US1682344A - lesieur - Google Patents
lesieur Download PDFInfo
- Publication number
- US1682344A US1682344A US1682344DA US1682344A US 1682344 A US1682344 A US 1682344A US 1682344D A US1682344D A US 1682344DA US 1682344 A US1682344 A US 1682344A
- Authority
- US
- United States
- Prior art keywords
- pressure
- gas
- reducer
- needle
- lever
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007789 gas Substances 0.000 description 34
- 239000003638 chemical reducing agent Substances 0.000 description 21
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000010254 subcutaneous injection Methods 0.000 description 5
- 239000007929 subcutaneous injection Substances 0.000 description 5
- 238000010276 construction Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
Definitions
- the principal object of this invention is to provide a new and improved apparatus for the use of physicians and surgeons for subcutaneous injections of oxygen or other gases in measured quantities under compression into the human body.
- a further object is to include in such an apparatus, one or more pressure reducing devices, to reduce the pressure of the gas supplied to the subcutaneous injection needle.
- Fig. 2 is a plan view of the structure shown in Fig. 1.
- Fig. 8 is a horizontal section through the closure for thegas container.
- Figs. 4 and 5 are sections on the lines H and 5-5 ofFig. 2.
- Fig. 6 is a section on the line 66 of F g. 4.
- Fig. 7 is a section on the line7'7 of Fig. 2, and
- Fig. 8 is a section on theline 88 of Fig. 7.
- Fig. 9 is a plan view of the lowpressure gauge with the dial removed therefrom and Fig. 10 is a section on the hne 10-10 of Fig. 9.
- the gas containor or flask A filled with oxygen orother'gas under high pressure, to be administered, s closed by means of a valved fitting B, and is detachably secured to any suitable base a by means of a strap or collar a, provided with a wing or thumb screw a pivotally secured to the strap and adapted to be moved into or out of the forked end a of said strap.
- the fitting B is provided with a valve B operated by the knurled nut B and has a laterally extending branch 13?
- a three way connection C has one of its branches connected to the fitting B by means of a small tube 6; the second branch of said connection leads to a pressure gauge D for registering the pressure in the gas container A; and the third branch OI said connection is connectedwith a first pres- 704,336, and in France August 11, 192B.
- a tube 6 leads the gas from the reducer E to a second pressure reducer F,
- a plus and minus pressure recording gauge K is container A, passes into the chamber 16 defined by the casing of the reducer and a diaphragm 1 9.
- the lever 3 is provided with an adjusting I screw 4 to regulate the pressure of a counterspring 18 which serves to normally urge the pivoted lever B in a clockwise direction about a pivot 3, Fig. 4, and hold the disc 2 seated upon the mouth of the'conduit e.
- the other end of the lever 3 has pivotally' secured thereto the upper'end of a small thrust member 7 the lower pointed end of'which rests upon the widened end of a swinging lever 5.
- the widened end of the lever 5 is supported upon the base of the reducer E by a pair of spaced pins 6 and is normally urged by the pressure of the thrust member 7, about said pins as a fulcrum, in a clockwise direction to cause the other end of the lever 5 to be normally held with a yielding pressure (due to the spring 18) against a diaphragm 9 secured between the casing of the reducer and a cover 11; said diaphragm and cover being held securely in place by a nut 10.
- a spring 1 1 is arranged between the upper face of the diaphragm'Q and the inner face of the cover 11.
- the tension of the spring 14 is calculated so as to secure an automatic operation ofthe reducer and insure a predetermined pressure, for example, one kilogram pcr square centimetre, within the chamber 16.
- the gas passes from the chamber 16 by the small orifice 18 to the tube 6, by which it is conducted to the second reducer F.
- the reducer F (Fig. 5) serves to further reduce the pressure of the gas and is similar in construction and operation to the reducer E, with the exception that the tension of the spring 14 is less than that of the spring 14 and can be adjusted by means of a screw 12.
- the screw 12 is mounted in the top of the cover 11 and presses against the upper end of a button 13 to compress the spring 1.4 confined between said button 13 and a circular plate 15 bearing against the upper face of the diaphragm 9.
- the lower end of a button 17 secured on said diaphragm bears against lever 5.
- the remainder of the re ducer F is similar in construction and operation to the reducer E and the parts thereof bear similar reference characters. It will be seen that the first reducer E produces a given decrease ofthe gas pressure, whereas the second reducer F allows of the gas pressure being further decreased and finely regulated.
- the gas After passing through the second reducer F, the gas passes through the tube G, which is constructed of, flexible material, so that in case of excessive pressure, the tube will burst and thereby act as a safety valve.
- The'tube G conducts the gas to the measuring cocl: H which consists of a valve casing 19, having a tapered valve plug or key 20 rotatably mounted therein; a graduated disc 21 secured to said valve casing; and a handle 22 and needle 23, secured to the stem of the valve plug by a lock nut 24.
- the orifice 29 leads to the connection for the tube 54 to which the subcutaneous injunction needle is attached, and a conduit 32, which leadsfrom said connections. connects with a chamber 30 with which the pressure gauge K is connected by the pipe 33.
- the pressure gauge K is arranged to indicate pressures above or below atmospheric, and is provided with an expanding pressure chamber 34 to which the gas is led by the pipe 33.
- a lever 35 is pivotally supported upon the under side of a plate 36 and rests upon the upper wall of the diaphragm box 34; said lever is provided wth an upwardly extending finger 37 which engages within an elongated slot 38 of a gear secured 39.
- the operation and use of the complete apparatus is as follows: If a subcutaneous in- An adjection of oxygen or other gas-is to be adv ministered, the needle 55 is inserted into the patient, at the desired point, as for any other injection; the needle of the measuring cock H being brought to the zero position before the needle is inserted. The valve B of the clo sure B is opened and the cock H is then opened slowly until the desired flow of gas, as indicated by the scale 21 is obtained.
- the high pressure of the gas Within the container A is automatically reduced to a pressure sufficiently low for safe injections, by the operation of the pressure reducers E and F, and as the quantity of gas flowing through the cock for the difi'erent adjustments of the valve plug in a given time, may be accuratelydetermined, the amount of gas injected is determined by the reading of the needle 23 and the length of time the gas is permitted to flow.
- the readings of pressure gauge H furnishes a means for determining the presence of obstructions to the flow of the gas such as caused by the insertion of the needle into specially resisting tissue (muscle or aponevrose) or by the presence of a foreign substance, such as a fatty particle, clogging the 7 opening of the needle,
- Man apparatus for the injection of gas a container adapted to contain a quantity of g s u de p s r El ped fmi n dl 99 secure by Letters Patent of the United States necting means leading from said container to said needle, said connecting means including a pressure reducer, a measuring cock, and a safety device interposed therebetween, said safety device being adapted to break the connection between said pressure reducer and said measuring cock and thereby stop the flow of gas to the measuring cock when the pressure of gas passing to said measuring cock exceeds a predetermined amount.
- a container adapted to contain a quantity of said gas under pressure, a hypodermic needle, connecting means leading from said container to said needle, said connecting means including a pressure reducer adapted to reduce the pressure of gas flowing to said needle to a predetermined low pressure, and a flexible tube interposed between said pressure reducer and said needle, the walls of said tube being of such strength that they will burst if the pressure of gas in the tube exceeds a predetermined amount.
- a container adapted to contain a quantity of gas under pressure, a hypodermic needle, connecting means leading from said container to said needle, said connecting means including a pressure reducer, a measuring cock, and a safety device interposed therebetween, said safety device being adapted to break the connection between said pressure reducer and MAURICE LESIEUR.
Description
Aug. 28, 1928.- 1,682,344
, M. LESIE UR APPARATUS FOR m: s BcuTANEous INJECTION OF OXYGEN on OTHER GASES Filed April 5, 4 N Sheets-Sheet 1 flrql. v j;
a 3 2 z i B a I --r fl KITS) I u 35%;.
. I, E I
. ;E v mmzss 3 YIIIVENTOR na/mm Aug. 28, 1928. 1,682,344
M. LESIEUR APPARATUS FOR THE SUBCUTANEOUS INJECTION OF OXYGEN OR OTHER GASES Filed April 5, 1924 2 Sheets-Sheet 2 1mm W A TTOHNEYS Patented Aug. 28, 1928.
* UNITED STATES MAURICE LESIEUR,
on runs, FRANCE.
APPARATUS FOR THE SUBCUTANEOUS INJECTION OF OXYGEN OR OTHER GASES.
Application filed April 5, 1924, Serial .No.
' The principal object of this invention is to provide a new and improved apparatus for the use of physicians and surgeons for subcutaneous injections of oxygen or other gases in measured quantities under compression into the human body. I
A further object is to include in such an apparatus, one or more pressure reducing devices, to reduce the pressure of the gas supplied to the subcutaneous injection needle.
These and such further objects, as the provision of a conipa'ct, portable device, the construction of which will insure safety, reliability and precision in operation will be read ly understood by those skilled in the art to wh ch this invention relates, from the following specification of an illustration orexamnle and by refernece to the accompanying drawing forming a part hereof, and in Which Fig. 1 is a side elevation of an exaniple of an apparatus constructed in accordance with the principles of my invention. 7
Fig. 2 is a plan view of the structure shown in Fig. 1. I
Fig. 8 is a horizontal section through the closure for thegas container.
Figs. 4 and 5 are sections on the lines H and 5-5 ofFig. 2.
Fig. 6 is a section on the line 66 of F g. 4.
Fig. 7 is a section on the line7'7 of Fig. 2, and
Fig. 8 is a section on theline 88 of Fig. 7.
Fig. 9 is a plan view of the lowpressure gauge with the dial removed therefrom and Fig. 10 is a section on the hne 10-10 of Fig. 9.
In the example illustrated. the gas containor or flask A, filled with oxygen orother'gas under high pressure, to be administered, s closed by means of a valved fitting B, and is detachably secured to any suitable base a by means of a strap or collar a, provided with a wing or thumb screw a pivotally secured to the strap and adapted to be moved into or out of the forked end a of said strap. The fitting B is provided with a valve B operated by the knurled nut B and has a laterally extending branch 13? A three way connection C has one of its branches connected to the fitting B by means of a small tube 6; the second branch of said connection leads to a pressure gauge D for registering the pressure in the gas container A; and the third branch OI said connection is connectedwith a first pres- 704,336, and in France August 11, 192B.
sure reducer E. A tube 6 leads the gas from the reducer E to a second pressure reducer F,
from which the gas passes through a connect.
ing tube G to a measuring cock H. A plus and minus pressure recording gauge K is container A, passes into the chamber 16 defined by the casing of the reducer and a diaphragm 1 9. :eated within a suitable recess formed in the lower eiid'of an adjusting screw 3, mounted in a pivoted lever 3, is a small disc 2 of any suitable packing material which is adapted to close the mouth of the conduit 0. the lever 3 is provided with an adjusting I screw 4 to regulate the pressure of a counterspring 18 which serves to normally urge the pivoted lever B in a clockwise direction about a pivot 3, Fig. 4, and hold the disc 2 seated upon the mouth of the'conduit e. The other end of the lever 3 has pivotally' secured thereto the upper'end of a small thrust member 7 the lower pointed end of'which rests upon the widened end of a swinging lever 5. The widened end of the lever 5 is supported upon the base of the reducer E by a pair of spaced pins 6 and is normally urged by the pressure of the thrust member 7, about said pins as a fulcrum, in a clockwise direction to cause the other end of the lever 5 to be normally held with a yielding pressure (due to the spring 18) against a diaphragm 9 secured between the casing of the reducer and a cover 11; said diaphragm and cover being held securely in place by a nut 10. i A spring 1 1 is arranged between the upper face of the diaphragm'Q and the inner face of the cover 11. The tension of the spring 14 is calculated so as to secure an automatic operation ofthe reducer and insure a predetermined pressure, for example, one kilogram pcr square centimetre, within the chamber 16. If the pressure within said chamber falls below the desired amount, the diaphragm 9'will move downwardly and the spring 14% will press the dia- One end of 'hra ma 'ainst the lever 5 causin it to move O b b in a counter clockwise direction upon the pins 6 as a fulcrum, and movlng the lever 3 by 'means of the member 7 against the action of the spring 18, in counter clockwise direction, thus causing the packing d1sc'2 to open the conduit e. An excess of pressure within the chamber 16 will produce a reverse movement of the parts.
The gas passes from the chamber 16 by the small orifice 18 to the tube 6, by which it is conducted to the second reducer F. The reducer F (Fig. 5) serves to further reduce the pressure of the gas and is similar in construction and operation to the reducer E, with the exception that the tension of the spring 14 is less than that of the spring 14 and can be adjusted by means of a screw 12. The screw 12 is mounted in the top of the cover 11 and presses against the upper end of a button 13 to compress the spring 1.4 confined between said button 13 and a circular plate 15 bearing against the upper face of the diaphragm 9. The lower end of a button 17 secured on said diaphragm bears against lever 5. The remainder of the re ducer F is similar in construction and operation to the reducer E and the parts thereof bear similar reference characters. It will be seen that the first reducer E produces a given decrease ofthe gas pressure, whereas the second reducer F allows of the gas pressure being further decreased and finely regulated.
After passing through the second reducer F, the gas passes through the tube G, which is constructed of, flexible material, so that in case of excessive pressure, the tube will burst and thereby act as a safety valve. The'tube G conducts the gas to the measuring cocl: H which consists of a valve casing 19, having a tapered valve plug or key 20 rotatably mounted therein; a graduated disc 21 secured to said valve casing; and a handle 22 and needle 23, secured to the stem of the valve plug by a lock nut 24. a The gas, from the tube G passes into a conduit 25, provided in the valve casing 19, and is led therebyto conduit 27 formed in the valve plug, from which conduit it passes to the annular groove 28 formed in the periphery of said plug and in registry with the exit orifice 29 provided in the valve casing. The annular groove 28 which ends at about three quarters of the circumference of the plug 20 from the conduit 27 is of progressively decreasing depth from said conduit, and the remaining ungrooved quarter circumference of said plug form the closure for the valve H. It will be obvious that the quantity of gas allowed to pass through the cock H in a given time, will depend upon the depth. of that portion of the groove 28 which communicates with the exit orifice 29 therefor; the graduations of the scale 21 being arranged to correspond with the extent of the opening of said valve. The orifice 29 leads to the connection for the tube 54 to which the subcutaneous injunction needle is attached, and a conduit 32, which leadsfrom said connections. connects with a chamber 30 with which the pressure gauge K is connected by the pipe 33. The pressure gauge K is arranged to indicate pressures above or below atmospheric, and is provided with an expanding pressure chamber 34 to which the gas is led by the pipe 33. A lever 35 is pivotally supported upon the under side of a plate 36 and rests upon the upper wall of the diaphragm box 34; said lever is provided wth an upwardly extending finger 37 which engages within an elongated slot 38 of a gear secured 39. The teeth of the gear sector 39 mesh with a small pinion 40 secured upon the shaft 41 which projects through the dial 42 and has secured to its outer end the indicating needle 43, justing screw 44 is threaded into a lug 45 proj ecting upwardly from the base of the casing of the gauge and its inner end is adapted to be engaged with the lower inclined face 46 of a lug 47 which projects downwardly fromthe plate 36, to permit said plate to be raised when I the screw 44 is screwed inwardly, and vice versa, so as to enable the lever 35 to be adjusted relatively to the diaphragm box 34.
The operation and use of the complete apparatus is as follows: If a subcutaneous in- An adjection of oxygen or other gas-is to be adv ministered, the needle 55 is inserted into the patient, at the desired point, as for any other injection; the needle of the measuring cock H being brought to the zero position before the needle is inserted. The valve B of the clo sure B is opened and the cock H is then opened slowly until the desired flow of gas, as indicated by the scale 21 is obtained. The high pressure of the gas Within the container A is automatically reduced to a pressure sufficiently low for safe injections, by the operation of the pressure reducers E and F, and as the quantity of gas flowing through the cock for the difi'erent adjustments of the valve plug in a given time, may be accuratelydetermined, the amount of gas injected is determined by the reading of the needle 23 and the length of time the gas is permitted to flow. The readings of pressure gauge H furnishes a means for determining the presence of obstructions to the flow of the gas such as caused by the insertion of the needle into specially resisting tissue (muscle or aponevrose) or by the presence of a foreign substance, such as a fatty particle, clogging the 7 opening of the needle,
I desire that the foregoing description be understood as illustrative only and not limited to the particular example herein disclosed and that changes, variations and modifications may be resorted to without departing from the spirit of my invention.
Having thus described my invention, I declare that what I claim as new and desire to is: V
1. Man apparatus for the injection of gas, a container adapted to contain a quantity of g s u de p s r El ped fmi n dl 99 secure by Letters Patent of the United States necting means leading from said container to said needle, said connecting means including a pressure reducer, a measuring cock, and a safety device interposed therebetween, said safety device being adapted to break the connection between said pressure reducer and said measuring cock and thereby stop the flow of gas to the measuring cock when the pressure of gas passing to said measuring cock exceeds a predetermined amount.
2. In an apparatus for subcutaneous injection of gas, a container adapted to contain a quantity of said gas under pressure, a hypodermic needle, connecting means leading from said container to said needle, said connecting means including a pressure reducer adapted to reduce the pressure of gas flowing to said needle to a predetermined low pressure, and a flexible tube interposed between said pressure reducer and said needle, the walls of said tube being of such strength that they will burst if the pressure of gas in the tube exceeds a predetermined amount.
3. In an apparatus for the injection of gas,
a container adapted to contain a quantity of gas under pressure, a hypodermic needle, connecting means leading from said container to said needle, said connecting means including a pressure reducer, a measuring cock, and a safety device interposed therebetween, said safety device being adapted to break the connection between said pressure reducer and MAURICE LESIEUR.
Publications (1)
Publication Number | Publication Date |
---|---|
US1682344A true US1682344A (en) | 1928-08-28 |
Family
ID=3416054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US1682344D Expired - Lifetime US1682344A (en) | lesieur |
Country Status (1)
Country | Link |
---|---|
US (1) | US1682344A (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4048992A (en) * | 1974-10-26 | 1977-09-20 | Lindemann Hans Joachim | Insufflator |
US5006109A (en) * | 1989-09-12 | 1991-04-09 | Donald D. Douglas | Method and device for controlling pressure, volumetric flow rate and temperature during gas insuffication procedures |
US5234405A (en) * | 1990-10-10 | 1993-08-10 | Klatz Ronald M | Brain resuscitation device and method for performing the same |
US5584804A (en) * | 1990-10-10 | 1996-12-17 | Life Resuscitation Technologies, Inc. | Brain resuscitation and organ preservation device and method for performing the same |
US5827222A (en) * | 1990-10-10 | 1998-10-27 | Life Resuscitation Technologies, Inc. | Method of treating at least one of brain and associated nervous tissue injury |
US6200289B1 (en) | 1998-04-10 | 2001-03-13 | Milestone Scientific, Inc. | Pressure/force computer controlled drug delivery system and the like |
US20020072700A1 (en) * | 2000-06-30 | 2002-06-13 | Mantell Robert R. | Method and apparatus for humidification and warming of air |
US6485450B1 (en) | 1998-03-16 | 2002-11-26 | Life Science Holdings, Inc. | Brain resuscitation apparatus and method |
US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
US20040224298A1 (en) * | 1998-09-29 | 2004-11-11 | John Brassil | Apparatus and method for determining effects of a substance of an organ |
US20040224299A1 (en) * | 2003-04-04 | 2004-11-11 | Organ Recovery Systems | Method and apparatus for transferring heat to or from an organ or tissue container |
US20040221719A1 (en) * | 2003-04-04 | 2004-11-11 | Organ Recovery Systems, Inc. | Device for separating gas from a liquid path |
US20050221269A1 (en) * | 2004-04-05 | 2005-10-06 | Organ Recovery Systems | Apparatus and method for perfusing an organ or tissue for isolating cells from the organ or tissue |
US20060063142A1 (en) * | 1998-09-29 | 2006-03-23 | Organ Recovery Systems, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20060102174A1 (en) * | 1998-04-10 | 2006-05-18 | Mark Hochman | Handpiece for fluid administration apparatus |
US8211052B1 (en) | 2006-07-13 | 2012-07-03 | Lexion Medical Llc | Charged hydrator |
US10575515B2 (en) | 2010-05-04 | 2020-03-03 | The General Hospital Corporation | Methods and compositions for preserving tissues and organs |
US10918102B2 (en) | 2014-03-13 | 2021-02-16 | The General Hospital Corporation | Devices and methods to improve and assess viability of human livers |
US11136553B2 (en) | 2009-07-01 | 2021-10-05 | Massachusetts Institute Of Technology | Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same |
-
0
- US US1682344D patent/US1682344A/en not_active Expired - Lifetime
Cited By (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4048992A (en) * | 1974-10-26 | 1977-09-20 | Lindemann Hans Joachim | Insufflator |
US5006109A (en) * | 1989-09-12 | 1991-04-09 | Donald D. Douglas | Method and device for controlling pressure, volumetric flow rate and temperature during gas insuffication procedures |
US5234405A (en) * | 1990-10-10 | 1993-08-10 | Klatz Ronald M | Brain resuscitation device and method for performing the same |
US5584804A (en) * | 1990-10-10 | 1996-12-17 | Life Resuscitation Technologies, Inc. | Brain resuscitation and organ preservation device and method for performing the same |
US5709654A (en) * | 1990-10-10 | 1998-01-20 | Life Resuscitation Technologies, Inc. | Apparatus for cooling living tissue |
US5752929A (en) * | 1990-10-10 | 1998-05-19 | Life Resuscitation Technologies, Inc. | Method of preserving organs other than the brain |
US5827222A (en) * | 1990-10-10 | 1998-10-27 | Life Resuscitation Technologies, Inc. | Method of treating at least one of brain and associated nervous tissue injury |
US6485450B1 (en) | 1998-03-16 | 2002-11-26 | Life Science Holdings, Inc. | Brain resuscitation apparatus and method |
US20020052574A1 (en) * | 1998-04-10 | 2002-05-02 | Mark Hochman | Pressure/force computer controlled drug delivery system with automated charging |
US6200289B1 (en) | 1998-04-10 | 2001-03-13 | Milestone Scientific, Inc. | Pressure/force computer controlled drug delivery system and the like |
US7625354B2 (en) | 1998-04-10 | 2009-12-01 | Milestone Scientific, Inc. | Handpiece for fluid administration apparatus |
US20030078534A1 (en) * | 1998-04-10 | 2003-04-24 | Mark Hochman | Drug delivery system with profiles |
US20060102174A1 (en) * | 1998-04-10 | 2006-05-18 | Mark Hochman | Handpiece for fluid administration apparatus |
US6786885B2 (en) | 1998-04-10 | 2004-09-07 | Milestone Scientific Inc | Pressure/force computer controlled drug delivery system with exit pressure control |
US6945954B2 (en) | 1998-04-10 | 2005-09-20 | Milestone Scientific, Inc. | Drug delivery system with profiles |
US6887216B2 (en) | 1998-04-10 | 2005-05-03 | Milestone Scientific, Inc. | Pressure/force computer controlled drug delivery system with automated charging |
US8318415B2 (en) | 1998-09-29 | 2012-11-27 | Lifeline Scientific, Inc. | Method of determining transport and/or storage parameters for maintaining viability of an organ |
US8609400B2 (en) | 1998-09-29 | 2013-12-17 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US8268547B2 (en) | 1998-09-29 | 2012-09-18 | Lifeline Scientific, Inc. | Method of transporting and storing a kidney |
US20040224298A1 (en) * | 1998-09-29 | 2004-11-11 | John Brassil | Apparatus and method for determining effects of a substance of an organ |
US20110129908A1 (en) * | 1998-09-29 | 2011-06-02 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20110059429A1 (en) * | 1998-09-29 | 2011-03-10 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US8268612B2 (en) | 1998-09-29 | 2012-09-18 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20060063142A1 (en) * | 1998-09-29 | 2006-03-23 | Organ Recovery Systems, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
US8962303B2 (en) | 1998-09-29 | 2015-02-24 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US8445260B2 (en) | 1998-09-29 | 2013-05-21 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US7749693B2 (en) | 1998-09-29 | 2010-07-06 | Lifeline Scientific, Inc. | Method of determining that an organ is not suitable for transplantation and using it for testing substances |
US20110039253A1 (en) * | 1998-09-29 | 2011-02-17 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US8431385B2 (en) | 1998-09-29 | 2013-04-30 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US8420381B2 (en) | 1998-09-29 | 2013-04-16 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US8349551B2 (en) | 1998-09-29 | 2013-01-08 | Lifeline Scientific, Inc. | Method for controlling perfusion of an organ |
US7824848B2 (en) | 1998-09-29 | 2010-11-02 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20100221696A1 (en) * | 1998-09-29 | 2010-09-02 | Organ Recovery Systems, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20060033223A1 (en) * | 2000-06-30 | 2006-02-16 | Northgate Technologies, Inc. | Method and apparatus for humidification and warming of air |
US7762251B2 (en) | 2000-06-30 | 2010-07-27 | Northgate Technologies, Inc. | Method and apparatus for humidification and warming of air |
US20100163044A1 (en) * | 2000-06-30 | 2010-07-01 | Mantell Robert R | Method and apparatus for humidification and warming of air |
US7647925B2 (en) | 2000-06-30 | 2010-01-19 | Northgate Technologies, Inc. | Method and apparatus for humidification and warming of air |
US6976489B2 (en) | 2000-06-30 | 2005-12-20 | Northgate Technologies, Inc. | Method and apparatus for humidification and warming of air |
US8955511B2 (en) | 2000-06-30 | 2015-02-17 | Northgate Technologies, Inc. | Method and apparatus for humidification and warming of air |
US10052444B2 (en) | 2000-06-30 | 2018-08-21 | Northgate Technologies Inc. | Method and apparatus for humidification and warming of air |
US8091546B2 (en) | 2000-06-30 | 2012-01-10 | Northgate Technologies, Inc. | Method and apparatus for humidification and warming of air |
US20020072700A1 (en) * | 2000-06-30 | 2002-06-13 | Mantell Robert R. | Method and apparatus for humidification and warming of air |
US8323954B2 (en) | 2000-08-25 | 2012-12-04 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20110183310A1 (en) * | 2000-08-25 | 2011-07-28 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20040221719A1 (en) * | 2003-04-04 | 2004-11-11 | Organ Recovery Systems, Inc. | Device for separating gas from a liquid path |
US20040224299A1 (en) * | 2003-04-04 | 2004-11-11 | Organ Recovery Systems | Method and apparatus for transferring heat to or from an organ or tissue container |
US8128740B2 (en) | 2003-04-04 | 2012-03-06 | Organ Recovery Systems, Inc. | Device for separating gas from a liquid path |
US8097449B2 (en) | 2003-04-04 | 2012-01-17 | Organ Recovery Systems | Method and apparatus for transferring heat to or from an organ or tissue container |
US7998725B2 (en) | 2003-04-04 | 2011-08-16 | Organ Recovery Systems | Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container |
US20100151559A1 (en) * | 2003-04-04 | 2010-06-17 | Lifeline Scientific, Inc. | Method and apparatus for transferring heat to or from an organ or tissue container |
US20100112542A1 (en) * | 2003-04-04 | 2010-05-06 | Organ Recovery Systems, Inc. | Method and apparatus for controlling air pressure in an organ or tissue container |
US8389271B2 (en) | 2003-04-04 | 2013-03-05 | Organ Recovery Systems, Inc. | Method and apparatus for controlling air pressure in an organ or tissue container |
US20040235142A1 (en) * | 2003-04-04 | 2004-11-25 | Organ Recovery Systems | Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container |
US7691622B2 (en) | 2003-04-04 | 2010-04-06 | Lifeline Scientific, Inc. | Method and apparatus for transferring heat to or from an organ or tissue container |
US7678563B2 (en) | 2003-04-04 | 2010-03-16 | Organ Recovery Systems, Inc. | Method and apparatus for controlling air pressure in an organ or tissue container |
US20090226878A1 (en) * | 2004-04-05 | 2009-09-10 | Organ Recovery Systems | Apparatus and method for perfusing an organ or tissue for isolating cells from the organ or tissue |
US7504201B2 (en) | 2004-04-05 | 2009-03-17 | Organ Recovery Systems | Method for perfusing an organ and for isolating cells from the organ |
US20050221269A1 (en) * | 2004-04-05 | 2005-10-06 | Organ Recovery Systems | Apparatus and method for perfusing an organ or tissue for isolating cells from the organ or tissue |
US8389280B2 (en) | 2004-04-05 | 2013-03-05 | Organ Recovery Systems | Method for perfusing an organ for isolating cells from the organ |
US9706769B2 (en) | 2004-04-05 | 2017-07-18 | Organ Recovery Systems, Inc | Apparatus and method for maintaining and/or restoring viability of organs |
US8211052B1 (en) | 2006-07-13 | 2012-07-03 | Lexion Medical Llc | Charged hydrator |
US11136553B2 (en) | 2009-07-01 | 2021-10-05 | Massachusetts Institute Of Technology | Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same |
US10575515B2 (en) | 2010-05-04 | 2020-03-03 | The General Hospital Corporation | Methods and compositions for preserving tissues and organs |
US10918102B2 (en) | 2014-03-13 | 2021-02-16 | The General Hospital Corporation | Devices and methods to improve and assess viability of human livers |
US11917992B2 (en) | 2014-03-13 | 2024-03-05 | The General Hospital Corporation | Devices and methods to improve and assess viability of human livers |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US1682344A (en) | lesieur | |
US4207887A (en) | Gas insufflation apparatus | |
CA1308934C (en) | Method and apparatus for measuring the aggregation of blood-platelets andthe coagulation of blood | |
US1848232A (en) | Resuscitation and artificial respiration apparatus | |
US4317375A (en) | Flowmeter with pressure release | |
US3481323A (en) | Gas injection syringe | |
US2441237A (en) | Tubal insufflator | |
US978641A (en) | Gas-generator. | |
US69894A (en) | beaedsleb | |
US961220A (en) | Valve mechanism. | |
US3521634A (en) | Anesthetizing apparatus | |
US2233506A (en) | Treatment of vocal defects and the vocal organs | |
US1043521A (en) | Blood-pressure-determining device. | |
US2709430A (en) | Portable basal metabolism apparatus | |
US185319A (en) | Improvement in apparatus for testing meters | |
US2957334A (en) | Calibrating apparatus for gauges and like instruments | |
JPH0538750Y2 (en) | ||
US1279549A (en) | Anesthetic-administering apparatus. | |
US611496A (en) | Safety valve | |
US2540176A (en) | Pressure gauge | |
US266543A (en) | Dexter m | |
US987260A (en) | Sounding apparatus. | |
SU391541A1 (en) | N YATKR?]! TII with joining jYa applications —Priority —Dating date description 3.1.1974M.C. G 05d 16''04UDC 621. 646.4 (088.8) | |
RU2120228C1 (en) | Arterial pressure gauge | |
US24874A (en) | Water and alarm gage for steam-boilers |