) | 1991-11-08 | 2003-07-14 | ヘモゾル インコーポレイテッド | 薬物担体としてのヘモグロビン |
US5380747A (en) | 1992-10-30 | 1995-01-10 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
US5783596A (en) | 1992-10-30 | 1998-07-21 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
US5807884A (en) | 1992-10-30 | 1998-09-15 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
US5786344A (en) | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
US5792787A (en) | 1995-06-07 | 1998-08-11 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
CA2269838A1 (en) | 1996-11-06 | 1998-05-14 | Morris D. Faiman | Method for treatment of glutamate related disorders |
IL122892A0 (en) | 1998-01-11 | 1998-08-16 | Yeda Res & Dev | Pharmaceutical compositions comprising a thiocarbamate |
IL122891A0 (en) | 1998-01-11 | 1998-08-16 | Yeda Res & Dev | Pharmaceutical compositions comprising a thiocarbamate |
-
1999
- 1999-09-08 US US09/392,122 patent/US6589987B2/en not_active Expired - Lifetime
- 1999-11-15 CA CA2384059A patent/CA2384059C/en not_active Expired - Lifetime
- 1999-11-15 AT AT99963914T patent/ATE300291T1/de not_active IP Right Cessation
- 1999-11-15 EP EP99963914A patent/EP1214063B1/de not_active Expired - Lifetime
- 1999-11-15 AU AU20255/00A patent/AU782029B2/en not_active Expired
- 1999-11-15 WO PCT/US1999/027193 patent/WO2001017522A1/en active IP Right Grant
- 1999-11-15 ES ES99963914T patent/ES2244237T3/es not_active Expired - Lifetime
- 1999-11-15 JP JP2001521313A patent/JP2003514769A/ja active Pending
- 1999-11-15 DE DE69926407T patent/DE69926407T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2001017522A1 (en) | 2001-03-15 |
CA2384059C (en) | 2010-06-22 |
US6589987B2 (en) | 2003-07-08 |
EP1214063A1 (de) | 2002-06-19 |
AU2025500A (en) | 2001-04-10 |
JP2003514769A (ja) | 2003-04-22 |
US20030065026A1 (en) | 2003-04-03 |
DE69926407T2 (de) | 2006-05-24 |
CA2384059A1 (en) | 2001-03-15 |
ES2244237T3 (es) | 2005-12-01 |
ATE300291T1 (de) | 2005-08-15 |
AU782029B2 (en) | 2005-06-30 |
EP1214063B1 (de) | 2005-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69926407D1 (de) | Behandlung von krebs mit tetraethylthiuramdisulfid | |
DE60136730D1 (de) | Methode zur behandlung von krebs mit dithiocarbamat-derivaten | |
DE60223262D1 (de) | Verwendung von fucanen in der behandlung von adhäsion, arthritis und psoriasis | |
MY140767A (en) | Compounds, methods and compositions | |
ATE363850T1 (de) | Elektronenquelle für gerät zum behandeln von lebensmitteln und verfahren | |
MXPA05009694A (es) | Metodos para mejorar la calidad de la piel. | |
HRP20050436A2 (en) | Quinolinyl-pyrrolopyrazoles | |
TW200510927A (en) | Stimulus-sensitive composition, compound and pattern formation method using the stimulation-sensitive composition | |
DE60319066D1 (de) | 1,4-disubstituierte benzokondensierte cycloalkyl-harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen | |
ATE411016T1 (de) | Verfahren zur prophylaxis oder behandlung von östrogen-abhängigen krankheiten | |
GEP20084539B (en) | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain | |
NO20050640L (no) | Rutenium anticancer komplekser | |
NZ331327A (en) | Serine protease inhibitors having an acylguanidine side chain | |
DE60322417D1 (en) | 4-oxo-1-(3-substituiertesphenyl)-1,4-dihydro-1,8-naphthyridin-3-carbonsäureamide alsphoshodiesterase-4-inhibitoren | |
WO2003075828A3 (en) | Compounds useful in the treatment of cancer | |
ATE415161T1 (de) | Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen | |
NO952781L (no) | Potensiering av temozolomid i humane tumorceller | |
HK1033910A1 (en) | Use of erythropoietin in the treatment of multiple myeloma | |
IL151692A0 (en) | Polyamine analogues as cytotoxic agents | |
EP1359909A4 (de) | Krebstherapie unter verwendung von triptolid-prodrugs | |
ATE406897T1 (de) | Kombination von et-743 mit 5-fluorouracil pro- drugs zur behandlung von krebs | |
WO2003073857A3 (de) | Biologisch aktive kupferorganische mittel | |
ATE243522T1 (de) | Verwendung von tall-104 zellen in kombination mit adriamyzin oder cisplatin zur behandlung von malignen tumoren | |
ATE206052T1 (de) | Verwendung von sphingosin-1-phosphat, sphingosin- 1-phosphat-derivaten und/oder deren gemische zur behandlung von entzündlichen hautkrankheiten | |
NO20001758L (no) | FremgangsmÕter og blandinger for behandling av leddgikt |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |