EP1918974A3 - Mass spectrometer assembly and method for ambient liquid mass spectrometry - Google Patents

Mass spectrometer assembly and method for ambient liquid mass spectrometry Download PDF

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Publication number
EP1918974A3
EP1918974A3 EP07119671A EP07119671A EP1918974A3 EP 1918974 A3 EP1918974 A3 EP 1918974A3 EP 07119671 A EP07119671 A EP 07119671A EP 07119671 A EP07119671 A EP 07119671A EP 1918974 A3 EP1918974 A3 EP 1918974A3
Authority
EP
European Patent Office
Prior art keywords
liquid drops
nozzle
analytes
electrospray
traveling path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07119671A
Other languages
German (de)
French (fr)
Other versions
EP1918974A2 (en
Inventor
Jentaie Shiea
Cheng-Hui Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Sun Yat Sen University
Original Assignee
National Sun Yat Sen University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CNA200610142595XA external-priority patent/CN101173914A/en
Priority claimed from US11/746,282 external-priority patent/US20080116366A1/en
Application filed by National Sun Yat Sen University filed Critical National Sun Yat Sen University
Publication of EP1918974A2 publication Critical patent/EP1918974A2/en
Publication of EP1918974A3 publication Critical patent/EP1918974A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/14Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463Desorption by laser or particle beam, followed by ionisation as a separate step
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/16Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165Electrospray ionisation

Abstract

A mass spectrometer including an electrospray-assisted laser desorption ionization device, which includes: an electrospray unit including a nozzle; a voltage supplying member disposed to establish between the nozzle and a receiving unit a potential difference such that liquid drops of the electrospray medium formed at the nozzle are laden with charges, and such that the liquid drops are forced to leave the nozzle toward the receiving unit along a traveling path; a laser desorption unit adapted to irradiate a sample such that analytes contained in the sample are desorbed to fly along a flying path which intersects the traveling path so as to enable the analytes to be occluded in the liquid drops, and such that as a result of dwindling in size of the liquid drops when moving along the traveling path, charges of the liquid drops will pass on to the analytes occluded therein to form ionized analytes.
EP07119671A 2006-10-30 2007-10-30 Mass spectrometer assembly and method for ambient liquid mass spectrometry Withdrawn EP1918974A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA200610142595XA CN101173914A (en) 2006-10-30 2006-10-30 Atmospheric pressure liquid phase mass spectrometric analysis method and atmospheric pressure liquid phase mass spectrograph
US11/746,282 US20080116366A1 (en) 2006-11-17 2007-05-09 Laser desorption device, mass spectrometer assembly, and method for ambient liquid mass spectrometry

Publications (2)

Publication Number Publication Date
EP1918974A2 EP1918974A2 (en) 2008-05-07
EP1918974A3 true EP1918974A3 (en) 2010-03-24

Family

ID=39060250

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07119671A Withdrawn EP1918974A3 (en) 2006-10-30 2007-10-30 Mass spectrometer assembly and method for ambient liquid mass spectrometry

Country Status (3)

Country Link
EP (1) EP1918974A3 (en)
JP (2) JP2008147165A (en)
RU (1) RU2007140232A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226837B1 (en) 2006-05-31 2009-12-28 Semmelweis Egyetem Desorption ionization method and device operated by liquid stream
US7772548B2 (en) * 2008-05-12 2010-08-10 Shimadzu Corporation “Droplet pickup ion source” coupled to mobility analyzer apparatus and method
JP5136642B2 (en) * 2008-05-20 2013-02-06 株式会社島津製作所 Sample introduction method in atmospheric pressure ionization mass spectrometer
RU2558884C2 (en) 2009-05-27 2015-08-10 Майкромасс Юк Лимитед System and method for biological tissue identification
TWI510781B (en) * 2010-10-29 2015-12-01 Scinopharm Taiwan Ltd Real-time monitor solid phase peptide synthesis by mass spectrometry
CN104254772B (en) 2011-12-28 2018-11-16 英国质谱有限公司 The system and method that rapid evaporation for liquid phase sample ionizes
IN2014MN01506A (en) 2011-12-28 2015-05-01 Medimass Kft
JP6278223B2 (en) * 2014-10-20 2018-02-14 株式会社島津製作所 Atmospheric pressure ionizer
JP6593689B2 (en) * 2015-08-27 2019-10-23 高知県公立大学法人 Matrix for MALDI mass spectrometry, method for producing the same, and mass spectrometry using the same
JP7045990B2 (en) * 2016-06-24 2022-04-01 株式会社住化分析センター Physical structure evaluation method
KR102062447B1 (en) * 2018-03-13 2020-01-03 가천대학교 산학협력단 Target surfaces for MALDI mass spectrometry using Graphene films and Mass analysis method using the same
US11532472B2 (en) * 2020-07-30 2022-12-20 Ricoh Company, Ltd. Mass spectrometry

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849847B1 (en) * 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
US20050056776A1 (en) * 2000-06-09 2005-03-17 Willoughby Ross C. Laser desorption ion source
US20050199823A1 (en) * 2004-01-20 2005-09-15 Bruker Daltonik Desorption and ionization of analyte molecules at atmospheric pressure
US20070176113A1 (en) * 2006-01-27 2007-08-02 Jentaie Shiea Electrospray-assisted laser desorption ionization device, mass spectrometer, and method for mass spectrometry

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1876444A3 (en) * 1998-09-17 2008-03-12 Advion BioSciences, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
DE10144250A1 (en) * 2001-08-31 2003-04-03 Fraunhofer Ges Forschung Improved mass spectrometric analysis using nanoparticles
GB0128586D0 (en) * 2001-11-29 2002-01-23 Amersham Biosciences Ab Graphite anchor targets
JP2005243466A (en) * 2004-02-26 2005-09-08 Japan Science & Technology Agency Laser ionization device and its utilization
JP4366508B2 (en) * 2004-03-30 2009-11-18 国立大学法人山梨大学 Ionization method and apparatus for mass spectrometry

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849847B1 (en) * 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
US20050056776A1 (en) * 2000-06-09 2005-03-17 Willoughby Ross C. Laser desorption ion source
US20050199823A1 (en) * 2004-01-20 2005-09-15 Bruker Daltonik Desorption and ionization of analyte molecules at atmospheric pressure
US20070176113A1 (en) * 2006-01-27 2007-08-02 Jentaie Shiea Electrospray-assisted laser desorption ionization device, mass spectrometer, and method for mass spectrometry

Also Published As

Publication number Publication date
JP2013257332A (en) 2013-12-26
JP5707630B2 (en) 2015-04-30
RU2007140232A (en) 2009-05-10
EP1918974A2 (en) 2008-05-07
JP2008147165A (en) 2008-06-26

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