US20030032961A1 - Devices from naturally occurring biologically derived materials - Google Patents
Devices from naturally occurring biologically derived materials Download PDFInfo
- Publication number
- US20030032961A1 US20030032961A1 US10/195,719 US19571902A US2003032961A1 US 20030032961 A1 US20030032961 A1 US 20030032961A1 US 19571902 A US19571902 A US 19571902A US 2003032961 A1 US2003032961 A1 US 2003032961A1
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- US
- United States
- Prior art keywords
- bone
- naturally occurring
- barbs
- ecm
- hardness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Definitions
- the present invention relates to devices for attaching, repairing or regenerating orthopedic tissue, particularly to such devices made from naturally occurring extracellular matrix cured or treated to have structural rigidity and hardness.
- ECMs extracellular matrices
- SIS small intestine submucosa
- the SIS material is derived from porcine small intestinal submucosa that models the qualities of its host when implanted in human soft tissues. Further, it is taught that the SIS material provides a natural scaffold-like matrix with a three-dimensional structure and biochemical composition that attracts host cells and supports tissue remodeling.
- SIS products such as OASIS and SURGISIS, are commercially available from Cook Biotech Inc., Bloomington, Ind.
- RESTORE Orthobiologic Implant is available from DePuy Orthopaedics, Inc. in Warsaw, Ind.
- the DePuy product is described for use during rotator cuff surgery, and is provided as a resorbable framework that allows the rotator cuff tendon to regenerate.
- the RESTORE Implant is derived from porcine small intestine submucosa, a naturally occurring ECM (composed of mostly collagen type I (about 90% of dry weight) glycosaminoglycans and other biological molecules), that has been cleaned, disinfected, and sterilized. During seven years of preclinical testing in animals, there were no incidences of infection transmission from the implant to the host, and the RESTORE Implant has not adversely affected the systemic activity of the immune system.
- intestine submucosa While small intestine submucosa is available, other sources of submucosa are known to be effective for tissue remodeling. These sources include, but are not limited to, stomach, bladder, alimentary, respiratory, or genital submucosa, or liver basement membrane. See, e.g., U.S. Pat. Nos. 6,379,710, 6,171,344, 6,099,567, and 5,554,389, hereby incorporated by reference. Further, while SIS is most often porcine derived, it is known that these various submucosa materials may be derived from non-porcine sources, including bovine and ovine sources.
- the ECM material may also include partial layers of laminar muscularis mucosa, muscularis mucosa, lamina basementum, stratum compactum and/or other tissue materials depending upon factors such as the source from which the ECM material was derived and the delamination procedure.
- a naturally occurring ECM to clean and/or comminute the ECM, or to cross-link the collagen within the ECM. It is also within the definition of naturally occurring extracellular matrix to fully or partially remove one or more components or subcomponents of the naturally occurring matrix. However, it is not within the definition of a naturally occurring ECM to extract, separate and purify the natural components or sub-components and reform a matrix material from purified natural components or sub-components. Also, while reference is made to SIS, it is understood that other naturally occurring ECMs (e.g. stomach, bladder, alimentary, respiratory or genital submucosa, and liver basement membrane), whatever the source (e.g.
- bovine, porcine, ovine are within the scope of this invention.
- the terms “naturally occurring extracellular matrix” or “naturally occurring ECM” are intended to refer to extracellular matrix material that has been cleaned, disinfected, sterilized, and optionally cross-linked.
- U.S. Pat. No. 5,352,463 discloses an SIS pillow filled with comminuted SIS for regeneration of a meniscus. While U.S. Pat. No. 5,352,463 contemplates the general concept of meniscus regeneration with an SIS filled pouch, it does not address itself to providing such a pouch having the capability of withstanding the compression and shear stresses involved in an implant for regenerating a meniscus. Also, U.S. Pat. No. 5,352,463 does not contemplate placing structural members formed from naturally occurring ECM, where in the ECM is right and hardened.
- the density and porosity of the extracellular matrix material can be controlled with drying protocols, including air drying, air drying with heat, and air drying with pressure.
- drying protocols including air drying, air drying with heat, and air drying with pressure.
- the ECM material can be dried to have a hardness sufficient to machine the device, without the need to form the device into the general shape by molding.
- various fixation devices can be made having superior material properties, wherein the devices promote healing while remaining biocompatable and biodegradable.
- the present invention in one of its embodiments, is an orthopedic device for attaching soft tissue such as cartilage, ligaments, and tendons to bone.
- the device which in one embodiment has a head end portion configured to engage soft tissue and a body portion configured to engage and attach to the bone, is preferably monolithic and formed as a unitary structure from naturally occurring extracellular matrix.
- the body portion of the device may illustratively terminate with a pointed end distal from the head portion to facilitate the penetration into the bone. Between the pointed distal end and the head portion, the device may illustratively be formed with radially outwardly extending barbs. These barbs may incline toward the head portion to provide a barbed tack or tack-like device.
- a body portion is provided with diametrically opposed flats extending therealong, the flats being generally parallel.
- a mass of naturally occurring ECM may be cured to be very rigid and hardened so that it can be machined using conventional cutting tools and using laser machining.
- the devices of this invention may be formed by machining a mass of cured matrix to define the head portion and body portion.
- the mass may be formed by compressing the ECM into a solid mass.
- the ECM may be comminuted and formed into a solid mass with interlocking strands of ECM.
- a tightly balled or compacted mass of pieces of SIS can be formed by air drying or by hot air drying to become extremely hard.
- this hardened SIS can be machined or formed to have very sharp pointed ends, sharp barbs, etc.
- tacks, barbed tacks, and threaded elements may be machined from such cured mass of SIS.
- the tacks may be double-ended tacks or may include a central head portion and a sharpened body portion extending axially from each end of the head portion.
- a device may be made such that one body portion may be threaded while another body portion has barbs.
- such tacks or barbs may be attached to devices made of naturally occurring extracellular matrix laminated together to form a body portion.
- a body portion may be fabricated to be placed into the tear of a meniscus to extend along the tear.
- One or more tacks or barbs made in accordance with the present invention may be coupled to the body portion to secure the device in the tear.
- Each of these tacks may be made from naturally occurring extracellular matrix cured to be hard and rigid.
- a staple or a staple-like device may be fabricated in accordance with the present invention utilizing two or more spaced apart barbs, each having a sharpened distal end and a proximal end.
- a connecting member may be placed between the proximal ends of the barbs.
- This connecting member may itself be made from a material such as SIS and optionally may be formed integrally with the barbs.
- an orthopedic staple device may be made from naturally occurring extracellular matrix hardened to have two or more sharpened barbs connected by strands of extracellular matrix such as SIS.
- such a staple or staple-like device may be made by laminating several layers of naturally occurring extracellular matrix and curing the layers to form a rigid and hardened sheet-like body.
- the barbs and the connecting member or members are then cut from the body. It has been found that the barbs and connecting member may be cut by laser machining a pattern on the sheet-like body. It has also been found that such barbs may be formed to have edges fused together by the laser machining process.
- a device for anchoring a bone plug in an opening formed in a bone comprises a mass of naturally occurring extracellular matrix formed into a rigid and hardened member configured to be wedged in the opening between the bone plug and the bone.
- This rigid and hardened member may be formed with outwardly extending barbs to dig into the bone plug and the bone.
- the device may also have a connecting portion to extend into an opening in the bone plug.
- the member is designed to extend axially along side the bone plug, and the member may have a plurality of radially outwardly and longitudinally extending fins to dig into the bone plug and the bone.
- the elongated member may be cannulated so that it may be guided into place on a guide member such as a K-wire.
- the member may be formed in the shape of a screw to be threaded into the opening between the bone plug and the bone.
- a method for anchoring a bone plug into an opening formed in a bone for receiving a plug comprising the steps of providing a member formed into a rigid and hardened mass of naturally occurring extracellular matrix and placing the member into the opening between the bone and the bone plug.
- the bone opening will be formed with a cylindrical wall and a bottom (or upper end) to receive a cylindrical bone plug
- the placing step will comprise placing the member in the bone plug to engage the bone plug and the bone.
- the member may be a double-ended tack, one end of which extends into the bottom of the opening and the other end of which extends into the bone plug.
- the double ended tack may radially expand the plug to engage the wall of the opening.
- a device for attaching a soft tissue such as a tendon, ligament, or ligament replacement has been provided.
- the device which is formed from a hardened mass of naturally occurring extracellular matrix, is provided with an elongated body to be received in the opening in the bone.
- the body has a channel therein for receiving a portion of the soft tissue.
- This body is configured to collapse inwardly to grip and hold the soft tissue in the channel when the body is inserted into the opening.
- the body may be threaded to accomplish inserting the device into the opening. It will be appreciated that such a device may be used for attaching an ACL replacement ligament in a tunnel formed in a femur, wherein the tunnel has an axis and a generally cylindrical wall.
- the body may be provided with a generally axial channel for receiving a portion of the ligament replacement to be attached to the femur, and the body may be formed to collapse inwardly to secure the replacement ligament portion in the channel as the device is threaded in the femur tunnel.
- the naturally occurring extracellular matrix may be cured in such a fashion that the device will provide support structure members for various applications in the orthopedic field.
- a device for regenerating a meniscus or a portion thereof may be provided with upper and lower panels and a support structure disposed between the upper and lower panels.
- This support structure may be provided by one or more members of rigid and hardened naturally occurring extracellular matrix.
- the one or more members may comprise a plurality of generally wedge-shaped members, each member having an upper edge supporting the upper panel and a lower edge supported on the lower panel.
- the one or more support members may comprise a lattice of interlocking members, some of which extend radially toward the center of the knee and others of which extend transversely to the radially extending members.
- These members arranged in the lattice structure define a plurality of spaces between the upper and lower panel.
- These spaces may be filled with a biological material to promote regeneration of the meniscus.
- the spaces may be filled with comminuted SIS, a bioactive agent, a biologically-derived agent, cells, a biological lubricant, a biocompatible polymer, a biocompatible inorganic material, or combinations thereof.
- the ECM support structure is believed to provide a framework for meniscus generation.
- one aspect of this disclosure is an orthopedic device for attaching soft tissue such as cartilage, ligament and tendons to bone, the device having a head portion configured to engage soft tissue and a body portion configured to engage and attach to the bone, the head portion and body portion being monolithic and formed from naturally occurring extracellular matrix (ECM) cured to be rigid and hardened to facilitate attachment to the bone.
- ECM extracellular matrix
- Another aspect of this disclosure is an orthopedic tack comprising a head portion and a first body portion formed from naturally occurring extracellular matrix cured to be hard and rigid.
- Yet another aspect of this disclosure is a device for repairing a tear in a cartilaginous surface such as a meniscus, the device comprising strips of naturally occurring extracellular matrix laminated together to form a body portion to be placed down into the tear to extend along the tear, and one or more tacks coupled to the body portion to secure it in the tear, each of the one or more tacks being formed from naturally occurring extracellular matrix.
- Still another aspect of this disclosure is an orthopedic device for attaching or repairing tissue, the device comprising two spaced apart barbs, each barb having a sharpened distal end and a proximal end, and a member connecting the proximal ends of the barbs, the barbs being formed from naturally occurring extracellular matrix
- An additional aspect of this disclosure is a device for anchoring a bone plug in an opening formed in a bone, the device comprising a mass of naturally occurring extracellular matrix formed into a rigid and hardened member configured to be wedged in the opening between the bone plug and the bone.
- Another additional aspect of this disclosure is a method for anchoring a bone plug into an opening formed in a bone for receiving the plug, the method comprising the steps of: providing a member formed into a rigid and hardened mass of naturally occurring extracellular matrix, and placing the member into the opening between the bone plug and the bone.
- Still another aspect of this disclosure is a device for attaching a soft tissue to a bone that has been prepared with an opening to receive the device, the device being formed from a hardened mass of naturally occurring extracellular matrix to form an elongated body to be received in the opening, the body having a channel therein for receiving a portion of the soft tissue, the body being configured to collapse inwardly to grip and hold the soft tissue portion in the channel when the body is inserted into the opening.
- a further aspect of this disclosure is a tack for driving into a bone, the tack having a proximal head end portion, a distal pointed end portion, and an intermediate body portion, the tack being formed from a hardened mass of naturally occurring extracellular matrix.
- a device for regenerating a meniscus or a portion thereof, the device comprising a wedge-shaped body having an upper panel and a lower panel angularly separated to define an apex portion and a base portion, the panels being formed of a naturally occurring extracellular matrix, and a support structure disposed between the upper panel and lower panel, the support structure comprising one or more members of rigid and hardened naturally occurring extracellular matrix.
- One more aspect of this disclosure is an orthopedic device comprising a mass of naturally occurring extracellular matrix or naturally occurring bioremodelable collageneous tissue matrix having a hardness greater than 30 HRD on the Rockwell D Scale.
- a final aspect of this disclosure is a composite orthopedic device comprising two connected portions, each portion comprising naturally occurring extracellular matrix material or naturally occurring bioremodelable collageneous tissue matrix, each portion having a hardness and a density, wherein one portion is configured for anchoring the device to native tissue and has a hardness of no less than 50 HRD on the Rockwell D Scale and a density greater than 0.5 g/cc, and the other portion has a different configuration, a different hardness and a different density.
- FIG. 1 is a perspective view of an orthopedic device for attaching soft tissue such as cartilage, ligaments and tendons to bone, the device having a head portion configured to engage the soft tissue and a body portion configured to engage and attach to the bone;
- FIG. 2 is a side view of the device of FIG. 1;
- FIG. 3 is an end view of the device looking along the lines 3 - 3 in FIG. 2;
- FIG. 4 is a side view of a device similar to the FIG. 1 device except that it is elongated;
- FIG. 5 is a side view of the double-ended tack device
- FIG. 6 is a side view of a double-ended device, one end configured as a tack with barbs and the other end being threaded;
- FIG. 7 is an end view of the device shown in FIG. 6 looking along the lines 7 - 7 ;
- FIG. 8 is a side view of an elongated tack-like device
- FIG. 9 is a side view of a tack-like device used to hold tissue in an opening formed in a bone
- FIG. 10 is a partially sectioned side view of a tack-like device with a central core filled with comminuted ECM material;
- FIG. 11 is a side view of a tack-like device with a design somewhat different from the FIG. 1 design;
- FIG. 12 is an end view of the FIG. 11 device looking along the lines 12 - 12 in FIG. 11.
- FIG. 13 is a perspective view of a device configured to collapse on soft tissue as the device is inserted into an opening in a bone;
- FIG. 14 shows the device of FIG. 13 inserting soft tissue into bone.
- FIG. 15 is a top view of the FIG. 16 device looking along the lines 1515 in FIG. 16.
- FIG. 16 is similar to the FIG. 13 device with helical thread segments to facilitate threading the device into an opening in a bone;
- FIG. 17 is a diagrammatical drawing showing how the device of FIG. 6 may be threaded into a bone plug and then how the bone plug may be inserted into the opening in a bone;
- FIG. 18 is a sectional view showing the bone plug of FIG. 17 installed in the bone with the double-ended device of FIG. 6;
- FIG. 19 shows a double-ended tack made in accordance with the present invention used to insert and hold a bone plug into an opening
- FIG. 20 shows a sectional view of the bone plug of FIG. 19 after insertion
- FIG. 21 shows an elongated and cannulated device which has a generally triangular cross-section with relatively sharp side edges to be driven between a bone plug and an opening in which the plug is inserted.
- FIG. 22 is a perspective view of a device similar to the FIG. 21 device except that it has a generally square cross-section with four relatively sharp side edges;
- FIG. 23 shows a perspective view of how the devices of FIGS. 21 and 22 may be driven to wedge between a bone plug and a bone opening to anchor the bone plug;
- FIG. 24 shows a device using barbs made in accordance with the present invention to hold a bone plug into an opening formed in the bone
- FIG. 25 shows an end view of the bone plug of FIG. 24 inserted into the bone opening
- FIG. 26 shows a staple-like device made in accordance with the present invention.
- FIG. 27 shows a variation on the staple-like device of FIG. 26
- FIG. 28 shows how a staple-like device may be cut from laminated layers of ECM material
- FIG. 29 shows a laminated body of ECM material held in position by tack-like devices
- FIG. 29( a ) shows the device of FIG. 29 without a connecting member between the tacks
- FIG. 30 shows a perspective view of staple-like devices shown in FIGS. 26 and 27 used to hold a sheet-like body of ECM material in a tear in a meniscus;
- FIG. 31 shows a three-barbed staple device which may be cut from laminated layers of ECM material to have a desired pattern
- FIG. 32 shows a device similar to FIG. 31, but having a different pattern.
- FIGS. 1 - 3 show an orthopedic device 10 for attaching soft tissue such as cartilage, ligaments, tendons to bone, the device having a head portion 12 configured to engage soft tissue and a body portion 14 configured to engage and attach to the bone.
- the head portion 12 and body portion 14 are illustratively monolithic and formed from naturally occurring extracellular matrix cured to be rigid and hardened to facilitate attachment to the bone.
- the body portion 14 terminates with a pointed end 16 distal from the head portion 12 to facilitate penetration into the bone.
- the ECM material from which the device 10 is fabricated will be cured to be hardened and toughened such that the device 10 may be driven into bone tissue.
- the pointed end 16 with its hardness and toughness will facilitate insertion into the bone.
- the body portion 14 between the pointed end 16 and the head portion 12 , is provided with radially outwardly extending barbs or barb portions 20 , 22 , which are illustratively inclined toward the head portion.
- These portions 20 , 22 are illustratively defined by machining or forming diametrically opposed flats 24 , 26 on the body portion 14 , the flats being generally parallel. As best seen in FIG. 3, flats 24 are formed on diametrically opposite sides of the barb portion 20 while the flats 26 are formed on the diametrically opposite sides of the barb portion 22 .
- the device of FIGS. 1 - 3 and other similar devices disclosed herein may be fabricated by compacting comminuted or shredded naturally occurring ECM material into bar or rod stock by curing the material such that it is very rigid and hardened.
- the curing may be accomplished by air drying comminuted ECM at room temperature for several days.
- Comminuted ECM when dried at room temperature for several days, becomes very tough and hard and can be machined using conventional tools.
- a sample of 3 cc of comminuted SIS that has been air dried at room temperature for several days produced a piece of SIS stock that is 7-8 mm in diameter and 2 mm thick, and has a hardness of about 70 HRD on the “Rockwell D” scale.
- an orthopaedic device is formed from comminuted SIS that has been air dried at room temperature for several days.
- the SIS has a hardness of at least 30 HRD on the “D” scale, particularly at least 50 on the “D” scale, more particularly above 60 HRD on the “D” scale, and most particularly about 70 HRD or above on the “D” scale.
- a hardness of 60-70 is usable in many applications.
- Drying and hardening may be accelerated by using heat and/or pressure.
- the ECM may be comminuted using a COMITROL machine from Urschel Laboratories (Valparaiso, Ind.), with a Vericut sealed impeller at 9391 rpm.
- the bar stock or rod stock may be machined with conventional machine shop equipment to the desired shapes.
- the device 10 may be turned on a lathe or similar equipment to produce the head portion 12 and the body portion 14 with its generally conical barb portions 20 , 22 .
- the flats 24 , 26 may be separately machined such that the conical portions 20 , 22 will become more barb-like.
- various barb configurations may be formed on the device 10 , for example, by cutting longitudinally extending slots in the body portion 14 to provide more radially outwardly barbs inclined axially toward the head portion 12 .
- tacks or tack-like devices may be made as shown in FIGS. 1 - 3 such that they can be driven into bone tissue to be securely anchored in the tissue.
- the head portion 12 of such devices 10 may trap soft tissue against the bone surface.
- the head portion 12 may have a larger diameter than proportionately shown in FIGS. 1 - 3 and that the head portion 12 may have a shape other than the circular shape depicted in FIGS. 1 - 3 .
- the head portion 12 itself may be provided with a roughened or barbed surface facing end 16 to attach to the soft tissue being anchored. It will be appreciated that a plurality of devices 10 may be used to secure soft tissue to bone.
- FIG. 4 shows a device 30 , similar to the device 10 of FIGS. 1 - 3 except that the device 30 is longer.
- the device 30 in FIG. 4 has a head portion 12 , a body portion 14 , and a pointed distal end 16 .
- the device 30 has three barb portions and three sets of flats. The device 30 , of course, is to be driven further into the bone structure than the device 10 .
- FIG. 5 shows a device 36 which is essentially a double-ended tack, each end of which is similar to the device 10 with a common head portion 12 , having an illustrative proportionately larger diameter than the head portion 12 of FIGS. 1 - 3 .
- the device 36 of FIG. 5 is provided so that one of its body portions 14 may be inserted into one bone or tissue structure while the other body portion 14 may be inserted into another bone or tissue structure.
- the diameter of the head portion 12 of the device 36 may be made smaller or larger depending on the attachment application.
- FIG. 6 shows a device 40 which is a double-ended device similar to device 36 of FIG. 5 except that one body portion 42 is threaded.
- the device 40 has another body portion 14 similar to the body portion 14 of FIGS. 1 - 3 , with a threaded opposite end portion 42 .
- the head portion 44 of the device 40 may be hexagonal as illustrated or otherwise formed to provide a drive portion for inserting the device. It will be appreciated that a surgeon will be provided with a tubular socket to receive and drivingly engage the head portion 44 .
- the illustrative device 40 which may be cannulated as indicated at broken lines 46 so that the device 40 may be accurately positioned on a K-wire, may optionally have its threaded end provided with diametrically opposed flats 48 (FIG. 7). These flats 48 serve to impede rotation subsequent to implantation.
- FIG. 8 shows a tack 60 with a head portion 62 and an elongated body portion 64 having a distal end 66 that is somewhat sharpened to a point.
- the tack 60 in FIG. 8 is provided with a pair of longitudinally spaced apart, circumferential ridges 68 between the distal end 66 and the head portion 62 . These circumferential ridges 68 serve to lock the device into the surrounding native tissue (i.e. bone).
- a device 70 shown in FIG. 10 is similar to devices 10 and 30 except that the proximal body portion 72 including the head 74 is formed with a central bore or opening 76 which may be filled with a mass of comminuted naturally occurring ECM. This central bore space 76 in the device 70 is therefore filled with a biological material to provide a framework for more rapid resorption.
- a device 80 is shown in FIGS. 11 and 12 to have a head portion 82 , a body portion 84 with a distal sharpened end 85 . It will be appreciated that the device 80 is similar to the prior devices except that body portion 84 is formed to have three angularly spaced rows of barbs 86 formed at least in part by three angularly spaced apart, longitudinally extending grooves 88 best seen in FIG. 12. It will be appreciated that the barbs 86 are formed to extend radially outwardly from the body portion 84 and inclined axially toward the head portion 82 .
- barbs 86 and the barbs 20 , 22 in the above-described devices 10 , 30 , 36 , 40 and 70 illustratively have an abrupt or sharp edge facing the head portions of the device. It will be appreciated that when the devices are inserted into a bone, the bone will close in on the body portions and these abrupt axially outwardly facing edges of the barbs to secure the devices in the bone.
- the head portion 82 is shown having three angularly spaced notches 90 , which are provided to aid in grasping in delivery of the device. Other configurations are within the scope of this invention.
- FIG. 9 illustrates a device 96 , which may be cannulated as indicated at broken lines 98 , for insertion in the bone to hold soft tissue.
- device 96 is provided with a plurality of barbs 92 , 93 , 94 .
- the device as shown in FIG. 9 illustratively may be used, for example, as an interference screw for wedging a bone plug into a bone tunnel, such as for fixing a replacement ligament into the bone tunnel.
- FIGS. 1 - 9 The designs shown in FIGS. 1 - 9 , therefore, provide an orthopaedic tack or barbed tack fabricated from naturally occurring ECM that has been cured to be hard and rigid.
- These devices 10 , 30 , 36 , 40 , 60 , 70 , 80 , and 96 may be fabricated from SIS which is cured to be hard and rigid by comminuting the SIS and allowing the comminuted SIS to air dry.
- a device 110 is provided for attaching a soft tissue such as a ligament or a tendon to a bone is shown in FIGS. 13 - 15 , the device being formed from a hardened mass of naturally occurring ECM to have an elongated body to be received in an opening formed in the bone.
- the device 110 has a head portion 112 , a central body portion 114 and a distal end 116 all shaped and configured for insertion into a bone opening having a diameter smaller than the largest diameter of the central body portion 114 .
- the device 110 is also provided with a central, longitudinal extending channel 118 extending axially through the device.
- the illustrative device 110 is further formed with axially and radially extending cut-out or slot 120 which opens from the channel 118 to the exterior of the device 110 .
- a piece of soft tissue which may be a ligament, a tendon, or a ligament graft such as an ACL graft, may be inserted axially into the channel 118 to be carried with the device 110 into the bone.
- the device 110 is formed from a hardened mass of naturally occurring ECM, it is configured for being forced into an opening prepared in a bone, and to collapse inwardly to grip the soft tissue 122 in the channel 118 .
- the interior of the channel 118 may be provided with a roughened texture or even interior barbs or gripping surfaces to grip the soft tissue 122 more securely as the device 110 collapses radially inwardly.
- Central body portion 114 is provided with three radially outwardly extending frustcoconical engagers 124 which serve to anchor the device 110 in the bone. These engagers 124 have outer surfaces which incline axially toward the head portion 112 and radially outwardly. As the device 110 is driven into the bone opening, these engagers 124 will cause the device to collapse inwardly by bringing the longitudinal walls of the cut-out 120 closer together, reducing the diameter of the channel 118 , and holding soft tissue 122 securely within bone 128 , as shown in FIG. 14.
- the engagers 124 as illustrated in FIG. 13, have abrupt radially outwardly extending and axially facing surfaces for anchoring the device 110 in the bone opening.
- the device 130 may be formed as a threaded device as shown in FIGS. 15 - 16 with helical thread segments replacing the engagers 144 on the central body portion 134 .
- the device 130 is so threaded, and the head end portion 132 with the hex-shaped cuts 146 is engaged with a socket driver, with the driver end preferably formed on a tube for receiving the soft tissue graft 142 , the device 130 can be threaded into a bone opening.
- FIGS. 17 and 18 show diagrammatically how the device 40 of FIGS. 6 and 7 can be used to anchor a bone plug 150 into an opening 152 drilled or otherwise formed in a bone.
- the threaded body portion 42 of the device 40 may be threaded into a central opening in the bone plug 150 as depicted in FIGS. 17 and 18.
- the opening 152 in the bone may be provided at a diameter which will snugly receive the bone plug 150 .
- the barbed portion (body portion 14 ) of device 40 is provided to anchor into the bottom of the opening 152 . It may be advantageous to provide a central pilot hole 154 in the bottom of the opening 152 to receive and guide the body portion 14 of the device 40 .
- the method and device in FIGS. 17 and 18 may be used to anchor a cartilage plug 156 into a bone.
- a defect in the cartilage in the surface of a bone such as on the condyle of a knee, will be removed by forming the opening 152 for receiving the bone plug 150 .
- a cartilage graft 156 will be secured to the bone plug 150 to be used to close the opening 158 made in the cartilage layer 160 in the bone.
- the bone plug 150 and the anchoring device 140 may be used to hold a cartilage plug 156 in position in an opening 158 in cartilage 160 such that cartilage plug 156 lies in an essentially contiguous plane with the undamaged surrounding cartilage 168 .
- FIGS. 19 and 20 show how a bone plug 170 , which is illustratively formed as a cylindrical bone plug to be anchored into a cylindrical opening 172 in a bone, may be used with the device 36 shown in FIG. 5.
- the bone opening 172 is provided with a depth sufficient to receive a plug 170
- the bottom 175 of the opening 172 is provided with a pilot hole 174 .
- the plug 170 is prepared with a split end as indicated at 176 and a central pilot opening 178 at bottom surface 179 , for facing bottom 175 of opening 172 .
- FIG. 20 shows the device 36 with one of its end portions 14 anchored into the bone in the bottom of the opening 172 .
- FIGS. 21 and 22 show devices 180 , 190 for use in anchoring bone plugs in openings formed in bones.
- the devices 180 , 190 may be formed from naturally occurring extracellular matrix cured to be rigid and hardened.
- the device 180 is elongated on a central axis indicated at 182 and may be cannulated on the axis as indicated at 184 .
- the device 180 may be slid onto a K-wire and located accurately between the outer wall of a bone plug and the inner wall of an opening in which the bone plug is to be anchored.
- the illustrative device 180 has a generally triangular cross-section providing three longitudinally extending sharpened edges 183 for cutting into the exterior of the bone plug and the interior of the bone opening.
- the device 180 may be forced into the space between the exterior of the bone plug and the wall of the opening to extend along the bone plug and wedge the bone plug into firm engagement with the bone opening.
- the device 190 which is formed about the axis 192 and which may also be cannulated as indicated at 194 , is formed to be have a generally square cross-section providing four longitudinally extending side edges 193 to cut into the exterior of the bone plug and the interior of the bone opening.
- bone plugs may take various cross-sectional shapes determined by the instruments used to cut the plugs and the particular surgical need.
- a bone plug harvested on the end of a patellar tendon strip in a tunnel formed upwardly into the femur.
- the patellar tendon is harvested with a bone plug on one end of the strip. The other end may be provided with a bone plug as well.
- This patellar strip is then used as an ACL graft replacement.
- a tunnel is formed upwardly through a tibial platform into the femur and the ACL graft is secured in place by anchoring one of the bone plugs in the femur and the other of the bone plugs in the tibia.
- cannulated screws are threaded into the openings to extend alongside the bone plugs.
- FIG. 23 shows only a portion of a ACL graft attached to the plug 200 .
- a bone plug 210 may be secured in a tunnel 212 by barbed anchors 214 .
- Each of these barbed anchors 214 may be formed from hardened naturally occurring ECM to have sharp barbs 216 , 218 with a connector portion 220 having a right angle extension 220 to be received into an opening 222 in the bone plug 210 .
- the barbed anchors 214 may be attached to the bone plug 210 to extend along side the bone plug as it is inserted into the tunnel 212 .
- An ACL graft may be attached to the bone plug 210 as indicated at 224 .
- the devices are made from ECM that has been cured to a hardness to allow machining. Each of these devices retains its structural integrity for a sufficient period of time to allow the intended orthopaedic fixation, and to permit bone or cartilage ingrowth or repair to begin.
- the devices such as devices 180 , 190 and anchors 214 in FIGS. 23 - 25 as well as the devices 10 , 30 , 36 , 40 , 60 , 70 , 80 , 96 , and 110 are designed to be absorbed into the host tissue, bone, or soft tissue into which they are placed.
- an orthopedic device 240 for attaching or repairing tissue comprising two spaced apart barb portions 242 , 244 , each of which has a proximal end portion 246 , a sharpened distal end portion 248 , and at least one barb 243 .
- the device 240 has a connecting member 250 extending between the proximal ends 246 to provide a staple-like device.
- Each of the barb portions 242 , 244 may be formed as previously discussed from hardened and rigid naturally occurring ECM.
- the entire device 240 may be machined from a single block of hardened ECM.
- barb portions 242 , 244 and connecting member 250 may be machined separately, and the connecting member 250 may have its ends inserted into and joined into the proximal end portions 246 of the barb portions as indicated at 252 .
- Connecting member 250 may be affixed to the barb portions 242 , 244 in any number of ways, including threading or gluing at insertion 252 .
- the device 240 therefore, may be used as a staple, for example, with the barb portions 242 , 244 inserted into the bone and the connecting member 250 holding tissue to the bone.
- the connecting member 250 may be formed from hardened naturally occurring ECM, flexible ECM, or another material.
- FIG. 27 shows a device 260 with similar spaced apart barb portions 242 , 244 and a connecting member 262 which is hollow and filled with comminuted SIS.
- FIG. 28 shows an approach for making a staple or staple-like device 270 having spaced apart barb portions 272 , 274 and a connecting member 276 .
- the device 270 contemplates that a plurality of layers of naturally occurring ECM material will be laminated together to be cured by air drying to form a rigid and hardened plate-like body. Then, a laser machine unit 278 will be programmed to cut a pattern which will produce a device 270 from the laminated layers of ECM. It has been found that such laser cutting of several layers of ECM will produce barb portions 272 , 274 having cut edges which are sealed and fused together to enhance the attachment capability of the barbs 273 .
- Device 270 may optionally have a plurality of laser cut holes 275 , which further fuse together the layers of ECM.
- FIGS. 31 and 32 show devices 280 and 290 , respectively, with different patterns cut from such laminated layers of rigid and hardened naturally occurring ECM.
- the device 280 is shown having three spaced apart barb portions 282 , 284 , 286 with a bowed or curved connecting member 288 extending between the proximal ends of the barb portions.
- the device 290 in FIG. 32 is shown as having three spaced apart barb portions 292 , 294 and 296 with a member 298 connecting the proximal ends of the barbs.
- the barb portions 282 , 284 , 286 and the connecting member 288 may all lie in a common plane.
- the connecting member 288 may be warped or curved so that the barb portions 282 , 284 , 286 do not necessarily lie in a common plane.
- the barb portions 292 , 294 , 296 initially start out being parallel and lying in a common plane. It will be appreciated that the connecting member 298 may be manipulated by the surgeon to relocate the direction of the barb portions 292 , 294 , 296 .
- FIG. 29 shows the staple-like device 310 comprising a pair of spaced apart barb portions 312 , 314 formed as discussed above. These barb portions 312 , 314 are connected by a connecting member 316 extending between the proximal ends of the barb portions.
- the device 310 comprises strips of naturally occurring ECM laminated together to form a body portion 320 to be placed down into a tear in a cartilaginous surface such as a meniscus.
- the barbs 313 hold the body 320 in the tear. It is contemplated that the ends of the body 320 will be attached securely to the barb portions 312 , 314 .
- One method of attaching body 320 to barb portions 312 , 314 is to insert edges of the body 320 into slots provided in body portions 312 , 314 .
- the barbs may be provided with a slit for receiving and gripping and holding the ends of the body 320 . It is contemplated that, once the device 310 is fully inserted in the meniscus tear and attached with the barb portions 312 , 314 , the connecting member 316 and the upper ends of the barb portions may be cut away leaving a structure such as that shown in FIG. 29( a ).
- the body portion 320 may have characteristics different from those of the barb portions 312 , 314 .
- the body portion 320 may have a greater porosity or lower density or lower hardness than the barb portions, and may have characteristics similar to those of commercial products like the RESTORE patch, for example. It should be understood that these possible differences in characteristics are provided by way of example only; the illustrated embodiments are not intended to limit the material for the body portion 320 .
- FIG. 30 shows a device 340 comprising a body such as the body 320 made from laminating layers of naturally occurring ECM together.
- the ends of the body 320 in the device 340 are attached to the connecting members 250 similar to two devices 240 or 260 as shown in FIGS. 26 and 27.
- the hardened ECM devices of the present invention can be combined with one or more bioactive agents (in addition to those already present in naturally occurring ECM), one or more biologically-derived agents or substances, one or more cell types, one or more biological lubricants, one or more biocompatible inorganic materials, one or more biocompatible synthetic polymers and one or more biopolymers. Moreover, the hardened ECM devices of the present invention can be combined with devices containing such materials.
- Bioactive agents include one or more of the following: chemotactic agents; therapeutic agents (e.g. antibiotics, steroidal and non-steroidal analgesics and anti-inflammatories, anti-rejection agents such as immunosuppressants and anticancer drugs); various proteins (e.g. short chain peptides, bone morphogenic proteins, glycoprotein and lipoprotein); cell attachment mediators; biologically active ligands; integrin binding sequence; ligands; various growth and/or differentiation agents (e.g.
- epidermal growth factor IGF-I, IGF-II, TGF- ⁇ I-III, growth and differentiation factors, vascular endothelial growth factors, fibroblast growth factors, platelet derived growth factors, insulin derived growth factor and transforming growth factors, parathyroid hormone, parathyroid hormone related peptide, bFGF; TGF ⁇ superfamily factors; BMP-2; BMP-4; BMP-6; BMP-12; sonic hedgehog; GDF5; GDF6; GDF8; PDGF); small molecules that affect the upregulation of specific growth factors; tenascin-C; hyaluronic acid; chondroitin sulfate; fibronectin; decorin; thromboelastin; thrombin-derived peptides; heparin-binding domains; heparin; heparan sulfate; DNA fragments and DNA plasmids. If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these
- Bioly derived agents include one or more of the following: bone (autograft, allograft, and xenograft) and derivates of bone; cartilage (autograft, allograft, and xenograft), including, for example, meniscal tissue, and derivatives; ligament (autograft, allograft, and xenograft) and derivatives; derivatives of intestinal tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of stomach tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of bladder tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of alimentary tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of respiratory tissue (autograft, allograft, and xenograft), including for
- biologically derived agents Purified ECM and other collagen sources are also intended to be included within “biologically derived agents.” If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the present invention, and such substances should be included in the meaning of “biologically-derived agent” and “biologically-derived agents” unless expressly limited otherwise.
- Bioremodelable collageneous tissue matrices also include bioremodelable collageneous tissue matrices.
- the expressions “bioremodelable collagenous tissue matrix” and “naturally occurring bioremodelable collageneous tissue matrix” include matrices derived from native tissue selected from the group consisting of skin, artery, vein, pericardium, heart valve, dura mater, ligament, bone, cartilage, bladder, liver, stomach, fascia and intestine, tendon, whatever the source.
- bioremodelable collageneous tissue matrix is intended to refer to matrix material that has been cleaned, processed, sterilized, and optionally crosslinked, it is not within the definition of a naturally occurring bioremodelable collageneous tissue matrix to purify the natural fibers and reform a matrix material from purified natural fibers.
- bioremodelable collageneous tissue matrices includes “extracellular matrices” within its definition.
- Cells include one or more of the following: chondrocytes; fibrochondrocytes; osteocytes; osteoblasts; osteoclasts; synoviocytes; bone marrow cells; mesenchymal cells; stromal cells; stem cells; embryonic stem cells; precursor cells derived from adipose tissue; peripheral blood progenitor cells; stem cells isolated from adult tissue; genetically transformed cells; a combination of chondrocytes and other cells; a combination of osteocytes and other cells; a combination of synoviocytes and other cells; a combination of bone marrow cells and other cells; a combination of mesenchymal cells and other cells; a combination of stromal cells and other cells; a combination of stem cells and other cells; a combination of embryonic stem cells and other cells; a combination of precursor cells isolated from adult tissue and other cells; a combination of peripheral blood progenitor cells and other cells; a combination of stem cells isolated from adult tissue and other cells; and
- a sterilized implant may be subsequently seeded with living cells and packaged in an appropriate medium for the cell type used.
- a cell culture medium comprising Dulbecco's Modified Eagles Medium (DMEM) can be used with standard additives such as non-essential amino acids, glucose, ascorbic acid, sodium pyrovate, fungicides, antibiotics, etc., in concentrations deemed appropriate for cell type, shipping conditions, etc.
- DMEM Dulbecco's Modified Eagles Medium
- Bio lubricants include: hyaluronic acid and its salts, such as sodium hyaluronate; glycosaminoglycans such as dermatan sulfate, heparan sulfate, chondroiton sulfate and keratan sulfate; synovial fluid and components of synovial fluid, including mucinous glycoproteins (e.g. lubricin), tribonectins, articular cartilage superficial zone proteins, surface-active phospholipids, lubricating glycoproteins I, II; vitronectin; and rooster comb hyaluronate.
- mucinous glycoproteins e.g. lubricin
- tribonectins e.g. lubricin
- articular cartilage superficial zone proteins e.g. articular cartilage superficial zone proteins
- surface-active phospholipids e.g. lubricating glycoproteins I, II
- vitronectin
- Bio lubricant is also intended to include commercial products such as ARTHREASETM high molecular weight sodium hyaluronate, available in Europe from DePuy International, Ltd. of Leeds, England, and manufactured by Bio-Technology General (Israel) Ltd., of Rehovot, Israel; SYNVISC® Hylan G-F 20, manufactured by Biomatrix, Inc., of Ridgefield, N.J.
- HYLAGAN® sodium hyaluronate available from Sanofi-Synthelabo, Inc., of New York, N.Y., manufactured by FIDIA S.p.A., of Padua, Italy
- HEALON® sodium hyaluronate available from Pharmacia Corporation of Peapack, New Jersey in concentrations of 1%, 1.4% and 2.3% (for ophthalmologic uses).
- Biocompatible polymers is intended to include both synthetic polymers and biopolymers (e.g. collagen).
- biocompatible polymers include: polyesters of [alpha]-hydroxycarboxylic acids, such as poly(L-lactide) (PLLA) and polyglycolide (PGA); poly-p-dioxanone (PDS); polycaprolactone (PCL); polyvinyl alcohol (PVA); polyethylene oxide (PEO); polymers disclosed in U.S. Pat. Nos. 6,333,029 and 6,355,699; and any other bioresorbable and biocompatible polymer, co-polymer or mixture of polymers or co-polymers that are utilized in the construction of prosthetic implants.
- polyesters of [alpha]-hydroxycarboxylic acids such as poly(L-lactide) (PLLA) and polyglycolide (PGA); poly-p-dioxanone (PDS); polycaprolactone (PCL); polyvinyl alcohol (PVA); polyethylene oxide (PEO); polymers
- Biocompatible inorganic materials include materials such as hydroxyapatite, all calcium phosphates, alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium carbonate, barium carbonate, calcium sulfate, barium sulfate, polymorphs of calcium phosphate, sintered and non-sintered ceramic particles, and combinations of such materials. If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the present invention, and such substances should be included in the meaning of “biocompatible inorganic material” and “biocompatible inorganic materials” unless expressly limited otherwise.
- bioactive agents biologically derived agents, cells, biological lubricants, biocompatible inorganic materials, biocompatible polymers can be used with the hardened ECM devices of the present invention.
- the hardened ECM devices of the present invention can also be combined with other devices that include naturally occurring ECM, and it is expected that the hardened ECM devices can be combined with purified ECM and commercially available collagen materials and/or with devices that contain purified ECM and commercially available collagen materials.
- implants can be made as composites of materials of different characteristics.
Abstract
Orthopaedic devices are disclosed. The devices include a part that is made of extracellular matrix material that has been hardened. One method of hardening the extracellular matrix is to comminute naturally occurring extracellular matrix and dry the comminuted material. The hardened extracellular matrix material can be machined to form a variety of orthopaedic devices.
Description
- This application claims priority to U.S. Patent Application No. 60/389,028, filed Jun. 14, 2002, and U.S. Provisional Application No. 60/305,786, filed Jul. 16, 2001, hereby incorporated by reference.
- Cross reference is made to copending U.S. patent applications Serial No. ______ entitled “Meniscus Regeneration Device and Method” (Attorney Docket No. 265280-71141, DEP-745); Serial No. ______ entitled “Cartilage Repair Apparatus and Method” (Attorney Docket No. 265280-71143, DEP-749); Serial No. ______ entitled “Unitary Surgical Device and Method” (Attorney Docket No. DEP-750); Serial No. ______ entitled “Hybrid Biologic/Synthetic Porous Extracellular Matrix Scaffolds” (Attorney Docket No. 265280-71144, DEP-751); Serial No. ______ entitled “Cartilage Repair and Regeneration Device and Method” (Attorney Docket No. 265280-71145, DEP-752); Serial No. ______ entitled “Porous Extracellular Matrix Scaffold and Method” (Attorney Docket No. 265280-71146, DEP-747); Serial No. ______ entitled “Cartilage Repair and Regeneration Scaffolds and Method” (Attorney Docket No. 265280-71180, DEP-763); and Serial No. ______ entitled “Porous Delivery Scaffold and Method” (Attorney Docket No. 265280-71207, DEP-762), each of which is assigned to the same assignee as the present application, each of which is filed concurrently herewith, and each of which is hereby incorporated by reference. Cross reference is also made to U.S. patent application Ser. No. 10/172,347 entitled “Hybrid Biologic-Synthetic Bioabsorbable Scaffolds” which was filed on Jun. 14, 2002, which is assigned to the same assignee as the present application, and which is hereby incorporated by reference.
- The present invention relates to devices for attaching, repairing or regenerating orthopedic tissue, particularly to such devices made from naturally occurring extracellular matrix cured or treated to have structural rigidity and hardness.
- It is known to use various collagen scaffolds to provide a scaffold for repair and regeneration of damaged tissue. U.S. Pat. No. 6,042,610 to ReGen Biologics, hereby incorporated by reference, discloses the use of a device comprising a bioabsorbable material made at least in part from purified natural fibers. The purified natural fibers are cross-linked to form the device of U.S. Pat. No. 6,042,610. The device can be used to provide augmentation for a damaged meniscus. Related patents U.S. Pat. No. 5,735,903, 5,479,033, 5,306,311, 5,007,934, and 4,880,429 also disclose a meniscal augmentation device for establishing a scaffold adapted for ingrowth of meniscal fibrochondrocyts.
- It is also known to use naturally occurring extracellular matrices (ECMs) to provide a scaffold for tissue repair and regeneration. One such ECM is small intestine submucosa (SIS). SIS has been described as a natural acellular biomaterial used to repair, support, and stabilize a wide variety of anatomical defects and traumatic injuries. See, for example, Cook® Online New Release provided by Cook Biotech Inc. at “www.cookgroup.com”. The SIS material is derived from porcine small intestinal submucosa that models the qualities of its host when implanted in human soft tissues. Further, it is taught that the SIS material provides a natural scaffold-like matrix with a three-dimensional structure and biochemical composition that attracts host cells and supports tissue remodeling. SIS products, such as OASIS and SURGISIS, are commercially available from Cook Biotech Inc., Bloomington, Ind.
- Another SIS product, RESTORE Orthobiologic Implant, is available from DePuy Orthopaedics, Inc. in Warsaw, Ind. The DePuy product is described for use during rotator cuff surgery, and is provided as a resorbable framework that allows the rotator cuff tendon to regenerate. The RESTORE Implant is derived from porcine small intestine submucosa, a naturally occurring ECM (composed of mostly collagen type I (about 90% of dry weight) glycosaminoglycans and other biological molecules), that has been cleaned, disinfected, and sterilized. During seven years of preclinical testing in animals, there were no incidences of infection transmission from the implant to the host, and the RESTORE Implant has not adversely affected the systemic activity of the immune system.
- While small intestine submucosa is available, other sources of submucosa are known to be effective for tissue remodeling. These sources include, but are not limited to, stomach, bladder, alimentary, respiratory, or genital submucosa, or liver basement membrane. See, e.g., U.S. Pat. Nos. 6,379,710, 6,171,344, 6,099,567, and 5,554,389, hereby incorporated by reference. Further, while SIS is most often porcine derived, it is known that these various submucosa materials may be derived from non-porcine sources, including bovine and ovine sources. Additionally, the ECM material may also include partial layers of laminar muscularis mucosa, muscularis mucosa, lamina propria, stratum compactum and/or other tissue materials depending upon factors such as the source from which the ECM material was derived and the delamination procedure.
- For the purposes of this invention, it is within the definition of a naturally occurring ECM to clean and/or comminute the ECM, or to cross-link the collagen within the ECM. It is also within the definition of naturally occurring extracellular matrix to fully or partially remove one or more components or subcomponents of the naturally occurring matrix. However, it is not within the definition of a naturally occurring ECM to extract, separate and purify the natural components or sub-components and reform a matrix material from purified natural components or sub-components. Also, while reference is made to SIS, it is understood that other naturally occurring ECMs (e.g. stomach, bladder, alimentary, respiratory or genital submucosa, and liver basement membrane), whatever the source (e.g. bovine, porcine, ovine) are within the scope of this invention. Thus, in this application, the terms “naturally occurring extracellular matrix” or “naturally occurring ECM” are intended to refer to extracellular matrix material that has been cleaned, disinfected, sterilized, and optionally cross-linked.
- The following U.S. patents, hereby incorporated by reference, disclose the use of ECMs for the regeneration and repair of various tissues: U.S. Pat. Nos. 6,379,710; 6,187,039; 6,176,880; 6,126,686; 6,099,567; 6,096,347; 5,997,575; 5,993,844; 5,968,096; 5,955,110; 5,922,028; 5,885,619; 5,788,625; 5,762,966; 5,755,791; 5,753,267; 5,733,337; 5,711,969; 5,645,860; 5,641,518; 5,554,389; 5,516,533; 5,445,833; 5,372,821; 5,352,463; 5,281,422; and 5,275,826. U.S. Pat. No. 5,352,463 discloses an SIS pillow filled with comminuted SIS for regeneration of a meniscus. While U.S. Pat. No. 5,352,463 contemplates the general concept of meniscus regeneration with an SIS filled pouch, it does not address itself to providing such a pouch having the capability of withstanding the compression and shear stresses involved in an implant for regenerating a meniscus. Also, U.S. Pat. No. 5,352,463 does not contemplate placing structural members formed from naturally occurring ECM, where in the ECM is right and hardened.
- It is known to use materials such as catgut and SIS to make appliances. See WO 95/06439 to Bolesky. The Bolesky application discloses devices that are semi-rigid and are formed into desired shapes, but Bolesky does not disclose a process for fabricating naturally occurring extracellular matrix parts that are rigid and hardened.
- In the present invention, the density and porosity of the extracellular matrix material can be controlled with drying protocols, including air drying, air drying with heat, and air drying with pressure. Thus, the ECM material can be dried to have a hardness sufficient to machine the device, without the need to form the device into the general shape by molding. By managing density and porosity of the ECM, various fixation devices can be made having superior material properties, wherein the devices promote healing while remaining biocompatable and biodegradable.
- The present invention, in one of its embodiments, is an orthopedic device for attaching soft tissue such as cartilage, ligaments, and tendons to bone. The device, which in one embodiment has a head end portion configured to engage soft tissue and a body portion configured to engage and attach to the bone, is preferably monolithic and formed as a unitary structure from naturally occurring extracellular matrix. The body portion of the device may illustratively terminate with a pointed end distal from the head portion to facilitate the penetration into the bone. Between the pointed distal end and the head portion, the device may illustratively be formed with radially outwardly extending barbs. These barbs may incline toward the head portion to provide a barbed tack or tack-like device. In some embodiments, a body portion is provided with diametrically opposed flats extending therealong, the flats being generally parallel.
- It has been found that a mass of naturally occurring ECM may be cured to be very rigid and hardened so that it can be machined using conventional cutting tools and using laser machining. The devices of this invention may be formed by machining a mass of cured matrix to define the head portion and body portion. The mass may be formed by compressing the ECM into a solid mass. For example, the ECM may be comminuted and formed into a solid mass with interlocking strands of ECM.
- For example, a tightly balled or compacted mass of pieces of SIS, illustratively comminuted SIS, can be formed by air drying or by hot air drying to become extremely hard. Unexpectedly, this hardened SIS can be machined or formed to have very sharp pointed ends, sharp barbs, etc. With this process, tacks, barbed tacks, and threaded elements may be machined from such cured mass of SIS. The tacks may be double-ended tacks or may include a central head portion and a sharpened body portion extending axially from each end of the head portion. Alternatively, a device may be made such that one body portion may be threaded while another body portion has barbs.
- In one embodiment, such tacks or barbs may be attached to devices made of naturally occurring extracellular matrix laminated together to form a body portion. For example, such a body portion may be fabricated to be placed into the tear of a meniscus to extend along the tear. One or more tacks or barbs made in accordance with the present invention may be coupled to the body portion to secure the device in the tear. Each of these tacks may be made from naturally occurring extracellular matrix cured to be hard and rigid.
- A staple or a staple-like device may be fabricated in accordance with the present invention utilizing two or more spaced apart barbs, each having a sharpened distal end and a proximal end. A connecting member may be placed between the proximal ends of the barbs. This connecting member may itself be made from a material such as SIS and optionally may be formed integrally with the barbs. Thus, in accordance with the present invention, an orthopedic staple device may be made from naturally occurring extracellular matrix hardened to have two or more sharpened barbs connected by strands of extracellular matrix such as SIS. In some embodiments of the present invention, such a staple or staple-like device may be made by laminating several layers of naturally occurring extracellular matrix and curing the layers to form a rigid and hardened sheet-like body. The barbs and the connecting member or members are then cut from the body. It has been found that the barbs and connecting member may be cut by laser machining a pattern on the sheet-like body. It has also been found that such barbs may be formed to have edges fused together by the laser machining process.
- In another embodiment, a device for anchoring a bone plug in an opening formed in a bone is provided. The device comprises a mass of naturally occurring extracellular matrix formed into a rigid and hardened member configured to be wedged in the opening between the bone plug and the bone. This rigid and hardened member may be formed with outwardly extending barbs to dig into the bone plug and the bone. The device may also have a connecting portion to extend into an opening in the bone plug. In some embodiments, the member is designed to extend axially along side the bone plug, and the member may have a plurality of radially outwardly and longitudinally extending fins to dig into the bone plug and the bone. The elongated member may be cannulated so that it may be guided into place on a guide member such as a K-wire. In some embodiments, the member may be formed in the shape of a screw to be threaded into the opening between the bone plug and the bone.
- There is provided, therefore, a method for anchoring a bone plug into an opening formed in a bone for receiving a plug, the method comprising the steps of providing a member formed into a rigid and hardened mass of naturally occurring extracellular matrix and placing the member into the opening between the bone and the bone plug. In some embodiments, the bone opening will be formed with a cylindrical wall and a bottom (or upper end) to receive a cylindrical bone plug, and the placing step will comprise placing the member in the bone plug to engage the bone plug and the bone. The member may be a double-ended tack, one end of which extends into the bottom of the opening and the other end of which extends into the bone plug. The double ended tack may radially expand the plug to engage the wall of the opening.
- In another embodiment, a device for attaching a soft tissue such as a tendon, ligament, or ligament replacement has been provided. The device, which is formed from a hardened mass of naturally occurring extracellular matrix, is provided with an elongated body to be received in the opening in the bone. The body has a channel therein for receiving a portion of the soft tissue. This body is configured to collapse inwardly to grip and hold the soft tissue in the channel when the body is inserted into the opening. In some embodiments, the body may be threaded to accomplish inserting the device into the opening. It will be appreciated that such a device may be used for attaching an ACL replacement ligament in a tunnel formed in a femur, wherein the tunnel has an axis and a generally cylindrical wall. Such tunnel formation is known in the ACL replacement art. The body may be provided with a generally axial channel for receiving a portion of the ligament replacement to be attached to the femur, and the body may be formed to collapse inwardly to secure the replacement ligament portion in the channel as the device is threaded in the femur tunnel.
- It will be appreciated that, in some embodiments, the naturally occurring extracellular matrix may be cured in such a fashion that the device will provide support structure members for various applications in the orthopedic field. For example, a device for regenerating a meniscus or a portion thereof may be provided with upper and lower panels and a support structure disposed between the upper and lower panels. This support structure may be provided by one or more members of rigid and hardened naturally occurring extracellular matrix. The one or more members may comprise a plurality of generally wedge-shaped members, each member having an upper edge supporting the upper panel and a lower edge supported on the lower panel. In other embodiments, the one or more support members may comprise a lattice of interlocking members, some of which extend radially toward the center of the knee and others of which extend transversely to the radially extending members. These members arranged in the lattice structure define a plurality of spaces between the upper and lower panel. These spaces may be filled with a biological material to promote regeneration of the meniscus. For example, the spaces may be filled with comminuted SIS, a bioactive agent, a biologically-derived agent, cells, a biological lubricant, a biocompatible polymer, a biocompatible inorganic material, or combinations thereof. The ECM support structure is believed to provide a framework for meniscus generation. The insertion of the device into a space from which the defective portion of the meniscus has been removed and the attachment of the device to the surrounding tissue places the device such that the meniscus will be regenerated in the space from which the defective portion has been removed. The structural members provided by the rigid and hardened ECM will provide the required support for the joint while regeneration occurs. See U.S. Provisional Patent Application No. 60/305,786, and U.S. Patent Application Serial No. ______ entitled “Meniscus Regeneration Device and Method” (Attorney Docket No. 265280-71141, DEP-745), filed concurrently herewith, each hereby incorporated by reference.
- Thus, one aspect of this disclosure is an orthopedic device for attaching soft tissue such as cartilage, ligament and tendons to bone, the device having a head portion configured to engage soft tissue and a body portion configured to engage and attach to the bone, the head portion and body portion being monolithic and formed from naturally occurring extracellular matrix (ECM) cured to be rigid and hardened to facilitate attachment to the bone.
- Another aspect of this disclosure is an orthopedic tack comprising a head portion and a first body portion formed from naturally occurring extracellular matrix cured to be hard and rigid.
- Yet another aspect of this disclosure is a device for repairing a tear in a cartilaginous surface such as a meniscus, the device comprising strips of naturally occurring extracellular matrix laminated together to form a body portion to be placed down into the tear to extend along the tear, and one or more tacks coupled to the body portion to secure it in the tear, each of the one or more tacks being formed from naturally occurring extracellular matrix.
- Still another aspect of this disclosure is an orthopedic device for attaching or repairing tissue, the device comprising two spaced apart barbs, each barb having a sharpened distal end and a proximal end, and a member connecting the proximal ends of the barbs, the barbs being formed from naturally occurring extracellular matrix
- An additional aspect of this disclosure is a device for anchoring a bone plug in an opening formed in a bone, the device comprising a mass of naturally occurring extracellular matrix formed into a rigid and hardened member configured to be wedged in the opening between the bone plug and the bone.
- Another additional aspect of this disclosure is a method for anchoring a bone plug into an opening formed in a bone for receiving the plug, the method comprising the steps of: providing a member formed into a rigid and hardened mass of naturally occurring extracellular matrix, and placing the member into the opening between the bone plug and the bone.
- Still another aspect of this disclosure is a device for attaching a soft tissue to a bone that has been prepared with an opening to receive the device, the device being formed from a hardened mass of naturally occurring extracellular matrix to form an elongated body to be received in the opening, the body having a channel therein for receiving a portion of the soft tissue, the body being configured to collapse inwardly to grip and hold the soft tissue portion in the channel when the body is inserted into the opening.
- A further aspect of this disclosure is a tack for driving into a bone, the tack having a proximal head end portion, a distal pointed end portion, and an intermediate body portion, the tack being formed from a hardened mass of naturally occurring extracellular matrix.
- In yet another aspect of this disclosure a device is provided for regenerating a meniscus or a portion thereof, the device comprising a wedge-shaped body having an upper panel and a lower panel angularly separated to define an apex portion and a base portion, the panels being formed of a naturally occurring extracellular matrix, and a support structure disposed between the upper panel and lower panel, the support structure comprising one or more members of rigid and hardened naturally occurring extracellular matrix.
- One more aspect of this disclosure is an orthopedic device comprising a mass of naturally occurring extracellular matrix or naturally occurring bioremodelable collageneous tissue matrix having a hardness greater than 30 HRD on the Rockwell D Scale.
- A final aspect of this disclosure is a composite orthopedic device comprising two connected portions, each portion comprising naturally occurring extracellular matrix material or naturally occurring bioremodelable collageneous tissue matrix, each portion having a hardness and a density, wherein one portion is configured for anchoring the device to native tissue and has a hardness of no less than 50 HRD on the Rockwell D Scale and a density greater than 0.5 g/cc, and the other portion has a different configuration, a different hardness and a different density.
- FIG. 1 is a perspective view of an orthopedic device for attaching soft tissue such as cartilage, ligaments and tendons to bone, the device having a head portion configured to engage the soft tissue and a body portion configured to engage and attach to the bone;
- FIG. 2 is a side view of the device of FIG. 1;
- FIG. 3 is an end view of the device looking along the lines3-3 in FIG. 2;
- FIG. 4 is a side view of a device similar to the FIG. 1 device except that it is elongated;
- FIG. 5 is a side view of the double-ended tack device;
- FIG. 6 is a side view of a double-ended device, one end configured as a tack with barbs and the other end being threaded;
- FIG. 7 is an end view of the device shown in FIG. 6 looking along the lines7-7;
- FIG. 8 is a side view of an elongated tack-like device;
- FIG. 9 is a side view of a tack-like device used to hold tissue in an opening formed in a bone;
- FIG. 10 is a partially sectioned side view of a tack-like device with a central core filled with comminuted ECM material;
- FIG. 11 is a side view of a tack-like device with a design somewhat different from the FIG. 1 design;
- FIG. 12 is an end view of the FIG. 11 device looking along the lines12-12 in FIG. 11.
- FIG. 13 is a perspective view of a device configured to collapse on soft tissue as the device is inserted into an opening in a bone;
- FIG. 14 shows the device of FIG. 13 inserting soft tissue into bone.
- FIG. 15 is a top view of the FIG. 16 device looking along the lines1515 in FIG. 16.
- FIG. 16 is similar to the FIG. 13 device with helical thread segments to facilitate threading the device into an opening in a bone;
- FIG. 17 is a diagrammatical drawing showing how the device of FIG. 6 may be threaded into a bone plug and then how the bone plug may be inserted into the opening in a bone;
- FIG. 18 is a sectional view showing the bone plug of FIG. 17 installed in the bone with the double-ended device of FIG. 6;
- FIG. 19 shows a double-ended tack made in accordance with the present invention used to insert and hold a bone plug into an opening;
- FIG. 20 shows a sectional view of the bone plug of FIG. 19 after insertion;
- FIG. 21 shows an elongated and cannulated device which has a generally triangular cross-section with relatively sharp side edges to be driven between a bone plug and an opening in which the plug is inserted.
- FIG. 22 is a perspective view of a device similar to the FIG. 21 device except that it has a generally square cross-section with four relatively sharp side edges;
- FIG. 23 shows a perspective view of how the devices of FIGS. 21 and 22 may be driven to wedge between a bone plug and a bone opening to anchor the bone plug;
- FIG. 24 shows a device using barbs made in accordance with the present invention to hold a bone plug into an opening formed in the bone;
- FIG. 25 shows an end view of the bone plug of FIG. 24 inserted into the bone opening;
- FIG. 26 shows a staple-like device made in accordance with the present invention.
- FIG. 27 shows a variation on the staple-like device of FIG. 26;
- FIG. 28 shows how a staple-like device may be cut from laminated layers of ECM material;
- FIG. 29 shows a laminated body of ECM material held in position by tack-like devices;
- FIG. 29(a) shows the device of FIG. 29 without a connecting member between the tacks;
- FIG. 30 shows a perspective view of staple-like devices shown in FIGS. 26 and 27 used to hold a sheet-like body of ECM material in a tear in a meniscus;
- FIG. 31 shows a three-barbed staple device which may be cut from laminated layers of ECM material to have a desired pattern; and
- FIG. 32 shows a device similar to FIG. 31, but having a different pattern.
- FIGS.1-3 show an
orthopedic device 10 for attaching soft tissue such as cartilage, ligaments, tendons to bone, the device having ahead portion 12 configured to engage soft tissue and abody portion 14 configured to engage and attach to the bone. Thehead portion 12 andbody portion 14 are illustratively monolithic and formed from naturally occurring extracellular matrix cured to be rigid and hardened to facilitate attachment to the bone. Thebody portion 14 terminates with apointed end 16 distal from thehead portion 12 to facilitate penetration into the bone. It will be appreciated that the ECM material from which thedevice 10 is fabricated will be cured to be hardened and toughened such that thedevice 10 may be driven into bone tissue. Thepointed end 16 with its hardness and toughness will facilitate insertion into the bone. To enhance the holding or gripping ability of thedevice 10, thebody portion 14, between thepointed end 16 and thehead portion 12, is provided with radially outwardly extending barbs orbarb portions portions opposed flats body portion 14, the flats being generally parallel. As best seen in FIG. 3,flats 24 are formed on diametrically opposite sides of thebarb portion 20 while theflats 26 are formed on the diametrically opposite sides of thebarb portion 22. - The device of FIGS.1-3 and other similar devices disclosed herein may be fabricated by compacting comminuted or shredded naturally occurring ECM material into bar or rod stock by curing the material such that it is very rigid and hardened. The curing may be accomplished by air drying comminuted ECM at room temperature for several days. Comminuted ECM, when dried at room temperature for several days, becomes very tough and hard and can be machined using conventional tools. In one example, a sample of 3 cc of comminuted SIS that has been air dried at room temperature for several days produced a piece of SIS stock that is 7-8 mm in diameter and 2 mm thick, and has a hardness of about 70 HRD on the “Rockwell D” scale. For comparison, polyethylene tests at about 30 HRD, and plexiglass is between 70 and 75 HRD on the “Rockwell D” scale (ASTM D2240, Vol. 0991). Testing was done using an e2000 series durometer from PTC Instruments (model 502D). This durometer conforms to the ASTM D2240 type D standard. The indentor in this type (as in all durometers conforming to ASTM D2240 type D) is a sharp point indentor with a 30 degree included angle and applies a force of 4536 gmf on the sample being tested.
- Thus, in an illustrated embodiment an orthopaedic device is formed from comminuted SIS that has been air dried at room temperature for several days. The SIS has a hardness of at least 30 HRD on the “D” scale, particularly at least 50 on the “D” scale, more particularly above 60 HRD on the “D” scale, and most particularly about 70 HRD or above on the “D” scale. A hardness of 60-70 is usable in many applications.
- One sample of comminuted and air-dried SIS was found to have a density of 0.747+/−0.059 gm/cc. For comparison, the density of the commercially available RESTORE® product, an ECM laminate, is 0.466+/−0.074 gm/cc. And, an ECM product consisting of toughened SIS laminate as described in “Meniscus Regeneration Device and Method” (provisional U.S. Patent Application No. 60/305,786 filed on Jul. 16, 2001, and U.S. Patent Application Serial No. ______ entitled “Meniscus Regeneration Device and Method” (Attorney Docket No. 265280-71141, DEP-745), filed concurrently herewith, has been made with a density of 0.933+/−0.061 gm/cc; and an SIS foam can be made as described in U.S. Patent Application Serial No. ______ entitled “Cartilage Repair and Regeneration Device and Method” (Attorney Docket No. 265280-71145, DEP-752), filed concurrently herewith and hereby incorporated by reference, with a substantially lower density: 0.091+/−0.019 gm/cm3; 0.035+/−0.012 gm/cm3; or 0.006+/−0.002 gm/cm3, for example.
- Drying and hardening may be accelerated by using heat and/or pressure. In an illustrated embodiment, the ECM may be comminuted using a COMITROL machine from Urschel Laboratories (Valparaiso, Ind.), with a Vericut sealed impeller at 9391 rpm.
- Once the bar stock or rod stock is provided, it may be machined with conventional machine shop equipment to the desired shapes. For example, the
device 10 may be turned on a lathe or similar equipment to produce thehead portion 12 and thebody portion 14 with its generallyconical barb portions flats conical portions device 10, for example, by cutting longitudinally extending slots in thebody portion 14 to provide more radially outwardly barbs inclined axially toward thehead portion 12. - It has been found that tacks or tack-like devices may be made as shown in FIGS.1-3 such that they can be driven into bone tissue to be securely anchored in the tissue. The
head portion 12 ofsuch devices 10 may trap soft tissue against the bone surface. It will be appreciated that thehead portion 12 may have a larger diameter than proportionately shown in FIGS. 1-3 and that thehead portion 12 may have a shape other than the circular shape depicted in FIGS. 1-3. Thehead portion 12 itself may be provided with a roughened or barbedsurface facing end 16 to attach to the soft tissue being anchored. It will be appreciated that a plurality ofdevices 10 may be used to secure soft tissue to bone. - FIG. 4 shows a
device 30, similar to thedevice 10 of FIGS. 1-3 except that thedevice 30 is longer. Throughout this description, some corresponding portions of various devices will be identified with the same reference numerals. For example, thedevice 30 in FIG. 4 has ahead portion 12, abody portion 14, and a pointeddistal end 16. Thedevice 30 has three barb portions and three sets of flats. Thedevice 30, of course, is to be driven further into the bone structure than thedevice 10. - FIG. 5 shows a
device 36 which is essentially a double-ended tack, each end of which is similar to thedevice 10 with acommon head portion 12, having an illustrative proportionately larger diameter than thehead portion 12 of FIGS. 1-3. Thedevice 36 of FIG. 5 is provided so that one of itsbody portions 14 may be inserted into one bone or tissue structure while theother body portion 14 may be inserted into another bone or tissue structure. The diameter of thehead portion 12 of thedevice 36 may be made smaller or larger depending on the attachment application. - FIG. 6 shows a
device 40 which is a double-ended device similar todevice 36 of FIG. 5 except that onebody portion 42 is threaded. Illustratively, thedevice 40 has anotherbody portion 14 similar to thebody portion 14 of FIGS. 1-3, with a threadedopposite end portion 42. Thehead portion 44 of thedevice 40 may be hexagonal as illustrated or otherwise formed to provide a drive portion for inserting the device. It will be appreciated that a surgeon will be provided with a tubular socket to receive and drivingly engage thehead portion 44. Theillustrative device 40, which may be cannulated as indicated atbroken lines 46 so that thedevice 40 may be accurately positioned on a K-wire, may optionally have its threaded end provided with diametrically opposed flats 48 (FIG. 7). Theseflats 48 serve to impede rotation subsequent to implantation. - One use of the
device 40 shown in FIGS. 6 and 7 will be discussed in conjunction with inserting bone plugs in connection with FIGS. 17 and 18. - FIG. 8 shows a
tack 60 with ahead portion 62 and anelongated body portion 64 having adistal end 66 that is somewhat sharpened to a point. Thetack 60 in FIG. 8 is provided with a pair of longitudinally spaced apart,circumferential ridges 68 between thedistal end 66 and thehead portion 62. Thesecircumferential ridges 68 serve to lock the device into the surrounding native tissue (i.e. bone). - A
device 70 shown in FIG. 10 is similar todevices proximal body portion 72 including thehead 74 is formed with a central bore or opening 76 which may be filled with a mass of comminuted naturally occurring ECM. Thiscentral bore space 76 in thedevice 70 is therefore filled with a biological material to provide a framework for more rapid resorption. - A
device 80 is shown in FIGS. 11 and 12 to have ahead portion 82, abody portion 84 with a distal sharpenedend 85. It will be appreciated that thedevice 80 is similar to the prior devices except thatbody portion 84 is formed to have three angularly spaced rows ofbarbs 86 formed at least in part by three angularly spaced apart, longitudinally extendinggrooves 88 best seen in FIG. 12. It will be appreciated that thebarbs 86 are formed to extend radially outwardly from thebody portion 84 and inclined axially toward thehead portion 82. Thesebarbs 86 and thebarbs devices head portion 82 is shown having three angularly spacednotches 90, which are provided to aid in grasping in delivery of the device. Other configurations are within the scope of this invention. - In accordance with the present invention, a tack or tack-like device may be provided as shown in FIG. 9 without a head portion. FIG. 9 illustrates a
device 96, which may be cannulated as indicated atbroken lines 98, for insertion in the bone to hold soft tissue. As withdevices device 96 is provided with a plurality ofbarbs - The designs shown in FIGS.1-9, therefore, provide an orthopaedic tack or barbed tack fabricated from naturally occurring ECM that has been cured to be hard and rigid. These
devices - A device110 is provided for attaching a soft tissue such as a ligament or a tendon to a bone is shown in FIGS. 13-15, the device being formed from a hardened mass of naturally occurring ECM to have an elongated body to be received in an opening formed in the bone. The device 110 has a
head portion 112, acentral body portion 114 and adistal end 116 all shaped and configured for insertion into a bone opening having a diameter smaller than the largest diameter of thecentral body portion 114. The device 110 is also provided with a central, longitudinal extendingchannel 118 extending axially through the device. The illustrative device 110 is further formed with axially and radially extending cut-out or slot 120 which opens from thechannel 118 to the exterior of the device 110. It will be appreciated that a piece of soft tissue which may be a ligament, a tendon, or a ligament graft such as an ACL graft, may be inserted axially into thechannel 118 to be carried with the device 110 into the bone. While the device 110 is formed from a hardened mass of naturally occurring ECM, it is configured for being forced into an opening prepared in a bone, and to collapse inwardly to grip thesoft tissue 122 in thechannel 118. The interior of thechannel 118 may be provided with a roughened texture or even interior barbs or gripping surfaces to grip thesoft tissue 122 more securely as the device 110 collapses radially inwardly.Central body portion 114 is provided with three radially outwardly extendingfrustcoconical engagers 124 which serve to anchor the device 110 in the bone. Theseengagers 124 have outer surfaces which incline axially toward thehead portion 112 and radially outwardly. As the device 110 is driven into the bone opening, theseengagers 124 will cause the device to collapse inwardly by bringing the longitudinal walls of the cut-out 120 closer together, reducing the diameter of thechannel 118, and holdingsoft tissue 122 securely withinbone 128, as shown in FIG. 14. Theengagers 124, as illustrated in FIG. 13, have abrupt radially outwardly extending and axially facing surfaces for anchoring the device 110 in the bone opening. - It will be appreciated that the
device 130 may be formed as a threaded device as shown in FIGS. 15-16 with helical thread segments replacing theengagers 144 on thecentral body portion 134. When thedevice 130 is so threaded, and thehead end portion 132 with the hex-shapedcuts 146 is engaged with a socket driver, with the driver end preferably formed on a tube for receiving thesoft tissue graft 142, thedevice 130 can be threaded into a bone opening. - FIGS. 17 and 18 show diagrammatically how the
device 40 of FIGS. 6 and 7 can be used to anchor abone plug 150 into anopening 152 drilled or otherwise formed in a bone. The threadedbody portion 42 of thedevice 40 may be threaded into a central opening in thebone plug 150 as depicted in FIGS. 17 and 18. Theopening 152 in the bone may be provided at a diameter which will snugly receive thebone plug 150. The barbed portion (body portion 14) ofdevice 40 is provided to anchor into the bottom of theopening 152. It may be advantageous to provide acentral pilot hole 154 in the bottom of theopening 152 to receive and guide thebody portion 14 of thedevice 40. When thebone plug 150 is forced into theopening 152, the structure shown in FIG. 18 will result with thedevice 40 anchoring thebone plug 150 in the bone. - It is contemplated that the method and device in FIGS. 17 and 18 may be used to anchor a
cartilage plug 156 into a bone. Essentially, a defect in the cartilage in the surface of a bone, such as on the condyle of a knee, will be removed by forming theopening 152 for receiving thebone plug 150. Acartilage graft 156 will be secured to thebone plug 150 to be used to close theopening 158 made in thecartilage layer 160 in the bone. Thus, thebone plug 150 and theanchoring device 140 may be used to hold acartilage plug 156 in position in anopening 158 incartilage 160 such thatcartilage plug 156 lies in an essentially contiguous plane with the undamaged surroundingcartilage 168. - FIGS. 19 and 20 show how a
bone plug 170, which is illustratively formed as a cylindrical bone plug to be anchored into acylindrical opening 172 in a bone, may be used with thedevice 36 shown in FIG. 5. Thebone opening 172 is provided with a depth sufficient to receive aplug 170, and thebottom 175 of theopening 172 is provided with apilot hole 174. Theplug 170 is prepared with a split end as indicated at 176 and acentral pilot opening 178 atbottom surface 179, for facingbottom 175 ofopening 172. It will be appreciated that thissplit end 176 of thebone plug 170 will be wedged outwardly by thedevice 36 so that the outer surface of thebone plug 170 will firmly engage the internal cylindrical surface of thebone opening 172. FIG. 20 shows thedevice 36 with one of itsend portions 14 anchored into the bone in the bottom of theopening 172. - FIGS. 21 and 22
show devices devices device 180 is elongated on a central axis indicated at 182 and may be cannulated on the axis as indicated at 184. Thus, thedevice 180 may be slid onto a K-wire and located accurately between the outer wall of a bone plug and the inner wall of an opening in which the bone plug is to be anchored. Theillustrative device 180 has a generally triangular cross-section providing three longitudinally extending sharpenededges 183 for cutting into the exterior of the bone plug and the interior of the bone opening. Thus, thedevice 180 may be forced into the space between the exterior of the bone plug and the wall of the opening to extend along the bone plug and wedge the bone plug into firm engagement with the bone opening. Thedevice 190, which is formed about theaxis 192 and which may also be cannulated as indicated at 194, is formed to be have a generally square cross-section providing four longitudinally extendingside edges 193 to cut into the exterior of the bone plug and the interior of the bone opening. - In orthopedic surgery work, there are various reasons to insert a bone plug into an opening formed in a bone. While circular bone plugs and circular bone openings are illustrated and discussed herein, it will be appreciated that bone plugs may take various cross-sectional shapes determined by the instruments used to cut the plugs and the particular surgical need. Typically, it is more convenient to drill a cylindrical opening into a bone for receiving a bone plug. To have the bone plug anchored and secured to the wall of the bone opening, it is often necessary to force the bone plug against the wall of the opening in the host bone so that the required bone nourishment and eventual bone ingrowth may take place. This aspect of anchoring bone plugs to bone openings is well known in the orthopedic field. For example, in ACL surgery, it is known to anchor a bone plug harvested on the end of a patellar tendon strip in a tunnel formed upwardly into the femur. Essentially, the patellar tendon is harvested with a bone plug on one end of the strip. The other end may be provided with a bone plug as well. This patellar strip is then used as an ACL graft replacement. A tunnel is formed upwardly through a tibial platform into the femur and the ACL graft is secured in place by anchoring one of the bone plugs in the femur and the other of the bone plugs in the tibia. Conventionally, cannulated screws are threaded into the openings to extend alongside the bone plugs. These screws thread into the bone plugs and into the walls of the tunnels to push the plugs into engagement with the tunnel walls. The
devices bone plug 200 is illustrated inserted into the opening ortunnel 202. Again, while theplug 200 is illustrated as having a cylindrical cross-section, it will be appreciated that theplug 200 will have a cross-sectional shape defined by the cutting tools used to remove theplug 200 from its original position. Thedevice 190, however, will be inserted into the space between theplug 200 and the wall of theopening 202 to force the plug against the wall of the opening. It is understood that FIG. 23 shows only a portion of a ACL graft attached to theplug 200. - Referring to FIGS. 24 and 25, it will be seen that a
bone plug 210 may be secured in atunnel 212 bybarbed anchors 214. Each of thesebarbed anchors 214 may be formed from hardened naturally occurring ECM to havesharp barbs connector portion 220 having aright angle extension 220 to be received into anopening 222 in thebone plug 210. Thus, thebarbed anchors 214 may be attached to thebone plug 210 to extend along side the bone plug as it is inserted into thetunnel 212. An ACL graft may be attached to thebone plug 210 as indicated at 224. - The devices are made from ECM that has been cured to a hardness to allow machining. Each of these devices retains its structural integrity for a sufficient period of time to allow the intended orthopaedic fixation, and to permit bone or cartilage ingrowth or repair to begin. Preferably, the devices such as
devices devices - Referring to FIG. 26, it will be seen that an
orthopedic device 240 for attaching or repairing tissue is illustrated, thedevice 240 comprising two spaced apartbarb portions proximal end portion 246, a sharpeneddistal end portion 248, and at least onebarb 243. Thedevice 240 has a connectingmember 250 extending between the proximal ends 246 to provide a staple-like device. Each of thebarb portions entire device 240 may be machined from a single block of hardened ECM. Alternatively,barb portions member 250 may be machined separately, and the connectingmember 250 may have its ends inserted into and joined into theproximal end portions 246 of the barb portions as indicated at 252. Connectingmember 250 may be affixed to thebarb portions insertion 252. Thedevice 240, therefore, may be used as a staple, for example, with thebarb portions member 250 holding tissue to the bone. The connectingmember 250 may be formed from hardened naturally occurring ECM, flexible ECM, or another material. - FIG. 27 shows a
device 260 with similar spaced apartbarb portions member 262 which is hollow and filled with comminuted SIS. - FIG. 28 shows an approach for making a staple or staple-
like device 270 having spaced apartbarb portions member 276. Thedevice 270 contemplates that a plurality of layers of naturally occurring ECM material will be laminated together to be cured by air drying to form a rigid and hardened plate-like body. Then, alaser machine unit 278 will be programmed to cut a pattern which will produce adevice 270 from the laminated layers of ECM. It has been found that such laser cutting of several layers of ECM will producebarb portions barbs 273.Device 270 may optionally have a plurality of laser cut holes 275, which further fuse together the layers of ECM. - FIGS. 31 and 32
show devices device 280 is shown having three spaced apartbarb portions member 288 extending between the proximal ends of the barb portions. Thedevice 290 in FIG. 32 is shown as having three spaced apartbarb portions member 298 connecting the proximal ends of the barbs. Illustratively, thebarb portions member 288 may all lie in a common plane. Alternatively, the connectingmember 288 may be warped or curved so that thebarb portions device 290, thebarb portions member 298 may be manipulated by the surgeon to relocate the direction of thebarb portions - FIG. 29 shows the staple-
like device 310 comprising a pair of spaced apartbarb portions barb portions member 316 extending between the proximal ends of the barb portions. Thedevice 310 comprises strips of naturally occurring ECM laminated together to form abody portion 320 to be placed down into a tear in a cartilaginous surface such as a meniscus. Thebarbs 313 hold thebody 320 in the tear. It is contemplated that the ends of thebody 320 will be attached securely to thebarb portions body 320 tobarb portions body 320 into slots provided inbody portions body 320. It is contemplated that, once thedevice 310 is fully inserted in the meniscus tear and attached with thebarb portions member 316 and the upper ends of the barb portions may be cut away leaving a structure such as that shown in FIG. 29(a). Thebody portion 320 may have characteristics different from those of thebarb portions body portion 320 may have a greater porosity or lower density or lower hardness than the barb portions, and may have characteristics similar to those of commercial products like the RESTORE patch, for example. It should be understood that these possible differences in characteristics are provided by way of example only; the illustrated embodiments are not intended to limit the material for thebody portion 320. - FIG. 30 shows a
device 340 comprising a body such as thebody 320 made from laminating layers of naturally occurring ECM together. The ends of thebody 320 in thedevice 340 are attached to the connectingmembers 250 similar to twodevices - It is anticipated that the hardened ECM devices of the present invention can be combined with one or more bioactive agents (in addition to those already present in naturally occurring ECM), one or more biologically-derived agents or substances, one or more cell types, one or more biological lubricants, one or more biocompatible inorganic materials, one or more biocompatible synthetic polymers and one or more biopolymers. Moreover, the hardened ECM devices of the present invention can be combined with devices containing such materials.
- “Bioactive agents” include one or more of the following: chemotactic agents; therapeutic agents (e.g. antibiotics, steroidal and non-steroidal analgesics and anti-inflammatories, anti-rejection agents such as immunosuppressants and anticancer drugs); various proteins (e.g. short chain peptides, bone morphogenic proteins, glycoprotein and lipoprotein); cell attachment mediators; biologically active ligands; integrin binding sequence; ligands; various growth and/or differentiation agents (e.g. epidermal growth factor, IGF-I, IGF-II, TGF-β I-III, growth and differentiation factors, vascular endothelial growth factors, fibroblast growth factors, platelet derived growth factors, insulin derived growth factor and transforming growth factors, parathyroid hormone, parathyroid hormone related peptide, bFGF; TGFβ superfamily factors; BMP-2; BMP-4; BMP-6; BMP-12; sonic hedgehog; GDF5; GDF6; GDF8; PDGF); small molecules that affect the upregulation of specific growth factors; tenascin-C; hyaluronic acid; chondroitin sulfate; fibronectin; decorin; thromboelastin; thrombin-derived peptides; heparin-binding domains; heparin; heparan sulfate; DNA fragments and DNA plasmids. If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the present invention, and such substances should be included in the meaning of “bioactive agent” and “bioactive agents” unless expressly limited otherwise.
- “Biologically derived agents” include one or more of the following: bone (autograft, allograft, and xenograft) and derivates of bone; cartilage (autograft, allograft, and xenograft), including, for example, meniscal tissue, and derivatives; ligament (autograft, allograft, and xenograft) and derivatives; derivatives of intestinal tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of stomach tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of bladder tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of alimentary tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of respiratory tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of genital tissue (autograft, allograft, and xenograft), including for example submucosa; derivatives of liver tissue (autograft, allograft, and xenograft), including for example liver basement membrane; derivatives of skin tissue; platelet rich plasma (PRP), platelet poor plasma, bone marrow aspirate, demineralized bone matrix, insulin derived growth factor, whole blood, fibrin and blood clot. Purified ECM and other collagen sources are also intended to be included within “biologically derived agents.” If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the present invention, and such substances should be included in the meaning of “biologically-derived agent” and “biologically-derived agents” unless expressly limited otherwise.
- “Biologically derived agents” also include bioremodelable collageneous tissue matrices. The expressions “bioremodelable collagenous tissue matrix” and “naturally occurring bioremodelable collageneous tissue matrix” include matrices derived from native tissue selected from the group consisting of skin, artery, vein, pericardium, heart valve, dura mater, ligament, bone, cartilage, bladder, liver, stomach, fascia and intestine, tendon, whatever the source. Although “naturally occurring bioremodelable collageneous tissue matrix” is intended to refer to matrix material that has been cleaned, processed, sterilized, and optionally crosslinked, it is not within the definition of a naturally occurring bioremodelable collageneous tissue matrix to purify the natural fibers and reform a matrix material from purified natural fibers. The term “bioremodelable collageneous tissue matrices” includes “extracellular matrices” within its definition.
- “Cells” include one or more of the following: chondrocytes; fibrochondrocytes; osteocytes; osteoblasts; osteoclasts; synoviocytes; bone marrow cells; mesenchymal cells; stromal cells; stem cells; embryonic stem cells; precursor cells derived from adipose tissue; peripheral blood progenitor cells; stem cells isolated from adult tissue; genetically transformed cells; a combination of chondrocytes and other cells; a combination of osteocytes and other cells; a combination of synoviocytes and other cells; a combination of bone marrow cells and other cells; a combination of mesenchymal cells and other cells; a combination of stromal cells and other cells; a combination of stem cells and other cells; a combination of embryonic stem cells and other cells; a combination of precursor cells isolated from adult tissue and other cells; a combination of peripheral blood progenitor cells and other cells; a combination of stem cells isolated from adult tissue and other cells; and a combination of genetically transformed cells and other cells. If other cells are found to have therapeutic value in the orthopaedic field, it is anticipated that at least some of these cells will have use in the present invention, and such cells should be included within the meaning of “cell” and “cells” unless expressly limited otherwise. Illustratively, in one example of embodiments that are to be seeded with living cells such as chondrocytes, a sterilized implant may be subsequently seeded with living cells and packaged in an appropriate medium for the cell type used. For example, a cell culture medium comprising Dulbecco's Modified Eagles Medium (DMEM) can be used with standard additives such as non-essential amino acids, glucose, ascorbic acid, sodium pyrovate, fungicides, antibiotics, etc., in concentrations deemed appropriate for cell type, shipping conditions, etc.
- “Biological lubricants” include: hyaluronic acid and its salts, such as sodium hyaluronate; glycosaminoglycans such as dermatan sulfate, heparan sulfate, chondroiton sulfate and keratan sulfate; synovial fluid and components of synovial fluid, including mucinous glycoproteins (e.g. lubricin), tribonectins, articular cartilage superficial zone proteins, surface-active phospholipids, lubricating glycoproteins I, II; vitronectin; and rooster comb hyaluronate. “Biological lubricant” is also intended to include commercial products such as ARTHREASE™ high molecular weight sodium hyaluronate, available in Europe from DePuy International, Ltd. of Leeds, England, and manufactured by Bio-Technology General (Israel) Ltd., of Rehovot, Israel; SYNVISC® Hylan G-F 20, manufactured by Biomatrix, Inc., of Ridgefield, N.J. and distributed by Wyeth-Ayerst Pharmaceuticals of Philadelphia, Pa.; HYLAGAN® sodium hyaluronate, available from Sanofi-Synthelabo, Inc., of New York, N.Y., manufactured by FIDIA S.p.A., of Padua, Italy; and HEALON® sodium hyaluronate, available from Pharmacia Corporation of Peapack, New Jersey in concentrations of 1%, 1.4% and 2.3% (for ophthalmologic uses). If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the present invention, and such substances should be included in the meaning of “biological lubricant” and “biological lubricants” unless expressly limited otherwise.
- “Biocompatible polymers” is intended to include both synthetic polymers and biopolymers (e.g. collagen). Examples of biocompatible polymers include: polyesters of [alpha]-hydroxycarboxylic acids, such as poly(L-lactide) (PLLA) and polyglycolide (PGA); poly-p-dioxanone (PDS); polycaprolactone (PCL); polyvinyl alcohol (PVA); polyethylene oxide (PEO); polymers disclosed in U.S. Pat. Nos. 6,333,029 and 6,355,699; and any other bioresorbable and biocompatible polymer, co-polymer or mixture of polymers or co-polymers that are utilized in the construction of prosthetic implants. In addition, as new biocompatible, bioresorbable materials are developed, it is expected that at least some of them will be useful materials from which the anchors may be made. It should be understood that the above materials are identified by way of example only, and the present invention is not limited to any particular material unless expressly called for in the claims.
- “Biocompatible inorganic materials” include materials such as hydroxyapatite, all calcium phosphates, alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium carbonate, barium carbonate, calcium sulfate, barium sulfate, polymorphs of calcium phosphate, sintered and non-sintered ceramic particles, and combinations of such materials. If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the present invention, and such substances should be included in the meaning of “biocompatible inorganic material” and “biocompatible inorganic materials” unless expressly limited otherwise.
- It is expected that various combinations of bioactive agents, biologically derived agents, cells, biological lubricants, biocompatible inorganic materials, biocompatible polymers can be used with the hardened ECM devices of the present invention.
- It is expected that standard disinfection (e.g. 0.15% peracetic acid in 20% ethanol) and sterilization techniques (e.g. electron beam or gamma irradiation) may be used with the products of the present invention. Although it is anticipated that some of the identified additives could be added to the devices prior to terminal sterilization, other additives, such as cells, for example, would be cultured on previously sterilized devices. In addition, some bioactive agents could be added to the devices in the operating room, such as an autograft of PRP for example.
- The hardened ECM devices of the present invention can also be combined with other devices that include naturally occurring ECM, and it is expected that the hardened ECM devices can be combined with purified ECM and commercially available collagen materials and/or with devices that contain purified ECM and commercially available collagen materials.
- Illustrative applications for the hardened ECM devices of the present invention, and potential materials to be incorporated with the hardened ECM devices of the present invention, are illustrated in the following U.S. Patent Applications, filed concurrently herewith and incorporated by reference herein in their entireties: Serial No. ______ entitled “Meniscus Regeneration Device and Method” (Attorney Docket No. 265280-71141, DEP-745); Serial No. ______ entitled “Cartilage Repair Apparatus and Method” (Attorney Docket No. 265280-71143, DEP-749); Serial No. ______ entitled “Unitary Surgical Device and Method” (Attorney Docket No. DEP-750); Serial No. ______ entitled “Hybrid Biologic/Synthetic Porous Extracellular Matrix Scaffolds” (Attorney Docket No. 265280-71144, DEP-751); Serial No. ______ entitled “Cartilage Repair and Regeneration Device and Method” (Attorney Docket No. 265280-71145, DEP-752); and Serial No. ______ entitled “Cartilage Repair and Regeneration Device and Method” (Attorney Docket No. 265280-71145, DEP-752). Thus, implants can be made as composites of materials of different characteristics.
- Although the invention has been described in detail with reference to certain preferred embodiments, variations and modifications exist within the scope and spirit of the invention as described and defined in the following claims.
Claims (106)
1. An orthopedic device for attaching soft tissue such as cartilage, ligament and tendons to bone, the device having a head portion configured to engage soft tissue and a body portion configured to engage and attach to the bone, the head portion and body portion being monolithic and formed from naturally occurring extracellular matrix (ECM) cured to be rigid and hardened to facilitate attachment to the bone.
2. The device of claim 1 in which the body portion terminates with a pointed end distal from the head portion to facilitate penetration into the bone.
3. The device of claim 2 in which the body portion between the pointed end and the head portion is formed with radially outwardly extending barbs.
4. The device of claim 3 in which the barbs are inclined toward the head portion.
5. The device of claim 4 in which the body portion is provided with diametrically opposed flats extending therealong, the flats being generally parallel.
6. The device of claim 5 in which the device is formed by machining a mass of the cured matrix to define the head portion and body portion.
7. The device of claim 1 in which the cured ECM is cured by air drying.
8. The device of claim 1 in which the cured ECM is dried at room temperature.
9. The device of claim 1 in which the cured ECM is dried with pressure.
10. The device of claim 1 in which the cured ECM is dried with heat.
11. The device of claim 10 in which the cured ECM is dried with pressure.
12. The device of claim 1 in which the cured ECM has a hardness of at least 30 on the “D” scale.
13. The device of claim 1 in which the cured ECM has a hardness of at least 60 on the “D” scale.
14. The device of claim 1 in which the cured ECM has a hardness of at least 70 on the “D” scale.
15. The device of claim 1 in which the body portion is formed with an outer shell defining a central core space, and comprising a biological material to provide a framework for tissue regeneration disposed in the space.
16. The device of claim 15 in which the biological material is comminuted naturally occurring ECM.
17. The device of claim 16 in which the cured ECM is SIS and the comminuted ECM is SIS.
18. The device of claim 1 in which the head portion and body portion are formed about a central axis and concentrically and axially cannulated to receive a guide member.
19. The device of claim 1 in which the head portion and body portion are formed about a central longitudinal axis and a second body portion is provided to extend axially away from the head portion in a direction opposite to the first mentioned body portion.
20. The device of claim 19 in which the second body portion is threaded.
21. The device of claim 20 in which the second body portion is provided with diametrically opposed, longitudinally extending generally parallel flats in the portion threaded.
22. The device of claim 21 in which the first mentioned body portion is provided with outwardly extending barbs.
23. The device of claim 22 in which the barbs extend radially outwardly and axially toward the head portion.
24. The device of claim 23 in which the first mentioned body portion terminates with a pointed end distal from the head portion.
25. A device for repairing a tear in a cartilaginous surface such as a meniscus, the device comprising strips of naturally occurring extracellular matrix laminated together to form a body portion to be placed down into the tear to extend along the tear, and one or more tacks coupled to the body portion to secure it in the tear, each of the one or more tacks being formed from naturally occurring extracellular matrix cured to be hard and rigid.
26. The device of claim 25 in which the body portion has an upper edge, a lower edge and opposite end edges, the one or more tacks comprising a tack coupled to each of the opposite end edges of the body portion.
27. The device of claim 26 in which each tack extends along the opposite end edge to which it is coupled.
28. The device of claim 27 in which the body portion is coupled to each tack along its length.
29. The device of claim 28 in which each tack is provided with barbs which extend radially outwardly and axially toward the upper edge.
30. The device of claim 25 comprising a member connecting the one or more tacks, the connecting member being formed from naturally occurring extracellular matrix.
31. The device of claim 30 in which the connecting member is detachable by a surgeon after the body portion and tacks are inserted into the tear.
32. The device of claim 25 in which the ECM is SIS.
33. The device of claim 32 in which the SIS is dried at room temperature.
34. The device of claim 32 in which the SIS has a hardness of at least 30 on the “D” scale.
35. The device of claim 32 in which the SIS has a hardness of at least 60 on the “D” scale.
36. The device of claim 32 in which the SIS has a hardness of at least 70 on the “D” scale.
37. The device of claim 25 in which the one or more tacks comprise a pair of tacks each having a pointed distal end and a proximal end and a connecting member coupled between the proximal ends of the tacks, the connecting member being coupled to the body portion.
38. The device of claim 37 in which the connecting member extends transverse to the body portion, the connecting member having a central portion coupled to the body portion.
39. An orthopedic device for attaching or repairing tissue, the device comprising two spaced apart barbs, each barb having a sharpened distal end and a proximal end, and a member connecting the proximal ends of the barbs, the barbs being formed from naturally occurring extracellular matrix.
40. The device of claim 39 in which the connecting member is formed of the naturally occurring extracellular matrix.
41. The device of claim 40 in which the matrix is SIS.
42. The device of claim 39 in which the connecting member and the barbs are formed from layers of naturally occurring extracellular matrix laminated together and cured to form a rigid and hardened sheet-like body, the barbs and the connecting member being cut from the body.
43. The device of claim 42 in which the barbs and connecting member are cut by laser machining a pattern on the sheet-like body.
44. The device of claim 43 in which the barbs have edges formed by fusing the layers together in the laser machining.
45. The device of claim 44 further having a plurality of laser-cut holes.
46. The device of claim 42 comprising a third barb cut from the sheet-like body and having a sharpened distal end and a proximal end formed from the sheet-like body, the connecting member being cut from the sheet-like body to connect to the proximal end of the third barb.
47. The device of claim 46 in which the three barbs lie in generally the same plane.
48. The device of claim 39 in which the barbs and the connecting member are machined from a single piece of extracellular matrix.
49. The device of claim 39 in which the barbs are machined from extracellular matrix cured to be hard and rigid and each barb has a proximal end portion configured to receive an end of the connecting member.
50. The device of claim 49 in which the connecting member is machined from extracellular matrix.
51. A device for anchoring a bone plug in an opening formed in a bone, the device comprising a mass of naturally occurring extracellular matrix formed into a rigid and hardened member configured to be wedged in the opening between the bone plug and the bone.
52. The device of claim 51 in which the member has a body portion formed with outwardly extending barbs to dig into the bone plug and bone.
53. The device of claim 52 in which the member is provided with a connecting portion to extend into the bone plug.
54. The device claim 51 in which the member is elongated to extend axially along side the bone plug, the member having a plurality of radially outwardly and longitudinally extending fins to dig into the bone plug and bone.
55. The device of claim 54 in which the elongated member is cannulated longitudinally to be sleeved over an elongated guide member such as a K-wire.
56. The device of claim 51 in which the matrix is SIS.
57. The device of claim 56 in which the SIS is cured by drying at room temperature to form the rigid and hardened member.
58. The device of claim 56 in which the SIS has a hardness of about 70 on the “D” scale.
59. The device of claim 51 in which the member is formed in the shape of a screw to be threaded into the opening between the bone plug and bone.
60. A method for anchoring a bone plug into an opening formed in a bone for receiving the plug, the method comprising the steps of:
(a) providing a member formed into a rigid and hardened mass of naturally occurring extracellular matrix, and
(b) placing the member into the opening between the bone plug and the bone.
61. The method of claim 60 in which the member is elongated to extend alongside the bone plug to be wedged between the bone plug and bone.
62. The method of claim 60 in which the member is elongated and threaded to provide a screw to be threaded between the bone plug and the bone.
63. The method of claim 60 in which the bone opening is formed with cylindrical wall and a bottom to receive a cylindrical bone plug, and the placing step comprising placing the member in the opening to engage the bone plug and the bone.
64. The method of claim 63 in the member is provided as a double-ended tack, one end of which extends into the bottom of the opening and the other end of which extends into a bottom surface of the bone plug.
65. The method of claim 64 in which the bottom surface of the bone plug is formed to have a split end, and the placing step further comprises forcing the bone plug split end over the other end of the tack to wedge the bone plug outwardly against the bone opening wall.
66. The method of claim 65 in which the split end of the bone plug is provided with a central pilot hole for receiving the other end of the tack.
67. The method of claim 60 in which the matrix is SIS.
68. The method of claim 67 in which the SIS is cured by drying at room temperature to form the rigid and hardened member.
69. The method of claim 68 in which the SIS has a hardness of about 70 on the “D” scale.
70. The method of claim 60 in which the member is provided with barbs that dig into the bone plug and the bone.
71. A device for attaching a soft tissue to a bone that has been prepared with an opening to receive the device, the device being formed from a hardened mass of naturally occurring extracellular matrix to form an elongated body to be received in the opening, the body having a channel therein for receiving a portion of the soft tissue, the body being configured to collapse inwardly to grip and hold the soft tissue portion in the channel when the body is inserted into the opening.
72. The device of claim 71 in which the body is elongated and formed generally about an axis, the body having a threaded outer surface to accomplish threading the device into the bone opening.
73. The device of claim 72 in which the body is formed such that the channel is a central bore extending through at least a portion of the body, the body having an axially extending slot opening between the channel and the outer surface to accommodate the inward collapse of the device as the device is threaded into the bone opening.
74. The device of claim 71 in which the matrix is SIS.
75. The device of claim 74 in which the mass of SIS is dried to be hardened and then machined to have external threads for threadedly engaging the bone opening.
76. The device of claim 75 in which the device is provided with an axial slot to accommodate the inward collapse of the device as it is threaded into the bone opening.
77. The device of claim 71 in which the body is elongated and formed generally about an axis, the body having an outer surface providing radially outwardly extending engagers to engage into bone.
78. The device of claim 71 in which the engagers are formed to have axially and radially inclined surfaces that force the device to collapse inwardly.
79. An orthopedic device comprising a mass of naturally occurring extracellular matrix having a hardness greater than 30 HRD on the Rockwell D Scale.
80. The orthopedic device of claim 79 wherein the mass of naturally occurring extracellular matrix has a hardness of at least 50 HRD on the Rockwell D scale.
81. The orthopedic device of claim 79 wherein the mass of naturally occurring extracellular matrix has a hardness of at least 60 HRD on the Rockwell D scale.
82. The orthopedic device of claim 79 wherein the mass of naturally occurring extracellular matrix has a density greater than 0.5 g/cc.
83. The orthopedic device of claim 79 wherein the mass of naturally occurring extracellular matrix has a density greater than 0.7 g/cc.
84. The orthopedic device of claim 79 wherein the device comprises a composite with a material selected from the group consisting of:
a bioactive agent;
a biologically derived agent;
a biological lubricant;
a biocompatible polymer;
a biocompatible inorganic material;
cells;
chondrocytes;
osteocytes;
synoviocytes;
a naturally occurring ECM that has a hardness less than 70 HRD on the Rockwell D Scale;
a naturally occurring ECM having a density less than 0.7 g/cc;
a mat including a nonwoven naturally occurring ECM;
braided naturally occurring ECM;
an ECM foam;
an ECM laminate;
an ECM woven;
a biologically absorbable polymer laminate;
a biologically absorbable polymer foam;
a biologically absorbable polymer woven material; and
a mat including a nonwoven naturally occurring biologically absorbable polymer.
85. The orthopedic device of claim 79 wherein the device comprises a configuration selected from the group consisting:
an orthopedic tack comprising a monolithic head portion and a body portion;
an anchor for attaching soft tissue to bone, the device having a portion configured to engage soft tissue and an integral portion configured to engage bone;
an anchor comprising at least two spaced apart barbs, each barb having a sharpened distal end and a proximal end, the device further comprising a member connecting the proximal ends of the barbs;
an anchor comprising at least two spaced apart barbs and an integral member connecting the two barbs;
an anchor for anchoring a bone plug in an opening formed in bone, the naturally occurring extracellular matrix being configured to be wedged between the bone plug and the bone;
an anchor comprising a body having a channel therein, the body being configured to collapse inwardly under compression; and
a outer shell portion and an inner portion surrounded by the shell, wherein the outer shell portion has a hardness greater than 30 HRD on the Rockwell D Scale and the inner portion has a hardness less than 50 HRD on the Rockwell D Scale.
86. The orthopedic device of claim 85 wherein the device is a composite with a material selected from the group consisting of:
a bioactive agent;
a biologically derived agent;
a biological lubricant;
a biocompatible polymer;
a biocompatible inorganic material;
cells;
chondrocytes;
osteocytes;
synoviocytes;
a naturally occurring extracellular matrix that has a hardness less than 70 HRD on the Rockwell D Scale;
a naturally occurring extracellular matrix having a density less than 0.7 g/cc;
a mat of nonwoven naturally occurring extracellular matrix;
an ECM foam;
an ECM laminate;
an ECM woven;
a biologically absorbable polymer laminate;
a biologically absorbable polymer foam;
a biologically absorbable polymer woven; and
a mat of nonwoven naturally occurring biologically absorbable polymer.
87. The orthopedic device of claim 86 wherein the mass of naturally occurring extracellular matrix has a hardness of at least 60 HRD on the Rockwell D Scale.
88. The orthopedic device of claim 86 wherein the mass of naturally occurring extracellular matrix has a hardness of at least 70 HRD on the Rockwell D scale.
89. A composite orthopedic device comprising two connected portions, each portion comprising naturally occurring extracellular matrix material, each portion having a hardness and a density, wherein one portion is configured for anchoring the device to native tissue and has a hardness of not less than 30 HRD on the Rockwell D Scale and a density greater than 0.5 g/cc, and the other portion has a different configuration, a different hardness and a different density.
90. The composite orthopedic device of claim 89 wherein at least one of the portions has a density of not less than 0.7 g/cc.
91. The composite device of claim 89 wherein at least one of the portions comprises a material selected from the group consisting of:
a bioactive agent;
a biologically derived agent;
a biological lubricant;
a biocompatible polymer;
a biocompatible inorganic material;
cells;
chondrocytes;
osteocytes;
synoviocytes;
a mat including nonwoven naturally occurring extracellular matrix;
an ECM foam;
an ECM laminate;
an ECM woven;
a toughened ECM material;
a biologically absorbable polymer laminate;
a biologically absorbable polymer foam;
a biologically absorbable polymer woven; and
a mat including nonwoven naturally occurring biologically absorbable polymer.
92. The composite device of claim 89 wherein the device comprises a configuration selected from the group consisting of:
an orthopedic tack comprising a monolithic head portion and a body portion;
an anchor for attaching soft tissue to bone, the device having a portion configured to engage soft tissue and an integral portion configured to engage bone;
an anchor comprising at least two spaced apart barbs, each barb having a sharpened distal end and a proximal end, the device further comprising a member connecting the proximal ends of the barbs;
an anchor comprising at least two spaced apart barbs and an integral member connecting the two barbs;
an anchor for anchoring a bone plug in an opening formed in bone, at least part of the device being configured to be wedged between the bone plug and the bone;
an anchor comprising a body having a channel therein, the body being configured to collapse inwardly under compression;
a meniscal repair device comprising a pair of barbs and a sheet of naturally occurring extracellular matrix material extending between the barbs;
an outer shell portion and an inner portion surrounded by the shell, wherein the outer shell portion has a density greater than the inner portion; and
a wedge-shaped body having an upper panel and a lower panel angularly separated to define an apex portion and a base portion, the panels being formed of a naturally-occurring extracellular matrix.
93. An orthopedic device comprising bioremodelable collageneous tissue matrix having a hardness greater than 30 HRD on the Rockwell D Scale.
94. The orthopedic device of claim 93 wherein the bioremodelable collageneous tissue matrix has a hardness of at least 60 HRD on the Rockwell D scale.
95. The orthopedic device of claim 93 wherein the bioremodelable collageneous tissue matrix has a hardness of at least 70 HRD on the Rockwell D scale.
96. The orthopedic device of claim 93 wherein the bioremodelable collageneous tissue matrix has a density greater than 0.5 g/cc.
97. The orthopedic device of claim 96 wherein the bioremodelable collageneous tissue matrix has a density greater than 0.7 g/cc.
98. The orthopedic device of claim 93 wherein the device further comprises a material selected from the group consisting of:
a bioactive agent;
a biologically derived agent;
a biological lubricant;
a biocompatible polymer;
a biocompatible inorganic material;
cells;
chondrocytes;
osteocytes;
synoviocytes;
a naturally occurring bioremodelable collageneous tissue matrix that has a hardness less than 70 HRD on the Rockwell D Scale;
a naturally occurring bioremodelable collageneous tissue matrix having a density less than 0.7 g/cc;
a mat including a nonwoven naturally occurring bioremodelable collageneous tissue matrix;
braided naturally occurring bioremodelable collageneous tissue matrix;
a foam comprising bioremodelable collageneous tissue matrix;
a laminate comprising bioremodelable collageneous tissue matrix;
a woven material comprising bioremodelable collageneous tissue matrix;
a biologically absorbable polymer laminate;
a biologically absorbable polymer foam;
a biologically absorbable polymer woven material; and
a mat including a nonwoven biologically absorbable polymer.
99. The orthopedic device of claim 93 wherein the device comprises a configuration selected from the group consisting of:
an orthopedic tack comprising a monolithic head portion and a body portion;
an anchor for attaching soft tissue to bone, the device having a portion configured to engage soft tissue and an integral portion configured to engage bone;
an anchor comprising at least two spaced apart barbs, each barb having a sharpened distal end and a proximal end, the device further comprising a member connecting the proximal ends of the barbs;
an anchor comprising at least two spaced apart barbs and an integral member connecting the two barbs;
an anchor for anchoring a bone plug in an opening formed in bone, the bioremodelable collageneous tissue matrix being configured to be wedged between the bone plug and the bone;
an anchor comprising a body having a channel therein, the body being configured to collapse inwardly under compression; and
a outer shell portion and an inner portion surrounded by the shell, wherein the outer shell portion has a hardness greater than 50 HRD on the Rockwell D Scale and the inner portion has a hardness less than 70 HRD on the Rockwell D Scale.
100. The orthopedic device of claim 99 wherein the device is a composite with a material selected from the group consisting of:
a bioactive agent;
a biologically derived agent;
a biological lubricant;
a biocompatible polymer;
a biocompatible inorganic material;
cells;
chondrocytes;
osteocytes;
synoviocytes;
a naturally occurring bioremodelable collageneous tissue matrix that has a hardness less than 70 HRD on the Rockwell D Scale;
a naturally occurring bioremodelable collageneous tissue matrix having a density less than 0.7 g/cc;
a mat of nonwoven naturally occurring bioremodelable collageneous tissue matrix;
a foam comprising bioremodelable collageneous tissue matrix;
a laminate comprising bioremodelable collageneous tissue matrix;
a woven material comprising bioremodelable collageneous tissue matrix;
a biologically absorbable polymer laminate;
a biologically absorbable polymer foam;
a biologically absorbable polymer woven; and
a mat of nonwoven biologically absorbable polymer.
101. The orthopedic device of claim 100 wherein the bioremodelable collageneous tissue matrix has a hardness of at least 60 HRD on the Rockwell D Scale.
102. The orthopedic device of claim 100 wherein the bioremodelable collageneous tissue matrix has a hardness of at least 70 HRD on the Rockwell D scale.
103. A composite orthopedic device comprising two connected portions, each portion comprising naturally occurring bioremodelable collageneous tissue matrix, each portion having a hardness and a density, wherein one portion has a hardness of no less than 30 HRD on the Rockwell D Scale and a density greater than 0.5 g/cc, and the other portion has a different hardness and a different density.
104. The composite orthopedic device of claim 103 wherein at least one of the portions has a density of not less than 0.7 g/cc.
105. The composite device of claim 103 wherein at least one of the portions comprises a material selected from the group consisting of:
a bioactive agent;
a biologically derived agent;
a biological lubricant;
a biocompatible polymer;
a biocompatible inorganic material;
cells;
chondrocytes;
osteocytes;
synoviocytes;
a mat including nonwoven naturally occurring bioremodelable collageneous tissue matrix;
a foam comprising bioremodelable collageneous tissue matrix;
a laminate comprising bioremodelable collageneous tissue matrix;
a woven material comprising bioremodelable collageneous tissue matrix;
a toughened bioremodelable collageneous tissue matrix material;
a biologically absorbable polymer laminate;
a biologically absorbable polymer foam;
a biologically absorbable polymer woven; and
a mat including nonwoven biologically absorbable polymer.
106. The composite device of claim 103 wherein the device comprises a configuration selected from the group consisting of:
an orthopedic tack comprising a monolithic head portion and a body portion;
an anchor for attaching soft tissue to bone, the device having a portion configured to engage soft tissue and an integral portion configured to engage bone;
an anchor comprising at least two spaced apart barbs, each barb having a sharpened distal end and a proximal end, the device further comprising a member connecting the proximal ends of the barbs;
an anchor comprising at least two spaced apart barbs and an integral member connecting the two barbs;
an anchor for anchoring a bone plug in an opening formed in bone, at least part of the device being configured to be wedged between the bone plug and the bone;
an anchor comprising a body having a channel therein, the body being configured to collapse inwardly under compression;
a meniscal repair device comprising a pair of barbs and a sheet of naturally occurring extracellular matrix material extending between the barbs; and
an outer shell portion and an inner portion surrounded by the shell, wherein the outer shell portion has a density greater than the inner portion.
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Cited By (197)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030023316A1 (en) * | 2000-08-04 | 2003-01-30 | Brown Laura Jean | Hybrid biologic-synthetic bioabsorable scaffolds |
US20030033021A1 (en) * | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration scaffold and method |
US20030036797A1 (en) * | 2001-07-16 | 2003-02-20 | Prasanna Malaviya | Meniscus regeneration device and method |
US20030044444A1 (en) * | 2001-07-16 | 2003-03-06 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20030078617A1 (en) * | 2001-07-16 | 2003-04-24 | Schwartz Herbert E. | Unitary surgical device and method |
US20040059431A1 (en) * | 2000-08-04 | 2004-03-25 | Plouhar Pamela L. | Reinforced small intestinal submucosa |
US20040092937A1 (en) * | 2000-10-23 | 2004-05-13 | Criscuolo Christopher J. | Absorbable fastener and applying apparatus |
US20040098045A1 (en) * | 1999-02-02 | 2004-05-20 | Grafton R. Donald | Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using the same |
US20040143344A1 (en) * | 2001-07-16 | 2004-07-22 | Prasanna Malaviya | Implantable tissue repair device and method |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20040181230A1 (en) * | 2003-03-13 | 2004-09-16 | Rizzo Rosario | Micronail and method for dental use |
US20040220574A1 (en) * | 2001-07-16 | 2004-11-04 | Pelo Mark Joseph | Device from naturally occuring biologically derived materials |
US20040230303A1 (en) * | 2003-05-16 | 2004-11-18 | Gomes Katherine A. | Cartilage allograft plug |
US20050059905A1 (en) * | 2003-09-11 | 2005-03-17 | Robert Boock | Tissue extraction and maceration device |
US20050090139A1 (en) * | 2002-03-28 | 2005-04-28 | Rowland White | Contact |
US20050136764A1 (en) * | 2003-12-18 | 2005-06-23 | Sherman Michael C. | Designed composite degradation for spinal implants |
US20050149187A1 (en) * | 2000-08-28 | 2005-07-07 | Ron Clark | Method and implant for securing ligament replacement into the knee |
US20050222687A1 (en) * | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
JP2005305162A (en) * | 2004-04-20 | 2005-11-04 | Depuy Mitek Inc | Meniscus repair scaffold |
US20050251268A1 (en) * | 2003-05-16 | 2005-11-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050249771A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050273155A1 (en) * | 2002-08-20 | 2005-12-08 | Bahler Clinton D | Endoluminal device with extracellular matrix material and methods |
US20050273003A1 (en) * | 2003-10-15 | 2005-12-08 | Arthrotek, Inc. | Method and apparatus for graft fixation |
US20060041261A1 (en) * | 2004-08-17 | 2006-02-23 | Osypka Thomas P | Apparatus and method for attaching connective tissue to bone |
US20060058799A1 (en) * | 2004-02-10 | 2006-03-16 | Robert Elson | Ligament repair apparatus and method |
EP1652484A1 (en) | 2004-10-29 | 2006-05-03 | DePuy Products, Inc. | Instruments, kit and method for suture managment |
EP1652473A1 (en) | 2004-10-29 | 2006-05-03 | DePuy Products, Inc. | Implant system with sizing templates |
US20060128296A1 (en) * | 2004-10-29 | 2006-06-15 | Schwan Wade E | Intestine processing device and associated method |
US20060135638A1 (en) * | 2004-12-22 | 2006-06-22 | Pedrozo Hugo A | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
US20060178680A1 (en) * | 2005-02-07 | 2006-08-10 | Regen Biologics, Inc. | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US20060190042A1 (en) * | 2004-11-05 | 2006-08-24 | Arthrotek, Inc. | Tissue repair assembly |
US20060189993A1 (en) * | 2004-11-09 | 2006-08-24 | Arthrotek, Inc. | Soft tissue conduit device |
US20060210643A1 (en) * | 2003-04-29 | 2006-09-21 | Truncale Katherine A G | Cartilage repair mixture containing allograft chondrocytes |
US20060211953A1 (en) * | 2004-10-29 | 2006-09-21 | Zannis Anthony D | Coordinate instrument set |
US20060263335A1 (en) * | 2003-03-27 | 2006-11-23 | Regentec Ltd. | Porous matrix |
US20070009610A1 (en) * | 2005-07-11 | 2007-01-11 | Carina Syring | Engineered osteochondral construct for treatment of articular cartilage defects |
US20070060923A1 (en) * | 2005-09-12 | 2007-03-15 | Arthrex, Inc. | Mesh reinforced tissue anchor |
US20070088445A1 (en) * | 2005-04-29 | 2007-04-19 | Patel Umesh H | Fistula graft with deformable sheet-form material |
US20070114261A1 (en) * | 2005-11-23 | 2007-05-24 | Ethicon Endo-Surgery, Inc. | Surgical stapler with a bendable end effector |
AU2002354915B2 (en) * | 2001-07-16 | 2008-03-20 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US20080082128A1 (en) * | 2006-09-29 | 2008-04-03 | Arthrotek, Inc. | Method and apparatus for forming a self-locking adjustable suture loop |
US20080109018A1 (en) * | 2006-09-12 | 2008-05-08 | Small Bone Innovations International Sas | Surgical clip |
US20080140094A1 (en) * | 2006-12-11 | 2008-06-12 | Schwartz Herbert E | Unitary surgical device and method |
US20080154316A1 (en) * | 2004-08-09 | 2008-06-26 | Inbone Technologies, Inc. | Systems and methods for the fixation or fusion bone related applications |
US20080220044A1 (en) * | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US20080228271A1 (en) * | 2007-03-13 | 2008-09-18 | Biomet Sports Medicine, Inc. | Method and apparatus for graft fixation |
US20080234715A1 (en) * | 2003-09-11 | 2008-09-25 | Depuy Mitek, Inc. | Tissue Extraction and Collection Device |
US20080274157A1 (en) * | 2003-04-29 | 2008-11-06 | Gordana Vunjak-Novakovic | Cartilage implant plug with fibrin glue and method for implantation |
US20090149893A1 (en) * | 2007-12-05 | 2009-06-11 | Semler Eric J | Cancellous Bone Implant for Cartilage Repair |
US20090157194A1 (en) * | 2006-03-10 | 2009-06-18 | Takiron Co., Ltd. | Implant composite material |
US20090227843A1 (en) * | 2007-09-12 | 2009-09-10 | Smith Jeffrey A | Multi-instrument access devices and systems |
US20090259261A1 (en) * | 2004-08-09 | 2009-10-15 | Mark A Reiley | Systems and methods for the fixation or fusion of bone at or near a sacroiliac joint |
US20090291112A1 (en) * | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
US20090319045A1 (en) * | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US20100015202A1 (en) * | 2007-03-06 | 2010-01-21 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US20100049244A1 (en) * | 2008-08-20 | 2010-02-25 | Tyco Healthcare Group Lp | Double threaded tissue tack |
US20100063541A1 (en) * | 2008-09-05 | 2010-03-11 | Pegasus Biologies, Inc. | Oblong cross-sectional tissue fixation peg |
US20100131074A1 (en) * | 2005-09-13 | 2010-05-27 | Takiron Co., Ltd. | Composite porous object |
US7749250B2 (en) | 2006-02-03 | 2010-07-06 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US20100280406A1 (en) * | 2003-03-28 | 2010-11-04 | Ethicon, Inc. | Tissue Collection Device and Methods |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7857830B2 (en) | 2006-02-03 | 2010-12-28 | Biomet Sports Medicine, Llc | Soft tissue repair and conduit device |
US20110060183A1 (en) * | 2007-09-12 | 2011-03-10 | Salvatore Castro | Multi-instrument access devices and systems |
US7905903B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US7905904B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US7909851B2 (en) | 2006-02-03 | 2011-03-22 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US7914808B2 (en) | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US7914539B2 (en) | 2004-11-09 | 2011-03-29 | Biomet Sports Medicine, Llc | Tissue fixation device |
US20110087296A1 (en) * | 2004-08-09 | 2011-04-14 | Si-Bone, Inc. | Systems and methods for the fixation of fusion of bone using compressive implants |
US20110118841A1 (en) * | 2004-08-09 | 2011-05-19 | Si-Bone, Inc. | Apparatus, systems, and methods for achieving trans-iliac lumbar fusion |
US20110118796A1 (en) * | 2004-08-09 | 2011-05-19 | Reiley Mark A | Systems and methods for the fixation or fusion of bone |
US20110125268A1 (en) * | 2004-08-09 | 2011-05-26 | Si-Bone, Inc. | Apparatus, systems, and methods for achieving lumbar facet fusion |
US7959650B2 (en) | 2006-09-29 | 2011-06-14 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US20110184231A1 (en) * | 2009-07-28 | 2011-07-28 | Page Brett M | Deflectable instrument ports |
US20110185560A1 (en) * | 2008-08-18 | 2011-08-04 | Qioptiq Photonics Gmbh & Co. Kg | Method for producing an objective |
US8002778B1 (en) | 2004-06-28 | 2011-08-23 | Biomet Sports Medicine, Llc | Crosspin and method for inserting the same during soft ligament repair |
US8034090B2 (en) | 2004-11-09 | 2011-10-11 | Biomet Sports Medicine, Llc | Tissue fixation device |
US8088130B2 (en) | 2006-02-03 | 2012-01-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8118836B2 (en) | 2004-11-05 | 2012-02-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8128640B2 (en) | 2005-02-07 | 2012-03-06 | Ivy Sports Medicine LLC | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US8128658B2 (en) | 2004-11-05 | 2012-03-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US8137382B2 (en) | 2004-11-05 | 2012-03-20 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
EP2446837A2 (en) | 2010-10-28 | 2012-05-02 | Tyco Healthcare Group LP | Wound closure device including barbed pins |
US8221454B2 (en) | 2004-02-20 | 2012-07-17 | Biomet Sports Medicine, Llc | Apparatus for performing meniscus repair |
US8251998B2 (en) | 2006-08-16 | 2012-08-28 | Biomet Sports Medicine, Llc | Chondral defect repair |
US8298262B2 (en) | 2006-02-03 | 2012-10-30 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8303604B2 (en) | 2004-11-05 | 2012-11-06 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US8343227B2 (en) | 2009-05-28 | 2013-01-01 | Biomet Manufacturing Corp. | Knee prosthesis assembly with ligament link |
US8361113B2 (en) | 2006-02-03 | 2013-01-29 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US20130053975A1 (en) * | 2010-06-02 | 2013-02-28 | Wright Medical Technology, Inc. | Hammer toe implant method |
US8425570B2 (en) | 2004-08-09 | 2013-04-23 | Si-Bone Inc. | Apparatus, systems, and methods for achieving anterior lumbar interbody fusion |
US8470004B2 (en) | 2004-08-09 | 2013-06-25 | Si-Bone Inc. | Apparatus, systems, and methods for stabilizing a spondylolisthesis |
US20130172998A1 (en) * | 2005-12-20 | 2013-07-04 | Depuy Mitek, Llc | Methods for ligament reconstruction |
US20130184768A1 (en) * | 2012-01-12 | 2013-07-18 | Terence Edward McIff | Compact orthopedic anti-rotation device |
US8500818B2 (en) | 2006-09-29 | 2013-08-06 | Biomet Manufacturing, Llc | Knee prosthesis assembly with ligament link |
US8506597B2 (en) | 2011-10-25 | 2013-08-13 | Biomet Sports Medicine, Llc | Method and apparatus for interosseous membrane reconstruction |
WO2013123509A1 (en) * | 2012-02-17 | 2013-08-22 | Bacterin International, Inc. | Adjustable bioactive agent dispersion within a polymeric coating |
US8562647B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for securing soft tissue to bone |
US8562645B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8574235B2 (en) | 2006-02-03 | 2013-11-05 | Biomet Sports Medicine, Llc | Method for trochanteric reattachment |
US8597327B2 (en) | 2006-02-03 | 2013-12-03 | Biomet Manufacturing, Llc | Method and apparatus for sternal closure |
US8652172B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Flexible anchors for tissue fixation |
US8652171B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US8672969B2 (en) | 2006-09-29 | 2014-03-18 | Biomet Sports Medicine, Llc | Fracture fixation device |
US20140166726A1 (en) * | 2014-02-24 | 2014-06-19 | Ethicon Endo-Surgery, Inc. | Staple cartridge including a barbed staple |
US8771352B2 (en) | 2011-05-17 | 2014-07-08 | Biomet Sports Medicine, Llc | Method and apparatus for tibial fixation of an ACL graft |
US8778026B2 (en) | 2012-03-09 | 2014-07-15 | Si-Bone Inc. | Artificial SI joint |
US8801783B2 (en) | 2006-09-29 | 2014-08-12 | Biomet Sports Medicine, Llc | Prosthetic ligament system for knee joint |
US8821494B2 (en) | 2012-08-03 | 2014-09-02 | Howmedica Osteonics Corp. | Surgical instruments and methods of use |
US8840645B2 (en) | 2004-11-05 | 2014-09-23 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US20140331474A1 (en) * | 2013-05-08 | 2014-11-13 | Arthur R. Walters, JR. | Fastening device for driving double-headed fasteners |
US20140371748A1 (en) * | 2013-06-17 | 2014-12-18 | Gc Corporation | Fracture treatment device |
US8936621B2 (en) | 2006-02-03 | 2015-01-20 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8968364B2 (en) | 2006-02-03 | 2015-03-03 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US8998949B2 (en) | 2004-11-09 | 2015-04-07 | Biomet Sports Medicine, Llc | Soft tissue conduit device |
US9017381B2 (en) | 2007-04-10 | 2015-04-28 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US9044321B2 (en) | 2012-03-09 | 2015-06-02 | Si-Bone Inc. | Integrated implant |
US20150150607A1 (en) * | 2012-05-22 | 2015-06-04 | Lifenet Health | Cortical Bone Pin |
US9078644B2 (en) | 2006-09-29 | 2015-07-14 | Biomet Sports Medicine, Llc | Fracture fixation device |
US9149267B2 (en) | 2006-02-03 | 2015-10-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
US9259217B2 (en) | 2012-01-03 | 2016-02-16 | Biomet Manufacturing, Llc | Suture Button |
US9271713B2 (en) | 2006-02-03 | 2016-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for tensioning a suture |
US9314241B2 (en) | 2011-11-10 | 2016-04-19 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US9357991B2 (en) | 2011-11-03 | 2016-06-07 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US9370350B2 (en) | 2011-11-10 | 2016-06-21 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US9381013B2 (en) | 2011-11-10 | 2016-07-05 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9402620B2 (en) | 2013-03-04 | 2016-08-02 | Howmedica Osteonics Corp. | Knotless filamentary fixation devices, assemblies and systems and methods of assembly and use |
US9445803B2 (en) | 2011-11-23 | 2016-09-20 | Howmedica Osteonics Corp. | Filamentary suture anchor |
US9463013B2 (en) | 2013-03-13 | 2016-10-11 | Stryker Corporation | Adjustable continuous filament structure and method of manufacture and use |
US9474561B2 (en) | 2013-11-19 | 2016-10-25 | Wright Medical Technology, Inc. | Two-wire technique for installing hammertoe implant |
US9498273B2 (en) | 2010-06-02 | 2016-11-22 | Wright Medical Technology, Inc. | Orthopedic implant kit |
US9498266B2 (en) | 2014-02-12 | 2016-11-22 | Wright Medical Technology, Inc. | Intramedullary implant, system, and method for inserting an implant into a bone |
US9504582B2 (en) | 2012-12-31 | 2016-11-29 | Wright Medical Technology, Inc. | Ball and socket implants for correction of hammer toes and claw toes |
US9538998B2 (en) | 2006-02-03 | 2017-01-10 | Biomet Sports Medicine, Llc | Method and apparatus for fracture fixation |
US9545274B2 (en) | 2014-02-12 | 2017-01-17 | Wright Medical Technology, Inc. | Intramedullary implant, system, and method for inserting an implant into a bone |
US9603643B2 (en) | 2010-06-02 | 2017-03-28 | Wright Medical Technology, Inc. | Hammer toe implant with expansion portion for retrograde approach |
US9615822B2 (en) | 2014-05-30 | 2017-04-11 | Biomet Sports Medicine, Llc | Insertion tools and method for soft anchor |
US9662157B2 (en) | 2014-09-18 | 2017-05-30 | Si-Bone Inc. | Matrix implant |
US9701940B2 (en) | 2005-09-19 | 2017-07-11 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
US9700291B2 (en) | 2014-06-03 | 2017-07-11 | Biomet Sports Medicine, Llc | Capsule retractor |
US9724139B2 (en) | 2013-10-01 | 2017-08-08 | Wright Medical Technology, Inc. | Hammer toe implant and method |
US9724140B2 (en) | 2010-06-02 | 2017-08-08 | Wright Medical Technology, Inc. | Tapered, cylindrical cruciform hammer toe implant and method |
US9757119B2 (en) | 2013-03-08 | 2017-09-12 | Biomet Sports Medicine, Llc | Visual aid for identifying suture limbs arthroscopically |
US9788826B2 (en) | 2013-03-11 | 2017-10-17 | Howmedica Osteonics Corp. | Filamentary fixation device and assembly and method of assembly, manufacture and use |
US9801708B2 (en) | 2004-11-05 | 2017-10-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9808296B2 (en) | 2014-09-18 | 2017-11-07 | Wright Medical Technology, Inc. | Hammertoe implant and instrument |
US9808242B2 (en) | 2012-04-06 | 2017-11-07 | Howmedica Osteonics Corp. | Knotless filament anchor for soft tissue repair |
US9839448B2 (en) | 2013-10-15 | 2017-12-12 | Si-Bone Inc. | Implant placement |
US9918826B2 (en) | 2006-09-29 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US9918827B2 (en) | 2013-03-14 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US9936983B2 (en) | 2013-03-15 | 2018-04-10 | Si-Bone Inc. | Implants for spinal fixation or fusion |
US9949843B2 (en) | 2004-08-09 | 2018-04-24 | Si-Bone Inc. | Apparatus, systems, and methods for the fixation or fusion of bone |
US9955980B2 (en) | 2015-02-24 | 2018-05-01 | Biomet Sports Medicine, Llc | Anatomic soft tissue repair |
US9986992B2 (en) | 2014-10-28 | 2018-06-05 | Stryker Corporation | Suture anchor and associated methods of use |
US10039543B2 (en) | 2014-08-22 | 2018-08-07 | Biomet Sports Medicine, Llc | Non-sliding soft anchor |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US10080597B2 (en) | 2014-12-19 | 2018-09-25 | Wright Medical Technology, Inc. | Intramedullary anchor for interphalangeal arthrodesis |
US10136886B2 (en) | 2013-12-20 | 2018-11-27 | Biomet Sports Medicine, Llc | Knotless soft tissue devices and techniques |
US10166033B2 (en) | 2014-09-18 | 2019-01-01 | Si-Bone Inc. | Implants for bone fixation or fusion |
US10178991B2 (en) | 2015-04-22 | 2019-01-15 | Sofradim Production | Method for forming a barbed suture and the barbed suture thus obtained |
US10231744B2 (en) | 2009-08-20 | 2019-03-19 | Howmedica Osteonics Corp. | Flexible ACL instrumentation, kit and method |
US10357260B2 (en) | 2015-11-02 | 2019-07-23 | First Ray, LLC | Orthopedic fastener, retainer, and guide methods |
US10363140B2 (en) | 2012-03-09 | 2019-07-30 | Si-Bone Inc. | Systems, device, and methods for joint fusion |
US10376367B2 (en) | 2015-07-02 | 2019-08-13 | First Ray, LLC | Orthopedic fasteners, instruments and methods |
US10376206B2 (en) | 2015-04-01 | 2019-08-13 | Si-Bone Inc. | Neuromonitoring systems and methods for bone fixation or fusion procedures |
US10426533B2 (en) | 2012-05-04 | 2019-10-01 | Si-Bone Inc. | Fenestrated implant |
US10433944B2 (en) | 2015-04-23 | 2019-10-08 | Sofradim Production | Package for a surgical mesh |
US10517587B2 (en) | 2006-02-03 | 2019-12-31 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US10568616B2 (en) | 2014-12-17 | 2020-02-25 | Howmedica Osteonics Corp. | Instruments and methods of soft tissue fixation |
US10610211B2 (en) | 2013-12-12 | 2020-04-07 | Howmedica Osteonics Corp. | Filament engagement system and methods of use |
US10675016B2 (en) | 2015-10-30 | 2020-06-09 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Suture sleeve patch and methods of delivery within an existing arthroscopic workflow |
US10702260B2 (en) | 2016-02-01 | 2020-07-07 | Medos International Sàrl | Soft tissue fixation repair methods using tissue augmentation scaffolds |
US20200345508A1 (en) * | 2005-05-24 | 2020-11-05 | Si-Bone Inc. | Apparatus, systems, and methods for the fixation or fusion of bone |
USD902405S1 (en) | 2018-02-22 | 2020-11-17 | Stryker Corporation | Self-punching bone anchor inserter |
US10912551B2 (en) | 2015-03-31 | 2021-02-09 | Biomet Sports Medicine, Llc | Suture anchor with soft anchor of electrospun fibers |
US10932769B2 (en) | 2016-05-26 | 2021-03-02 | Ivy Sports Medicine, Llc | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US10980925B1 (en) | 2008-10-14 | 2021-04-20 | A Hoyos Llc | High definition liposculpture |
US11116519B2 (en) | 2017-09-26 | 2021-09-14 | Si-Bone Inc. | Systems and methods for decorticating the sacroiliac joint |
US11147688B2 (en) | 2013-10-15 | 2021-10-19 | Si-Bone Inc. | Implant placement |
US11234830B2 (en) | 2019-02-14 | 2022-02-01 | Si-Bone Inc. | Implants for spinal fixation and or fusion |
US11259792B2 (en) | 2006-02-03 | 2022-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US11259794B2 (en) | 2006-09-29 | 2022-03-01 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US11311287B2 (en) | 2006-02-03 | 2022-04-26 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US11331094B2 (en) | 2013-04-22 | 2022-05-17 | Stryker Corporation | Method and apparatus for attaching tissue to bone |
US11369419B2 (en) | 2019-02-14 | 2022-06-28 | Si-Bone Inc. | Implants for spinal fixation and or fusion |
US11446062B2 (en) * | 2013-03-14 | 2022-09-20 | Kinamed, Inc. | Vector compression system |
USD968609S1 (en) | 2019-09-12 | 2022-11-01 | Lifenet Health | Medical implant device |
USD968608S1 (en) | 2019-08-12 | 2022-11-01 | Lifenet Health | Medical implant device |
US11484401B2 (en) | 2016-02-01 | 2022-11-01 | Medos International Sarl | Tissue augmentation scaffolds for use in soft tissue fixation repair |
US11571245B2 (en) | 2019-11-27 | 2023-02-07 | Si-Bone Inc. | Bone stabilizing implants and methods of placement across SI joints |
US20230082982A1 (en) * | 2021-09-10 | 2023-03-16 | Olympus Corporation | Suture method |
US11607314B2 (en) * | 2014-10-22 | 2023-03-21 | Biomet C.V. | Method and apparatus for bone fixation |
US11684467B2 (en) * | 2016-11-07 | 2023-06-27 | Acuitive Technologies, Inc. | In-situ curing biodegradable anchor with reinforcement |
US11690722B2 (en) * | 2008-02-28 | 2023-07-04 | Biopoly, Llc | Partial joint resurfacing implant, instrumentation, and method |
US11752011B2 (en) | 2020-12-09 | 2023-09-12 | Si-Bone Inc. | Sacro-iliac joint stabilizing implants and methods of implantation |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6520964B2 (en) | 2000-05-01 | 2003-02-18 | Std Manufacturing, Inc. | System and method for joint resurface repair |
US8177841B2 (en) | 2000-05-01 | 2012-05-15 | Arthrosurface Inc. | System and method for joint resurface repair |
US7678151B2 (en) | 2000-05-01 | 2010-03-16 | Ek Steven W | System and method for joint resurface repair |
US6610067B2 (en) * | 2000-05-01 | 2003-08-26 | Arthrosurface, Incorporated | System and method for joint resurface repair |
US7163541B2 (en) | 2002-12-03 | 2007-01-16 | Arthrosurface Incorporated | Tibial resurfacing system |
CA2365376C (en) | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US7824701B2 (en) | 2002-10-18 | 2010-11-02 | Ethicon, Inc. | Biocompatible scaffold for ligament or tendon repair |
US7901408B2 (en) | 2002-12-03 | 2011-03-08 | Arthrosurface, Inc. | System and method for retrograde procedure |
US20040167572A1 (en) * | 2003-02-20 | 2004-08-26 | Roth Noah M. | Coated medical devices |
US8388624B2 (en) | 2003-02-24 | 2013-03-05 | Arthrosurface Incorporated | Trochlear resurfacing system and method |
US8197837B2 (en) | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
US8226715B2 (en) | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
US10583220B2 (en) | 2003-08-11 | 2020-03-10 | DePuy Synthes Products, Inc. | Method and apparatus for resurfacing an articular surface |
WO2005051231A2 (en) | 2003-11-20 | 2005-06-09 | Arthrosurface, Inc. | Retrograde delivery of resurfacing devices |
CA2593182A1 (en) | 2003-11-20 | 2006-07-13 | Arthrosurface, Inc. | System and method for retrograde procedure |
US7951163B2 (en) | 2003-11-20 | 2011-05-31 | Arthrosurface, Inc. | Retrograde excision system and apparatus |
US7901461B2 (en) | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
EP1711128A4 (en) * | 2004-01-16 | 2008-07-30 | Osteobiologics Inc | Bone-tendon-bone implant |
US20050222613A1 (en) * | 2004-02-05 | 2005-10-06 | Edwin Ryan | Wound closure device and method for vitrectomy |
US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
CA2556902A1 (en) * | 2004-03-03 | 2005-10-06 | Schwartz Biomedical, Llc | Articular cartilage fixation device and method |
US8137686B2 (en) | 2004-04-20 | 2012-03-20 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
US8221780B2 (en) | 2004-04-20 | 2012-07-17 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
JP2008504107A (en) | 2004-06-28 | 2008-02-14 | アースロサーフィス・インコーポレーテッド | Joint surface replacement system |
FR2874809B1 (en) * | 2004-09-06 | 2008-02-01 | Newdeal Sa Sa | IMPLANT FOR FIXING A BONE GRAFT WITHIN A JOINT TO ENSURE THE ARTHRODESIS OF THE JOINT |
US7828853B2 (en) | 2004-11-22 | 2010-11-09 | Arthrosurface, Inc. | Articular surface implant and delivery system |
US7595062B2 (en) * | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
US8900321B2 (en) * | 2006-03-20 | 2014-12-02 | Zimmer, Inc. | Implant anchoring device |
WO2007112026A2 (en) * | 2006-03-24 | 2007-10-04 | Johnson & Johnson Regenerative Therapeutics, Llc. | Localized delivery of a therapeutic agent by barbed staples |
US20070233268A1 (en) * | 2006-03-31 | 2007-10-04 | Depuy Products, Inc. | Interpositional knee arthroplasty |
US7416889B2 (en) * | 2006-04-27 | 2008-08-26 | Rhode Island Hospital | Methods and compositions for repairing cartilage |
US20080015691A1 (en) * | 2006-06-15 | 2008-01-17 | Depuy Products, Inc. | Orthopaedic implants having bioresorbable posts |
GB0615750D0 (en) * | 2006-08-08 | 2006-09-20 | Royal Berkshire Nhs Foundation | Aglet |
US7942914B2 (en) * | 2006-10-17 | 2011-05-17 | Arthroscopic Innovations Llc | Method and apparatus for surgical repair |
EP2136717B1 (en) | 2006-12-11 | 2013-10-16 | Arthrosurface Incorporated | Retrograde resection apparatus |
FR2914178B1 (en) * | 2007-03-27 | 2010-05-14 | Cie De Rech En Composants Impl | IMPLANTABLE REINFORCEMENT PROSTHESIS WITH MOUNTING MEANS |
US8778012B2 (en) * | 2012-11-27 | 2014-07-15 | Cormatrix Cardiovascular, Inc. | ECM constructs for tissue regeneration |
US20090078343A1 (en) * | 2007-09-24 | 2009-03-26 | Atlas Copco Secoroc Llc | Earthboring tool and method of casehardening |
US8597336B2 (en) * | 2007-12-28 | 2013-12-03 | Howmedica Osteonics Corp. | Apparatus for discrete tissue anchoring for soft tissue repair and method of use |
US9681869B2 (en) | 2008-02-22 | 2017-06-20 | Mimedx Group, Inc. | Biostaples suitable for wrist, hand and other ligament replacements or repairs |
WO2009111481A1 (en) | 2008-03-03 | 2009-09-11 | Arthrosurface Incorporated | Bone resurfacing system and method |
US8353369B2 (en) | 2008-08-06 | 2013-01-15 | Atlas Copco Secoroc, LLC | Percussion assisted rotary earth bit and method of operating the same |
US8777990B2 (en) | 2008-09-08 | 2014-07-15 | Howmedica Osteonics Corp. | Knotless suture anchor for soft tissue repair and method of use |
WO2010040002A1 (en) * | 2008-10-01 | 2010-04-08 | Life Spine, Inc. | Spinal facet fastener |
US9451942B2 (en) * | 2008-11-12 | 2016-09-27 | Howmedica Osteonics Corp. | Insertion tool for knotless suture anchor for soft tissue repair and method of use |
DE112010000680T5 (en) * | 2009-02-23 | 2012-12-13 | Arthrosurface, Inc. | Nanoroutly alloy substrate |
WO2010121246A1 (en) | 2009-04-17 | 2010-10-21 | Arthrosurface Incorporated | Glenoid resurfacing system and method |
US9662126B2 (en) | 2009-04-17 | 2017-05-30 | Arthrosurface Incorporated | Glenoid resurfacing system and method |
WO2016154393A1 (en) | 2009-04-17 | 2016-09-29 | Arthrosurface Incorporated | Glenoid repair system and methods of use thereof |
AU2010256474B2 (en) | 2009-06-04 | 2015-09-10 | Rotation Medical, Inc. | Apparatus for delivering staples to a target tissue |
AU2011222404A1 (en) | 2010-03-05 | 2012-09-27 | Arthrosurface Incorporated | Tibial resurfacing system and method |
WO2014165123A1 (en) | 2013-03-13 | 2014-10-09 | Arrowhead Medical Device Technologies Llc | Hammertoe implant with enhanced gripping surfaces |
US10349987B2 (en) | 2010-04-14 | 2019-07-16 | Arrowhead Medical Device Technologies, Llc | Intramedullary fixation devices |
US8685024B2 (en) | 2010-04-14 | 2014-04-01 | Arrowhead Medical Device Technologies, Llc | Intramedullary fixation device and methods for bone fixation and stabilization |
WO2011137270A1 (en) * | 2010-04-29 | 2011-11-03 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Cell and biofactor printable biopapers |
US20120089197A1 (en) * | 2010-10-10 | 2012-04-12 | Anderson Gregory S | Arthrodesis implant apparatus and method |
KR101241059B1 (en) * | 2011-03-04 | 2013-03-11 | 연세대학교 산학협력단 | Device and Method for Delivery of Drug to the Exterior of Vascular Vessels using Micro-needle |
US9066716B2 (en) | 2011-03-30 | 2015-06-30 | Arthrosurface Incorporated | Suture coil and suture sheath for tissue repair |
EP2804565B1 (en) | 2011-12-22 | 2018-03-07 | Arthrosurface Incorporated | System for bone fixation |
US9468448B2 (en) | 2012-07-03 | 2016-10-18 | Arthrosurface Incorporated | System and method for joint resurfacing and repair |
EP2967688A4 (en) | 2013-03-13 | 2016-11-23 | Arrowhead Medical Device Technologies Llc | Hammertoe implant with asymmetrical head |
EP2967687B1 (en) | 2013-03-13 | 2019-01-09 | Arrowhead Medical Device Technologies LLC | Methods and implants for treating hammertoe and other deformities |
US10383658B2 (en) * | 2013-03-14 | 2019-08-20 | Poly-4 Group, Lp | Vector compression system |
US9345469B2 (en) * | 2013-03-14 | 2016-05-24 | Terry Mattchen | Vector compression system |
EP2986236B8 (en) | 2013-04-15 | 2020-01-15 | Episurf IP Management AB | System of designing a guide tool and/ or surgical kit tools and/or an implant comprising a positioning mark |
US9492200B2 (en) | 2013-04-16 | 2016-11-15 | Arthrosurface Incorporated | Suture system and method |
EP2929850B1 (en) * | 2013-10-11 | 2016-12-21 | Wright Medical Technology, Inc. | Cylindrical cruciform hammer toe implant |
AU2014365821B2 (en) | 2013-12-20 | 2019-10-03 | Crossroads Extremity Systems, Llc | Polyaxial locking hole |
US11607319B2 (en) | 2014-03-07 | 2023-03-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
US10624748B2 (en) | 2014-03-07 | 2020-04-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
US20150250472A1 (en) | 2014-03-07 | 2015-09-10 | Arthrosurface Incorporated | Delivery System for Articular Surface Implant |
AU2014203105B1 (en) * | 2014-03-28 | 2015-03-12 | Wright Medical Technology, Inc. | Hammer toe implant |
PT3160370T (en) | 2014-06-25 | 2021-04-06 | Acumed Llc | Bone fixation with a pin and a collar |
US11202626B2 (en) | 2014-07-10 | 2021-12-21 | Crossroads Extremity Systems, Llc | Bone implant with means for multi directional force and means of insertion |
US10492841B2 (en) | 2014-07-10 | 2019-12-03 | Crossroads Extremity Systems, Llc | Bone implant and means of insertion |
US10123796B2 (en) | 2014-11-04 | 2018-11-13 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
CA2965698A1 (en) | 2014-11-04 | 2016-05-12 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
EP3215025B1 (en) | 2014-11-04 | 2020-12-23 | Rotation Medical, Inc. | Medical implant delivery system |
US10028744B2 (en) * | 2015-08-26 | 2018-07-24 | Ethicon Llc | Staple cartridge assembly including staple guides |
WO2017117437A1 (en) | 2015-12-31 | 2017-07-06 | Rotation Medical, Inc. | Fastener delivery system and related methods |
US11000410B2 (en) * | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
US11864753B2 (en) | 2017-02-06 | 2024-01-09 | Crossroads Extremity Systems, Llc | Implant inserter |
EP3579762A4 (en) | 2017-02-07 | 2021-04-07 | Crossroads Extremity Systems, LLC | Counter-torque implant |
IT201700073581A1 (en) * | 2017-06-30 | 2018-12-30 | Giuseppe Piccinni | LAPAROSCOPIC CONTAINMENT SYSTEM FOR ABDOMINAL HERNIA |
USD870284S1 (en) | 2017-07-31 | 2019-12-17 | Crossroads Extremity Systems, Llc | Osteosynthesis clip |
WO2019028344A1 (en) | 2017-08-04 | 2019-02-07 | Arthrosurface Incorporated | Multicomponent articular surface implant |
US10716558B2 (en) | 2017-08-04 | 2020-07-21 | Ethicon, Inc. | Tissue anchors having bi-directional arrays of barbed pins for joining tissue layers |
EP3720385B1 (en) | 2017-12-07 | 2023-09-27 | Rotation Medical, Inc. | Medical implant delivery system |
GB2609338B (en) | 2019-03-12 | 2023-06-14 | Arthrosurface Inc | Humeral and glenoid articular surface implant systems and methods |
USD961081S1 (en) | 2020-11-18 | 2022-08-16 | Crossroads Extremity Systems, Llc | Orthopedic implant |
Citations (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3562820A (en) * | 1966-08-22 | 1971-02-16 | Bernhard Braun | Tubular sheet and strip form prostheses on a basis of biological tissue |
US4642120A (en) * | 1983-03-23 | 1987-02-10 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Repair of cartilage and bones |
US4976715A (en) * | 1986-05-20 | 1990-12-11 | Concept, Inc. | Repair tack for bodily tissue |
US5102421A (en) * | 1990-06-14 | 1992-04-07 | Wm. E. Anpach, III | Suture anchor and method of forming |
US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
US5236431A (en) * | 1991-07-22 | 1993-08-17 | Synthes | Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor |
US5246441A (en) * | 1989-09-08 | 1993-09-21 | Linvatec Corporation | Bioabsorbable tack for joining bodily tissue |
US5591234A (en) * | 1993-02-01 | 1997-01-07 | Axel Kirsch | Post-surgery orthopedic covering |
US5593441A (en) * | 1992-03-04 | 1997-01-14 | C. R. Bard, Inc. | Method for limiting the incidence of postoperative adhesions |
US5669912A (en) * | 1994-04-26 | 1997-09-23 | Spetzler; Robert F. | Apparatus for securing a cranial piece in position |
US5759205A (en) * | 1994-01-21 | 1998-06-02 | Brown University Research Foundation | Negatively charged polymeric electret implant |
US5795353A (en) * | 1994-05-06 | 1998-08-18 | Advanced Bio Surfaces, Inc. | Joint resurfacing system |
US5830708A (en) * | 1995-06-06 | 1998-11-03 | Advanced Tissue Sciences, Inc. | Methods for production of a naturally secreted extracellular matrix |
US5842477A (en) * | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
US5855619A (en) * | 1994-06-06 | 1999-01-05 | Case Western Reserve University | Biomatrix for soft tissue regeneration |
US5855613A (en) * | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
US5899902A (en) * | 1997-07-03 | 1999-05-04 | Depuy Motech Acromed Corporation | Fastener |
US5916265A (en) * | 1994-03-30 | 1999-06-29 | Hu; Jie | Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant |
US5954723A (en) * | 1994-04-26 | 1999-09-21 | Spetzler; Robert F. | Method and apparatus for securing a cranial plate with pins |
US5981825A (en) * | 1994-05-13 | 1999-11-09 | Thm Biomedical, Inc. | Device and methods for in vivo culturing of diverse tissue cells |
US6027744A (en) * | 1998-04-24 | 2000-02-22 | University Of Massachusetts Medical Center | Guided development and support of hydrogel-cell compositions |
US6060640A (en) * | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
US6080194A (en) * | 1995-02-10 | 2000-06-27 | The Hospital For Joint Disease Orthopaedic Institute | Multi-stage collagen-based template or implant for use in the repair of cartilage lesions |
US6242247B1 (en) * | 1996-06-04 | 2001-06-05 | Sulzer Orthopedics Ltd. | Method for making cartilage and implants |
US6251143B1 (en) * | 1999-06-04 | 2001-06-26 | Depuy Orthopaedics, Inc. | Cartilage repair unit |
US6290711B1 (en) * | 1999-08-13 | 2001-09-18 | Innovasive Devices, Inc. | Connector device and method for surgically joining and securing flexible tissue repair members |
US6358284B1 (en) * | 1996-12-10 | 2002-03-19 | Med Institute, Inc. | Tubular grafts from purified submucosa |
US6383221B1 (en) * | 1999-01-22 | 2002-05-07 | Osteotech, Inc. | Method for forming an intervertebral implant |
US6409764B1 (en) * | 1998-12-03 | 2002-06-25 | Charles F. White | Methods and articles for regenerating bone or peridontal tissue |
US6517564B1 (en) * | 1999-02-02 | 2003-02-11 | Arthrex, Inc. | Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using same |
US6572650B1 (en) * | 1998-06-05 | 2003-06-03 | Organogenesis Inc. | Bioengineered vascular graft support prostheses |
US6692499B2 (en) * | 1997-07-02 | 2004-02-17 | Linvatec Biomaterials Oy | Surgical fastener for tissue treatment |
US7214242B2 (en) * | 1998-06-05 | 2007-05-08 | Organogenesis, Inc. | Bioengineered tubular graft prostheses |
Family Cites Families (224)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3272204A (en) * | 1965-09-22 | 1966-09-13 | Ethicon Inc | Absorbable collagen prosthetic implant with non-absorbable reinforcing strands |
GB1405886A (en) | 1971-11-01 | 1975-09-10 | Astra Laekemedel Ab | Synergistic compositions comprising penicillin and cephalosporin antibiotics |
US4060089A (en) * | 1975-09-03 | 1977-11-29 | United States Surgical Corporation | Surgical fastening method and device therefor |
US4208511A (en) | 1977-01-19 | 1980-06-17 | Ethicon, Inc. | Isomorphic copolyoxalates and sutures thereof |
US4141087A (en) * | 1977-01-19 | 1979-02-27 | Ethicon, Inc. | Isomorphic copolyoxalates and sutures thereof |
DE2722961C3 (en) * | 1977-05-18 | 1980-11-20 | Mannesmann Ag, 4000 Duesseldorf | Arrangement for fully automatic welding seam detection and tracking |
US4105034A (en) * | 1977-06-10 | 1978-08-08 | Ethicon, Inc. | Poly(alkylene oxalate) absorbable coating for sutures |
US4140678A (en) * | 1977-06-13 | 1979-02-20 | Ethicon, Inc. | Synthetic absorbable surgical devices of poly(alkylene oxalates) |
US4205399A (en) * | 1977-06-13 | 1980-06-03 | Ethicon, Inc. | Synthetic absorbable surgical devices of poly(alkylene oxalates) |
US4130639A (en) | 1977-09-28 | 1978-12-19 | Ethicon, Inc. | Absorbable pharmaceutical compositions based on isomorphic copolyoxalates |
FR2422386A1 (en) | 1978-04-13 | 1979-11-09 | Christian Buscayret | Device for fastening suture into tissue - has rectangular body with two perforations accommodating suture and two protuberances engaging tissue |
US4352463A (en) | 1979-01-18 | 1982-10-05 | Leisure Lawn, Inc. | Motorized combination wet and dry lawn treatment spreader |
US4400833A (en) | 1981-06-10 | 1983-08-30 | Kurland Kenneth Z | Means and method of implanting bioprosthetics |
US4418691A (en) | 1981-10-26 | 1983-12-06 | Massachusetts Institute Of Technology | Method of promoting the regeneration of tissue at a wound |
US4741330A (en) * | 1983-05-19 | 1988-05-03 | Hayhurst John O | Method and apparatus for anchoring and manipulating cartilage |
US4610397A (en) * | 1983-10-27 | 1986-09-09 | Urschel Laboratories Incorporated | Comminuting equipment |
US4873976A (en) | 1984-02-28 | 1989-10-17 | Schreiber Saul N | Surgical fasteners and method |
CA1295796C (en) | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
US4750492A (en) * | 1985-02-27 | 1988-06-14 | Richards Medical Company | Absorbable suture apparatus, method and installer |
US4669473A (en) * | 1985-09-06 | 1987-06-02 | Acufex Microsurgical, Inc. | Surgical fastener |
USRE34021E (en) * | 1985-11-18 | 1992-08-04 | Abbott Laboratories | Percutaneous fixation of hollow organs |
US4705040A (en) | 1985-11-18 | 1987-11-10 | Medi-Tech, Incorporated | Percutaneous fixation of hollow organs |
US5736372A (en) * | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
US4846835A (en) | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
US5681353A (en) | 1987-07-20 | 1997-10-28 | Regen Biologics, Inc. | Meniscal augmentation device |
US5306311A (en) | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
US4880429A (en) | 1987-07-20 | 1989-11-14 | Stone Kevin R | Prosthetic meniscus |
US5108438A (en) | 1989-03-02 | 1992-04-28 | Regen Corporation | Prosthetic intervertebral disc |
US5007934A (en) | 1987-07-20 | 1991-04-16 | Regen Corporation | Prosthetic meniscus |
US5350583A (en) | 1988-03-09 | 1994-09-27 | Terumo Kabushiki Kaisha | Cell-penetrable medical material and artificial skin |
GB2215209B (en) | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
US4956178A (en) | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
US5264214A (en) * | 1988-11-21 | 1993-11-23 | Collagen Corporation | Composition for bone repair |
US4919667A (en) | 1988-12-02 | 1990-04-24 | Stryker Corporation | Implant |
US5376118A (en) | 1989-05-10 | 1994-12-27 | United States Surgical Corporation | Support material for cell impregnation |
US5158573A (en) | 1989-06-09 | 1992-10-27 | American Medical Systems, Inc. | Injectable polymeric bodies |
US5061286A (en) | 1989-08-18 | 1991-10-29 | Osteotech, Inc. | Osteoprosthetic implant |
JPH03260178A (en) | 1990-03-06 | 1991-11-20 | Showa Shell Sekiyu Kk | Production of water-absorbing and water-retaining flexible cloth |
US5269809A (en) | 1990-07-02 | 1993-12-14 | American Cyanamid Company | Locking mechanism for use with a slotted suture anchor |
US5372146A (en) * | 1990-11-06 | 1994-12-13 | Branch; Thomas P. | Method and apparatus for re-approximating tissue |
US5258015A (en) | 1991-05-03 | 1993-11-02 | American Cyanamid Company | Locking filament caps |
US5269783A (en) | 1991-05-13 | 1993-12-14 | United States Surgical Corporation | Device and method for repairing torn tissue |
US5329846A (en) | 1991-08-12 | 1994-07-19 | Bonutti Peter M | Tissue press and system |
US5281422A (en) | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
US5676689A (en) * | 1991-11-08 | 1997-10-14 | Kensey Nash Corporation | Hemostatic puncture closure system including vessel location device and method of use |
ATE141493T1 (en) * | 1992-02-10 | 1996-09-15 | Matsumoto Dental College | BONE REPLACEMENT MATERIAL AND METHOD FOR PRODUCING IT |
ZA93506B (en) * | 1992-02-11 | 1994-05-11 | Bristol Myers Squibb Co | Soft tissue augmentation material |
US5571193A (en) * | 1992-03-12 | 1996-11-05 | Kampner; Stanley L. | Implant with reinforced resorbable stem |
US5326350A (en) * | 1992-05-11 | 1994-07-05 | Li Shu Tung | Soft tissue closure systems |
US5800537A (en) | 1992-08-07 | 1998-09-01 | Tissue Engineering, Inc. | Method and construct for producing graft tissue from an extracellular matrix |
US5383905A (en) | 1992-10-09 | 1995-01-24 | United States Surgical Corporation | Suture loop locking device |
US5352463A (en) * | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
US5641518A (en) * | 1992-11-13 | 1997-06-24 | Purdue Research Foundation | Method of repairing bone tissue |
US5275826A (en) * | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
US5320633A (en) | 1992-12-10 | 1994-06-14 | William C. Allen | Method and system for repairing a tear in the meniscus |
US5380334A (en) | 1993-02-17 | 1995-01-10 | Smith & Nephew Dyonics, Inc. | Soft tissue anchors and systems for implantation |
GB2280850B (en) | 1993-07-28 | 1997-07-30 | Johnson & Johnson Medical | Absorbable composite materials for use in the treatment of periodontal disease |
GB9306449D0 (en) * | 1993-03-29 | 1993-05-19 | Nat Heart Research Fund | Tissue equivalents |
US5500000A (en) | 1993-07-01 | 1996-03-19 | United States Surgical Corporation | Soft tissue repair system and method |
WO1995005083A1 (en) * | 1993-08-13 | 1995-02-23 | Smith & Nephew Richards Inc | Microporous polymeric foams and microtextured surfaces |
US5466262A (en) * | 1993-08-30 | 1995-11-14 | Saffran; Bruce N. | Malleable fracture stabilization device with micropores for directed drug delivery |
WO1995008354A1 (en) | 1993-09-24 | 1995-03-30 | Takiron Co., Ltd. | Implantation material |
GB2282328B (en) * | 1993-09-29 | 1997-10-08 | Johnson & Johnson Medical | Absorbable structures for ligament and tendon repair |
WO1995010989A1 (en) * | 1993-10-19 | 1995-04-27 | Scimed Life Systems, Inc. | Intravascular stent pump |
US5989280A (en) | 1993-10-22 | 1999-11-23 | Scimed Lifesystems, Inc | Stent delivery apparatus and method |
US5460962A (en) | 1994-01-04 | 1995-10-24 | Organogenesis Inc. | Peracetic acid sterilization of collagen or collagenous tissue |
US6334872B1 (en) | 1994-02-18 | 2002-01-01 | Organogenesis Inc. | Method for treating diseased or damaged organs |
US5773577A (en) * | 1994-03-03 | 1998-06-30 | Protein Polymer Technologies | Products comprising substrates capable of enzymatic cross-linking |
US5905997A (en) | 1994-04-29 | 1999-05-18 | Amd Inc. | Set-associative cache memory utilizing a single bank of physical memory |
CA2188563C (en) | 1994-04-29 | 2005-08-02 | Andrew W. Buirge | Stent with collagen |
JPH09512463A (en) | 1994-04-29 | 1997-12-16 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | Improved blood contact surface utilizing natural subendothelial matrix and method of making and using same |
US5545178A (en) * | 1994-04-29 | 1996-08-13 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
US5479033A (en) | 1994-05-27 | 1995-12-26 | Sandia Corporation | Complementary junction heterostructure field-effect transistor |
US5630824A (en) * | 1994-06-01 | 1997-05-20 | Innovasive Devices, Inc. | Suture attachment device |
US5632745A (en) | 1995-02-07 | 1997-05-27 | R&D Biologicals, Inc. | Surgical implantation of cartilage repair unit |
US5769899A (en) | 1994-08-12 | 1998-06-23 | Matrix Biotechnologies, Inc. | Cartilage repair unit |
US5569252A (en) | 1994-09-27 | 1996-10-29 | Justin; Daniel F. | Device for repairing a meniscal tear in a knee and method |
US6110212A (en) * | 1994-11-15 | 2000-08-29 | Kenton W. Gregory | Elastin and elastin-based materials |
US5891558A (en) * | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
US5709934A (en) * | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
JPH08162425A (en) | 1994-12-06 | 1996-06-21 | Mitsubishi Electric Corp | Manufacture and manufacturing method of semiconductor integrated circuit device |
US6235057B1 (en) | 1995-01-24 | 2001-05-22 | Smith & Nephew, Inc. | Method for soft tissue reconstruction |
US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
GB9721585D0 (en) * | 1997-10-10 | 1997-12-10 | Geistlich Soehne Ag | Chemical product |
GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
US5648088A (en) * | 1995-03-06 | 1997-07-15 | Ethicon, Inc. | Blends of absorbable polyoxaesters containing amines and/or amide groups |
US5698213A (en) | 1995-03-06 | 1997-12-16 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters |
US5700583A (en) | 1995-03-06 | 1997-12-23 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters containing amines or amido groups |
US5595751A (en) * | 1995-03-06 | 1997-01-21 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/or amido groups |
US5607687A (en) * | 1995-03-06 | 1997-03-04 | Ethicon, Inc. | Polymer blends containing absorbable polyoxaesters |
US5618552A (en) | 1995-03-06 | 1997-04-08 | Ethicon, Inc. | Absorbable polyoxaesters |
US5464929A (en) | 1995-03-06 | 1995-11-07 | Ethicon, Inc. | Absorbable polyoxaesters |
US5597579A (en) | 1995-03-06 | 1997-01-28 | Ethicon, Inc. | Blends of absorbable polyoxaamides |
US5859150A (en) * | 1995-03-06 | 1999-01-12 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters |
US5782835A (en) | 1995-03-07 | 1998-07-21 | Innovasive Devices, Inc. | Apparatus and methods for articular cartilage defect repair |
CA2173508A1 (en) | 1995-03-31 | 1996-10-01 | Tooru Yui | Medical device and method for producing the same |
US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
DE69622548T2 (en) * | 1995-04-07 | 2003-09-18 | Purdue Research Foundation West Lafayette | TISSUE TRANSPLANT FOR BUBBLE RECONSTRUCTION |
US5711969A (en) | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
US5733337A (en) | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
US6123727A (en) * | 1995-05-01 | 2000-09-26 | Massachusetts Institute Of Technology | Tissue engineered tendons and ligaments |
US5855610A (en) * | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
JP3689146B2 (en) * | 1995-05-30 | 2005-08-31 | ペンタックス株式会社 | Elements for screw fixation to bone |
US5965125A (en) * | 1995-10-25 | 1999-10-12 | Transkaryotic Therapies, Inc. | Hybrid matrix implants and explants |
AU7274696A (en) | 1995-11-06 | 1997-05-29 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
US5843084A (en) * | 1995-11-17 | 1998-12-01 | Innovasive Devices, Inc. | Surgical fastening system and method for using the same |
US5981802A (en) | 1995-12-14 | 1999-11-09 | The Trustees Of Columbia University In The City Of New York | Simple allylic amination procedure |
US5725556A (en) * | 1995-12-15 | 1998-03-10 | M & R Medical, Inc. | Suture locking apparatus |
US5626614A (en) * | 1995-12-22 | 1997-05-06 | Applied Medical Resources Corporation | T-anchor suturing device and method for using same |
US5702462A (en) | 1996-01-24 | 1997-12-30 | Oberlander; Michael | Method of meniscal repair |
US5759208A (en) | 1996-02-29 | 1998-06-02 | The Procter & Gamble Company | Laundry detergent compositions containing silicone emulsions |
US5755791A (en) | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
US5788625A (en) | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
US5730933A (en) | 1996-04-16 | 1998-03-24 | Depuy Orthopaedics, Inc. | Radiation sterilization of biologically active compounds |
US6299905B1 (en) * | 1996-04-16 | 2001-10-09 | Depuy Orthopaedics, Inc. | Bioerodable polymeric adhesives for tissue repair |
US5668288A (en) | 1996-04-16 | 1997-09-16 | Depuy Orthopaedics, Inc. | Polyester ionomers for implant fabrication |
US5733868A (en) | 1996-04-16 | 1998-03-31 | Depuy Orthopaedics, Inc. | Poly(amino acid) adhesive tissue grafts |
US5834232A (en) | 1996-05-01 | 1998-11-10 | Zymogenetics, Inc. | Cross-linked gelatin gels and methods of making them |
EP0907721A1 (en) * | 1996-05-28 | 1999-04-14 | Brown University Research Foundation | Hyaluronan based biodegradable scaffolds for tissue repair |
AU2759397A (en) * | 1996-05-28 | 1998-01-05 | 1218122 Ontario Inc. | Resorbable implant biomaterial made of condensed calcium phosphate particles |
IT1288290B1 (en) | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | SELF-LETICULATED HYALURONIC ACID AND RELATED PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ARTHROPATHIES |
JP2000513457A (en) * | 1996-06-24 | 2000-10-10 | ヴァン コーベリング カンパニー | Musical instrument system |
US6171344B1 (en) | 1996-08-16 | 2001-01-09 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
US6280473B1 (en) * | 1996-08-19 | 2001-08-28 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
US6666892B2 (en) | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
AU742457B2 (en) | 1996-08-23 | 2002-01-03 | Cook Biotech, Incorporated | Graft prosthesis, materials and methods |
US5759190A (en) | 1996-08-30 | 1998-06-02 | Vts Holdings Limited | Method and kit for autologous transplantation |
US5989269A (en) | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
US20020173806A1 (en) | 1996-08-30 | 2002-11-21 | Verigen Transplantation Service International (Vtsi) Ag | Method for autologous transplantation |
US5863551A (en) * | 1996-10-16 | 1999-01-26 | Organogel Canada Ltee | Implantable polymer hydrogel for therapeutic uses |
CA2267449C (en) | 1996-11-05 | 2008-10-14 | Purdue Research Foundation | Myocardial graft constructs |
AU7178698A (en) | 1996-11-15 | 1998-06-03 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
DK1671604T3 (en) | 1996-12-10 | 2009-11-09 | Purdue Research Foundation | Synthetic tissue valve |
JP4302188B2 (en) | 1996-12-10 | 2009-07-22 | パーデュー・リサーチ・ファウンデーション | Gastric submucosa-derived tissue graft |
AU732726B2 (en) | 1996-12-10 | 2001-04-26 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
CA2224366C (en) | 1996-12-11 | 2006-10-31 | Ethicon, Inc. | Meniscal repair device |
US6083522A (en) * | 1997-01-09 | 2000-07-04 | Neucoll, Inc. | Devices for tissue repair and methods for preparation and use thereof |
US6146385A (en) | 1997-02-11 | 2000-11-14 | Smith & Nephew, Inc. | Repairing cartilage |
GB9704288D0 (en) | 1997-03-01 | 1997-04-23 | Smith & Nephew | Hydrogels |
US6120539A (en) * | 1997-05-01 | 2000-09-19 | C. R. Bard Inc. | Prosthetic repair fabric |
US5993844A (en) | 1997-05-08 | 1999-11-30 | Organogenesis, Inc. | Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix |
US5980524A (en) | 1997-06-02 | 1999-11-09 | Innovasive Devices, Inc. | Device for repairing a meniscal tear in a knee and method |
US5906997A (en) | 1997-06-17 | 1999-05-25 | Fzio Med, Inc. | Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions |
US6869938B1 (en) * | 1997-06-17 | 2005-03-22 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use in reducing adhesions |
FR2766717B1 (en) | 1997-08-01 | 2000-06-09 | Cogent Sarl | COMPOSITE PROSTHESIS FOR PREVENTION OF POST-SURGICAL ADHESIONS AND PROCESS FOR OBTAINING SAME |
FR2766716B1 (en) * | 1997-08-01 | 2000-02-18 | Cogent Sarl | COMPOSITE PROSTHESIS FOR PREVENTION OF POST-SURGICAL ADHESIONS AND PROCESS FOR OBTAINING SAME |
US6010525A (en) * | 1997-08-01 | 2000-01-04 | Peter M. Bonutti | Method and apparatus for securing a suture |
US20010031254A1 (en) * | 1998-11-13 | 2001-10-18 | Bianchi John R. | Assembled implant |
AUPP000797A0 (en) | 1997-10-24 | 1997-11-20 | Cryptych Pty Ltd | Fixation of cruciate ligament grafts |
US6056778A (en) | 1997-10-29 | 2000-05-02 | Arthrex, Inc. | Meniscal repair device |
US6438110B1 (en) * | 1997-11-12 | 2002-08-20 | Nortel Networks Limited | Reservation of connections in a communications network |
US5954747A (en) | 1997-11-20 | 1999-09-21 | Clark; Ron | Meniscus repair anchor system |
US6214049B1 (en) | 1999-01-14 | 2001-04-10 | Comfort Biomedical, Inc. | Method and apparatus for augmentating osteointegration of prosthetic implant devices |
JP3981525B2 (en) * | 1998-01-20 | 2007-09-26 | ハワード・グリーン | Transglutaminase linkage of substances to tissues |
US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US6068648A (en) | 1998-01-26 | 2000-05-30 | Orthodyne, Inc. | Tissue anchoring system and method |
US6123731A (en) | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
US5958874A (en) | 1998-02-18 | 1999-09-28 | The Research Foundation Of State University Of New York | Recombinant fibronectin-based extracellular matrix for wound healing |
US6056777A (en) | 1998-02-27 | 2000-05-02 | Mcdowell; Charles L. | Method and device for regenerating cartilage in articulating |
US6179872B1 (en) * | 1998-03-17 | 2001-01-30 | Tissue Engineering | Biopolymer matt for use in tissue repair and reconstruction |
US5993475A (en) | 1998-04-22 | 1999-11-30 | Bristol-Myers Squibb Co. | Tissue repair device |
JPH11319068A (en) | 1998-05-12 | 1999-11-24 | Menicon Co Ltd | Base material for artificial skin and production thereof |
US6265333B1 (en) * | 1998-06-02 | 2001-07-24 | Board Of Regents, University Of Nebraska-Lincoln | Delamination resistant composites prepared by small diameter fiber reinforcement at ply interfaces |
US5971987A (en) | 1998-09-18 | 1999-10-26 | Ethicon, Inc. | Biocompatible absorbable polymer fastener and driver for use in surgical procedures |
JP2002528567A (en) | 1998-10-28 | 2002-09-03 | アシュビー・サイエンティフィック・リミテッド | Porous silicone rubber woven |
US6066160A (en) * | 1998-11-23 | 2000-05-23 | Quickie Llc | Passive knotless suture terminator for use in minimally invasive surgery and to facilitate standard tissue securing |
US20020165611A1 (en) | 1998-12-22 | 2002-11-07 | Robert-Jan Enzerink | Graft material convenience package |
US6306159B1 (en) | 1998-12-23 | 2001-10-23 | Depuy Orthopaedics, Inc. | Meniscal repair device |
EP1016377B1 (en) | 1998-12-30 | 2006-04-26 | Ethicon Inc. | Suture locking device |
US6326025B1 (en) | 1998-12-30 | 2001-12-04 | Depuy Orthopaedics, Inc | Tissue reactive adhesive compositions |
US6200347B1 (en) | 1999-01-05 | 2001-03-13 | Lifenet | Composite bone graft, method of making and using same |
US6093201A (en) | 1999-01-19 | 2000-07-25 | Ethicon, Inc. | Biocompatible absorbable polymer plating system for tissue fixation |
US6294187B1 (en) * | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US20020090725A1 (en) * | 2000-11-17 | 2002-07-11 | Simpson David G. | Electroprocessed collagen |
US6592623B1 (en) * | 1999-08-31 | 2003-07-15 | Virginia Commonwealth University Intellectual Property Foundation | Engineered muscle |
AU6406700A (en) * | 1999-03-16 | 2000-10-04 | Regeneration Technologies, Inc. | Molded implants for orthopedic applications |
US6258124B1 (en) * | 1999-05-10 | 2001-07-10 | C. R. Bard, Inc. | Prosthetic repair fabric |
US6288043B1 (en) | 1999-06-18 | 2001-09-11 | Orquest, Inc. | Injectable hyaluronate-sulfated polysaccharide conjugates |
US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
US6652872B2 (en) | 1999-07-06 | 2003-11-25 | Ramat At Tel Aviv University Ltd. | Scaffold formed of tissue treated to eliminate cellular and cytosolic elements |
US6423073B2 (en) * | 1999-07-23 | 2002-07-23 | Ethicon, Inc. | Instrument for inserting graft fixation device |
US6436110B2 (en) | 1999-07-23 | 2002-08-20 | Ethicon, Inc. | Method of securing a graft using a graft fixation device |
US6179840B1 (en) | 1999-07-23 | 2001-01-30 | Ethicon, Inc. | Graft fixation device and method |
US20020095157A1 (en) * | 1999-07-23 | 2002-07-18 | Bowman Steven M. | Graft fixation device combination |
US6447517B1 (en) | 1999-07-23 | 2002-09-10 | Ethicon, Inc. | Instrument for inserting graft fixation device |
US6402766B2 (en) * | 1999-07-23 | 2002-06-11 | Ethicon, Inc. | Graft fixation device combination |
US20020052628A1 (en) | 1999-07-23 | 2002-05-02 | Bowman Steven M. | Graft fixation device and method |
US7214232B2 (en) | 1999-07-23 | 2007-05-08 | Ethicon, Inc. | Graft fixation device |
US6364884B1 (en) | 1999-07-23 | 2002-04-02 | Ethicon, Inc. | Method of securing a graft using a graft fixation device |
US6497707B1 (en) | 1999-07-23 | 2002-12-24 | Ethicon, Inc. | Graft fixation device combination |
ES2234642T3 (en) | 1999-07-28 | 2005-07-01 | Davol Inc | PROTESIS FOR HERNIAS. |
US6319258B1 (en) | 1999-09-29 | 2001-11-20 | Ethicon, Inc. | Absorbable rivet/pin applier for use in surgical procedures |
US6273893B1 (en) | 1999-11-10 | 2001-08-14 | Ethicon, Inc. | Absorbable rivet/pin applier for use in surgical procedures |
US7153312B1 (en) | 1999-12-02 | 2006-12-26 | Smith & Nephew Inc. | Closure device and method for tissue repair |
EP1233707B1 (en) | 1999-12-03 | 2007-08-08 | The University Of Leeds | Repair of damaged tissue |
US6566345B2 (en) | 2000-04-28 | 2003-05-20 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
JP2001185930A (en) * | 1999-12-27 | 2001-07-06 | Toyota Autom Loom Works Ltd | Radio communication device of paddle for feeding |
US6508821B1 (en) * | 2000-01-28 | 2003-01-21 | Depuy Orthopaedics, Inc. | Soft tissue repair material fixation apparatus and method |
US6371958B1 (en) | 2000-03-02 | 2002-04-16 | Ethicon, Inc. | Scaffold fixation device for use in articular cartilage repair |
AU2001261595A1 (en) | 2000-05-22 | 2001-12-03 | Arthur C. Coffey | Combination sis and vacuum bandage and method |
US6638312B2 (en) * | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US6812221B2 (en) | 2000-11-21 | 2004-11-02 | The Texas A&M University System | FGF-affinity chromatography |
US6851250B2 (en) * | 2000-11-29 | 2005-02-08 | Premark Feg L.L.C. | Package wrapping machine with automatic package positioning prior to wrapping |
US6566645B1 (en) * | 2000-12-19 | 2003-05-20 | James D. Murphey | Remote system trigger circuit |
US6306140B1 (en) * | 2001-01-17 | 2001-10-23 | Synthes (Usa) | Bone screw |
JP4426285B2 (en) * | 2001-06-28 | 2010-03-03 | クック・バイオテック・インコーポレーテッド | Graft prosthesis device containing renal capsule collagen |
US8025896B2 (en) * | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US7361195B2 (en) * | 2001-07-16 | 2008-04-22 | Depuy Products, Inc. | Cartilage repair apparatus and method |
EP1416879A4 (en) * | 2001-07-16 | 2007-04-25 | Depuy Products Inc | Unitary surgical device and method |
US7914808B2 (en) * | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
AU2002322567B2 (en) * | 2001-07-16 | 2007-09-06 | Depuy Products, Inc. | Devices form naturally occurring biologically derived |
WO2003007787A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Cartilage repair and regeneration device and method |
WO2003007786A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Porous delivery scaffold and method |
EP1416888A4 (en) * | 2001-07-16 | 2007-04-25 | Depuy Products Inc | Meniscus regeneration device and method |
US6989034B2 (en) | 2002-05-31 | 2006-01-24 | Ethicon, Inc. | Attachment of absorbable tissue scaffolds to fixation devices |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US7569233B2 (en) | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
EP1593400A1 (en) | 2004-05-04 | 2005-11-09 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050249772A1 (en) | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
-
2002
- 2002-07-15 AU AU2002322567A patent/AU2002322567B2/en not_active Ceased
- 2002-07-15 JP JP2003513448A patent/JP4197158B2/en not_active Expired - Fee Related
- 2002-07-15 WO PCT/US2002/023189 patent/WO2003007839A2/en active Application Filing
- 2002-07-15 US US10/195,719 patent/US20030032961A1/en not_active Abandoned
- 2002-07-15 US US10/483,465 patent/US8337537B2/en active Active
- 2002-07-15 EP EP02756565A patent/EP1416866A4/en not_active Withdrawn
Patent Citations (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3562820A (en) * | 1966-08-22 | 1971-02-16 | Bernhard Braun | Tubular sheet and strip form prostheses on a basis of biological tissue |
US4642120A (en) * | 1983-03-23 | 1987-02-10 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Repair of cartilage and bones |
US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
US4976715A (en) * | 1986-05-20 | 1990-12-11 | Concept, Inc. | Repair tack for bodily tissue |
US5246441A (en) * | 1989-09-08 | 1993-09-21 | Linvatec Corporation | Bioabsorbable tack for joining bodily tissue |
US5102421A (en) * | 1990-06-14 | 1992-04-07 | Wm. E. Anpach, III | Suture anchor and method of forming |
US5236431A (en) * | 1991-07-22 | 1993-08-17 | Synthes | Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor |
US5593441A (en) * | 1992-03-04 | 1997-01-14 | C. R. Bard, Inc. | Method for limiting the incidence of postoperative adhesions |
US5591234A (en) * | 1993-02-01 | 1997-01-07 | Axel Kirsch | Post-surgery orthopedic covering |
US5759205A (en) * | 1994-01-21 | 1998-06-02 | Brown University Research Foundation | Negatively charged polymeric electret implant |
US5916265A (en) * | 1994-03-30 | 1999-06-29 | Hu; Jie | Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant |
US5954723A (en) * | 1994-04-26 | 1999-09-21 | Spetzler; Robert F. | Method and apparatus for securing a cranial plate with pins |
US5669912A (en) * | 1994-04-26 | 1997-09-23 | Spetzler; Robert F. | Apparatus for securing a cranial piece in position |
US5795353A (en) * | 1994-05-06 | 1998-08-18 | Advanced Bio Surfaces, Inc. | Joint resurfacing system |
US5981825A (en) * | 1994-05-13 | 1999-11-09 | Thm Biomedical, Inc. | Device and methods for in vivo culturing of diverse tissue cells |
US5855619A (en) * | 1994-06-06 | 1999-01-05 | Case Western Reserve University | Biomatrix for soft tissue regeneration |
US6080194A (en) * | 1995-02-10 | 2000-06-27 | The Hospital For Joint Disease Orthopaedic Institute | Multi-stage collagen-based template or implant for use in the repair of cartilage lesions |
US6060640A (en) * | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
US5830708A (en) * | 1995-06-06 | 1998-11-03 | Advanced Tissue Sciences, Inc. | Methods for production of a naturally secreted extracellular matrix |
US5855613A (en) * | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
US5842477A (en) * | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
US6242247B1 (en) * | 1996-06-04 | 2001-06-05 | Sulzer Orthopedics Ltd. | Method for making cartilage and implants |
US6358284B1 (en) * | 1996-12-10 | 2002-03-19 | Med Institute, Inc. | Tubular grafts from purified submucosa |
US6692499B2 (en) * | 1997-07-02 | 2004-02-17 | Linvatec Biomaterials Oy | Surgical fastener for tissue treatment |
US5899902A (en) * | 1997-07-03 | 1999-05-04 | Depuy Motech Acromed Corporation | Fastener |
US6027744A (en) * | 1998-04-24 | 2000-02-22 | University Of Massachusetts Medical Center | Guided development and support of hydrogel-cell compositions |
US6572650B1 (en) * | 1998-06-05 | 2003-06-03 | Organogenesis Inc. | Bioengineered vascular graft support prostheses |
US7214242B2 (en) * | 1998-06-05 | 2007-05-08 | Organogenesis, Inc. | Bioengineered tubular graft prostheses |
US6409764B1 (en) * | 1998-12-03 | 2002-06-25 | Charles F. White | Methods and articles for regenerating bone or peridontal tissue |
US6383221B1 (en) * | 1999-01-22 | 2002-05-07 | Osteotech, Inc. | Method for forming an intervertebral implant |
US6517564B1 (en) * | 1999-02-02 | 2003-02-11 | Arthrex, Inc. | Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using same |
US6251143B1 (en) * | 1999-06-04 | 2001-06-26 | Depuy Orthopaedics, Inc. | Cartilage repair unit |
US6290711B1 (en) * | 1999-08-13 | 2001-09-18 | Innovasive Devices, Inc. | Connector device and method for surgically joining and securing flexible tissue repair members |
Cited By (454)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070288027A1 (en) * | 1999-02-02 | 2007-12-13 | Grafton R D | Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using the same |
US7211088B2 (en) * | 1999-02-02 | 2007-05-01 | Arthrex, Inc. | Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using the same |
US20040098045A1 (en) * | 1999-02-02 | 2004-05-20 | Grafton R. Donald | Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using the same |
US20070129811A1 (en) * | 2000-08-04 | 2007-06-07 | Plouhar Pamela L | Reinforced small intestinal submucosa |
US20030023316A1 (en) * | 2000-08-04 | 2003-01-30 | Brown Laura Jean | Hybrid biologic-synthetic bioabsorable scaffolds |
US20040059431A1 (en) * | 2000-08-04 | 2004-03-25 | Plouhar Pamela L. | Reinforced small intestinal submucosa |
US7799089B2 (en) | 2000-08-04 | 2010-09-21 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa |
US8366787B2 (en) | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050149187A1 (en) * | 2000-08-28 | 2005-07-07 | Ron Clark | Method and implant for securing ligament replacement into the knee |
US7837718B2 (en) | 2000-08-28 | 2010-11-23 | Biomet Sports Medicine, Llc | Method and implant for securing ligament replacement into the knee |
US20080167667A1 (en) * | 2000-10-23 | 2008-07-10 | Criscuolo Christopher J | Absorbable fastener and applying apparatus |
US8114101B2 (en) | 2000-10-23 | 2012-02-14 | Tyco Healthcare Group Lp | Absorbable fastener and applying apparatus |
US8728102B2 (en) | 2000-10-23 | 2014-05-20 | Covidien Lp | Absorbable fastener and applying apparatus |
US8597311B2 (en) | 2000-10-23 | 2013-12-03 | Covidien Lp | Absorbable fastener and applying apparatus |
US20080167668A1 (en) * | 2000-10-23 | 2008-07-10 | Criscuolo Christopher J | Absorbable fastener and applying apparatus |
US20040092937A1 (en) * | 2000-10-23 | 2004-05-13 | Criscuolo Christopher J. | Absorbable fastener and applying apparatus |
US8034076B2 (en) | 2000-10-23 | 2011-10-11 | Tyco Healthcare Group Lp | Absorbable fastener and applying apparatus |
US8092529B2 (en) | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
US20050027307A1 (en) * | 2001-07-16 | 2005-02-03 | Schwartz Herbert Eugene | Unitary surgical device and method |
US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
US20030033021A1 (en) * | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration scaffold and method |
US7914808B2 (en) | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US20030033022A1 (en) * | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration device and method |
US8012205B2 (en) * | 2001-07-16 | 2011-09-06 | Depuy Products, Inc. | Cartilage repair and regeneration device |
AU2002354915B8 (en) * | 2001-07-16 | 2008-04-17 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US8025896B2 (en) * | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US20040220574A1 (en) * | 2001-07-16 | 2004-11-04 | Pelo Mark Joseph | Device from naturally occuring biologically derived materials |
US20040143344A1 (en) * | 2001-07-16 | 2004-07-22 | Prasanna Malaviya | Implantable tissue repair device and method |
US8337537B2 (en) | 2001-07-16 | 2012-12-25 | Depuy Products, Inc. | Device from naturally occurring biologically derived materials |
AU2002354915B2 (en) * | 2001-07-16 | 2008-03-20 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US20030036797A1 (en) * | 2001-07-16 | 2003-02-20 | Prasanna Malaviya | Meniscus regeneration device and method |
US20030044444A1 (en) * | 2001-07-16 | 2003-03-06 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20030078617A1 (en) * | 2001-07-16 | 2003-04-24 | Schwartz Herbert E. | Unitary surgical device and method |
US20050090139A1 (en) * | 2002-03-28 | 2005-04-28 | Rowland White | Contact |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20090248144A1 (en) * | 2002-08-20 | 2009-10-01 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
US7887576B2 (en) | 2002-08-20 | 2011-02-15 | Cook Incorporated | Endoluminal device with extracellular matrix material and methods |
US20050273155A1 (en) * | 2002-08-20 | 2005-12-08 | Bahler Clinton D | Endoluminal device with extracellular matrix material and methods |
US7550004B2 (en) | 2002-08-20 | 2009-06-23 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
US20040181230A1 (en) * | 2003-03-13 | 2004-09-16 | Rizzo Rosario | Micronail and method for dental use |
US20060263335A1 (en) * | 2003-03-27 | 2006-11-23 | Regentec Ltd. | Porous matrix |
US9486558B2 (en) | 2003-03-27 | 2016-11-08 | Locate Therapeutics Limited | Porous matrix |
US10232087B2 (en) | 2003-03-27 | 2019-03-19 | Locate Therapeutics Limited | Porous matrix |
US8562542B2 (en) | 2003-03-28 | 2013-10-22 | Depuy Mitek, Llc | Tissue collection device and methods |
US20100280406A1 (en) * | 2003-03-28 | 2010-11-04 | Ethicon, Inc. | Tissue Collection Device and Methods |
USRE43258E1 (en) | 2003-04-29 | 2012-03-20 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US20080274157A1 (en) * | 2003-04-29 | 2008-11-06 | Gordana Vunjak-Novakovic | Cartilage implant plug with fibrin glue and method for implantation |
US20080133008A1 (en) * | 2003-04-29 | 2008-06-05 | Muscuoskeletal Transplant Foundation | Cartilage repair mixture containing allograft chondrocytes |
USRE42208E1 (en) | 2003-04-29 | 2011-03-08 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US20060210643A1 (en) * | 2003-04-29 | 2006-09-21 | Truncale Katherine A G | Cartilage repair mixture containing allograft chondrocytes |
US8221500B2 (en) | 2003-05-16 | 2012-07-17 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20090291112A1 (en) * | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
US20040230303A1 (en) * | 2003-05-16 | 2004-11-18 | Gomes Katherine A. | Cartilage allograft plug |
US20050251268A1 (en) * | 2003-05-16 | 2005-11-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20080234715A1 (en) * | 2003-09-11 | 2008-09-25 | Depuy Mitek, Inc. | Tissue Extraction and Collection Device |
US8585610B2 (en) | 2003-09-11 | 2013-11-19 | Depuy Mitek, Llc | Tissue extraction and maceration device |
US7998086B2 (en) | 2003-09-11 | 2011-08-16 | Depuy Mitek, Inc. | Tissue extraction and maceration device |
US20050059905A1 (en) * | 2003-09-11 | 2005-03-17 | Robert Boock | Tissue extraction and maceration device |
US8034003B2 (en) | 2003-09-11 | 2011-10-11 | Depuy Mitek, Inc. | Tissue extraction and collection device |
US20100022915A1 (en) * | 2003-09-11 | 2010-01-28 | Depuy Mitek, Inc. | Tissue extraction and maceration device |
US8870788B2 (en) | 2003-09-11 | 2014-10-28 | Depuy Mitek, Llc | Tissue extraction and collection device |
US7896917B2 (en) | 2003-10-15 | 2011-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for graft fixation |
US8784489B2 (en) | 2003-10-15 | 2014-07-22 | Biomet Sports Medicine, Llc | Method and apparatus for graft fixation |
US20110153018A1 (en) * | 2003-10-15 | 2011-06-23 | Biomet Sports Medicine, Llc | Method and Apparatus for Graft Fixation |
US20050273003A1 (en) * | 2003-10-15 | 2005-12-08 | Arthrotek, Inc. | Method and apparatus for graft fixation |
US20050136764A1 (en) * | 2003-12-18 | 2005-06-23 | Sherman Michael C. | Designed composite degradation for spinal implants |
US20060058799A1 (en) * | 2004-02-10 | 2006-03-16 | Robert Elson | Ligament repair apparatus and method |
US8221454B2 (en) | 2004-02-20 | 2012-07-17 | Biomet Sports Medicine, Llc | Apparatus for performing meniscus repair |
US20050222687A1 (en) * | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
US20090043389A1 (en) * | 2004-04-02 | 2009-02-12 | Gordana Vunjak-Novakovic | Cartilage implant plug with fibrin glue and method for implantation |
JP2005305162A (en) * | 2004-04-20 | 2005-11-04 | Depuy Mitek Inc | Meniscus repair scaffold |
JP4549919B2 (en) * | 2004-04-20 | 2010-09-22 | デピュイ・ミテック・インコーポレイテッド | Meniscal repair scaffold |
US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US20050249771A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US8002778B1 (en) | 2004-06-28 | 2011-08-23 | Biomet Sports Medicine, Llc | Crosspin and method for inserting the same during soft ligament repair |
US8840651B2 (en) | 2004-08-09 | 2014-09-23 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US9949843B2 (en) | 2004-08-09 | 2018-04-24 | Si-Bone Inc. | Apparatus, systems, and methods for the fixation or fusion of bone |
US9486264B2 (en) | 2004-08-09 | 2016-11-08 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone using compressive implants |
US9492201B2 (en) | 2004-08-09 | 2016-11-15 | Si-Bone Inc. | Apparatus, systems and methods for achieving anterior lumbar interbody fusion |
US8414648B2 (en) | 2004-08-09 | 2013-04-09 | Si-Bone Inc. | Apparatus, systems, and methods for achieving trans-iliac lumbar fusion |
US9561063B2 (en) * | 2004-08-09 | 2017-02-07 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US20100292738A1 (en) * | 2004-08-09 | 2010-11-18 | Inbone Technologies, Inc. | Systems and methods for the fixation or fusion of bone |
US8425570B2 (en) | 2004-08-09 | 2013-04-23 | Si-Bone Inc. | Apparatus, systems, and methods for achieving anterior lumbar interbody fusion |
US9375323B2 (en) | 2004-08-09 | 2016-06-28 | Si-Bone Inc. | Apparatus, systems, and methods for achieving trans-iliac lumbar fusion |
US8444693B2 (en) * | 2004-08-09 | 2013-05-21 | Si-Bone Inc. | Apparatus, systems, and methods for achieving lumbar facet fusion |
US8308779B2 (en) | 2004-08-09 | 2012-11-13 | Si-Bone, Inc. | Systems and methods for the fixation or fusion of bone |
US9039743B2 (en) | 2004-08-09 | 2015-05-26 | Si-Bone Inc. | Systems and methods for the fusion of the sacral-iliac joint |
US8470004B2 (en) | 2004-08-09 | 2013-06-25 | Si-Bone Inc. | Apparatus, systems, and methods for stabilizing a spondylolisthesis |
US20090259261A1 (en) * | 2004-08-09 | 2009-10-15 | Mark A Reiley | Systems and methods for the fixation or fusion of bone at or near a sacroiliac joint |
US9622783B2 (en) | 2004-08-09 | 2017-04-18 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US9662158B2 (en) * | 2004-08-09 | 2017-05-30 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone at or near a sacroiliac joint |
US20130184769A1 (en) * | 2004-08-09 | 2013-07-18 | Mark A. Reiley | Systems and methods for the fixation or fusion of bone using compressive implants |
US8986348B2 (en) | 2004-08-09 | 2015-03-24 | Si-Bone Inc. | Systems and methods for the fusion of the sacral-iliac joint |
US8920477B2 (en) * | 2004-08-09 | 2014-12-30 | Si-Bone Inc. | Apparatus, systems, and methods for stabilizing a spondylolisthesis |
US9662128B2 (en) | 2004-08-09 | 2017-05-30 | Si-Bone Inc. | Systems and methods for the fusion of the sacral-iliac joint |
US9675394B2 (en) | 2004-08-09 | 2017-06-13 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone at or near a sacroiliac joint |
US8202305B2 (en) * | 2004-08-09 | 2012-06-19 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US20110087296A1 (en) * | 2004-08-09 | 2011-04-14 | Si-Bone, Inc. | Systems and methods for the fixation of fusion of bone using compressive implants |
US20110118841A1 (en) * | 2004-08-09 | 2011-05-19 | Si-Bone, Inc. | Apparatus, systems, and methods for achieving trans-iliac lumbar fusion |
US20110118796A1 (en) * | 2004-08-09 | 2011-05-19 | Reiley Mark A | Systems and methods for the fixation or fusion of bone |
US20110125268A1 (en) * | 2004-08-09 | 2011-05-26 | Si-Bone, Inc. | Apparatus, systems, and methods for achieving lumbar facet fusion |
US8858601B2 (en) * | 2004-08-09 | 2014-10-14 | Si-Bone Inc. | Apparatus, systems, and methods for achieving lumbar facet fusion |
US9743969B2 (en) | 2004-08-09 | 2017-08-29 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US20110184478A1 (en) * | 2004-08-09 | 2011-07-28 | Si-Bone, Inc. | Systems and methods for the fixation or fusion of bone |
US8388667B2 (en) * | 2004-08-09 | 2013-03-05 | Si-Bone, Inc. | Systems and methods for the fixation or fusion of bone using compressive implants |
US8840623B2 (en) | 2004-08-09 | 2014-09-23 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US20080154316A1 (en) * | 2004-08-09 | 2008-06-26 | Inbone Technologies, Inc. | Systems and methods for the fixation or fusion bone related applications |
US8734462B2 (en) * | 2004-08-09 | 2014-05-27 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone using compressive implants |
US9820789B2 (en) | 2004-08-09 | 2017-11-21 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US10004547B2 (en) | 2004-08-09 | 2018-06-26 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone at or near a sacroiliac joint |
US9956013B2 (en) | 2004-08-09 | 2018-05-01 | Si-Bone Inc. | Systems and methods for the fixation or fusion of bone |
US20060041261A1 (en) * | 2004-08-17 | 2006-02-23 | Osypka Thomas P | Apparatus and method for attaching connective tissue to bone |
US20090319045A1 (en) * | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US8292968B2 (en) | 2004-10-12 | 2012-10-23 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US7857851B2 (en) | 2004-10-29 | 2010-12-28 | Depuy Products, Inc. | Implant system with sizing templates |
US20060211953A1 (en) * | 2004-10-29 | 2006-09-21 | Zannis Anthony D | Coordinate instrument set |
US9113954B2 (en) | 2004-10-29 | 2015-08-25 | DePuy Synthes Products, Inc. | Coordinate instrument set |
US20060128296A1 (en) * | 2004-10-29 | 2006-06-15 | Schwan Wade E | Intestine processing device and associated method |
EP1652484A1 (en) | 2004-10-29 | 2006-05-03 | DePuy Products, Inc. | Instruments, kit and method for suture managment |
US7785332B2 (en) | 2004-10-29 | 2010-08-31 | Depuy Products, Inc. | Method of delivering therapeutic implant |
EP1652473A1 (en) | 2004-10-29 | 2006-05-03 | DePuy Products, Inc. | Implant system with sizing templates |
US8574238B2 (en) * | 2004-10-29 | 2013-11-05 | Depuy Mitek, Llc | Instruments, kit and method for suture management |
US20060095053A1 (en) * | 2004-10-29 | 2006-05-04 | Zannis Anthony D | Method of delivering therapeutic implant |
US20060095054A1 (en) * | 2004-10-29 | 2006-05-04 | Zannis Anthony D | Instruments, kit and method for suture management |
US8128658B2 (en) | 2004-11-05 | 2012-03-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US8118836B2 (en) | 2004-11-05 | 2012-02-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8840645B2 (en) | 2004-11-05 | 2014-09-23 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US11109857B2 (en) | 2004-11-05 | 2021-09-07 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US9801708B2 (en) | 2004-11-05 | 2017-10-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US20060190042A1 (en) * | 2004-11-05 | 2006-08-24 | Arthrotek, Inc. | Tissue repair assembly |
US8551140B2 (en) | 2004-11-05 | 2013-10-08 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US9504460B2 (en) | 2004-11-05 | 2016-11-29 | Biomet Sports Medicine, LLC. | Soft tissue repair device and method |
US8137382B2 (en) | 2004-11-05 | 2012-03-20 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US9572655B2 (en) | 2004-11-05 | 2017-02-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8303604B2 (en) | 2004-11-05 | 2012-11-06 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US10265064B2 (en) | 2004-11-05 | 2019-04-23 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US8317825B2 (en) | 2004-11-09 | 2012-11-27 | Biomet Sports Medicine, Llc | Soft tissue conduit device and method |
US7914539B2 (en) | 2004-11-09 | 2011-03-29 | Biomet Sports Medicine, Llc | Tissue fixation device |
US20060189993A1 (en) * | 2004-11-09 | 2006-08-24 | Arthrotek, Inc. | Soft tissue conduit device |
US8034090B2 (en) | 2004-11-09 | 2011-10-11 | Biomet Sports Medicine, Llc | Tissue fixation device |
US8998949B2 (en) | 2004-11-09 | 2015-04-07 | Biomet Sports Medicine, Llc | Soft tissue conduit device |
US20060135638A1 (en) * | 2004-12-22 | 2006-06-22 | Pedrozo Hugo A | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
US9402616B2 (en) | 2005-02-07 | 2016-08-02 | Ivy Sports Medicine, Llc | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US10548590B2 (en) | 2005-02-07 | 2020-02-04 | Ivy Sports Medicine, Llc | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US20060178680A1 (en) * | 2005-02-07 | 2006-08-10 | Regen Biologics, Inc. | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US9949732B2 (en) | 2005-02-07 | 2018-04-24 | Ivy Sports Medicine, Llc | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US8808309B2 (en) | 2005-02-07 | 2014-08-19 | Ivy Sports Medicine, Llc | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US8128640B2 (en) | 2005-02-07 | 2012-03-06 | Ivy Sports Medicine LLC | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US9956315B2 (en) * | 2005-04-29 | 2018-05-01 | Cook Biotech Incorporated | Fistula graft with deformable sheet-form material |
US20070088445A1 (en) * | 2005-04-29 | 2007-04-19 | Patel Umesh H | Fistula graft with deformable sheet-form material |
US11633292B2 (en) | 2005-05-24 | 2023-04-25 | Si-Bone Inc. | Apparatus, systems, and methods for the fixation or fusion of bone |
US20200345508A1 (en) * | 2005-05-24 | 2020-11-05 | Si-Bone Inc. | Apparatus, systems, and methods for the fixation or fusion of bone |
US20070009610A1 (en) * | 2005-07-11 | 2007-01-11 | Carina Syring | Engineered osteochondral construct for treatment of articular cartilage defects |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
US8202306B2 (en) * | 2005-09-12 | 2012-06-19 | Arthrex, Inc. | Mesh reinforced tissue anchor |
US20070060923A1 (en) * | 2005-09-12 | 2007-03-15 | Arthrex, Inc. | Mesh reinforced tissue anchor |
US20100131074A1 (en) * | 2005-09-13 | 2010-05-27 | Takiron Co., Ltd. | Composite porous object |
US9701940B2 (en) | 2005-09-19 | 2017-07-11 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
US20070114261A1 (en) * | 2005-11-23 | 2007-05-24 | Ethicon Endo-Surgery, Inc. | Surgical stapler with a bendable end effector |
US9011535B2 (en) * | 2005-12-20 | 2015-04-21 | Depuy Mitek, Llc | Methods for ligament reconstruction |
US9241785B2 (en) | 2005-12-20 | 2016-01-26 | Depuy Mitek, Llc | Methods for ligament reconstruction |
US9931194B2 (en) | 2005-12-20 | 2018-04-03 | Depuy Mitek, Llc | Ligament grafts for ligament reconstruction |
US20130172998A1 (en) * | 2005-12-20 | 2013-07-04 | Depuy Mitek, Llc | Methods for ligament reconstruction |
US7905904B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US11259792B2 (en) | 2006-02-03 | 2022-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US8597327B2 (en) | 2006-02-03 | 2013-12-03 | Biomet Manufacturing, Llc | Method and apparatus for sternal closure |
US8608777B2 (en) | 2006-02-03 | 2013-12-17 | Biomet Sports Medicine | Method and apparatus for coupling soft tissue to a bone |
US8632569B2 (en) | 2006-02-03 | 2014-01-21 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US8652172B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Flexible anchors for tissue fixation |
US8652171B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US10973507B2 (en) | 2006-02-03 | 2021-04-13 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10932770B2 (en) | 2006-02-03 | 2021-03-02 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US8721684B2 (en) | 2006-02-03 | 2014-05-13 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US11589859B2 (en) | 2006-02-03 | 2023-02-28 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US10729421B2 (en) | 2006-02-03 | 2020-08-04 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US10729430B2 (en) | 2006-02-03 | 2020-08-04 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10716557B2 (en) | 2006-02-03 | 2020-07-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US8771316B2 (en) | 2006-02-03 | 2014-07-08 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US11617572B2 (en) | 2006-02-03 | 2023-04-04 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US9532777B2 (en) | 2006-02-03 | 2017-01-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9510819B2 (en) | 2006-02-03 | 2016-12-06 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US11039826B2 (en) | 2006-02-03 | 2021-06-22 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8574235B2 (en) | 2006-02-03 | 2013-11-05 | Biomet Sports Medicine, Llc | Method for trochanteric reattachment |
US11065103B2 (en) | 2006-02-03 | 2021-07-20 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US10702259B2 (en) | 2006-02-03 | 2020-07-07 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US8088130B2 (en) | 2006-02-03 | 2012-01-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10695052B2 (en) | 2006-02-03 | 2020-06-30 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10687803B2 (en) | 2006-02-03 | 2020-06-23 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10675073B2 (en) | 2006-02-03 | 2020-06-09 | Biomet Sports Medicine, Llc | Method and apparatus for sternal closure |
US7909851B2 (en) | 2006-02-03 | 2011-03-22 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US10603029B2 (en) | 2006-02-03 | 2020-03-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US10595851B2 (en) | 2006-02-03 | 2020-03-24 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US11471147B2 (en) | 2006-02-03 | 2022-10-18 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10542967B2 (en) | 2006-02-03 | 2020-01-28 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10517587B2 (en) | 2006-02-03 | 2019-12-31 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8273106B2 (en) | 2006-02-03 | 2012-09-25 | Biomet Sports Medicine, Llc | Soft tissue repair and conduit device |
US8932331B2 (en) | 2006-02-03 | 2015-01-13 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US8936621B2 (en) | 2006-02-03 | 2015-01-20 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8968364B2 (en) | 2006-02-03 | 2015-03-03 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US7905903B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US10441264B2 (en) | 2006-02-03 | 2019-10-15 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US9005287B2 (en) | 2006-02-03 | 2015-04-14 | Biomet Sports Medicine, Llc | Method for bone reattachment |
US11116495B2 (en) | 2006-02-03 | 2021-09-14 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US10398428B2 (en) | 2006-02-03 | 2019-09-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US11723648B2 (en) | 2006-02-03 | 2023-08-15 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US10321906B2 (en) | 2006-02-03 | 2019-06-18 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US10987099B2 (en) | 2006-02-03 | 2021-04-27 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US10251637B2 (en) | 2006-02-03 | 2019-04-09 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US11284884B2 (en) | 2006-02-03 | 2022-03-29 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US11730464B2 (en) | 2006-02-03 | 2023-08-22 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US7857830B2 (en) | 2006-02-03 | 2010-12-28 | Biomet Sports Medicine, Llc | Soft tissue repair and conduit device |
US9149267B2 (en) | 2006-02-03 | 2015-10-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9173651B2 (en) | 2006-02-03 | 2015-11-03 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US10154837B2 (en) | 2006-02-03 | 2018-12-18 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10098629B2 (en) | 2006-02-03 | 2018-10-16 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10092288B2 (en) | 2006-02-03 | 2018-10-09 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US11896210B2 (en) | 2006-02-03 | 2024-02-13 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8292921B2 (en) | 2006-02-03 | 2012-10-23 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US11786236B2 (en) | 2006-02-03 | 2023-10-17 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US9271713B2 (en) | 2006-02-03 | 2016-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for tensioning a suture |
US11819205B2 (en) | 2006-02-03 | 2023-11-21 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US10022118B2 (en) | 2006-02-03 | 2018-07-17 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US10004489B2 (en) | 2006-02-03 | 2018-06-26 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US11311287B2 (en) | 2006-02-03 | 2022-04-26 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US10004588B2 (en) | 2006-02-03 | 2018-06-26 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US9993241B2 (en) | 2006-02-03 | 2018-06-12 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8298262B2 (en) | 2006-02-03 | 2012-10-30 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8337525B2 (en) | 2006-02-03 | 2012-12-25 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US9402621B2 (en) | 2006-02-03 | 2016-08-02 | Biomet Sports Medicine, LLC. | Method for tissue fixation |
US9414833B2 (en) | 2006-02-03 | 2016-08-16 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US11317907B2 (en) | 2006-02-03 | 2022-05-03 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US11446019B2 (en) | 2006-02-03 | 2022-09-20 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8361113B2 (en) | 2006-02-03 | 2013-01-29 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9510821B2 (en) | 2006-02-03 | 2016-12-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US9801620B2 (en) | 2006-02-03 | 2017-10-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US9468433B2 (en) | 2006-02-03 | 2016-10-18 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US9763656B2 (en) | 2006-02-03 | 2017-09-19 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US7749250B2 (en) | 2006-02-03 | 2010-07-06 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US8409253B2 (en) | 2006-02-03 | 2013-04-02 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US9538998B2 (en) | 2006-02-03 | 2017-01-10 | Biomet Sports Medicine, Llc | Method and apparatus for fracture fixation |
US9561025B2 (en) | 2006-02-03 | 2017-02-07 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US9492158B2 (en) | 2006-02-03 | 2016-11-15 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9642661B2 (en) | 2006-02-03 | 2017-05-09 | Biomet Sports Medicine, Llc | Method and Apparatus for Sternal Closure |
US9498204B2 (en) | 2006-02-03 | 2016-11-22 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US9622736B2 (en) | 2006-02-03 | 2017-04-18 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US9603591B2 (en) | 2006-02-03 | 2017-03-28 | Biomet Sports Medicine, Llc | Flexible anchors for tissue fixation |
US20090157194A1 (en) * | 2006-03-10 | 2009-06-18 | Takiron Co., Ltd. | Implant composite material |
US8777956B2 (en) | 2006-08-16 | 2014-07-15 | Biomet Sports Medicine, Llc | Chondral defect repair |
US8251998B2 (en) | 2006-08-16 | 2012-08-28 | Biomet Sports Medicine, Llc | Chondral defect repair |
US20080109018A1 (en) * | 2006-09-12 | 2008-05-08 | Small Bone Innovations International Sas | Surgical clip |
US9078644B2 (en) | 2006-09-29 | 2015-07-14 | Biomet Sports Medicine, Llc | Fracture fixation device |
US9486211B2 (en) | 2006-09-29 | 2016-11-08 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US11672527B2 (en) | 2006-09-29 | 2023-06-13 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US7658751B2 (en) | 2006-09-29 | 2010-02-09 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US9539003B2 (en) | 2006-09-29 | 2017-01-10 | Biomet Sports Medicine, LLC. | Method and apparatus for forming a self-locking adjustable loop |
US10517714B2 (en) | 2006-09-29 | 2019-12-31 | Biomet Sports Medicine, Llc | Ligament system for knee joint |
US9918826B2 (en) | 2006-09-29 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US10695045B2 (en) | 2006-09-29 | 2020-06-30 | Biomet Sports Medicine, Llc | Method and apparatus for attaching soft tissue to bone |
US10835232B2 (en) | 2006-09-29 | 2020-11-17 | Biomet Sports Medicine, Llc | Fracture fixation device |
US8672969B2 (en) | 2006-09-29 | 2014-03-18 | Biomet Sports Medicine, Llc | Fracture fixation device |
US8231654B2 (en) | 2006-09-29 | 2012-07-31 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US11376115B2 (en) | 2006-09-29 | 2022-07-05 | Biomet Sports Medicine, Llc | Prosthetic ligament system for knee joint |
US10398430B2 (en) | 2006-09-29 | 2019-09-03 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US11096684B2 (en) | 2006-09-29 | 2021-08-24 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8500818B2 (en) | 2006-09-29 | 2013-08-06 | Biomet Manufacturing, Llc | Knee prosthesis assembly with ligament link |
US9833230B2 (en) | 2006-09-29 | 2017-12-05 | Biomet Sports Medicine, Llc | Fracture fixation device |
US8672968B2 (en) | 2006-09-29 | 2014-03-18 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US11259794B2 (en) | 2006-09-29 | 2022-03-01 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US9681940B2 (en) | 2006-09-29 | 2017-06-20 | Biomet Sports Medicine, Llc | Ligament system for knee joint |
US8562647B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for securing soft tissue to bone |
US8801783B2 (en) | 2006-09-29 | 2014-08-12 | Biomet Sports Medicine, Llc | Prosthetic ligament system for knee joint |
US9724090B2 (en) | 2006-09-29 | 2017-08-08 | Biomet Manufacturing, Llc | Method and apparatus for attaching soft tissue to bone |
US10610217B2 (en) | 2006-09-29 | 2020-04-07 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US10349931B2 (en) | 2006-09-29 | 2019-07-16 | Biomet Sports Medicine, Llc | Fracture fixation device |
US20080082128A1 (en) * | 2006-09-29 | 2008-04-03 | Arthrotek, Inc. | Method and apparatus for forming a self-locking adjustable suture loop |
US10004493B2 (en) | 2006-09-29 | 2018-06-26 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US10743925B2 (en) | 2006-09-29 | 2020-08-18 | Biomet Sports Medicine, Llc | Fracture fixation device |
US9788876B2 (en) | 2006-09-29 | 2017-10-17 | Biomet Sports Medicine, Llc | Fracture fixation device |
US8562645B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US7959650B2 (en) | 2006-09-29 | 2011-06-14 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US9414925B2 (en) | 2006-09-29 | 2016-08-16 | Biomet Manufacturing, Llc | Method of implanting a knee prosthesis assembly with a ligament link |
US20080140094A1 (en) * | 2006-12-11 | 2008-06-12 | Schwartz Herbert E | Unitary surgical device and method |
US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
US11612391B2 (en) | 2007-01-16 | 2023-03-28 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US8906110B2 (en) | 2007-01-24 | 2014-12-09 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20080220044A1 (en) * | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US20100015202A1 (en) * | 2007-03-06 | 2010-01-21 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US20080228271A1 (en) * | 2007-03-13 | 2008-09-18 | Biomet Sports Medicine, Inc. | Method and apparatus for graft fixation |
US8147546B2 (en) | 2007-03-13 | 2012-04-03 | Biomet Sports Medicine, Llc | Method and apparatus for graft fixation |
US8900301B2 (en) | 2007-03-13 | 2014-12-02 | Biomet Sports Medicine, Llc | Method and apparatus for graft fixation |
US9017381B2 (en) | 2007-04-10 | 2015-04-28 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US9861351B2 (en) | 2007-04-10 | 2018-01-09 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US10729423B2 (en) | 2007-04-10 | 2020-08-04 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US11185320B2 (en) | 2007-04-10 | 2021-11-30 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US20110060183A1 (en) * | 2007-09-12 | 2011-03-10 | Salvatore Castro | Multi-instrument access devices and systems |
US20090227843A1 (en) * | 2007-09-12 | 2009-09-10 | Smith Jeffrey A | Multi-instrument access devices and systems |
US20090149893A1 (en) * | 2007-12-05 | 2009-06-11 | Semler Eric J | Cancellous Bone Implant for Cartilage Repair |
US11690722B2 (en) * | 2008-02-28 | 2023-07-04 | Biopoly, Llc | Partial joint resurfacing implant, instrumentation, and method |
US20110185560A1 (en) * | 2008-08-18 | 2011-08-04 | Qioptiq Photonics Gmbh & Co. Kg | Method for producing an objective |
US20100049244A1 (en) * | 2008-08-20 | 2010-02-25 | Tyco Healthcare Group Lp | Double threaded tissue tack |
US8551137B2 (en) | 2008-08-20 | 2013-10-08 | Covidien Lp | Double threaded tissue tack |
US8740935B2 (en) | 2008-08-20 | 2014-06-03 | Covidien Lp | Double threaded tissue tack |
US11534159B2 (en) | 2008-08-22 | 2022-12-27 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US20100063541A1 (en) * | 2008-09-05 | 2010-03-11 | Pegasus Biologies, Inc. | Oblong cross-sectional tissue fixation peg |
US9089415B2 (en) * | 2008-09-05 | 2015-07-28 | Synovis Orthopedic And Woundcare, Inc. | Oblong cross-sectional tissue fixation peg |
US10980925B1 (en) | 2008-10-14 | 2021-04-20 | A Hoyos Llc | High definition liposculpture |
US8900314B2 (en) | 2009-05-28 | 2014-12-02 | Biomet Manufacturing, Llc | Method of implanting a prosthetic knee joint assembly |
US8343227B2 (en) | 2009-05-28 | 2013-01-01 | Biomet Manufacturing Corp. | Knee prosthesis assembly with ligament link |
US10149767B2 (en) | 2009-05-28 | 2018-12-11 | Biomet Manufacturing, Llc | Method of implanting knee prosthesis assembly with ligament link |
US20110184231A1 (en) * | 2009-07-28 | 2011-07-28 | Page Brett M | Deflectable instrument ports |
US10231744B2 (en) | 2009-08-20 | 2019-03-19 | Howmedica Osteonics Corp. | Flexible ACL instrumentation, kit and method |
US11364041B2 (en) | 2009-08-20 | 2022-06-21 | Howmedica Osteonics Corp. | Flexible ACL instrumentation, kit and method |
US10736676B2 (en) | 2010-06-02 | 2020-08-11 | Wright Medical Technology, Inc. | Orthopedic implant kit |
US9724140B2 (en) | 2010-06-02 | 2017-08-08 | Wright Medical Technology, Inc. | Tapered, cylindrical cruciform hammer toe implant and method |
US9603643B2 (en) | 2010-06-02 | 2017-03-28 | Wright Medical Technology, Inc. | Hammer toe implant with expansion portion for retrograde approach |
US9498273B2 (en) | 2010-06-02 | 2016-11-22 | Wright Medical Technology, Inc. | Orthopedic implant kit |
US9877753B2 (en) | 2010-06-02 | 2018-01-30 | Wright Medical Technology, Inc. | Orthopedic implant kit |
US20130053975A1 (en) * | 2010-06-02 | 2013-02-28 | Wright Medical Technology, Inc. | Hammer toe implant method |
US9949775B2 (en) | 2010-06-02 | 2018-04-24 | Wright Medical Technology, Inc. | Hammer toe implant with expansion portion for retrograde approach |
US9044287B2 (en) * | 2010-06-02 | 2015-06-02 | Wright Medical Technology, Inc. | Hammer toe implant method |
EP2446837A2 (en) | 2010-10-28 | 2012-05-02 | Tyco Healthcare Group LP | Wound closure device including barbed pins |
US9220499B2 (en) * | 2010-10-28 | 2015-12-29 | Covidien Lp | Wound closure device including barbed pins |
US20120109188A1 (en) * | 2010-10-28 | 2012-05-03 | Tyco Healthcare Group Lp | Wound Closure Device Including Barbed Pins |
US8771352B2 (en) | 2011-05-17 | 2014-07-08 | Biomet Sports Medicine, Llc | Method and apparatus for tibial fixation of an ACL graft |
US9216078B2 (en) | 2011-05-17 | 2015-12-22 | Biomet Sports Medicine, Llc | Method and apparatus for tibial fixation of an ACL graft |
US9445827B2 (en) | 2011-10-25 | 2016-09-20 | Biomet Sports Medicine, Llc | Method and apparatus for intraosseous membrane reconstruction |
US8506597B2 (en) | 2011-10-25 | 2013-08-13 | Biomet Sports Medicine, Llc | Method and apparatus for interosseous membrane reconstruction |
US10265159B2 (en) | 2011-11-03 | 2019-04-23 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US9357991B2 (en) | 2011-11-03 | 2016-06-07 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US11241305B2 (en) | 2011-11-03 | 2022-02-08 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US10363028B2 (en) | 2011-11-10 | 2019-07-30 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US10368856B2 (en) | 2011-11-10 | 2019-08-06 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US9381013B2 (en) | 2011-11-10 | 2016-07-05 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9370350B2 (en) | 2011-11-10 | 2016-06-21 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US11534157B2 (en) | 2011-11-10 | 2022-12-27 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9357992B2 (en) | 2011-11-10 | 2016-06-07 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9314241B2 (en) | 2011-11-10 | 2016-04-19 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US10448944B2 (en) | 2011-11-23 | 2019-10-22 | Howmedica Osteonics Corp. | Filamentary fixation device |
US9445803B2 (en) | 2011-11-23 | 2016-09-20 | Howmedica Osteonics Corp. | Filamentary suture anchor |
US11844508B2 (en) | 2011-11-23 | 2023-12-19 | Howmedica Osteonics Corp. | Filamentary fixation device |
US9259217B2 (en) | 2012-01-03 | 2016-02-16 | Biomet Manufacturing, Llc | Suture Button |
US9433407B2 (en) | 2012-01-03 | 2016-09-06 | Biomet Manufacturing, Llc | Method of implanting a bone fixation assembly |
US11033311B2 (en) * | 2012-01-12 | 2021-06-15 | University Of Kansas | Compact orthopedic anti-rotation device |
US20130184768A1 (en) * | 2012-01-12 | 2013-07-18 | Terence Edward McIff | Compact orthopedic anti-rotation device |
US11129656B2 (en) | 2012-01-12 | 2021-09-28 | University Of Kansas | Compact orthopedic anti-rotation device |
WO2013123509A1 (en) * | 2012-02-17 | 2013-08-22 | Bacterin International, Inc. | Adjustable bioactive agent dispersion within a polymeric coating |
US11672664B2 (en) | 2012-03-09 | 2023-06-13 | Si-Bone Inc. | Systems, devices, and methods for joint fusion |
US11471286B2 (en) | 2012-03-09 | 2022-10-18 | Si-Bone Inc. | Systems, devices, and methods for joint fusion |
US10363140B2 (en) | 2012-03-09 | 2019-07-30 | Si-Bone Inc. | Systems, device, and methods for joint fusion |
US9044321B2 (en) | 2012-03-09 | 2015-06-02 | Si-Bone Inc. | Integrated implant |
US10201427B2 (en) | 2012-03-09 | 2019-02-12 | Si-Bone Inc. | Integrated implant |
US11337821B2 (en) | 2012-03-09 | 2022-05-24 | Si-Bone Inc. | Integrated implant |
US8778026B2 (en) | 2012-03-09 | 2014-07-15 | Si-Bone Inc. | Artificial SI joint |
US11076865B2 (en) | 2012-04-06 | 2021-08-03 | Howmedica Osteonics Corp. | Knotless filament anchor for soft tissue repair |
US9808242B2 (en) | 2012-04-06 | 2017-11-07 | Howmedica Osteonics Corp. | Knotless filament anchor for soft tissue repair |
US20230095586A1 (en) * | 2012-05-04 | 2023-03-30 | Si-Bone Inc. | Fenestrated implant |
US10426533B2 (en) | 2012-05-04 | 2019-10-01 | Si-Bone Inc. | Fenestrated implant |
US11291485B2 (en) | 2012-05-04 | 2022-04-05 | Si-Bone Inc. | Fenestrated implant |
US11446069B2 (en) | 2012-05-04 | 2022-09-20 | Si-Bone Inc. | Fenestrated implant |
US11478287B2 (en) | 2012-05-04 | 2022-10-25 | Si-Bone Inc. | Fenestrated implant |
US11253297B2 (en) * | 2012-05-22 | 2022-02-22 | Lifenet Health | Cortical bone pin |
US10653462B2 (en) * | 2012-05-22 | 2020-05-19 | Lifenet Health | Cortical bone pin |
US20150150607A1 (en) * | 2012-05-22 | 2015-06-04 | Lifenet Health | Cortical Bone Pin |
US10653410B2 (en) | 2012-08-03 | 2020-05-19 | Howmedica Osteonics Corp. | Soft tissue fixation devices and methods |
US8821494B2 (en) | 2012-08-03 | 2014-09-02 | Howmedica Osteonics Corp. | Surgical instruments and methods of use |
US9226744B2 (en) | 2012-08-03 | 2016-01-05 | Howmedica Osteonics Corp. | Surgical instruments and methods of use |
US10123792B2 (en) | 2012-08-03 | 2018-11-13 | Howmedica Osteonics Corp. | Soft tissue fixation devices and methods |
US10278828B2 (en) | 2012-12-31 | 2019-05-07 | Wright Medical Technology, Inc. | Ball and socket implants for correction of hammer toes and claw toes |
US9504582B2 (en) | 2012-12-31 | 2016-11-29 | Wright Medical Technology, Inc. | Ball and socket implants for correction of hammer toes and claw toes |
US9402620B2 (en) | 2013-03-04 | 2016-08-02 | Howmedica Osteonics Corp. | Knotless filamentary fixation devices, assemblies and systems and methods of assembly and use |
US10285685B2 (en) | 2013-03-04 | 2019-05-14 | Howmedica Osteonics Corp. | Knotless filamentary fixation devices, assemblies and systems and methods of assembly and use |
US9757119B2 (en) | 2013-03-08 | 2017-09-12 | Biomet Sports Medicine, Llc | Visual aid for identifying suture limbs arthroscopically |
US9788826B2 (en) | 2013-03-11 | 2017-10-17 | Howmedica Osteonics Corp. | Filamentary fixation device and assembly and method of assembly, manufacture and use |
US9463013B2 (en) | 2013-03-13 | 2016-10-11 | Stryker Corporation | Adjustable continuous filament structure and method of manufacture and use |
US11446062B2 (en) * | 2013-03-14 | 2022-09-20 | Kinamed, Inc. | Vector compression system |
US9918827B2 (en) | 2013-03-14 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US10758221B2 (en) | 2013-03-14 | 2020-09-01 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US10959758B2 (en) | 2013-03-15 | 2021-03-30 | Si-Bone Inc. | Implants for spinal fixation or fusion |
US9936983B2 (en) | 2013-03-15 | 2018-04-10 | Si-Bone Inc. | Implants for spinal fixation or fusion |
US11331094B2 (en) | 2013-04-22 | 2022-05-17 | Stryker Corporation | Method and apparatus for attaching tissue to bone |
US9573260B2 (en) * | 2013-05-08 | 2017-02-21 | Arthur R. Walters, JR. | Fastening device for driving double-headed fasteners |
US20140331474A1 (en) * | 2013-05-08 | 2014-11-13 | Arthur R. Walters, JR. | Fastening device for driving double-headed fasteners |
US20140371748A1 (en) * | 2013-06-17 | 2014-12-18 | Gc Corporation | Fracture treatment device |
US9724139B2 (en) | 2013-10-01 | 2017-08-08 | Wright Medical Technology, Inc. | Hammer toe implant and method |
US9839448B2 (en) | 2013-10-15 | 2017-12-12 | Si-Bone Inc. | Implant placement |
US11147688B2 (en) | 2013-10-15 | 2021-10-19 | Si-Bone Inc. | Implant placement |
US9474561B2 (en) | 2013-11-19 | 2016-10-25 | Wright Medical Technology, Inc. | Two-wire technique for installing hammertoe implant |
US9675392B2 (en) | 2013-11-19 | 2017-06-13 | Wright Medical Technology, Inc. | Two-wire technique for installing hammertoe implant |
US10610211B2 (en) | 2013-12-12 | 2020-04-07 | Howmedica Osteonics Corp. | Filament engagement system and methods of use |
US10806443B2 (en) | 2013-12-20 | 2020-10-20 | Biomet Sports Medicine, Llc | Knotless soft tissue devices and techniques |
US10136886B2 (en) | 2013-12-20 | 2018-11-27 | Biomet Sports Medicine, Llc | Knotless soft tissue devices and techniques |
US11648004B2 (en) | 2013-12-20 | 2023-05-16 | Biomet Sports Medicine, Llc | Knotless soft tissue devices and techniques |
US9498266B2 (en) | 2014-02-12 | 2016-11-22 | Wright Medical Technology, Inc. | Intramedullary implant, system, and method for inserting an implant into a bone |
US9545274B2 (en) | 2014-02-12 | 2017-01-17 | Wright Medical Technology, Inc. | Intramedullary implant, system, and method for inserting an implant into a bone |
US20140166726A1 (en) * | 2014-02-24 | 2014-06-19 | Ethicon Endo-Surgery, Inc. | Staple cartridge including a barbed staple |
US9615822B2 (en) | 2014-05-30 | 2017-04-11 | Biomet Sports Medicine, Llc | Insertion tools and method for soft anchor |
US9700291B2 (en) | 2014-06-03 | 2017-07-11 | Biomet Sports Medicine, Llc | Capsule retractor |
US10039543B2 (en) | 2014-08-22 | 2018-08-07 | Biomet Sports Medicine, Llc | Non-sliding soft anchor |
US11219443B2 (en) | 2014-08-22 | 2022-01-11 | Biomet Sports Medicine, Llc | Non-sliding soft anchor |
US10743856B2 (en) | 2014-08-22 | 2020-08-18 | Biomet Sports Medicine, Llc | Non-sliding soft anchor |
US9662157B2 (en) | 2014-09-18 | 2017-05-30 | Si-Bone Inc. | Matrix implant |
US9808296B2 (en) | 2014-09-18 | 2017-11-07 | Wright Medical Technology, Inc. | Hammertoe implant and instrument |
US11071573B2 (en) | 2014-09-18 | 2021-07-27 | Si-Bone Inc. | Matrix implant |
US10166033B2 (en) | 2014-09-18 | 2019-01-01 | Si-Bone Inc. | Implants for bone fixation or fusion |
US10194962B2 (en) | 2014-09-18 | 2019-02-05 | Si-Bone Inc. | Matrix implant |
US10299840B2 (en) | 2014-09-18 | 2019-05-28 | Wright Medical Technology, Inc. | Hammertoe implant and instrument |
US11684378B2 (en) | 2014-09-18 | 2023-06-27 | Si-Bone Inc. | Implants for bone fixation or fusion |
US11607314B2 (en) * | 2014-10-22 | 2023-03-21 | Biomet C.V. | Method and apparatus for bone fixation |
US9986992B2 (en) | 2014-10-28 | 2018-06-05 | Stryker Corporation | Suture anchor and associated methods of use |
US11006945B2 (en) | 2014-10-28 | 2021-05-18 | Stryker Corporation | Suture anchor and associated methods of use |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US10568616B2 (en) | 2014-12-17 | 2020-02-25 | Howmedica Osteonics Corp. | Instruments and methods of soft tissue fixation |
US10080597B2 (en) | 2014-12-19 | 2018-09-25 | Wright Medical Technology, Inc. | Intramedullary anchor for interphalangeal arthrodesis |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
US9955980B2 (en) | 2015-02-24 | 2018-05-01 | Biomet Sports Medicine, Llc | Anatomic soft tissue repair |
US10912551B2 (en) | 2015-03-31 | 2021-02-09 | Biomet Sports Medicine, Llc | Suture anchor with soft anchor of electrospun fibers |
US10376206B2 (en) | 2015-04-01 | 2019-08-13 | Si-Bone Inc. | Neuromonitoring systems and methods for bone fixation or fusion procedures |
US10178991B2 (en) | 2015-04-22 | 2019-01-15 | Sofradim Production | Method for forming a barbed suture and the barbed suture thus obtained |
US11098422B2 (en) | 2015-04-22 | 2021-08-24 | Sofradim Production | Method for forming a barbed suture and the barbed suture thus obtained |
US10433944B2 (en) | 2015-04-23 | 2019-10-08 | Sofradim Production | Package for a surgical mesh |
US10959824B2 (en) | 2015-04-23 | 2021-03-30 | Sofradim Production | Package for a surgical mesh |
US10376367B2 (en) | 2015-07-02 | 2019-08-13 | First Ray, LLC | Orthopedic fasteners, instruments and methods |
US10765423B2 (en) | 2015-10-30 | 2020-09-08 | New York Society For The Relief Of The Ruptured And Crippled, Maintaing The Hospital For Special Surgery | Suture sleeve patch and methods of delivery within an existing arthroscopic workflow |
US11375996B2 (en) | 2015-10-30 | 2022-07-05 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Suture sleeve patch and methods of delivery within an existing arthroscopic workflow |
US11426156B2 (en) | 2015-10-30 | 2022-08-30 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Suture sleeve patch and methods of delivery within an existing arthroscopic workflow |
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US10835235B2 (en) | 2015-10-30 | 2020-11-17 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Suture sleeve patch and methods of delivery within an existing arthroscopic workflow |
US10357260B2 (en) | 2015-11-02 | 2019-07-23 | First Ray, LLC | Orthopedic fastener, retainer, and guide methods |
US10702290B2 (en) | 2015-11-02 | 2020-07-07 | First Ray, LLC | Orthopedic fastener, retainer, and guide |
US11484401B2 (en) | 2016-02-01 | 2022-11-01 | Medos International Sarl | Tissue augmentation scaffolds for use in soft tissue fixation repair |
US10702260B2 (en) | 2016-02-01 | 2020-07-07 | Medos International Sàrl | Soft tissue fixation repair methods using tissue augmentation scaffolds |
US11357495B2 (en) | 2016-02-01 | 2022-06-14 | Medos International Sarl | Tissue augmentation scaffolds for use with soft tissue fixation repair systems and methods |
US11523812B2 (en) | 2016-02-01 | 2022-12-13 | Medos International Sarl | Soft tissue fixation repair methods using tissue augmentation constructs |
US11696752B2 (en) | 2016-05-26 | 2023-07-11 | Stryker Corporation | Systems and methods for all-inside suture fixation for implant attachment and soft tissue repair |
US10932769B2 (en) | 2016-05-26 | 2021-03-02 | Ivy Sports Medicine, Llc | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US11684467B2 (en) * | 2016-11-07 | 2023-06-27 | Acuitive Technologies, Inc. | In-situ curing biodegradable anchor with reinforcement |
US11116519B2 (en) | 2017-09-26 | 2021-09-14 | Si-Bone Inc. | Systems and methods for decorticating the sacroiliac joint |
US11877756B2 (en) | 2017-09-26 | 2024-01-23 | Si-Bone Inc. | Systems and methods for decorticating the sacroiliac joint |
USD902405S1 (en) | 2018-02-22 | 2020-11-17 | Stryker Corporation | Self-punching bone anchor inserter |
USD976405S1 (en) | 2018-02-22 | 2023-01-24 | Stryker Corporation | Self-punching bone anchor inserter |
USD958989S1 (en) | 2018-02-22 | 2022-07-26 | Stryker Corporation | Self-punching bone anchor inserter |
US11678997B2 (en) | 2019-02-14 | 2023-06-20 | Si-Bone Inc. | Implants for spinal fixation and or fusion |
US11234830B2 (en) | 2019-02-14 | 2022-02-01 | Si-Bone Inc. | Implants for spinal fixation and or fusion |
US11369419B2 (en) | 2019-02-14 | 2022-06-28 | Si-Bone Inc. | Implants for spinal fixation and or fusion |
USD989964S1 (en) | 2019-08-12 | 2023-06-20 | Lifenet Health | Medical implant device |
USD968608S1 (en) | 2019-08-12 | 2022-11-01 | Lifenet Health | Medical implant device |
USD968609S1 (en) | 2019-09-12 | 2022-11-01 | Lifenet Health | Medical implant device |
US11672570B2 (en) | 2019-11-27 | 2023-06-13 | Si-Bone Inc. | Bone stabilizing implants and methods of placement across SI Joints |
US11571245B2 (en) | 2019-11-27 | 2023-02-07 | Si-Bone Inc. | Bone stabilizing implants and methods of placement across SI joints |
US11752011B2 (en) | 2020-12-09 | 2023-09-12 | Si-Bone Inc. | Sacro-iliac joint stabilizing implants and methods of implantation |
US20230082982A1 (en) * | 2021-09-10 | 2023-03-16 | Olympus Corporation | Suture method |
Also Published As
Publication number | Publication date |
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EP1416866A4 (en) | 2007-04-18 |
AU2002322567B2 (en) | 2007-09-06 |
US8337537B2 (en) | 2012-12-25 |
WO2003007839A2 (en) | 2003-01-30 |
EP1416866A2 (en) | 2004-05-12 |
JP4197158B2 (en) | 2008-12-17 |
JP2004535250A (en) | 2004-11-25 |
WO2003007839A3 (en) | 2003-04-24 |
US20040220574A1 (en) | 2004-11-04 |
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