US20030199831A1 - Catheter anchor system and method - Google Patents

Catheter anchor system and method Download PDF

Info

Publication number
US20030199831A1
US20030199831A1 US10/128,708 US12870802A US2003199831A1 US 20030199831 A1 US20030199831 A1 US 20030199831A1 US 12870802 A US12870802 A US 12870802A US 2003199831 A1 US2003199831 A1 US 2003199831A1
Authority
US
United States
Prior art keywords
catheter
anchor
skull
hole
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/128,708
Inventor
Mary Morris
Duane Frion
Jeff Novotny
Douglas Hankner
Stuart Lahtinen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covestro LLC
Medtronic Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US10/128,708 priority Critical patent/US20030199831A1/en
Priority to AU2003263000A priority patent/AU2003263000A1/en
Priority to PCT/US2003/010087 priority patent/WO2003090820A1/en
Publication of US20030199831A1 publication Critical patent/US20030199831A1/en
Priority to US11/017,336 priority patent/US7270650B2/en
Priority to US11/017,622 priority patent/US7090661B2/en
Assigned to MEDTRONIC, INC. reassignment MEDTRONIC, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HANKNER, DOUGLAS, NOVOTNY, JEFF, LAHTINEN, STUART, FRION, DUANE GERALD, MORRIS, MARY M.
Assigned to BAYER MATERIALSCIENCE LLC reassignment BAYER MATERIALSCIENCE LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WILSON, PATRICIA M., YOURD, RAYMOND A., DOBRANSKY, MICHAEL A.
Priority to US11/855,492 priority patent/US7517337B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1414Hanging-up devices
    • A61M5/1415Stands, brackets or the like for supporting infusion accessories
    • A61M2005/1416Stands, brackets or the like for supporting infusion accessories placed on the body of the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • A61M2025/0213Holding devices, e.g. on the body where the catheter is attached by means specifically adapted to a part of the human body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • A61M2025/024Holding devices, e.g. on the body having a clip or clamp system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • A61M2025/028Holding devices, e.g. on the body having a mainly rigid support structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • A61M2025/0286Holding devices, e.g. on the body anchored in the skin by suture or other skin penetrating devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02Access sites
    • A61M39/0247Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A61M2039/025Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body through bones or teeth, e.g. through the skull
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0687Skull, cranium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0693Brain, cerebrum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1414Hanging-up devices
    • A61M5/1418Clips, separators or the like for supporting tubes or leads
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation

Definitions

  • This application relates generally to implantable catheters, and more particularly to an anchor and method of use for mounting a catheter within a patient, for example, to the skull.
  • IPA intraparenchymal
  • ICV intracerebroventricular
  • ventricles refer to cerebroventricles.
  • intracranial catheters have been anchored to the periosteum, which is a fibrous membrane covering the surface of bone.
  • the periosteum has not provided as much stability as desired, and movement of the catheter anchor may result in changes in the location of the catheter tip.
  • Embodiments of this invention include a catheter system for intracranial delivery, such as intraparenchymal or ventricular delivery, of therapeutic substances to a patient.
  • Embodiments of this system are adapted to anchor a flexible catheter in position relative to the skull for infusion of therapeutic substances, while allowing the anchor to be soft and pliable and thereby less likely to cause skin erosion.
  • These embodiments are further adapted to be anchored to the skull bone rather than fragile periostium.
  • the catheter system generally comprises an elongate catheter (e.g., formed of silicone or polyurethane) having a lumen and at least one drug delivery orifice in fluid communication with the lumen, and an anchor formed of generally flexible, elastomeric material for mounting the catheter to the outer surface of the skull of the patient.
  • the anchor has a through hole for receiving the catheter, and a channel extending substantially from the through hole. A portion of the catheter may be inserted into the channel to retain the portion substantially parallel to the surface of the skull.
  • At least one flange is provided for engaging the outer surface of the skull.
  • At least one substantially rigid standoff is mounted in the flange, with the standoff having an opening for receiving a fastener to fasten the anchor to the skull.
  • the anchor is adapted to flex and comply with adjacent tissue.
  • the generally flexible, elastomeric material of the anchor may comprise silicone.
  • two flanges are provided on the anchor, with at least one standoff mounted in each flange.
  • the standoffs may be insert molded in the flanges of the anchor.
  • the standoffs may be formed of titanium or titanium alloy.
  • the standoffs are preferably substantially annular and have an undercut or circumferential channel helping to retain the standoff in the flange.
  • the anchor has a body in which the through hole and channel are formed, with the body being generally elongate and coaxial with the channel.
  • the body extends in a direction generally perpendicular to the through hole and openings of the standoffs, and the flanges extending substantially in opposite directions substantially perpendicular to the body.
  • the channel is substantially perpendicular to the through hole.
  • an anchor clip is also provided, which is adapted to be fastened to the outer surface of the skull to stabilize the catheter relative to the skull.
  • the anchor clip engages the body of the anchor adjacent the through hole.
  • the anchor clip may be generally V-shaped having two legs each having a free end and a joined end joined with the other leg. The free end of each leg has an opening for receiving a fastener to mount the anchor clip to the skull.
  • the anchor clip also having a slot adjacent the joined ends of the legs for engagement with the anchor to stabilize the anchor.
  • the catheter system is preferably used in combination with an implantable therapeutic substance infusion device, such as an implantable drug pump.
  • the catheter may be directly or indirectly connected with the implantable therapeutic substance infusion device for infusion of therapeutic substance from the implantable therapeutic substance infusion device through the lumen and orifice(s) of the catheter.
  • Indirect connection includes without limitation intermediate connectors or tubing sections.
  • a method of implanting the catheter system comprises: (a) inserting the catheter into the parenchyma or a ventricle; (b) mounting the anchor on the catheter and the skull of a patient to retain the catheter in position; and (c) infusing a therapeutic agent into the parenchyma or a ventricle for treatment of brain tissue.
  • the anchor is mounted on the catheter and the skull of a patient to retain the catheter in position by: (a) inserting the catheter into the through hole of the anchor; (b) sliding the anchor along the catheter into engagement with the skull; (c) inserting a fastener through each opening of the standoff to fasten the anchor to the skull; and (d) placing the anchor in the channel.
  • the catheter may also be sutured in the channel.
  • FIG. 1 illustrates the use of an embodiment of the catheter system in combination with an implantable therapeutic substance infusion device (e.g., drug pump).
  • an implantable therapeutic substance infusion device e.g., drug pump
  • FIG. 2 is a side view of an embodiment of the catheter system.
  • FIG. 3 is a side view of a catheter with portions cut away to illustrate details.
  • FIG. 4 is a perspective view of an embodiment of an anchor of the system.
  • FIG. 5 is another perspective view of an anchor.
  • FIG. 6 is a side elevation of the anchor of FIGS. 4 - 5 with a portion cut away to illustrate details of an embodiment of a rigid standoff.
  • FIGS. 7 and 8 are perspective and cross sectional views of a standoff of FIG. 6.
  • FIG. 9 is a photograph of an embodiment of the catheter system being implanted.
  • FIGS. 10 - 21 are illustrations showing an embodiment the catheter system and a method of implanting the catheter system.
  • FIG. 1 A catheter system 30 of the invention is shown in FIG. 1 in combination with an implantable therapeutic substance infusion device, such as an implantable drug pump 32 (“IDP”).
  • IDP implantable drug pump 32
  • FIG. 1 illustrates use of the catheter system to infuse therapeutic substances stored in the reservoir of the IDP 32 into the parenchyma but the system could also be used to infuse such substances into other regions, such as cerebroventricles.
  • FIG. 2 illustrates further details of the catheter system 30 , which comprises the catheter 34 , anchor 36 and stylet 38 .
  • the stylet 38 provides sufficient rigidity to facilitate handling the catheter 34 , which is preferably very soft and flexible.
  • the stylet 38 is removed after the catheter 34 has been moved into position.
  • Various markings may be provided along the catheter 34 is facilitate positioning and implantation.
  • a preferred catheter 34 for use in the catheter system is the catheter disclosed in U.S. patent application Ser. No. 09/625,751, filed Jul. 26, 2000, which is incorporated herein by reference.
  • FIG. 3 illustrates details of a preferred embodiment of the catheter in which a multiplicity of very small diameter orifices or openings are provided through the wall of the catheter. The preferred orifice arrangement relative to the diameter of the catheter lumen ensures that fluid is delivered fairly evenly across the orifices.
  • the catheter 34 may be formed, for example, of silicone or polyurethane.
  • a preferred embodiment of the anchor 36 comprises a soft, pliable elongate body 40 having a generally circular cross section.
  • a longitudinal channel 42 is provided in the body 40 with a slot 44 open along the top of the channel 42 to allow a catheter 34 to be inserted through the slot 44 into the channel 42 .
  • the catheter-receiving channel 42 is sized, configured and adapted to receive the catheter 34 to hold the catheter 34 generally parallel or tangent to the surface of the skull.
  • Two annular channels 46 may be provided on the body 40 for receiving sutures (not shown) to further lock the catheter 34 in the channel.
  • the anchor 34 is preferably formed of an elastomeric material, such as silicone or polyurethane.
  • a through hole 48 is provided adjacent the proximal end of the body 40 of the anchor 34 .
  • the catheter 32 may be inserted into, and the anchor 34 slide along the catheter 32 , to position the anchor 34 against the skull.
  • the anchor 34 may be positioned adjacent the burr hole and the catheter 32 slide through the through hole 48 of the anchor 34 into position.
  • the anchor 34 may be designed, for example, by the addition of a slit (not shown) to allow the anchor 34 to be attached to the catheter 32 in the lateral or radial direction rather than, or in addition to, being slide longitudinally relative to the catheter 32 .
  • the through hole 48 and channel 42 are substantially oriented at right angles to one another.
  • the longitudinal channel 42 and through hole 48 are connected so that the catheter 32 can be bent at about a right angle to be held in the channel 42 in an orientation generally parallel or tangent to the surface of the skull.
  • At least one flange or tab, but preferably two flanges 50 extend in generally opposite directions from the body 40 .
  • the flanges 50 are integrally molded as one continuous piece with the body 40 .
  • the flanges 50 are set back from the proximal end of the body 40 (i.e. the end with the through hole 48 ) so that the flanges 50 may rest on bone adjacent a burr hole (see, e.g., FIG. 13) with the through hole 48 held over the burr hole.
  • the anchor 34 maintains the through hole 48 substantially at a predetermined orientation and location relative to the skull and burr hole. For example, the through hole 48 is maintained substantially at a perpendicular orientation relative to the plane of the burr hole.
  • At least one generally rigid standoff 52 is provided on each flange 50 as illustrated in FIGS. 4 - 8 .
  • the standoffs 52 are adapted to receive a fastener, such as a surgical screw, to fasten the anchor 34 to bone.
  • the standoffs 52 are formed of material that is much more rigid than the soft, pliable silicone preferred for the anchor 34 . Examples of suitable materials include titanium and titanium allow, although other materials could alternatively be employed.
  • Each standoff 52 is generally cylindrical with an undercut or annular channel provided along the circumferential surface to help lock the standoff 52 on the flange 50 , for example, by insert molding the standoff 52 .
  • the standoffs 52 can be fixed in the flanges 50 by other suitable techniques, including without limitation bonding.
  • Each standoff 52 includes a central bore or opening for receiving a fastener, such as a screw.
  • the through hole 48 constitutes one preferred embodiment of an orienting means for slidably receiving the catheter and orienting the catheter relative to the parenchyma.
  • the longitudinally-extending, catheter-receiving channel 42 constitutes one preferred embodiment of a means, generally adjacent the orienting means, for laterally receiving the catheter to retain a portion of the catheter substantially parallel to the surface of the skull.
  • the flanges 50 constitute a preferred embodiment of a generally flexible skull-engaging means for engaging the outer surface of the skull.
  • the standoffs 52 constitute a preferred embodiment of a substantially rigid means in the skull engaging means for receiving a fastener to fasten the anchor to the skull.
  • An optional anchor clip 54 (see, e.g., FIGS. 14 - 17 ) may also be provided, which is adapted to be fastened to the outer surface of the skull to stabilize the catheter 32 relative to the skull.
  • the anchor clip 54 engages the body 40 of the anchor 34 adjacent the through hole 48 .
  • the body of the anchor 40 preferably includes a downwardly extending annular portion coaxial with the through hole which may be received in a retaining slot 56 in the anchor clip 54 .
  • Suitable materials for the anchor clip include, for example, polysulfone.
  • the anchor clip 54 is generally V-shaped, with two legs 58 each having a free end and a joined end forming an apex of the clip 54 with the other leg.
  • the free end of each leg has an opening 60 for receiving a fastener to mount the anchor clip 54 to the skull.
  • the retaining slot 56 is formed at the apex of the clip 54 adjacent the joined ends of the legs. The retaining slot 56 engages the anchor 34 to stabilize the anchor 34 .
  • FIGS. 10 - 21 illustrate various aspects of a preferred method of implanting a catheter anchor system.
  • this method includes (a) forming (cutting, drilling, etc.) a burr hole through the skull of a patient, and (b) inserting a catheter into the parenchyma or ventricle of the patient.
  • the catheter 32 is preferably soft and conformable, and rigidity is provided temporarily by a rigid stylet to facilitate controlled insertion.
  • imaging and various guidance means such as stereotactic or non-stereotactic frames may be employed.
  • the stylet is removed as illustrated in FIG. 11.
  • a catheter anchor 34 is then placed on the catheter 32 and slide down the catheter 32 into position against the skull as illustrated in FIGS. 12 and 13.
  • the anchor 34 may be positioned adjacent the burr hole and the catheter 32 slide through the through hole 48 of the anchor 34 into position.
  • FIG. 13 illustrates screwing surgical screws through the standoffs 52 to fasten the anchor 34 to the skull.
  • An optional anchor clip 54 is attached to the anchor 34 and skull as illustrated in FIGS. 14 and 15 to help stabilize the proximal end of the anchor 34 to help stabilize the catheter 32 relative to the skull.
  • the catheter 32 is then laid down through the top slot of the anchor 34 into the catheter-receiving channel 42 , and sutures may be employed to retain the catheter 32 in the channel 42 as illustrated in FIGS. 16 and 17.
  • FIGS. 18 - 21 illustrate use of a connector sleeve, connector pin, proximal tubing and sutures to connect the catheter 32 to a implantable drug pump or other implantable therapeutic substance infusion device.

Abstract

A catheter system and method for intracranial infusion of therapeutic substances to a patient. An anchor formed of generally flexible, elastomeric material is used to mount the catheter to the outer surface of the skull of the patient. The anchor has a through hole for receiving the catheter, a channel, extending substantially from the through hole, into which a portion of the catheter may be inserted to retain the portion substantially parallel to the surface of the skull, and at least one flange for engaging the outer surface of the skull. At least one substantially rigid standoff is provided in the flange, with the standoff having an opening for receiving a fastener to fasten the anchor to the skull.

Description

    FIELD OF THE INVENTION
  • This application relates generally to implantable catheters, and more particularly to an anchor and method of use for mounting a catheter within a patient, for example, to the skull. [0001]
  • BACKGROUND OF THE INVENTION
  • Sometimes therapeutic substances, such as drugs, biologics, etc., are infused intraparenchymally or intracerebroventricularly to treat brain disorders, such as malignancies or neurodegenerative diseases. Co-assigned U.S. patent application Ser. No. 09/540,444, filed Mar. 31, 2000, and Ser. No. 09/625,751, filed Jul. 26, 2000, (both incorporated herein by reference) disclose catheters that are particularly well suited for intraparenchymal or intraventricular convection-enhanced infusion of therapeutic substances. As used herein, “IPA” means intraparenchymal, “ICV” means intracerebroventricular, and “intraventricular” and “ventricles” refer to cerebroventricles. [0002]
  • Previously, intracranial catheters have been anchored to the periosteum, which is a fibrous membrane covering the surface of bone. The periosteum has not provided as much stability as desired, and movement of the catheter anchor may result in changes in the location of the catheter tip. [0003]
  • BRIEF SUMMARY OF THE INVENTION
  • Embodiments of this invention include a catheter system for intracranial delivery, such as intraparenchymal or ventricular delivery, of therapeutic substances to a patient. Embodiments of this system are adapted to anchor a flexible catheter in position relative to the skull for infusion of therapeutic substances, while allowing the anchor to be soft and pliable and thereby less likely to cause skin erosion. These embodiments are further adapted to be anchored to the skull bone rather than fragile periostium. [0004]
  • In a first embodiment, the catheter system generally comprises an elongate catheter (e.g., formed of silicone or polyurethane) having a lumen and at least one drug delivery orifice in fluid communication with the lumen, and an anchor formed of generally flexible, elastomeric material for mounting the catheter to the outer surface of the skull of the patient. The anchor has a through hole for receiving the catheter, and a channel extending substantially from the through hole. A portion of the catheter may be inserted into the channel to retain the portion substantially parallel to the surface of the skull. At least one flange is provided for engaging the outer surface of the skull. At least one substantially rigid standoff is mounted in the flange, with the standoff having an opening for receiving a fastener to fasten the anchor to the skull. [0005]
  • Most preferably, the anchor is adapted to flex and comply with adjacent tissue. For example, the generally flexible, elastomeric material of the anchor may comprise silicone. [0006]
  • Preferably, two flanges are provided on the anchor, with at least one standoff mounted in each flange. For example, the standoffs may be insert molded in the flanges of the anchor. The standoffs may be formed of titanium or titanium alloy. The standoffs are preferably substantially annular and have an undercut or circumferential channel helping to retain the standoff in the flange. [0007]
  • Also, preferably, the anchor has a body in which the through hole and channel are formed, with the body being generally elongate and coaxial with the channel. The body extends in a direction generally perpendicular to the through hole and openings of the standoffs, and the flanges extending substantially in opposite directions substantially perpendicular to the body. The channel is substantially perpendicular to the through hole. [0008]
  • In certain embodiments of the invention, an anchor clip is also provided, which is adapted to be fastened to the outer surface of the skull to stabilize the catheter relative to the skull. The anchor clip engages the body of the anchor adjacent the through hole. For example, the anchor clip may be generally V-shaped having two legs each having a free end and a joined end joined with the other leg. The free end of each leg has an opening for receiving a fastener to mount the anchor clip to the skull. The anchor clip also having a slot adjacent the joined ends of the legs for engagement with the anchor to stabilize the anchor. [0009]
  • The catheter system is preferably used in combination with an implantable therapeutic substance infusion device, such as an implantable drug pump. The catheter may be directly or indirectly connected with the implantable therapeutic substance infusion device for infusion of therapeutic substance from the implantable therapeutic substance infusion device through the lumen and orifice(s) of the catheter. Indirect connection includes without limitation intermediate connectors or tubing sections. [0010]
  • In another aspect of the invention, a method of implanting the catheter system comprises: (a) inserting the catheter into the parenchyma or a ventricle; (b) mounting the anchor on the catheter and the skull of a patient to retain the catheter in position; and (c) infusing a therapeutic agent into the parenchyma or a ventricle for treatment of brain tissue. [0011]
  • Preferably, the anchor is mounted on the catheter and the skull of a patient to retain the catheter in position by: (a) inserting the catheter into the through hole of the anchor; (b) sliding the anchor along the catheter into engagement with the skull; (c) inserting a fastener through each opening of the standoff to fasten the anchor to the skull; and (d) placing the anchor in the channel. The catheter may also be sutured in the channel.[0012]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 illustrates the use of an embodiment of the catheter system in combination with an implantable therapeutic substance infusion device (e.g., drug pump). [0013]
  • FIG. 2 is a side view of an embodiment of the catheter system. [0014]
  • FIG. 3 is a side view of a catheter with portions cut away to illustrate details. [0015]
  • FIG. 4 is a perspective view of an embodiment of an anchor of the system. [0016]
  • FIG. 5 is another perspective view of an anchor. [0017]
  • FIG. 6 is a side elevation of the anchor of FIGS. [0018] 4-5 with a portion cut away to illustrate details of an embodiment of a rigid standoff.
  • FIGS. 7 and 8 are perspective and cross sectional views of a standoff of FIG. 6. [0019]
  • FIG. 9 is a photograph of an embodiment of the catheter system being implanted. [0020]
  • FIGS. [0021] 10-21 are illustrations showing an embodiment the catheter system and a method of implanting the catheter system.
  • DETAILED DESCRIPTION OF THE INVENTION
  • A [0022] catheter system 30 of the invention is shown in FIG. 1 in combination with an implantable therapeutic substance infusion device, such as an implantable drug pump 32 (“IDP”). FIG. 1 illustrates use of the catheter system to infuse therapeutic substances stored in the reservoir of the IDP 32 into the parenchyma but the system could also be used to infuse such substances into other regions, such as cerebroventricles.
  • FIG. 2 illustrates further details of the [0023] catheter system 30, which comprises the catheter 34, anchor 36 and stylet 38. The stylet 38 provides sufficient rigidity to facilitate handling the catheter 34, which is preferably very soft and flexible. The stylet 38 is removed after the catheter 34 has been moved into position. Various markings may be provided along the catheter 34 is facilitate positioning and implantation.
  • A [0024] preferred catheter 34 for use in the catheter system is the catheter disclosed in U.S. patent application Ser. No. 09/625,751, filed Jul. 26, 2000, which is incorporated herein by reference. FIG. 3 illustrates details of a preferred embodiment of the catheter in which a multiplicity of very small diameter orifices or openings are provided through the wall of the catheter. The preferred orifice arrangement relative to the diameter of the catheter lumen ensures that fluid is delivered fairly evenly across the orifices. The catheter 34 may be formed, for example, of silicone or polyurethane.
  • As illustrated in FIGS. [0025] 4-6, a preferred embodiment of the anchor 36 comprises a soft, pliable elongate body 40 having a generally circular cross section. A longitudinal channel 42 is provided in the body 40 with a slot 44 open along the top of the channel 42 to allow a catheter 34 to be inserted through the slot 44 into the channel 42. The catheter-receiving channel 42 is sized, configured and adapted to receive the catheter 34 to hold the catheter 34 generally parallel or tangent to the surface of the skull. Two annular channels 46 may be provided on the body 40 for receiving sutures (not shown) to further lock the catheter 34 in the channel. The anchor 34 is preferably formed of an elastomeric material, such as silicone or polyurethane.
  • A through [0026] hole 48 is provided adjacent the proximal end of the body 40 of the anchor 34. The catheter 32 may be inserted into, and the anchor 34 slide along the catheter 32, to position the anchor 34 against the skull. Alternatively, the anchor 34 may be positioned adjacent the burr hole and the catheter 32 slide through the through hole 48 of the anchor 34 into position. In yet another alternative, the anchor 34 may be designed, for example, by the addition of a slit (not shown) to allow the anchor 34 to be attached to the catheter 32 in the lateral or radial direction rather than, or in addition to, being slide longitudinally relative to the catheter 32.
  • The through [0027] hole 48 and channel 42 are substantially oriented at right angles to one another. The longitudinal channel 42 and through hole 48 are connected so that the catheter 32 can be bent at about a right angle to be held in the channel 42 in an orientation generally parallel or tangent to the surface of the skull.
  • At least one flange or tab, but preferably two [0028] flanges 50 extend in generally opposite directions from the body 40. The flanges 50 are integrally molded as one continuous piece with the body 40. The flanges 50 are set back from the proximal end of the body 40 (i.e. the end with the through hole 48) so that the flanges 50 may rest on bone adjacent a burr hole (see, e.g., FIG. 13) with the through hole 48 held over the burr hole. The anchor 34 maintains the through hole 48 substantially at a predetermined orientation and location relative to the skull and burr hole. For example, the through hole 48 is maintained substantially at a perpendicular orientation relative to the plane of the burr hole.
  • At least one generally [0029] rigid standoff 52 is provided on each flange 50 as illustrated in FIGS. 4-8. The standoffs 52 are adapted to receive a fastener, such as a surgical screw, to fasten the anchor 34 to bone. The standoffs 52 are formed of material that is much more rigid than the soft, pliable silicone preferred for the anchor 34. Examples of suitable materials include titanium and titanium allow, although other materials could alternatively be employed. Each standoff 52 is generally cylindrical with an undercut or annular channel provided along the circumferential surface to help lock the standoff 52 on the flange 50, for example, by insert molding the standoff 52. Alternatively, the standoffs 52 can be fixed in the flanges 50 by other suitable techniques, including without limitation bonding. Each standoff 52 includes a central bore or opening for receiving a fastener, such as a screw.
  • The through [0030] hole 48 constitutes one preferred embodiment of an orienting means for slidably receiving the catheter and orienting the catheter relative to the parenchyma. The longitudinally-extending, catheter-receiving channel 42 constitutes one preferred embodiment of a means, generally adjacent the orienting means, for laterally receiving the catheter to retain a portion of the catheter substantially parallel to the surface of the skull.
  • The [0031] flanges 50 constitute a preferred embodiment of a generally flexible skull-engaging means for engaging the outer surface of the skull. The standoffs 52 constitute a preferred embodiment of a substantially rigid means in the skull engaging means for receiving a fastener to fasten the anchor to the skull.
  • An optional anchor clip [0032] 54 (see, e.g., FIGS. 14-17) may also be provided, which is adapted to be fastened to the outer surface of the skull to stabilize the catheter 32 relative to the skull. The anchor clip 54 engages the body 40 of the anchor 34 adjacent the through hole 48. The body of the anchor 40 preferably includes a downwardly extending annular portion coaxial with the through hole which may be received in a retaining slot 56 in the anchor clip 54. Suitable materials for the anchor clip include, for example, polysulfone.
  • Most preferably, the [0033] anchor clip 54 is generally V-shaped, with two legs 58 each having a free end and a joined end forming an apex of the clip 54 with the other leg. The free end of each leg has an opening 60 for receiving a fastener to mount the anchor clip 54 to the skull. The retaining slot 56 is formed at the apex of the clip 54 adjacent the joined ends of the legs. The retaining slot 56 engages the anchor 34 to stabilize the anchor 34.
  • FIGS. [0034] 10-21 illustrate various aspects of a preferred method of implanting a catheter anchor system. As illustrated in FIG. 10, this method includes (a) forming (cutting, drilling, etc.) a burr hole through the skull of a patient, and (b) inserting a catheter into the parenchyma or ventricle of the patient. The catheter 32 is preferably soft and conformable, and rigidity is provided temporarily by a rigid stylet to facilitate controlled insertion. In addition, imaging and various guidance means, such as stereotactic or non-stereotactic frames may be employed. After the catheter 32 is in position, the stylet is removed as illustrated in FIG. 11.
  • A [0035] catheter anchor 34 is then placed on the catheter 32 and slide down the catheter 32 into position against the skull as illustrated in FIGS. 12 and 13. Alternatively, the anchor 34 may be positioned adjacent the burr hole and the catheter 32 slide through the through hole 48 of the anchor 34 into position. FIG. 13 illustrates screwing surgical screws through the standoffs 52 to fasten the anchor 34 to the skull.
  • An [0036] optional anchor clip 54 is attached to the anchor 34 and skull as illustrated in FIGS. 14 and 15 to help stabilize the proximal end of the anchor 34 to help stabilize the catheter 32 relative to the skull.
  • The [0037] catheter 32 is then laid down through the top slot of the anchor 34 into the catheter-receiving channel 42, and sutures may be employed to retain the catheter 32 in the channel 42 as illustrated in FIGS. 16 and 17.
  • FIGS. [0038] 18-21 illustrate use of a connector sleeve, connector pin, proximal tubing and sutures to connect the catheter 32 to a implantable drug pump or other implantable therapeutic substance infusion device.
  • Thus, embodiments of the catheter anchor system and method are disclosed. One skilled in the art will appreciate that the present invention can be practiced with embodiments other than those disclosed. The disclosed embodiments are presented for purposes of illustration and not limitation, and the present invention is limited only by the claims that follow. [0039]

Claims (27)

What is claimed is:
1. A catheter system for intracranial delivery of therapeutic substances to a patient, the system comprising:
an elongate catheter having a lumen and at least one drug delivery orifice in fluid communication with the lumen;
an anchor formed of generally flexible, elastomeric material for mounting the catheter to the outer surface of the skull of the patient, the anchor having:
a through hole for receiving the catheter,
a channel, extending substantially from the through hole, into which a portion of the catheter may be inserted to retain the portion substantially parallel to the surface of the skull;
at least one flange for engaging the outer surface of the skull; and
at least one substantially rigid standoff mounted in the flange, the standoff having an opening for receiving a fastener to fasten the anchor to the skull.
2. The catheter system of claim 1 in which the at least one flange comprises two flanges extending in opposite directions from the channel, the at least one substantially rigid standoff comprising at least one standoff mounted in each flange.
3. The catheter system of claim 2 in which the channel is substantially perpendicular to the through hole.
4. The catheter system of claim 3 in which the generally flexible, elastomeric material comprises silicone.
5. The catheter system of claim 4 in which the anchor is adapted to flex and comply with adjacent tissue.
6. The catheter system of claim 5 in which the standoffs are insert molded in the flanges of the anchor.
7. The catheter system of claim 6 in which the standoffs are formed of titanium or titanium alloy.
8. The catheter system of claim 7 in which the standoffs are substantially annular and have an undercut or circumferential channel helping to retain the standoff in the flange.
9. The catheter system of claim 7 in which the anchor has a body in which the through hole and channel are formed, the body being generally elongate and coaxial with the channel, the body extending in a direction generally perpendicular to the through hole and openings of the standoffs, the flanges extending substantially in opposite directions substantially perpendicular to the body.
10. The catheter system of claim 9 further comprising an anchor clip adapted to engage the body of the anchor adjacent the through hole, the anchor clip being adapted to be fastened to the outer surface of the skull to stabilize the catheter relative to the skull.
11. The catheter system of claim 10 in which the anchor clip is generally V-shaped having two legs each having a free end and a joined end joined with the other leg, the free end of each leg having an opening for receiving a fastener to mount the anchor clip to the skull, the anchor clip having a slot adjacent the joined ends of the legs for engagement with the anchor to stabilize the anchor.
12. The catheter system of claim 11 in which the anchor clip is formed of polysulfone
13. The catheter system of claim 1 in which the catheter is formed of silicone or polyurethane.
14. A combination of the catheter system of any of claims 1-13 with an implantable therapeutic substance infusion device, the catheter being directly or indirectly connected with the implantable therapeutic substance infusion device for infusion of therapeutic substance from the implantable therapeutic substance infusion device through the lumen and orifice(s) of the catheter.
15. A method of use of the catheter system of claim 1, the method comprising:
inserting the catheter into the parenchyma or a ventricle;
mounting the anchor on the catheter and the skull of a patient to retain the catheter in position; and
infusing a therapeutic agent into the parenchyma or a ventricle for treatment of brain tissue.
16. The method of claim 15 in which the step of mounting the anchor on the catheter and the skull of a patient to retain the catheter in position includes:
inserting the catheter into the through hole of the anchor;
sliding the anchor along the catheter into engagement with the skull;
inserting a fastener through the opening of each standoff to fasten the anchor to the skull; and
placing the catheter in the channel.
17. The method of claim 16 in which the step of mounting the anchor on the catheter and the skull of a patient to retain the catheter in position further includes:
suturing the catheter in the channel.
18. A system for intracranial delivery of therapeutic substances to a patient, the system comprising:
an elongate catheter having a lumen and at least one drug delivery orifice in fluid communication with the lumen;
an anchor formed of generally flexible, elastomeric material for mounting the catheter to the outer surface of the skull of the patient, the anchor having:
a through hole for receiving the catheter,
a channel, extending substantially from the through hole, into which a portion of the catheter may be inserted to retain the portion substantially parallel to the surface of the skull;
at least one flange for engaging the outer surface of the skull; and
at least one substantially rigid standoff mounted in the flange, the standoff having an opening for receiving a fastener to fasten the anchor to the skull; and
an implantable therapeutic substance infusion device, the catheter being directly or indirectly connected with the implantable therapeutic substance infusion device for infusion of therapeutic substance from the implantable therapeutic substance infusion device through the lumen and orifice(s) of the catheter.
19. A catheter system for intracranial delivery of therapeutic substances to a patient, the system comprising:
an elongate catheter having a lumen and at least one drug delivery orifice in fluid communication with the lumen;
an anchor formed of generally flexible, elastomeric material for mounting the catheter to the outer surface of the skull of the patient, the anchor including:
orienting means for slidably receiving the catheter and orienting the catheter relative to the parenchyma;
means, generally adjacent the orienting means, for laterally receiving the catheter to retain a portion of the catheter substantially parallel to the surface of the skull;
generally flexible skull-engaging means for engaging the outer surface of the skull; and
substantially rigid means in the skull engaging means for receiving a fastener to fasten the anchor to the skull.
20. A method of implanting a catheter for intracranial delivery of therapeutic substances to a patient, the method comprising:
forming a burr hole through the skull of the patient;
inserting the catheter through the burr hole into the parenchyma or a ventricle;
mounting an generally soft and pliable anchor on the catheter and moving the anchor along the catheter into engagement with the skull of a patient to retain the catheter in position, the anchor being formed of generally soft and pliable material and having at least one generally rigid standoff for receiving a screw or other fastener;
inserting a fastener through the opening of the standoff to fasten the anchor to the skull;
inserting a portion of the catheter laterally into a channel in the anchor to orient the portion of the catheter generally parallel to the surface of the skull; and
infusing a therapeutic agent into the parenchyma or a ventricle for treatment of brain tissue.
21. The method of claim 20 in which the step of mounting the anchor on the catheter and the skull of a patient to retain the catheter in position further includes:
suturing the catheter in the channel.
22. The method of claim 20 further comprising the step of directly or indirectly connecting the catheter to an implantable therapeutic substance infusion device.
23. A method of implanting a catheter for intracranial delivery of therapeutic substances to a patient, the method comprising:
forming a burr hole through the skull of the patient;
placing a generally soft and pliable anchor adjacent the burr hole with the burr hole overlapping a through hole in the anchor, the anchor being formed of generally soft and pliable material and having at least one generally rigid standoff for receiving a screw or other fastener;
inserting the catheter through the through hole and burr hole into the parenchyma or a ventricle;
inserting a fastener through the opening of the standoff to fasten the anchor to the skull;
inserting a portion of the catheter laterally into a channel in the anchor to orient the portion of the catheter generally parallel to the surface of the skull; and
infusing a therapeutic agent into the parenchyma or a ventricle for treatment of brain tissue.
24. The method of claim 23 further comprising the step of suturing the catheter in the channel.
25. The method of claim 23 further comprising the step of directly or indirectly connecting the catheter to an implantable therapeutic substance infusion device.
26. The method of claim 23 wherein the step of inserting a fastener through the opening of the standoff to fasten the anchor to the skull is carried out before the step of inserting the catheter through the through hole and burr hole into the parenchyma or a ventricle.
27. The method of claim 23 wherein the step of inserting a fastener through the opening of the standoff to fasten the anchor to the skull is carried out after the step of inserting the catheter through the through hole and burr hole into the parenchyma or a ventricle.
US10/128,708 2002-04-23 2002-04-23 Catheter anchor system and method Abandoned US20030199831A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/128,708 US20030199831A1 (en) 2002-04-23 2002-04-23 Catheter anchor system and method
AU2003263000A AU2003263000A1 (en) 2002-04-23 2003-04-02 Catheter anchor system
PCT/US2003/010087 WO2003090820A1 (en) 2002-04-23 2003-04-02 Catheter anchor system
US11/017,336 US7270650B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method
US11/017,622 US7090661B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method
US11/855,492 US7517337B2 (en) 2002-04-23 2007-09-14 Catheter anchor system and method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/128,708 US20030199831A1 (en) 2002-04-23 2002-04-23 Catheter anchor system and method

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/017,622 Continuation US7090661B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method
US11/017,336 Continuation US7270650B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method

Publications (1)

Publication Number Publication Date
US20030199831A1 true US20030199831A1 (en) 2003-10-23

Family

ID=29215498

Family Applications (4)

Application Number Title Priority Date Filing Date
US10/128,708 Abandoned US20030199831A1 (en) 2002-04-23 2002-04-23 Catheter anchor system and method
US11/017,622 Expired - Lifetime US7090661B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method
US11/017,336 Expired - Lifetime US7270650B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method
US11/855,492 Expired - Lifetime US7517337B2 (en) 2002-04-23 2007-09-14 Catheter anchor system and method

Family Applications After (3)

Application Number Title Priority Date Filing Date
US11/017,622 Expired - Lifetime US7090661B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method
US11/017,336 Expired - Lifetime US7270650B2 (en) 2002-04-23 2004-12-20 Catheter anchor system and method
US11/855,492 Expired - Lifetime US7517337B2 (en) 2002-04-23 2007-09-14 Catheter anchor system and method

Country Status (3)

Country Link
US (4) US20030199831A1 (en)
AU (1) AU2003263000A1 (en)
WO (1) WO2003090820A1 (en)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137134A1 (en) * 2003-02-24 2005-06-23 North Bristol N.H.S. Trust Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US20050182421A1 (en) * 2004-02-13 2005-08-18 Schulte Gregory T. Methods and apparatus for securing a therapy delivery device within a burr hole
US20080103456A1 (en) * 2006-10-30 2008-05-01 Johnson Benjamin A Infusion catheter
US20090143764A1 (en) * 2007-11-30 2009-06-04 Medtronic, Inc. Infusion catheter assembly with reduced backflow
US20090187149A1 (en) * 2008-01-22 2009-07-23 Medtronic, Inc. Burr hole anchors, systems, and methods
US20100179563A1 (en) * 2002-09-17 2010-07-15 Medtronic, Inc. Low Profile Instrument Immobilizer
US20120059285A1 (en) * 2010-08-27 2012-03-08 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US8738151B2 (en) 2010-04-28 2014-05-27 Medtronic, Inc. Body portal anchors and systems
US8845656B2 (en) 2000-04-07 2014-09-30 Medtronic, Inc. Device for immobilizing a primary instrument and method therefor
US9302043B2 (en) 2013-03-12 2016-04-05 Medtronic, Inc. Socketed portal anchors and methods of using same
US9352125B2 (en) 2013-03-12 2016-05-31 Medtronic, Inc. Portal anchors incorporating strain relief cup and systems using same
US9579494B2 (en) 2013-03-14 2017-02-28 Ekos Corporation Method and apparatus for drug delivery to a target site
USD793549S1 (en) 2016-05-04 2017-08-01 DePuy Synthes Products, Inc. Catheter clip
US20180042648A1 (en) * 2004-08-03 2018-02-15 Albany Medical College Device and method for correcting a spinal deformity
US10076387B2 (en) 2015-06-18 2018-09-18 Medtronic, Inc. Medical device implantation and positioning system
US10252032B2 (en) 2013-03-12 2019-04-09 Medtronic, Inc. Socketed portal anchors and methods of using same
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
US10926074B2 (en) 2001-12-03 2021-02-23 Ekos Corporation Catheter with multiple ultrasound radiating members
WO2021040818A1 (en) * 2019-08-28 2021-03-04 Infinivation Biomedical Llc Medical device anchor
WO2021195225A1 (en) * 2020-03-24 2021-09-30 The Penn State Research Foundation Surgical method, device, system and kit for the treatment of hydrocephalus
US11298041B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
CN115040756A (en) * 2022-08-16 2022-09-13 生一科技(北京)有限公司 Catheter supporting device and lumen intervention system
US11497576B2 (en) 2017-07-17 2022-11-15 Voyager Therapeutics, Inc. Trajectory array guide system
US11672553B2 (en) 2007-06-22 2023-06-13 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US11925367B2 (en) 2018-12-20 2024-03-12 Ekos Corporation Power parameters for ultrasonic catheter

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030199831A1 (en) * 2002-04-23 2003-10-23 Morris Mary M. Catheter anchor system and method
US8430852B2 (en) 2007-04-17 2013-04-30 Medtronic, Inc. Therapeutic sleeve for implantable medical device
WO2008131405A1 (en) * 2007-04-23 2008-10-30 Cerebro Dynamics, Inc. Securement device for shunt catheter and implantation method therefor
US20080275401A1 (en) * 2007-05-01 2008-11-06 Sage Shahn S Catheter anchor and system/method regarding same
US8323654B2 (en) * 2007-05-14 2012-12-04 Medtronic, Inc. Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
WO2008141321A1 (en) 2007-05-14 2008-11-20 Medtronic, Inc. Methods and device to neutralize soluble toxic agents in the brain
US8262624B2 (en) 2008-03-27 2012-09-11 Medtronic, Inc. Anchor and anchor deployment apparatus
US8632502B2 (en) 2008-03-27 2014-01-21 Medtronic, Inc. Anchor deployment apparatus
US8202531B2 (en) * 2008-07-23 2012-06-19 Warsaw Orthopedic, Inc. Drug depots having one or more anchoring members
US8043304B2 (en) * 2008-07-24 2011-10-25 Boston Scientific Neuromodulation Corporation Cam lock burr hole plug for securing retainer/plug base
US8425534B2 (en) 2008-07-24 2013-04-23 Boston Scientific Neuromodulation Corporation Cam lock burr hole plug for securing stimulation lead
EP2376172B1 (en) * 2009-01-12 2014-07-23 Becton, Dickinson and Company Systems and methods for providing a convection-enhanced delivery device
US20100280531A1 (en) * 2009-04-30 2010-11-04 Medtronic, Inc. Snap-on suture ring for implantable medical device
WO2011011497A1 (en) * 2009-07-21 2011-01-27 North Richard B Spinal cord stimulation lead anchor
US8323249B2 (en) 2009-08-14 2012-12-04 The Regents Of The University Of Michigan Integrated vascular delivery system
EP2519212A1 (en) * 2009-12-30 2012-11-07 Cook Medical Technologies LLC Gastric port system
WO2011146772A1 (en) 2010-05-19 2011-11-24 Tangent Medical Technologies Llc Safety needle system operable with a medical device
WO2011146769A2 (en) 2010-05-19 2011-11-24 Tangent Medical Technologies Llc Integrated vascular delivery system
CA2912238C (en) 2010-09-08 2019-07-09 Covidien Lp Catheter with imaging assembly
WO2012103123A2 (en) 2011-01-28 2012-08-02 Medtronic, Inc. Repositionable therapy delivery element anchor
EP3881876A1 (en) 2011-08-01 2021-09-22 Alcyone Lifesciences, Inc. Microfluidic drug delivery devices
US8954165B2 (en) 2012-01-25 2015-02-10 Nevro Corporation Lead anchors and associated systems and methods
US9198835B2 (en) 2012-09-07 2015-12-01 Covidien Lp Catheter with imaging assembly with placement aid and related methods therefor
USD716841S1 (en) 2012-09-07 2014-11-04 Covidien Lp Display screen with annotate file icon
USD717340S1 (en) 2012-09-07 2014-11-11 Covidien Lp Display screen with enteral feeding icon
US9517184B2 (en) 2012-09-07 2016-12-13 Covidien Lp Feeding tube with insufflation device and related methods therefor
USD735343S1 (en) 2012-09-07 2015-07-28 Covidien Lp Console
US9308022B2 (en) 2012-12-10 2016-04-12 Nevro Corporation Lead insertion devices and associated systems and methods
US9919129B2 (en) 2012-12-18 2018-03-20 Alcyone Lifesciences, Inc. Systems and methods for reducing or preventing backflow in a delivery system
WO2014204954A1 (en) 2013-06-17 2014-12-24 Alcyone Lifesciences, Inc. Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters
US9265935B2 (en) 2013-06-28 2016-02-23 Nevro Corporation Neurological stimulation lead anchors and associated systems and methods
JP6498670B2 (en) 2013-07-31 2019-04-10 アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. Systems and methods for drug delivery, therapy, and monitoring
WO2015077796A1 (en) 2013-11-25 2015-05-28 Racz N Sandor Anchor elements, medical devices including one or more anchor elements and related assemblies and methods
AU2015214400B2 (en) 2014-02-04 2019-10-03 Icu Medical, Inc. Self-priming systems and methods
US10806396B2 (en) 2015-01-26 2020-10-20 Alcyone Lifesciences, Inc. Drug delivery methods with tracer
WO2016189391A2 (en) * 2015-05-28 2016-12-01 4Tech Inc. Off-center tissue anchors with tension members
US10232169B2 (en) 2015-07-23 2019-03-19 Boston Scientific Neuromodulation Corporation Burr hole plugs for electrical stimulation systems and methods of making and using
WO2017048992A1 (en) 2015-09-15 2017-03-23 Racz N Sandor Deployment devices and related assemblies and methods
EP3399922A4 (en) 2016-01-04 2019-08-07 Alcyone Lifesciences, Inc. Methods and devices for treating stroke
WO2018132708A1 (en) 2017-01-12 2018-07-19 Tc1 Llc Percutaneous driveline anchor devices and methods of use
WO2018132713A1 (en) * 2017-01-12 2018-07-19 Tc1 Llc Driveline bone anchors and methods of use
WO2018165391A1 (en) 2017-03-09 2018-09-13 Nevro Corp. Paddle leads and delivery tools, and associated systems and methods
EP3710105B1 (en) 2017-11-13 2023-10-04 Boston Scientific Neuromodulation Corporation Systems for making and using a low-profile control module for an electrical stimulation system
WO2019143574A1 (en) 2018-01-16 2019-07-25 Boston Scientific Neuromodulation Corporation An electrical stimulation system with a case-neutral battery and a control module for such a system
EP3762087B1 (en) 2018-03-09 2023-04-26 Boston Scientific Neuromodulation Corporation Burr hole plugs for electrical stimulation systems
WO2019178145A1 (en) 2018-03-16 2019-09-19 Boston Scientific Neuromodulation Corporation Kits and methods for securing a burr hole plugs for stimulation systems
US11420045B2 (en) 2018-03-29 2022-08-23 Nevro Corp. Leads having sidewall openings, and associated systems and methods
WO2022081650A1 (en) * 2020-10-14 2022-04-21 Opcare Llc Improved catheter anchor apparatus and methods

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444861A (en) * 1966-03-15 1969-05-20 Rudolf R Schulte Drain tube with adjusting friction lock
US4645492A (en) * 1983-10-11 1987-02-24 Medical Engineering Corporation Catheter anchoring device
US5916200A (en) * 1997-10-01 1999-06-29 Walter Lorenz Surgical, Inc. Apparatus and method for stabilization of a cranial shunt
US6093180A (en) * 1995-04-28 2000-07-25 Medtronic, Inc. Intraparenchymal infusion catheter system
US6551290B1 (en) * 2000-03-31 2003-04-22 Medtronic, Inc. Catheter for target specific drug delivery
US6719727B2 (en) * 2001-05-25 2004-04-13 Becton Dickinson And Company Catheter having a wing with a stiffening member therein

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250880A (en) 1979-06-08 1981-02-17 Whitman Medical Corporation Stabilizing fitting for an intravenous catheter
US4276882A (en) 1979-05-18 1981-07-07 Medtronic, Inc. Lead anchoring device
US4328813A (en) * 1980-10-20 1982-05-11 Medtronic, Inc. Brain lead anchoring system
US4382445A (en) 1980-12-04 1983-05-10 Cosmos Research Associates Physiological fluid shunt system and improvements therefor
US4435174A (en) * 1982-04-12 1984-03-06 American Hospital Supply Corporation Catheter guide
US4569675A (en) * 1983-09-12 1986-02-11 Infusaid Corporation Transcutaneous infusion system
US5036862A (en) * 1987-04-06 1991-08-06 Cordis Corporation Implantable, self-retaining lead
US4976680A (en) * 1988-10-07 1990-12-11 Hayman Michael H Apparatus for in situ radiotherapy
US5183455A (en) * 1988-10-07 1993-02-02 Omnitron International, Inc. Apparatus for in situ radiotherapy
US5158097A (en) * 1990-06-08 1992-10-27 Allegheny-Singer Research Institute Paraneural stimulating lead
US5267969A (en) * 1992-10-08 1993-12-07 Abbott Laboratories External retaining device for feeding tube or the like
US5344439A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Catheter with retractable anchor mechanism
US6827705B2 (en) * 1993-03-19 2004-12-07 Venetec International, Inc. Catheter anchoring system
US6786892B2 (en) * 1993-03-19 2004-09-07 Venetec International, Inc. Catheter anchoring system
US5364367A (en) * 1993-04-30 1994-11-15 Minnesota Mining And Manufacturing Company Cannula anchor
US5376108A (en) * 1993-05-20 1994-12-27 Telectronics Pacing Systems, Inc. Electrode lead anchoring apparatus and method employing dual suture collars
US5484445A (en) 1993-10-12 1996-01-16 Medtronic, Inc. Sacral lead anchoring system
US5464446A (en) 1993-10-12 1995-11-07 Medtronic, Inc. Brain lead anchoring system
US5927277A (en) * 1995-04-28 1999-07-27 Medtronic, Inc. Method and apparatus for securing probes within a burr hole
US5584874A (en) 1995-04-28 1996-12-17 Medtronic, Inc. Medical electrical lead having improved anchoring sleeve
US5954687A (en) 1995-04-28 1999-09-21 Medtronic, Inc. Burr hole ring with catheter for use as an injection port
US5662600A (en) * 1995-09-29 1997-09-02 Pudenz-Schulte Medical Research Corporation Burr-hole flow control device
US5810781A (en) 1995-10-24 1998-09-22 Venetec International, Inc. Catheter fitting securement device
US5722959A (en) * 1995-10-24 1998-03-03 Venetec International, Inc. Catheter securement device
US5865842A (en) 1996-08-29 1999-02-02 Medtronic, Inc. System and method for anchoring brain stimulation lead or catheter
US5961519A (en) * 1997-04-11 1999-10-05 Kinamed, Inc. Burr hole cover for cranial surgery
US5865843A (en) 1997-04-23 1999-02-02 Medtronic Inc. Medical neurological lead with integral fixation mechanism
US5843146A (en) 1997-04-30 1998-12-01 Medtronic Incorporated Adjustable medical lead anchor
US5843150A (en) * 1997-10-08 1998-12-01 Medtronic, Inc. System and method for providing electrical and/or fluid treatment within a patient's brain
US6044304A (en) 1998-04-29 2000-03-28 Medtronic, Inc. Burr ring with integral lead/catheter fixation device
US6491664B2 (en) 1998-08-18 2002-12-10 Venetec International, Inc. Anchoring system for a medical article
US6332874B1 (en) * 1998-08-28 2001-12-25 C.R. Bard, Inc. Coupling and stabilization system for proximal end of catheter
US6482182B1 (en) * 1998-09-03 2002-11-19 Surgical Navigation Technologies, Inc. Anchoring system for a brain lead
US6321104B1 (en) 1998-11-05 2001-11-20 Medtronic, Inc. Burr hole cap for fixation of cranial lead
US6554802B1 (en) 1999-03-31 2003-04-29 Medtronic, Inc. Medical catheter anchor
DE10015323A1 (en) * 1999-03-31 2000-11-16 Medtronic Inc Anchor to hold a catheter in place at body tissue has a tube with a channel through it to take the catheter and projecting side wings to be held together by a thread for fixing in position
US6210417B1 (en) 1999-04-29 2001-04-03 Medtronic, Inc. Medical lead positioning and anchoring system
US6134477A (en) * 1999-04-30 2000-10-17 Medtronic, Inc. Adjustable medical lead fixation system
US6482183B1 (en) * 2000-05-10 2002-11-19 Gudrun Pausch Apparatus for the fixation of a percutaneous flexible line
AU2001285071A1 (en) * 2000-08-17 2002-02-25 John David Trajectory guide with instrument immobilizer
US6551200B1 (en) * 2001-10-19 2003-04-22 Taylor Made Golf Company, Inc. Golf club head
US20030199831A1 (en) * 2002-04-23 2003-10-23 Morris Mary M. Catheter anchor system and method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444861A (en) * 1966-03-15 1969-05-20 Rudolf R Schulte Drain tube with adjusting friction lock
US4645492A (en) * 1983-10-11 1987-02-24 Medical Engineering Corporation Catheter anchoring device
US6093180A (en) * 1995-04-28 2000-07-25 Medtronic, Inc. Intraparenchymal infusion catheter system
US5916200A (en) * 1997-10-01 1999-06-29 Walter Lorenz Surgical, Inc. Apparatus and method for stabilization of a cranial shunt
US6551290B1 (en) * 2000-03-31 2003-04-22 Medtronic, Inc. Catheter for target specific drug delivery
US6719727B2 (en) * 2001-05-25 2004-04-13 Becton Dickinson And Company Catheter having a wing with a stiffening member therein

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911452B2 (en) 2000-04-07 2014-12-16 Medtronic, Inc. Device for immobilizing a primary instrument and method therefor
US8845656B2 (en) 2000-04-07 2014-09-30 Medtronic, Inc. Device for immobilizing a primary instrument and method therefor
US10300268B2 (en) 2000-04-07 2019-05-28 Medtronic, Inc. Device for immobilizing a primary instrument and method therefor
US10926074B2 (en) 2001-12-03 2021-02-23 Ekos Corporation Catheter with multiple ultrasound radiating members
US10058681B2 (en) 2002-09-17 2018-08-28 Medtronic, Inc. Low profile instrument immobilizer
US20100179563A1 (en) * 2002-09-17 2010-07-15 Medtronic, Inc. Low Profile Instrument Immobilizer
US10974029B2 (en) 2002-09-17 2021-04-13 Medtronic, Inc. Low profile instrument immobilizer
US9901713B2 (en) 2002-09-17 2018-02-27 Medtronic, Inc. Low profile instrument immobilizer
US8946152B2 (en) 2003-02-24 2015-02-03 Amgen Inc. Method of treating parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US20050137134A1 (en) * 2003-02-24 2005-06-23 North Bristol N.H.S. Trust Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US20050182464A1 (en) * 2004-02-13 2005-08-18 Schulte Gregory T. Methods and apparatus for securing a therapy delivery device within a burr hole
US7580756B2 (en) 2004-02-13 2009-08-25 Medtronic, Inc. Methods and apparatus for securing a therapy delivery device within a burr hole
US7604644B2 (en) 2004-02-13 2009-10-20 Medtronic, Inc. Apparatus for securing a therapy delivery device within a burr hole
US10086193B2 (en) 2004-02-13 2018-10-02 Medtronic, Inc. Apparatus for securing a therapy delivery device within a burr hole and method for making same
US20050182422A1 (en) * 2004-02-13 2005-08-18 Schulte Gregory T. Apparatus for securing a therapy delivery device within a burr hole and method for making same
US20050182425A1 (en) * 2004-02-13 2005-08-18 Schulte Gregory T. Methods and apparatus for securing a therapy delivery device within a burr hole
US20050182420A1 (en) * 2004-02-13 2005-08-18 Schulte Gregory T. Low profile apparatus for securing a therapy delivery device within a burr hole
US20050182423A1 (en) * 2004-02-13 2005-08-18 Schulte Gregory T. Methods and apparatus for securing a therapy delivery device within a burr hole
US20050182421A1 (en) * 2004-02-13 2005-08-18 Schulte Gregory T. Methods and apparatus for securing a therapy delivery device within a burr hole
US10512490B2 (en) * 2004-08-03 2019-12-24 Albany Medical College Device and method for correcting a spinal deformity
US20180042648A1 (en) * 2004-08-03 2018-02-15 Albany Medical College Device and method for correcting a spinal deformity
US7988674B2 (en) 2006-10-30 2011-08-02 Medtronic, Inc. Externally releasable body portal anchors and systems
US20080103456A1 (en) * 2006-10-30 2008-05-01 Johnson Benjamin A Infusion catheter
US20080172068A1 (en) * 2006-10-30 2008-07-17 Adams Matthew H Externally releasable body portal anchors and systems
US8945089B2 (en) 2006-10-30 2015-02-03 Medtronic, Inc. Infusion catheter with composite tip
US20080103483A1 (en) * 2006-10-30 2008-05-01 Johnson Benjamin A Infusion catheter with composite tip
US7976530B2 (en) 2006-10-30 2011-07-12 Medtronic, Inc. Infusion catheter with composite tip
US11672553B2 (en) 2007-06-22 2023-06-13 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US8876774B2 (en) 2007-11-30 2014-11-04 Medtronic, Inc. Infusion catheter assembly with reduced backflow
US20090143764A1 (en) * 2007-11-30 2009-06-04 Medtronic, Inc. Infusion catheter assembly with reduced backflow
US8480626B2 (en) 2007-11-30 2013-07-09 Medtronic, Inc. Infusion catheter assembly with reduced backflow
US8603038B2 (en) 2008-01-22 2013-12-10 Medtronic, Inc. Burr hole anchors, systems, and methods
US20090187149A1 (en) * 2008-01-22 2009-07-23 Medtronic, Inc. Burr hole anchors, systems, and methods
US9427553B2 (en) 2010-04-28 2016-08-30 Medtronic, Inc. Body portal anchors and systems
US8738151B2 (en) 2010-04-28 2014-05-27 Medtronic, Inc. Body portal anchors and systems
US20120059285A1 (en) * 2010-08-27 2012-03-08 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US10888657B2 (en) * 2010-08-27 2021-01-12 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US10252032B2 (en) 2013-03-12 2019-04-09 Medtronic, Inc. Socketed portal anchors and methods of using same
US9302043B2 (en) 2013-03-12 2016-04-05 Medtronic, Inc. Socketed portal anchors and methods of using same
US9352125B2 (en) 2013-03-12 2016-05-31 Medtronic, Inc. Portal anchors incorporating strain relief cup and systems using same
US11013893B2 (en) 2013-03-12 2021-05-25 Medtronic, Inc. Socketed portal anchors and methods of using same
US9579494B2 (en) 2013-03-14 2017-02-28 Ekos Corporation Method and apparatus for drug delivery to a target site
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
US11740138B2 (en) 2015-06-10 2023-08-29 Ekos Corporation Ultrasound catheter
US10076387B2 (en) 2015-06-18 2018-09-18 Medtronic, Inc. Medical device implantation and positioning system
USD793549S1 (en) 2016-05-04 2017-08-01 DePuy Synthes Products, Inc. Catheter clip
US11298041B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
US11298043B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
US11497576B2 (en) 2017-07-17 2022-11-15 Voyager Therapeutics, Inc. Trajectory array guide system
US11925367B2 (en) 2018-12-20 2024-03-12 Ekos Corporation Power parameters for ultrasonic catheter
WO2021040818A1 (en) * 2019-08-28 2021-03-04 Infinivation Biomedical Llc Medical device anchor
US11554254B2 (en) 2019-08-28 2023-01-17 Infinivation Biomedical Llc Medical device anchor
WO2021195225A1 (en) * 2020-03-24 2021-09-30 The Penn State Research Foundation Surgical method, device, system and kit for the treatment of hydrocephalus
CN115040756A (en) * 2022-08-16 2022-09-13 生一科技(北京)有限公司 Catheter supporting device and lumen intervention system

Also Published As

Publication number Publication date
US7090661B2 (en) 2006-08-15
US20080004572A1 (en) 2008-01-03
US20050107744A1 (en) 2005-05-19
WO2003090820A1 (en) 2003-11-06
US7270650B2 (en) 2007-09-18
US20050101915A1 (en) 2005-05-12
US7517337B2 (en) 2009-04-14
AU2003263000A1 (en) 2003-11-10

Similar Documents

Publication Publication Date Title
US7090661B2 (en) Catheter anchor system and method
US11013893B2 (en) Socketed portal anchors and methods of using same
US9302043B2 (en) Socketed portal anchors and methods of using same
US9427553B2 (en) Body portal anchors and systems
US7452354B2 (en) Implantable pump connector for catheter attachment
US5192274A (en) Anchor pad for catheterization system
JP6151320B2 (en) Transdermal drug delivery device
JP5529541B2 (en) Nervous system device with percutaneous access device
US5120312A (en) Method and apparatus for catheterization
US9498248B2 (en) Retainer for immobilizing an implanted catheter during stylet retraction, and stylet holder for use with same
EP0843567B1 (en) Catheter anchoring system
US6682498B2 (en) Methods and systems for subcutaneous graft implantation
JP5587190B2 (en) Stereotaxic device
EP2070561A1 (en) Anchoring device for securing intracranial catheter or lead wire to a patient's skull
US9352125B2 (en) Portal anchors incorporating strain relief cup and systems using same
US5203770A (en) Method and apparatus for catheterization
US20150273202A1 (en) Neurosurgical device and method
US6468252B1 (en) Clamp for vascular access device
US20230011575A1 (en) Implantable drug delivery systems, assemblies, and methods
US20050119603A1 (en) Surgical implant for accessing cerebrospinal fluid and method of surgically inserting same

Legal Events

Date Code Title Description
AS Assignment

Owner name: MEDTRONIC, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MORRIS, MARY M.;FRION, DUANE GERALD;NOVOTNY, JEFF;AND OTHERS;REEL/FRAME:015553/0651;SIGNING DATES FROM 20041208 TO 20050104

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION

AS Assignment

Owner name: BAYER MATERIALSCIENCE LLC, PENNSYLVANIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DOBRANSKY, MICHAEL A.;YOURD, RAYMOND A.;WILSON, PATRICIA M.;REEL/FRAME:016741/0722;SIGNING DATES FROM 20050602 TO 20050607