US1967927A - Device for inserting medicaments into the body by iontophoresis - Google Patents
Device for inserting medicaments into the body by iontophoresis Download PDFInfo
- Publication number
- US1967927A US1967927A US561312A US56131231A US1967927A US 1967927 A US1967927 A US 1967927A US 561312 A US561312 A US 561312A US 56131231 A US56131231 A US 56131231A US 1967927 A US1967927 A US 1967927A
- Authority
- US
- United States
- Prior art keywords
- lining
- iontophoresis
- medicaments
- medicament
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Definitions
- My invention relates to a device for inserting medicaments into the human or animal body by means of iontophoresis It is known to insert medicaments into the body by iontophoresis. To this end the medicament is put on the skin in fluid state and covered with an electrode connected to one pole of a direct current source while the other pole of said current source is connected to another electrode being in contact with any other part of the body. Thus the current flowing through the electrode and the medicament inserts the latter through the skin into the body. Instead of putting the medicament directly upon the skin it is also known to impregnate a pad of cotton-wool with the medicament and to lay this pad under the one electrode upon the skin. Both methods have several disadvantages.
- One object of my invention is to provide means for performing the iontophoresis which can be used by everybody without danger of poisoning by the poisonous medicaments necessary therefor.
- Another object is to provide a device for the said purpose by which the waste of medicaments is avoided. Another object is to prevent burning of the skin by the current.
- My invention consists in a lining for the active electrode for the iontophoresis, said lining consisting of a material being impregnated with the necessary quantity of the medicament.
- This impregnated lining which may consist of filteringpaper, blotting-paper, textile fabric or the like can be given into the hand of the patient without scruple as wrong use of it is impossible so that the patient is thus enabled to cure his pains, for
- each piece of the lining contains only as much of the medicament as necessary for one treatment. It is advantageous to mix the medicament with a disinfectant like thymol in order to prevent any decomposition of the medicament when storing for longer time.
- a disinfectant like thymol in order to prevent any decomposition of the medicament when storing for longer time.
- the lining consists of the above named materials like paper or textile the water contained in the medicament will evaporate after the impregnation and the lining has to be moistened before use so as to make it conductive for the current. This is not necessary if the lining consists of hygroscopic material like hectograph-paste as in this case the lining remains damp permanently.
- a metallic covering serving as electrode.
- This covering may consist of a foil fastened to the lining or be produced on the lining by galvanoplastic depositing or by squirting.
- a lining for the active electrode for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly sufiicient for a single treatment, said lining being substantially free of water capable of evaporating therefrom.
- a lining for the active electrode for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly suflicient for a single treatment, and a thin flexible metallic covering secured to said lining and constituting the active electrode.
Description
Patented July 24, 1934 UNITED STATES DEVICE FOR INSERTING MEDICAMENTS INTO THE BODY BY IONTOPHORESIS Desider Deutsch, Budapest, Hungary, assignor to the firm Schering-Kahlbaum Aktiengesellschaft, Berlin, Germany No Drawing. Application September 4, 1931, Serial No. 561,312. In Germany June 17, 1931 3 Claims.
My invention relates to a device for inserting medicaments into the human or animal body by means of iontophoresis It is known to insert medicaments into the body by iontophoresis. To this end the medicament is put on the skin in fluid state and covered with an electrode connected to one pole of a direct current source while the other pole of said current source is connected to another electrode being in contact with any other part of the body. Thus the current flowing through the electrode and the medicament inserts the latter through the skin into the body. Instead of putting the medicament directly upon the skin it is also known to impregnate a pad of cotton-wool with the medicament and to lay this pad under the one electrode upon the skin. Both methods have several disadvantages. Owing to the poisonous effect of most medicaments if taken in greater quantities or stronger concentration than allowed, the physician must not give them into the hands of the patient but has to perform the iontophoresis himself. That is even true with the treatment of frequently appearing pains wanting repeated iontophoresis like rheumatism, so that the treatment is becoming very dear in spite of its simplicity and of the cheapness of the medicaments.
Moreover the known methods are very unthrifty even if performed by physicians, because usually there is put much more of the medicament upon the cotton-wool than necessary for one treatment and the surplus is getting lost since the same pad of cotton-wool can not be used another time. Besides it often happens that the patient gets burnt by the electric current if the electrode slides off from the wool-cotton and thus comes into direct contact with the skin.
One object of my invention is to provide means for performing the iontophoresis which can be used by everybody without danger of poisoning by the poisonous medicaments necessary therefor.
Another object is to provide a device for the said purpose by which the waste of medicaments is avoided. Another object is to prevent burning of the skin by the current.
My invention consists in a lining for the active electrode for the iontophoresis, said lining consisting of a material being impregnated with the necessary quantity of the medicament. This impregnated lining which may consist of filteringpaper, blotting-paper, textile fabric or the like can be given into the hand of the patient without scruple as wrong use of it is impossible so that the patient is thus enabled to cure his pains, for
example his rheumatism, himself. As the quantity of the medicament in the lining can be adjusted carefully there is no waste and each piece of the lining contains only as much of the medicament as necessary for one treatment. It is advantageous to mix the medicament with a disinfectant like thymol in order to prevent any decomposition of the medicament when storing for longer time. If the lining consists of the above named materials like paper or textile the water contained in the medicament will evaporate after the impregnation and the lining has to be moistened before use so as to make it conductive for the current. This is not necessary if the lining consists of hygroscopic material like hectograph-paste as in this case the lining remains damp permanently.
It is particularly advantageous to combine the lining with the electrode by providing it with a metallic covering serving as electrode. This covering may consist of a foil fastened to the lining or be produced on the lining by galvanoplastic depositing or by squirting. This combination of the lining with the electrode renders the performance of the iontophoresis very simple and easy, and makes it impossible to burn the patient since the electrode can never come into direct contact with the skin.
Having now particularly described and ascertained the nature of my said invention and in what manner the same is to be performed, I declare that what I claim is:
1. As an article of manufacture, for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly sufiicient for a single treatment, said lining being substantially free of water capable of evaporating therefrom.
2. As an article of manufacture, for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly suflicient for a single treatment, and a thin flexible metallic covering secured to said lining and constituting the active electrode.
3. As an article of manufacture, for use in a device for inserting medicaments into the human thin flexible metallic covering secured to said lining and constituting the active electrode, said metallic covering comprising a galvanoplastic deposit.
DESIDER DEUTSCH.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DED61358D DE603705C (en) | 1931-06-18 | 1931-06-18 | Electrode for introducing medicines into the body by means of iontophoresis |
Publications (1)
Publication Number | Publication Date |
---|---|
US1967927A true US1967927A (en) | 1934-07-24 |
Family
ID=6344399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US561312A Expired - Lifetime US1967927A (en) | 1931-06-18 | 1931-09-04 | Device for inserting medicaments into the body by iontophoresis |
Country Status (7)
Country | Link |
---|---|
US (1) | US1967927A (en) |
BE (1) | BE382242A (en) |
DE (1) | DE603705C (en) |
ES (1) | ES127011A1 (en) |
FR (1) | FR725942A (en) |
GB (1) | GB377481A (en) |
NL (1) | NL32493C (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2784715A (en) * | 1953-03-25 | 1957-03-12 | Kestler Otto Colman | Cataphoresis unit |
DE3304246A1 (en) * | 1982-02-09 | 1983-08-18 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | INTERMEDIATE IONTOPHORESIS INSERT, CONTACT SOLUTION AND USE OF A MICROTUBULA INHIBITOR FOR TREATING CHRONIC PAIN SYNDROME |
US4405311A (en) * | 1980-12-08 | 1983-09-20 | Greatbatch Enterprises, Inc. | Method and apparatus for direct electrical injection of gold ions into tissue such as bone |
US4767401A (en) * | 1975-04-22 | 1988-08-30 | Maurice Seiderman | Iontophoretic administration of ionizable or polar medicaments to a mammalian body |
US5415629A (en) * | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
WO1997047353A1 (en) * | 1996-06-13 | 1997-12-18 | Novagent Oy | Composition and system for iontophoretic transdermal delivery of drugs |
US6254883B1 (en) | 1996-01-30 | 2001-07-03 | Novagent Oy | Composition for transdermal delivery of drugs |
US20020142340A1 (en) * | 1986-04-18 | 2002-10-03 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US20030028170A1 (en) * | 1998-08-31 | 2003-02-06 | Birch Point Medical, Inc. | Controlled dosage drug delivery |
US20030199808A1 (en) * | 1999-03-12 | 2003-10-23 | Biophoretic Therapeutic Systems, Llc. | Systems and methods for electrokinetic delivery of a substance |
US20040039328A1 (en) * | 1998-09-15 | 2004-02-26 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
US6735470B2 (en) | 2000-05-31 | 2004-05-11 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US20040111051A1 (en) * | 2000-03-10 | 2004-06-10 | Biophoretic Therapeutic Systems, Llc. | Electrokinetic delivery system for self-administration of medicaments and methods therefor |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2132565B1 (en) * | 1971-04-09 | 1975-10-31 | Bergerioux Madeleine |
-
1931
- 1931-06-18 DE DED61358D patent/DE603705C/en not_active Expired
- 1931-08-19 NL NL58140A patent/NL32493C/xx active
- 1931-08-27 BE BE382242D patent/BE382242A/xx unknown
- 1931-09-02 GB GB24692/31A patent/GB377481A/en not_active Expired
- 1931-09-02 FR FR725942D patent/FR725942A/en not_active Expired
- 1931-09-04 US US561312A patent/US1967927A/en not_active Expired - Lifetime
-
1932
- 1932-06-15 ES ES0127011A patent/ES127011A1/en not_active Expired
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2784715A (en) * | 1953-03-25 | 1957-03-12 | Kestler Otto Colman | Cataphoresis unit |
US4767401A (en) * | 1975-04-22 | 1988-08-30 | Maurice Seiderman | Iontophoretic administration of ionizable or polar medicaments to a mammalian body |
US4405311A (en) * | 1980-12-08 | 1983-09-20 | Greatbatch Enterprises, Inc. | Method and apparatus for direct electrical injection of gold ions into tissue such as bone |
DE3304246A1 (en) * | 1982-02-09 | 1983-08-18 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | INTERMEDIATE IONTOPHORESIS INSERT, CONTACT SOLUTION AND USE OF A MICROTUBULA INHIBITOR FOR TREATING CHRONIC PAIN SYNDROME |
US4602909A (en) * | 1982-02-09 | 1986-07-29 | Richter Gedeon Vegyeszeti Gyar Rt | Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes |
US6989275B2 (en) | 1986-04-18 | 2006-01-24 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US20020142340A1 (en) * | 1986-04-18 | 2002-10-03 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US7008798B2 (en) | 1986-04-18 | 2006-03-07 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US5415629A (en) * | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
US6254883B1 (en) | 1996-01-30 | 2001-07-03 | Novagent Oy | Composition for transdermal delivery of drugs |
WO1997047353A1 (en) * | 1996-06-13 | 1997-12-18 | Novagent Oy | Composition and system for iontophoretic transdermal delivery of drugs |
US7031768B2 (en) | 1998-08-31 | 2006-04-18 | Birch Point Medical, Inc. | Controlled dosage drug delivery |
US20030028170A1 (en) * | 1998-08-31 | 2003-02-06 | Birch Point Medical, Inc. | Controlled dosage drug delivery |
US20040039328A1 (en) * | 1998-09-15 | 2004-02-26 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
US6895271B2 (en) | 1998-09-15 | 2005-05-17 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
US8328788B2 (en) | 1999-03-12 | 2012-12-11 | Nitric Biotherapeutics, Inc. | Methods and systems for electrokinetic delivery of a substance |
US7127285B2 (en) | 1999-03-12 | 2006-10-24 | Transport Pharmaceuticals Inc. | Systems and methods for electrokinetic delivery of a substance |
US20030199808A1 (en) * | 1999-03-12 | 2003-10-23 | Biophoretic Therapeutic Systems, Llc. | Systems and methods for electrokinetic delivery of a substance |
US7016724B2 (en) | 2000-03-10 | 2006-03-21 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system for self-administration of medicaments and methods therefor |
US6792306B2 (en) | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
US20040111051A1 (en) * | 2000-03-10 | 2004-06-10 | Biophoretic Therapeutic Systems, Llc. | Electrokinetic delivery system for self-administration of medicaments and methods therefor |
US8352024B2 (en) | 2000-03-10 | 2013-01-08 | Nitric Biotherapeutics, Inc. | Electrokinetic delivery system for self-administration of medicaments and methods therefor |
US20050182351A1 (en) * | 2000-05-31 | 2005-08-18 | Biophoretic Therapeutic Systems Llc | Electrokinetic delivery of medicaments |
US6735470B2 (en) | 2000-05-31 | 2004-05-11 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US7069073B2 (en) | 2000-05-31 | 2006-06-27 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US20040176737A1 (en) * | 2000-05-31 | 2004-09-09 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
Also Published As
Publication number | Publication date |
---|---|
FR725942A (en) | 1932-05-19 |
NL32493C (en) | 1934-04-16 |
DE603705C (en) | 1934-10-08 |
GB377481A (en) | 1932-07-28 |
BE382242A (en) | 1931-09-30 |
ES127011A1 (en) | 1932-07-16 |
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