US20030181922A1 - Removable anchored lung volume reduction devices and methods - Google Patents
Removable anchored lung volume reduction devices and methods Download PDFInfo
- Publication number
- US20030181922A1 US20030181922A1 US10/103,487 US10348702A US2003181922A1 US 20030181922 A1 US20030181922 A1 US 20030181922A1 US 10348702 A US10348702 A US 10348702A US 2003181922 A1 US2003181922 A1 US 2003181922A1
- Authority
- US
- United States
- Prior art keywords
- air passageway
- anchor
- intra
- obstructing member
- obstructing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12104—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in an air passage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12159—Solid plugs; being solid before insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
- A61B2017/22067—Blocking; Occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2002/043—Bronchi
Definitions
- the present invention is generally directed to a removable anchored device, system, and method for treating Chronic Obstructive Pulmonary Disease (COPD).
- COPD Chronic Obstructive Pulmonary Disease
- the present invention is more particularly directed to providing an anchored intra-bronchial obstruction that may be removable.
- COPD has become a major cause of morbidity and mortality in the United States over the last three decades.
- COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema.
- the airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.
- COPD chronic obstructive pulmonary disease
- Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled beta-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, ipratropium bromide may be indicated. Further, courses of steroids, such as corticosteroids, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pneumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.
- lung transplantation is also an option.
- COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.
- a promising new therapy includes non-surgical apparatus and procedures for lung volume reduction by permanently obstructing the air passageway that communicates with the portion of the lung to be collapsed.
- the therapy includes placing an obstruction in the air passageway that prevents inhaled air from flowing into the portion of the lung to be collapsed. Lung volume reduction with concomitant improved pulmonary function may be obtained without the need for surgery.
- the effectiveness of obstructions may be enhanced if it is anchored in place.
- the effectiveness may also be enhanced if the obstruction is removable.
- the present invention provides an anchored intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway.
- the device includes an obstructing member that prevents air from being inhaled into the lung portion to collapse the lung portion, and an anchor that anchors the obstruction device within the air passageway when the anchor is deployed.
- the anchor may engage the air passageway wall, and may pierce into the air passageway wall.
- the obstructing member and the anchor may be simultaneously deployable.
- the anchor may be releasable from the air passageway for removal of the obstructing member.
- a portion of the intra-bronchial device may be collapsible.
- the anchor may be releasable from the air passageway for removal of the obstructing member by collapsing a portion of the obstructing member, or by drawing the obstructing member proximally.
- the anchor may include a resilient material for imparting a force against the air passageway to deform the air passageway to more positively anchor the obstructing member.
- the anchor may comprise material having memory of an original shape, and resiliency to return the material to that shape.
- the obstructing member may comprise material having memory of an original shape, and resiliency to return the material to that shape.
- the obstructing member may be a one-way valve.
- a method of reducing the size of a lung by collapsing a portion of the lung includes the step of providing an intra-bronchial device comprising an obstructing member which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and an anchor that anchors the obstructing member when the anchor is deployed.
- the method further includes the steps of placing the obstructing member in the air passageway, and deploying the anchor.
- the anchor may be releasable for removal of the obstructing member.
- the obstructing member may form a one-way valve. A portion of the obstructing member may be collapsible.
- a method of reducing the size of a lung by collapsing a portion of the lung with a removable device includes the step of providing an intra-bronchial device and an obstructing member that is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and an anchor that anchors the obstructing member when the anchor is deployed.
- the method includes the additional steps of placing the obstructing member in the air passageway, deploying an anchor, and removing the obstructing member.
- the anchor is releasable from the air passageway for removal of the intra-bronchial device, and the step of removing the obstructing member includes the further step of releasing the anchor.
- the obstructing member may form a one-way valve. At least a portion of the obstructing member may be collapsible, and the step of removing the obstructing member includes the further step of collapsing a portion of the obstructing member.
- an air passageway-obstructing device in yet another embodiment, includes obstructing means for obstructing air flow within the air passageway, and anchoring means to anchor the air passageway obstructing device within the air passageway.
- an air passageway-obstructing device that includes obstructing means for obstructing air flow within the air passageway, and anchoring means to anchor the air passageway obstructing device within the air passageway, the anchoring means being releasable for removal of the obstructing means from the air passageway.
- FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system
- FIG. 2 is a sectional view similar to FIG. 1, but illustrating a respiratory system suffering from COPD and the execution of a first step in treating the COPD condition by reducing the size of a lung portion in accordance with the present invention
- FIG. 3 is perspective view, partially in section, and to an enlarged scale, illustrating an intermediate step in the treatment
- FIG. 4 is a perspective view of a conduit that may be utilized in practicing the present invention.
- FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention
- FIG. 6 is a partial section view of the device of FIG. 5 showing additional details of the support structure
- FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway;
- FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention
- FIG. 9 is a perspective view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
- FIG. 10 is a side view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
- FIG. 11 is an end view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
- FIG. 12 is a perspective view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
- FIG. 13 is a side view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
- FIG. 14 is an end view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention
- FIG. 15 is a perspective view an intra-bronchial device similar to that of FIGS. 12 - 14 anchored in an air passageway;
- FIG. 16 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention
- FIG. 17 is a side view of the device of FIG. 16;
- FIG. 18 is a perspective view of a device in its deployed state with anchors carried on an obstructing member, in accordance with an alternative embodiment of the invention.
- FIG. 19 is a partial longitudinal sectional view of the device of FIG. 18 in a collapsed state and located into a lumen for placement in an air passageway;
- FIG. 20 is a perspective view of the device of FIG. 18 in its deployed and anchored state in an air passageway, in accordance with the present invention
- FIG. 21 is a side view of an initial step in removing the device of FIG. 18 from an air passageway;
- FIG. 22 is a side view of an intermediate step in removing the device of FIG. 18 from an air passageway;
- FIG. 23 is a side view of another intermediate step in removing the device of FIG. 18 from an air passageway;
- FIG. 24 is a side view illustrating the collapse of the device of FIG. 18 during its removal from an air passageway
- FIG. 25 is a perspective view of a device in its deployed state with anchors carried on the obstructing member, in accordance with an alternative embodiment of the present invention.
- FIG. 26 illustrates the placement and securing of the obstructing member of the device of FIG. 25 to a support member
- FIG. 27 is a perspective view of the intra-bronchial device of FIG. 25 fully deployed and anchored in an air passageway, in accordance with the present invention.
- proximal means nearest the trachea
- distal means nearest the bronchioles
- an aspect of the invention provides an anchored intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway.
- a further aspect of the invention provides removability of the intra-bronchial device, either by releasing the anchors for removal of the entire device or by separating the obstructing member and removing it.
- FIG. 1 is a sectional view of a healthy respiratory system.
- the respiratory system 20 resides within the thorax 22 that occupies a space defined by the chest wall 24 and the diaphragm 26 .
- the respiratory system 20 includes the trachea 28 , the left mainstem bronchus 30 , the right mainstem bronchus 32 , the bronchial branches 34 , 36 , 38 , 40 , and 42 and sub-branches 44 , 46 , 48 , and 50 .
- the respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56 , 58 , and 60 .
- Each bronchial branch and sub-branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof.
- air passageway is meant to denote either a bronchi or bronchiole, and typically means a bronchial branch or sub-branch which communicates with a corresponding individual lung lobe or lung lobe portion to provide inhaled air thereto or conduct exhaled air therefrom.
- Characteristic of a healthy respiratory system is the arched or inwardly arcuate diaphragm 26 .
- the diaphragm 26 straightens to increase the volume of the thorax 22 . This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air.
- the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes.
- FIG. 2 illustrates a respiratory system suffering from COPD.
- the lung lobes 52 , 54 , 56 , 58 , and 60 are enlarged and that the diaphragm 26 is not arched but substantially straight.
- this individual is incapable of breathing normally by moving diaphragm 28 .
- this individual in order to create the negative pressure in thorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths.
- bronchial sub-branch obstructing devices are generally employed for treating the apex 66 of the right, upper lung lobe 56 .
- the present invention may be applied to any lung portion without departing from the present invention.
- the present invention may be used with any type of obstructing member to provide an anchored obstructing device, which may be removed.
- the insertion of an obstructing member treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing the surgery.
- the treatment contemplates permanent collapse of a lung portion. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.
- the present invention supports the use of intra-bronchial plugs to treat COPD by anchoring the obstruction device in the air passageway.
- the present invention further supports the use of intra-bronchial plugs by providing for their removal if necessary.
- Use of anchors can allow the obstructing member to be relatively loosely fitted against the air passageway wall, which may provide increased mucociliary transport of mucus and debris out of the collapsed lung portion.
- FIG. 2 also illustrates a step in COPD treatment using an obstructing member.
- Treatment is initiated by feeding a conduit or catheter 70 down the trachea 28 , into the right mainstem bronchus 32 , into the bronchial branch 42 and into and terminating within the sub-branch 50 .
- the sub-branch 50 is the air passageway that communicates with the lung portion 66 to be treated, and is also referred to herein as air passageway 50 .
- the catheter 70 is preferably formed of flexible material such as polyethylene. Also, the catheter 70 is preferably preformed with a bend 72 to assist the feeding of the catheter from the right mainstem bronchus 32 into the bronchial branch 42 .
- FIG. 3 illustrates a further step in a method for placing an obstructing member 90 in a bronchial sub-branch using a catheter.
- Catheter 70 includes an optional inflatable sealing member 74 for use with a vacuum to collapse lung portion 66 prior to insertion of obstructing member 90 .
- the obstructing member 90 may be formed of resilient or collapsible material to enable the obstructing member 90 to be fed through the catheter 70 in a collapsed state.
- the obstructing member 90 and its anchors are collapsed and fed into the catheter 70 .
- the stylet 92 is used to push the obstructing member 90 to the end 77 of the catheter 70 for placing the obstructing member 90 within the air passageway 50 adjacent to the lung portion 66 to be permanently collapsed.
- Optional sealing member 74 is withdrawn after obstructing member 90 is inserted.
- a function of the intra-bronchial device disclosed and claimed in this specification, including the detailed description and the claims, is described in terms of collapsing a lung portion associated with an air passageway.
- a portion of a lung may receive air from collateral air passageways. Obstructing one of the collateral air passageways may reduce the volume of the lung portion associated with the air passageway, but not completely collapse the lung portion as that term may be generally understood.
- the meaning of “collapse” includes both a complete collapse of a lung portion and a partial collapse of a lung portion.
- the obstructing member precludes inhaled air from entering the lung portion to be collapsed.
- the obstructing member takes the form of a one-way valve.
- the member further allows air within the lung portion to be exhaled. This results in more rapid collapse of the lung portion.
- anchoring obstructing members that preclude both inhaled and exhaled airflow are contemplated as within the scope of the invention.
- FIG. 4 illustrates the obstructing device in place within air passageway 50 .
- Obstructing member 90 has expanded upon placement in the air passageway 50 to seal the air passageway 50 . This causes the lung portion 66 to be maintained in a permanently collapsed state.
- the obstructing member 90 may be any shape suitable for accomplishing its purpose, and may be a solid material or a membrane.
- the obstructing member 90 has an outer dimension 91 , and when expanded, enables a contact zone with the air passageway inner dimension 51 . This seals the air passageway upon placement of the obstructing member 90 in the air passageway 50 for maintaining the lung portion 66 in the collapsed state.
- the lung portion 66 may be collapsed using vacuum prior to placement of obstructing member 90 , or sealing the air passageway 50 with obstructing member 90 may collapse it. Over time, the air within the lung portion 66 will be absorbed by the body and result in the collapse of lung portion 66 .
- obstructing member 90 may include the function of a one-way valve that allows air to escape from lung portion 66 . Lung portion 66 will then collapse, and the valve will prevent air from being inhaled.
- FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention.
- Intra-bronchial device 100 includes a support structure 101 , a central support structure 109 ; support members 102 , 104 , 106 , and 108 ; anchors 112 , 114 , 116 , and 118 ; anchor ends 122 , 124 , 126 , and 128 ; and an obstructing member 110 .
- the support structure 101 of intra-bronchial device includes central support structure 109 , and support members 102 , 104 , 106 , and 108 .
- the support members 102 , 104 , 106 , and 108 carry anchors 112 , 114 , 116 , and 118 ; and anchor ends 122 , 124 , 126 , and 128 , respectively.
- Central support structure 109 is a tubular member, preferably hypodermic needle tubing.
- Support members 102 , 104 , 106 , and 108 are coupled mechanically to central support structure 109 , such as by crimping, or by other methods such as adhesive or welding.
- Support members 102 , 104 , 106 , and 108 are generally similar to each other.
- the support members are preferably formed of stainless steel, Nitinol, or other suitable material having a memory of its original shape, and resiliency to return the material to that shape.
- Anchors 112 , 114 , 116 , and 118 are extensions of support members 102 , 104 , 106 , and 108 .
- the anchors are formed by bending the support members to an angle that will result in a deployed anchor engaging the air passageway wall by piercing it approximately perpendicularly. In this preferred embodiment, the bend angle is approximately a right angle.
- Anchor ends 122 , 124 , 126 , and 128 may be shaped to promote piercing the air passageway wall.
- Obstructing member 110 is carried on the support structure 101 , and includes a flexible membrane open in the proximal direction and which may be formed of silicone or polyurethane, for example.
- the obstructing member 110 is secured to the central support structure 109 , and may be additionally secured to the support members at its larger diameter 91 . It may be secured by adhesive, or other manner known in the art.
- Obstructing member 110 may be loosely carried on support members 102 , 104 , 106 , and 108 , such that it expands on inhalation to form a seal against a wall of the air passageway, and contracts on exhalation to allow air and mucociliary transport from the collapsed lung. This provides a one-way valve function.
- FIG. 6 is a partial section view of the device of FIG. 5 showing additional detail of the support structure.
- the linear cross-section view of FIG. 6 exposes the arrangement of support members 106 and 108 in their deployed configuration.
- the details of support members 102 and 104 are omitted from FIG. 6 for clarity, but are the same as support members 106 and 108 .
- the distal end of obstructing member 110 is carried on central support structure 109 .
- Support members 106 and 108 are shown emanating from central support structure 109 , and arranged to loosely support to obstructing member 110 at its larger diameter 91 .
- obstructing member 110 to expand on inhalation and seal at the contact zone 129 , and to partially contract on exhalation to allow exhalation of air and mucociliary transport.
- support members 106 and 108 do not actively support obstructing member 110 , and the expansion and contraction of obstructing member 110 is governed by its elasticity.
- FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway.
- Intra-bronchial device 100 is illustrated with anchors 112 and 116 piercing into the air passageway wall 130 of air passageway 50 . This anchors the intra-bronchial device 100 in place.
- Intra-bronchial device 100 is collapsible for insertion into an internal lumen of a catheter. At least the support members 102 , 104 , 106 , and 108 , and the obstructing member 110 , may be collapsed. Intra-bronchial device 100 is inserted into the catheter lumen, which is typically already placed in the air passageway 50 as generally illustrated in FIG. 3. Using the stylet, intra-bronchial device 100 is advanced down the catheter lumen into the air passageway 50 to where the device is to be deployed. Once the point of deployment is reached, intra-bronchial device 100 is expelled from the catheter and assumes its deployed shape as illustrated in FIG. 5.
- obstructing member 110 expands to form a contact zone 129 with the wall 130 of the air passageway 50 to prevent air from being inhaled into the lung portion to collapse the lung portion.
- the memory and resiliency of the support members 102 , 104 , 106 , and 108 impart a force on the anchor ends 122 , 124 , 126 , and 128 , and urge the anchors 112 , 114 , 116 , and 118 to engage air passageway wall 130 by piercing.
- the anchors pierce into and become embedded in the wall 130 of the air passageway 50 , preferably without projecting through the wall 130 . Stops may be incorporated into the anchors to limit piercing of the wall 130 .
- the bend between the support member and the anchor may form a stop.
- the preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect of intra-bronchial device 100 .
- the preclusion of air by the embodiment illustrated in FIGS. 5 - 7 may be eliminated by releasing anchors 112 , 114 , 116 , and 118 from the air passageway wall 130 .
- the anchors may be released by inserting a catheter into air passageway 50 in proximity to intra-bronchial device 100 .
- a retractor device, such as biopsy forceps, capable of gripping a portion of intra-bronchial device 100 is inserted in the catheter. The forceps are used to engage a portion of the support structure 101 of intra-bronchial device 100 , and draw it toward the catheter.
- the drawing action releases anchors 112 , 114 , 116 , and 118 from air passageway wall 130 .
- the intra-bronchial device 110 is then drawn into the catheter with the forceps, causing the support structure 101 and obstructing member 110 to collapse.
- the collapsed device 100 now fully enters the catheter lumen for removal from the patient.
- the obstructing effect may be eliminated by grabbing the obstructing member 110 , releasing it from the support structure 101 , and removing obstructing member 110 from the patient.
- FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention.
- the anchors 112 , 114 , 116 , and 118 of intra-bronchial device 140 are carried on portions of support members 102 , 104 , 106 , and 108 distal of the central support structure 109 .
- the support members are gathered together and carried by the central support structure 109 .
- intra-bronchial device 140 is substantially similar in construction, operation, and removal as the intra-bronchial device 100 of FIG. 5.
- the anchors 112 , 114 , 116 , and 118 are collapsed into a first configuration.
- the anchor ends 122 , 124 , 126 , and 128 are moved toward obstructing member 110 , and anchors 112 , 114 , 116 , and 118 thereby folded toward obstructing member 110 .
- intra-bronchial device 100 When intra-bronchial device 100 is deployed from the catheter lumen, the memory and resiliency of the support members 102 , 104 , 106 , and 108 impart a force that moves the anchors 112 , 114 , 116 , and 118 into a second configuration to engage air passageway wall 130 . This is the deployed configuration illustrated in FIG. 8.
- drawing intra-bronchial device 140 toward the catheter causes the anchor ends 122 , 124 , 126 , and 128 to move away from obstructing member 110 to a third configuration.
- Anchors 112 , 114 , 116 , and 118 are thereby folded away from obstructing member 110 and are released from engagement with air passageway wall 130 for removal of the intra-bronchial device 140 .
- the anchors 112 , 114 , 116 , and 118 may be formed on additional support members carried by central support structure 109 , instead of being formed from distal portions of support members 102 , 104 , 106 , and 108 .
- FIGS. 9 - 11 illustrate an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
- FIG. 9 is a perspective view
- FIG. 10 is a side view
- FIG. 11 is an end view of the device.
- Intra-bronchial device 150 is generally similar in construction, operation, placement, and removal to the intra-bronchial device 100 of FIG. 5. Its structure has six support members and three anchors, with anchor stops. Anchors 112 , 114 , and 116 include stops 152 , 154 , and 156 , respectively.
- Intra-bronchial device 150 also includes an anchor base 160 , an anchor base aperture 165 , anchor base angle 163 , and additional support members 103 and 105 .
- Central support structure 109 extends both proximal and distal of obstructing member 110 , and carries anchor base 161 proximal of obstructing member 110 , carries anchors 112 , 114 , and 116 , and includes anchor base aperture 165 .
- the linear plane of anchors 112 , 114 , and 116 intersect anchor base 161 at anchor base angle 163 .
- Anchor base angle 163 is selected to optimize anchor deployment force and anchor release.
- Stops 152 , 154 , and 156 include a flat area to limit the piercing of the air passageway wall by anchor ends 122 , 124 , and 126 . In alternative embodiments, the stops can be any configuration or shape known to those skilled in the art to limit the piercing.
- anchors 112 , 114 , and 116 are collapsed into a first configuration.
- the anchor ends 122 , 124 , and 126 are moved toward obstructing member 110 , thereby decreasing anchor base angle 163 and folding anchors 112 , 114 , and 116 toward obstructing member 110 .
- the anchor ends and the anchors may be moved by sliding a catheter or hollow member over anchor base 161 and toward obstructing member 110 .
- the memory and resiliency of the anchors 112 , 114 , and 116 , anchor angle 163 , and anchor base 161 impart a force that moves the anchor members into a second configuration, which is the deployed configuration, to engage air passageway wall 130 .
- the second or deployed configuration is illustrated in FIGS. 9 - 11 . Stops 152 , 154 , and 156 limit the piercing of the air passageway wall by anchor ends 122 , 124 , and 126 .
- a retractor device is deployed from a catheter to engage anchor base 161 and restrain intra-bronchial device 150 .
- the retractor device may be a biopsy forceps to engage anchor base 161 , or a hooked device to engage anchor base aperture 165 .
- a catheter is then moved distally over anchor base 161 , and in contact with anchors 112 , 114 , and 116 .
- the catheter is further moved against anchors 112 , 114 , and 116 , while intra-bronchial device 150 is restrained at anchor base 161 . This releases the anchors 112 , 114 , and 116 from the air passageway wall. This collapses the anchors into to the first configuration for removal.
- Intra-bronchial device 150 is then further drawn into the catheter by pulling on the retractor device used to engage anchor base 161 . This collapses support structure 101 and obstructing member 110 so that they may be fully drawn into the catheter. Once drawn into the catheter, intra-bronchial device 160 may be removed from the air passageway and the patient.
- FIGS. 12 - 14 illustrate an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
- FIG. 12 is a perspective view
- FIG. 13 is a side view
- FIG. 14 is an end view.
- Intra-bronchial device 160 is generally similar in construction, placement, and operation to the intra-bronchial device 150 of FIGS. 9 - 11 .
- Intra-bronchial device 160 is removed in the manner described in conjunction with FIG. 7.
- Intra-bronchial device 160 differs from intra-bronchial device 150 in that the structure includes four distal anchors with anchor ends 122 , 124 , 126 , and 128 shaped into pads that deform and frictionally engage the air passageway wall to more positively anchor intra-bronchial device 160 without piercing.
- the structure also includes an obstructing member support base 170 .
- Central support structure 109 extends distal of obstructing member 110 , and carries anchor base 161 distal of obstructing member 110 .
- Anchor base 161 carries anchors 112 , 114 , 116 , and 118 .
- the linear plane of anchors 112 , 114 , 116 , and 118 intersects anchor base 161 at anchor angle 163 .
- Anchor angle 163 is selected to optimize anchor deployment force and anchor release.
- the anchors 112 , 114 , 116 , and 118 , and anchor base 161 may be constructed by laser cutting a single piece of hypodermic tubing lengthwise to form the anchors 112 , 114 , 116 , and 118 , and then bending the anchors to form anchor angle 163 .
- Anchor base 161 is secured to central support structure 109 .
- Support members 102 , 103 , 104 , 105 , 106 , and 108 , and the obstructing member support member base 170 may be constructed in a like manner.
- Obstructing member 110 is secured to the obstructing member support base 170 , and alternatively to support members 102 , 103 , 104 , 105 , 106 , and 108 .
- the assembly of obstructing member 110 and support base 170 is secured to central support structure 109 .
- Central support structure 109 may extend proximal of support member base 170 to provide a surface for gripping the intra-bronchial device 160 for removal, and may include an aperture to be engaged by a hooked device.
- FIG. 15 is a perspective view an intra-bronchial device similar to that of FIGS. 12 - 14 anchored in an air passageway. It illustrates pad-shaped anchor ends 122 - 128 of intra-bronchial device 180 deforming and frictionally engaging air passageway wall 130 .
- FIGS. 16 and 17 illustrate a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention.
- FIG. 16 is a perspective view, as the device would appear when fully deployed in an air passageway.
- FIG. 17 is a side view of FIG. 16.
- the support structure 101 of intra-bronchial device 190 includes six support members, with two opposing pairs of support members carrying anchors and each member of a pair being joined together by a retracting member.
- Intra-bronchial device 190 includes a support structure 101 having a central support structure 109 and support members 102 , 103 , 104 , 105 , 106 , and 108 ; four anchors 113 , 114 , 116 , and 118 having anchor ends 123 , 124 , 126 , and 128 , respectively; two “U” shaped retracting members 192 and 194 having an apex 193 and 195 , respectively; and obstructing member 110 .
- Intra-bronchial device 190 is generally similar in construction, operation, placement, and removal to the intra-bronchial device 150 of FIG. 9.
- Support structure 101 is a tubular member, preferably hypodermic needle tubing, or stainless steel, Nitinol, or other suitable material having a memory of its original shape and resiliency to return the material to that shape.
- Support members 102 , 103 , 104 , 105 , 106 , and 108 , and central support structure 109 may be formed by laser cutting a single piece of hypodermic needle tubing lengthwise, and bending the support members to a required shape.
- Support members 102 , 103 , 104 , 105 , 106 , and 108 are generally similar to each other.
- Anchors 113 , 114 , 116 , and 118 are disposed on support members 103 , 104 , 106 , and 108 , respectively, in any manner available in the art. Anchors 113 - 118 are disposed on support members 103 , 104 , 106 , and 108 to be located proximally of obstructing member 110 , and to engage an air passageway wall when intra-bronchial device 190 is deployed.
- “U” shaped retracting member 192 is coupled to support members 103 and 104
- “U” shaped retracting member 194 is coupled to support members 106 and 108
- “U” shaped retracting members 192 and 194 may be constructed of any material suitable for use within a patient, and may or may not be resilient as required by the particular embodiment.
- intra-bronchial device 190 When intra-bronchial device 190 is fully deployed in an air passageway, the “U” shaped retracting members 192 and 194 are arranged opposite each other, and they partially overlap, with the apex of one lying within a space bounded by the “U” shape of the other member. In the deployed configuration, increasing the distance between apex 193 and apex 195 moves support member pairs 103 - 104 and 106 - 108 centrally.
- support members 102 , 103 , 104 , 105 , 106 , and 108 are collapsed centrally into a first configuration. This causes the anchor ends 123 - 124 , and 126 - 128 to move centrally.
- intra-bronchial device 190 When intra-bronchial device 190 is deployed from the catheter lumen, the memory and resiliency of the support member pairs 103 , 104 and 106 , 108 impart a force that moves the anchors 113 and 114 , and 116 and 118 , and their anchor ends 123 and 124 , and 126 and 128 into a second configuration, which is the deployed configuration to engage air passageway wall.
- deployment of intra-bronchial device 190 may include a step of forcibly decreasing the distance between apexes 193 and 195 to forcibly move the anchors 113 and 114 , and 116 and 118 into engagement with the wall of the air passageway.
- anchors 113 and 114 , and 116 and 118 of this embodiment do not include stops, the expansive or peripheral movement of the anchors will be limited by obstructing member 90 . This may limit the piercing of the air passageway wall by anchors 113 and 114 , and 116 and 118 .
- support member pairs 103 , 104 and 106 , 108 may be compressed for insertion into a catheter lumen by a device that increases the distance between apex 193 and apex 195 .
- a device that increases the distance between apex 193 and apex 195 .
- Such a device could be a tool with spreading jaws, or a tapered member inserted between the apexes. The device could be left in engagement after insertion into the catheter, and then withdrawn to allow support member pairs 103 - 104 and 106 - 108 to move apart and engage their anchors into the wall of the air passageway.
- a retractor device is deployed from a catheter lumen to engage apex 193 and 195 , and restrain intra-bronchial device 190 .
- the retractor device may be any device that fits into the space defined by apexes 193 and 195 when the intra-bronchial device 190 is in its fully deployed configuration.
- the retractor device is used to increase the distance between apexes 193 and 195 until anchors 113 - 114 and 116 - 118 , and anchor ends 123 - 124 and 126 - 128 are released from the air passageway wall. This collapses the anchors into to the first configuration for removal.
- Intra-bronchial device 190 is then further collapsed, and drawn into the catheter by pulling on the retractor device. This additionally collapses support structure 101 and obstructing member 110 into the first position so that they may be fully drawn into the catheter. Once drawn into the catheter, intra-bronchial device 190 may be removed from the air passageway and the patient.
- FIG. 18 is a perspective view of an intra-bronchial device 200 with anchors carried on an obstructing member as the device would appear when fully deployed in an air passageway, in accordance with an alternative embodiment of the invention.
- Intra-bronchial device 200 includes an obstructing member 90 , anchors 111 , 112 , 113 , 114 , 115 , 116 , 117 , and 118 (hereafter collectively referred to as anchors 111 - 118 ), and anchor ends 121 , 122 , 123 , 124 , 125 , 126 , 127 , and 128 (hereafter collectively referred to as anchor ends 121 - 128 ).
- Obstructing member 90 may be a single piece made from a collapsible, resilient material, such as silicone, polyurethane, rubber, or foam, and typically will be collapsible to at least one-half of its expanded size.
- obstructing member 90 may include multiple pieces, some being of collapsible material.
- obstructing member 90 may include a membrane carried by a support structure such as described in conjunction with FIGS. 5 - 17 .
- Anchors 111 - 118 comprise material having memory of an original shape, and resiliency to return the material to that shape, and typically have a diameter small enough that penetration through an air passageway wall may not adversely effect a patient.
- Anchors 111 - 118 may be 0.003-inch diameter 316 stainless steel with a wire spring temper, Nitinol, or other resilient material.
- Anchor ends 121 - 128 may be shaped to promote or control piercing of the air passageway wall.
- the length of the anchors 111 - 118 may be limited to allow the anchors 111 - 118 to penetrate into but not through the air passageway wall. In the preferred embodiment illustrated in FIG.
- the anchors include four pieces of material pushed through obstructing member 90 .
- the four pieces would lie in approximately the same cross-sectional plane, and cross each other at approximately the centerline of obstructing member 90 , with approximately equal portions of the anchor material projecting from opposite sides of the obstructing member 90 .
- anchors 112 and 116 would be opposite portions of a single piece of material.
- Anchors 111 - 118 may be secured to control their position.
- a centerline opening may be made in obstructing member 90 exposing the several pieces of anchoring material. The several pieces of material could them be joined together, or to obstructing member 90 , at a location within the centerline opening by an adhesive, crimping, welding, or other method of mechanically joining materials known to those in the art.
- the anchors may be formed by individual pieces of material.
- the individual pieces of material may be coupled to obstructing member 90 either at its periphery, or within its periphery.
- FIG. 19 is a partial longitudinal sectional view of the intra-bronchial device of FIG. 18 collapsed and located into a delivery catheter lumen for placement in an air passageway to collapse a lung portion associated with the air passageway, in accordance with the present invention.
- Intra-bronchial device 200 is generally placed in an air passageway as described in FIGS. 2 and 3.
- intra-bronchial device 200 is collapsed and placed into delivery catheter lumen 70 .
- Obstructing member 90 is collapsed into approximately a cylindrical shape.
- Anchors 111 - 118 are collapsed to a position in proximity to or against the outer periphery of collapsed obstructing member 90 .
- Intra-bronchial device 200 is inserted into catheter lumen 70 , the distal end of which is typically already placed in the air passageway 50 as generally illustrated in FIG. 3.
- intra-bronchial device 200 is advanced through the catheter lumen 70 into the air passageway to where it is to be deployed. Once the point of deployment is reached, intra-bronchial device 200 is expelled from catheter lumen 70 , and assumes a deployed shape as illustrated in FIG. 18.
- FIG. 20 is a perspective view of the intra-bronchial device of FIG. 18 in its fully deployed and anchored state in an air passageway, in accordance with the present invention.
- Intra-bronchial device 200 is illustrated after having been expelled from the catheter lumen in substantially the manner described in conjunction with FIG. 3, and having deployed anchors 112 and 116 by piercing into and through air passageway wall 130 of air passageway 50 . The piercing engages the air passageway wall and anchors intra-bronchial device 200 within the air passageway 50 .
- the resiliency of obstructing member 90 imparts a force to expand the obstructing member 90 from the collapsed state to a deployed state. In its deployed state, obstructing member 90 forms a contact zone 129 with the wall 130 of air passageway 50 preventing air from being inhaled into the lung portion.
- the resiliency of the anchor members 111 - 118 moves them from their collapsed state illustrated in FIG. 19 to their deployed state.
- the resiliency of obstructing member 90 may assist anchor members 111 - 118 in deployment. In the alternative embodiment where the length of anchors 111 - 118 is limited to allow the anchors 111 - 118 to penetrate into but not through the air passageway wall, the anchors penetrate the air passageway wall 150 in the manner illustrated in FIG. 7.
- FIGS. 21 - 24 are side views showing an embodiment of the present invention for removing the intra-bronchial device 200 from air passageway 50 .
- the preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect of intra-bronchial device 200 .
- the preclusion of air by the embodiment illustrated in FIG. 18 may be eliminated by releasing anchors 111 - 118 from the air passageway wall 130 .
- a bronchoscope 74 is placed in proximity to intra-bronchial device 200 in the air passageway 50 .
- a catheter 70 having an internal lumen 71 is fed into the bronchoscope 74 and advanced to the proximal end of the intra-bronchial device 200 .
- a retractor device, such as biopsy forceps 76 capable of gripping a portion of intra-bronchial device 200 , is inserted in the catheter 70 of the bronchoscope 74 and advanced to the intra-bronchial device 200 .
- the jaws of the forceps 76 are used to engage a portion of the obstructing member 90 .
- the engagement may collapse a portion of obstructing member 90 .
- the engagement with the obstructing member 90 is maintained and obstructing member 90 is drawn toward the catheter lumen 71 by the forceps 76 .
- the drawing action releases anchors 111 - 118 from air passageway wall 130 .
- the intra-bronchial device 200 is then drawn into the catheter lumen 71 with the forceps 76 .
- the collapsed device 200 now fully enters the catheter lumen 71 for removal from the patient.
- FIG. 25 is a perspective view of an intra-bronchial device with anchors projecting from a periphery of an obstructing member as the device would appear when fully deployed, in accordance with an alternative embodiment of the present invention.
- the intra-bronchial device 210 includes support members 102 , 104 , 106 , and 108 ; an obstructing member 110 ; “s” shaped bends 212 , 214 , 216 , and 218 ; and anchors 112 , 114 , 116 , and 118 .
- the support members 102 , 104 , 106 , and 108 form a support structure carrying obstructing member 110 , and include anchors 112 , 114 , 116 , and 118 ; and anchor ends 122 , 124 , 126 , and 128 , respectively.
- the support members 102 , 104 , 106 , and 108 may be tubular members, and are preferably hypodermic needle tubing.
- Support members 102 , 104 , 106 , and 108 form a support structure by being joined together at a location toward the distal portion of intra-bronchial device 210 . They may be joined by a mechanical method, such as by crimping, or by other methods such as adhesive or welding.
- two support members may be formed from a single piece of material by bending it in the middle.
- Support members 102 , 104 , 106 , and 108 are generally similar to each other.
- the support members are preferably formed of stainless steel, Nitinol, or other suitable material having a memory of its original shape, and resiliency to return the material to that shape.
- Anchors 112 , 114 , 116 , and 118 are extensions of support members 102 , 104 , 106 , and 108 .
- the anchors are formed by forming “s” shaped bends 212 , 214 , 216 , and 218 in proximal portions of the support members.
- Anchor ends 122 , 124 , 126 , and 128 may be shaped to promote piercing the air passageway wall.
- the obstructing member 110 is carried on the support structure formed by support members 102 , 104 , 106 , and 108 .
- Obstructing member 110 includes a flexible membrane open in the proximal direction and which may be formed of silicone or polyurethane, for example.
- the obstructing member 110 includes openings 222 , 224 , 226 , and 228 sized to sealingly admit the “s” shaped bends 212 , 214 , 216 , and 218 of support members 102 , 104 , 106 , and 108 , respectively.
- FIG. 26 illustrates the placement and securing of the obstructing member 110 to support member 102 at “s” bend 212 .
- Obstructing member 110 is fitted over the anchor end 122 and anchor 112 at opening 222 .
- Obstructing member 110 engages the peripheral apex of the “s” shaped bend 212 , and thus secures it.
- the obstructing member 110 is placed and secured to the other “s” bends 214 , 216 , and 218 in a similar manner.
- Obstructing member 110 may be loosely carried on support members 102 , 104 , 106 , and 108 such that it expands on inhalation to form a seal against a wall of the air passageway, and contracts on exhalation to allow air and mucociliary transport from the collapsed lung. This provides a one-way valve function.
- FIG. 27 is a perspective view of the intra-bronchial device of FIG. 25 fully deployed and anchored in an air passageway, in accordance with the present invention.
- Intra-bronchial device 210 is illustrated after having been expelled from the catheter lumen in substantially the manner described in conjunction with FIG. 3, and having deployed anchors 112 , 114 , 116 , and 118 by piercing into air passageway wall 130 of air passageway 50 . The piercing engages the air passageway wall and anchors intra-bronchial device 210 within the air passageway 50 .
- Deploying obstructing member 210 is much like opening an umbrella. Upon deployment, the memory and resiliency of the support members 102 , 104 , 106 , and 108 , expand obstructing member 210 . The expanded obstructing member 210 forms a contact zone 129 with the wall 130 of the air passageway 50 to prevent air from being inhaled into the lung portion to collapse the lung portion.
- the memory and resiliency of the support members 102 , 104 , 106 , and 108 impart a force on the anchor ends 122 , 124 , 126 , and 128 , and urge the anchors 112 , 114 , 116 , and 118 to engage air passageway wall 130 by piercing.
- the anchors pierce into and become embedded in the wall 130 of the air passageway 50 , preferably without projecting through the wall 130 . Stops may be incorporated into the anchors to limit piercing of the wall 130 .
- the “s” bends 212 , 214 , 216 , and 218 may form a stop.
- the preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect of intra-bronchial device 210 .
- the preclusion of air by the embodiment illustrated in FIGS. 25 - 27 may be eliminated by releasing anchors 112 , 114 , 116 , and 118 from the air passageway wall 130 .
- the anchors are released and the intra-bronchial device 210 is removed from air passageway 50 in substantially the same manner described in conjunction with FIGS. 7 , and 21 - 24 .
- the forceps are used to engage a portion of intra-bronchial device 210 , and maneuvered to release anchors 112 , 114 , 116 , and 118 from the air passageway wall 130 .
- Intra-bronchial device 210 is then drawn into the catheter for removal from the patient.
- the obstructing effect may be eliminated by engaging the obstructing member 210 , releasing it from the support members 102 , 104 , 106 , and 108 , and drawing obstructing member 110 into the catheter for removal from the patent.
Abstract
An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
Description
- The present invention is generally directed to a removable anchored device, system, and method for treating Chronic Obstructive Pulmonary Disease (COPD). The present invention is more particularly directed to providing an anchored intra-bronchial obstruction that may be removable.
- COPD has become a major cause of morbidity and mortality in the United States over the last three decades. COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.
- The incidence, prevalence, and health-related costs of COPD are on the rise. Mortality due to COPD is also on the rise. In 1991, COPD was the fourth leading cause of death in the United States and had increased 33% since 1979. COPD affects the patient's whole life. It has three main symptoms: cough; breathlessness; and wheeze. At first, breathlessness may be noticed when running for a bus, digging in the garden, or walking uphill. Later, it may be noticed when simply walking in the kitchen. Over time, it may occur with less and less effort until it is present all of the time. COPD is a progressive disease and currently has no cure. Current treatments for COPD include the prevention of further respiratory damage, pharmacotherapy, and surgery. Each is discussed below.
- The prevention of further respiratory damage entails the adoption of a healthy lifestyle. Smoking cessation is believed to be the single most important therapeutic intervention. However, regular exercise and weight control are also important. Patients whose symptoms restrict their daily activities or who otherwise have an impaired quality of life may require a pulmonary rehabilitation program including ventilatory muscle training and breathing retraining. Long-term oxygen therapy may also become necessary.
- Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled beta-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, ipratropium bromide may be indicated. Further, courses of steroids, such as corticosteroids, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pneumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.
- About 40 years ago, it was first postulated that the tethering force that tends to keep the intrathoracic airways open was lost in emphysema and that by surgically removing the most affected parts of the lungs, the force could be partially restored. Although the surgery was deemed promising, the lung volume reduction surgery (LVRS) procedure was abandoned. LVRS was later revived. In the early 1990's, hundreds of patients underwent the procedure. However, the procedure has fallen out of favor when Medicare stopping reimbursing for LVRS. Unfortunately, data is relatively scarce and many factors conspire to make what data exists difficult to interpret. The procedure is currently under review in a controlled clinical trial. However, what data does exist tends to indicate that patients benefited from the procedure in terms of an increase in forced expiratory volume, a decrease in total lung capacity, and a significant improvement in lung function, dyspnea, and quality of life. Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory muscaulature, and improved right ventricular filling.
- Lastly, lung transplantation is also an option. Today, COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.
- There is a need for additional non-surgical options for permanently treating COPD without surgery. A promising new therapy includes non-surgical apparatus and procedures for lung volume reduction by permanently obstructing the air passageway that communicates with the portion of the lung to be collapsed. The therapy includes placing an obstruction in the air passageway that prevents inhaled air from flowing into the portion of the lung to be collapsed. Lung volume reduction with concomitant improved pulmonary function may be obtained without the need for surgery. The effectiveness of obstructions may be enhanced if it is anchored in place. The effectiveness may also be enhanced if the obstruction is removable. However, no readily available apparatus and method exists for anchoring the obstruction, and for removal if required.
- In view of the foregoing, there is a need in the art for a new and improved apparatus and method for permanently obstructing an air passageway that is anchored in place, and that may be removed if required. The present invention is directed to a device, system, and method that provide such an improved apparatus and method for treating COPD.
- The present invention provides an anchored intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion to collapse the lung portion, and an anchor that anchors the obstruction device within the air passageway when the anchor is deployed. The anchor may engage the air passageway wall, and may pierce into the air passageway wall. The obstructing member and the anchor may be simultaneously deployable. The anchor may be releasable from the air passageway for removal of the obstructing member. A portion of the intra-bronchial device may be collapsible. The anchor may be releasable from the air passageway for removal of the obstructing member by collapsing a portion of the obstructing member, or by drawing the obstructing member proximally. The anchor may include a resilient material for imparting a force against the air passageway to deform the air passageway to more positively anchor the obstructing member. The anchor may comprise material having memory of an original shape, and resiliency to return the material to that shape. The obstructing member may comprise material having memory of an original shape, and resiliency to return the material to that shape. The obstructing member may be a one-way valve.
- In another embodiment of the present invention, a method of reducing the size of a lung by collapsing a portion of the lung is provided. The method includes the step of providing an intra-bronchial device comprising an obstructing member which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and an anchor that anchors the obstructing member when the anchor is deployed. The method further includes the steps of placing the obstructing member in the air passageway, and deploying the anchor. The anchor may be releasable for removal of the obstructing member. The obstructing member may form a one-way valve. A portion of the obstructing member may be collapsible.
- In a further embodiment of the present invention, a method of reducing the size of a lung by collapsing a portion of the lung with a removable device is provided. The method includes the step of providing an intra-bronchial device and an obstructing member that is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and an anchor that anchors the obstructing member when the anchor is deployed. The method includes the additional steps of placing the obstructing member in the air passageway, deploying an anchor, and removing the obstructing member. The anchor is releasable from the air passageway for removal of the intra-bronchial device, and the step of removing the obstructing member includes the further step of releasing the anchor. The obstructing member may form a one-way valve. At least a portion of the obstructing member may be collapsible, and the step of removing the obstructing member includes the further step of collapsing a portion of the obstructing member.
- In yet another embodiment of the present invention, an air passageway-obstructing device is provided. The obstructing device includes obstructing means for obstructing air flow within the air passageway, and anchoring means to anchor the air passageway obstructing device within the air passageway.
- In yet a further embodiment of the present invention, an air passageway-obstructing device is provided that includes obstructing means for obstructing air flow within the air passageway, and anchoring means to anchor the air passageway obstructing device within the air passageway, the anchoring means being releasable for removal of the obstructing means from the air passageway.
- These and various other features as well as advantages which characterize the present invention will be apparent from a reading of the following detailed description and a review of the associated drawings.
- The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like referenced numerals identify like elements, and wherein:
- FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system;
- FIG. 2 is a sectional view similar to FIG. 1, but illustrating a respiratory system suffering from COPD and the execution of a first step in treating the COPD condition by reducing the size of a lung portion in accordance with the present invention;
- FIG. 3 is perspective view, partially in section, and to an enlarged scale, illustrating an intermediate step in the treatment;
- FIG. 4 is a perspective view of a conduit that may be utilized in practicing the present invention;
- FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention;
- FIG. 6 is a partial section view of the device of FIG. 5 showing additional details of the support structure;
- FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway;
- FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention;
- FIG. 9 is a perspective view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention;
- FIG. 10 is a side view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention;
- FIG. 11 is an end view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention;
- FIG. 12 is a perspective view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention;
- FIG. 13 is a side view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention;
- FIG. 14 is an end view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention;
- FIG. 15 is a perspective view an intra-bronchial device similar to that of FIGS.12-14 anchored in an air passageway;
- FIG. 16 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention;
- FIG. 17 is a side view of the device of FIG. 16;
- FIG. 18 is a perspective view of a device in its deployed state with anchors carried on an obstructing member, in accordance with an alternative embodiment of the invention;
- FIG. 19 is a partial longitudinal sectional view of the device of FIG. 18 in a collapsed state and located into a lumen for placement in an air passageway;
- FIG. 20 is a perspective view of the device of FIG. 18 in its deployed and anchored state in an air passageway, in accordance with the present invention;
- FIG. 21 is a side view of an initial step in removing the device of FIG. 18 from an air passageway;
- FIG. 22 is a side view of an intermediate step in removing the device of FIG. 18 from an air passageway;
- FIG. 23 is a side view of another intermediate step in removing the device of FIG. 18 from an air passageway;
- FIG. 24 is a side view illustrating the collapse of the device of FIG. 18 during its removal from an air passageway;
- FIG. 25 is a perspective view of a device in its deployed state with anchors carried on the obstructing member, in accordance with an alternative embodiment of the present invention;
- FIG. 26 illustrates the placement and securing of the obstructing member of the device of FIG. 25 to a support member; and
- FIG. 27 is a perspective view of the intra-bronchial device of FIG. 25 fully deployed and anchored in an air passageway, in accordance with the present invention.
- In the following detailed description of exemplary embodiments of the invention, reference is made to the accompanying drawings that form a part hereof. The detailed description and the drawings illustrate how specific exemplary embodiments by which the invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention. It is understood that other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the present invention. The following detailed description is therefore not to be taken in a limiting sense, and the scope of the present invention is defined by the appended claims.
- Throughout the specification and claims, the following terms take the meanings explicitly associated herein unless the context clearly dictates otherwise. The meaning of “a”, “an”, and “the” include plural references. The meaning of “in” includes “in” and “on.” Referring to the drawings, like numbers indicate like parts throughout the views. Additionally, a reference to the singular includes a reference to the plural unless otherwise stated or inconsistent with the disclosure herein.
- Additionally, throughout the specification, claims, and drawings, the term “proximal” means nearest the trachea, and “distal” means nearest the bronchioles.
- Briefly stated, an aspect of the invention provides an anchored intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway. A further aspect of the invention provides removability of the intra-bronchial device, either by releasing the anchors for removal of the entire device or by separating the obstructing member and removing it.
- FIG. 1 is a sectional view of a healthy respiratory system. The
respiratory system 20 resides within thethorax 22 that occupies a space defined by thechest wall 24 and thediaphragm 26. - The
respiratory system 20 includes thetrachea 28, theleft mainstem bronchus 30, theright mainstem bronchus 32, thebronchial branches sub-branches respiratory system 20 further includesleft lung lobes right lung lobes - Characteristic of a healthy respiratory system is the arched or inwardly
arcuate diaphragm 26. As the individual inhales, thediaphragm 26 straightens to increase the volume of thethorax 22. This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air. When the individual exhales, the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes. - In contrast to the healthy respiratory system of FIG. 1, FIG. 2 illustrates a respiratory system suffering from COPD. Here it may be seen that the
lung lobes diaphragm 26 is not arched but substantially straight. Hence, this individual is incapable of breathing normally by movingdiaphragm 28. Instead, in order to create the negative pressure inthorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths. - It has been found that the
apex portions upper lung lobes upper lung lobe 56. However, as will be appreciated by those skilled in the art, the present invention may be applied to any lung portion without departing from the present invention. As will be further appreciated by those skilled the in art, the present invention may be used with any type of obstructing member to provide an anchored obstructing device, which may be removed. The inventions disclosed and claimed in U.S. Pat. Nos. 6,258,100 and 6,293,951, both of which are incorporated herein by reference, provide an improved therapy for treating COPD by obstructing an air passageway using an intra-bronchial valve or plug. The present invention may be used with the apparatus, system, and methods of these patents as will be briefly described in conjunction with the disclosure of the preferred embodiments of the present invention. - The insertion of an obstructing member treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing the surgery. The treatment contemplates permanent collapse of a lung portion. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling. The present invention supports the use of intra-bronchial plugs to treat COPD by anchoring the obstruction device in the air passageway. The present invention further supports the use of intra-bronchial plugs by providing for their removal if necessary. Use of anchors can allow the obstructing member to be relatively loosely fitted against the air passageway wall, which may provide increased mucociliary transport of mucus and debris out of the collapsed lung portion.
- FIG. 2 also illustrates a step in COPD treatment using an obstructing member. Treatment is initiated by feeding a conduit or
catheter 70 down thetrachea 28, into theright mainstem bronchus 32, into thebronchial branch 42 and into and terminating within the sub-branch 50. The sub-branch 50 is the air passageway that communicates with thelung portion 66 to be treated, and is also referred to herein asair passageway 50. Thecatheter 70 is preferably formed of flexible material such as polyethylene. Also, thecatheter 70 is preferably preformed with abend 72 to assist the feeding of the catheter from theright mainstem bronchus 32 into thebronchial branch 42. - FIG. 3 illustrates a further step in a method for placing an obstructing
member 90 in a bronchial sub-branch using a catheter. The invention disclosed herein is not limited to use with the particular method illustrated herein.Catheter 70 includes an optionalinflatable sealing member 74 for use with a vacuum to collapselung portion 66 prior to insertion of obstructingmember 90. The obstructingmember 90 may be formed of resilient or collapsible material to enable the obstructingmember 90 to be fed through thecatheter 70 in a collapsed state. The obstructingmember 90 and its anchors (not shown) are collapsed and fed into thecatheter 70. Thestylet 92 is used to push the obstructingmember 90 to theend 77 of thecatheter 70 for placing the obstructingmember 90 within theair passageway 50 adjacent to thelung portion 66 to be permanently collapsed. Optional sealingmember 74 is withdrawn after obstructingmember 90 is inserted. - A function of the intra-bronchial device disclosed and claimed in this specification, including the detailed description and the claims, is described in terms of collapsing a lung portion associated with an air passageway. In some lungs, a portion of a lung may receive air from collateral air passageways. Obstructing one of the collateral air passageways may reduce the volume of the lung portion associated with the air passageway, but not completely collapse the lung portion as that term may be generally understood. As used herein, the meaning of “collapse” includes both a complete collapse of a lung portion and a partial collapse of a lung portion.
- Once deployed, the obstructing member precludes inhaled air from entering the lung portion to be collapsed. In accordance with the present invention, it is preferable that the obstructing member takes the form of a one-way valve. In addition to precluding inhaled air from entering the lung portion, the member further allows air within the lung portion to be exhaled. This results in more rapid collapse of the lung portion. In addition, anchoring obstructing members that preclude both inhaled and exhaled airflow are contemplated as within the scope of the invention.
- FIG. 4 illustrates the obstructing device in place within
air passageway 50. Obstructingmember 90 has expanded upon placement in theair passageway 50 to seal theair passageway 50. This causes thelung portion 66 to be maintained in a permanently collapsed state. The obstructingmember 90 may be any shape suitable for accomplishing its purpose, and may be a solid material or a membrane. - More specifically, the obstructing
member 90 has anouter dimension 91, and when expanded, enables a contact zone with the air passagewayinner dimension 51. This seals the air passageway upon placement of the obstructingmember 90 in theair passageway 50 for maintaining thelung portion 66 in the collapsed state. - Alternatively, the
lung portion 66 may be collapsed using vacuum prior to placement of obstructingmember 90, or sealing theair passageway 50 with obstructingmember 90 may collapse it. Over time, the air within thelung portion 66 will be absorbed by the body and result in the collapse oflung portion 66. Alternatively, obstructingmember 90 may include the function of a one-way valve that allows air to escape fromlung portion 66.Lung portion 66 will then collapse, and the valve will prevent air from being inhaled. - FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention.
Intra-bronchial device 100 includes asupport structure 101, acentral support structure 109;support members anchors member 110. - The
support structure 101 of intra-bronchial device includescentral support structure 109, andsupport members support members anchors Central support structure 109 is a tubular member, preferably hypodermic needle tubing.Support members central support structure 109, such as by crimping, or by other methods such as adhesive or welding.Support members -
Anchors support members - Obstructing
member 110 is carried on thesupport structure 101, and includes a flexible membrane open in the proximal direction and which may be formed of silicone or polyurethane, for example. The obstructingmember 110 is secured to thecentral support structure 109, and may be additionally secured to the support members at itslarger diameter 91. It may be secured by adhesive, or other manner known in the art. Obstructingmember 110 may be loosely carried onsupport members - FIG. 6 is a partial section view of the device of FIG. 5 showing additional detail of the support structure. The linear cross-section view of FIG. 6 exposes the arrangement of
support members support members support members member 110 is carried oncentral support structure 109.Support members central support structure 109, and arranged to loosely support to obstructingmember 110 at itslarger diameter 91. This allows obstructingmember 110 to expand on inhalation and seal at thecontact zone 129, and to partially contract on exhalation to allow exhalation of air and mucociliary transport. In an alternative embodiment,support members member 110, and the expansion and contraction of obstructingmember 110 is governed by its elasticity. - FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway.
Intra-bronchial device 100 is illustrated withanchors air passageway wall 130 ofair passageway 50. This anchors theintra-bronchial device 100 in place. -
Intra-bronchial device 100 is collapsible for insertion into an internal lumen of a catheter. At least thesupport members member 110, may be collapsed.Intra-bronchial device 100 is inserted into the catheter lumen, which is typically already placed in theair passageway 50 as generally illustrated in FIG. 3. Using the stylet,intra-bronchial device 100 is advanced down the catheter lumen into theair passageway 50 to where the device is to be deployed. Once the point of deployment is reached,intra-bronchial device 100 is expelled from the catheter and assumes its deployed shape as illustrated in FIG. 5. Upon deployment, obstructingmember 110 expands to form acontact zone 129 with thewall 130 of theair passageway 50 to prevent air from being inhaled into the lung portion to collapse the lung portion. Simultaneously upon deployment, the memory and resiliency of thesupport members anchors air passageway wall 130 by piercing. The anchors pierce into and become embedded in thewall 130 of theair passageway 50, preferably without projecting through thewall 130. Stops may be incorporated into the anchors to limit piercing of thewall 130. For example, the bend between the support member and the anchor may form a stop. - The preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect of
intra-bronchial device 100. The preclusion of air by the embodiment illustrated in FIGS. 5-7 may be eliminated by releasinganchors air passageway wall 130. The anchors may be released by inserting a catheter intoair passageway 50 in proximity tointra-bronchial device 100. A retractor device, such as biopsy forceps, capable of gripping a portion ofintra-bronchial device 100 is inserted in the catheter. The forceps are used to engage a portion of thesupport structure 101 ofintra-bronchial device 100, and draw it toward the catheter. The drawing action releases anchors 112, 114, 116, and 118 fromair passageway wall 130. Theintra-bronchial device 110 is then drawn into the catheter with the forceps, causing thesupport structure 101 and obstructingmember 110 to collapse. Thecollapsed device 100 now fully enters the catheter lumen for removal from the patient. Alternatively, the obstructing effect may be eliminated by grabbing the obstructingmember 110, releasing it from thesupport structure 101, and removing obstructingmember 110 from the patient. - FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention. The
anchors intra-bronchial device 140 are carried on portions ofsupport members central support structure 109. The support members are gathered together and carried by thecentral support structure 109. Other than theanchors support members intra-bronchial device 140 is substantially similar in construction, operation, and removal as theintra-bronchial device 100 of FIG. 5. - When
intra-bronchial device 140 is compressed for insertion into the catheter lumen for placement in the air passageway, theanchors member 110, and anchors 112, 114, 116, and 118 thereby folded toward obstructingmember 110. Whenintra-bronchial device 100 is deployed from the catheter lumen, the memory and resiliency of thesupport members anchors air passageway wall 130. This is the deployed configuration illustrated in FIG. 8. For removal, drawingintra-bronchial device 140 toward the catheter causes the anchor ends 122, 124, 126, and 128 to move away from obstructingmember 110 to a third configuration.Anchors member 110 and are released from engagement withair passageway wall 130 for removal of theintra-bronchial device 140. In an alternative embodiment, theanchors central support structure 109, instead of being formed from distal portions ofsupport members - FIGS.9-11 illustrate an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention. FIG. 9 is a perspective view, FIG. 10 is a side view, and FIG. 11 is an end view of the device.
Intra-bronchial device 150 is generally similar in construction, operation, placement, and removal to theintra-bronchial device 100 of FIG. 5. Its structure has six support members and three anchors, with anchor stops.Anchors stops Intra-bronchial device 150 also includes ananchor base 160, ananchor base aperture 165,anchor base angle 163, andadditional support members -
Central support structure 109 extends both proximal and distal of obstructingmember 110, and carriesanchor base 161 proximal of obstructingmember 110, carriesanchors anchor base aperture 165. The linear plane ofanchors anchor base 161 atanchor base angle 163.Anchor base angle 163 is selected to optimize anchor deployment force and anchor release.Stops - In operation, when
intra-bronchial device 150 is compressed for insertion into the catheter lumen for placement in the air passageway, anchors 112, 114, and 116 are collapsed into a first configuration. In the first configuration, the anchor ends 122, 124, and 126 are moved toward obstructingmember 110, thereby decreasinganchor base angle 163 and folding anchors 112, 114, and 116 toward obstructingmember 110. The anchor ends and the anchors may be moved by sliding a catheter or hollow member overanchor base 161 and toward obstructingmember 110. Whenintra-bronchial device 150 is deployed from the catheter lumen, the memory and resiliency of theanchors anchor angle 163, andanchor base 161 impart a force that moves the anchor members into a second configuration, which is the deployed configuration, to engageair passageway wall 130. The second or deployed configuration is illustrated in FIGS. 9-11.Stops - For removal, a retractor device is deployed from a catheter to engage
anchor base 161 and restrainintra-bronchial device 150. The retractor device may be a biopsy forceps to engageanchor base 161, or a hooked device to engageanchor base aperture 165. A catheter is then moved distally overanchor base 161, and in contact withanchors anchors intra-bronchial device 150 is restrained atanchor base 161. This releases theanchors Intra-bronchial device 150 is then further drawn into the catheter by pulling on the retractor device used to engageanchor base 161. This collapsessupport structure 101 and obstructingmember 110 so that they may be fully drawn into the catheter. Once drawn into the catheter,intra-bronchial device 160 may be removed from the air passageway and the patient. - FIGS.12-14 illustrate an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention. FIG. 12 is a perspective view, FIG. 13 is a side view, and FIG. 14 is an end view.
Intra-bronchial device 160 is generally similar in construction, placement, and operation to theintra-bronchial device 150 of FIGS. 9-11.Intra-bronchial device 160 is removed in the manner described in conjunction with FIG. 7. However,Intra-bronchial device 160 differs fromintra-bronchial device 150 in that the structure includes four distal anchors with anchor ends 122, 124, 126, and 128 shaped into pads that deform and frictionally engage the air passageway wall to more positively anchorintra-bronchial device 160 without piercing. The structure also includes an obstructingmember support base 170. -
Central support structure 109 extends distal of obstructingmember 110, and carriesanchor base 161 distal of obstructingmember 110.Anchor base 161 carriesanchors anchors anchor base 161 atanchor angle 163.Anchor angle 163 is selected to optimize anchor deployment force and anchor release. Theanchors anchor base 161 may be constructed by laser cutting a single piece of hypodermic tubing lengthwise to form theanchors anchor angle 163.Anchor base 161 is secured tocentral support structure 109.Support members support member base 170 may be constructed in a like manner. Obstructingmember 110 is secured to the obstructingmember support base 170, and alternatively to supportmembers member 110 andsupport base 170 is secured tocentral support structure 109.Central support structure 109 may extend proximal ofsupport member base 170 to provide a surface for gripping theintra-bronchial device 160 for removal, and may include an aperture to be engaged by a hooked device. - FIG. 15 is a perspective view an intra-bronchial device similar to that of FIGS.12-14 anchored in an air passageway. It illustrates pad-shaped anchor ends 122-128 of
intra-bronchial device 180 deforming and frictionally engagingair passageway wall 130. - FIGS. 16 and 17 illustrate a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention. FIG. 16 is a perspective view, as the device would appear when fully deployed in an air passageway. FIG. 17 is a side view of FIG. 16. In a preferred embodiment, the
support structure 101 ofintra-bronchial device 190 includes six support members, with two opposing pairs of support members carrying anchors and each member of a pair being joined together by a retracting member.Intra-bronchial device 190 includes asupport structure 101 having acentral support structure 109 andsupport members anchors members member 110. -
Intra-bronchial device 190 is generally similar in construction, operation, placement, and removal to theintra-bronchial device 150 of FIG. 9.Support structure 101 is a tubular member, preferably hypodermic needle tubing, or stainless steel, Nitinol, or other suitable material having a memory of its original shape and resiliency to return the material to that shape.Support members central support structure 109 may be formed by laser cutting a single piece of hypodermic needle tubing lengthwise, and bending the support members to a required shape.Support members Anchors support members support members member 110, and to engage an air passageway wall whenintra-bronchial device 190 is deployed. - “U” shaped retracting
member 192 is coupled to supportmembers member 194 is coupled to supportmembers members intra-bronchial device 190 is fully deployed in an air passageway, the “U” shaped retractingmembers apex 193 and apex 195 moves support member pairs 103-104 and 106-108 centrally. - In operation, when
intra-bronchial device 190 is compressed for insertion into a catheter lumen and placement in an air passageway,support members - When
intra-bronchial device 190 is deployed from the catheter lumen, the memory and resiliency of the support member pairs 103,104 and 106,108 impart a force that moves theanchors intra-bronchial device 190 may include a step of forcibly decreasing the distance betweenapexes anchors anchors member 90. This may limit the piercing of the air passageway wall byanchors - In an alternative embodiment, support member pairs103,104 and 106,108 may be compressed for insertion into a catheter lumen by a device that increases the distance between
apex 193 andapex 195. Such a device could be a tool with spreading jaws, or a tapered member inserted between the apexes. The device could be left in engagement after insertion into the catheter, and then withdrawn to allow support member pairs 103-104 and 106-108 to move apart and engage their anchors into the wall of the air passageway. - For removal, a retractor device is deployed from a catheter lumen to engage apex193 and 195, and restrain
intra-bronchial device 190. The retractor device may be any device that fits into the space defined byapexes intra-bronchial device 190 is in its fully deployed configuration. The retractor device is used to increase the distance betweenapexes Intra-bronchial device 190 is then further collapsed, and drawn into the catheter by pulling on the retractor device. This additionally collapsessupport structure 101 and obstructingmember 110 into the first position so that they may be fully drawn into the catheter. Once drawn into the catheter,intra-bronchial device 190 may be removed from the air passageway and the patient. - FIG. 18 is a perspective view of an
intra-bronchial device 200 with anchors carried on an obstructing member as the device would appear when fully deployed in an air passageway, in accordance with an alternative embodiment of the invention.Intra-bronchial device 200 includes an obstructingmember 90, anchors 111, 112, 113, 114, 115, 116, 117, and 118 (hereafter collectively referred to as anchors 111-118), and anchor ends 121, 122, 123, 124, 125, 126, 127, and 128(hereafter collectively referred to as anchor ends 121-128). - Obstructing
member 90 may be a single piece made from a collapsible, resilient material, such as silicone, polyurethane, rubber, or foam, and typically will be collapsible to at least one-half of its expanded size. In an alternative embodiment, obstructingmember 90 may include multiple pieces, some being of collapsible material. In a further alternative embodiment, obstructingmember 90 may include a membrane carried by a support structure such as described in conjunction with FIGS. 5-17. - Anchors111-118 comprise material having memory of an original shape, and resiliency to return the material to that shape, and typically have a diameter small enough that penetration through an air passageway wall may not adversely effect a patient. Anchors 111-118 may be 0.003-inch diameter 316 stainless steel with a wire spring temper, Nitinol, or other resilient material. Anchor ends 121-128 may be shaped to promote or control piercing of the air passageway wall. In an alternative embodiment, the length of the anchors 111-118 may be limited to allow the anchors 111-118 to penetrate into but not through the air passageway wall. In the preferred embodiment illustrated in FIG. 18, the anchors include four pieces of material pushed through obstructing
member 90. The four pieces would lie in approximately the same cross-sectional plane, and cross each other at approximately the centerline of obstructingmember 90, with approximately equal portions of the anchor material projecting from opposite sides of the obstructingmember 90. In this embodiment, for example, anchors 112 and 116 would be opposite portions of a single piece of material. Anchors 111-118 may be secured to control their position. For example, a centerline opening may be made in obstructingmember 90 exposing the several pieces of anchoring material. The several pieces of material could them be joined together, or to obstructingmember 90, at a location within the centerline opening by an adhesive, crimping, welding, or other method of mechanically joining materials known to those in the art. - In an alternative embodiment, the anchors may be formed by individual pieces of material. The individual pieces of material may be coupled to obstructing
member 90 either at its periphery, or within its periphery. - FIG. 19 is a partial longitudinal sectional view of the intra-bronchial device of FIG. 18 collapsed and located into a delivery catheter lumen for placement in an air passageway to collapse a lung portion associated with the air passageway, in accordance with the present invention.
Intra-bronchial device 200 is generally placed in an air passageway as described in FIGS. 2 and 3. - More specifically,
intra-bronchial device 200 is collapsed and placed intodelivery catheter lumen 70. Obstructingmember 90 is collapsed into approximately a cylindrical shape. Anchors 111-118 are collapsed to a position in proximity to or against the outer periphery of collapsed obstructingmember 90.Intra-bronchial device 200 is inserted intocatheter lumen 70, the distal end of which is typically already placed in theair passageway 50 as generally illustrated in FIG. 3. Usingstylet 92,intra-bronchial device 200 is advanced through thecatheter lumen 70 into the air passageway to where it is to be deployed. Once the point of deployment is reached,intra-bronchial device 200 is expelled fromcatheter lumen 70, and assumes a deployed shape as illustrated in FIG. 18. - FIG. 20 is a perspective view of the intra-bronchial device of FIG. 18 in its fully deployed and anchored state in an air passageway, in accordance with the present invention.
Intra-bronchial device 200 is illustrated after having been expelled from the catheter lumen in substantially the manner described in conjunction with FIG. 3, and having deployedanchors air passageway wall 130 ofair passageway 50. The piercing engages the air passageway wall and anchorsintra-bronchial device 200 within theair passageway 50. - The resiliency of obstructing
member 90 imparts a force to expand the obstructingmember 90 from the collapsed state to a deployed state. In its deployed state, obstructingmember 90 forms acontact zone 129 with thewall 130 ofair passageway 50 preventing air from being inhaled into the lung portion. The resiliency of the anchor members 111-118 moves them from their collapsed state illustrated in FIG. 19 to their deployed state. The resiliency of obstructingmember 90 may assist anchor members 111-118 in deployment. In the alternative embodiment where the length of anchors 111-118 is limited to allow the anchors 111-118 to penetrate into but not through the air passageway wall, the anchors penetrate theair passageway wall 150 in the manner illustrated in FIG. 7. - FIGS.21-24 are side views showing an embodiment of the present invention for removing the
intra-bronchial device 200 fromair passageway 50. The preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect ofintra-bronchial device 200. The preclusion of air by the embodiment illustrated in FIG. 18 may be eliminated by releasing anchors 111-118 from theair passageway wall 130. - A
bronchoscope 74 is placed in proximity tointra-bronchial device 200 in theair passageway 50. Acatheter 70 having aninternal lumen 71 is fed into thebronchoscope 74 and advanced to the proximal end of theintra-bronchial device 200. A retractor device, such asbiopsy forceps 76, capable of gripping a portion ofintra-bronchial device 200, is inserted in thecatheter 70 of thebronchoscope 74 and advanced to theintra-bronchial device 200. The jaws of theforceps 76 are used to engage a portion of the obstructingmember 90. The engagement may collapse a portion of obstructingmember 90. The engagement with the obstructingmember 90 is maintained and obstructingmember 90 is drawn toward thecatheter lumen 71 by theforceps 76. The drawing action releases anchors 111-118 fromair passageway wall 130. Theintra-bronchial device 200 is then drawn into thecatheter lumen 71 with theforceps 76. Thecollapsed device 200 now fully enters thecatheter lumen 71 for removal from the patient. - FIG. 25 is a perspective view of an intra-bronchial device with anchors projecting from a periphery of an obstructing member as the device would appear when fully deployed, in accordance with an alternative embodiment of the present invention. The
intra-bronchial device 210 includessupport members member 110; “s” shaped bends 212, 214, 216, and 218; and anchors 112, 114, 116, and 118. - The
support members member 110, and includeanchors support members Support members intra-bronchial device 210. They may be joined by a mechanical method, such as by crimping, or by other methods such as adhesive or welding. In an alternative embodiment, two support members may be formed from a single piece of material by bending it in the middle.Support members -
Anchors support members - The obstructing
member 110 is carried on the support structure formed bysupport members member 110 includes a flexible membrane open in the proximal direction and which may be formed of silicone or polyurethane, for example. The obstructingmember 110 includesopenings support members member 110 to supportmember 102 at “s”bend 212. Obstructingmember 110 is fitted over theanchor end 122 andanchor 112 atopening 222. Obstructingmember 110 engages the peripheral apex of the “s” shapedbend 212, and thus secures it. The obstructingmember 110 is placed and secured to the other “s” bends 214, 216, and 218 in a similar manner. Obstructingmember 110 may be loosely carried onsupport members - FIG. 27 is a perspective view of the intra-bronchial device of FIG. 25 fully deployed and anchored in an air passageway, in accordance with the present invention.
Intra-bronchial device 210 is illustrated after having been expelled from the catheter lumen in substantially the manner described in conjunction with FIG. 3, and having deployedanchors air passageway wall 130 ofair passageway 50. The piercing engages the air passageway wall and anchorsintra-bronchial device 210 within theair passageway 50. - Deploying obstructing
member 210 is much like opening an umbrella. Upon deployment, the memory and resiliency of thesupport members member 210. The expanded obstructingmember 210 forms acontact zone 129 with thewall 130 of theair passageway 50 to prevent air from being inhaled into the lung portion to collapse the lung portion. Simultaneously upon deployment, the memory and resiliency of thesupport members anchors air passageway wall 130 by piercing. The anchors pierce into and become embedded in thewall 130 of theair passageway 50, preferably without projecting through thewall 130. Stops may be incorporated into the anchors to limit piercing of thewall 130. For example, the “s” bends 212, 214, 216, and 218 may form a stop. - The preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect of
intra-bronchial device 210. The preclusion of air by the embodiment illustrated in FIGS. 25-27 may be eliminated by releasinganchors air passageway wall 130. The anchors are released and theintra-bronchial device 210 is removed fromair passageway 50 in substantially the same manner described in conjunction with FIGS. 7, and 21-24. The forceps are used to engage a portion ofintra-bronchial device 210, and maneuvered to releaseanchors air passageway wall 130.Intra-bronchial device 210 is then drawn into the catheter for removal from the patient. Alternatively, the obstructing effect may be eliminated by engaging the obstructingmember 210, releasing it from thesupport members member 110 into the catheter for removal from the patent. - Although the present invention has been described in considerable detail with reference to certain preferred embodiments, other embodiments are possible. Therefore, the spirit or scope of the appended claims should not be limited to the description of the embodiments contained herein. It is intended that the invention resides in the claims hereinafter appended.
Claims (22)
1. An intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway, the device comprising:
an obstructing member that prevents air from being inhaled into the lung portion to collapse the lung portion; and
an anchor that anchors the obstruction device within the air passageway when the anchor is deployed.
2. The intra-bronchial device of claim 1 , wherein the anchor engages the air passageway wall.
3. The intra-bronchial device of claim 1 , wherein the anchor pierces into the air passageway wall.
4. The intra-bronchial device of claim 1 , wherein the obstructing member and the anchor are simultaneously deployable.
5. The intra-bronchial device of claim 1 , wherein the anchor is releasable from the air passageway for removal of the obstructing member.
6. The intra-bronchial device of claim 1 wherein a portion of the intra-bronchial device is collapsible.
7. The intra-bronchial device of claim 6 , wherein the anchor is releasable from the air passageway for removal of the obstructing member by collapsing a portion of the obstructing member.
8. The intra-bronchial device of claim 6 , wherein the anchor is releasable from the air passageway for removal of the obstructing member by drawing the obstructing member proximally.
9. The intra-bronchial device of claim 1 , wherein the anchor includes a resilient material for imparting a force against the air passageway to deform the air passageway to more positively anchor the obstructing member.
10. The intra-bronchial device of claim 1 , wherein the obstructing member comprises material having memory of an original shape, and resiliency to return the material to that shape.
11. The intra-bronchial device of claim 1 , wherein the anchor comprises material having memory of an original shape, and resiliency to return the material to that shape.
12. The intra-bronchial device of claim 1 , wherein the obstructing member is a one-way valve.
13. A method of reducing the size of a lung by collapsing a portion of the lung, the method including the steps of:
providing an intra-bronchial device comprising an obstructing member which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and an anchor that anchors the obstructing member when the anchor is deployed;
placing the obstructing member in the air passageway; and
deploying the anchor.
14. The method of claim 13 , wherein the anchor is releasable for removal of the obstructing member.
15. The method of claim 13 , wherein the obstructing member forms a one-way valve.
16. The method of claim 13 , wherein a portion of the obstructing member is collapsible.
17. A method of reducing the size of a lung by collapsing a portion of the lung with a removable device, the method including the steps of:
providing an intra-bronchial device an obstructing member which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and an anchor that anchors the obstructing member when the anchor is deployed;
placing the obstructing member in the air passageway;
deploying an anchor; and
removing the obstructing member.
18. The method of claim 17 , wherein the anchor is releasable from the air passageway for removal of the intra-bronchial device, and the step of removing the obstructing member includes the further step of releasing the anchor.
19. The method of claim 17 , wherein the obstructing member forms a one-way valve.
20. The method of claim 17 , wherein at least a portion of the obstructing member is collapsible, and the step of removing the obstructing member includes the further step of collapsing a portion of the obstructing member.
21. An air passageway obstructing device comprising:
obstructing means for obstructing air flow within the air passageway; and
anchoring means to anchor the air passageway obstructing device within the air passageway.
22. An air passageway obstructing device comprising:
obstructing means for obstructing air flow within the air passageway; and
anchoring means to anchor the air passageway obstructing device within the air passageway, the anchoring means being releasable for removal of the obstructing means from the air passageway.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/103,487 US20030181922A1 (en) | 2002-03-20 | 2002-03-20 | Removable anchored lung volume reduction devices and methods |
JP2003577779A JP4387803B2 (en) | 2002-03-20 | 2003-02-26 | Detachable anchored lung volume reduction device |
EP03716212.0A EP1494632B1 (en) | 2002-03-20 | 2003-02-26 | Removable anchored lung volume reduction devices |
CA002479805A CA2479805A1 (en) | 2002-03-20 | 2003-02-26 | Removable anchored lung volume reduction devices and methods |
PCT/US2003/005968 WO2003079944A1 (en) | 2002-03-20 | 2003-02-26 | Removable anchored lung volume reduction devices and methods |
AU2003219927A AU2003219927A1 (en) | 2002-03-20 | 2003-02-26 | Removable anchored lung volume reduction devices and methods |
EP10196887.3A EP2353557B1 (en) | 2002-03-20 | 2003-02-26 | Removable anchored lung volume reduction devices |
US11/880,090 US8021385B2 (en) | 2002-03-20 | 2007-07-19 | Removable anchored lung volume reduction devices and methods |
US13/198,546 US8177805B2 (en) | 2002-03-20 | 2011-08-04 | Removable anchored lung volume reduction devices and methods |
US13/415,616 US8603127B2 (en) | 2002-03-20 | 2012-03-08 | Removable anchored lung volume reduction devices and methods |
US13/853,345 US8926647B2 (en) | 2002-03-20 | 2013-03-29 | Removable anchored lung volume reduction devices and methods |
US14/581,414 US20150305749A1 (en) | 2002-03-20 | 2014-12-23 | Removable anchored lung volume reduction devices and methods |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/103,487 US20030181922A1 (en) | 2002-03-20 | 2002-03-20 | Removable anchored lung volume reduction devices and methods |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/880,090 Continuation US8021385B2 (en) | 2002-03-20 | 2007-07-19 | Removable anchored lung volume reduction devices and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
US20030181922A1 true US20030181922A1 (en) | 2003-09-25 |
Family
ID=28040404
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/103,487 Abandoned US20030181922A1 (en) | 2002-03-20 | 2002-03-20 | Removable anchored lung volume reduction devices and methods |
US11/880,090 Active 2024-10-12 US8021385B2 (en) | 2002-03-20 | 2007-07-19 | Removable anchored lung volume reduction devices and methods |
US13/198,546 Expired - Lifetime US8177805B2 (en) | 2002-03-20 | 2011-08-04 | Removable anchored lung volume reduction devices and methods |
US13/415,616 Expired - Lifetime US8603127B2 (en) | 2002-03-20 | 2012-03-08 | Removable anchored lung volume reduction devices and methods |
US13/853,345 Expired - Fee Related US8926647B2 (en) | 2002-03-20 | 2013-03-29 | Removable anchored lung volume reduction devices and methods |
US14/581,414 Abandoned US20150305749A1 (en) | 2002-03-20 | 2014-12-23 | Removable anchored lung volume reduction devices and methods |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/880,090 Active 2024-10-12 US8021385B2 (en) | 2002-03-20 | 2007-07-19 | Removable anchored lung volume reduction devices and methods |
US13/198,546 Expired - Lifetime US8177805B2 (en) | 2002-03-20 | 2011-08-04 | Removable anchored lung volume reduction devices and methods |
US13/415,616 Expired - Lifetime US8603127B2 (en) | 2002-03-20 | 2012-03-08 | Removable anchored lung volume reduction devices and methods |
US13/853,345 Expired - Fee Related US8926647B2 (en) | 2002-03-20 | 2013-03-29 | Removable anchored lung volume reduction devices and methods |
US14/581,414 Abandoned US20150305749A1 (en) | 2002-03-20 | 2014-12-23 | Removable anchored lung volume reduction devices and methods |
Country Status (1)
Country | Link |
---|---|
US (6) | US20030181922A1 (en) |
Cited By (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030050648A1 (en) * | 2001-09-11 | 2003-03-13 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US20030212412A1 (en) * | 2002-05-09 | 2003-11-13 | Spiration, Inc. | Intra-bronchial obstructing device that permits mucus transport |
US20040073230A1 (en) * | 1999-01-28 | 2004-04-15 | Ansamed Limited | Catheter with an expandable end portion |
US20040074491A1 (en) * | 2001-03-02 | 2004-04-22 | Michael Hendricksen | Delivery methods and devices for implantable bronchial isolation devices |
US20040089306A1 (en) * | 2002-05-28 | 2004-05-13 | Ronald Hundertmark | Devices and methods for removing bronchial isolation devices implanted in the lung |
WO2005044138A2 (en) | 2003-10-31 | 2005-05-19 | Cordis Corporation | Implantable valvular prothesis |
US20060047291A1 (en) * | 2004-08-20 | 2006-03-02 | Uptake Medical Corporation | Non-foreign occlusion of an airway and lung collapse |
US7011094B2 (en) * | 2001-03-02 | 2006-03-14 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
WO2006055047A2 (en) * | 2004-11-18 | 2006-05-26 | Mark Adler | Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor |
US20060161233A1 (en) * | 2004-11-16 | 2006-07-20 | Uptake Medical Corp. | Device and method for lung treatment |
US20080110457A1 (en) * | 2006-11-13 | 2008-05-15 | Uptake Medical Corp. | Treatment with high temperature vapor |
US20080132826A1 (en) * | 2003-01-18 | 2008-06-05 | Shadduck John H | Medical instruments and techniques for treating pulmonary disorders |
EP1951129A2 (en) * | 2005-10-19 | 2008-08-06 | Pulsar Vascular, Incorporated | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
US20090114226A1 (en) * | 2000-03-04 | 2009-05-07 | Deem Mark E | Methods and devices for use in performing pulmonary procedures |
US20090255537A1 (en) * | 2004-01-27 | 2009-10-15 | Pulmonx | Disease indications for selective endobronchial lung region isolation |
US7670282B2 (en) | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
US7682332B2 (en) | 2003-07-15 | 2010-03-23 | Portaero, Inc. | Methods to accelerate wound healing in thoracic anastomosis applications |
US7686013B2 (en) | 2006-01-17 | 2010-03-30 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve |
US7699867B2 (en) | 2004-04-16 | 2010-04-20 | Cook Incorporated | Removable vena cava filter for reduced trauma in collapsed configuration |
US7717115B2 (en) | 2002-11-27 | 2010-05-18 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
US7753052B2 (en) | 2003-06-05 | 2010-07-13 | Portaero, Inc. | Intra-thoracic collateral ventilation bypass system |
US7766891B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
US7766938B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US7789083B2 (en) | 2003-05-20 | 2010-09-07 | Portaero, Inc. | Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease |
US7798147B2 (en) | 2001-03-02 | 2010-09-21 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US7811274B2 (en) | 2003-05-07 | 2010-10-12 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7814912B2 (en) | 2002-11-27 | 2010-10-19 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
US7824366B2 (en) | 2004-12-10 | 2010-11-02 | Portaero, Inc. | Collateral ventilation device with chest tube/evacuation features and method |
US7854228B2 (en) | 2001-10-11 | 2010-12-21 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
US7896008B2 (en) | 2003-06-03 | 2011-03-01 | Portaero, Inc. | Lung reduction system |
US7909803B2 (en) | 2008-02-19 | 2011-03-22 | Portaero, Inc. | Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease |
US7931641B2 (en) | 2007-05-11 | 2011-04-26 | Portaero, Inc. | Visceral pleura ring connector |
US7942931B2 (en) | 2002-02-21 | 2011-05-17 | Spiration, Inc. | Device and method for intra-bronchial provision of a therapeutic agent |
US7972353B2 (en) | 2004-04-16 | 2011-07-05 | Cook Medical Technologies Llc | Removable vena cava filter with anchoring feature for reduced trauma |
US20110172786A1 (en) * | 2006-10-31 | 2011-07-14 | Rousseau Robert A | Implantable Repair Device |
US7993323B2 (en) | 2006-11-13 | 2011-08-09 | Uptake Medical Corp. | High pressure and high temperature vapor catheters and systems |
US8016823B2 (en) | 2003-01-18 | 2011-09-13 | Tsunami Medtech, Llc | Medical instrument and method of use |
US8021385B2 (en) | 2002-03-20 | 2011-09-20 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US8043322B2 (en) | 2004-04-16 | 2011-10-25 | Cook Medical Technologies Llc | Removable vena cava filter having inwardly positioned anchoring hooks in collapsed configuration |
US8043301B2 (en) | 2007-10-12 | 2011-10-25 | Spiration, Inc. | Valve loader method, system, and apparatus |
US8062315B2 (en) | 2007-05-17 | 2011-11-22 | Portaero, Inc. | Variable parietal/visceral pleural coupling |
US8079368B2 (en) | 2003-04-08 | 2011-12-20 | Spiration, Inc. | Bronchoscopic lung volume reduction method |
US8104474B2 (en) | 2005-08-23 | 2012-01-31 | Portaero, Inc. | Collateral ventilation bypass system with retention features |
US8105349B2 (en) | 2004-04-16 | 2012-01-31 | Cook Medical Technologies Llc | Removable vena cava filter having primary struts for enhanced retrieval and delivery |
US8136230B2 (en) | 2007-10-12 | 2012-03-20 | Spiration, Inc. | Valve loader method, system, and apparatus |
US8142455B2 (en) | 2006-03-13 | 2012-03-27 | Pneumrx, Inc. | Delivery of minimally invasive lung volume reduction devices |
US8147532B2 (en) | 2007-10-22 | 2012-04-03 | Uptake Medical Corp. | Determining patient-specific vapor treatment and delivery parameters |
US8163034B2 (en) | 2007-05-11 | 2012-04-24 | Portaero, Inc. | Methods and devices to create a chemically and/or mechanically localized pleurodesis |
US8167901B2 (en) | 2004-09-27 | 2012-05-01 | Cook Medical Technologies Llc | Removable vena cava filter comprising struts having axial bends |
US8220460B2 (en) | 2004-11-19 | 2012-07-17 | Portaero, Inc. | Evacuation device and method for creating a localized pleurodesis |
US8246648B2 (en) | 2008-11-10 | 2012-08-21 | Cook Medical Technologies Llc | Removable vena cava filter with improved leg |
US8246672B2 (en) | 2007-12-27 | 2012-08-21 | Cook Medical Technologies Llc | Endovascular graft with separately positionable and removable frame units |
US8251067B2 (en) | 2001-03-02 | 2012-08-28 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US8257381B2 (en) | 2002-05-17 | 2012-09-04 | Spiration, Inc. | One-way valve devices for anchored implantation in a lung |
US8322335B2 (en) | 2007-10-22 | 2012-12-04 | Uptake Medical Corp. | Determining patient-specific vapor treatment and delivery parameters |
US8336540B2 (en) | 2008-02-19 | 2012-12-25 | Portaero, Inc. | Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease |
US8347881B2 (en) | 2009-01-08 | 2013-01-08 | Portaero, Inc. | Pneumostoma management device with integrated patency sensor and method |
US8388650B2 (en) | 2008-09-05 | 2013-03-05 | Pulsar Vascular, Inc. | Systems and methods for supporting or occluding a physiological opening or cavity |
US8444636B2 (en) | 2001-12-07 | 2013-05-21 | Tsunami Medtech, Llc | Medical instrument and method of use |
US8454708B2 (en) | 2006-03-31 | 2013-06-04 | Spiration, Inc. | Articulable anchor |
US8475389B2 (en) | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Methods and devices for assessment of pneumostoma function |
US8518053B2 (en) | 2009-02-11 | 2013-08-27 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
US8545530B2 (en) | 2005-10-19 | 2013-10-01 | Pulsar Vascular, Inc. | Implantable aneurysm closure systems and methods |
US8574226B2 (en) | 2000-12-09 | 2013-11-05 | Tsunami Medtech, Llc | Method for treating tissue |
US8579893B2 (en) | 2005-08-03 | 2013-11-12 | Tsunami Medtech, Llc | Medical system and method of use |
US8579892B2 (en) | 2003-10-07 | 2013-11-12 | Tsunami Medtech, Llc | Medical system and method of use |
US8579888B2 (en) | 2008-06-17 | 2013-11-12 | Tsunami Medtech, Llc | Medical probes for the treatment of blood vessels |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US8721734B2 (en) | 2009-05-18 | 2014-05-13 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US8721632B2 (en) | 2008-09-09 | 2014-05-13 | Tsunami Medtech, Llc | Methods for delivering energy into a target tissue of a body |
US8740921B2 (en) | 2006-03-13 | 2014-06-03 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8795241B2 (en) | 2011-05-13 | 2014-08-05 | Spiration, Inc. | Deployment catheter |
US8876791B2 (en) | 2005-02-25 | 2014-11-04 | Pulmonx Corporation | Collateral pathway treatment using agent entrained by aspiration flow current |
US8900223B2 (en) | 2009-11-06 | 2014-12-02 | Tsunami Medtech, Llc | Tissue ablation systems and methods of use |
US8974527B2 (en) | 2003-08-08 | 2015-03-10 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US8986336B2 (en) | 2001-10-25 | 2015-03-24 | Spiration, Inc. | Apparatus and method for deployment of a bronchial obstruction device |
JP2015083139A (en) * | 2005-10-19 | 2015-04-30 | パルサー バスキュラー インコーポレイテッド | Method and system for endovascularly clipping and repairing lumen and tissue defect |
US9119625B2 (en) | 2011-10-05 | 2015-09-01 | Pulsar Vascular, Inc. | Devices, systems and methods for enclosing an anatomical opening |
US9125639B2 (en) | 2004-11-23 | 2015-09-08 | Pneumrx, Inc. | Steerable device for accessing a target site and methods |
US9161801B2 (en) | 2009-12-30 | 2015-10-20 | Tsunami Medtech, Llc | Medical system and method of use |
US20150351776A1 (en) * | 2014-06-10 | 2015-12-10 | Ethicon Endo-Surgery, Inc. | Bronchus Sealants and Methods of Sealing Bronchial Tubes |
CN105188599A (en) * | 2013-02-08 | 2015-12-23 | 玛芬股份有限公司 | Peripheral sealing venous check-valve |
US9259229B2 (en) | 2012-05-10 | 2016-02-16 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening, including coil-tipped aneurysm devices |
US9277924B2 (en) | 2009-09-04 | 2016-03-08 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening |
GB2513273B (en) * | 2012-02-28 | 2016-03-16 | Spiration Inc | Pulmonary nodule access devices and methods of using the same |
US20160089172A1 (en) * | 2014-09-30 | 2016-03-31 | Boston Scientific Scimed, Inc. | Devices and methods for applying suction |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US9433457B2 (en) | 2000-12-09 | 2016-09-06 | Tsunami Medtech, Llc | Medical instruments and techniques for thermally-mediated therapies |
US9561068B2 (en) | 2008-10-06 | 2017-02-07 | Virender K. Sharma | Method and apparatus for tissue ablation |
US9561067B2 (en) | 2008-10-06 | 2017-02-07 | Virender K. Sharma | Method and apparatus for tissue ablation |
US9561066B2 (en) | 2008-10-06 | 2017-02-07 | Virender K. Sharma | Method and apparatus for tissue ablation |
US9700365B2 (en) | 2008-10-06 | 2017-07-11 | Santa Anna Tech Llc | Method and apparatus for the ablation of gastrointestinal tissue |
US9782211B2 (en) | 2013-10-01 | 2017-10-10 | Uptake Medical Technology Inc. | Preferential volume reduction of diseased segments of a heterogeneous lobe |
US9924992B2 (en) | 2008-02-20 | 2018-03-27 | Tsunami Medtech, Llc | Medical system and method of use |
US9943353B2 (en) | 2013-03-15 | 2018-04-17 | Tsunami Medtech, Llc | Medical system and method of use |
US10004510B2 (en) | 2011-06-03 | 2018-06-26 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening, including shock absorbing aneurysm devices |
US10022212B2 (en) | 2011-01-13 | 2018-07-17 | Cook Medical Technologies Llc | Temporary venous filter with anti-coagulant delivery method |
US10064697B2 (en) | 2008-10-06 | 2018-09-04 | Santa Anna Tech Llc | Vapor based ablation system for treating various indications |
US10179019B2 (en) | 2014-05-22 | 2019-01-15 | Aegea Medical Inc. | Integrity testing method and apparatus for delivering vapor to the uterus |
US10238446B2 (en) | 2010-11-09 | 2019-03-26 | Aegea Medical Inc. | Positioning method and apparatus for delivering vapor to the uterus |
USD845467S1 (en) | 2017-09-17 | 2019-04-09 | Uptake Medical Technology Inc. | Hand-piece for medical ablation catheter |
US10299856B2 (en) | 2014-05-22 | 2019-05-28 | Aegea Medical Inc. | Systems and methods for performing endometrial ablation |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US10485604B2 (en) | 2014-12-02 | 2019-11-26 | Uptake Medical Technology Inc. | Vapor treatment of lung nodules and tumors |
US10531906B2 (en) | 2015-02-02 | 2020-01-14 | Uptake Medical Technology Inc. | Medical vapor generator |
US10624647B2 (en) | 2011-06-03 | 2020-04-21 | Pulsar Vascular, Inc. | Aneurysm devices with additional anchoring mechanisms and associated systems and methods |
US10695126B2 (en) | 2008-10-06 | 2020-06-30 | Santa Anna Tech Llc | Catheter with a double balloon structure to generate and apply a heated ablative zone to tissue |
US10758292B2 (en) | 2007-08-23 | 2020-09-01 | Aegea Medical Inc. | Uterine therapy device and method |
US10881442B2 (en) | 2011-10-07 | 2021-01-05 | Aegea Medical Inc. | Integrity testing method and apparatus for delivering vapor to the uterus |
US11129673B2 (en) | 2017-05-05 | 2021-09-28 | Uptake Medical Technology Inc. | Extra-airway vapor ablation for treating airway constriction in patients with asthma and COPD |
US20210346144A1 (en) * | 2015-05-18 | 2021-11-11 | Pulmair Medical, Inc. | Implantable Artificial Bronchus And Use Of An Implantable Artificial Bronchus |
US11284931B2 (en) | 2009-02-03 | 2022-03-29 | Tsunami Medtech, Llc | Medical systems and methods for ablating and absorbing tissue |
US11331140B2 (en) | 2016-05-19 | 2022-05-17 | Aqua Heart, Inc. | Heated vapor ablation systems and methods for treating cardiac conditions |
US11331037B2 (en) | 2016-02-19 | 2022-05-17 | Aegea Medical Inc. | Methods and apparatus for determining the integrity of a bodily cavity |
US11344364B2 (en) | 2017-09-07 | 2022-05-31 | Uptake Medical Technology Inc. | Screening method for a target nerve to ablate for the treatment of inflammatory lung disease |
US11350988B2 (en) | 2017-09-11 | 2022-06-07 | Uptake Medical Technology Inc. | Bronchoscopic multimodality lung tumor treatment |
US11419658B2 (en) | 2017-11-06 | 2022-08-23 | Uptake Medical Technology Inc. | Method for treating emphysema with condensable thermal vapor |
US11490946B2 (en) | 2017-12-13 | 2022-11-08 | Uptake Medical Technology Inc. | Vapor ablation handpiece |
US11653927B2 (en) | 2019-02-18 | 2023-05-23 | Uptake Medical Technology Inc. | Vapor ablation treatment of obstructive lung disease |
US11806066B2 (en) | 2018-06-01 | 2023-11-07 | Santa Anna Tech Llc | Multi-stage vapor-based ablation treatment methods and vapor generation and delivery systems |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9198790B2 (en) * | 2010-10-19 | 2015-12-01 | Apollo Endosurgery, Inc. | Upper stomach gastric implants |
US9744033B2 (en) | 2011-04-01 | 2017-08-29 | W.L. Gore & Associates, Inc. | Elastomeric leaflet for prosthetic heart valves |
US10117765B2 (en) | 2011-06-14 | 2018-11-06 | W.L. Gore Associates, Inc | Apposition fiber for use in endoluminal deployment of expandable implants |
US9554806B2 (en) | 2011-09-16 | 2017-01-31 | W. L. Gore & Associates, Inc. | Occlusive devices |
US9782282B2 (en) | 2011-11-14 | 2017-10-10 | W. L. Gore & Associates, Inc. | External steerable fiber for use in endoluminal deployment of expandable devices |
US9877858B2 (en) | 2011-11-14 | 2018-01-30 | W. L. Gore & Associates, Inc. | External steerable fiber for use in endoluminal deployment of expandable devices |
US9375308B2 (en) | 2012-03-13 | 2016-06-28 | W. L. Gore & Associates, Inc. | External steerable fiber for use in endoluminal deployment of expandable devices |
US10068153B2 (en) * | 2012-08-21 | 2018-09-04 | Cognex Corporation | Trainable handheld optical character recognition systems and methods |
ES2773718T3 (en) | 2012-12-04 | 2020-07-14 | Mallinckrodt Hospital Products Ip Ltd | Cannula to minimize dissolution of the dosage during administration of nitric oxide |
US9795756B2 (en) | 2012-12-04 | 2017-10-24 | Mallinckrodt Hospital Products IP Limited | Cannula for minimizing dilution of dosing during nitric oxide delivery |
JP6423851B2 (en) | 2013-03-13 | 2018-11-14 | アーロン・ヴィ・カプラン | Device for emptying the left atrial appendage |
US11399842B2 (en) | 2013-03-13 | 2022-08-02 | Conformal Medical, Inc. | Devices and methods for excluding the left atrial appendage |
US9345564B2 (en) | 2013-03-15 | 2016-05-24 | Cook Medical Technologies Llc | Removable vena cava filter having primary and secondary struts |
US11911258B2 (en) | 2013-06-26 | 2024-02-27 | W. L. Gore & Associates, Inc. | Space filling devices |
AU2014286991A1 (en) * | 2013-07-11 | 2016-01-28 | Shifamed Holdings, Llc | Devices and methods for lung volume reduction |
US10004512B2 (en) * | 2014-01-29 | 2018-06-26 | Cook Biotech Incorporated | Occlusion device and method of use thereof |
CN107438418B (en) | 2015-03-24 | 2022-04-05 | 捷锐士股份有限公司 | Airway stent |
JP2018515246A (en) | 2015-05-14 | 2018-06-14 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティドW.L. Gore & Associates, Incorporated | Devices and methods for atrial appendage occlusion |
US10307243B2 (en) | 2016-03-29 | 2019-06-04 | Spiration, Inc. | Dual membrane airway valve |
US10441289B2 (en) * | 2016-03-30 | 2019-10-15 | Spiration, Inc. | Airway valve with anchors |
US10470839B2 (en) | 2016-06-02 | 2019-11-12 | Covidien Lp | Assessment of suture or staple line integrity and localization of potential tissue defects along the suture or staple line |
WO2018081466A2 (en) | 2016-10-27 | 2018-05-03 | Conformal Medical, Inc. | Devices and methods for excluding the left atrial appendage |
US11426172B2 (en) * | 2016-10-27 | 2022-08-30 | Conformal Medical, Inc. | Devices and methods for excluding the left atrial appendage |
CN110636802B (en) | 2017-03-23 | 2022-10-04 | 捷锐士股份有限公司 | Airway valve apparatus |
US11173023B2 (en) | 2017-10-16 | 2021-11-16 | W. L. Gore & Associates, Inc. | Medical devices and anchors therefor |
EP3787525A4 (en) * | 2018-05-02 | 2022-06-22 | Conformal Medical, Inc. | Devices and methods for excluding the left atrial appendage |
US20210298762A1 (en) * | 2018-08-03 | 2021-09-30 | The Johns Hopkins University | Reversible lacrimal canalicular occlusion device |
WO2020163507A1 (en) | 2019-02-08 | 2020-08-13 | Conformal Medical, Inc. | Devices and methods for excluding the left atrial appendage |
Citations (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2981254A (en) * | 1957-11-12 | 1961-04-25 | Edwin G Vanderbilt | Apparatus for the gas deflation of an animal's stomach |
US3657744A (en) * | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
US3760808A (en) * | 1969-12-01 | 1973-09-25 | K Bleuer | Tampon applicator assembly |
US3788327A (en) * | 1971-03-30 | 1974-01-29 | H Donowitz | Surgical implant device |
US4014318A (en) * | 1973-08-20 | 1977-03-29 | Dockum James M | Circulatory assist device and system |
US4086665A (en) * | 1976-12-16 | 1978-05-02 | Thermo Electron Corporation | Artificial blood conduit |
US4212463A (en) * | 1978-02-17 | 1980-07-15 | Pratt Enoch B | Humane bleeder arrow |
US4250873A (en) * | 1977-04-26 | 1981-02-17 | Richard Wolf Gmbh | Endoscopes |
US4302854A (en) * | 1980-06-04 | 1981-12-01 | Runge Thomas M | Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist |
US4619246A (en) * | 1984-05-23 | 1986-10-28 | William Cook, Europe A/S | Collapsible filter basket |
US4681110A (en) * | 1985-12-02 | 1987-07-21 | Wiktor Dominik M | Catheter arrangement having a blood vessel liner, and method of using it |
US4710192A (en) * | 1985-12-30 | 1987-12-01 | Liotta Domingo S | Diaphragm and method for occlusion of the descending thoracic aorta |
US4727873A (en) * | 1984-04-17 | 1988-03-01 | Mobin Uddin Kazi | Embolus trap |
US4732152A (en) * | 1984-12-05 | 1988-03-22 | Medinvent S.A. | Device for implantation and a method of implantation in a vessel using such device |
US4759758A (en) * | 1984-12-07 | 1988-07-26 | Shlomo Gabbay | Prosthetic heart valve |
US4795449A (en) * | 1986-08-04 | 1989-01-03 | Hollister Incorporated | Female urinary incontinence device |
US4808183A (en) * | 1980-06-03 | 1989-02-28 | University Of Iowa Research Foundation | Voice button prosthesis and method for installing same |
US4819664A (en) * | 1984-11-15 | 1989-04-11 | Stefano Nazari | Device for selective bronchial intubation and separate lung ventilation, particularly during anesthesia, intensive therapy and reanimation |
US4830003A (en) * | 1988-06-17 | 1989-05-16 | Wolff Rodney G | Compressive stent and delivery system |
US4832680A (en) * | 1986-07-03 | 1989-05-23 | C.R. Bard, Inc. | Apparatus for hypodermically implanting a genitourinary prosthesis |
US4846836A (en) * | 1988-10-03 | 1989-07-11 | Reich Jonathan D | Artificial lower gastrointestinal valve |
US4850999A (en) * | 1980-05-24 | 1989-07-25 | Institute Fur Textil-Und Faserforschung Of Stuttgart | Flexible hollow organ |
US4852568A (en) * | 1987-02-17 | 1989-08-01 | Kensey Nash Corporation | Method and apparatus for sealing an opening in tissue of a living being |
US4877025A (en) * | 1988-10-06 | 1989-10-31 | Hanson Donald W | Tracheostomy tube valve apparatus |
US4934999A (en) * | 1987-07-28 | 1990-06-19 | Paul Bader | Closure for a male urethra |
US4968294A (en) * | 1989-02-09 | 1990-11-06 | Salama Fouad A | Urinary control valve and method of using same |
US5061274A (en) * | 1989-12-04 | 1991-10-29 | Kensey Nash Corporation | Plug device for sealing openings and method of use |
US5116564A (en) * | 1988-10-11 | 1992-05-26 | Josef Jansen | Method of producing a closing member having flexible closing elements, especially a heart valve |
US5116360A (en) * | 1990-12-27 | 1992-05-26 | Corvita Corporation | Mesh composite graft |
US5123919A (en) * | 1991-11-21 | 1992-06-23 | Carbomedics, Inc. | Combined prosthetic aortic heart valve and vascular graft |
US5151105A (en) * | 1991-10-07 | 1992-09-29 | Kwan Gett Clifford | Collapsible vessel sleeve implant |
US5158548A (en) * | 1990-04-25 | 1992-10-27 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5283063A (en) * | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
US5304199A (en) * | 1993-01-04 | 1994-04-19 | Gene E. Myers Enterprises, Inc. | Apparatus for arterial total occlusion plaque separation |
US5306234A (en) * | 1993-03-23 | 1994-04-26 | Johnson W Dudley | Method for closing an atrial appendage |
US5314473A (en) * | 1989-07-20 | 1994-05-24 | Godin Norman J | Prosthesis for preventing gastric reflux into the esophagus |
US5352240A (en) * | 1989-05-31 | 1994-10-04 | Promedica International, Inc. | Human heart valve replacement with porcine pulmonary valve |
US5358518A (en) * | 1991-06-25 | 1994-10-25 | Sante Camilli | Artificial venous valve |
US5366478A (en) * | 1993-07-27 | 1994-11-22 | Ethicon, Inc. | Endoscopic surgical sealing device |
US5382261A (en) * | 1992-09-01 | 1995-01-17 | Expandable Grafts Partnership | Method and apparatus for occluding vessels |
US5392775A (en) * | 1994-03-22 | 1995-02-28 | Adkins, Jr.; Claude N. | Duckbill valve for a tracheostomy tube that permits speech |
US5409019A (en) * | 1992-10-30 | 1995-04-25 | Wilk; Peter J. | Coronary artery by-pass method |
US5411552A (en) * | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
US5411507A (en) * | 1993-01-08 | 1995-05-02 | Richard Wolf Gmbh | Instrument for implanting and extracting stents |
US5413599A (en) * | 1988-09-20 | 1995-05-09 | Nippon Zeon Co., Ltd. | Medical valve apparatus |
US5417226A (en) * | 1994-06-09 | 1995-05-23 | Juma; Saad | Female anti-incontinence device |
US5445626A (en) * | 1991-12-05 | 1995-08-29 | Gigante; Luigi | Valve operated catheter for urinary incontinence and retention |
US5453090A (en) * | 1994-03-01 | 1995-09-26 | Cordis Corporation | Method of stent delivery through an elongate softenable sheath |
US5484444A (en) * | 1992-10-31 | 1996-01-16 | Schneider (Europe) A.G. | Device for the implantation of self-expanding endoprostheses |
US5486154A (en) * | 1993-06-08 | 1996-01-23 | Kelleher; Brian S. | Endoscope |
US5499995A (en) * | 1994-05-25 | 1996-03-19 | Teirstein; Paul S. | Body passageway closure apparatus and method of use |
US5500014A (en) * | 1989-05-31 | 1996-03-19 | Baxter International Inc. | Biological valvular prothesis |
US5507754A (en) * | 1993-08-20 | 1996-04-16 | United States Surgical Corporation | Apparatus and method for applying and adjusting an anchoring device |
US5509900A (en) * | 1992-03-02 | 1996-04-23 | Kirkman; Thomas R. | Apparatus and method for retaining a catheter in a blood vessel in a fixed position |
US5549628A (en) * | 1994-02-10 | 1996-08-27 | Bio-Vascular, Inc. | Soft tissue stapling buttress |
US5562608A (en) * | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
US5603698A (en) * | 1993-04-13 | 1997-02-18 | Boston Scientific Corporation | Prosthesis delivery system |
US5645565A (en) * | 1995-06-13 | 1997-07-08 | Ethicon Endo-Surgery, Inc. | Surgical plug |
US5660175A (en) * | 1995-08-21 | 1997-08-26 | Dayal; Bimal | Endotracheal device |
US5662713A (en) * | 1991-10-09 | 1997-09-02 | Boston Scientific Corporation | Medical stents for body lumens exhibiting peristaltic motion |
US5683451A (en) * | 1994-06-08 | 1997-11-04 | Cardiovascular Concepts, Inc. | Apparatus and methods for deployment release of intraluminal prostheses |
US5690644A (en) * | 1992-12-30 | 1997-11-25 | Schneider (Usa) Inc. | Apparatus for deploying body implantable stent |
US5693089A (en) * | 1995-04-12 | 1997-12-02 | Inoue; Kanji | Method of collapsing an implantable appliance |
US5697968A (en) * | 1995-08-10 | 1997-12-16 | Aeroquip Corporation | Check valve for intraluminal graft |
US5702409A (en) * | 1995-07-21 | 1997-12-30 | W. L. Gore & Associates, Inc. | Device and method for reinforcing surgical staples |
US5725519A (en) * | 1996-09-30 | 1998-03-10 | Medtronic Instent Israel Ltd. | Stent loading device for a balloon catheter |
US5752965A (en) * | 1996-10-21 | 1998-05-19 | Bio-Vascular, Inc. | Apparatus and method for producing a reinforced surgical fastener suture line |
US5800339A (en) * | 1989-02-09 | 1998-09-01 | Opticon Medical Inc. | Urinary control valve |
US5803078A (en) * | 1994-05-06 | 1998-09-08 | Brauner; Mark E. | Methods and apparatus for intrapulmonary therapy and drug administration |
US5810837A (en) * | 1992-12-16 | 1998-09-22 | Schneider (Europe) A.G. | Device for the implantation of a self-expanding endoprosthesis |
US5817101A (en) * | 1997-03-13 | 1998-10-06 | Schneider (Usa) Inc | Fluid actuated stent delivery system |
US5925063A (en) * | 1997-09-26 | 1999-07-20 | Khosravi; Farhad | Coiled sheet valve, filter or occlusive device and methods of use |
US5954636A (en) * | 1997-07-15 | 1999-09-21 | Schwartz; Roy E. | Pediatric endotracheal tube with bronchial blocker and method for selectively blocking respiratory airflow to a pediatric patient's lung |
US6010525A (en) * | 1997-08-01 | 2000-01-04 | Peter M. Bonutti | Method and apparatus for securing a suture |
US6149664A (en) * | 1998-08-27 | 2000-11-21 | Micrus Corporation | Shape memory pusher introducer for vasoocclusive devices |
US6165179A (en) * | 1995-05-23 | 2000-12-26 | Boston Scientific Corporation | Vena cava delivery system |
US6203551B1 (en) * | 1999-10-04 | 2001-03-20 | Advanced Cardiovascular Systems, Inc. | Chamber for applying therapeutic substances to an implant device |
US6238334B1 (en) * | 1997-11-03 | 2001-05-29 | Cardio Technologies, Inc. | Method and apparatus for assisting a heart to pump blood |
US6241758B1 (en) * | 1999-05-28 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system and method of use |
US20010010017A1 (en) * | 1996-12-31 | 2001-07-26 | Brice Letac | Alve prosthesis for implantation in body channels |
US6267775B1 (en) * | 1997-03-21 | 2001-07-31 | Schneider (Usa) Inc. | Self-expanding medical device for centering radioactive treatment sources in body vessels |
US20020052626A1 (en) * | 1997-11-07 | 2002-05-02 | Paul Gilson | Embolic protection system |
US6425916B1 (en) * | 1999-02-10 | 2002-07-30 | Michi E. Garrison | Methods and devices for implanting cardiac valves |
US6471718B1 (en) * | 1998-05-15 | 2002-10-29 | American Medical Systems, Inc. | Method and device for loading a stent |
US20030013935A1 (en) * | 2001-07-10 | 2003-01-16 | Spiration, Inc. | Constriction device viewable under X ray fluoroscopy |
US6527761B1 (en) * | 2000-10-27 | 2003-03-04 | Pulmonx, Inc. | Methods and devices for obstructing and aspirating lung tissue segments |
US6558429B2 (en) * | 1997-12-09 | 2003-05-06 | Reflux Corporation | Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof |
US20030167065A1 (en) * | 2002-03-01 | 2003-09-04 | Arvik Enterprises, Llc | Blood vessel occlusion device |
US6629951B2 (en) * | 1999-08-05 | 2003-10-07 | Broncus Technologies, Inc. | Devices for creating collateral in the lungs |
US20030212412A1 (en) * | 2002-05-09 | 2003-11-13 | Spiration, Inc. | Intra-bronchial obstructing device that permits mucus transport |
US6679264B1 (en) * | 2000-03-04 | 2004-01-20 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US20040039250A1 (en) * | 2002-05-28 | 2004-02-26 | David Tholfsen | Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment |
US20040167636A1 (en) * | 2002-05-17 | 2004-08-26 | Dillard David H. | Methods of achieving lung volume reduction with removable anchored devices |
US20040243140A1 (en) * | 2001-09-11 | 2004-12-02 | Alferness Clifton A. | Collapsible intra-bronchial valve devices |
US6904909B2 (en) * | 2000-03-04 | 2005-06-14 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
Family Cites Families (423)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2115298A (en) | 1937-04-16 | 1938-04-26 | Roderick F Brown | Suction tonsillectome |
US2479805A (en) | 1946-08-15 | 1949-08-23 | Toledo Engineering Company Inc | Method of and apparatus for feeding batch materials |
US2728225A (en) | 1953-03-12 | 1955-12-27 | Herbert E Skibitzke | Thermal flowmeter |
US2832078A (en) * | 1956-10-17 | 1958-04-29 | Battelle Memorial Institute | Heart valve |
US3320972A (en) | 1964-04-16 | 1967-05-23 | Roy F High | Prosthetic tricuspid valve and method of and device for fabricating same |
US3370305A (en) * | 1965-05-28 | 1968-02-27 | Goott Bernard | Heart valve with magnetic hinge means |
US3472230A (en) | 1966-12-19 | 1969-10-14 | Fogarty T J | Umbrella catheter |
US3617060A (en) | 1967-04-10 | 1971-11-02 | Warren Iezzi | Pneumothorox-inducing hunting arrow |
US3445916A (en) | 1967-04-19 | 1969-05-27 | Rudolf R Schulte | Method for making an anatomical check valve |
US3540431A (en) | 1968-04-04 | 1970-11-17 | Kazi Mobin Uddin | Collapsible filter for fluid flowing in closed passageway |
US3671979A (en) | 1969-09-23 | 1972-06-27 | Univ Utah | Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve |
US3683913A (en) | 1970-10-05 | 1972-08-15 | Deknatel Inc | Underwater drainage apparatus with air flow meters |
BE789781A (en) | 1971-09-24 | 1973-02-01 | Sherwood Medical Ind Inc | Suction drainage device |
US3874388A (en) | 1973-02-12 | 1975-04-01 | Ochsner Med Found Alton | Shunt defect closure system |
US3889657A (en) | 1974-02-12 | 1975-06-17 | Gomco Surgical Mfg Co | Uterine aspirating curette |
US3962917A (en) | 1974-07-03 | 1976-06-15 | Minato Medical Science Co., Ltd. | Respirometer having thermosensitive elements on both sides of a hot wire |
USRE31040E (en) | 1975-04-24 | 1982-09-28 | St. Jude Medical, Inc. | Heart valve prosthesis |
US4084268A (en) | 1976-04-22 | 1978-04-18 | Shiley Laboratories, Incorporated | Prosthetic tissue heart valve |
JPS6010740Y2 (en) | 1976-08-12 | 1985-04-11 | アイダエンジニアリング株式会社 | rotary clamper |
US4040428A (en) | 1976-08-30 | 1977-08-09 | The Aro Corporation | Control valves for tracheotomy patient or laryngeal prosthesis |
US4056854A (en) | 1976-09-28 | 1977-11-08 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Aortic heart valve catheter |
DK229077A (en) | 1977-05-25 | 1978-11-26 | Biocoating Aps | HEARTBALL PROSTHET AND PROCEDURE FOR MANUFACTURING IT |
US4205282A (en) | 1978-08-21 | 1980-05-27 | Westinghouse Electric Corp. | Phase shifting circuit element |
US4222126A (en) | 1978-12-14 | 1980-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare | Unitized three leaflet heart valve |
US4267839A (en) | 1979-09-12 | 1981-05-19 | Repromed, Inc. | Surgical instrument for use in reversible sterilization or permanent occlusion procedures |
SU852321A1 (en) | 1979-10-02 | 1981-08-07 | Второй Московский Ордена Ленинагосударственный Медицинский Ин-Ститут Им. H.И.Пирогова | Method of treating acute purulent diseases of lungs and pleura of children |
US4301810A (en) | 1980-02-29 | 1981-11-24 | City Of Hope National Medical Center | Ventilatory muscle training apparatus |
US4393879A (en) | 1980-04-11 | 1983-07-19 | Milex Products, Inc. | Tissue-collecting apparatus |
CA1178866A (en) | 1980-06-06 | 1984-12-04 | Donald P. Elliott | Chest drainage apparatus |
US4483200A (en) | 1981-01-19 | 1984-11-20 | Anima Corporation | Thermal pulse flowmeter |
US4339831A (en) | 1981-03-27 | 1982-07-20 | Medtronic, Inc. | Dynamic annulus heart valve and reconstruction ring |
US4403616A (en) | 1981-06-09 | 1983-09-13 | K-Med, Inc. | Expiratory breathing exercise device |
US4402445A (en) | 1981-10-09 | 1983-09-06 | United States Surgical Corporation | Surgical fastener and means for applying same |
US4533137A (en) | 1982-01-19 | 1985-08-06 | Healthscan Inc. | Pulmonary training method |
JPS58163332U (en) | 1982-04-27 | 1983-10-31 | 株式会社豊田自動織機製作所 | Rear confirmation mirror device for forklift |
US4456016A (en) | 1982-07-01 | 1984-06-26 | Trutek Research, Inc. | Inhalation valve |
US4569674A (en) * | 1982-08-03 | 1986-02-11 | Stryker Corporation | Continuous vacuum wound drainage system |
US4888015A (en) | 1982-08-20 | 1989-12-19 | Domino Rudolph S | Method of replacing an eye lens |
US4654029A (en) * | 1982-12-13 | 1987-03-31 | Howmedica, Inc. | Electronic drainage system |
FR2538705B1 (en) | 1982-12-29 | 1987-12-31 | Vincent Michel | MEDICAL APPARATUS FOR THE EXSUFFLATION OF TIRES |
US4512338A (en) | 1983-01-25 | 1985-04-23 | Balko Alexander B | Process for restoring patency to body vessels |
US5669936A (en) | 1983-12-09 | 1997-09-23 | Endovascular Technologies, Inc. | Endovascular grafting system and method for use therewith |
US4601465A (en) | 1984-03-22 | 1986-07-22 | Roy Jean Yves | Device for stimulating the human respiratory system |
US4583541A (en) | 1984-05-07 | 1986-04-22 | Barry Joseph P | Sternal stabilization device |
US5135531A (en) | 1984-05-14 | 1992-08-04 | Surgical Systems & Instruments, Inc. | Guided atherectomy system |
US4610256A (en) | 1984-09-25 | 1986-09-09 | Utah Medical Products, Inc. | Pressure transducer |
US4685908A (en) | 1984-10-18 | 1987-08-11 | Bioresearch Ithaca Inc. | Device for detecting increased pressure in pleural cavity |
US4684363A (en) | 1984-10-31 | 1987-08-04 | American Hospital Supply Corporation | Rapidly inflatable balloon catheter and method |
US4582058A (en) | 1984-11-26 | 1986-04-15 | Bivona, Inc. | Tracheostoma valves |
US4881939A (en) | 1985-02-19 | 1989-11-21 | The Johns Hopkins University | Implantable helical cuff |
US4654027A (en) * | 1985-10-30 | 1987-03-31 | Dragan William B | Vascular dilating device |
SU1371700A1 (en) | 1986-02-21 | 1988-02-07 | МВТУ им.Н.Э.Баумана | Prosthesis of heart valve |
FR2596978A1 (en) | 1986-04-10 | 1987-10-16 | Peters | BONE FIXING PLATE, PROVIDED WITH SUTURE WIRES |
ES1001021U (en) | 1986-09-02 | 1988-04-16 | Moriones Elosegui Ignacio | Mechanical valvular prothesis for use in cardiac surgery |
US4745925A (en) | 1986-10-06 | 1988-05-24 | Dietz Henry G | Optoelectronic inhalation sensor for monitoring inhalation and for inhalation therapy |
US5300050A (en) | 1986-10-07 | 1994-04-05 | Deknatel Technology Corporation | Drainage device |
JPS63212028A (en) | 1987-02-26 | 1988-09-05 | Matsutani Seisakusho:Kk | String fitting device for eyeless needle |
US4988342A (en) | 1987-03-02 | 1991-01-29 | Atrium Medical Corporation | Improved fluid recovery system |
FR2612597B1 (en) * | 1987-03-20 | 1989-06-23 | Colon Jean | VALVE HAS AT LEAST ONE TILT SHUTTER IN RELATION TO ELASTIC PIVOTS |
US5111823A (en) | 1989-04-20 | 1992-05-12 | National Fertility Institute | Apparatus and method for generating echographic images |
US4794928A (en) | 1987-06-10 | 1989-01-03 | Kletschka Harold D | Angioplasty device and method of using the same |
SU1593651A1 (en) | 1987-07-07 | 1990-09-23 | 1-Й Московский Медицинский Институт Им.И.М.Сеченова | Artery prosthesis |
US4852552A (en) | 1987-09-03 | 1989-08-01 | Pilling Co. | Sternal retractor |
US4936823A (en) * | 1988-05-04 | 1990-06-26 | Triangle Research And Development Corp. | Transendoscopic implant capsule |
US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
US4870975A (en) | 1988-07-05 | 1989-10-03 | Scott Cronk | Suction canister assembly for the collection of body fluids and tissue specimens |
US5556376A (en) | 1988-07-22 | 1996-09-17 | Yoon; Inbae | Multifunctional devices having loop configured portions and collection systems for endoscopic surgical procedures and methods thereof |
US4920978A (en) | 1988-08-31 | 1990-05-01 | Triangle Research And Development Corporation | Method and apparatus for the endoscopic treatment of deep tumors using RF hyperthermia |
GB8822492D0 (en) | 1988-09-24 | 1988-10-26 | Considine J | Apparatus for removing tumours from hollow organs of body |
US4984581A (en) * | 1988-10-12 | 1991-01-15 | Flexmedics Corporation | Flexible guide having two-way shape memory alloy |
EP0372148A1 (en) | 1988-12-09 | 1990-06-13 | Erik Folke Norell | Lung exercising device |
JPH0428596Y2 (en) | 1989-02-07 | 1992-07-10 | ||
US5186711A (en) | 1989-03-07 | 1993-02-16 | Albert Einstein College Of Medicine Of Yeshiva University | Hemostasis apparatus and method |
US5135488A (en) | 1989-03-17 | 1992-08-04 | Merit Medical Systems, Inc. | System and method for monitoring, displaying and recording balloon catheter inflation data |
US4979505A (en) | 1989-06-06 | 1990-12-25 | Cox Everard F | Tracheal tube |
US5019086A (en) | 1989-09-12 | 1991-05-28 | Neward Theodore C | Manipulable vacuum extractor for childbirth and method of using the same |
US4995872A (en) | 1989-10-04 | 1991-02-26 | Ferrara Janice J | Expandable catheter and bridge device |
US5038621A (en) | 1989-11-06 | 1991-08-13 | Bicore Monitoring Systems | Variable area obstruction gas flow meter |
US5033312A (en) | 1989-11-06 | 1991-07-23 | Bicore Monitoring Systems | Gas flow meter housing |
US5797907A (en) | 1989-11-06 | 1998-08-25 | Mectra Labs, Inc. | Electrocautery cutter |
US5174283A (en) | 1989-11-08 | 1992-12-29 | Parker Jeffrey D | Blind orolaryngeal and oroesophageal guiding and aiming device |
US5516336A (en) | 1990-02-07 | 1996-05-14 | Advanced Cardiovascular Systems, Inc. | Readily exchangeable perfusion dilatation catheter |
US5514153A (en) * | 1990-03-02 | 1996-05-07 | General Surgical Innovations, Inc. | Method of dissecting tissue layers |
US5127412A (en) | 1990-03-14 | 1992-07-07 | Cosmetto Aristodeme J | Skin tensioning |
US5593413A (en) | 1990-05-14 | 1997-01-14 | Medisys Technologies, Inc. | Device for assisting childbirth |
DK124690D0 (en) | 1990-05-18 | 1990-05-18 | Henning Rud Andersen | FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION |
US5078739A (en) * | 1990-07-20 | 1992-01-07 | Janus Biomedical, Inc. | Bileaflet heart valve with external leaflets |
RU1767723C (en) * | 1990-08-14 | 1995-01-27 | Кирово-Чепецкий химический комбинат | Artificial heart valve |
US5092781A (en) * | 1990-11-08 | 1992-03-03 | Amp Incorporated | Electrical connector using shape memory alloy coil springs |
EP0513309A1 (en) | 1990-12-11 | 1992-11-19 | JOHNSON & JOHNSON PROFESSIONAL PRODUCTS LIMITED | Hot wire anemometer |
US5059208A (en) | 1991-02-04 | 1991-10-22 | Helix Medical, Inc. | Adjustable tracheostoma valve |
US5224238A (en) | 1991-04-18 | 1993-07-06 | Ryobi Motor Products Corp. | Horizontal canister vacuum |
US5226429A (en) | 1991-06-20 | 1993-07-13 | Inamed Development Co. | Laparoscopic gastric band and method |
US5147369A (en) | 1991-07-01 | 1992-09-15 | Wagner Michael A | Forceps and method for nuclear fragment removal |
US5171299A (en) | 1991-08-02 | 1992-12-15 | Baxter International Inc. | Balloon catheter inflation pressure and diameter display apparatus and method |
US5163944A (en) | 1991-08-09 | 1992-11-17 | Neward Theodore C | Obstetrical vacuum extractor |
US5207702A (en) | 1991-08-14 | 1993-05-04 | Pearl Michael L | Method and apparatus for handling hygroscopic dilators |
US5876445A (en) * | 1991-10-09 | 1999-03-02 | Boston Scientific Corporation | Medical stents for body lumens exhibiting peristaltic motion |
US5197485A (en) | 1991-10-15 | 1993-03-30 | Pilling Co. | Method and apparatus for sampling aortic plaque |
US5741271A (en) | 1991-11-05 | 1998-04-21 | Nakao; Naomi L. | Surgical retrieval assembly and associated method |
US5197963A (en) | 1991-12-02 | 1993-03-30 | Everest Medical Corporation | Electrosurgical instrument with extendable sheath for irrigation and aspiration |
US5391205A (en) * | 1991-12-17 | 1995-02-21 | Knight; Roy F. | Tracheoesophageal voice prosthesis |
US5626605A (en) | 1991-12-30 | 1997-05-06 | Scimed Life Systems, Inc. | Thrombosis filter |
US5275169A (en) * | 1992-01-15 | 1994-01-04 | Innovation Associates | Apparatus and method for determining physiologic characteristics of body lumens |
US5255687A (en) | 1992-01-21 | 1993-10-26 | Mckenna Charles L | Zero dead space respiratory exercise valve |
DE69334196T2 (en) | 1992-01-21 | 2009-01-02 | Regents Of The University Of Minnesota, Minneapolis | Closure device of a septal defect |
US5409444A (en) | 1992-03-04 | 1995-04-25 | Kensey Nash Corporation | Method and apparatus to reduce injury to the vascular system |
US5421325A (en) | 1992-04-30 | 1995-06-06 | Cinberg; James Z. | Endotracheal tube assembly and related method |
US5342298A (en) | 1992-07-31 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Automated fluid pressure control system |
FR2696092B1 (en) | 1992-09-28 | 1994-12-30 | Lefebvre Jean Marie | Kit for medical use composed of a filter and its device for placement in the vessel. |
US5356412A (en) | 1992-10-09 | 1994-10-18 | United States Surgical Corporation | Sternum buckle with rotational engagement and method of closure |
US5643317A (en) | 1992-11-25 | 1997-07-01 | William Cook Europe S.A. | Closure prosthesis for transcatheter placement |
US5366475A (en) | 1992-12-21 | 1994-11-22 | Shatzu Health Products, Inc. | Tragus acupressure clip |
JPH06230457A (en) | 1993-02-01 | 1994-08-19 | Konica Corp | Camera |
JPH0819544B2 (en) | 1993-02-05 | 1996-02-28 | 協和電線株式会社 | Lead steel wire for electronic parts and manufacturing method thereof |
US5797960A (en) | 1993-02-22 | 1998-08-25 | Stevens; John H. | Method and apparatus for thoracoscopic intracardiac procedures |
WO1994026175A1 (en) | 1993-05-06 | 1994-11-24 | Vitaphore Corporation | Embolization device |
IL105828A (en) | 1993-05-28 | 1999-06-20 | Medinol Ltd | Medical stent |
US5423830A (en) | 1993-07-07 | 1995-06-13 | Schneebaum; Cary W. | Polyp retrieval method and associated instrument assembly |
JP2958219B2 (en) | 1993-08-20 | 1999-10-06 | 住友ベークライト株式会社 | Endoscopic ligation kit |
WO1995008945A2 (en) | 1993-09-20 | 1995-04-06 | Boston Scientific Corporation | Multiple biopsy sampling device |
US5383470A (en) * | 1993-09-20 | 1995-01-24 | Steve Novak | Portable spirometer |
US5542594A (en) | 1993-10-06 | 1996-08-06 | United States Surgical Corporation | Surgical stapling apparatus with biocompatible surgical fabric |
US5456689A (en) | 1993-10-13 | 1995-10-10 | Arnold J. Kresch | Method and device for tissue resection |
DE4336899C1 (en) * | 1993-10-28 | 1994-12-01 | Novacor Gmbh | Double-leaf heart valve prosthesis |
US5957672A (en) | 1993-11-10 | 1999-09-28 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Blood pump bearing system |
US5490860A (en) | 1993-12-08 | 1996-02-13 | Sofamor Danek Properties, Inc. | Portable power cutting tool |
US5415658A (en) | 1993-12-14 | 1995-05-16 | Pioneer Laboratories, Inc. | Surgical cable loop connector |
US5415660A (en) | 1994-01-07 | 1995-05-16 | Regents Of The University Of Minnesota | Implantable limb lengthening nail driven by a shape memory alloy |
US5772583A (en) | 1994-01-21 | 1998-06-30 | Wright; John T. M. | Sternal retractor with attachments for mitral & tricuspid valve repair |
US5499625A (en) | 1994-01-27 | 1996-03-19 | The Kendall Company | Esophageal-tracheal double lumen airway |
US5398844A (en) * | 1994-01-31 | 1995-03-21 | Boston Scientific Corporation | Multiple ligating band dispenser |
US5871453A (en) | 1994-02-08 | 1999-02-16 | Boston Scientific Corporation | Moveable sample tube multiple biopsy sampling device |
US5411016A (en) * | 1994-02-22 | 1995-05-02 | Scimed Life Systems, Inc. | Intravascular balloon catheter for use in combination with an angioscope |
US5824041A (en) * | 1994-06-08 | 1998-10-20 | Medtronic, Inc. | Apparatus and methods for placement and repositioning of intraluminal prostheses |
US5642730A (en) | 1994-06-17 | 1997-07-01 | Trudell Medical Limited | Catheter system for delivery of aerosolized medicine for use with pressurized propellant canister |
US6056744A (en) * | 1994-06-24 | 2000-05-02 | Conway Stuart Medical, Inc. | Sphincter treatment apparatus |
US6062575A (en) | 1994-07-27 | 2000-05-16 | Mednext, Inc. | Tool shaft coupler |
US5549626A (en) | 1994-12-23 | 1996-08-27 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Vena caval filter |
US5755770A (en) | 1995-01-31 | 1998-05-26 | Boston Scientific Corporatiion | Endovascular aortic graft |
US5575293A (en) | 1995-02-06 | 1996-11-19 | Promex, Inc. | Apparatus for collecting and staging tissue |
US6083141A (en) | 1995-02-10 | 2000-07-04 | Hougen; Everett D. | Portable respiratory exercise apparatus and method for using the same |
US5647857A (en) | 1995-03-16 | 1997-07-15 | Endotex Interventional Systems, Inc. | Protective intraluminal sheath |
US5662622A (en) | 1995-04-04 | 1997-09-02 | Cordis Corporation | Intravascular catheter |
US5634893A (en) | 1995-04-24 | 1997-06-03 | Haemonetics Corporation | Autotransfusion apparatus |
US5752522A (en) * | 1995-05-04 | 1998-05-19 | Cardiovascular Concepts, Inc. | Lesion diameter measurement catheter and method |
DE29507519U1 (en) | 1995-05-05 | 1995-08-10 | Angiomed Ag | Endosphincter and set for releasable closing of the urethra |
EP0773754B1 (en) | 1995-05-25 | 2004-09-01 | Medtronic, Inc. | Stent assembly |
US6312407B1 (en) | 1995-06-05 | 2001-11-06 | Medtronic Percusurge, Inc. | Occlusion of a vessel |
US5704910A (en) | 1995-06-05 | 1998-01-06 | Nephros Therapeutics, Inc. | Implantable device and use therefor |
US5902312A (en) | 1995-07-03 | 1999-05-11 | Frater; Dirk A. | System for mounting bolster material on tissue staplers |
US5766134A (en) | 1995-07-18 | 1998-06-16 | Atrion Medical Products, Inc. | Autogenous bone specimen collector |
US5810855A (en) | 1995-07-21 | 1998-09-22 | Gore Enterprise Holdings, Inc. | Endoscopic device and method for reinforcing surgical staples |
US5817034A (en) | 1995-09-08 | 1998-10-06 | United States Surgical Corporation | Apparatus and method for removing tissue |
US5702418A (en) | 1995-09-12 | 1997-12-30 | Boston Scientific Corporation | Stent delivery system |
US6146384A (en) | 1995-10-13 | 2000-11-14 | Sdgi Holdings, Inc. | Orthopedic fixation device and method of implantation |
CA2234389A1 (en) | 1995-10-13 | 1997-04-17 | Transvascular, Inc. | A device, system and method for interstitial transvascular intervention |
DE69738869D1 (en) | 1996-01-11 | 2008-09-11 | Symbiosis Corp | FLEXIBLE MICRO-SURGICAL INSTRUMENTS WITH A WRAPPING THAT FEATURES VISUAL AND TOUCHABLE POSITION INDICATORS |
WO1997027959A1 (en) | 1996-01-30 | 1997-08-07 | Medtronic, Inc. | Articles for and methods of making stents |
IL125417A (en) | 1996-02-02 | 2004-03-28 | Transvascular Inc | Apparatus for blocking flow through blood vessels |
US5763979A (en) | 1996-02-29 | 1998-06-09 | The United States Of America As Represented By The Secretary Of The Navy | Actuation system for the control of multiple shape memory alloy elements |
US6258083B1 (en) * | 1996-03-29 | 2001-07-10 | Eclipse Surgical Technologies, Inc. | Viewing surgical scope for minimally invasive procedures |
WO1997042871A1 (en) | 1996-05-10 | 1997-11-20 | Cardiovascular Concepts, Inc. | Lesion diameter measurement catheter and method |
US5980545A (en) | 1996-05-13 | 1999-11-09 | United States Surgical Corporation | Coring device and method |
US6152909A (en) | 1996-05-20 | 2000-11-28 | Percusurge, Inc. | Aspiration system and method |
US6958059B2 (en) | 1996-05-20 | 2005-10-25 | Medtronic Ave, Inc. | Methods and apparatuses for drug delivery to an intravascular occlusion |
US6325777B1 (en) | 1996-05-20 | 2001-12-04 | Medtronic Percusurge, Inc. | Low profile catheter valve and inflation adaptor |
JP3690815B2 (en) * | 1996-05-20 | 2005-08-31 | メドトロニック パークサージ インコーポレイテッド | Small section catheter |
US20050245894A1 (en) | 1996-05-20 | 2005-11-03 | Medtronic Vascular, Inc. | Methods and apparatuses for drug delivery to an intravascular occlusion |
US6050972A (en) | 1996-05-20 | 2000-04-18 | Percusurge, Inc. | Guidewire inflation system |
EP0808614B1 (en) * | 1996-05-23 | 2003-02-26 | Samsung Electronics Co., Ltd. | Flexible self-expandable stent and method for making the same |
SE9602226D0 (en) | 1996-06-05 | 1996-06-05 | Astra Ab | Biocompatible glue |
KR980000327U (en) * | 1996-06-13 | 1998-03-30 | 이정행 | Earring hole molding for earring installation |
US5797920A (en) | 1996-06-14 | 1998-08-25 | Beth Israel Deaconess Medical Center | Catheter apparatus and method using a shape-memory alloy cuff for creating a bypass graft in-vivo |
US5855601A (en) * | 1996-06-21 | 1999-01-05 | The Trustees Of Columbia University In The City Of New York | Artificial heart valve and method and device for implanting the same |
FR2750315B1 (en) | 1996-06-26 | 1998-12-18 | Novatech Inc | INTRALARYNGEAL PROSTHESIS |
WO1998000840A1 (en) | 1996-06-28 | 1998-01-08 | Samsung Electronics Co., Ltd. | Thin film magnetic head tip and manufacturing method therefor |
IT1284108B1 (en) | 1996-07-04 | 1998-05-08 | Carlo Rebuffat | SURGICAL PRESIDIUM FOR THE TREATMENT OF PULMONARY EMPHYSEMA |
US6077295A (en) | 1996-07-15 | 2000-06-20 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system |
US5669933A (en) | 1996-07-17 | 1997-09-23 | Nitinol Medical Technologies, Inc. | Removable embolus blood clot filter |
US20020077564A1 (en) | 1996-07-29 | 2002-06-20 | Farallon Medsystems, Inc. | Thermography catheter |
US6102885A (en) | 1996-08-08 | 2000-08-15 | Bass; Lawrence S. | Device for suction-assisted lipectomy and method of using same |
US5830217A (en) | 1996-08-09 | 1998-11-03 | Thomas J. Fogarty | Soluble fixation device and method for stent delivery catheters |
US5782916A (en) * | 1996-08-13 | 1998-07-21 | Galt Laboratories, Inc. | Device for maintaining urinary continence |
US5810806A (en) | 1996-08-29 | 1998-09-22 | Ethicon Endo-Surgery | Methods and devices for collection of soft tissue |
US5702343A (en) | 1996-10-02 | 1997-12-30 | Acorn Medical, Inc. | Cardiac reinforcement device |
US5895387A (en) | 1996-10-09 | 1999-04-20 | Romulo Guerrero | Method of craniofacial bone distraction |
US5769892A (en) | 1996-10-22 | 1998-06-23 | Mitroflow International Inc. | Surgical stapler sleeve for reinforcing staple lines |
US5893867A (en) | 1996-11-06 | 1999-04-13 | Percusurge, Inc. | Stent positioning apparatus and method |
US6447530B1 (en) | 1996-11-27 | 2002-09-10 | Scimed Life Systems, Inc. | Atraumatic anchoring and disengagement mechanism for permanent implant device |
US6102926A (en) | 1996-12-02 | 2000-08-15 | Angiotrax, Inc. | Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use |
US5779649A (en) | 1996-12-17 | 1998-07-14 | Pabban Development, Inc. | Surgical suction wand with filter |
NL1004827C2 (en) | 1996-12-18 | 1998-06-19 | Surgical Innovations Vof | Device for regulating blood circulation. |
US6077214A (en) | 1998-07-29 | 2000-06-20 | Myocor, Inc. | Stress reduction apparatus and method |
US5810809A (en) | 1997-01-13 | 1998-09-22 | Enhanced Orthopaedic Technologies, Inc. | Arthroscopic shaver incorporating electrocautery |
US5989234A (en) * | 1997-01-14 | 1999-11-23 | Deknatel Technology Corporation | Device and system for draining a body cavity and methods related thereto |
US5782896A (en) | 1997-01-29 | 1998-07-21 | Light Sciences Limited Partnership | Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe |
US5919224A (en) * | 1997-02-12 | 1999-07-06 | Schneider (Usa) Inc | Medical device having a constricted region for occluding fluid flow in a body lumen |
US6508825B1 (en) | 1997-02-28 | 2003-01-21 | Lumend, Inc. | Apparatus for treating vascular occlusions |
WO1998038929A1 (en) | 1997-03-06 | 1998-09-11 | Percusurge, Inc. | Intravascular aspiration system |
US5851232A (en) | 1997-03-15 | 1998-12-22 | Lois; William A. | Venous stent |
US6083255A (en) | 1997-04-07 | 2000-07-04 | Broncus Technologies, Inc. | Bronchial stenter |
US6200333B1 (en) * | 1997-04-07 | 2001-03-13 | Broncus Technologies, Inc. | Bronchial stenter |
US6488673B1 (en) | 1997-04-07 | 2002-12-03 | Broncus Technologies, Inc. | Method of increasing gas exchange of a lung |
US6634363B1 (en) | 1997-04-07 | 2003-10-21 | Broncus Technologies, Inc. | Methods of treating lungs having reversible obstructive pulmonary disease |
US6411852B1 (en) | 1997-04-07 | 2002-06-25 | Broncus Technologies, Inc. | Modification of airways by application of energy |
US6283988B1 (en) | 1997-04-07 | 2001-09-04 | Broncus Technologies, Inc. | Bronchial stenter having expandable electrodes |
US6273907B1 (en) | 1997-04-07 | 2001-08-14 | Broncus Technologies, Inc. | Bronchial stenter |
GB2324729B (en) | 1997-04-30 | 2002-01-02 | Bradford Hospitals Nhs Trust | Lung treatment device |
US5957949A (en) | 1997-05-01 | 1999-09-28 | World Medical Manufacturing Corp. | Percutaneous placement valve stent |
US6245102B1 (en) | 1997-05-07 | 2001-06-12 | Iowa-India Investments Company Ltd. | Stent, stent graft and stent valve |
US5855597A (en) * | 1997-05-07 | 1999-01-05 | Iowa-India Investments Co. Limited | Stent valve and stent graft for percutaneous surgery |
US6162245A (en) | 1997-05-07 | 2000-12-19 | Iowa-India Investments Company Limited | Stent valve and stent graft |
US5976158A (en) | 1997-06-02 | 1999-11-02 | Boston Scientific Corporation | Method of using a textured ligating band |
US6007575A (en) | 1997-06-06 | 1999-12-28 | Samuels; Shaun Laurence Wilkie | Inflatable intraluminal stent and method for affixing same within the human body |
US5957919A (en) | 1997-07-02 | 1999-09-28 | Laufer; Michael D. | Bleb reducer |
IL121316A (en) * | 1997-07-15 | 2001-07-24 | Litana Ltd | Implantable medical device of shape memory alloy |
US6626903B2 (en) | 1997-07-24 | 2003-09-30 | Rex Medical, L.P. | Surgical biopsy device |
US5984965A (en) | 1997-08-28 | 1999-11-16 | Urosurge, Inc. | Anti-reflux reinforced stent |
US5954766A (en) | 1997-09-16 | 1999-09-21 | Zadno-Azizi; Gholam-Reza | Body fluid flow control device |
US6322522B1 (en) | 1997-09-22 | 2001-11-27 | Zimmon Science Corp. | Apparatus for separable external serial collection, storage and processing of biopsy specimens |
US6016800A (en) | 1997-10-24 | 2000-01-25 | Century; Theodore J. | Intrapulmonary aerosolizer |
US5976174A (en) | 1997-12-15 | 1999-11-02 | Ruiz; Carlos E. | Medical hole closure device and methods of use |
US5957978A (en) | 1997-12-22 | 1999-09-28 | Hansa Medical Products, Inc. | Valved fenestrated tracheotomy tube |
FR2773702B1 (en) | 1998-01-16 | 2000-04-07 | Johnson & Johnson Internationa | COMPRESSION DEVICE FOR HEMOSTASIS OF AN ORGAN, SUCH AS LIVER |
US7879022B2 (en) | 1998-02-06 | 2011-02-01 | Medrad, Inc. | Rapid exchange fluid jet thrombectomy device and method |
US5944738A (en) | 1998-02-06 | 1999-08-31 | Aga Medical Corporation | Percutaneous catheter directed constricting occlusion device |
JP4199338B2 (en) * | 1998-10-02 | 2008-12-17 | 富士通マイクロエレクトロニクス株式会社 | Semiconductor device and manufacturing method thereof |
US20010016704A1 (en) | 1998-02-19 | 2001-08-23 | Gholam Reza Zadno-Azizi | Low profile fluid delivery and sealing system for a catheter |
US6544192B2 (en) * | 1998-02-25 | 2003-04-08 | Respironics, Inc. | Patient monitor and method of using same |
US6454727B1 (en) | 1998-03-03 | 2002-09-24 | Senorx, Inc. | Tissue acquisition system and method of use |
EP0941713B1 (en) | 1998-03-04 | 2004-11-03 | Schneider (Europe) GmbH | Device to insert an endoprosthesis into a catheter shaft |
US6995675B2 (en) * | 1998-03-09 | 2006-02-07 | Curkendall Leland D | Method and system for agricultural data collection and management |
US6099551A (en) | 1998-03-12 | 2000-08-08 | Shelhigh, Inc. | Pericardial strip and stapler assembly for dividing and sealing visceral tissues and method of use thereof |
US5925060A (en) | 1998-03-13 | 1999-07-20 | B. Braun Celsa | Covered self-expanding vascular occlusion device |
US6911028B2 (en) | 1998-10-28 | 2005-06-28 | John H. Shadduck | Medical instrument working end and method for endoluminal treatments |
US5972009A (en) | 1998-04-07 | 1999-10-26 | Boston Scientific Corporation | Ligating band with rounded edges and method of use of same |
US6009614A (en) * | 1998-04-21 | 2000-01-04 | Advanced Cardiovascular Systems, Inc. | Stent crimping tool and method of use |
US6141855A (en) | 1998-04-28 | 2000-11-07 | Advanced Cardiovascular Systems, Inc. | Stent crimping tool and method of use |
US6003517A (en) | 1998-04-30 | 1999-12-21 | Ethicon Endo-Surgery, Inc. | Method for using an electrosurgical device on lung tissue |
US5974652A (en) | 1998-05-05 | 1999-11-02 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for uniformly crimping a stent onto a catheter |
US6327505B1 (en) | 1998-05-07 | 2001-12-04 | Medtronic, Inc. | Method and apparatus for rf intraluminal reduction and occlusion |
US6493589B1 (en) | 1998-05-07 | 2002-12-10 | Medtronic, Inc. | Methods and apparatus for treatment of pulmonary conditions |
US6024759A (en) | 1998-05-08 | 2000-02-15 | Walter Lorenz Surgical, Inc. | Method and apparatus for performing pectus excavatum repair |
US6174323B1 (en) | 1998-06-05 | 2001-01-16 | Broncus Technologies, Inc. | Method and assembly for lung volume reduction |
US6599311B1 (en) | 1998-06-05 | 2003-07-29 | Broncus Technologies, Inc. | Method and assembly for lung volume reduction |
US6086543A (en) | 1998-06-24 | 2000-07-11 | Rubicor Medical, Inc. | Fine needle and core biopsy devices and methods |
US6296639B1 (en) | 1999-02-12 | 2001-10-02 | Novacept | Apparatuses and methods for interstitial tissue removal |
AU771367B2 (en) | 1998-08-20 | 2004-03-18 | Cook Medical Technologies Llc | Coated implantable medical device |
US6210338B1 (en) | 1998-08-21 | 2001-04-03 | Aga Medical Corp. | Sizing catheter for measuring cardiovascular structures |
US6241678B1 (en) | 1998-08-21 | 2001-06-05 | Aga Medical Corporation | Sizing catheter for measuring septal defects |
IL125965A (en) | 1998-08-27 | 2003-03-12 | Hendler Shoshan | Apparatus and method for acquisition and retrieval of resected biological specimens |
US6264700B1 (en) | 1998-08-27 | 2001-07-24 | Endonetics, Inc. | Prosthetic gastroesophageal valve |
US6342062B1 (en) | 1998-09-24 | 2002-01-29 | Scimed Life Systems, Inc. | Retrieval devices for vena cava filter |
US6331183B1 (en) | 1998-09-24 | 2001-12-18 | Scimed Life Systems, Inc. | Basket filter |
US6096027A (en) | 1998-09-30 | 2000-08-01 | Impra, Inc., A Subsidiary Of C.R. Bard, Inc. | Bag enclosed stent loading apparatus |
US6270527B1 (en) | 1998-10-16 | 2001-08-07 | Sulzer Carbomedics Inc. | Elastic valve with partially exposed stent |
RU2140211C1 (en) | 1998-10-28 | 1999-10-27 | Российская медицинская академия последипломного образования Министерства здравоохранения Российской Федерации | Method of surgical treatment of patients with pathology of respiratory organs complicated with pulmonary hemorrhages |
US6500165B1 (en) | 1998-10-29 | 2002-12-31 | Steven R. Frank | Active antisepsis device |
US6152144A (en) | 1998-11-06 | 2000-11-28 | Appriva Medical, Inc. | Method and device for left atrial appendage occlusion |
US6020380A (en) * | 1998-11-25 | 2000-02-01 | Tap Holdings Inc. | Method of treating chronic obstructive pulmonary disease |
US6051022A (en) | 1998-12-30 | 2000-04-18 | St. Jude Medical, Inc. | Bileaflet valve having non-parallel pivot axes |
US20030190669A1 (en) | 1998-12-30 | 2003-10-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
JP4230118B2 (en) | 1999-01-26 | 2009-02-25 | エドワーズ ライフサイエンシーズ コーポレイション | Flexible heart valve |
EP1025874B1 (en) | 1999-02-01 | 2003-08-27 | Adeva Medical Gesellschaft für Entwicklung und Vertrieb von Medizinischen Implantat-Artikeln mbH | Tracheostomy valve |
US6090041A (en) | 1999-02-16 | 2000-07-18 | Regents Of The University Of California | vacuum actuated surgical retractor and methods |
FR2789889B1 (en) | 1999-02-18 | 2001-04-27 | Tokendo Sarl | SYSTEM FOR LAYING SEMI-RIGID TUBULAR ENDOPROSTHESES |
US6368338B1 (en) | 1999-03-05 | 2002-04-09 | Board Of Regents, The University Of Texas | Occlusion method and apparatus |
US6090035A (en) | 1999-03-19 | 2000-07-18 | Isostent, Inc. | Stent loading assembly for a self-expanding stent |
US6231589B1 (en) | 1999-03-22 | 2001-05-15 | Microvena Corporation | Body vessel filter |
US6146357A (en) | 1999-05-07 | 2000-11-14 | Embol-X, Inc. | Balloon occlusion diameter and pressure measuring devices and methods of use |
US6206918B1 (en) * | 1999-05-12 | 2001-03-27 | Sulzer Carbomedics Inc. | Heart valve prosthesis having a pivot design for improving flow characteristics |
US6168617B1 (en) * | 1999-06-14 | 2001-01-02 | Scimed Life Systems, Inc. | Stent delivery system |
AU766506B2 (en) | 1999-06-18 | 2003-10-16 | Powerlung Inc | Pulmonary exercise device |
US6146388A (en) | 1999-06-21 | 2000-11-14 | Surgical Concepts, Inc. | Rocking apparatus for manipulating element in the eye |
US6234996B1 (en) | 1999-06-23 | 2001-05-22 | Percusurge, Inc. | Integrated inflation/deflation device and method |
US6997951B2 (en) * | 1999-06-30 | 2006-02-14 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6287290B1 (en) | 1999-07-02 | 2001-09-11 | Pulmonx | Methods, systems, and kits for lung volume reduction |
US6241654B1 (en) | 1999-07-07 | 2001-06-05 | Acorn Cardiovasculr, Inc. | Cardiac reinforcement devices and methods |
SE9902610D0 (en) | 1999-07-07 | 1999-07-07 | Astra Ab | Sealing device at medical container |
US6174331B1 (en) | 1999-07-19 | 2001-01-16 | Sulzer Carbomedics Inc. | Heart valve leaflet with reinforced free margin |
US6712812B2 (en) | 1999-08-05 | 2004-03-30 | Broncus Technologies, Inc. | Devices for creating collateral channels |
US7422584B2 (en) | 2002-07-05 | 2008-09-09 | Broncus Technologies, Inc. | Extrapleural airway device and method |
US6749606B2 (en) | 1999-08-05 | 2004-06-15 | Thomas Keast | Devices for creating collateral channels |
US6709427B1 (en) | 1999-08-05 | 2004-03-23 | Kensey Nash Corporation | Systems and methods for delivering agents into targeted tissue of a living being |
US7175644B2 (en) * | 2001-02-14 | 2007-02-13 | Broncus Technologies, Inc. | Devices and methods for maintaining collateral channels in tissue |
US8257428B2 (en) | 1999-08-09 | 2012-09-04 | Cardiokinetix, Inc. | System for improving cardiac function |
AU6896400A (en) | 1999-08-13 | 2001-03-13 | Percusurge, Inc. | Occlusion of a vessel |
US6610043B1 (en) | 1999-08-23 | 2003-08-26 | Bistech, Inc. | Tissue volume reduction |
US6293951B1 (en) | 1999-08-24 | 2001-09-25 | Spiration, Inc. | Lung reduction device, system, and method |
ATE341278T1 (en) | 1999-08-24 | 2006-10-15 | Spiration Inc | LUNG VOLUME REDUCTION SET |
US6328689B1 (en) | 2000-03-23 | 2001-12-11 | Spiration, Inc., | Lung constriction apparatus and method |
US6416554B1 (en) | 1999-08-24 | 2002-07-09 | Spiration, Inc. | Lung reduction apparatus and method |
AUPQ254199A0 (en) | 1999-08-31 | 1999-09-23 | University Of Western Australia, The | Methods and devices for obtaining samples from hollow viscera |
US6280398B1 (en) | 1999-10-18 | 2001-08-28 | Ethicon Endo-Surgery | Methods and devices for collection of soft tissue |
US6402754B1 (en) | 1999-10-20 | 2002-06-11 | Spiration, Inc. | Apparatus for expanding the thorax |
US6398775B1 (en) | 1999-10-21 | 2002-06-04 | Pulmonx | Apparatus and method for isolated lung access |
US6440164B1 (en) | 1999-10-21 | 2002-08-27 | Scimed Life Systems, Inc. | Implantable prosthetic valve |
US6551303B1 (en) | 1999-10-27 | 2003-04-22 | Atritech, Inc. | Barrier device for ostium of left atrial appendage |
US6689150B1 (en) | 1999-10-27 | 2004-02-10 | Atritech, Inc. | Filter apparatus for ostium of left atrial appendage |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
US6383198B1 (en) | 1999-12-07 | 2002-05-07 | Scimed Life System, Inc. | Flexible vacuum grabber for holding lesions |
US6510846B1 (en) * | 1999-12-23 | 2003-01-28 | O'rourke Sam | Sealed back pressure breathing device |
WO2001045590A2 (en) | 1999-12-23 | 2001-06-28 | Percusurge, Inc. | Strut design for an occlusion device |
US6277083B1 (en) | 1999-12-27 | 2001-08-21 | Neothermia Corporation | Minimally invasive intact recovery of tissue |
US6471979B2 (en) | 1999-12-29 | 2002-10-29 | Estrogen Vascular Technology, Llc | Apparatus and method for delivering compounds to a living organism |
NL1014095C2 (en) | 2000-01-17 | 2001-07-18 | Cornelis Hendrikus Anna Witten | Implant valve for implantation into a blood vessel. |
JP5000826B2 (en) | 2000-01-24 | 2012-08-15 | バイオコンパテイブルズ・ユーケイ・リミテツド | Coated implant |
WO2001054685A1 (en) | 2000-01-31 | 2001-08-02 | Genaera Corporation | Mucin synthesis inhibitors |
PL211860B1 (en) | 2000-01-31 | 2012-07-31 | Cook Biotech Inc | Valve stent system |
US6458076B1 (en) | 2000-02-01 | 2002-10-01 | 5 Star Medical | Multi-lumen medical device |
EP1251803B1 (en) | 2000-02-02 | 2005-06-01 | Robert V. Snyders | Artificial heart valve |
US6399366B1 (en) | 2000-02-07 | 2002-06-04 | Eric Seagren | Method and apparatus for composting organic waste together with its packaging cartons, boxes or crates on site |
US6540767B1 (en) | 2000-02-08 | 2003-04-01 | Scimed Life Systems, Inc. | Recoilable thrombosis filtering device and method |
US6600307B2 (en) | 2000-03-02 | 2003-07-29 | Sarnoff Corporation | Method and apparatus for measuring true transmitted power using a broadband dual directional coupler |
US6770070B1 (en) | 2000-03-17 | 2004-08-03 | Rita Medical Systems, Inc. | Lung treatment apparatus and method |
WO2001074271A1 (en) | 2000-03-31 | 2001-10-11 | Broncus Technologies, Inc. | Lung elastic recoil restoring/compression device |
US6514290B1 (en) * | 2000-03-31 | 2003-02-04 | Broncus Technologies, Inc. | Lung elastic recoil restoring or tissue compressing device and method |
EP1284663A4 (en) | 2000-05-18 | 2007-04-18 | Emphasys Medical Inc | Bronchiopulmonary occlusion devices and lung volume reduction methods |
KR100618684B1 (en) * | 2000-06-01 | 2006-09-06 | 주식회사 하이닉스반도체 | CAPACITOR HAVING TaON DIELECTRIC LAYER IN SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING THE SAME |
AU2001267097A1 (en) | 2000-06-16 | 2001-12-24 | Rajiv Doshi | Methods and devices for improving breathing in patients with pulmonary disease |
US6695878B2 (en) | 2000-06-26 | 2004-02-24 | Rex Medical, L.P. | Vascular device for valve leaflet apposition |
WO2002005884A2 (en) | 2000-07-19 | 2002-01-24 | University Of Florida | Method for treating chronic obstructive pulmonary disorder |
US7862500B2 (en) | 2002-08-01 | 2011-01-04 | Cardiokinetix, Inc. | Multiple partitioning devices for heart treatment |
US6485436B1 (en) | 2000-08-10 | 2002-11-26 | Csaba Truckai | Pressure-assisted biopsy needle apparatus and technique |
US20020147462A1 (en) | 2000-09-11 | 2002-10-10 | Closure Medical Corporation | Bronchial occlusion method and apparatus |
US6945989B1 (en) | 2000-09-18 | 2005-09-20 | Endotex Interventional Systems, Inc. | Apparatus for delivering endoluminal prostheses and methods of making and using them |
JP2004510524A (en) | 2000-10-12 | 2004-04-08 | メドトロニック バスキュラー インコーポレイテッド | Method and apparatus for protecting a proximal end of a medical device |
US6540694B1 (en) | 2000-10-16 | 2003-04-01 | Sanarus Medical, Inc. | Device for biopsy tumors |
US7077851B2 (en) | 2000-10-17 | 2006-07-18 | Aesculap Ag & Co. Kg | Aneurysm clip |
DE60025049T2 (en) | 2000-10-17 | 2006-08-03 | Asthmatx, Inc., Mountain View | MODIFYING AIRWAYS BY EXERCISING ENERGY |
US6585639B1 (en) | 2000-10-27 | 2003-07-01 | Pulmonx | Sheath and method for reconfiguring lung viewing scope |
JP4064243B2 (en) | 2000-11-06 | 2008-03-19 | スルーズ サージカル システムズ、インク | Biological tissue examination device |
US6840952B2 (en) * | 2000-12-07 | 2005-01-11 | Mark B. Saker | Tissue tract sealing device |
US20040093075A1 (en) | 2000-12-15 | 2004-05-13 | Titus Kuehne | Stent with valve and method of use thereof |
US6620095B2 (en) | 2000-12-22 | 2003-09-16 | Syde A. Taheri | Cradle-assisted myocardial repair and treatment |
US6653525B2 (en) | 2001-01-18 | 2003-11-25 | The Brigham And Women's Hospital, Inc. | Prosthetic device for respiratory patients |
US6494884B2 (en) | 2001-02-09 | 2002-12-17 | Concentric Medical, Inc. | Methods and devices for delivering occlusion elements |
US20020112729A1 (en) | 2001-02-21 | 2002-08-22 | Spiration, Inc. | Intra-bronchial obstructing device that controls biological interaction with the patient |
US6666862B2 (en) | 2001-03-01 | 2003-12-23 | Cardiac Pacemakers, Inc. | Radio frequency ablation system and method linking energy delivery with fluid flow |
US7011094B2 (en) * | 2001-03-02 | 2006-03-14 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
US6503272B2 (en) * | 2001-03-21 | 2003-01-07 | Cordis Corporation | Stent-based venous valves |
US6638285B2 (en) | 2001-04-16 | 2003-10-28 | Shlomo Gabbay | Biological tissue strip and system and method to seal tissue |
US6958076B2 (en) | 2001-04-16 | 2005-10-25 | Biomedical Research Associates Inc. | Implantable venous valve |
KR100393548B1 (en) | 2001-06-05 | 2003-08-02 | 주식회사 엠아이텍 | Stent |
US6716239B2 (en) | 2001-07-03 | 2004-04-06 | Scimed Life Systems, Inc. | ePTFE graft with axial elongation properties |
US6491706B1 (en) | 2001-07-10 | 2002-12-10 | Spiration, Inc. | Constriction device including fixation structure |
JP4602602B2 (en) * | 2001-07-19 | 2010-12-22 | オリンパス株式会社 | Medical instruments |
US20030018327A1 (en) * | 2001-07-20 | 2003-01-23 | Csaba Truckai | Systems and techniques for lung volume reduction |
AU2002322712A1 (en) | 2001-07-26 | 2003-02-17 | Van L. Phillips | Socket insert having a bladder system |
US6743259B2 (en) * | 2001-08-03 | 2004-06-01 | Core Medical, Inc. | Lung assist apparatus and methods for use |
US6902540B2 (en) | 2001-08-22 | 2005-06-07 | Gerald Dorros | Apparatus and methods for treating stroke and controlling cerebral flow characteristics |
US6589240B2 (en) | 2001-08-28 | 2003-07-08 | Rex Medical, L.P. | Tissue biopsy apparatus with collapsible cutter |
US20050137611A1 (en) | 2001-09-04 | 2005-06-23 | Broncus Technologies, Inc. | Methods and devices for maintaining surgically created channels in a body organ |
EP1435833B1 (en) * | 2001-09-10 | 2014-05-21 | Pulmonx | Apparatus for endobronchial diagnosis |
US20030055331A1 (en) * | 2001-09-11 | 2003-03-20 | Pulmonx | Methods of endobronchial diagnosis using imaging |
US6632239B2 (en) | 2001-10-02 | 2003-10-14 | Spiration, Inc. | Constriction device including reinforced suture holes |
US6893460B2 (en) | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
CA2458595C (en) | 2001-10-11 | 2007-12-04 | Peter M. Wilson | Bronchial flow control devices and methods of use |
US20030083730A1 (en) | 2001-10-25 | 2003-05-01 | Scimed Life Systems, Inc. | Loading cartridge for self-expanding stent |
US6592594B2 (en) * | 2001-10-25 | 2003-07-15 | Spiration, Inc. | Bronchial obstruction device deployment system and method |
US6682250B2 (en) * | 2001-11-07 | 2004-01-27 | Lockheed Martin Corporation | Position-adjustable fastening apparatus and method |
WO2003041779A1 (en) | 2001-11-14 | 2003-05-22 | Emphasys Medical, Inc. | Active pump bronchial implant and methods of use thereof |
US6668832B2 (en) | 2001-12-28 | 2003-12-30 | The Regents Of The University Of California | Endotracheal tube |
US6695791B2 (en) | 2002-01-04 | 2004-02-24 | Spiration, Inc. | System and method for capturing body tissue samples |
US20060235432A1 (en) | 2002-02-21 | 2006-10-19 | Devore Lauri J | Intra-bronchial obstructing device that controls biological interaction with the patient |
US6929637B2 (en) | 2002-02-21 | 2005-08-16 | Spiration, Inc. | Device and method for intra-bronchial provision of a therapeutic agent |
US20030154988A1 (en) | 2002-02-21 | 2003-08-21 | Spiration, Inc. | Intra-bronchial device that provides a medicant intra-bronchially to the patient |
AU2003220124A1 (en) | 2002-03-08 | 2003-09-22 | Emphasys Medical, Inc. | Methods and devices for inducing collapse in lung regions fed by collateral pathways |
US20030181356A1 (en) | 2002-03-11 | 2003-09-25 | Edward Ingenito | Compositions and methods for treating emphysema |
CA2643221A1 (en) | 2002-03-15 | 2003-09-25 | Nmt Medical, Inc. | Coupling system useful in placement of implants |
EP2353557B1 (en) | 2002-03-20 | 2020-05-27 | Spiration, Inc. | Removable anchored lung volume reduction devices |
US20030181922A1 (en) | 2002-03-20 | 2003-09-25 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US20030181890A1 (en) | 2002-03-22 | 2003-09-25 | Schulze Dale R. | Medical device that removably attaches to a bodily organ |
US20030195385A1 (en) * | 2002-04-16 | 2003-10-16 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
CA2482935A1 (en) | 2002-04-19 | 2003-10-30 | Broncus Technologies, Inc. | Devices for maintaining surgically created openings |
US7207946B2 (en) | 2002-05-09 | 2007-04-24 | Spiration, Inc. | Automated provision of information related to air evacuation from a chest cavity |
US6852108B2 (en) | 2002-05-14 | 2005-02-08 | Spiration, Inc. | Apparatus and method for resecting and removing selected body tissue from a site inside a patient |
US20030225445A1 (en) | 2002-05-14 | 2003-12-04 | Derus Patricia M. | Surgical stent delivery devices and methods |
WO2003099188A1 (en) | 2002-05-23 | 2003-12-04 | Otto Bock Healthcare Lp | Pulsating pressure chamber and method for enhanced blood flow |
US20040010209A1 (en) * | 2002-07-15 | 2004-01-15 | Spiration, Inc. | Device and method for measuring the diameter of an air passageway |
US20040059263A1 (en) * | 2002-09-24 | 2004-03-25 | Spiration, Inc. | Device and method for measuring the diameter of an air passageway |
AU2003256798A1 (en) | 2002-07-26 | 2004-02-16 | Emphasys Medical, Inc. | Bronchial flow control devices with membrane seal |
US7086398B2 (en) | 2002-07-31 | 2006-08-08 | Cordis Corporation | Long term oxygen therapy system |
US6886558B2 (en) | 2002-08-28 | 2005-05-03 | Cordis Corporation | Collateral ventilation bypass trap system |
US6849084B2 (en) * | 2002-12-31 | 2005-02-01 | Intek Technology L.L.C. | Stent delivery system |
US20040210248A1 (en) | 2003-03-12 | 2004-10-21 | Spiration, Inc. | Apparatus, method and assembly for delivery of intra-bronchial devices |
US7637934B2 (en) | 2003-03-31 | 2009-12-29 | Merit Medical Systems, Inc. | Medical appliance optical delivery and deployment apparatus and method |
US7387633B2 (en) | 2003-04-04 | 2008-06-17 | Osteomed L.P. | Cranial flap fixation system and method |
US7100616B2 (en) | 2003-04-08 | 2006-09-05 | Spiration, Inc. | Bronchoscopic lung volume reduction method |
KR100789063B1 (en) | 2003-04-11 | 2007-12-26 | 호야 가부시키가이샤 | Method for etching chromium thin film and method for producing photomask |
US7530995B2 (en) | 2003-04-17 | 2009-05-12 | 3F Therapeutics, Inc. | Device for reduction of pressure effects of cardiac tricuspid valve regurgitation |
DE602004023350D1 (en) * | 2003-04-30 | 2009-11-12 | Medtronic Vascular Inc | Percutaneous inserted provisional valve |
US7252086B2 (en) | 2003-06-03 | 2007-08-07 | Cordis Corporation | Lung reduction system |
US7533671B2 (en) | 2003-08-08 | 2009-05-19 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US20050080434A1 (en) | 2003-10-08 | 2005-04-14 | Cedars-Sinai Medical Center | Laparoscopic retractable dissector and suture and needle passer |
US8057533B2 (en) | 2003-10-29 | 2011-11-15 | Boston Scientific Scimed, Inc. | Apparatus with visual marker for guiding deployment of implantable prosthesis |
US7273469B1 (en) | 2003-12-31 | 2007-09-25 | Advanced Cardiovascular Systems, Inc. | Modified needle catheter for directional orientation delivery |
US7704268B2 (en) | 2004-05-07 | 2010-04-27 | Nmt Medical, Inc. | Closure device with hinges |
US8317859B2 (en) | 2004-06-28 | 2012-11-27 | J.W. Medical Systems Ltd. | Devices and methods for controlling expandable prostheses during deployment |
EP2468349B1 (en) | 2004-09-17 | 2019-03-06 | Codman & Shurtleff, Inc. | Thin film metallic devices for plugging aneurysms or vessels |
US6951571B1 (en) | 2004-09-30 | 2005-10-04 | Rohit Srivastava | Valve implanting device |
EP1656963B1 (en) | 2004-11-10 | 2007-11-21 | Creganna Technologies Limited | Stent delivery catheter assembly |
KR20070108141A (en) | 2004-11-16 | 2007-11-08 | 로버트 엘 베리 | Device and method for lung treatment |
US7771472B2 (en) | 2004-11-19 | 2010-08-10 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
SE531468C2 (en) | 2005-04-21 | 2009-04-14 | Edwards Lifesciences Ag | An apparatus for controlling blood flow |
WO2006124822A1 (en) | 2005-05-13 | 2006-11-23 | Alveolus, Inc. | Delivery device allowing visual inspection of an intravascular site |
US7736320B2 (en) | 2005-05-25 | 2010-06-15 | Sierra Medical Technology, Inc. | Self-condensing pH sensor and catheter apparatus |
US7842010B2 (en) | 2005-12-05 | 2010-11-30 | Medrad, Inc. | Pneumatically-operated thrombectomy catheter deployment system |
US8136526B2 (en) | 2006-03-08 | 2012-03-20 | Pulmonx Corporation | Methods and devices to induce controlled atelectasis and hypoxic pulmonary vasoconstriction |
US20070209204A1 (en) | 2006-03-09 | 2007-09-13 | Chase Daniel J | Hose Assembly Process, Device, and Product-by-Process |
US8157837B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US7691151B2 (en) | 2006-03-31 | 2010-04-06 | Spiration, Inc. | Articulable Anchor |
CN2920188Y (en) | 2006-07-13 | 2007-07-11 | 韩新巍 | Air passage integrated double-branch internal stent special conveyor |
DE102006061344A1 (en) | 2006-12-22 | 2008-06-26 | Robert Bosch Gmbh | Clutch hydraulic circuit |
JP2008194250A (en) | 2007-02-14 | 2008-08-28 | Piolax Medical Device:Kk | Delivery tool of tubular organ treatment instrument |
US20090188508A1 (en) | 2007-09-14 | 2009-07-30 | Smith Jr A James | Disposable medical mouthpiece appliance |
US8043301B2 (en) | 2007-10-12 | 2011-10-25 | Spiration, Inc. | Valve loader method, system, and apparatus |
EP2641572B1 (en) | 2007-10-12 | 2019-07-24 | Spiration Inc. | Valve loader method, system, and apparatus |
EP2268189A1 (en) | 2008-05-01 | 2011-01-05 | Spiration, Inc. | Direct lung sensor systems, methods, and apparatuses |
CN102202582B (en) | 2008-09-04 | 2014-07-30 | 库拉希尔公司 | Inflatable device for enteric fistula treatment |
EP2341871B1 (en) | 2008-10-01 | 2017-03-22 | Edwards Lifesciences CardiAQ LLC | Delivery system for vascular implant |
CN102970945A (en) | 2011-05-13 | 2013-03-13 | 斯波瑞申有限公司 | Deployment catheter |
-
2002
- 2002-03-20 US US10/103,487 patent/US20030181922A1/en not_active Abandoned
-
2007
- 2007-07-19 US US11/880,090 patent/US8021385B2/en active Active
-
2011
- 2011-08-04 US US13/198,546 patent/US8177805B2/en not_active Expired - Lifetime
-
2012
- 2012-03-08 US US13/415,616 patent/US8603127B2/en not_active Expired - Lifetime
-
2013
- 2013-03-29 US US13/853,345 patent/US8926647B2/en not_active Expired - Fee Related
-
2014
- 2014-12-23 US US14/581,414 patent/US20150305749A1/en not_active Abandoned
Patent Citations (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2981254A (en) * | 1957-11-12 | 1961-04-25 | Edwin G Vanderbilt | Apparatus for the gas deflation of an animal's stomach |
US3760808A (en) * | 1969-12-01 | 1973-09-25 | K Bleuer | Tampon applicator assembly |
US3657744A (en) * | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
US3788327A (en) * | 1971-03-30 | 1974-01-29 | H Donowitz | Surgical implant device |
US4014318A (en) * | 1973-08-20 | 1977-03-29 | Dockum James M | Circulatory assist device and system |
US4086665A (en) * | 1976-12-16 | 1978-05-02 | Thermo Electron Corporation | Artificial blood conduit |
US4250873A (en) * | 1977-04-26 | 1981-02-17 | Richard Wolf Gmbh | Endoscopes |
US4212463A (en) * | 1978-02-17 | 1980-07-15 | Pratt Enoch B | Humane bleeder arrow |
US4850999A (en) * | 1980-05-24 | 1989-07-25 | Institute Fur Textil-Und Faserforschung Of Stuttgart | Flexible hollow organ |
US4808183A (en) * | 1980-06-03 | 1989-02-28 | University Of Iowa Research Foundation | Voice button prosthesis and method for installing same |
US4302854A (en) * | 1980-06-04 | 1981-12-01 | Runge Thomas M | Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist |
US4727873A (en) * | 1984-04-17 | 1988-03-01 | Mobin Uddin Kazi | Embolus trap |
US4619246A (en) * | 1984-05-23 | 1986-10-28 | William Cook, Europe A/S | Collapsible filter basket |
US4819664A (en) * | 1984-11-15 | 1989-04-11 | Stefano Nazari | Device for selective bronchial intubation and separate lung ventilation, particularly during anesthesia, intensive therapy and reanimation |
US4732152A (en) * | 1984-12-05 | 1988-03-22 | Medinvent S.A. | Device for implantation and a method of implantation in a vessel using such device |
US4759758A (en) * | 1984-12-07 | 1988-07-26 | Shlomo Gabbay | Prosthetic heart valve |
US4681110A (en) * | 1985-12-02 | 1987-07-21 | Wiktor Dominik M | Catheter arrangement having a blood vessel liner, and method of using it |
US4710192A (en) * | 1985-12-30 | 1987-12-01 | Liotta Domingo S | Diaphragm and method for occlusion of the descending thoracic aorta |
US4832680A (en) * | 1986-07-03 | 1989-05-23 | C.R. Bard, Inc. | Apparatus for hypodermically implanting a genitourinary prosthesis |
US4795449A (en) * | 1986-08-04 | 1989-01-03 | Hollister Incorporated | Female urinary incontinence device |
US4852568A (en) * | 1987-02-17 | 1989-08-01 | Kensey Nash Corporation | Method and apparatus for sealing an opening in tissue of a living being |
US4934999A (en) * | 1987-07-28 | 1990-06-19 | Paul Bader | Closure for a male urethra |
US4830003A (en) * | 1988-06-17 | 1989-05-16 | Wolff Rodney G | Compressive stent and delivery system |
US5413599A (en) * | 1988-09-20 | 1995-05-09 | Nippon Zeon Co., Ltd. | Medical valve apparatus |
US4846836A (en) * | 1988-10-03 | 1989-07-11 | Reich Jonathan D | Artificial lower gastrointestinal valve |
US4877025A (en) * | 1988-10-06 | 1989-10-31 | Hanson Donald W | Tracheostomy tube valve apparatus |
US5116564A (en) * | 1988-10-11 | 1992-05-26 | Josef Jansen | Method of producing a closing member having flexible closing elements, especially a heart valve |
US4968294A (en) * | 1989-02-09 | 1990-11-06 | Salama Fouad A | Urinary control valve and method of using same |
US5800339A (en) * | 1989-02-09 | 1998-09-01 | Opticon Medical Inc. | Urinary control valve |
US5352240A (en) * | 1989-05-31 | 1994-10-04 | Promedica International, Inc. | Human heart valve replacement with porcine pulmonary valve |
US5500014A (en) * | 1989-05-31 | 1996-03-19 | Baxter International Inc. | Biological valvular prothesis |
US5314473A (en) * | 1989-07-20 | 1994-05-24 | Godin Norman J | Prosthesis for preventing gastric reflux into the esophagus |
US5562608A (en) * | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
US5061274A (en) * | 1989-12-04 | 1991-10-29 | Kensey Nash Corporation | Plug device for sealing openings and method of use |
US5158548A (en) * | 1990-04-25 | 1992-10-27 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
US5411552A (en) * | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
US5116360A (en) * | 1990-12-27 | 1992-05-26 | Corvita Corporation | Mesh composite graft |
US5358518A (en) * | 1991-06-25 | 1994-10-25 | Sante Camilli | Artificial venous valve |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5151105A (en) * | 1991-10-07 | 1992-09-29 | Kwan Gett Clifford | Collapsible vessel sleeve implant |
US5662713A (en) * | 1991-10-09 | 1997-09-02 | Boston Scientific Corporation | Medical stents for body lumens exhibiting peristaltic motion |
US5123919A (en) * | 1991-11-21 | 1992-06-23 | Carbomedics, Inc. | Combined prosthetic aortic heart valve and vascular graft |
US5445626A (en) * | 1991-12-05 | 1995-08-29 | Gigante; Luigi | Valve operated catheter for urinary incontinence and retention |
US5283063A (en) * | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
US5509900A (en) * | 1992-03-02 | 1996-04-23 | Kirkman; Thomas R. | Apparatus and method for retaining a catheter in a blood vessel in a fixed position |
US5382261A (en) * | 1992-09-01 | 1995-01-17 | Expandable Grafts Partnership | Method and apparatus for occluding vessels |
US5409019A (en) * | 1992-10-30 | 1995-04-25 | Wilk; Peter J. | Coronary artery by-pass method |
US5484444A (en) * | 1992-10-31 | 1996-01-16 | Schneider (Europe) A.G. | Device for the implantation of self-expanding endoprostheses |
US5810837A (en) * | 1992-12-16 | 1998-09-22 | Schneider (Europe) A.G. | Device for the implantation of a self-expanding endoprosthesis |
US5690644A (en) * | 1992-12-30 | 1997-11-25 | Schneider (Usa) Inc. | Apparatus for deploying body implantable stent |
US5304199A (en) * | 1993-01-04 | 1994-04-19 | Gene E. Myers Enterprises, Inc. | Apparatus for arterial total occlusion plaque separation |
US5411507A (en) * | 1993-01-08 | 1995-05-02 | Richard Wolf Gmbh | Instrument for implanting and extracting stents |
US5306234A (en) * | 1993-03-23 | 1994-04-26 | Johnson W Dudley | Method for closing an atrial appendage |
US5603698A (en) * | 1993-04-13 | 1997-02-18 | Boston Scientific Corporation | Prosthesis delivery system |
US5486154A (en) * | 1993-06-08 | 1996-01-23 | Kelleher; Brian S. | Endoscope |
US5366478A (en) * | 1993-07-27 | 1994-11-22 | Ethicon, Inc. | Endoscopic surgical sealing device |
US5507754A (en) * | 1993-08-20 | 1996-04-16 | United States Surgical Corporation | Apparatus and method for applying and adjusting an anchoring device |
US5549628A (en) * | 1994-02-10 | 1996-08-27 | Bio-Vascular, Inc. | Soft tissue stapling buttress |
US5453090A (en) * | 1994-03-01 | 1995-09-26 | Cordis Corporation | Method of stent delivery through an elongate softenable sheath |
US5392775A (en) * | 1994-03-22 | 1995-02-28 | Adkins, Jr.; Claude N. | Duckbill valve for a tracheostomy tube that permits speech |
US5803078A (en) * | 1994-05-06 | 1998-09-08 | Brauner; Mark E. | Methods and apparatus for intrapulmonary therapy and drug administration |
US5499995C1 (en) * | 1994-05-25 | 2002-03-12 | Paul S Teirstein | Body passageway closure apparatus and method of use |
US5499995A (en) * | 1994-05-25 | 1996-03-19 | Teirstein; Paul S. | Body passageway closure apparatus and method of use |
US5683451A (en) * | 1994-06-08 | 1997-11-04 | Cardiovascular Concepts, Inc. | Apparatus and methods for deployment release of intraluminal prostheses |
US5417226A (en) * | 1994-06-09 | 1995-05-23 | Juma; Saad | Female anti-incontinence device |
US5693089A (en) * | 1995-04-12 | 1997-12-02 | Inoue; Kanji | Method of collapsing an implantable appliance |
US6165179A (en) * | 1995-05-23 | 2000-12-26 | Boston Scientific Corporation | Vena cava delivery system |
US5645565A (en) * | 1995-06-13 | 1997-07-08 | Ethicon Endo-Surgery, Inc. | Surgical plug |
US5702409A (en) * | 1995-07-21 | 1997-12-30 | W. L. Gore & Associates, Inc. | Device and method for reinforcing surgical staples |
US5697968A (en) * | 1995-08-10 | 1997-12-16 | Aeroquip Corporation | Check valve for intraluminal graft |
US5660175A (en) * | 1995-08-21 | 1997-08-26 | Dayal; Bimal | Endotracheal device |
US5725519A (en) * | 1996-09-30 | 1998-03-10 | Medtronic Instent Israel Ltd. | Stent loading device for a balloon catheter |
US5752965A (en) * | 1996-10-21 | 1998-05-19 | Bio-Vascular, Inc. | Apparatus and method for producing a reinforced surgical fastener suture line |
US20010010017A1 (en) * | 1996-12-31 | 2001-07-26 | Brice Letac | Alve prosthesis for implantation in body channels |
US5817101A (en) * | 1997-03-13 | 1998-10-06 | Schneider (Usa) Inc | Fluid actuated stent delivery system |
US6267775B1 (en) * | 1997-03-21 | 2001-07-31 | Schneider (Usa) Inc. | Self-expanding medical device for centering radioactive treatment sources in body vessels |
US5954636A (en) * | 1997-07-15 | 1999-09-21 | Schwartz; Roy E. | Pediatric endotracheal tube with bronchial blocker and method for selectively blocking respiratory airflow to a pediatric patient's lung |
US6010525A (en) * | 1997-08-01 | 2000-01-04 | Peter M. Bonutti | Method and apparatus for securing a suture |
US5925063A (en) * | 1997-09-26 | 1999-07-20 | Khosravi; Farhad | Coiled sheet valve, filter or occlusive device and methods of use |
US6238334B1 (en) * | 1997-11-03 | 2001-05-29 | Cardio Technologies, Inc. | Method and apparatus for assisting a heart to pump blood |
US20020052626A1 (en) * | 1997-11-07 | 2002-05-02 | Paul Gilson | Embolic protection system |
US6558429B2 (en) * | 1997-12-09 | 2003-05-06 | Reflux Corporation | Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof |
US6471718B1 (en) * | 1998-05-15 | 2002-10-29 | American Medical Systems, Inc. | Method and device for loading a stent |
US6149664A (en) * | 1998-08-27 | 2000-11-21 | Micrus Corporation | Shape memory pusher introducer for vasoocclusive devices |
US6425916B1 (en) * | 1999-02-10 | 2002-07-30 | Michi E. Garrison | Methods and devices for implanting cardiac valves |
US6241758B1 (en) * | 1999-05-28 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system and method of use |
US6629951B2 (en) * | 1999-08-05 | 2003-10-07 | Broncus Technologies, Inc. | Devices for creating collateral in the lungs |
US6203551B1 (en) * | 1999-10-04 | 2001-03-20 | Advanced Cardiovascular Systems, Inc. | Chamber for applying therapeutic substances to an implant device |
US6679264B1 (en) * | 2000-03-04 | 2004-01-20 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US6904909B2 (en) * | 2000-03-04 | 2005-06-14 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US6694979B2 (en) * | 2000-03-04 | 2004-02-24 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US6527761B1 (en) * | 2000-10-27 | 2003-03-04 | Pulmonx, Inc. | Methods and devices for obstructing and aspirating lung tissue segments |
US20030013935A1 (en) * | 2001-07-10 | 2003-01-16 | Spiration, Inc. | Constriction device viewable under X ray fluoroscopy |
US20040243140A1 (en) * | 2001-09-11 | 2004-12-02 | Alferness Clifton A. | Collapsible intra-bronchial valve devices |
US20050033310A1 (en) * | 2001-09-11 | 2005-02-10 | Alferness Clifton A. | Intra-bronchial valve devices |
US20030167065A1 (en) * | 2002-03-01 | 2003-09-04 | Arvik Enterprises, Llc | Blood vessel occlusion device |
US20030212412A1 (en) * | 2002-05-09 | 2003-11-13 | Spiration, Inc. | Intra-bronchial obstructing device that permits mucus transport |
US20040167636A1 (en) * | 2002-05-17 | 2004-08-26 | Dillard David H. | Methods of achieving lung volume reduction with removable anchored devices |
US20050033344A1 (en) * | 2002-05-17 | 2005-02-10 | Dillard David H. | One-way valve devices for anchored implantation in a lung |
US20040039250A1 (en) * | 2002-05-28 | 2004-02-26 | David Tholfsen | Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment |
Cited By (239)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9204889B2 (en) | 1998-03-27 | 2015-12-08 | Tsunami Medtech, Llc | Medical instrument and method of use |
US8187269B2 (en) | 1998-03-27 | 2012-05-29 | Tsunami Medtech, Llc | Medical instruments and techniques for treating pulmonary disorders |
US8858549B2 (en) | 1998-03-27 | 2014-10-14 | Tsunami Medtech, Llc | Medical instruments and techniques for treating pulmonary disorders |
US7094243B2 (en) * | 1999-01-28 | 2006-08-22 | Salviac Limited | Catheter with an expandable end portion |
US7837692B2 (en) | 1999-01-28 | 2010-11-23 | Salviac Limited | Catheter with an expandable end portion |
US20040073230A1 (en) * | 1999-01-28 | 2004-04-15 | Ansamed Limited | Catheter with an expandable end portion |
US20060264972A1 (en) * | 1999-01-28 | 2006-11-23 | Salviac Limited | Catheter with an expandable end portion |
US8357139B2 (en) * | 2000-03-04 | 2013-01-22 | Pulmonx Corporation | Methods and devices for use in performing pulmonary procedures |
US20090114226A1 (en) * | 2000-03-04 | 2009-05-07 | Deem Mark E | Methods and devices for use in performing pulmonary procedures |
US10675079B2 (en) | 2000-12-09 | 2020-06-09 | Tsunami Medtech, Llc | Method for treating tissue |
US9433457B2 (en) | 2000-12-09 | 2016-09-06 | Tsunami Medtech, Llc | Medical instruments and techniques for thermally-mediated therapies |
US8758341B2 (en) | 2000-12-09 | 2014-06-24 | Tsunami Medtech, Llc | Thermotherapy device |
US10524847B2 (en) | 2000-12-09 | 2020-01-07 | Tsunami Medtech, Llc | Medical instruments and techniques for thermally-mediated therapies |
US8574226B2 (en) | 2000-12-09 | 2013-11-05 | Tsunami Medtech, Llc | Method for treating tissue |
US9615875B2 (en) | 2000-12-09 | 2017-04-11 | Tsunami Med Tech, LLC | Medical instruments and techniques for thermally-mediated therapies |
US8251067B2 (en) | 2001-03-02 | 2012-08-28 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US7011094B2 (en) * | 2001-03-02 | 2006-03-14 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
US7798147B2 (en) | 2001-03-02 | 2010-09-21 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US20040074491A1 (en) * | 2001-03-02 | 2004-04-22 | Michael Hendricksen | Delivery methods and devices for implantable bronchial isolation devices |
US8414655B2 (en) | 2001-09-11 | 2013-04-09 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US20030050648A1 (en) * | 2001-09-11 | 2003-03-13 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US8974484B2 (en) | 2001-09-11 | 2015-03-10 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US7757692B2 (en) | 2001-09-11 | 2010-07-20 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US7854228B2 (en) | 2001-10-11 | 2010-12-21 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
US8986336B2 (en) | 2001-10-25 | 2015-03-24 | Spiration, Inc. | Apparatus and method for deployment of a bronchial obstruction device |
US9468487B2 (en) | 2001-12-07 | 2016-10-18 | Tsunami Medtech, Llc | Medical instrument and method of use |
US8444636B2 (en) | 2001-12-07 | 2013-05-21 | Tsunami Medtech, Llc | Medical instrument and method of use |
US7942931B2 (en) | 2002-02-21 | 2011-05-17 | Spiration, Inc. | Device and method for intra-bronchial provision of a therapeutic agent |
US8926647B2 (en) | 2002-03-20 | 2015-01-06 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US8177805B2 (en) | 2002-03-20 | 2012-05-15 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US8021385B2 (en) | 2002-03-20 | 2011-09-20 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US20030212412A1 (en) * | 2002-05-09 | 2003-11-13 | Spiration, Inc. | Intra-bronchial obstructing device that permits mucus transport |
US8956319B2 (en) * | 2002-05-17 | 2015-02-17 | Spiration, Inc. | One-way valve devices for anchored implantation in a lung |
US8257381B2 (en) | 2002-05-17 | 2012-09-04 | Spiration, Inc. | One-way valve devices for anchored implantation in a lung |
US20120289989A1 (en) * | 2002-05-17 | 2012-11-15 | Spiration, Inc. | One-way valve devices for anchored implantation in a lung |
US20040089306A1 (en) * | 2002-05-28 | 2004-05-13 | Ronald Hundertmark | Devices and methods for removing bronchial isolation devices implanted in the lung |
US7717115B2 (en) | 2002-11-27 | 2010-05-18 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
US7814912B2 (en) | 2002-11-27 | 2010-10-19 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
US20080132826A1 (en) * | 2003-01-18 | 2008-06-05 | Shadduck John H | Medical instruments and techniques for treating pulmonary disorders |
US9113944B2 (en) | 2003-01-18 | 2015-08-25 | Tsunami Medtech, Llc | Method for performing lung volume reduction |
US8016823B2 (en) | 2003-01-18 | 2011-09-13 | Tsunami Medtech, Llc | Medical instrument and method of use |
US8313485B2 (en) | 2003-01-18 | 2012-11-20 | Tsunami Medtech, Llc | Method for performing lung volume reduction |
US7892229B2 (en) | 2003-01-18 | 2011-02-22 | Tsunami Medtech, Llc | Medical instruments and techniques for treating pulmonary disorders |
US8079368B2 (en) | 2003-04-08 | 2011-12-20 | Spiration, Inc. | Bronchoscopic lung volume reduction method |
US7811274B2 (en) | 2003-05-07 | 2010-10-12 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7828789B2 (en) | 2003-05-07 | 2010-11-09 | Portaero, Inc. | Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis |
US8029492B2 (en) | 2003-05-07 | 2011-10-04 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7789083B2 (en) | 2003-05-20 | 2010-09-07 | Portaero, Inc. | Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease |
US7896008B2 (en) | 2003-06-03 | 2011-03-01 | Portaero, Inc. | Lung reduction system |
US7753052B2 (en) | 2003-06-05 | 2010-07-13 | Portaero, Inc. | Intra-thoracic collateral ventilation bypass system |
US8323230B2 (en) | 2003-07-15 | 2012-12-04 | Portaero, Inc. | Methods and devices to accelerate wound healing in thoracic anastomosis applications |
US7682332B2 (en) | 2003-07-15 | 2010-03-23 | Portaero, Inc. | Methods to accelerate wound healing in thoracic anastomosis applications |
US9622752B2 (en) | 2003-08-08 | 2017-04-18 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US8974527B2 (en) | 2003-08-08 | 2015-03-10 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US8579892B2 (en) | 2003-10-07 | 2013-11-12 | Tsunami Medtech, Llc | Medical system and method of use |
US9907599B2 (en) | 2003-10-07 | 2018-03-06 | Tsunami Medtech, Llc | Medical system and method of use |
JP2007509700A (en) * | 2003-10-31 | 2007-04-19 | コーディス・コーポレイション | Implantable valve prosthesis |
EP1684667A4 (en) * | 2003-10-31 | 2007-05-09 | Cordis Corp | Implantable valvular prothesis |
EP1684667A2 (en) * | 2003-10-31 | 2006-08-02 | Cordis Corporation | Implantable valvular prothesis |
WO2005044138A2 (en) | 2003-10-31 | 2005-05-19 | Cordis Corporation | Implantable valvular prothesis |
US20090255537A1 (en) * | 2004-01-27 | 2009-10-15 | Pulmonx | Disease indications for selective endobronchial lung region isolation |
US7972353B2 (en) | 2004-04-16 | 2011-07-05 | Cook Medical Technologies Llc | Removable vena cava filter with anchoring feature for reduced trauma |
US7699867B2 (en) | 2004-04-16 | 2010-04-20 | Cook Incorporated | Removable vena cava filter for reduced trauma in collapsed configuration |
US8043322B2 (en) | 2004-04-16 | 2011-10-25 | Cook Medical Technologies Llc | Removable vena cava filter having inwardly positioned anchoring hooks in collapsed configuration |
US8105349B2 (en) | 2004-04-16 | 2012-01-31 | Cook Medical Technologies Llc | Removable vena cava filter having primary struts for enhanced retrieval and delivery |
US8246651B2 (en) | 2004-04-16 | 2012-08-21 | Cook Medical Technologies Llc | Removable vena cava filter for reduced trauma in collapsed configuration |
US7670282B2 (en) | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
US7775968B2 (en) | 2004-06-14 | 2010-08-17 | Pneumrx, Inc. | Guided access to lung tissues |
US7766891B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
US7766938B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US20060047291A1 (en) * | 2004-08-20 | 2006-03-02 | Uptake Medical Corporation | Non-foreign occlusion of an airway and lung collapse |
US8167901B2 (en) | 2004-09-27 | 2012-05-01 | Cook Medical Technologies Llc | Removable vena cava filter comprising struts having axial bends |
US9642668B2 (en) | 2004-11-16 | 2017-05-09 | Uptake Medical Technology Inc. | Device and method for lung treatment |
US9050076B2 (en) | 2004-11-16 | 2015-06-09 | Uptake Medical Corp. | Device and method for lung treatment |
US20060161233A1 (en) * | 2004-11-16 | 2006-07-20 | Uptake Medical Corp. | Device and method for lung treatment |
US11839418B2 (en) | 2004-11-16 | 2023-12-12 | Uptake Medical Technology Inc. | Device and method for lung treatment |
EP2545874A1 (en) | 2004-11-16 | 2013-01-16 | Uptake Medical Corp. | Device for lung treatment |
US7913698B2 (en) | 2004-11-16 | 2011-03-29 | Uptake Medical Corp. | Device and method for lung treatment |
WO2006055047A3 (en) * | 2004-11-18 | 2007-03-08 | Mark Adler | Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor |
WO2006055047A2 (en) * | 2004-11-18 | 2006-05-26 | Mark Adler | Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor |
US7451765B2 (en) | 2004-11-18 | 2008-11-18 | Mark Adler | Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor |
US8220460B2 (en) | 2004-11-19 | 2012-07-17 | Portaero, Inc. | Evacuation device and method for creating a localized pleurodesis |
US10034999B2 (en) | 2004-11-23 | 2018-07-31 | Pneumrx, Inc. | Steerable device for accessing a target site and methods |
US9125639B2 (en) | 2004-11-23 | 2015-09-08 | Pneumrx, Inc. | Steerable device for accessing a target site and methods |
US7824366B2 (en) | 2004-12-10 | 2010-11-02 | Portaero, Inc. | Collateral ventilation device with chest tube/evacuation features and method |
US8876791B2 (en) | 2005-02-25 | 2014-11-04 | Pulmonx Corporation | Collateral pathway treatment using agent entrained by aspiration flow current |
US8579893B2 (en) | 2005-08-03 | 2013-11-12 | Tsunami Medtech, Llc | Medical system and method of use |
US8104474B2 (en) | 2005-08-23 | 2012-01-31 | Portaero, Inc. | Collateral ventilation bypass system with retention features |
JP2015083139A (en) * | 2005-10-19 | 2015-04-30 | パルサー バスキュラー インコーポレイテッド | Method and system for endovascularly clipping and repairing lumen and tissue defect |
EP1951129A2 (en) * | 2005-10-19 | 2008-08-06 | Pulsar Vascular, Incorporated | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
US10499927B2 (en) | 2005-10-19 | 2019-12-10 | Pulsar Vascular, Inc. | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
EP1951129A4 (en) * | 2005-10-19 | 2009-12-23 | Pulsar Vascular Inc | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
US8545530B2 (en) | 2005-10-19 | 2013-10-01 | Pulsar Vascular, Inc. | Implantable aneurysm closure systems and methods |
US9510835B2 (en) | 2005-10-19 | 2016-12-06 | Pulsar Vascular, Inc. | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
US8551132B2 (en) | 2005-10-19 | 2013-10-08 | Pulsar Vascular, Inc. | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
US7686013B2 (en) | 2006-01-17 | 2010-03-30 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve |
US7726305B2 (en) | 2006-01-17 | 2010-06-01 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve |
US8740921B2 (en) | 2006-03-13 | 2014-06-03 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8142455B2 (en) | 2006-03-13 | 2012-03-27 | Pneumrx, Inc. | Delivery of minimally invasive lung volume reduction devices |
US8932310B2 (en) | 2006-03-13 | 2015-01-13 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US9402632B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9402971B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US8157837B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US10226257B2 (en) | 2006-03-13 | 2019-03-12 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US10188397B2 (en) | 2006-03-13 | 2019-01-29 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US8282660B2 (en) | 2006-03-13 | 2012-10-09 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US9474533B2 (en) | 2006-03-13 | 2016-10-25 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US9782558B2 (en) | 2006-03-13 | 2017-10-10 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8157823B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8668707B2 (en) | 2006-03-13 | 2014-03-11 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8647392B2 (en) | 2006-03-31 | 2014-02-11 | Spiration, Inc. | Articulable anchor |
US9198669B2 (en) | 2006-03-31 | 2015-12-01 | Spiration, Inc. | Articulable anchor |
US8454708B2 (en) | 2006-03-31 | 2013-06-04 | Spiration, Inc. | Articulable anchor |
US9636207B2 (en) * | 2006-10-31 | 2017-05-02 | Ethicon, Inc. | Implantable repair device |
US20110172786A1 (en) * | 2006-10-31 | 2011-07-14 | Rousseau Robert A | Implantable Repair Device |
US9113858B2 (en) | 2006-11-13 | 2015-08-25 | Uptake Medical Corp. | High pressure and high temperature vapor catheters and systems |
US20080110457A1 (en) * | 2006-11-13 | 2008-05-15 | Uptake Medical Corp. | Treatment with high temperature vapor |
US8585645B2 (en) | 2006-11-13 | 2013-11-19 | Uptake Medical Corp. | Treatment with high temperature vapor |
US7993323B2 (en) | 2006-11-13 | 2011-08-09 | Uptake Medical Corp. | High pressure and high temperature vapor catheters and systems |
US7931641B2 (en) | 2007-05-11 | 2011-04-26 | Portaero, Inc. | Visceral pleura ring connector |
US8163034B2 (en) | 2007-05-11 | 2012-04-24 | Portaero, Inc. | Methods and devices to create a chemically and/or mechanically localized pleurodesis |
US8062315B2 (en) | 2007-05-17 | 2011-11-22 | Portaero, Inc. | Variable parietal/visceral pleural coupling |
US11207118B2 (en) | 2007-07-06 | 2021-12-28 | Tsunami Medtech, Llc | Medical system and method of use |
US10758292B2 (en) | 2007-08-23 | 2020-09-01 | Aegea Medical Inc. | Uterine therapy device and method |
US11213338B2 (en) | 2007-08-23 | 2022-01-04 | Aegea Medical Inc. | Uterine therapy device and method |
US9326873B2 (en) | 2007-10-12 | 2016-05-03 | Spiration, Inc. | Valve loader method, system, and apparatus |
US8136230B2 (en) | 2007-10-12 | 2012-03-20 | Spiration, Inc. | Valve loader method, system, and apparatus |
US8043301B2 (en) | 2007-10-12 | 2011-10-25 | Spiration, Inc. | Valve loader method, system, and apparatus |
US8322335B2 (en) | 2007-10-22 | 2012-12-04 | Uptake Medical Corp. | Determining patient-specific vapor treatment and delivery parameters |
US8147532B2 (en) | 2007-10-22 | 2012-04-03 | Uptake Medical Corp. | Determining patient-specific vapor treatment and delivery parameters |
US8734380B2 (en) | 2007-10-22 | 2014-05-27 | Uptake Medical Corp. | Determining patient-specific vapor treatment and delivery parameters |
US8246672B2 (en) | 2007-12-27 | 2012-08-21 | Cook Medical Technologies Llc | Endovascular graft with separately positionable and removable frame units |
US8231581B2 (en) | 2008-02-19 | 2012-07-31 | Portaero, Inc. | Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease |
US8336540B2 (en) | 2008-02-19 | 2012-12-25 | Portaero, Inc. | Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease |
US8475389B2 (en) | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Methods and devices for assessment of pneumostoma function |
US8464708B2 (en) | 2008-02-19 | 2013-06-18 | Portaero, Inc. | Pneumostoma management system having a cosmetic and/or protective cover |
US8430094B2 (en) | 2008-02-19 | 2013-04-30 | Portaero, Inc. | Flexible pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease |
US8474449B2 (en) | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Variable length pneumostoma management system for treatment of chronic obstructive pulmonary disease |
US8491602B2 (en) | 2008-02-19 | 2013-07-23 | Portaero, Inc. | Single-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease |
US8453638B2 (en) | 2008-02-19 | 2013-06-04 | Portaero, Inc. | One-piece pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease |
US8252003B2 (en) | 2008-02-19 | 2012-08-28 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
US8453637B2 (en) | 2008-02-19 | 2013-06-04 | Portaero, Inc. | Pneumostoma management system for treatment of chronic obstructive pulmonary disease |
US8365722B2 (en) | 2008-02-19 | 2013-02-05 | Portaero, Inc. | Multi-layer pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease |
US7927324B2 (en) | 2008-02-19 | 2011-04-19 | Portaero, Inc. | Aspirator and method for pneumostoma management |
US8347880B2 (en) | 2008-02-19 | 2013-01-08 | Potaero, Inc. | Pneumostoma management system with secretion management features for treatment of chronic obstructive pulmonary disease |
US8506577B2 (en) | 2008-02-19 | 2013-08-13 | Portaero, Inc. | Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease |
US7909803B2 (en) | 2008-02-19 | 2011-03-22 | Portaero, Inc. | Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease |
US8021320B2 (en) | 2008-02-19 | 2011-09-20 | Portaero, Inc. | Self-sealing device and method for delivery of a therapeutic agent through a pneumostoma |
US8348906B2 (en) | 2008-02-19 | 2013-01-08 | Portaero, Inc. | Aspirator for pneumostoma management |
US10595925B2 (en) | 2008-02-20 | 2020-03-24 | Tsunami Medtech, Llc | Medical system and method of use |
US9924992B2 (en) | 2008-02-20 | 2018-03-27 | Tsunami Medtech, Llc | Medical system and method of use |
US11478291B2 (en) | 2008-05-31 | 2022-10-25 | Tsunami Medtech, Llc | Methods for delivering energy into a target tissue of a body |
US11141210B2 (en) | 2008-05-31 | 2021-10-12 | Tsunami Medtech, Llc | Systems and methods for delivering energy into a target tissue of a body |
US11179187B2 (en) | 2008-05-31 | 2021-11-23 | Tsunami Medtech, Llc | Methods for delivering energy into a target tissue of a body |
US11284932B2 (en) | 2008-05-31 | 2022-03-29 | Tsunami Medtech, Llc | Methods for delivering energy into a target tissue of a body |
US11129664B2 (en) | 2008-05-31 | 2021-09-28 | Tsunami Medtech, Llc | Systems and methods for delivering energy into a target tissue of a body |
US8911430B2 (en) | 2008-06-17 | 2014-12-16 | Tsunami Medtech, Llc | Medical probes for the treatment of blood vessels |
US8579888B2 (en) | 2008-06-17 | 2013-11-12 | Tsunami Medtech, Llc | Medical probes for the treatment of blood vessels |
US10285709B2 (en) | 2008-09-05 | 2019-05-14 | Pulsar Vascular, Inc. | Systems and methods for supporting or occluding a physiological opening or cavity |
US11185333B2 (en) | 2008-09-05 | 2021-11-30 | Pulsar Vascular, Inc. | Systems and methods for supporting or occluding a physiological opening or cavity |
US8979893B2 (en) | 2008-09-05 | 2015-03-17 | Pulsar Vascular, Inc. | Systems and methods for supporting or occluding a physiological opening or cavity |
US9615831B2 (en) | 2008-09-05 | 2017-04-11 | Pulsar Vascular, Inc. | Systems and methods for supporting or occluding a physiological opening or cavity |
US8388650B2 (en) | 2008-09-05 | 2013-03-05 | Pulsar Vascular, Inc. | Systems and methods for supporting or occluding a physiological opening or cavity |
US8721632B2 (en) | 2008-09-09 | 2014-05-13 | Tsunami Medtech, Llc | Methods for delivering energy into a target tissue of a body |
US10548653B2 (en) | 2008-09-09 | 2020-02-04 | Tsunami Medtech, Llc | Methods for delivering energy into a target tissue of a body |
US9173669B2 (en) | 2008-09-12 | 2015-11-03 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US10285707B2 (en) | 2008-09-12 | 2019-05-14 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US10058331B2 (en) | 2008-09-12 | 2018-08-28 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US9192403B2 (en) | 2008-09-12 | 2015-11-24 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US10842549B2 (en) | 2008-10-06 | 2020-11-24 | Santa Anna Tech Llc | Vapor ablation system with a catheter having more than one positioning element and configured to treat pulmonary tissue |
US10842548B2 (en) | 2008-10-06 | 2020-11-24 | Santa Anna Tech Llc | Vapor ablation system with a catheter having more than one positioning element |
US9561066B2 (en) | 2008-10-06 | 2017-02-07 | Virender K. Sharma | Method and apparatus for tissue ablation |
US11589920B2 (en) | 2008-10-06 | 2023-02-28 | Santa Anna Tech Llc | Catheter with a double balloon structure to generate and apply an ablative zone to tissue |
US10064697B2 (en) | 2008-10-06 | 2018-09-04 | Santa Anna Tech Llc | Vapor based ablation system for treating various indications |
US11020175B2 (en) | 2008-10-06 | 2021-06-01 | Santa Anna Tech Llc | Methods of ablating tissue using time-limited treatment periods |
US9561067B2 (en) | 2008-10-06 | 2017-02-07 | Virender K. Sharma | Method and apparatus for tissue ablation |
US10695126B2 (en) | 2008-10-06 | 2020-06-30 | Santa Anna Tech Llc | Catheter with a double balloon structure to generate and apply a heated ablative zone to tissue |
US9561068B2 (en) | 2008-10-06 | 2017-02-07 | Virender K. Sharma | Method and apparatus for tissue ablation |
US11779430B2 (en) | 2008-10-06 | 2023-10-10 | Santa Anna Tech Llc | Vapor based ablation system for treating uterine bleeding |
US10842557B2 (en) | 2008-10-06 | 2020-11-24 | Santa Anna Tech Llc | Vapor ablation system with a catheter having more than one positioning element and configured to treat duodenal tissue |
US11813014B2 (en) | 2008-10-06 | 2023-11-14 | Santa Anna Tech Llc | Methods and systems for directed tissue ablation |
US9700365B2 (en) | 2008-10-06 | 2017-07-11 | Santa Anna Tech Llc | Method and apparatus for the ablation of gastrointestinal tissue |
US8246648B2 (en) | 2008-11-10 | 2012-08-21 | Cook Medical Technologies Llc | Removable vena cava filter with improved leg |
US8347881B2 (en) | 2009-01-08 | 2013-01-08 | Portaero, Inc. | Pneumostoma management device with integrated patency sensor and method |
US11284931B2 (en) | 2009-02-03 | 2022-03-29 | Tsunami Medtech, Llc | Medical systems and methods for ablating and absorbing tissue |
US8518053B2 (en) | 2009-02-11 | 2013-08-27 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
US8721734B2 (en) | 2009-05-18 | 2014-05-13 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US11633189B2 (en) | 2009-09-04 | 2023-04-25 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening |
US9277924B2 (en) | 2009-09-04 | 2016-03-08 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening |
US10335153B2 (en) | 2009-09-04 | 2019-07-02 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening |
US8900223B2 (en) | 2009-11-06 | 2014-12-02 | Tsunami Medtech, Llc | Tissue ablation systems and methods of use |
US9161801B2 (en) | 2009-12-30 | 2015-10-20 | Tsunami Medtech, Llc | Medical system and method of use |
US11457969B2 (en) | 2010-08-13 | 2022-10-04 | Tsunami Medtech, Llc | Medical system and method of use |
US10499973B2 (en) | 2010-08-13 | 2019-12-10 | Tsunami Medtech, Llc | Medical system and method of use |
US10238446B2 (en) | 2010-11-09 | 2019-03-26 | Aegea Medical Inc. | Positioning method and apparatus for delivering vapor to the uterus |
US11160597B2 (en) | 2010-11-09 | 2021-11-02 | Aegea Medical Inc. | Positioning method and apparatus for delivering vapor to the uterus |
US10022212B2 (en) | 2011-01-13 | 2018-07-17 | Cook Medical Technologies Llc | Temporary venous filter with anti-coagulant delivery method |
US8795241B2 (en) | 2011-05-13 | 2014-08-05 | Spiration, Inc. | Deployment catheter |
US10624647B2 (en) | 2011-06-03 | 2020-04-21 | Pulsar Vascular, Inc. | Aneurysm devices with additional anchoring mechanisms and associated systems and methods |
US10004510B2 (en) | 2011-06-03 | 2018-06-26 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening, including shock absorbing aneurysm devices |
US11344311B2 (en) | 2011-06-03 | 2022-05-31 | Pulsar Vascular, Inc. | Aneurysm devices with additional anchoring mechanisms and associated systems and methods |
US10426487B2 (en) | 2011-10-05 | 2019-10-01 | Pulsar Vascular, Inc. | Devices, systems and methods for enclosing an anatomical opening |
US9119625B2 (en) | 2011-10-05 | 2015-09-01 | Pulsar Vascular, Inc. | Devices, systems and methods for enclosing an anatomical opening |
US9636117B2 (en) | 2011-10-05 | 2017-05-02 | Pulsar Vascular, Inc. | Devices, systems and methods for enclosing an anatomical opening |
US11457923B2 (en) | 2011-10-05 | 2022-10-04 | Pulsar Vascular, Inc. | Devices, systems and methods for enclosing an anatomical opening |
US10881442B2 (en) | 2011-10-07 | 2021-01-05 | Aegea Medical Inc. | Integrity testing method and apparatus for delivering vapor to the uterus |
GB2513273B (en) * | 2012-02-28 | 2016-03-16 | Spiration Inc | Pulmonary nodule access devices and methods of using the same |
US9259229B2 (en) | 2012-05-10 | 2016-02-16 | Pulsar Vascular, Inc. | Systems and methods for enclosing an anatomical opening, including coil-tipped aneurysm devices |
CN105188599A (en) * | 2013-02-08 | 2015-12-23 | 玛芬股份有限公司 | Peripheral sealing venous check-valve |
US11672584B2 (en) | 2013-03-15 | 2023-06-13 | Tsunami Medtech, Llc | Medical system and method of use |
US9943353B2 (en) | 2013-03-15 | 2018-04-17 | Tsunami Medtech, Llc | Medical system and method of use |
US11413086B2 (en) | 2013-03-15 | 2022-08-16 | Tsunami Medtech, Llc | Medical system and method of use |
US11090102B2 (en) | 2013-10-01 | 2021-08-17 | Uptake Medical Technology Inc. | Preferential volume reduction of diseased segments of a heterogeneous lobe |
US9782211B2 (en) | 2013-10-01 | 2017-10-10 | Uptake Medical Technology Inc. | Preferential volume reduction of diseased segments of a heterogeneous lobe |
US10179019B2 (en) | 2014-05-22 | 2019-01-15 | Aegea Medical Inc. | Integrity testing method and apparatus for delivering vapor to the uterus |
US11219479B2 (en) | 2014-05-22 | 2022-01-11 | Aegea Medical Inc. | Integrity testing method and apparatus for delivering vapor to the uterus |
US10299856B2 (en) | 2014-05-22 | 2019-05-28 | Aegea Medical Inc. | Systems and methods for performing endometrial ablation |
US10575898B2 (en) | 2014-05-22 | 2020-03-03 | Aegea Medical Inc. | Systems and methods for performing endometrial ablation |
US10206686B2 (en) * | 2014-06-10 | 2019-02-19 | Ethicon Llc | Bronchus sealants and methods of sealing bronchial tubes |
US20150351776A1 (en) * | 2014-06-10 | 2015-12-10 | Ethicon Endo-Surgery, Inc. | Bronchus Sealants and Methods of Sealing Bronchial Tubes |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US20160089172A1 (en) * | 2014-09-30 | 2016-03-31 | Boston Scientific Scimed, Inc. | Devices and methods for applying suction |
US10485604B2 (en) | 2014-12-02 | 2019-11-26 | Uptake Medical Technology Inc. | Vapor treatment of lung nodules and tumors |
US10531906B2 (en) | 2015-02-02 | 2020-01-14 | Uptake Medical Technology Inc. | Medical vapor generator |
US20210346144A1 (en) * | 2015-05-18 | 2021-11-11 | Pulmair Medical, Inc. | Implantable Artificial Bronchus And Use Of An Implantable Artificial Bronchus |
US11331037B2 (en) | 2016-02-19 | 2022-05-17 | Aegea Medical Inc. | Methods and apparatus for determining the integrity of a bodily cavity |
US11331140B2 (en) | 2016-05-19 | 2022-05-17 | Aqua Heart, Inc. | Heated vapor ablation systems and methods for treating cardiac conditions |
US11129673B2 (en) | 2017-05-05 | 2021-09-28 | Uptake Medical Technology Inc. | Extra-airway vapor ablation for treating airway constriction in patients with asthma and COPD |
US11344364B2 (en) | 2017-09-07 | 2022-05-31 | Uptake Medical Technology Inc. | Screening method for a target nerve to ablate for the treatment of inflammatory lung disease |
US11350988B2 (en) | 2017-09-11 | 2022-06-07 | Uptake Medical Technology Inc. | Bronchoscopic multimodality lung tumor treatment |
USD845467S1 (en) | 2017-09-17 | 2019-04-09 | Uptake Medical Technology Inc. | Hand-piece for medical ablation catheter |
US11419658B2 (en) | 2017-11-06 | 2022-08-23 | Uptake Medical Technology Inc. | Method for treating emphysema with condensable thermal vapor |
US11490946B2 (en) | 2017-12-13 | 2022-11-08 | Uptake Medical Technology Inc. | Vapor ablation handpiece |
US11806066B2 (en) | 2018-06-01 | 2023-11-07 | Santa Anna Tech Llc | Multi-stage vapor-based ablation treatment methods and vapor generation and delivery systems |
US11864809B2 (en) | 2018-06-01 | 2024-01-09 | Santa Anna Tech Llc | Vapor-based ablation treatment methods with improved treatment volume vapor management |
US11653927B2 (en) | 2019-02-18 | 2023-05-23 | Uptake Medical Technology Inc. | Vapor ablation treatment of obstructive lung disease |
Also Published As
Publication number | Publication date |
---|---|
US20150305749A1 (en) | 2015-10-29 |
US8177805B2 (en) | 2012-05-15 |
US8603127B2 (en) | 2013-12-10 |
US20110283998A1 (en) | 2011-11-24 |
US8926647B2 (en) | 2015-01-06 |
US20120165856A1 (en) | 2012-06-28 |
US20080119866A1 (en) | 2008-05-22 |
US8021385B2 (en) | 2011-09-20 |
US20140128903A1 (en) | 2014-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8603127B2 (en) | Removable anchored lung volume reduction devices and methods | |
US9358013B2 (en) | One-way valve devices for anchored implantation in a lung | |
AU2003225044B2 (en) | Removable anchored lung volume reduction devices and methods | |
US8414655B2 (en) | Removable lung reduction devices, systems, and methods | |
EP2353557B1 (en) | Removable anchored lung volume reduction devices |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SPIRATION, INC., WASHINGTON Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ALFERNESS, CLIFTON A.;REEL/FRAME:012737/0395 Effective date: 20020320 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: GYRUS ACMI, INC., MASSACHUSETTS Free format text: MERGER;ASSIGNOR:SPIRATION, INC.;REEL/FRAME:052401/0484 Effective date: 20200401 |