US20040006301A1 - Magnetically guided myocardial treatment system - Google Patents
Magnetically guided myocardial treatment system Download PDFInfo
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- US20040006301A1 US20040006301A1 US10/437,267 US43726703A US2004006301A1 US 20040006301 A1 US20040006301 A1 US 20040006301A1 US 43726703 A US43726703 A US 43726703A US 2004006301 A1 US2004006301 A1 US 2004006301A1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0127—Magnetic means; Magnetic markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
- A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00392—Transmyocardial revascularisation
Definitions
- the present invention is related to the medical treatment of the myocardium and more specifically to devices for accessing the myocardium and to techniques for magnetically guided myocardial interventions.
- the first myocardial revascularization experiments were performed with a laser, which was used to perforate the heart from the “outside” of the heart.
- the laser energy was applied to the exterior wall of the ventricle and activated.
- the laser energy burns and chars a hole in the heart wall.
- the blood pool inside the heart prevents further injury to structures within the heart.
- the methods and devices of the invention are useful in a variety of settings.
- the invention is described in the context of myocardial revascularization which is one instance where the catheter is magnetically navigated to a site near a wall of the heart.
- Other examples of treatments include the repair of septal defects and heart biopsy. It is anticipated that some forms of cardiomyopathy may respond to therapies delivered with these tools as well. For this reason it must be understood that the devices and methods can be used in a variety of contexts within the body.
- an RF heated tip is preferred since it can be used both to cut and to coagulate tissues depending on the delivered energy level. This feature is shared with laser-heated tips and thermal catheter technologies but RF devices have a greater history of use for coagulation.
- the proposed methods of the invention can be used to move the catheter device both along and across the muscle planes within the heart tissue so that a complex should pathway or “tunnel” can be created.
- This structured shape can be used to retain “implant” materials such as growth factor. Growth factor or other drugs may be embedded in or on absorbable material.
- the lesion can be in the form of a “blind” hole and the drug can be left behind in the wound and retained magnetically inside the tissues.
- FIG. 1 is a schematic of a heart showing two surgical approaches
- FIG. 2 is a representation of a step in the method
- FIG. 3 is a representation of a step in the method
- FIG. 4 is a representation of a step in the method
- FIG. 5 is a representation of a step in the method
- FIG. 7 is a representation of a step in the method
- FIG. 8 is a schematic of an exemplary thermal catheter
- FIG. 9 is a schematic of a mechanical revascularization catheter
- FIG. 10 is schematic of a RF revascularization catheter
- FIG. 11 is a representation of a serpentine path through the heart tissue possible with the methods and apparatus of this invention.
- FIG. 12 is perspective view of one embodiment of an apparatus useful in the methods of this invention.
- FIG. 13 is a side elevation view of another embodiment of an apparatus useful in the methods of this invention.
- FIG. 1 shows a schematic heart 10 located within the patient interacting with a magnetic surgery system or MSS 12 .
- MSS 12 Two different surgical approaches are shown in the figure represented by catheter 16 and catheter 22 .
- the MSS system 12 includes a magnet system 14 , which can generate controlled fields and gradients within the patient.
- the MSS 12 may also optionally include a localization system 17 , which can be used to find the location and direction of the catheter tip within the body.
- the MSS 12 may also optionally include an imaging system 15 , which can be used to display the real time location of the catheter with respect to the tissues.
- the imaging system 15 can also be used to collect preoperative images to guide the procedure.
- a companion workstation 18 is interfaced with these systems and controls them through the workstation 19 .
- the energy source for the revascularization catheter is under the control of the MSS as well so that the therapy is integrated through the workstation. In general, the advancement of the catheter can be performed directly by the physician or the process may be automated through the workstation. For these reasons the invention contemplates both fully manual and fully automatic procedures mediated by the MSS.
- Catheter 16 is depicted in a ventricle for a therapeutic intervention.
- This catheter shows a percutaneous transluminal access of the ventricle.
- Catheter 22 is shown in contact with the ventricle through an incision in the chest.
- This catheter shows a pericardial access to the epicardial surface of the heart 10 .
- Catheters may also approach the heart through a site in the coronary tree. Although three different approaches are shown or described, the remainder of the description is disclosed in the context of the preferred transluminal approach for simplicity and clarity of disclosure. It should be recognized that the devices and procedures might be used in the other approaches as well.
- FIG. 2 shows a catheter 16 in contact with the endocardial surface 11 of the heart.
- the distal tip 24 may include a magnetic or magnitizable material that interacts with the MSS field 26 .
- One distinct advantage of this approach is that the applied field creates a force that holds the tip 24 in contact with the moving myocardial wall 28 .
- FIG. 3 shows the tip 24 turning under the influence of the MSS.
- a primary entrance axis is defined and shown in the figure as axis 36 while the instantaneous direction of travel is shown as path 38 . It is a property of the device 16 that can track in the tissue and turn from an entry path through approximately 90 degrees within the distance of the heart wall.
- FIG. 4 is an example of the use of the system to treat an infracted region 17 of the heart by encircling it with an ablation path within the wall 28 of the heart.
- the MSS system is used to define the circular path indicated in the figure as path 19 .
- FIG. 5 shows the catheter 16 being used to define a very complex path within the heart wall 28 .
- the MSS defines the arcuate path 21 and the magnetic tip 24 of the catheter 16 follows the path.
- the ablation energy source is sufficient to tunnel in the tissue.
- Ablation wounds for this nature may be used to treat ‘hibernating tissue’ with drugs and the like.
- FIG. 6 shows a guided intervention with the myocardial tissues.
- the MSS 12 can be used to define a path for the tip 24 of the catheter 16 .
- a simple straight through path is depicted as path 38 this path takes the catheter 16 tip 24 completely through the block of tissue 11 .
- the curved path is shown as path 36 which turns within the tissue so that the tip 24 is retained in the myocardium.
- the tip 24 is following the curved path 36 .
- the tip enters the tissue at an approximately orthogonal angle and remains within the myocardial tissues and creates a blind “wormhole” lesion or path.
- a lumen 40 in the catheter body 42 can be used to deliver a drug such as growth factor to the site of the injury.
- FIG. 6 shows a set of wormhole tracks, which share a common entry point 42 .
- the catheter body may be retracted along the track and repositioned with the MSS to create a complex series of lesions that share the common entry point forming a “star” shaped system of tunnels.
- the power level at the tip 24 can be reduced and the tip can “cauterize” or seal the opening entry point 42 .
- FIG. 7 shows a preferred therapy where a RF heated catheter is used to create a “wormhole” lesion under the control of the field 26 .
- a RF heated catheter is used to create a “wormhole” lesion under the control of the field 26 .
- drug coated magnetic particles typified by particle 60 .
- the distal tip 52 cauterized the tissue on the exit path coagulating tissue shown as plug 63 .
- FIG. 8 shows an illustrative but preferred catheter 16 .
- the preferred tunneling energy is a heated tip 24 which may accomplish with either radio frequency (RF) or laser energy through an optical fiber 33 from the energy source 21 .
- RF radio frequency
- Localization coils 30 or the like in the catheter 31 may be used with the MSS to reveal the real time location of the catheter.
- Real time biplane fluoroscopy can also be used to show the physician the location of the device against the wall.
- the coils or other structures may be included to increase the radiopacity of the catheter tip.
- FIG. 9 shows a mechanical catheter with a retractable needle 51 , which may be manipulated through the proximal wire 56 .
- the needle can be used to pierce the heart wall.
- the catheter body 57 includes an optional lumen 40 , which may be used to deliver a drug during the therapy.
- FIG. 10 is an RF heated bipolar catheter using a distal electrode tip 52 with a proximal indifferent electrode 53 to supply heat to the tissues.
- An optional lumen 40 is shown for the delivery of a drug.
- One advantage of the RF catheter is the ability to lower the energy delivered to coagulate tissues.
- FIG. 11 is a representation of a serpentine path 100 through the heart tissue 102 possible with the methods and apparatus of the various embodiments of this invention.
- the serpentine path 100 has a generally “S” shape, and preferably contain at least two bends of greater than 90°.
- the complicated path 100 helps retain substances delivered therein, but was difficult if not impossible to form with the apparatus and methods of the prior art.
- a device useful in the methods of this invention is indicated generally as 150 in FIG. 12.
- the device 150 has a proximal end (not shown) a distal end 154 , and a sidewall 156 extending therebetween defining a lumen 158 preferably extending the length of the device.
- An electrode 160 with a dome shape, is disposed at the distal end, and is provided with RF energy via lead 162 .
- the element 164 is either a permanent magnetic material such as a neodymium-iron-boron alloy, or a permeable magnetic material.
- the material is selected, and the element is sized and shaped so that in an applied magnetic field, such as that from a MNS as discussed above, a magnetic moment is created orienting the distal end of the device in a selected direction.
- a tube 166 extends through the lumen, through a passage in the magnet element 164 , and opens to a passage in the electrode 160 , so that materials can be delivered into the paths created by the distal end of the device 150 .
- the distal end of the device is navigated to the heart, and pressed against the heart wall.
- the RF energy is applied to the electrode 160 to form a hole in the heart tissue, by magnetically orienting the device 150 (by changing the external field direction) and advancing the device (either manually or with a motoized advancer) tunnels can be formed.
- the paths formed by the device can take on complex shapes, which allowed for wider dispersal of agents, and improved retention of those agents.
- the present invention permits the formation of serpentine paths, such as path 100 in FIG. 11.
- the device 200 has a proximal end (not shown) a distal end 204 , and a sidewall 206 extending therebetween defining a lumen 208 preferably extending the length of the device.
- the distal end 204 of the device 200 preferably has a generally rounded or dome-shaped configuration.
- the element 214 is a set of three mutually perpendicular coils 216 , 218 , and 220 , that can be selectively energized to create a magnetic moment, preferably in any direction.
- Pairs of lead wires can independently power each of the coils.
- the distal end 204 of the device can be oriented in any direction by the controlled application of currents to the coils 216 , 218 , and 220 .
- a magnetic field an be applied with a MNS, but the magnetic field could also be provided by a MR imaging system.
- An MR imaging system could provide a particularly strong magnetic field that is useful in navigating.
- the navigation of a medical device in an operating region with the aid of an externally applied magnetic field, such as that provided by an MRI device, by using a controllable variable magnetic moment in the device tip has been proposed, and is in fact the subject of Kuhn, U.S. Pat. No. 6,216,026, Arenson, U.S. Pat. No. 6,304,769, and Hastings et al., U.S. Pat. No. 6,401,723, the disclosures of which are incorporated herein by reference.
- the MR imaging system also provides images of the tissues, so that the distal end 204 of the device 200 can be properly controlled to formed the desired complex paths.
- imaging systems can be used including OCT, OCR, or ultrasound.
- some localization system can be used to further fix the position of the distal end of the device.
- the coils 216 , 218 , and 220 can be used as part of a magnetic localization to fix the position and/or orientation, of the element 214 , and thus of the distal end of the device.
- An optical fiber 222 extends the length of the device 200 , and is connected at its proximal end to a laser that provides energy for ablating tissue at the distal end of the optical fiber.
- a tube 224 extends through the lumen, and opens to a passage in the distal end 204 of the device 200 , so that materials can be delivered into the paths created by the distal end of the device.
- the distal end of the device is navigated to the heart, and pressed against the heart wall.
- the laser energy is applied to the optical fiber 222 to form a hole in the heart tissue, by magnetically orienting the device 200 (by changing the current in the coils 216 , 218 , and 220 and/or changing the external field direction) and advancing the device (either manually or with a motorized advancer) tunnels can be formed.
- the paths formed by the device can take on complex shapes, which allowed for wider dispersal of agents, and improved retention of those agents.
- the present invention permits the formation of serpentine paths, such as path 100 in FIG. 11.
- the methods can be used to form passageways in the heart tissue, and or to deliver substances to the heart tissue via the passageways.
- substances include stem cells (and particularly Autologous Cultured Stem Cells), gene therapy, VEGF (vascular endothelial growth factor), myoblasts, drugs and other materials and substances.
- stem cells and particularly Autologous Cultured Stem Cells
- VEGF vascular endothelial growth factor
- myoblasts drugs and other materials and substances.
Abstract
A magnetically topped catheter is used to tunnel into the myocardium for cardiac treatment.
Description
- This application is a continuation-in-part of U.S. patent application Ser. No. 09/398,686, filed Sep. 20, 1999, now U.S. Pat. No. 6,562,019, issued May 12, 2003, the disclosure of which is incorporated herein by reference.
- The present invention is related to the medical treatment of the myocardium and more specifically to devices for accessing the myocardium and to techniques for magnetically guided myocardial interventions.
- Various diseases exist that require precise access to the heart muscle. Current treatment modalities have been limited by the ability to direct and hold treatment devices in the proper location in a beating heart. Consequently, major open surgical interventions are common where a minimally invasive approach would be preferable. One such procedure is myocardial revascularization and the inventions are described in that context.
- For example, patients who exhibit ischemic heart disease and who experience angina can be treated by perforating the wall of the ventricle. It is not entirely understood why this form of injury improves the cardiac performance of the patient. Some evidence suggest that the healing response to the injury causes new blood vessels to form and increases the size of existing blood vessels. The additional blood flow relieves the symptom angina.
- The first myocardial revascularization experiments were performed with a laser, which was used to perforate the heart from the “outside” of the heart. In general, the laser energy was applied to the exterior wall of the ventricle and activated. In use, the laser energy burns and chars a hole in the heart wall. The blood pool inside the heart prevents further injury to structures within the heart.
- More recently, it has been proposed to revascularize the heart wall through a percutaneous transluminal approach. See for example Nita, U.S. Pat. No. 5,927,203, incorporated herein by reference. This technique can be used to place a catheter against the endocardial surface of the heart. However, the heart wall is in constant motion and this relative motion renders creation of the lesion problematic.
- In general, both improved devices and techniques are needed to advance this therapy.
- The methods and devices of the invention are useful in a variety of settings. For purposes of illustration, the invention is described in the context of myocardial revascularization which is one instance where the catheter is magnetically navigated to a site near a wall of the heart. Other examples of treatments include the repair of septal defects and heart biopsy. It is anticipated that some forms of cardiomyopathy may respond to therapies delivered with these tools as well. For this reason it must be understood that the devices and methods can be used in a variety of contexts within the body.
- A magnetically navigable and controllable catheter device is deployed at the heart wall and this device tunnels into the myocardium. Any of a variety of canalization techniques can be used to tunnel into the heart wall causing mechanical disruption of the tissues, including mechanical needles and RF energy sources as well as direct laser and heated tips. In a preferred embodiment, the catheter device guided by externally applied magnetic fields that are created by a magnetic surgery system (MSS). The MSS applies magnetic fields and gradients from outside the body to manipulate and direct medical devices within the body. The catheter devices of some embodiments of the present invention include magnetic elements that respond to the MSS field or gradient. In general, the physician interacts with a workstation that is associated with the MSS. The physician may define paths and monitor the progress of a procedure. Fully automatic and fully manual methods are operable with the invention.
- Although several energy sources are disclosed that can be delivered by the catheter through its distal tip, an RF heated tip is preferred since it can be used both to cut and to coagulate tissues depending on the delivered energy level. This feature is shared with laser-heated tips and thermal catheter technologies but RF devices have a greater history of use for coagulation.
- The proposed methods of the invention can be used to move the catheter device both along and across the muscle planes within the heart tissue so that a complex should pathway or “tunnel” can be created. This structured shape can be used to retain “implant” materials such as growth factor. Growth factor or other drugs may be embedded in or on absorbable material. In some instances it may be desirable to combine the drug with a magnetic particle sot that the gradient and fields can be used to position and retain the drug in the tissue. For example, the lesion can be in the form of a “blind” hole and the drug can be left behind in the wound and retained magnetically inside the tissues.
- For purposes of this discussion, the term “ablation” or “lesion” should be considered to include thermally damaged tissues, eroded and charred tissue by other processes that destroy or remove tissue. Typical devices to carry out this “injury” include mechanical, RF, electrical, thermal, optical, and ultrasonic means. Throughout the description the wound is referred to as a tunnel in recognition of its shape.
- Throughout the various figures of the drawing identical reference numerals are used to indicate identical or equivalent structure, wherein:
- FIG. 1 is a schematic of a heart showing two surgical approaches;
- FIG. 2 is a representation of a step in the method;
- FIG. 3 is a representation of a step in the method;
- FIG. 4 is a representation of a step in the method;
- FIG. 5 is a representation of a step in the method;
- FIG. 6 is a representation of a step in the method;
- FIG. 7is a representation of a step in the method;
- FIG. 8 is a schematic of an exemplary thermal catheter;
- FIG. 9 is a schematic of a mechanical revascularization catheter;
- FIG. 10 is schematic of a RF revascularization catheter;
- FIG. 11 is a representation of a serpentine path through the heart tissue possible with the methods and apparatus of this invention;
- FIG. 12 is perspective view of one embodiment of an apparatus useful in the methods of this invention;
- FIG. 13 is a side elevation view of another embodiment of an apparatus useful in the methods of this invention.
- Corresponding reference numerals indicate corresponding parts throughout the several views of the drawings.
- FIG. 1 shows a
schematic heart 10 located within the patient interacting with a magnetic surgery system orMSS 12. Two different surgical approaches are shown in the figure represented bycatheter 16 andcatheter 22. - The
MSS system 12 includes amagnet system 14, which can generate controlled fields and gradients within the patient. TheMSS 12 may also optionally include alocalization system 17, which can be used to find the location and direction of the catheter tip within the body. TheMSS 12 may also optionally include animaging system 15, which can be used to display the real time location of the catheter with respect to the tissues. Theimaging system 15 can also be used to collect preoperative images to guide the procedure. A companion workstation 18 is interfaced with these systems and controls them through theworkstation 19. It should be noted that the energy source for the revascularization catheter is under the control of the MSS as well so that the therapy is integrated through the workstation. In general, the advancement of the catheter can be performed directly by the physician or the process may be automated through the workstation. For these reasons the invention contemplates both fully manual and fully automatic procedures mediated by the MSS. -
Catheter 16 is depicted in a ventricle for a therapeutic intervention. This catheter shows a percutaneous transluminal access of the ventricle.Catheter 22 is shown in contact with the ventricle through an incision in the chest. This catheter shows a pericardial access to the epicardial surface of theheart 10. Catheters may also approach the heart through a site in the coronary tree. Although three different approaches are shown or described, the remainder of the description is disclosed in the context of the preferred transluminal approach for simplicity and clarity of disclosure. It should be recognized that the devices and procedures might be used in the other approaches as well. - FIG. 2 shows a
catheter 16 in contact with theendocardial surface 11 of the heart. Thedistal tip 24 may include a magnetic or magnitizable material that interacts with theMSS field 26. One distinct advantage of this approach is that the applied field creates a force that holds thetip 24 in contact with the movingmyocardial wall 28. Once an appropriate starting position has been established thetip 24 is activated through theworkstation 19 and the catheter enters themyocardial wall 11 seen best in FIG. 3. - FIG. 3 shows the
tip 24 turning under the influence of the MSS. A primary entrance axis is defined and shown in the figure asaxis 36 while the instantaneous direction of travel is shown aspath 38. It is a property of thedevice 16 that can track in the tissue and turn from an entry path through approximately 90 degrees within the distance of the heart wall. - FIG. 4 is an example of the use of the system to treat an
infracted region 17 of the heart by encircling it with an ablation path within thewall 28 of the heart. In use, the MSS system is used to define the circular path indicated in the figure aspath 19. - FIG. 5 shows the
catheter 16 being used to define a very complex path within theheart wall 28. The MSS defines thearcuate path 21 and themagnetic tip 24 of thecatheter 16 follows the path. In use, the ablation energy source is sufficient to tunnel in the tissue. Ablation wounds for this nature may be used to treat ‘hibernating tissue’ with drugs and the like. - FIG. 6 shows a guided intervention with the myocardial tissues. The
MSS 12 can be used to define a path for thetip 24 of thecatheter 16. A simple straight through path is depicted aspath 38 this path takes thecatheter 16tip 24 completely through the block oftissue 11. The curved path is shown aspath 36 which turns within the tissue so that thetip 24 is retained in the myocardium. In the illustration thetip 24 is following thecurved path 36. In this example the tip, enters the tissue at an approximately orthogonal angle and remains within the myocardial tissues and creates a blind “wormhole” lesion or path. Alumen 40 in thecatheter body 42 can be used to deliver a drug such as growth factor to the site of the injury. Other candidate drugs contemplated within the scope of the disclosure include VEGF vascular endothelial growth factor aFGF acidic fibroblast growth factor. It is believed that the uptake of the drug will be effective and result in the rapid development of new vessels. FIG. 6 shows a set of wormhole tracks, which share acommon entry point 42. In operation, the catheter body may be retracted along the track and repositioned with the MSS to create a complex series of lesions that share the common entry point forming a “star” shaped system of tunnels. Upon retraction out of the tissues the power level at thetip 24 can be reduced and the tip can “cauterize” or seal theopening entry point 42. - FIG. 7 shows a preferred therapy where a RF heated catheter is used to create a “wormhole” lesion under the control of the
field 26. During withdrawal of the catheter deposit drug coated magnetic particles typified byparticle 60. Thedistal tip 52 cauterized the tissue on the exit path coagulating tissue shown asplug 63. - FIG. 8 shows an illustrative but
preferred catheter 16. The preferred tunneling energy is aheated tip 24 which may accomplish with either radio frequency (RF) or laser energy through anoptical fiber 33 from theenergy source 21. - Localization coils30 or the like in the
catheter 31 may be used with the MSS to reveal the real time location of the catheter. Real time biplane fluoroscopy can also be used to show the physician the location of the device against the wall. The coils or other structures may be included to increase the radiopacity of the catheter tip. - FIG. 9 shows a mechanical catheter with a
retractable needle 51, which may be manipulated through theproximal wire 56. In use, the needle can be used to pierce the heart wall. Thecatheter body 57 includes anoptional lumen 40, which may be used to deliver a drug during the therapy. - FIG. 10 is an RF heated bipolar catheter using a
distal electrode tip 52 with a proximalindifferent electrode 53 to supply heat to the tissues. Anoptional lumen 40 is shown for the delivery of a drug. One advantage of the RF catheter is the ability to lower the energy delivered to coagulate tissues. - FIG. 11 is a representation of a
serpentine path 100 through theheart tissue 102 possible with the methods and apparatus of the various embodiments of this invention. As shown in FIG. 11, theserpentine path 100 has a generally “S” shape, and preferably contain at least two bends of greater than 90°. Thecomplicated path 100 helps retain substances delivered therein, but was difficult if not impossible to form with the apparatus and methods of the prior art. - A device useful in the methods of this invention is indicated generally as150 in FIG. 12. The
device 150 has a proximal end (not shown) adistal end 154, and asidewall 156 extending therebetween defining alumen 158 preferably extending the length of the device. An electrode 160, with a dome shape, is disposed at the distal end, and is provided with RF energy vialead 162. There as preferably a magneticallyresponsive element 164 in the distal end portion of thedevice 150. Theelement 164 is either a permanent magnetic material such as a neodymium-iron-boron alloy, or a permeable magnetic material. The material is selected, and the element is sized and shaped so that in an applied magnetic field, such as that from a MNS as discussed above, a magnetic moment is created orienting the distal end of the device in a selected direction. Atube 166 extends through the lumen, through a passage in themagnet element 164, and opens to a passage in the electrode 160, so that materials can be delivered into the paths created by the distal end of thedevice 150. - In operation the distal end of the device is navigated to the heart, and pressed against the heart wall. The RF energy is applied to the electrode160 to form a hole in the heart tissue, by magnetically orienting the device 150 (by changing the external field direction) and advancing the device (either manually or with a motoized advancer) tunnels can be formed. However, because of the unique control permitted with magnetic navigation together with the very small size and extreme flexibility of the device, the paths formed by the device can take on complex shapes, which allowed for wider dispersal of agents, and improved retention of those agents. In particular the present invention permits the formation of serpentine paths, such as
path 100 in FIG. 11. - Another device useful in the methods of this invention is indicated generally as200 in FIG. 13. The device 200 has a proximal end (not shown) a
distal end 204, and asidewall 206 extending therebetween defining a lumen 208 preferably extending the length of the device. Thedistal end 204 of the device 200 preferably has a generally rounded or dome-shaped configuration. There as preferably a magneticallyresponsive element 214 in the distal end portion of the device 200. In this preferred embodiment, theelement 214 is a set of three mutuallyperpendicular coils distal end 204 of the device can be oriented in any direction by the controlled application of currents to thecoils - The MR imaging system also provides images of the tissues, so that the
distal end 204 of the device 200 can be properly controlled to formed the desired complex paths. Of course, other imaging systems can be used including OCT, OCR, or ultrasound. In stead of, but more preferably in addition to imaging, some localization system can be used to further fix the position of the distal end of the device. To this end thecoils element 214, and thus of the distal end of the device. - An
optical fiber 222 extends the length of the device 200, and is connected at its proximal end to a laser that provides energy for ablating tissue at the distal end of the optical fiber. - A
tube 224 extends through the lumen, and opens to a passage in thedistal end 204 of the device 200, so that materials can be delivered into the paths created by the distal end of the device. - In operation the distal end of the device is navigated to the heart, and pressed against the heart wall. The laser energy is applied to the
optical fiber 222 to form a hole in the heart tissue, by magnetically orienting the device 200 (by changing the current in thecoils path 100 in FIG. 11. - The methods can be used to form passageways in the heart tissue, and or to deliver substances to the heart tissue via the passageways. These substances include stem cells (and particularly Autologous Cultured Stem Cells), gene therapy, VEGF (vascular endothelial growth factor), myoblasts, drugs and other materials and substances. For example, as disclosed in Law, The Regenerative Heart, in Business Briefing:Pharmatech 2002 incorporated herein by references, various treatments for the regeneration of heart tissue as discussed such as va
Claims (11)
1. A method for myocardial treatment comprising the steps of:
navigating a catheter to a treatment site;
displacing the catheter into the tissue at the treatment site
directing the tip of the catheter with magnetic fields applied from outside the body;
advancing the tip through tissue causing mechanical disruption of tissue forming a tunnel in the tissue at the treatment site.
2. The method of claim 1 wherein the catheter delivers ablation energy during the advancing step.
3. The method of claim 1 including the further step of:
stopping the advancing prior to the catheter tip exiting the tissue, thereby creating a blind hole tunnel in the tissue.
4. The method of claim 1 wherein:
the directing step causes the tip to orient through an angle of approximately 90 degrees as measured from the entry angle between the tissue plane and the catheter body.
5. The method of claim 3 further comprising:
repeating the steps of claim 3 sequentially while turning the catheter at the entry point, thereby forming a star shaped tunnel in the tissue.
6. The method of claim 1 further including the steps of:
injecting a drug through the catheter into the lesion;
withdrawing the catheter from the tunnel.
7. The method of claim 6 further including the step:
sealing the tunnel upon exit of the catheter from the tunnel whereby drug left in the wound is sealed in the tissue.
8. A catheter comprising:
a catheter body having a proximal end and a distal end;
a tunneling structure located at the distal end of the catheter body;
a magnetic element located proximate the distal tip of said catheter body; for guiding the catheter tip in response to external magnetic fields and gradients.
9. The catheter of claim 8 further comprising:
a lumen extending to the location proximate the distal tip for the delivery of drug to the site of the catheter.
10. A method of treating the heart comprising the steps of:
navigating a catheter to the myocardium;
entering the myocardium assisted by the application of externally generated magnetic fields and gradients to create a treatment site;
delivering a magnetically bound drug to the treatment site;
withdrawing the catheter while retaining the drug of the site with a magnetic field or gradient.
11. A method of treating the heart comprising:
navigating a catheter having a magnetic tip to the myocardium using externally applied magnetic fields or gradients to direct the tip;
advancing the catheter into the myocardium at a singular treatment site;
injecting a drug through a lumen in the catheter into the myocardium at the treatment site;
withdrawing the catheter from the treatment site.
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US10/437,267 US20040006301A1 (en) | 1999-09-20 | 2003-05-13 | Magnetically guided myocardial treatment system |
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US09/398,686 US6562019B1 (en) | 1999-09-20 | 1999-09-20 | Method of utilizing a magnetically guided myocardial treatment system |
US10/437,267 US20040006301A1 (en) | 1999-09-20 | 2003-05-13 | Magnetically guided myocardial treatment system |
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US09/398,686 Continuation-In-Part US6562019B1 (en) | 1999-09-20 | 1999-09-20 | Method of utilizing a magnetically guided myocardial treatment system |
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US10/437,267 Abandoned US20040006301A1 (en) | 1999-09-20 | 2003-05-13 | Magnetically guided myocardial treatment system |
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Cited By (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020032478A1 (en) * | 2000-08-07 | 2002-03-14 | Percardia, Inc. | Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel |
US20020045928A1 (en) * | 2000-05-04 | 2002-04-18 | Percardia, Inc. | Methods and devices for delivering a ventricular stent |
US20020099404A1 (en) * | 2001-01-25 | 2002-07-25 | Mowry David H. | Intravascular ventriculocoronary artery bypass delivery modalities |
US20020177789A1 (en) * | 2001-05-06 | 2002-11-28 | Ferry Steven J. | System and methods for advancing a catheter |
US20030158509A1 (en) * | 2002-02-13 | 2003-08-21 | Tweden Katherine S. | Cardiac implant and methods |
US20030220661A1 (en) * | 2002-05-21 | 2003-11-27 | Heartstent Corporation | Transmyocardial implant delivery system |
US20040106931A1 (en) * | 1999-08-04 | 2004-06-03 | Percardia, Inc. | Left ventricular conduits and methods for delivery |
US20040169316A1 (en) * | 2002-03-28 | 2004-09-02 | Siliconix Taiwan Ltd. | Encapsulation method and leadframe for leadless semiconductor packages |
US20040210190A1 (en) * | 2001-08-16 | 2004-10-21 | Percardia, Inc. | Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts |
US20050113812A1 (en) * | 2003-09-16 | 2005-05-26 | Viswanathan Raju R. | User interface for remote control of medical devices |
US20050154389A1 (en) * | 2003-12-16 | 2005-07-14 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US20060036163A1 (en) * | 2004-07-19 | 2006-02-16 | Viswanathan Raju R | Method of, and apparatus for, controlling medical navigation systems |
US20060052656A1 (en) * | 2004-09-09 | 2006-03-09 | The Regents Of The University Of California | Implantable devices using magnetic guidance |
US20060144407A1 (en) * | 2004-07-20 | 2006-07-06 | Anthony Aliberto | Magnetic navigation manipulation apparatus |
US20060144408A1 (en) * | 2004-07-23 | 2006-07-06 | Ferry Steven J | Micro-catheter device and method of using same |
US20060269108A1 (en) * | 2005-02-07 | 2006-11-30 | Viswanathan Raju R | Registration of three dimensional image data to 2D-image-derived data |
US20060270915A1 (en) * | 2005-01-11 | 2006-11-30 | Ritter Rogers C | Navigation using sensed physiological data as feedback |
US20060276867A1 (en) * | 2005-06-02 | 2006-12-07 | Viswanathan Raju R | Methods and devices for mapping the ventricle for pacing lead placement and therapy delivery |
US20060278246A1 (en) * | 2003-05-21 | 2006-12-14 | Michael Eng | Electrophysiology catheter |
US20060281990A1 (en) * | 2005-05-06 | 2006-12-14 | Viswanathan Raju R | User interfaces and navigation methods for vascular navigation |
US20060281989A1 (en) * | 2005-05-06 | 2006-12-14 | Viswanathan Raju R | Voice controlled user interface for remote navigation systems |
US20070016131A1 (en) * | 2005-07-12 | 2007-01-18 | Munger Gareth T | Flexible magnets for navigable medical devices |
US20070021731A1 (en) * | 1997-11-12 | 2007-01-25 | Garibaldi Jeffrey M | Method of and apparatus for navigating medical devices in body lumens |
US20070021742A1 (en) * | 2005-07-18 | 2007-01-25 | Viswanathan Raju R | Estimation of contact force by a medical device |
US20070019330A1 (en) * | 2005-07-12 | 2007-01-25 | Charles Wolfersberger | Apparatus for pivotally orienting a projection device |
US20070021744A1 (en) * | 2005-07-07 | 2007-01-25 | Creighton Francis M Iv | Apparatus and method for performing ablation with imaging feedback |
US20070030958A1 (en) * | 2005-07-15 | 2007-02-08 | Munger Gareth T | Magnetically shielded x-ray tube |
US20070038410A1 (en) * | 2005-08-10 | 2007-02-15 | Ilker Tunay | Method and apparatus for dynamic magnetic field control using multiple magnets |
US20070038064A1 (en) * | 2005-07-08 | 2007-02-15 | Creighton Francis M Iv | Magnetic navigation and imaging system |
US20070038065A1 (en) * | 2005-07-07 | 2007-02-15 | Creighton Francis M Iv | Operation of a remote medical navigation system using ultrasound image |
US20070038074A1 (en) * | 1998-02-09 | 2007-02-15 | Ritter Rogers C | Method and device for locating magnetic implant source field |
US20070043455A1 (en) * | 2005-07-26 | 2007-02-22 | Viswanathan Raju R | Apparatus and methods for automated sequential movement control for operation of a remote navigation system |
US20070055124A1 (en) * | 2005-09-01 | 2007-03-08 | Viswanathan Raju R | Method and system for optimizing left-heart lead placement |
US20070060962A1 (en) * | 2005-07-26 | 2007-03-15 | Carlo Pappone | Apparatus and methods for cardiac resynchronization therapy and cardiac contractility modulation |
US20070060829A1 (en) * | 2005-07-21 | 2007-03-15 | Carlo Pappone | Method of finding the source of and treating cardiac arrhythmias |
US20070060966A1 (en) * | 2005-07-11 | 2007-03-15 | Carlo Pappone | Method of treating cardiac arrhythmias |
US20070062547A1 (en) * | 2005-07-21 | 2007-03-22 | Carlo Pappone | Systems for and methods of tissue ablation |
US20070062546A1 (en) * | 2005-06-02 | 2007-03-22 | Viswanathan Raju R | Electrophysiology catheter and system for gentle and firm wall contact |
US20070088197A1 (en) * | 2000-02-16 | 2007-04-19 | Sterotaxis, Inc. | Magnetic medical devices with changeable magnetic moments and method of navigating magnetic medical devices with changeable magnetic moments |
US20070088077A1 (en) * | 1991-02-26 | 2007-04-19 | Plasse Terry F | Appetite stimulation and reduction of weight loss in patients suffering from symptomatic hiv infection |
US20070149946A1 (en) * | 2005-12-07 | 2007-06-28 | Viswanathan Raju R | Advancer system for coaxial medical devices |
US20070146106A1 (en) * | 1999-10-04 | 2007-06-28 | Creighton Francis M Iv | Rotating and pivoting magnet for magnetic navigation |
US20070161882A1 (en) * | 2006-01-06 | 2007-07-12 | Carlo Pappone | Electrophysiology catheter and system for gentle and firm wall contact |
US20070167720A1 (en) * | 2005-12-06 | 2007-07-19 | Viswanathan Raju R | Smart card control of medical devices |
US20070197899A1 (en) * | 2006-01-17 | 2007-08-23 | Ritter Rogers C | Apparatus and method for magnetic navigation using boost magnets |
US20070197906A1 (en) * | 2006-01-24 | 2007-08-23 | Ritter Rogers C | Magnetic field shape-adjustable medical device and method of using the same |
US20070250041A1 (en) * | 2006-04-19 | 2007-10-25 | Werp Peter R | Extendable Interventional Medical Devices |
US20070287909A1 (en) * | 1998-08-07 | 2007-12-13 | Stereotaxis, Inc. | Method and apparatus for magnetically controlling catheters in body lumens and cavities |
US20080006280A1 (en) * | 2004-07-20 | 2008-01-10 | Anthony Aliberto | Magnetic navigation maneuvering sheath |
US20080015670A1 (en) * | 2006-01-17 | 2008-01-17 | Carlo Pappone | Methods and devices for cardiac ablation |
US20080015427A1 (en) * | 2006-06-30 | 2008-01-17 | Nathan Kastelein | System and network for remote medical procedures |
US20080016677A1 (en) * | 2002-01-23 | 2008-01-24 | Stereotaxis, Inc. | Rotating and pivoting magnet for magnetic navigation |
US20080039830A1 (en) * | 2006-08-14 | 2008-02-14 | Munger Gareth T | Method and Apparatus for Ablative Recanalization of Blocked Vasculature |
US20080045892A1 (en) * | 2001-05-06 | 2008-02-21 | Ferry Steven J | System and Methods for Advancing a Catheter |
US20080047568A1 (en) * | 1999-10-04 | 2008-02-28 | Ritter Rogers C | Method for Safely and Efficiently Navigating Magnetic Devices in the Body |
US20080055239A1 (en) * | 2006-09-06 | 2008-03-06 | Garibaldi Jeffrey M | Global Input Device for Multiple Computer-Controlled Medical Systems |
US20080058609A1 (en) * | 2006-09-06 | 2008-03-06 | Stereotaxis, Inc. | Workflow driven method of performing multi-step medical procedures |
US20080059598A1 (en) * | 2006-09-06 | 2008-03-06 | Garibaldi Jeffrey M | Coordinated Control for Multiple Computer-Controlled Medical Systems |
US20080065061A1 (en) * | 2006-09-08 | 2008-03-13 | Viswanathan Raju R | Impedance-Based Cardiac Therapy Planning Method with a Remote Surgical Navigation System |
US20080064969A1 (en) * | 2006-09-11 | 2008-03-13 | Nathan Kastelein | Automated Mapping of Anatomical Features of Heart Chambers |
US20080077007A1 (en) * | 2002-06-28 | 2008-03-27 | Hastings Roger N | Method of Navigating Medical Devices in the Presence of Radiopaque Material |
US20080097200A1 (en) * | 2006-10-20 | 2008-04-24 | Blume Walter M | Location and Display of Occluded Portions of Vessels on 3-D Angiographic Images |
US20080132910A1 (en) * | 2006-11-07 | 2008-06-05 | Carlo Pappone | Control for a Remote Navigation System |
US20080200913A1 (en) * | 2007-02-07 | 2008-08-21 | Viswanathan Raju R | Single Catheter Navigation for Diagnosis and Treatment of Arrhythmias |
US20080208912A1 (en) * | 2007-02-26 | 2008-08-28 | Garibaldi Jeffrey M | System and method for providing contextually relevant medical information |
US20080228068A1 (en) * | 2007-03-13 | 2008-09-18 | Viswanathan Raju R | Automated Surgical Navigation with Electro-Anatomical and Pre-Operative Image Data |
US20080228065A1 (en) * | 2007-03-13 | 2008-09-18 | Viswanathan Raju R | System and Method for Registration of Localization and Imaging Systems for Navigational Control of Medical Devices |
US20080287909A1 (en) * | 2007-05-17 | 2008-11-20 | Viswanathan Raju R | Method and apparatus for intra-chamber needle injection treatment |
US20080294232A1 (en) * | 2007-05-22 | 2008-11-27 | Viswanathan Raju R | Magnetic cell delivery |
US20080292901A1 (en) * | 2007-05-24 | 2008-11-27 | Hon Hai Precision Industry Co., Ltd. | Magnesium alloy and thin workpiece made of the same |
US20080312673A1 (en) * | 2007-06-05 | 2008-12-18 | Viswanathan Raju R | Method and apparatus for CTO crossing |
US20080319303A1 (en) * | 2003-05-02 | 2008-12-25 | Sabo Michael E | Variable magnetic moment mr navigation |
US20090012821A1 (en) * | 2007-07-06 | 2009-01-08 | Guy Besson | Management of live remote medical display |
US20090062646A1 (en) * | 2005-07-07 | 2009-03-05 | Creighton Iv Francis M | Operation of a remote medical navigation system using ultrasound image |
US20090082722A1 (en) * | 2007-08-21 | 2009-03-26 | Munger Gareth T | Remote navigation advancer devices and methods of use |
US20090105579A1 (en) * | 2007-10-19 | 2009-04-23 | Garibaldi Jeffrey M | Method and apparatus for remotely controlled navigation using diagnostically enhanced intra-operative three-dimensional image data |
US20090131927A1 (en) * | 2007-11-20 | 2009-05-21 | Nathan Kastelein | Method and apparatus for remote detection of rf ablation |
US7543239B2 (en) | 2004-06-04 | 2009-06-02 | Stereotaxis, Inc. | User interface for remote control of medical devices |
US20090177037A1 (en) * | 2007-06-27 | 2009-07-09 | Viswanathan Raju R | Remote control of medical devices using real time location data |
US20090177032A1 (en) * | 1999-04-14 | 2009-07-09 | Garibaldi Jeffrey M | Method and apparatus for magnetically controlling endoscopes in body lumens and cavities |
US20090306643A1 (en) * | 2008-02-25 | 2009-12-10 | Carlo Pappone | Method and apparatus for delivery and detection of transmural cardiac ablation lesions |
US20100069733A1 (en) * | 2008-09-05 | 2010-03-18 | Nathan Kastelein | Electrophysiology catheter with electrode loop |
US20100163061A1 (en) * | 2000-04-11 | 2010-07-01 | Creighton Francis M | Magnets with varying magnetization direction and method of making such magnets |
US7751867B2 (en) | 2004-12-20 | 2010-07-06 | Stereotaxis, Inc. | Contact over-torque with three-dimensional anatomical data |
US20100222669A1 (en) * | 2006-08-23 | 2010-09-02 | William Flickinger | Medical device guide |
US7818076B2 (en) | 2005-07-26 | 2010-10-19 | Stereotaxis, Inc. | Method and apparatus for multi-system remote surgical navigation from a single control center |
US7831294B2 (en) | 2004-10-07 | 2010-11-09 | Stereotaxis, Inc. | System and method of surgical imagining with anatomical overlay for navigation of surgical devices |
US20100298845A1 (en) * | 2009-05-25 | 2010-11-25 | Kidd Brian L | Remote manipulator device |
US20100305502A1 (en) * | 2001-05-06 | 2010-12-02 | Ferry Steven J | Systems and methods for medical device advancement and rotation |
US20110046618A1 (en) * | 2009-08-04 | 2011-02-24 | Minar Christopher D | Methods and systems for treating occluded blood vessels and other body cannula |
WO2011030276A1 (en) * | 2009-09-14 | 2011-03-17 | Koninklijke Philips Electronics N.V. | Apparatus and method for controlling the movement and for localization of a catheter |
US7918857B2 (en) | 2006-09-26 | 2011-04-05 | Depuy Spine, Inc. | Minimally invasive bone anchor extensions |
US20110130718A1 (en) * | 2009-05-25 | 2011-06-02 | Kidd Brian L | Remote Manipulator Device |
US7961924B2 (en) | 2006-08-21 | 2011-06-14 | Stereotaxis, Inc. | Method of three-dimensional device localization using single-plane imaging |
US8231618B2 (en) | 2007-11-05 | 2012-07-31 | Stereotaxis, Inc. | Magnetically guided energy delivery apparatus |
US8242972B2 (en) | 2006-09-06 | 2012-08-14 | Stereotaxis, Inc. | System state driven display for medical procedures |
US8308628B2 (en) | 2009-11-02 | 2012-11-13 | Pulse Therapeutics, Inc. | Magnetic-based systems for treating occluded vessels |
US8419681B2 (en) | 2002-11-18 | 2013-04-16 | Stereotaxis, Inc. | Magnetically navigable balloon catheters |
US8523916B2 (en) | 2003-12-16 | 2013-09-03 | DePuy Synthes Products, LLC | Methods and devices for spinal fixation element placement |
US9883878B2 (en) | 2012-05-15 | 2018-02-06 | Pulse Therapeutics, Inc. | Magnetic-based systems and methods for manipulation of magnetic particles |
US20220305274A1 (en) * | 2020-09-16 | 2022-09-29 | Industry Foundation Of Chonnam National University | Multi leadless pacemaker and surgical device |
US11918315B2 (en) | 2018-05-03 | 2024-03-05 | Pulse Therapeutics, Inc. | Determination of structure and traversal of occlusions using magnetic particles |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030009094A1 (en) * | 2000-11-15 | 2003-01-09 | Segner Garland L. | Electrophysiology catheter |
US6662034B2 (en) * | 2000-11-15 | 2003-12-09 | Stereotaxis, Inc. | Magnetically guidable electrophysiology catheter |
US20060069429A1 (en) * | 2001-04-24 | 2006-03-30 | Spence Paul A | Tissue fastening systems and methods utilizing magnetic guidance |
US8202315B2 (en) | 2001-04-24 | 2012-06-19 | Mitralign, Inc. | Catheter-based annuloplasty using ventricularly positioned catheter |
US20050125011A1 (en) * | 2001-04-24 | 2005-06-09 | Spence Paul A. | Tissue fastening systems and methods utilizing magnetic guidance |
US7769427B2 (en) * | 2002-07-16 | 2010-08-03 | Magnetics, Inc. | Apparatus and method for catheter guidance control and imaging |
NZ539136A (en) * | 2002-10-21 | 2008-04-30 | Mitralign Inc | Method and apparatus for performing catheter-based annuloplasty using local plications |
US20050119735A1 (en) * | 2002-10-21 | 2005-06-02 | Spence Paul A. | Tissue fastening systems and methods utilizing magnetic guidance |
US7280863B2 (en) * | 2003-10-20 | 2007-10-09 | Magnetecs, Inc. | System and method for radar-assisted catheter guidance and control |
EP1547540A1 (en) * | 2003-11-28 | 2005-06-29 | Siemens Aktiengesellschaft | Apparatus for directing a magnetic element in a body of a patient |
US7166127B2 (en) * | 2003-12-23 | 2007-01-23 | Mitralign, Inc. | Tissue fastening systems and methods utilizing magnetic guidance |
US8864822B2 (en) | 2003-12-23 | 2014-10-21 | Mitralign, Inc. | Devices and methods for introducing elements into tissue |
US8027714B2 (en) * | 2005-05-27 | 2011-09-27 | Magnetecs, Inc. | Apparatus and method for shaped magnetic field control for catheter, guidance, control, and imaging |
US8951285B2 (en) | 2005-07-05 | 2015-02-10 | Mitralign, Inc. | Tissue anchor, anchoring system and methods of using the same |
US20070040670A1 (en) * | 2005-07-26 | 2007-02-22 | Viswanathan Raju R | System and network for remote medical procedures |
US8784336B2 (en) | 2005-08-24 | 2014-07-22 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
CN101316560B (en) * | 2005-12-02 | 2011-01-26 | 皇家飞利浦电子股份有限公司 | Automating the ablation procedure to minimize the need for manual intervention |
US7869854B2 (en) * | 2006-02-23 | 2011-01-11 | Magnetecs, Inc. | Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation |
WO2007139809A2 (en) * | 2006-05-23 | 2007-12-06 | Dentatek Corporation | Root canal filling materials and methods |
US8388546B2 (en) | 2006-10-23 | 2013-03-05 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US7794407B2 (en) | 2006-10-23 | 2010-09-14 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US8845723B2 (en) | 2007-03-13 | 2014-09-30 | Mitralign, Inc. | Systems and methods for introducing elements into tissue |
US8911461B2 (en) | 2007-03-13 | 2014-12-16 | Mitralign, Inc. | Suture cutter and method of cutting suture |
US20080249395A1 (en) * | 2007-04-06 | 2008-10-09 | Yehoshua Shachar | Method and apparatus for controlling catheter positioning and orientation |
US20090131798A1 (en) * | 2007-11-19 | 2009-05-21 | Minar Christopher D | Method and apparatus for intravascular imaging and occlusion crossing |
US10449330B2 (en) | 2007-11-26 | 2019-10-22 | C. R. Bard, Inc. | Magnetic element-equipped needle assemblies |
US8388541B2 (en) | 2007-11-26 | 2013-03-05 | C. R. Bard, Inc. | Integrated system for intravascular placement of a catheter |
US9649048B2 (en) | 2007-11-26 | 2017-05-16 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
US9521961B2 (en) | 2007-11-26 | 2016-12-20 | C. R. Bard, Inc. | Systems and methods for guiding a medical instrument |
US10751509B2 (en) | 2007-11-26 | 2020-08-25 | C. R. Bard, Inc. | Iconic representations for guidance of an indwelling medical device |
US10524691B2 (en) | 2007-11-26 | 2020-01-07 | C. R. Bard, Inc. | Needle assembly including an aligned magnetic element |
US8781555B2 (en) | 2007-11-26 | 2014-07-15 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
US8849382B2 (en) | 2007-11-26 | 2014-09-30 | C. R. Bard, Inc. | Apparatus and display methods relating to intravascular placement of a catheter |
US8478382B2 (en) | 2008-02-11 | 2013-07-02 | C. R. Bard, Inc. | Systems and methods for positioning a catheter |
US20090275828A1 (en) * | 2008-05-01 | 2009-11-05 | Magnetecs, Inc. | Method and apparatus for creating a high resolution map of the electrical and mechanical properties of the heart |
US9901714B2 (en) | 2008-08-22 | 2018-02-27 | C. R. Bard, Inc. | Catheter assembly including ECG sensor and magnetic assemblies |
US8437833B2 (en) | 2008-10-07 | 2013-05-07 | Bard Access Systems, Inc. | Percutaneous magnetic gastrostomy |
US20100125282A1 (en) * | 2008-11-14 | 2010-05-20 | Medtronic Vascular, Inc. | Robotically Steered RF Catheter |
US8457714B2 (en) * | 2008-11-25 | 2013-06-04 | Magnetecs, Inc. | System and method for a catheter impedance seeking device |
US11890226B2 (en) | 2009-02-25 | 2024-02-06 | University Of Maryland, College Park | Device and methods for directing agents into an eye |
US8316862B2 (en) * | 2009-02-25 | 2012-11-27 | University Of Maryland | Devices, systems and methods for magnetic-assisted therapeutic agent delivery |
US9532724B2 (en) | 2009-06-12 | 2017-01-03 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
EP3542713A1 (en) | 2009-06-12 | 2019-09-25 | Bard Access Systems, Inc. | Adapter for a catheter tip positioning device |
WO2011019760A2 (en) | 2009-08-10 | 2011-02-17 | Romedex International Srl | Devices and methods for endovascular electrography |
EP2517622A3 (en) | 2009-09-29 | 2013-04-24 | C. R. Bard, Inc. | Stylets for use with apparatus for intravascular placement of a catheter |
US11103213B2 (en) | 2009-10-08 | 2021-08-31 | C. R. Bard, Inc. | Spacers for use with an ultrasound probe |
US20110092808A1 (en) * | 2009-10-20 | 2011-04-21 | Magnetecs, Inc. | Method for acquiring high density mapping data with a catheter guidance system |
US20110091853A1 (en) * | 2009-10-20 | 2011-04-21 | Magnetecs, Inc. | Method for simulating a catheter guidance system for control, development and training applications |
US20110112396A1 (en) * | 2009-11-09 | 2011-05-12 | Magnetecs, Inc. | System and method for targeting catheter electrodes |
CN102821679B (en) | 2010-02-02 | 2016-04-27 | C·R·巴德股份有限公司 | For the apparatus and method that catheter navigation and end are located |
JP5980201B2 (en) | 2010-05-28 | 2016-08-31 | シー・アール・バード・インコーポレーテッドC R Bard Incorporated | Insertion guidance system for needles and medical components |
WO2011150376A1 (en) | 2010-05-28 | 2011-12-01 | C.R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
JP2013535301A (en) | 2010-08-09 | 2013-09-12 | シー・アール・バード・インコーポレーテッド | Ultrasonic probe head support / cover structure |
BR112013002431B1 (en) | 2010-08-20 | 2021-06-29 | C.R. Bard, Inc | SYSTEM FOR RECONFIRMING THE POSITION OF A CATHETER INSIDE A PATIENT |
EP2632360A4 (en) | 2010-10-29 | 2014-05-21 | Bard Inc C R | Bioimpedance-assisted placement of a medical device |
KR20140051284A (en) | 2011-07-06 | 2014-04-30 | 씨. 알. 바드, 인크. | Needle length determination and calibration for insertion guidance system |
USD699359S1 (en) | 2011-08-09 | 2014-02-11 | C. R. Bard, Inc. | Ultrasound probe head |
USD724745S1 (en) | 2011-08-09 | 2015-03-17 | C. R. Bard, Inc. | Cap for an ultrasound probe |
WO2013070775A1 (en) | 2011-11-07 | 2013-05-16 | C.R. Bard, Inc | Ruggedized ultrasound hydrogel insert |
WO2013188833A2 (en) | 2012-06-15 | 2013-12-19 | C.R. Bard, Inc. | Apparatus and methods for detection of a removable cap on an ultrasound probe |
US10070857B2 (en) | 2013-08-31 | 2018-09-11 | Mitralign, Inc. | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
CN105979868B (en) | 2014-02-06 | 2020-03-10 | C·R·巴德股份有限公司 | Systems and methods for guidance and placement of intravascular devices |
US10973584B2 (en) | 2015-01-19 | 2021-04-13 | Bard Access Systems, Inc. | Device and method for vascular access |
US10349890B2 (en) | 2015-06-26 | 2019-07-16 | C. R. Bard, Inc. | Connector interface for ECG-based catheter positioning system |
KR20180088656A (en) | 2015-11-25 | 2018-08-06 | 탈론 메디컬, 엘엘씨 | Tissue coupling device, system, and method |
US11000207B2 (en) | 2016-01-29 | 2021-05-11 | C. R. Bard, Inc. | Multiple coil system for tracking a medical device |
US10992079B2 (en) | 2018-10-16 | 2021-04-27 | Bard Access Systems, Inc. | Safety-equipped connection systems and methods thereof for establishing electrical connections |
CN112294437B (en) * | 2020-10-08 | 2021-09-14 | 哈尔滨工业大学 | Positioning based on magnetic gradiometer array and design method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5507744A (en) * | 1992-04-23 | 1996-04-16 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
US5694945A (en) * | 1993-07-20 | 1997-12-09 | Biosense, Inc. | Apparatus and method for intrabody mapping |
US5766164A (en) * | 1996-07-03 | 1998-06-16 | Eclipse Surgical Technologies, Inc. | Contiguous, branched transmyocardial revascularization (TMR) channel, method and device |
US6015414A (en) * | 1997-08-29 | 2000-01-18 | Stereotaxis, Inc. | Method and apparatus for magnetically controlling motion direction of a mechanically pushed catheter |
US6224566B1 (en) * | 1999-05-04 | 2001-05-01 | Cardiodyne, Inc. | Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5327889A (en) | 1992-12-01 | 1994-07-12 | Cardiac Pathways Corporation | Mapping and ablation catheter with individually deployable arms and method |
US5263493A (en) | 1992-02-24 | 1993-11-23 | Boaz Avitall | Deflectable loop electrode array mapping and ablation catheter for cardiac chambers |
US5324284A (en) | 1992-06-05 | 1994-06-28 | Cardiac Pathways, Inc. | Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method |
US5476495A (en) | 1993-03-16 | 1995-12-19 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US5738096A (en) | 1993-07-20 | 1998-04-14 | Biosense, Inc. | Cardiac electromechanics |
US5487385A (en) | 1993-12-03 | 1996-01-30 | Avitall; Boaz | Atrial mapping and ablation catheter system |
US5454370A (en) | 1993-12-03 | 1995-10-03 | Avitall; Boaz | Mapping and ablation electrode configuration |
US5429131A (en) * | 1994-02-25 | 1995-07-04 | The Regents Of The University Of California | Magnetized electrode tip catheter |
US5718241A (en) | 1995-06-07 | 1998-02-17 | Biosense, Inc. | Apparatus and method for treating cardiac arrhythmias with no discrete target |
US5752513A (en) | 1995-06-07 | 1998-05-19 | Biosense, Inc. | Method and apparatus for determining position of object |
US5769843A (en) * | 1996-02-20 | 1998-06-23 | Cormedica | Percutaneous endomyocardial revascularization |
US5810836A (en) * | 1996-03-04 | 1998-09-22 | Myocardial Stents, Inc. | Device and method for trans myocardial revascularization (TMR) |
DE19622078A1 (en) | 1996-05-31 | 1997-12-04 | Siemens Ag | Active current localising appts. for heart |
US5921244A (en) * | 1997-06-11 | 1999-07-13 | Light Sciences Limited Partnership | Internal magnetic device to enhance drug therapy |
US5980548A (en) * | 1997-10-29 | 1999-11-09 | Kensey Nash Corporation | Transmyocardial revascularization system |
US6056743A (en) * | 1997-11-04 | 2000-05-02 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization device and method |
US6196230B1 (en) * | 1998-09-10 | 2001-03-06 | Percardia, Inc. | Stent delivery system and method of use |
US6248112B1 (en) * | 1998-09-30 | 2001-06-19 | C. R. Bard, Inc. | Implant delivery system |
US6298257B1 (en) * | 1999-09-22 | 2001-10-02 | Sterotaxis, Inc. | Cardiac methods and system |
US6464693B1 (en) * | 2000-03-06 | 2002-10-15 | Plc Medical Systems, Inc. | Myocardial revascularization |
-
1999
- 1999-09-19 AU AU38858/01A patent/AU3885801A/en not_active Abandoned
- 1999-09-20 US US09/398,686 patent/US6562019B1/en not_active Expired - Lifetime
-
2000
- 2000-09-19 WO PCT/US2000/025659 patent/WO2001021253A1/en active Application Filing
-
2003
- 2003-05-13 US US10/437,267 patent/US20040006301A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5507744A (en) * | 1992-04-23 | 1996-04-16 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
US5694945A (en) * | 1993-07-20 | 1997-12-09 | Biosense, Inc. | Apparatus and method for intrabody mapping |
US5766164A (en) * | 1996-07-03 | 1998-06-16 | Eclipse Surgical Technologies, Inc. | Contiguous, branched transmyocardial revascularization (TMR) channel, method and device |
US6015414A (en) * | 1997-08-29 | 2000-01-18 | Stereotaxis, Inc. | Method and apparatus for magnetically controlling motion direction of a mechanically pushed catheter |
US6224566B1 (en) * | 1999-05-04 | 2001-05-01 | Cardiodyne, Inc. | Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium |
Cited By (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070088077A1 (en) * | 1991-02-26 | 2007-04-19 | Plasse Terry F | Appetite stimulation and reduction of weight loss in patients suffering from symptomatic hiv infection |
US20070021731A1 (en) * | 1997-11-12 | 2007-01-25 | Garibaldi Jeffrey M | Method of and apparatus for navigating medical devices in body lumens |
US20070038074A1 (en) * | 1998-02-09 | 2007-02-15 | Ritter Rogers C | Method and device for locating magnetic implant source field |
US20070287909A1 (en) * | 1998-08-07 | 2007-12-13 | Stereotaxis, Inc. | Method and apparatus for magnetically controlling catheters in body lumens and cavities |
US20100063385A1 (en) * | 1998-08-07 | 2010-03-11 | Garibaldi Jeffrey M | Method and apparatus for magnetically controlling catheters in body lumens and cavities |
US20090177032A1 (en) * | 1999-04-14 | 2009-07-09 | Garibaldi Jeffrey M | Method and apparatus for magnetically controlling endoscopes in body lumens and cavities |
US20040106931A1 (en) * | 1999-08-04 | 2004-06-03 | Percardia, Inc. | Left ventricular conduits and methods for delivery |
US7757694B2 (en) | 1999-10-04 | 2010-07-20 | Stereotaxis, Inc. | Method for safely and efficiently navigating magnetic devices in the body |
US20070146106A1 (en) * | 1999-10-04 | 2007-06-28 | Creighton Francis M Iv | Rotating and pivoting magnet for magnetic navigation |
US7771415B2 (en) | 1999-10-04 | 2010-08-10 | Stereotaxis, Inc. | Method for safely and efficiently navigating magnetic devices in the body |
US20080047568A1 (en) * | 1999-10-04 | 2008-02-28 | Ritter Rogers C | Method for Safely and Efficiently Navigating Magnetic Devices in the Body |
US7966059B2 (en) | 1999-10-04 | 2011-06-21 | Stereotaxis, Inc. | Rotating and pivoting magnet for magnetic navigation |
US20070088197A1 (en) * | 2000-02-16 | 2007-04-19 | Sterotaxis, Inc. | Magnetic medical devices with changeable magnetic moments and method of navigating magnetic medical devices with changeable magnetic moments |
US7341063B2 (en) | 2000-02-16 | 2008-03-11 | Stereotaxis, Inc. | Magnetic medical devices with changeable magnetic moments and method of navigating magnetic medical devices with changeable magnetic moments |
US20100163061A1 (en) * | 2000-04-11 | 2010-07-01 | Creighton Francis M | Magnets with varying magnetization direction and method of making such magnets |
US20020045928A1 (en) * | 2000-05-04 | 2002-04-18 | Percardia, Inc. | Methods and devices for delivering a ventricular stent |
US20020032478A1 (en) * | 2000-08-07 | 2002-03-14 | Percardia, Inc. | Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel |
US20020099404A1 (en) * | 2001-01-25 | 2002-07-25 | Mowry David H. | Intravascular ventriculocoronary artery bypass delivery modalities |
US20080045892A1 (en) * | 2001-05-06 | 2008-02-21 | Ferry Steven J | System and Methods for Advancing a Catheter |
US8114032B2 (en) * | 2001-05-06 | 2012-02-14 | Stereotaxis, Inc. | Systems and methods for medical device advancement and rotation |
US20100305502A1 (en) * | 2001-05-06 | 2010-12-02 | Ferry Steven J | Systems and methods for medical device advancement and rotation |
US7766856B2 (en) | 2001-05-06 | 2010-08-03 | Stereotaxis, Inc. | System and methods for advancing a catheter |
US7276044B2 (en) | 2001-05-06 | 2007-10-02 | Stereotaxis, Inc. | System and methods for advancing a catheter |
US20020177789A1 (en) * | 2001-05-06 | 2002-11-28 | Ferry Steven J. | System and methods for advancing a catheter |
US20040210190A1 (en) * | 2001-08-16 | 2004-10-21 | Percardia, Inc. | Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts |
US20080016677A1 (en) * | 2002-01-23 | 2008-01-24 | Stereotaxis, Inc. | Rotating and pivoting magnet for magnetic navigation |
US20050214342A1 (en) * | 2002-02-13 | 2005-09-29 | Percardia, Inc. | Cardiac implant and methods |
US20030158509A1 (en) * | 2002-02-13 | 2003-08-21 | Tweden Katherine S. | Cardiac implant and methods |
US20040169316A1 (en) * | 2002-03-28 | 2004-09-02 | Siliconix Taiwan Ltd. | Encapsulation method and leadframe for leadless semiconductor packages |
US20030220661A1 (en) * | 2002-05-21 | 2003-11-27 | Heartstent Corporation | Transmyocardial implant delivery system |
US8060184B2 (en) | 2002-06-28 | 2011-11-15 | Stereotaxis, Inc. | Method of navigating medical devices in the presence of radiopaque material |
US20080077007A1 (en) * | 2002-06-28 | 2008-03-27 | Hastings Roger N | Method of Navigating Medical Devices in the Presence of Radiopaque Material |
US8419681B2 (en) | 2002-11-18 | 2013-04-16 | Stereotaxis, Inc. | Magnetically navigable balloon catheters |
US20080319303A1 (en) * | 2003-05-02 | 2008-12-25 | Sabo Michael E | Variable magnetic moment mr navigation |
US8196590B2 (en) | 2003-05-02 | 2012-06-12 | Stereotaxis, Inc. | Variable magnetic moment MR navigation |
US20060278246A1 (en) * | 2003-05-21 | 2006-12-14 | Michael Eng | Electrophysiology catheter |
US7346379B2 (en) | 2003-05-21 | 2008-03-18 | Stereotaxis, Inc. | Electrophysiology catheter |
US20050113812A1 (en) * | 2003-09-16 | 2005-05-26 | Viswanathan Raju R. | User interface for remote control of medical devices |
US10039578B2 (en) | 2003-12-16 | 2018-08-07 | DePuy Synthes Products, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US7708763B2 (en) * | 2003-12-16 | 2010-05-04 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US20050154389A1 (en) * | 2003-12-16 | 2005-07-14 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US9161786B2 (en) | 2003-12-16 | 2015-10-20 | DePuy Synthes Products, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US8721692B2 (en) | 2003-12-16 | 2014-05-13 | Depuy Synthes Products Llc | Methods and devices for spinal fixation element placement |
US8523916B2 (en) | 2003-12-16 | 2013-09-03 | DePuy Synthes Products, LLC | Methods and devices for spinal fixation element placement |
US11426216B2 (en) | 2003-12-16 | 2022-08-30 | DePuy Synthes Products, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US20090138056A1 (en) * | 2003-12-16 | 2009-05-28 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US11241262B2 (en) | 2003-12-16 | 2022-02-08 | DePuy Synthes Products, Inc. | Methods and devices for spinal fixation element placement |
US10413338B2 (en) | 2003-12-16 | 2019-09-17 | DePuy Synthes Products, Inc. | Methods and devices for spinal fixation element placement |
US9216040B2 (en) | 2003-12-16 | 2015-12-22 | DePuy Synthes Products, Inc. | Methods and devices for spinal fixation element placement |
US8277491B2 (en) | 2003-12-16 | 2012-10-02 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US9888947B2 (en) | 2003-12-16 | 2018-02-13 | DePuy Synthes Products, Inc. | Methods and devices for spinal fixation element placement |
US8105361B2 (en) | 2003-12-16 | 2012-01-31 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US8734490B2 (en) | 2003-12-16 | 2014-05-27 | DePuy Synthes Products, LLC | Methods and devices for minimally invasive spinal fixation element placement |
US9750547B2 (en) | 2003-12-16 | 2017-09-05 | DePuy Synthes Products, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
US7543239B2 (en) | 2004-06-04 | 2009-06-02 | Stereotaxis, Inc. | User interface for remote control of medical devices |
US20060036163A1 (en) * | 2004-07-19 | 2006-02-16 | Viswanathan Raju R | Method of, and apparatus for, controlling medical navigation systems |
US20080006280A1 (en) * | 2004-07-20 | 2008-01-10 | Anthony Aliberto | Magnetic navigation maneuvering sheath |
US20060144407A1 (en) * | 2004-07-20 | 2006-07-06 | Anthony Aliberto | Magnetic navigation manipulation apparatus |
US20060144408A1 (en) * | 2004-07-23 | 2006-07-06 | Ferry Steven J | Micro-catheter device and method of using same |
US20060052656A1 (en) * | 2004-09-09 | 2006-03-09 | The Regents Of The University Of California | Implantable devices using magnetic guidance |
US7831294B2 (en) | 2004-10-07 | 2010-11-09 | Stereotaxis, Inc. | System and method of surgical imagining with anatomical overlay for navigation of surgical devices |
US7751867B2 (en) | 2004-12-20 | 2010-07-06 | Stereotaxis, Inc. | Contact over-torque with three-dimensional anatomical data |
US8369934B2 (en) | 2004-12-20 | 2013-02-05 | Stereotaxis, Inc. | Contact over-torque with three-dimensional anatomical data |
US20110022029A1 (en) * | 2004-12-20 | 2011-01-27 | Viswanathan Raju R | Contact over-torque with three-dimensional anatomical data |
US7708696B2 (en) | 2005-01-11 | 2010-05-04 | Stereotaxis, Inc. | Navigation using sensed physiological data as feedback |
US20060270915A1 (en) * | 2005-01-11 | 2006-11-30 | Ritter Rogers C | Navigation using sensed physiological data as feedback |
US20060269108A1 (en) * | 2005-02-07 | 2006-11-30 | Viswanathan Raju R | Registration of three dimensional image data to 2D-image-derived data |
US7961926B2 (en) | 2005-02-07 | 2011-06-14 | Stereotaxis, Inc. | Registration of three-dimensional image data to 2D-image-derived data |
US7756308B2 (en) | 2005-02-07 | 2010-07-13 | Stereotaxis, Inc. | Registration of three dimensional image data to 2D-image-derived data |
US20110033100A1 (en) * | 2005-02-07 | 2011-02-10 | Viswanathan Raju R | Registration of three-dimensional image data to 2d-image-derived data |
US7742803B2 (en) | 2005-05-06 | 2010-06-22 | Stereotaxis, Inc. | Voice controlled user interface for remote navigation systems |
US20060281990A1 (en) * | 2005-05-06 | 2006-12-14 | Viswanathan Raju R | User interfaces and navigation methods for vascular navigation |
US20060281989A1 (en) * | 2005-05-06 | 2006-12-14 | Viswanathan Raju R | Voice controlled user interface for remote navigation systems |
US20060276867A1 (en) * | 2005-06-02 | 2006-12-07 | Viswanathan Raju R | Methods and devices for mapping the ventricle for pacing lead placement and therapy delivery |
US20070060992A1 (en) * | 2005-06-02 | 2007-03-15 | Carlo Pappone | Methods and devices for mapping the ventricle for pacing lead placement and therapy delivery |
US20070062546A1 (en) * | 2005-06-02 | 2007-03-22 | Viswanathan Raju R | Electrophysiology catheter and system for gentle and firm wall contact |
US20090062646A1 (en) * | 2005-07-07 | 2009-03-05 | Creighton Iv Francis M | Operation of a remote medical navigation system using ultrasound image |
US20070038065A1 (en) * | 2005-07-07 | 2007-02-15 | Creighton Francis M Iv | Operation of a remote medical navigation system using ultrasound image |
US20070021744A1 (en) * | 2005-07-07 | 2007-01-25 | Creighton Francis M Iv | Apparatus and method for performing ablation with imaging feedback |
US9314222B2 (en) | 2005-07-07 | 2016-04-19 | Stereotaxis, Inc. | Operation of a remote medical navigation system using ultrasound image |
US7603905B2 (en) | 2005-07-08 | 2009-10-20 | Stereotaxis, Inc. | Magnetic navigation and imaging system |
US20070038064A1 (en) * | 2005-07-08 | 2007-02-15 | Creighton Francis M Iv | Magnetic navigation and imaging system |
US20070060966A1 (en) * | 2005-07-11 | 2007-03-15 | Carlo Pappone | Method of treating cardiac arrhythmias |
US7769444B2 (en) | 2005-07-11 | 2010-08-03 | Stereotaxis, Inc. | Method of treating cardiac arrhythmias |
US20070016131A1 (en) * | 2005-07-12 | 2007-01-18 | Munger Gareth T | Flexible magnets for navigable medical devices |
US20070019330A1 (en) * | 2005-07-12 | 2007-01-25 | Charles Wolfersberger | Apparatus for pivotally orienting a projection device |
US7416335B2 (en) | 2005-07-15 | 2008-08-26 | Sterotaxis, Inc. | Magnetically shielded x-ray tube |
US20070030958A1 (en) * | 2005-07-15 | 2007-02-08 | Munger Gareth T | Magnetically shielded x-ray tube |
US20070021742A1 (en) * | 2005-07-18 | 2007-01-25 | Viswanathan Raju R | Estimation of contact force by a medical device |
US8192374B2 (en) | 2005-07-18 | 2012-06-05 | Stereotaxis, Inc. | Estimation of contact force by a medical device |
US20070060829A1 (en) * | 2005-07-21 | 2007-03-15 | Carlo Pappone | Method of finding the source of and treating cardiac arrhythmias |
US20070062547A1 (en) * | 2005-07-21 | 2007-03-22 | Carlo Pappone | Systems for and methods of tissue ablation |
US20110087237A1 (en) * | 2005-07-26 | 2011-04-14 | Viswanathan Raju R | Method and apparatus for multi-system remote surgical navigation from a single control center |
US20070060962A1 (en) * | 2005-07-26 | 2007-03-15 | Carlo Pappone | Apparatus and methods for cardiac resynchronization therapy and cardiac contractility modulation |
US7818076B2 (en) | 2005-07-26 | 2010-10-19 | Stereotaxis, Inc. | Method and apparatus for multi-system remote surgical navigation from a single control center |
US20070043455A1 (en) * | 2005-07-26 | 2007-02-22 | Viswanathan Raju R | Apparatus and methods for automated sequential movement control for operation of a remote navigation system |
US7495537B2 (en) | 2005-08-10 | 2009-02-24 | Stereotaxis, Inc. | Method and apparatus for dynamic magnetic field control using multiple magnets |
US20070038410A1 (en) * | 2005-08-10 | 2007-02-15 | Ilker Tunay | Method and apparatus for dynamic magnetic field control using multiple magnets |
US7772950B2 (en) | 2005-08-10 | 2010-08-10 | Stereotaxis, Inc. | Method and apparatus for dynamic magnetic field control using multiple magnets |
US20070055124A1 (en) * | 2005-09-01 | 2007-03-08 | Viswanathan Raju R | Method and system for optimizing left-heart lead placement |
US20070167720A1 (en) * | 2005-12-06 | 2007-07-19 | Viswanathan Raju R | Smart card control of medical devices |
US20070149946A1 (en) * | 2005-12-07 | 2007-06-28 | Viswanathan Raju R | Advancer system for coaxial medical devices |
US20100168549A1 (en) * | 2006-01-06 | 2010-07-01 | Carlo Pappone | Electrophysiology catheter and system for gentle and firm wall contact |
US20070161882A1 (en) * | 2006-01-06 | 2007-07-12 | Carlo Pappone | Electrophysiology catheter and system for gentle and firm wall contact |
US20070179492A1 (en) * | 2006-01-06 | 2007-08-02 | Carlo Pappone | Electrophysiology catheter and system for gentle and firm wall contact |
US20080015670A1 (en) * | 2006-01-17 | 2008-01-17 | Carlo Pappone | Methods and devices for cardiac ablation |
US20070197899A1 (en) * | 2006-01-17 | 2007-08-23 | Ritter Rogers C | Apparatus and method for magnetic navigation using boost magnets |
US20070197906A1 (en) * | 2006-01-24 | 2007-08-23 | Ritter Rogers C | Magnetic field shape-adjustable medical device and method of using the same |
US20070250041A1 (en) * | 2006-04-19 | 2007-10-25 | Werp Peter R | Extendable Interventional Medical Devices |
US20080015427A1 (en) * | 2006-06-30 | 2008-01-17 | Nathan Kastelein | System and network for remote medical procedures |
US20080039830A1 (en) * | 2006-08-14 | 2008-02-14 | Munger Gareth T | Method and Apparatus for Ablative Recanalization of Blocked Vasculature |
US7961924B2 (en) | 2006-08-21 | 2011-06-14 | Stereotaxis, Inc. | Method of three-dimensional device localization using single-plane imaging |
US20100222669A1 (en) * | 2006-08-23 | 2010-09-02 | William Flickinger | Medical device guide |
US20080059598A1 (en) * | 2006-09-06 | 2008-03-06 | Garibaldi Jeffrey M | Coordinated Control for Multiple Computer-Controlled Medical Systems |
US7747960B2 (en) | 2006-09-06 | 2010-06-29 | Stereotaxis, Inc. | Control for, and method of, operating at least two medical systems |
US20080058609A1 (en) * | 2006-09-06 | 2008-03-06 | Stereotaxis, Inc. | Workflow driven method of performing multi-step medical procedures |
US8244824B2 (en) | 2006-09-06 | 2012-08-14 | Stereotaxis, Inc. | Coordinated control for multiple computer-controlled medical systems |
US8799792B2 (en) | 2006-09-06 | 2014-08-05 | Stereotaxis, Inc. | Workflow driven method of performing multi-step medical procedures |
US8806359B2 (en) | 2006-09-06 | 2014-08-12 | Stereotaxis, Inc. | Workflow driven display for medical procedures |
US7567233B2 (en) | 2006-09-06 | 2009-07-28 | Stereotaxis, Inc. | Global input device for multiple computer-controlled medical systems |
US20080064933A1 (en) * | 2006-09-06 | 2008-03-13 | Stereotaxis, Inc. | Workflow driven display for medical procedures |
US8242972B2 (en) | 2006-09-06 | 2012-08-14 | Stereotaxis, Inc. | System state driven display for medical procedures |
US20100097315A1 (en) * | 2006-09-06 | 2010-04-22 | Garibaldi Jeffrey M | Global input device for multiple computer-controlled medical systems |
US20080055239A1 (en) * | 2006-09-06 | 2008-03-06 | Garibaldi Jeffrey M | Global Input Device for Multiple Computer-Controlled Medical Systems |
US20080065061A1 (en) * | 2006-09-08 | 2008-03-13 | Viswanathan Raju R | Impedance-Based Cardiac Therapy Planning Method with a Remote Surgical Navigation System |
US8273081B2 (en) | 2006-09-08 | 2012-09-25 | Stereotaxis, Inc. | Impedance-based cardiac therapy planning method with a remote surgical navigation system |
US7537570B2 (en) | 2006-09-11 | 2009-05-26 | Stereotaxis, Inc. | Automated mapping of anatomical features of heart chambers |
US20080064969A1 (en) * | 2006-09-11 | 2008-03-13 | Nathan Kastelein | Automated Mapping of Anatomical Features of Heart Chambers |
US7918858B2 (en) | 2006-09-26 | 2011-04-05 | Depuy Spine, Inc. | Minimally invasive bone anchor extensions |
US7918857B2 (en) | 2006-09-26 | 2011-04-05 | Depuy Spine, Inc. | Minimally invasive bone anchor extensions |
US8828007B2 (en) | 2006-09-26 | 2014-09-09 | DePuy Synthes Products, LLC | Minimally invasive bone anchor extensions |
US20080097200A1 (en) * | 2006-10-20 | 2008-04-24 | Blume Walter M | Location and Display of Occluded Portions of Vessels on 3-D Angiographic Images |
US8135185B2 (en) | 2006-10-20 | 2012-03-13 | Stereotaxis, Inc. | Location and display of occluded portions of vessels on 3-D angiographic images |
US20080132910A1 (en) * | 2006-11-07 | 2008-06-05 | Carlo Pappone | Control for a Remote Navigation System |
US20080200913A1 (en) * | 2007-02-07 | 2008-08-21 | Viswanathan Raju R | Single Catheter Navigation for Diagnosis and Treatment of Arrhythmias |
US20080208912A1 (en) * | 2007-02-26 | 2008-08-28 | Garibaldi Jeffrey M | System and method for providing contextually relevant medical information |
US20080228068A1 (en) * | 2007-03-13 | 2008-09-18 | Viswanathan Raju R | Automated Surgical Navigation with Electro-Anatomical and Pre-Operative Image Data |
US20080228065A1 (en) * | 2007-03-13 | 2008-09-18 | Viswanathan Raju R | System and Method for Registration of Localization and Imaging Systems for Navigational Control of Medical Devices |
US20080287909A1 (en) * | 2007-05-17 | 2008-11-20 | Viswanathan Raju R | Method and apparatus for intra-chamber needle injection treatment |
US20080294232A1 (en) * | 2007-05-22 | 2008-11-27 | Viswanathan Raju R | Magnetic cell delivery |
US20080292901A1 (en) * | 2007-05-24 | 2008-11-27 | Hon Hai Precision Industry Co., Ltd. | Magnesium alloy and thin workpiece made of the same |
US20080312673A1 (en) * | 2007-06-05 | 2008-12-18 | Viswanathan Raju R | Method and apparatus for CTO crossing |
US20090177037A1 (en) * | 2007-06-27 | 2009-07-09 | Viswanathan Raju R | Remote control of medical devices using real time location data |
US8024024B2 (en) | 2007-06-27 | 2011-09-20 | Stereotaxis, Inc. | Remote control of medical devices using real time location data |
US9111016B2 (en) | 2007-07-06 | 2015-08-18 | Stereotaxis, Inc. | Management of live remote medical display |
US20090012821A1 (en) * | 2007-07-06 | 2009-01-08 | Guy Besson | Management of live remote medical display |
US20090082722A1 (en) * | 2007-08-21 | 2009-03-26 | Munger Gareth T | Remote navigation advancer devices and methods of use |
US20090105579A1 (en) * | 2007-10-19 | 2009-04-23 | Garibaldi Jeffrey M | Method and apparatus for remotely controlled navigation using diagnostically enhanced intra-operative three-dimensional image data |
US8231618B2 (en) | 2007-11-05 | 2012-07-31 | Stereotaxis, Inc. | Magnetically guided energy delivery apparatus |
US20090131927A1 (en) * | 2007-11-20 | 2009-05-21 | Nathan Kastelein | Method and apparatus for remote detection of rf ablation |
US20090306643A1 (en) * | 2008-02-25 | 2009-12-10 | Carlo Pappone | Method and apparatus for delivery and detection of transmural cardiac ablation lesions |
US20100069733A1 (en) * | 2008-09-05 | 2010-03-18 | Nathan Kastelein | Electrophysiology catheter with electrode loop |
US20100298845A1 (en) * | 2009-05-25 | 2010-11-25 | Kidd Brian L | Remote manipulator device |
US10537713B2 (en) | 2009-05-25 | 2020-01-21 | Stereotaxis, Inc. | Remote manipulator device |
US20110130718A1 (en) * | 2009-05-25 | 2011-06-02 | Kidd Brian L | Remote Manipulator Device |
US20110046618A1 (en) * | 2009-08-04 | 2011-02-24 | Minar Christopher D | Methods and systems for treating occluded blood vessels and other body cannula |
WO2011030276A1 (en) * | 2009-09-14 | 2011-03-17 | Koninklijke Philips Electronics N.V. | Apparatus and method for controlling the movement and for localization of a catheter |
CN102497811A (en) * | 2009-09-14 | 2012-06-13 | 皇家飞利浦电子股份有限公司 | Apparatus and method for controlling the movement and for localization of a catheter |
US9345498B2 (en) | 2009-11-02 | 2016-05-24 | Pulse Therapeutics, Inc. | Methods of controlling magnetic nanoparticles to improve vascular flow |
US8715150B2 (en) | 2009-11-02 | 2014-05-06 | Pulse Therapeutics, Inc. | Devices for controlling magnetic nanoparticles to treat fluid obstructions |
US9339664B2 (en) | 2009-11-02 | 2016-05-17 | Pulse Therapetics, Inc. | Control of magnetic rotors to treat therapeutic targets |
US10029008B2 (en) | 2009-11-02 | 2018-07-24 | Pulse Therapeutics, Inc. | Therapeutic magnetic control systems and contrast agents |
US8308628B2 (en) | 2009-11-02 | 2012-11-13 | Pulse Therapeutics, Inc. | Magnetic-based systems for treating occluded vessels |
US10159734B2 (en) | 2009-11-02 | 2018-12-25 | Pulse Therapeutics, Inc. | Magnetic particle control and visualization |
US8926491B2 (en) | 2009-11-02 | 2015-01-06 | Pulse Therapeutics, Inc. | Controlling magnetic nanoparticles to increase vascular flow |
US8313422B2 (en) | 2009-11-02 | 2012-11-20 | Pulse Therapeutics, Inc. | Magnetic-based methods for treating vessel obstructions |
US11612655B2 (en) | 2009-11-02 | 2023-03-28 | Pulse Therapeutics, Inc. | Magnetic particle control and visualization |
US10813997B2 (en) | 2009-11-02 | 2020-10-27 | Pulse Therapeutics, Inc. | Devices for controlling magnetic nanoparticles to treat fluid obstructions |
US11000589B2 (en) | 2009-11-02 | 2021-05-11 | Pulse Therapeutics, Inc. | Magnetic particle control and visualization |
US8529428B2 (en) | 2009-11-02 | 2013-09-10 | Pulse Therapeutics, Inc. | Methods of controlling magnetic nanoparticles to improve vascular flow |
US9883878B2 (en) | 2012-05-15 | 2018-02-06 | Pulse Therapeutics, Inc. | Magnetic-based systems and methods for manipulation of magnetic particles |
US10646241B2 (en) | 2012-05-15 | 2020-05-12 | Pulse Therapeutics, Inc. | Detection of fluidic current generated by rotating magnetic particles |
US11918315B2 (en) | 2018-05-03 | 2024-03-05 | Pulse Therapeutics, Inc. | Determination of structure and traversal of occlusions using magnetic particles |
US20220305274A1 (en) * | 2020-09-16 | 2022-09-29 | Industry Foundation Of Chonnam National University | Multi leadless pacemaker and surgical device |
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WO2001021253A1 (en) | 2001-03-29 |
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