US20040162571A1 - Apparatus and method for an ultrasonic medical device to treat deep vein thrombosis - Google Patents
Apparatus and method for an ultrasonic medical device to treat deep vein thrombosis Download PDFInfo
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- US20040162571A1 US20040162571A1 US10/779,250 US77925004A US2004162571A1 US 20040162571 A1 US20040162571 A1 US 20040162571A1 US 77925004 A US77925004 A US 77925004A US 2004162571 A1 US2004162571 A1 US 2004162571A1
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Definitions
- the present invention relates to medical devices, and more importantly to an apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis.
- DVT deep vein thrombosis
- PE pulmonary embolism
- DVT is a condition characterized by a reduction in blood flow, with several factors increasing the susceptibility of developing DVT.
- a person who has had a previous DVT condition is more likely to have a subsequent DVT condition.
- Immobility such as prolonged sitting, long travel, surgical procedures or the subsequent bed rest recovery from a surgical procedure, increases the probability of developing DVT.
- the probability of a DVT condition is increased by pregnancy, childbirth and the use of medications such as estrogen and birth control pills.
- People undergoing cancer treatments or having a history of polycythemia vera, malignant tumors and inherited or acquired hypercoagulability have a higher probability of developing DVT.
- the incidence of DVT is more common in people over 40 years of age in addition to individuals who are obese.
- U.S. Pat. No. 6,615,080 to Unsworth et al. discloses a single channel neuromuscular electrical stimulation device for the prevention of deep vein thrombosis, pulmonary embolism, lower extremity edema and other associated conditions by electrical stimulation of the muscles of the foot.
- Surface electrodes positioned over the foot muscles are attached to a stimulator that stimulates the foot muscles to reduce pooling of the blood in the soleal veins of the calf.
- the Unsworth et al. disclosure is limited to the soleal veins of the calf.
- the Unsworth et al. device does not engage the area of the blood clot or thrombus, but rather relies on electrical stimulation of the muscles to prevent DVT, pulmonary embolism and lower extremity edema.
- U.S. Pat. No. 6,290,662 to Morris et al. discloses an apparatus for deep vein thrombosis prophylaxis and other conditions comprising an inflatable/deflatable bladder disposed against an extremity such as the upper calf, foot or hand of a patient.
- An inelastic member of the Morris et al. device fully encloses the bladder and body part while compressive forces are directed against the body part when the bladder expands.
- the Morris et al. device does not directly engage the area of the blood clot or thrombus, but relies on the compressive forces to increase blood circulation and translate to the problematic area of the blood clot or thrombus.
- the Morris et al. device relies on a range of pressures that may be too high or too low depending on the patient and may not directly translate to increased blood flow.
- the prior art does not provide a solution for preventing and treating deep vein thrombosis in a safe, effective and time efficient manner.
- the prior art does not provide a solution for engaging the blood clot or the thrombus.
- Prior art instruments are limited in that they rely upon electrical stimulation of the muscles and transmission of the electrical simulation to the area of the blood clot or thrombus.
- Prior art instruments use high compressive forces to attempt to increase blood circulation. Therefore, there remains a need in the art for an apparatus and a method for an apparatus and a method of preventing and treating deep vein thrombosis that engages the blood clot or thrombus while not compromising the health of the patient.
- the present invention provides an apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis.
- the present invention is an ultrasonic medical device comprising a flexible, ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween.
- the ultrasonic medical device includes a transducer for creating a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the flexible, ultrasonic probe.
- a coupling engages the proximal end of the flexible, ultrasonic probe to a distal end of the transducer.
- An ultrasonic energy source engaged to the transducer produces an ultrasonic energy.
- the transverse ultrasonic vibration generates a plurality of transverse nodes and a plurality of transverse anti-nodes along at least a portion of the longitudinal axis of the flexible, ultrasonic probe, creating cavitation in a medium surrounding the flexible, ultrasonic probe to ablate a thrombus and treat deep vein thrombosis.
- the present invention is an ultrasonic medical device for treating deep vein thrombosis comprising an ultrasonic probe having a proximal end, a distal end terminating in a probe tip and a longitudinal axis between the proximal end and the distal end.
- the ultrasonic medical device includes a transducer that converts electrical energy into mechanical energy, creating a transverse ultrasonic vibration along the longitudinal axis of the ultrasonic probe.
- a coupling engages the proximal end of the ultrasonic probe to the distal end of the transducer.
- the transverse ultrasonic vibration produces a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of the ultrasonic probe.
- the present invention is a method of resolving deep vein thrombosis comprising: providing an ultrasonic medical device comprising an ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween; navigating the ultrasonic probe adjacent to a thrombus; placing the ultrasonic probe in communication with the thrombus; and activating an ultrasonic energy source engaged to the ultrasonic probe to generate a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the ultrasonic probe, wherein the transverse ultrasonic vibration creates a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of the ultrasonic probe.
- the present invention is a method of ablating a thrombus in a deep vein of a body comprising providing an ultrasonic medical device comprising an ultrasonic probe having a proximal end, a distal end terminating in a probe tip and a longitudinal axis between the proximal end and the distal end.
- the ultrasonic probe is inserted into an insertion point in the deep vein and moved to place the ultrasonic probe in communication with the thrombus.
- An ultrasonic energy source engaged to the ultrasonic probe is activated to produce an electric signal to drive a transducer of the ultrasonic medical device to generate a transverse ultrasonic vibration of the ultrasonic probe.
- the transverse ultrasonic vibration produces cavitation in a medium surrounding the ultrasonic probe to ablate the thrombus.
- the present invention provides an apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis.
- An ultrasonic probe is used to ablate a thrombus in a deep vein of the leg, preventing the thrombus, or a portion of the thrombus, from being carried with the blood to the heart and obstructing the flow of blood to one or more arteries in the lungs.
- the present invention provides an ultrasonic medical device that is simple, user-friendly, time efficient, reliable and cost effective.
- FIG. 1A is a side plan view of an ultrasonic probe of the present invention inserted into a tibial deep vein of a leg where the probe is moving toward a thrombus in the tibial vein.
- FIG. 1B is a side plan view of an ultrasonic probe of the present invention inserted into a popliteal deep vein of a leg where the probe is moving toward a thrombus in the popliteal vein.
- FIG. 2 is a side plan view of an ultrasonic medical device of the present invention capable of ablating a thrombus to treat deep vein thrombosis.
- FIG. 3 is a side plan view of an ultrasonic probe of the present invention having an approximately uniform diameter from a proximal end of the ultrasonic probe to the distal end of the ultrasonic probe.
- FIG. 4 is a view of a leg of a patient with deep veins, superficial veins and short veins.
- FIG. 5 is a view of a thrombus in a deep vein of a leg of a patient.
- FIG. 6 is a perspective view of an ultrasonic probe of the present invention inserted in a deep vein of a leg and being moved toward a thrombus in the deep vein.
- FIG. 7 is an enlarged view of an ultrasonic probe of the present invention in communication with a thrombus in a deep vein of a body.
- FIG. 8 is a view of an ultrasonic probe of the present invention showing a plurality of transverse nodes and a plurality of transverse anti-nodes while in communication with a thrombus in a deep vein of a body.
- the present invention provides an apparatus and a method for using an ultrasonic medical device to ablate a thrombus to treat deep vein thrombosis.
- the ultrasonic medical device comprises an ultrasonic probe, a transducer, a coupling engaging a proximal end of the ultrasonic probe to a distal end of the transducer and an ultrasonic energy source engaged to the transducer.
- the ultrasonic probe is inserted into a deep vein and placed in communication with the thrombus.
- the ultrasonic energy source produces an ultrasonic energy that is transmitted to the transducer, where the transducer creates a transverse ultrasonic vibration along the ultrasonic probe.
- the transverse ultrasonic vibration creates a plurality of transverse nodes and a plurality of transverse anti-nodes along the longitudinal axis of the ultrasonic probe, creating cavitation along a portion of the longitudinal axis of the ultrasonic probe to ablate the thrombus and treat deep vein thrombosis.
- the thrombus or a portion of the thrombus is not carried with the blood to the heart or the arteries of the lungs where a pulmonary embolism can occur.
- “Ablate” as used herein refers to removing, clearing, destroying or taking away a thrombus. “Ablation” as used herein refers to a removal, clearance, destruction, or taking away of the thrombus.
- Anti-node refers to a region of a maximum energy emitted by an ultrasonic probe at or proximal to a specific location along a longitudinal axis of the ultrasonic probe.
- Node refers to a region of a minimum energy emitted by an ultrasonic probe at or proximal to a specific location along a longitudinal axis of the ultrasonic probe.
- Probe refers to a device capable of propagating an energy emitted by the ultrasonic energy source along a longitudinal axis of the probe, resolving the energy into an effective cavitational energy at a specific resonance (defined by a plurality of nodes and a plurality of anti-nodes along an “active area” of the probe) and is capable of an acoustic impedance transformation of electrical energy to a mechanical energy.
- Thrombus refers to a collection of a matter including, but not limited to, a group of similar cells, intravascular blood clots, occlusions, plaque, biological material, fibrin, calcified plaque, calcium deposits, occlusional deposits, atherosclerotic plaque, fatty deposits, adipose tissues, atherosclerotic cholesterol buildup, fibrous material buildup, arterial stenoses, minerals, high water content tissues, platelets, cellular debris, wastes and other occlusive materials.
- Transverse refers to a vibration of a probe not parallel to a longitudinal axis of the probe.
- a “transverse wave” as used herein is a wave propagated along the probe in which a direction of a disturbance at a plurality of points of a medium is not parallel to a wave vector.
- FIG. 1A shows the ultrasonic probe 15 inserted at a lower calf of a leg 74 into a deep vein 75 of the leg 74 and adjacent to the thrombus 80 in the deep vein 75 .
- the ultrasonic probe 15 is inserted into a popliteal vein 72 in the lower calf area of the leg 74 .
- a flexibility of the ultrasonic probe allows the ultrasonic probe 15 to be navigated within the deep vein 75 .
- FIG. 1B shows the ultrasonic probe 15 inserted at a calf area into the deep vein 75 of the leg 74 and adjacent to the thrombus 80 in the deep vein 75 .
- the ultrasonic probe 15 is inserted into the tibial vein 72 .
- FIG. 2 shows an ultrasonic medical device capable of ablating a thrombus to treat deep vein thrombosis and prevent the thrombus from obstructing a vasculature in the body.
- the ultrasonic probe 15 is used to ablate a thrombus in a deep vein of a leg or a deep vein of a pelvis.
- the ultrasonic medical device 11 includes an ultrasonic probe 15 which is coupled to an ultrasonic energy source or generator 99 for the production of an ultrasonic energy.
- a handle, 88 comprising a proximal end 87 and a distal end 86 , surrounds a transducer within the handle 88 .
- the transducer having a proximal end engaging the ultrasonic energy source 99 and a distal end coupled to a proximal end 31 of the ultrasonic probe 15 , transmits the ultrasonic energy to the ultrasonic probe 15 .
- a connector 93 and a connecting wire 98 engage the ultrasonic energy source 99 to the transducer.
- the ultrasonic probe 15 includes the proximal end 31 , a distal end 24 that ends in a probe tip 9 and a longitudinal axis between the proximal end 31 and the distal end 24 . In a preferred embodiment of the present invention shown in FIG.
- a diameter of the ultrasonic probe decreases from a first defined interval 26 to a second defined interval 28 along the longitudinal axis of the ultrasonic probe 15 over a transition 82 .
- a coupling 33 that engages the proximal end 31 of the ultrasonic probe 15 to the transducer within the handle 88 is illustrated generally in FIG. 2.
- the coupling is a quick attachment-detachment system.
- An ultrasonic medical device with a quick attachment-detachment system is described in the Assignee's co-pending patent applications U.S. Ser. No. 09/975,725; U.S. Ser. No. 10/268,487 and U.S. Ser. No. 10/268,843, and the entirety of all these applications are hereby incorporated herein by reference.
- FIG. 3 shows an alternative embodiment of the ultrasonic probe 15 of the present invention.
- the diameter of the ultrasonic probe 15 is approximately uniform from the proximal end 31 of the ultrasonic probe 15 to the distal end 24 of the ultrasonic probe 15 .
- the ultrasonic probe 15 is a wire. In an embodiment of the present invention, the ultrasonic probe 15 is elongated. In an embodiment of the present invention, the diameter of the ultrasonic probe 15 changes at greater than two defined intervals. In an embodiment of the present invention, the transitions 82 of the ultrasonic probe 15 are tapered to gradually change the diameter from the proximal end 31 to the distal end 24 along the longitudinal axis of the ultrasonic probe 15 . In another embodiment of the present invention, the transitions 82 of the ultrasonic probe 15 are stepwise to change the diameter from the proximal end 31 to the distal end 24 along the longitudinal axis of the ultrasonic probe 15 . Those skilled in the art will recognize there can be any number of defined intervals and transitions, and the transitions can be of any shape known in the art and be within the spirit and scope of the present invention.
- the gradual change of the diameter from the proximal end 31 to the distal end 24 occurs over the at least one transition 82 , with each transition 82 having an approximately equal length.
- the gradual change of the diameter from the proximal end 31 to the distal end 24 occurs over a plurality of transitions 82 with each transition 82 having a varying length.
- the transition 82 refers to a section where the diameter varies from a first diameter to a second diameter.
- the ultrasonic probe 15 has a small diameter.
- the cross section of the ultrasonic probe is approximately circular.
- the diameter of the distal end 24 of the ultrasonic probe 15 is about 0.004 inches.
- the diameter of the distal end 24 of the ultrasonic probe 15 is about 0.015 inches.
- the diameter of the distal end 24 of the ultrasonic probe 15 varies between about 0.003 inches and about 0.025 inches.
- an ultrasonic probe 15 can have a diameter at the distal end 24 smaller than about 0.003 inches, larger than about 0.025 inches, and between about 0.003 inches and about 0.025 inches and be within the spirit and scope of the present invention.
- the diameter of the proximal end 31 of the ultrasonic probe 15 is about 0.012 inches. In another embodiment of the present invention, the diameter of the proximal end 31 of the ultrasonic probe 15 is about 0.025 inches. In other embodiments of the present invention, the diameter of the proximal end 31 of the ultrasonic probe 15 varies between about 0.003 inches and about 0.025 inches. Those skilled in the art will recognize the ultrasonic probe 15 can have a diameter at the proximal end 31 smaller than about 0.003 inches, larger than about 0.025 inches, and between about 0.003 inches and about 0.025 inches and be within the spirit and scope of the present invention.
- the probe tip 9 can be any shape including, but not limited to, rounded, bent, a ball or larger shapes. In a preferred embodiment of the present invention, the probe tip 9 is smooth to prevent damage to the deep veins 75 and the valves in the deep veins 75 . In one embodiment of the present invention, the ultrasonic energy source 99 is a physical part of the ultrasonic medical device 11 . In another embodiment of the present invention, the ultrasonic energy source 99 is not an integral part of the ultrasonic medical device 11 . The ultrasonic probe 15 is used to ablate a thrombus and may be disposed of after use.
- the ultrasonic probe 15 is for a single use and on a single patient., In a preferred embodiment of the present invention, the ultrasonic probe 15 is disposable. In another embodiment of the present invention, the ultrasonic probe 15 can be used multiple times.
- the ultrasonic probe 15 is designed, constructed and comprised of a material to not dampen the transverse ultrasonic vibration, and thereby supports a transverse vibration when flexed.
- the ultrasonic probe 15 comprises titanium or a titanium alloy.
- the ultrasonic probe 15 comprises titanium alloy Ti-6Al-4V.
- the elements comprising Ti-6Al-4V and the representative elemental weight percentages of Ti-6Al-4V are titanium (about 90%), aluminum (about 6%), vanadium (about 4%), iron (maximum about 0.25%) and oxygen (maximum about 0.2%).
- Titanium is a strong, flexible, low density, low radiopacity and easily fabricated metal that is used as a structural material. Titanium and its alloys have excellent corrosion resistance in many environments and have good elevated temperature properties.
- the ultrasonic probe 15 comprises stainless steel. In another embodiment of the present invention, the ultrasonic probe 15 comprises an alloy of stainless steel. In another embodiment of the present invention, the ultrasonic probe 15 comprises aluminum. In another embodiment of the present invention, the ultrasonic probe 15 comprises an alloy of aluminum. In another embodiment of the present invention, the ultrasonic probe 15 comprises a combination of titanium and stainless steel. Those skilled in the art will recognize that the ultrasonic probe can be comprised of many other materials known in the art and be within the spirit and scope of the present invention.
- the physical properties (i.e., length, cross sectional shape, dimensions, etc.) and material properties (i.e., yield strength, modulus, etc.) of the ultrasonic probe 15 are selected for operation of the ultrasonic probe 15 in the transverse mode.
- the length of the ultrasonic probe 15 of the present invention is chosen to be resonant in a transverse mode. In an embodiment of the present invention, the ultrasonic probe 15 is between about 30 centimeters and about 300 centimeters in length.
- an ultrasonic probe can have a length shorter than about 30 centimeters, a length longer than about 300 centimeters and a length between about 30 centimeters and about 300 centimeters and be within the spirit and scope of the present invention.
- the handle 88 surrounds the transducer located between the proximal end 31 of the ultrasonic probe 15 and the connector 93 .
- the transducer includes, but is not limited to, a horn, an electrode, an insulator, a backnut, a washer, a piezo microphone, and a piezo drive.
- the transducer converts electrical energy provided by the ultrasonic energy source 99 to mechanical energy and sets the operating frequency of the ultrasonic medical device 11 .
- the transducer is capable of engaging the ultrasonic probe 15 at the proximal end 31 with sufficient restraint to form an acoustical mass that can propagate the ultrasonic energy provided by the ultrasonic energy source 99 .
- FIG. 4 shows the main veins in the leg 74 including deep veins 75 , superficial veins 76 and short veins 77 .
- the deep veins 75 of the leg 74 pass through the center of the leg 74 and are surrounded by muscles.
- the superficial veins 76 of the leg 74 are located in a fatty layer underneath the skin.
- the short veins 77 of the leg 74 also known as connecting veins, link the deep veins 75 and the superficial veins 76 .
- the deep veins 75 of the leg 74 are important for the upward flow of blood to the heart.
- the deep veins 75 comprise one way valves that prevent the blood from flowing backward.
- the deep veins 75 lie deep within the muscle and carry most of the blood out of the leg 74 and to the heart for oxygenation.
- Muscles surrounding the deep veins 75 including the quadriceps, thigh muscles, gastrocnemius, soleus, abductors, peroneus muscles, plantaris muscles and popliteud muscles, compress the one way valves to help force the blood in an upward direction toward the heart.
- the deep veins 75 carry approximately ninety percent of the blood from the legs 74 to the heart.
- Various deep veins 75 in the leg 74 include, but are not limited to the common iliac, the femoral, the popliteal 71 and the tibial veins 72 .
- the deep veins generally follow the course of the associated arteries.
- the tibial veins 72 also known as the peroneal veins, are located in the calf.
- the anterior tibial veins 72 pass between the tibia and the fibula along the leg 74 .
- the anterior tibial veins 72 receive blood from the knee joint, muscles of the thigh, and upper calf and the join the posterior tibial vein 72 and the popliteal vein 71 .
- the popliteal vein 71 is formed by the junction of the anterior and posterior tibial veins 72 and ascends to the femoral vein.
- the popliteal vein 71 usually has four valves to assist with the transportation of blood.
- the superficial veins 76 of the leg 74 play a minor role in carrying the blood to the heart. While the superficial veins 76 comprise one way valves that are similar to those in the deep veins 75 , the one way valves in the superficial veins 76 are not surrounded by muscle. The superficial veins 76 lie above the muscles of the leg 74 . Because the one way valves in the superficial veins 76 are not surrounded by muscle, the flow of blood upward in the superficial veins 76 is much slower when compared to the blood flow in the deep veins 75 . A majority of the blood that flows up the superficial veins 76 is diverted into the deep veins 75 through the short veins 77 .
- Valves in the short veins 77 of the leg 74 allow the blood to flow from the superficial veins 76 to the deep veins 75 , but not vice versa.
- Various superficial veins 76 in the leg 74 include, but are not limited to, the great saphenous and the lesser saphenous veins.
- the deep veins 75 , the superficial veins 76 and the short veins 77 all have valves that allow blood to flow in one direction only, and prevent the blood from flowing back towards the capillaries and collecting or puddling in the lower leg.
- Disruption, inversion or damage to the valves can cause the blood to flow down the veins in the wrong direction and puddle in the lower leg.
- This disruption or damage to the valves causes the veins to enlarge (varicose veins) or cause pain, leg swelling, hypergigmentation and skin ulcers in the part of the leg 74 around the ankle.
- the valves in the veins are filamentous and composed of two leaflets that allow blood to flow in only one direction to prevent the blood from falling back into the leg after the leg muscles have helped to propel the blood toward the heart.
- the ultrasonic probe 15 of the present invention is atraumatic and does not damage, disrupt or invert the valves.
- the small diameter of the ultrasonic probe 15 allows the ultrasonic probe 15 to be transited through an opening in the valve without damaging the valve.
- the small diameter of the ultrasonic probe 15 allows the ultrasonic probe 15 to minimize contact with the valves as the ultrasonic probe 15 is fed through the deep vein 75 and valves.
- the combination of the flexibility of the ultrasonic probe 15 and the smooth probe tip 9 allows the ultrasonic probe 15 to be moved through the valve without perforating the membrane comprising the valve while maintaining the integrity of the valve.
- the flexibility of the ultrasonic probe 15 allows the ultrasonic probe 15 to be deflected, flexed and bent through the deep vein 75 and the valves.
- the smooth probe tip 9 also prevents damage, disruption or inversion of the valves upon retraction of the ultrasonic probe 15 from the deep vein 75 .
- FIG. 5 shows a thrombus 80 in the deep vein 75 of the leg 74 .
- the presence of the thrombus 80 , or blood clot, in the deep veins 75 of the leg presents a major risk to a patient. Since the blood from the deep veins travels to the heart and ultimately to the lungs, the thrombus 80 or at least a portion of the thrombus 80 in the deep veins 75 of the leg 74 can pass through the heart and obstruct the flow of blood to one or more arteries in the lungs, a condition known as pulmonary embolism. The degree of severity of the pulmonary embolism depends on the size of the thrombus 80 and the number of thrombi.
- a small thrombus 80 can block a small artery in the lungs, causing a small piece of lung tissue to die, a condition known as pulmonary infarction.
- a larger thrombus 80 presents a life threatening condition since the larger thrombus 80 can obstruct all or at least a majority of the blood travelling from the right side of the heart to the lungs, thereby causing a quick death. Therefore, removal of the thrombus 80 to treat deep vein thrombosis is critical to the well being of the patient.
- FIG. 6 shows the ultrasonic probe 15 inserted in the deep vein 75 of the leg 74 being moved toward the thrombus 80 .
- the ultrasonic probe 15 has a stiffness that gives the ultrasonic probe 15 a flexibility allowing the ultrasonic probe 15 to be deflected, flexed and bent through the tortuous paths of the vasculature, including the deep vein 75 .
- the ultrasonic probe 15 can be bent, flexed and deflected to reach the thrombus 80 in the deep veins 75 of the leg 74 that would otherwise be difficult to reach.
- FIG. 7 shows an enlarged view of a portion of the longitudinal axis of the ultrasonic probe 15 in communication with the thrombus 80 in the deep vein 75 of the leg 74 .
- the ultrasonic energy source 99 is activated to provide a low power electric signal of between about 2 watts to about 6 watts to the transducer that is located within the handle 88 .
- the transducer converts electrical energy provided by the ultrasonic energy source 99 to mechanical energy.
- the operating frequency of the ultrasonic medical device 11 is set by the transducer and the ultrasonic energy source 99 finds the resonant frequency of the transducer through a Phase Lock Loop.
- the horn creates a longitudinal wave along at least a portion of the longitudinal axis of the ultrasonic probe 15 .
- the longitudinal wave is converted to a transverse wave along at least a portion of the longitudinal axis of the ultrasonic probe 15 through a nonlinear dynamic buckling of the ultrasonic probe 15 .
- a transverse ultrasonic vibration is created along the longitudinal axis of the ultrasonic probe 15 .
- the ultrasonic probe 15 is vibrated in a transverse mode of vibration.
- the transverse mode of vibration of the ultrasonic probe 15 differs from an axial (or longitudinal) mode of vibration disclosed in the prior art.
- the transverse ultrasonic vibrations along the longitudinal axis of the ultrasonic probe 15 create a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of the ultrasonic probe 15 .
- FIG. 8 shows the ultrasonic probe 15 of the present invention having a plurality of transverse nodes 40 and a plurality of transverse anti-nodes 42 along a portion of the longitudinal axis of the ultrasonic probe 15 and in communication with the thrombus 80 .
- the transverse nodes 40 are areas of minimum energy and minimum vibration.
- the transverse anti-nodes 42 or areas of maximum energy and maximum vibration, also occur at repeating intervals along the portion of the longitudinal axis of the ultrasonic probe 15 .
- the number of transverse nodes 40 and transverse anti-nodes 42 , and the spacing of the transverse nodes 40 and transverse anti-nodes 42 of the ultrasonic probe 15 depend on the frequency of energy produced by the ultrasonic energy source 99 .
- the separation of the transverse nodes 40 and transverse anti-nodes 42 is a function of the frequency, and can be affected by tuning the ultrasonic probe 15 .
- the transverse anti-nodes 42 will be found at a position exactly one half of the distance between the transverse nodes 40 located adjacent to each side of the transverse anti-nodes 42 .
- the transverse wave is transmitted along the longitudinal axis of the ultrasonic probe 15 and the interaction of the surface of the ultrasonic probe 15 with the medium surrounding the ultrasonic probe 15 creates an acoustic wave in the surrounding medium.
- the transverse wave is transmitted along the longitudinal axis of the ultrasonic probe 15 , the ultrasonic probe 15 vibrates transversely.
- the transverse motion of the ultrasonic probe 15 produces cavitation in the medium surrounding the ultrasonic probe 15 to ablate the thrombus 80 .
- Cavitation is a process in which small voids are formed in a surrounding medium through the rapid motion of the ultrasonic probe 15 and the voids are subsequently forced to compress.
- the compression of the voids creates a wave of acoustic energy which acts to dissolve the matrix binding the thrombus 80 , while having no damaging effects on healthy tissue.
- Action of the ultrasonic probe 15 results in fibrinolysis and surface erosion of the thrombus 80 .
- the thrombus 80 in the deep vein 75 is resolved into a particulate having a size on the order of red blood cells (approximately 5 microns in diameter).
- the size of the particulate is such that the particulate is easily discharged from the body through conventional methods or simply dissolves into the blood stream.
- a conventional method of discharging the particulate from the body includes transferring the particulate through the blood stream to the kidney where the particulate is excreted as bodily waste.
- the particulate By resolving the thrombus 80 in the deep vein 75 to a particulate, the particulate will travel with the blood to the heart and ultimately to the arteries of the lungs without any risk of obstructing the arteries and causing a pulmonary embolism or a pulmonary infarction.
- the transverse ultrasonic vibration of the ultrasonic probe 15 results in a portion of the longitudinal axis of the ultrasonic probe 15 vibrated in a direction not parallel to the longitudinal axis of the ultrasonic probe 15 .
- the transverse vibration results in movement of the longitudinal axis of the ultrasonic probe 15 in a direction approximately perpendicular to the longitudinal axis of the ultrasonic probe 15 .
- Transversely vibrating ultrasonic probes for biological material ablation are described in the Assignee's U.S. Pat. No. 6,551,337; U.S. Pat. No. 6,652,547; and U.S. Pat. No. 6,660,013 and Assignee's co-pending patent application U.S. Ser. No. 09/917,471, which further describe the design parameters for such an ultrasonic probe and its use in ultrasonic devices for ablation, and the entirety of these patents and patent applications are hereby incorporated herein by reference.
- the thrombus destroying effects of the ultrasonic medical device 11 are not limited to those regions of the ultrasonic probe 15 that may come into contact with the thrombus 80 . Rather, as a section of the longitudinal axis of the ultrasonic probe 15 is positioned in proximity to the thrombus 80 , the thrombus 80 is removed in all areas adjacent to the plurality of energetic transverse nodes 40 and transverse anti-nodes 42 that are produced along the portion of the length of the longitudinal axis of the ultrasonic probe 15 , typically in a region having a radius of up to about 6 mm around the ultrasonic probe 15 .
- a novel feature of the present invention is the ability to utilize ultrasonic probes 15 of extremely small diameter compared to prior art probes, without loss of efficiency, because the thrombus fragmentation process is not dependent on the area of the probe tip 9 .
- Highly flexible ultrasonic probes 15 can therefore be designed to mimic device shapes that enable facile insertion into thrombus areas or extremely narrow interstices that contain the thrombus 80 .
- Another advantage provided by the present invention is the ability to rapidly move the thrombus 80 from large areas within cylindrical or tubular surfaces.
- the number of transverse nodes 40 and transverse anti-nodes 42 occurring along the longitudinal axis of the ultrasonic probe 15 is modulated by changing the frequency of energy supplied by the ultrasonic energy source 99 .
- the exact frequency, however, is not critical and the ultrasonic energy source 99 run at, for example, about 20 kHz is sufficient to create an effective number of thrombus destroying transverse anti-nodes 42 along the longitudinal axis of the ultrasonic probe 15 .
- the low frequency requirement of the present invention is a further advantage in that the low frequency requirement leads to less damage to healthy tissue.
- the ultrasonic probe 15 including diameter, length and distance to the ultrasonic energy source 99 , in order to affect the number and spacing of the transverse nodes 40 and transverse anti-nodes 42 along a portion of the longitudinal axis of the ultrasonic probe 15 .
- the present invention allows the use of ultrasonic energy to be applied to the thrombus 80 selectively, because the ultrasonic probe 15 conducts energy across a frequency range from about 10 kHz through about 100 kHz.
- the amount of ultrasonic energy to be applied to a particular treatment site is a function of the amplitude and frequency of vibration of the ultrasonic probe 15 .
- the amplitude or throw rate of the energy is in the range of about 25 microns to about 250 microns, and the frequency in the range of about 10 kHz to about 100 kHz.
- the frequency of ultrasonic energy is from about 20 kHz to about 35 kHz.
- the present invention also provides a method of preventing deep vein thrombosis.
- a medical professional gains access to the deep vein 75 in the leg 74 through an insertion point in the deep vein 75 .
- a device including, but not limited to, a vascular introducer can be used to create an insertion point in the deep vein 75 to gain access to the deep vein 75 .
- a vascular introducer for use with an ultrasonic probe is described in Assignee's co-pending patent application U.S. Ser. No. 10/080,787, and the entirety of this application is hereby incorporated herein by reference.
- the ultrasonic probe 15 After gaining access to the deep vein 75 in the leg 74 , the ultrasonic probe 15 is moved through the insertion point of the deep vein 75 , navigated through the deep vein 75 and placed adjacent to the thrombus 80 .
- the ultrasonic probe 15 is inserted in the deep vein 75 below the thrombus 80 and navigated upward with the flow of blood in the deep vein 75 toward the thrombus 80 . Less force is required in moving the ultrasonic probe 15 with the flow of blood because there is less friction and viscous drag.
- the ultrasonic probe 15 is inserted in the deep vein above the thrombus 80 and navigated downward against the flow of blood in the deep vein 75 toward the thrombus 80 . While a greater force is required to navigate the ultrasonic probe 15 against the flow of blood, the strength of the ultrasonic probe 15 permits movement against the flow of blood. Whether the ultrasonic probe 15 enters above or below the thrombus 80 is often dictated by anatomical considerations of the patient.
- the ultrasonic probe 15 is placed in communication with the thrombus 80 by sweeping, twisting or rotating the ultrasonic probe 15 along the thrombus 80 .
- the ultrasonic probe can be placed in communication with the thrombus in many ways known in the art and be within the spirit and scope of the present invention.
- the ultrasonic probe 15 is placed in communication with the thrombus 80 and the ultrasonic energy source 99 engaged to the ultrasonic probe 15 is activated to generate a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the ultrasonic probe 15 .
- the ultrasonic probe may then be swept, twisted or rotated along the thrombus 80 .
- the transverse ultrasonic vibration creates a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of the ultrasonic probe 15 , causing a thrombus destroying effect along the portion of the length of the longitudinal axis of the ultrasonic probe 15 .
- the present invention also is a method of ablating the thrombus 80 in the deep vein 75 of the body.
- Access to the deep vein 75 in the leg 74 is gained by creating an insertion point in the deep vein 75 using a device such as a vascular introducer.
- the ultrasonic probe 15 having the proximal end 31 , the distal end 24 terminating in the probe tip 9 and a longitudinal axis between the proximal end and the distal end 24 is inserted through the insertion point of the deep vein 75 and moved through the deep vein 75 and placed in communication with the thrombus 80 .
- a stiffness of the ultrasonic probe 15 of the ultrasonic medical device 11 gives the ultrasonic probe 15 a flexibility allowing the ultrasonic probe 15 to be deflected, flexed and bent through the tortuous paths of the vasculature, including the deep vein 75 .
- the ultrasonic energy source 99 engaged to the ultrasonic probe 15 is activated to produce an electric signal to drive the transducer of the ultrasonic medical device 11 to produce a transverse vibration of the ultrasonic probe 15 .
- the transverse ultrasonic vibration of the ultrasonic probe 15 produces cavitation in a medium surrounding a portion of the length of the longitudinal axis of the ultrasonic probe 15 to ablate the thrombus 80 .
- a method of resolving deep vein thrombosis comprising providing an ultrasonic medical device 11 comprising an ultrasonic probe 15 having a proximal end 31 , a distal end 24 and a longitudinal axis therebetween; navigating the ultrasonic probe 15 proximal to a thrombus 80 ; placing the ultrasonic probe 15 in communication with the thrombus 80 ; activating an ultrasonic energy source 99 engaged to the ultrasonic probe 15 to generate a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the ultrasonic probe 15 , wherein the transverse vibration creates a plurality of transverse nodes 40 and a plurality of transverse anti-nodes 42 along a portion of the longitudinal axis of the ultrasonic probe 15 .
- a method of ablating a thrombus 80 in a deep vein 75 of a body comprising providing an ultrasonic medical device 11 comprising an ultrasonic probe 15 having a proximal end 31 , a distal end 24 terminating in a probe tip 9 , and a longitudinal axis between the proximal end 31 and the distal end 24 ; inserting the ultrasonic probe 15 in an insertion point of the deep vein 75 ; moving the ultrasonic probe 15 to place the ultrasonic probe 15 in communication with the thrombus 80 ; activating an ultrasonic energy source 99 engaged to the ultrasonic probe 15 to produce an electric signal that drives a transducer of the ultrasonic medical device 11 to produce a transverse ultrasonic vibration of the ultrasonic probe 15 , wherein the transverse ultrasonic vibration produces cavitation in a medium surrounding the ultrasonic probe 15 to ablate the thrombus 80 .
- the ultrasonic probe 15 is vibrated in a torsional mode.
- a portion of the longitudinal axis of the ultrasonic probe 15 comprises a radially asymmetric cross section and the length of the ultrasonic probe 15 is chosen to be resonant in the torsional mode.
- a transducer transmits ultrasonic energy received from the ultrasonic energy source 99 to the ultrasonic probe 15 , causing the ultrasonic probe 15 to vibrate torsionally.
- the ultrasonic energy source 99 produces the electrical energy that is used to produce a torsional vibration along the longitudinal axis of the ultrasonic probe 15 .
- the torsional vibration is a torsional oscillation whereby equally spaced points along the longitudinal axis of the ultrasonic probe 15 including the probe tip 9 vibrate back and forth in a short arc about the longitudinal axis of the ultrasonic probe 15 .
- a section proximal to each of a plurality of torsional nodes and a section distal to each of the plurality of torsional nodes are vibrated out of phase, with the proximal section vibrated in a clockwise direction and the distal section vibrated in a counterclockwise direction, or vice versa.
- the torsional vibration results in an ultrasonic energy transfer to the biological material with minimal loss of ultrasonic energy that could limit the effectiveness of the ultrasonic medical device 11 .
- the torsional vibration produces a rotation and a counterrotation along the longitudinal axis of the ultrasonic probe 15 that creates the plurality of torsional nodes and a plurality of torsional anti-nodes along a portion of the longitudinal axis of the ultrasonic probe 15 resulting in cavitation along the portion of the longitudinal axis of the ultrasonic probe 15 comprising the radially asymmetric cross section in a medium surrounding the ultrasonic probe 15 that ablates the biological material.
- the ultrasonic probe 15 is vibrated in a torsional mode and a transverse mode.
- a transducer transmits ultrasonic energy from the ultrasonic energy source 99 to the ultrasonic probe 15 , creating a torsional vibration of the ultrasonic probe 15 .
- the torsional vibration induces a transverse vibration along an active area of the ultrasonic probe 15 , creating a plurality of nodes and a plurality of anti-nodes along the active area that result in cavitation in a medium surrounding the ultrasonic probe 15 .
- the active area of the ultrasonic probe 15 undergoes both the torsional vibration and the transverse vibration.
- the transverse vibration is excited by the torsional vibration. Coupling of the torsional mode of vibration and the transverse mode of vibration is possible because of common shear components for the elastic forces. The transverse vibration is induced when the frequency of the transducer is close to a transverse resonant frequency of the ultrasonic probe 15 . The combination of the torsional mode of vibration and the transverse mode of vibration is possible because for each torsional mode of vibration, there are many close transverse modes of vibration.
- the transverse vibration is tuned into coincidence with the torsional vibration.
- the bending causes a shift in frequency due to changes in tension.
- the active area of the ultrasonic probe 15 is vibrated in a direction not parallel to the longitudinal axis of the ultrasonic probe 15 while equally spaced points along the longitudinal axis of the ultrasonic probe 15 in a proximal section vibrate back and forth in a short arc about the longitudinal axis of the ultrasonic probe 15 .
- the present invention can also be used for the arterial removal of the thrombus 80 .
- the ultrasonic probe 15 of the present invention can not only be used in the deep veins of the leg for venous removal of thrombus 80 , but the ultrasonic probe 15 can also be adapted for use in the arteries of the leg for arterial removal of thrombus 80 .
- the present invention provides and apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis.
- An ultrasonic probe is used to ablate a thrombus in a deep vein of the leg, preventing the thrombus, or a portion of the thrombus, from being carried with the blood to the heart and obstructing the flow of blood to one or more arteries in the lungs.
- the present invention provides an ultrasonic medical device to treat deep vein thrombosis that is simple, user-friendly, time efficient, reliable and cost effective.
Abstract
Description
- This application is a continuation-in-part of application Ser. No. 10/665,445, filed Sep. 19, 2003, which is a continuation of application Ser. No. 09/776,015, filed Feb. 2, 2001, now U.S. Pat. No. 6,652,547, which is a continuation-in-part of application Ser. No. 09/618,352, filed Jul. 19, 2000, now U.S. Pat. No. 6,551,337, which claims benefit of Provisional Application Serial No. 60/178,901, filed Jan. 28, 2000, and claims benefit of Provisional Application Serial No. 60/157,824, filed Oct. 5, 1999, the entirety of all these applications are hereby incorporated herein by reference.
- The present invention relates to medical devices, and more importantly to an apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis.
- The formation of a blood clot or a thrombus in a deep vein of a body, a condition known as deep vein thrombosis (DVT), presents many problems to the individual suffering from the condition. The blood clot or thrombus can lead to various complications, including decreased blood flow and death. The thrombus in the deep vein interferes with blood circulation in the area of the thrombus and can break away and travel in the vein, ultimately blocking a blood vessel in the lungs, brain, heart or other critical areas of the body, a condition known as pulmonary embolism (PE). DVT can also damage the valves in the vein by inhibiting upward flow of blood, causing the blood to pool in the leg. DVT most commonly occurs in the lower leg, upper leg and thigh area.
- DVT is a condition characterized by a reduction in blood flow, with several factors increasing the susceptibility of developing DVT. A person who has had a previous DVT condition is more likely to have a subsequent DVT condition. Immobility, such as prolonged sitting, long travel, surgical procedures or the subsequent bed rest recovery from a surgical procedure, increases the probability of developing DVT. The probability of a DVT condition is increased by pregnancy, childbirth and the use of medications such as estrogen and birth control pills. People undergoing cancer treatments or having a history of polycythemia vera, malignant tumors and inherited or acquired hypercoagulability have a higher probability of developing DVT. The incidence of DVT is more common in people over 40 years of age in addition to individuals who are obese.
- Many scientific studies have analyzed DVT. A study of passengers who took a long haul flights over a six week period was performed by New Zealand researchers. Subjects traveled for at least ten hours per flight and each subject flew an average of about thirty-nine hours over the study. The results of the study showed that nine of the nearly nine hundred passengers developed a blood clot. (Hughes et al., (Dec. 20, 2003)The Lancet, 362: 2039-2044). In a separate case, a twenty-eight year old female British passenger on a twenty hour flight from Australia to London died as a result of the DVT condition. A separate study in the United Kingdom found that approximately one in two thousand people develop DVT per year.
- The prior art has discussed various ways of preventing and treating DVT and pulmonary embolism. Prior art attempts to prevent and treat DVT have used intermittent pressure on a leg of a patient to help blood circulation. Through the application of intermittent pressure to the leg, blood flow is directed through the leg and into the torso.
- U.S. Pat. No. 6,615,080 to Unsworth et al. discloses a single channel neuromuscular electrical stimulation device for the prevention of deep vein thrombosis, pulmonary embolism, lower extremity edema and other associated conditions by electrical stimulation of the muscles of the foot. Surface electrodes positioned over the foot muscles are attached to a stimulator that stimulates the foot muscles to reduce pooling of the blood in the soleal veins of the calf. The Unsworth et al. disclosure is limited to the soleal veins of the calf. The Unsworth et al. device does not engage the area of the blood clot or thrombus, but rather relies on electrical stimulation of the muscles to prevent DVT, pulmonary embolism and lower extremity edema.
- U.S. Pat. No. 6,290,662 to Morris et al. discloses an apparatus for deep vein thrombosis prophylaxis and other conditions comprising an inflatable/deflatable bladder disposed against an extremity such as the upper calf, foot or hand of a patient. An inelastic member of the Morris et al. device fully encloses the bladder and body part while compressive forces are directed against the body part when the bladder expands. The Morris et al. device does not directly engage the area of the blood clot or thrombus, but relies on the compressive forces to increase blood circulation and translate to the problematic area of the blood clot or thrombus. The Morris et al. device relies on a range of pressures that may be too high or too low depending on the patient and may not directly translate to increased blood flow.
- The prior art does not provide a solution for preventing and treating deep vein thrombosis in a safe, effective and time efficient manner. The prior art does not provide a solution for engaging the blood clot or the thrombus. Prior art instruments are limited in that they rely upon electrical stimulation of the muscles and transmission of the electrical simulation to the area of the blood clot or thrombus. Prior art instruments use high compressive forces to attempt to increase blood circulation. Therefore, there remains a need in the art for an apparatus and a method for an apparatus and a method of preventing and treating deep vein thrombosis that engages the blood clot or thrombus while not compromising the health of the patient.
- The present invention provides an apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis. The present invention is an ultrasonic medical device comprising a flexible, ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween. The ultrasonic medical device includes a transducer for creating a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the flexible, ultrasonic probe. A coupling engages the proximal end of the flexible, ultrasonic probe to a distal end of the transducer. An ultrasonic energy source engaged to the transducer produces an ultrasonic energy. The transverse ultrasonic vibration generates a plurality of transverse nodes and a plurality of transverse anti-nodes along at least a portion of the longitudinal axis of the flexible, ultrasonic probe, creating cavitation in a medium surrounding the flexible, ultrasonic probe to ablate a thrombus and treat deep vein thrombosis.
- The present invention is an ultrasonic medical device for treating deep vein thrombosis comprising an ultrasonic probe having a proximal end, a distal end terminating in a probe tip and a longitudinal axis between the proximal end and the distal end. The ultrasonic medical device includes a transducer that converts electrical energy into mechanical energy, creating a transverse ultrasonic vibration along the longitudinal axis of the ultrasonic probe. A coupling engages the proximal end of the ultrasonic probe to the distal end of the transducer. The transverse ultrasonic vibration produces a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of the ultrasonic probe.
- The present invention is a method of resolving deep vein thrombosis comprising: providing an ultrasonic medical device comprising an ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween; navigating the ultrasonic probe adjacent to a thrombus; placing the ultrasonic probe in communication with the thrombus; and activating an ultrasonic energy source engaged to the ultrasonic probe to generate a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the ultrasonic probe, wherein the transverse ultrasonic vibration creates a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of the ultrasonic probe.
- The present invention is a method of ablating a thrombus in a deep vein of a body comprising providing an ultrasonic medical device comprising an ultrasonic probe having a proximal end, a distal end terminating in a probe tip and a longitudinal axis between the proximal end and the distal end. The ultrasonic probe is inserted into an insertion point in the deep vein and moved to place the ultrasonic probe in communication with the thrombus. An ultrasonic energy source engaged to the ultrasonic probe is activated to produce an electric signal to drive a transducer of the ultrasonic medical device to generate a transverse ultrasonic vibration of the ultrasonic probe. The transverse ultrasonic vibration produces cavitation in a medium surrounding the ultrasonic probe to ablate the thrombus.
- The present invention provides an apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis. An ultrasonic probe is used to ablate a thrombus in a deep vein of the leg, preventing the thrombus, or a portion of the thrombus, from being carried with the blood to the heart and obstructing the flow of blood to one or more arteries in the lungs. The present invention provides an ultrasonic medical device that is simple, user-friendly, time efficient, reliable and cost effective.
- The present invention will be further explained with reference to the attached drawings, wherein like structures are referred to by like numerals throughout the several views. The drawings shown are not necessarily to scale, with emphasis instead generally being placed upon illustrating the principles of the present invention.
- FIG. 1A is a side plan view of an ultrasonic probe of the present invention inserted into a tibial deep vein of a leg where the probe is moving toward a thrombus in the tibial vein.
- FIG. 1B is a side plan view of an ultrasonic probe of the present invention inserted into a popliteal deep vein of a leg where the probe is moving toward a thrombus in the popliteal vein.
- FIG. 2 is a side plan view of an ultrasonic medical device of the present invention capable of ablating a thrombus to treat deep vein thrombosis.
- FIG. 3 is a side plan view of an ultrasonic probe of the present invention having an approximately uniform diameter from a proximal end of the ultrasonic probe to the distal end of the ultrasonic probe.
- FIG. 4 is a view of a leg of a patient with deep veins, superficial veins and short veins.
- FIG. 5 is a view of a thrombus in a deep vein of a leg of a patient.
- FIG. 6 is a perspective view of an ultrasonic probe of the present invention inserted in a deep vein of a leg and being moved toward a thrombus in the deep vein.
- FIG. 7 is an enlarged view of an ultrasonic probe of the present invention in communication with a thrombus in a deep vein of a body.
- FIG. 8 is a view of an ultrasonic probe of the present invention showing a plurality of transverse nodes and a plurality of transverse anti-nodes while in communication with a thrombus in a deep vein of a body.
- While the above-identified drawings set forth preferred embodiments of the present invention, other embodiments of the present invention are also contemplated, as noted in the discussion. This disclosure presents illustrative embodiments of the present invention by way of representation and not limitation. Numerous other modifications and embodiments can be devised by those skilled in the art which fall within the scope and spirit of the principles of the present invention.
- The present invention provides an apparatus and a method for using an ultrasonic medical device to ablate a thrombus to treat deep vein thrombosis. The ultrasonic medical device comprises an ultrasonic probe, a transducer, a coupling engaging a proximal end of the ultrasonic probe to a distal end of the transducer and an ultrasonic energy source engaged to the transducer. The ultrasonic probe is inserted into a deep vein and placed in communication with the thrombus. The ultrasonic energy source produces an ultrasonic energy that is transmitted to the transducer, where the transducer creates a transverse ultrasonic vibration along the ultrasonic probe. The transverse ultrasonic vibration creates a plurality of transverse nodes and a plurality of transverse anti-nodes along the longitudinal axis of the ultrasonic probe, creating cavitation along a portion of the longitudinal axis of the ultrasonic probe to ablate the thrombus and treat deep vein thrombosis. By ablating the thrombus in the deep vein, the thrombus or a portion of the thrombus is not carried with the blood to the heart or the arteries of the lungs where a pulmonary embolism can occur.
- The following terms and definitions are used herein:
- “Ablate” as used herein refers to removing, clearing, destroying or taking away a thrombus. “Ablation” as used herein refers to a removal, clearance, destruction, or taking away of the thrombus.
- “Anti-node” as used herein refers to a region of a maximum energy emitted by an ultrasonic probe at or proximal to a specific location along a longitudinal axis of the ultrasonic probe.
- “Node” as used herein refers to a region of a minimum energy emitted by an ultrasonic probe at or proximal to a specific location along a longitudinal axis of the ultrasonic probe.
- “Probe” as used herein refers to a device capable of propagating an energy emitted by the ultrasonic energy source along a longitudinal axis of the probe, resolving the energy into an effective cavitational energy at a specific resonance (defined by a plurality of nodes and a plurality of anti-nodes along an “active area” of the probe) and is capable of an acoustic impedance transformation of electrical energy to a mechanical energy.
- “Thrombus” as used herein refers to a collection of a matter including, but not limited to, a group of similar cells, intravascular blood clots, occlusions, plaque, biological material, fibrin, calcified plaque, calcium deposits, occlusional deposits, atherosclerotic plaque, fatty deposits, adipose tissues, atherosclerotic cholesterol buildup, fibrous material buildup, arterial stenoses, minerals, high water content tissues, platelets, cellular debris, wastes and other occlusive materials.
- “Transverse” as used herein refers to a vibration of a probe not parallel to a longitudinal axis of the probe. A “transverse wave” as used herein is a wave propagated along the probe in which a direction of a disturbance at a plurality of points of a medium is not parallel to a wave vector.
- An ultrasonic probe of an ultrasonic medical device of the present invention capable of ablating a
thrombus 80 to treat deep vein thrombus is illustrated generally at 15 in FIG. 1A and FIG. 1B. FIG. 1A shows theultrasonic probe 15 inserted at a lower calf of aleg 74 into adeep vein 75 of theleg 74 and adjacent to thethrombus 80 in thedeep vein 75. In FIG. 1A, theultrasonic probe 15 is inserted into apopliteal vein 72 in the lower calf area of theleg 74. A flexibility of the ultrasonic probe allows theultrasonic probe 15 to be navigated within thedeep vein 75. - FIG. 1B shows the
ultrasonic probe 15 inserted at a calf area into thedeep vein 75 of theleg 74 and adjacent to thethrombus 80 in thedeep vein 75. In FIG. 1B, theultrasonic probe 15 is inserted into thetibial vein 72. - FIG. 2 shows an ultrasonic medical device capable of ablating a thrombus to treat deep vein thrombosis and prevent the thrombus from obstructing a vasculature in the body. In a preferred embodiment of the present invention, the
ultrasonic probe 15 is used to ablate a thrombus in a deep vein of a leg or a deep vein of a pelvis. The ultrasonicmedical device 11 includes anultrasonic probe 15 which is coupled to an ultrasonic energy source orgenerator 99 for the production of an ultrasonic energy. A handle, 88, comprising aproximal end 87 and adistal end 86, surrounds a transducer within thehandle 88. The transducer, having a proximal end engaging theultrasonic energy source 99 and a distal end coupled to aproximal end 31 of theultrasonic probe 15, transmits the ultrasonic energy to theultrasonic probe 15. Aconnector 93 and a connectingwire 98 engage theultrasonic energy source 99 to the transducer. Theultrasonic probe 15 includes theproximal end 31, adistal end 24 that ends in aprobe tip 9 and a longitudinal axis between theproximal end 31 and thedistal end 24. In a preferred embodiment of the present invention shown in FIG. 2, a diameter of the ultrasonic probe decreases from a first definedinterval 26 to a second definedinterval 28 along the longitudinal axis of theultrasonic probe 15 over atransition 82. Acoupling 33 that engages theproximal end 31 of theultrasonic probe 15 to the transducer within thehandle 88 is illustrated generally in FIG. 2. In a preferred embodiment of the present invention, the coupling is a quick attachment-detachment system. An ultrasonic medical device with a quick attachment-detachment system is described in the Assignee's co-pending patent applications U.S. Ser. No. 09/975,725; U.S. Ser. No. 10/268,487 and U.S. Ser. No. 10/268,843, and the entirety of all these applications are hereby incorporated herein by reference. - FIG. 3 shows an alternative embodiment of the
ultrasonic probe 15 of the present invention. In the embodiment of the present invention shown in FIG. 3, the diameter of theultrasonic probe 15 is approximately uniform from theproximal end 31 of theultrasonic probe 15 to thedistal end 24 of theultrasonic probe 15. - In a preferred embodiment of the present invention, the
ultrasonic probe 15 is a wire. In an embodiment of the present invention, theultrasonic probe 15 is elongated. In an embodiment of the present invention, the diameter of theultrasonic probe 15 changes at greater than two defined intervals. In an embodiment of the present invention, thetransitions 82 of theultrasonic probe 15 are tapered to gradually change the diameter from theproximal end 31 to thedistal end 24 along the longitudinal axis of theultrasonic probe 15. In another embodiment of the present invention, thetransitions 82 of theultrasonic probe 15 are stepwise to change the diameter from theproximal end 31 to thedistal end 24 along the longitudinal axis of theultrasonic probe 15. Those skilled in the art will recognize there can be any number of defined intervals and transitions, and the transitions can be of any shape known in the art and be within the spirit and scope of the present invention. - In an embodiment of the present invention, the gradual change of the diameter from the
proximal end 31 to thedistal end 24 occurs over the at least onetransition 82, with eachtransition 82 having an approximately equal length. In another embodiment of the present invention, the gradual change of the diameter from theproximal end 31 to thedistal end 24 occurs over a plurality oftransitions 82 with eachtransition 82 having a varying length. Thetransition 82 refers to a section where the diameter varies from a first diameter to a second diameter. - In a preferred embodiment of the present invention, the
ultrasonic probe 15 has a small diameter. In a preferred embodiment of the present invention, the cross section of the ultrasonic probe is approximately circular. In an embodiment of the present invention, the diameter of thedistal end 24 of theultrasonic probe 15 is about 0.004 inches. In another embodiment of the present invention, the diameter of thedistal end 24 of theultrasonic probe 15 is about 0.015 inches. In other embodiments of the present invention, the diameter of thedistal end 24 of theultrasonic probe 15 varies between about 0.003 inches and about 0.025 inches. Those skilled in the art will recognize anultrasonic probe 15 can have a diameter at thedistal end 24 smaller than about 0.003 inches, larger than about 0.025 inches, and between about 0.003 inches and about 0.025 inches and be within the spirit and scope of the present invention. - In an embodiment of the present invention, the diameter of the
proximal end 31 of theultrasonic probe 15 is about 0.012 inches. In another embodiment of the present invention, the diameter of theproximal end 31 of theultrasonic probe 15 is about 0.025 inches. In other embodiments of the present invention, the diameter of theproximal end 31 of theultrasonic probe 15 varies between about 0.003 inches and about 0.025 inches. Those skilled in the art will recognize theultrasonic probe 15 can have a diameter at theproximal end 31 smaller than about 0.003 inches, larger than about 0.025 inches, and between about 0.003 inches and about 0.025 inches and be within the spirit and scope of the present invention. - The
probe tip 9 can be any shape including, but not limited to, rounded, bent, a ball or larger shapes. In a preferred embodiment of the present invention, theprobe tip 9 is smooth to prevent damage to thedeep veins 75 and the valves in thedeep veins 75. In one embodiment of the present invention, theultrasonic energy source 99 is a physical part of the ultrasonicmedical device 11. In another embodiment of the present invention, theultrasonic energy source 99 is not an integral part of the ultrasonicmedical device 11. Theultrasonic probe 15 is used to ablate a thrombus and may be disposed of after use. In a preferred embodiment of the present invention, theultrasonic probe 15 is for a single use and on a single patient., In a preferred embodiment of the present invention, theultrasonic probe 15 is disposable. In another embodiment of the present invention, theultrasonic probe 15 can be used multiple times. - The
ultrasonic probe 15 is designed, constructed and comprised of a material to not dampen the transverse ultrasonic vibration, and thereby supports a transverse vibration when flexed. In a preferred embodiment of the present invention, theultrasonic probe 15 comprises titanium or a titanium alloy. In a preferred embodiment of the present invention, theultrasonic probe 15 comprises titanium alloy Ti-6Al-4V. The elements comprising Ti-6Al-4V and the representative elemental weight percentages of Ti-6Al-4V are titanium (about 90%), aluminum (about 6%), vanadium (about 4%), iron (maximum about 0.25%) and oxygen (maximum about 0.2%). Titanium is a strong, flexible, low density, low radiopacity and easily fabricated metal that is used as a structural material. Titanium and its alloys have excellent corrosion resistance in many environments and have good elevated temperature properties. In another embodiment of the present invention, theultrasonic probe 15 comprises stainless steel. In another embodiment of the present invention, theultrasonic probe 15 comprises an alloy of stainless steel. In another embodiment of the present invention, theultrasonic probe 15 comprises aluminum. In another embodiment of the present invention, theultrasonic probe 15 comprises an alloy of aluminum. In another embodiment of the present invention, theultrasonic probe 15 comprises a combination of titanium and stainless steel. Those skilled in the art will recognize that the ultrasonic probe can be comprised of many other materials known in the art and be within the spirit and scope of the present invention. - The physical properties (i.e., length, cross sectional shape, dimensions, etc.) and material properties (i.e., yield strength, modulus, etc.) of the
ultrasonic probe 15 are selected for operation of theultrasonic probe 15 in the transverse mode. The length of theultrasonic probe 15 of the present invention is chosen to be resonant in a transverse mode. In an embodiment of the present invention, theultrasonic probe 15 is between about 30 centimeters and about 300 centimeters in length. Those skilled in the art will recognize an ultrasonic probe can have a length shorter than about 30 centimeters, a length longer than about 300 centimeters and a length between about 30 centimeters and about 300 centimeters and be within the spirit and scope of the present invention. - The
handle 88 surrounds the transducer located between theproximal end 31 of theultrasonic probe 15 and theconnector 93. In a preferred embodiment of the present invention, the transducer includes, but is not limited to, a horn, an electrode, an insulator, a backnut, a washer, a piezo microphone, and a piezo drive. The transducer converts electrical energy provided by theultrasonic energy source 99 to mechanical energy and sets the operating frequency of the ultrasonicmedical device 11. The transducer is capable of engaging theultrasonic probe 15 at theproximal end 31 with sufficient restraint to form an acoustical mass that can propagate the ultrasonic energy provided by theultrasonic energy source 99. - FIG. 4 shows the main veins in the
leg 74 includingdeep veins 75,superficial veins 76 and short veins 77. Thedeep veins 75 of theleg 74 pass through the center of theleg 74 and are surrounded by muscles. Thesuperficial veins 76 of theleg 74 are located in a fatty layer underneath the skin. The short veins 77 of theleg 74, also known as connecting veins, link thedeep veins 75 and thesuperficial veins 76. - The
deep veins 75 of theleg 74 are important for the upward flow of blood to the heart. Thedeep veins 75 comprise one way valves that prevent the blood from flowing backward. Thedeep veins 75 lie deep within the muscle and carry most of the blood out of theleg 74 and to the heart for oxygenation. Muscles surrounding thedeep veins 75, including the quadriceps, thigh muscles, gastrocnemius, soleus, abductors, peroneus muscles, plantaris muscles and popliteud muscles, compress the one way valves to help force the blood in an upward direction toward the heart. Thedeep veins 75 carry approximately ninety percent of the blood from thelegs 74 to the heart. Variousdeep veins 75 in theleg 74 include, but are not limited to the common iliac, the femoral, the popliteal 71 and thetibial veins 72. - The deep veins generally follow the course of the associated arteries. The
tibial veins 72, also known as the peroneal veins, are located in the calf. The anteriortibial veins 72 pass between the tibia and the fibula along theleg 74. The anteriortibial veins 72 receive blood from the knee joint, muscles of the thigh, and upper calf and the join the posteriortibial vein 72 and thepopliteal vein 71. Thepopliteal vein 71 is formed by the junction of the anterior and posteriortibial veins 72 and ascends to the femoral vein. Thepopliteal vein 71 usually has four valves to assist with the transportation of blood. - The
superficial veins 76 of theleg 74 play a minor role in carrying the blood to the heart. While thesuperficial veins 76 comprise one way valves that are similar to those in thedeep veins 75, the one way valves in thesuperficial veins 76 are not surrounded by muscle. Thesuperficial veins 76 lie above the muscles of theleg 74. Because the one way valves in thesuperficial veins 76 are not surrounded by muscle, the flow of blood upward in thesuperficial veins 76 is much slower when compared to the blood flow in thedeep veins 75. A majority of the blood that flows up thesuperficial veins 76 is diverted into thedeep veins 75 through the short veins 77. Valves in the short veins 77 of theleg 74 allow the blood to flow from thesuperficial veins 76 to thedeep veins 75, but not vice versa. Varioussuperficial veins 76 in theleg 74 include, but are not limited to, the great saphenous and the lesser saphenous veins. - As discussed above, the
deep veins 75, thesuperficial veins 76 and the short veins 77 all have valves that allow blood to flow in one direction only, and prevent the blood from flowing back towards the capillaries and collecting or puddling in the lower leg. Disruption, inversion or damage to the valves can cause the blood to flow down the veins in the wrong direction and puddle in the lower leg. This disruption or damage to the valves causes the veins to enlarge (varicose veins) or cause pain, leg swelling, hypergigmentation and skin ulcers in the part of theleg 74 around the ankle. - The valves in the veins are filamentous and composed of two leaflets that allow blood to flow in only one direction to prevent the blood from falling back into the leg after the leg muscles have helped to propel the blood toward the heart. The
ultrasonic probe 15 of the present invention is atraumatic and does not damage, disrupt or invert the valves. The small diameter of theultrasonic probe 15 allows theultrasonic probe 15 to be transited through an opening in the valve without damaging the valve. The small diameter of theultrasonic probe 15 allows theultrasonic probe 15 to minimize contact with the valves as theultrasonic probe 15 is fed through thedeep vein 75 and valves. The combination of the flexibility of theultrasonic probe 15 and thesmooth probe tip 9 allows theultrasonic probe 15 to be moved through the valve without perforating the membrane comprising the valve while maintaining the integrity of the valve. The flexibility of theultrasonic probe 15 allows theultrasonic probe 15 to be deflected, flexed and bent through thedeep vein 75 and the valves. Thesmooth probe tip 9 also prevents damage, disruption or inversion of the valves upon retraction of theultrasonic probe 15 from thedeep vein 75. - FIG. 5 shows a
thrombus 80 in thedeep vein 75 of theleg 74. The presence of thethrombus 80, or blood clot, in thedeep veins 75 of the leg presents a major risk to a patient. Since the blood from the deep veins travels to the heart and ultimately to the lungs, thethrombus 80 or at least a portion of thethrombus 80 in thedeep veins 75 of theleg 74 can pass through the heart and obstruct the flow of blood to one or more arteries in the lungs, a condition known as pulmonary embolism. The degree of severity of the pulmonary embolism depends on the size of thethrombus 80 and the number of thrombi. Asmall thrombus 80 can block a small artery in the lungs, causing a small piece of lung tissue to die, a condition known as pulmonary infarction. Alarger thrombus 80 presents a life threatening condition since thelarger thrombus 80 can obstruct all or at least a majority of the blood travelling from the right side of the heart to the lungs, thereby causing a quick death. Therefore, removal of thethrombus 80 to treat deep vein thrombosis is critical to the well being of the patient. - FIG. 6 shows the
ultrasonic probe 15 inserted in thedeep vein 75 of theleg 74 being moved toward thethrombus 80. Theultrasonic probe 15 has a stiffness that gives the ultrasonic probe 15 a flexibility allowing theultrasonic probe 15 to be deflected, flexed and bent through the tortuous paths of the vasculature, including thedeep vein 75. Theultrasonic probe 15 can be bent, flexed and deflected to reach thethrombus 80 in thedeep veins 75 of theleg 74 that would otherwise be difficult to reach. - FIG. 7 shows an enlarged view of a portion of the longitudinal axis of the
ultrasonic probe 15 in communication with thethrombus 80 in thedeep vein 75 of theleg 74. With theultrasonic probe 15 in communication with thethrombus 80, theultrasonic energy source 99 is activated to provide a low power electric signal of between about 2 watts to about 6 watts to the transducer that is located within thehandle 88. The transducer converts electrical energy provided by theultrasonic energy source 99 to mechanical energy. The operating frequency of the ultrasonicmedical device 11 is set by the transducer and theultrasonic energy source 99 finds the resonant frequency of the transducer through a Phase Lock Loop. By an appropriately oriented and driven cylindrical array of piezoelectric crystals of the transducer, the horn creates a longitudinal wave along at least a portion of the longitudinal axis of theultrasonic probe 15. The longitudinal wave is converted to a transverse wave along at least a portion of the longitudinal axis of theultrasonic probe 15 through a nonlinear dynamic buckling of theultrasonic probe 15. - As the transverse wave is transmitted along the longitudinal axis of the
ultrasonic probe 15, a transverse ultrasonic vibration is created along the longitudinal axis of theultrasonic probe 15. Theultrasonic probe 15 is vibrated in a transverse mode of vibration. The transverse mode of vibration of theultrasonic probe 15 differs from an axial (or longitudinal) mode of vibration disclosed in the prior art. The transverse ultrasonic vibrations along the longitudinal axis of theultrasonic probe 15 create a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of theultrasonic probe 15. - FIG. 8 shows the
ultrasonic probe 15 of the present invention having a plurality oftransverse nodes 40 and a plurality oftransverse anti-nodes 42 along a portion of the longitudinal axis of theultrasonic probe 15 and in communication with thethrombus 80. Thetransverse nodes 40 are areas of minimum energy and minimum vibration. Thetransverse anti-nodes 42, or areas of maximum energy and maximum vibration, also occur at repeating intervals along the portion of the longitudinal axis of theultrasonic probe 15. The number oftransverse nodes 40 andtransverse anti-nodes 42, and the spacing of thetransverse nodes 40 andtransverse anti-nodes 42 of theultrasonic probe 15 depend on the frequency of energy produced by theultrasonic energy source 99. The separation of thetransverse nodes 40 andtransverse anti-nodes 42 is a function of the frequency, and can be affected by tuning theultrasonic probe 15. In a properly tunedultrasonic probe 15, thetransverse anti-nodes 42 will be found at a position exactly one half of the distance between thetransverse nodes 40 located adjacent to each side of thetransverse anti-nodes 42. - The transverse wave is transmitted along the longitudinal axis of the
ultrasonic probe 15 and the interaction of the surface of theultrasonic probe 15 with the medium surrounding theultrasonic probe 15 creates an acoustic wave in the surrounding medium. As the transverse wave is transmitted along the longitudinal axis of theultrasonic probe 15, theultrasonic probe 15 vibrates transversely. The transverse motion of theultrasonic probe 15 produces cavitation in the medium surrounding theultrasonic probe 15 to ablate thethrombus 80. Cavitation is a process in which small voids are formed in a surrounding medium through the rapid motion of theultrasonic probe 15 and the voids are subsequently forced to compress. The compression of the voids creates a wave of acoustic energy which acts to dissolve the matrix binding thethrombus 80, while having no damaging effects on healthy tissue. Action of theultrasonic probe 15 results in fibrinolysis and surface erosion of thethrombus 80. - The
thrombus 80 in thedeep vein 75 is resolved into a particulate having a size on the order of red blood cells (approximately 5 microns in diameter). The size of the particulate is such that the particulate is easily discharged from the body through conventional methods or simply dissolves into the blood stream. A conventional method of discharging the particulate from the body includes transferring the particulate through the blood stream to the kidney where the particulate is excreted as bodily waste. By resolving thethrombus 80 in thedeep vein 75 to a particulate, the particulate will travel with the blood to the heart and ultimately to the arteries of the lungs without any risk of obstructing the arteries and causing a pulmonary embolism or a pulmonary infarction. - The transverse ultrasonic vibration of the
ultrasonic probe 15 results in a portion of the longitudinal axis of theultrasonic probe 15 vibrated in a direction not parallel to the longitudinal axis of theultrasonic probe 15. The transverse vibration results in movement of the longitudinal axis of theultrasonic probe 15 in a direction approximately perpendicular to the longitudinal axis of theultrasonic probe 15. Transversely vibrating ultrasonic probes for biological material ablation are described in the Assignee's U.S. Pat. No. 6,551,337; U.S. Pat. No. 6,652,547; and U.S. Pat. No. 6,660,013 and Assignee's co-pending patent application U.S. Ser. No. 09/917,471, which further describe the design parameters for such an ultrasonic probe and its use in ultrasonic devices for ablation, and the entirety of these patents and patent applications are hereby incorporated herein by reference. - As a consequence of the transverse ultrasonic vibration of the
ultrasonic probe 15, the thrombus destroying effects of the ultrasonicmedical device 11 are not limited to those regions of theultrasonic probe 15 that may come into contact with thethrombus 80. Rather, as a section of the longitudinal axis of theultrasonic probe 15 is positioned in proximity to thethrombus 80, thethrombus 80 is removed in all areas adjacent to the plurality of energetictransverse nodes 40 andtransverse anti-nodes 42 that are produced along the portion of the length of the longitudinal axis of theultrasonic probe 15, typically in a region having a radius of up to about 6 mm around theultrasonic probe 15. - A novel feature of the present invention is the ability to utilize
ultrasonic probes 15 of extremely small diameter compared to prior art probes, without loss of efficiency, because the thrombus fragmentation process is not dependent on the area of theprobe tip 9. Highly flexibleultrasonic probes 15 can therefore be designed to mimic device shapes that enable facile insertion into thrombus areas or extremely narrow interstices that contain thethrombus 80. Another advantage provided by the present invention is the ability to rapidly move thethrombus 80 from large areas within cylindrical or tubular surfaces. - The number of
transverse nodes 40 andtransverse anti-nodes 42 occurring along the longitudinal axis of theultrasonic probe 15 is modulated by changing the frequency of energy supplied by theultrasonic energy source 99. The exact frequency, however, is not critical and theultrasonic energy source 99 run at, for example, about 20 kHz is sufficient to create an effective number of thrombus destroyingtransverse anti-nodes 42 along the longitudinal axis of theultrasonic probe 15. The low frequency requirement of the present invention is a further advantage in that the low frequency requirement leads to less damage to healthy tissue. Those skilled in the art understand it is possible to adjust the dimensions of theultrasonic probe 15, including diameter, length and distance to theultrasonic energy source 99, in order to affect the number and spacing of thetransverse nodes 40 andtransverse anti-nodes 42 along a portion of the longitudinal axis of theultrasonic probe 15. - The present invention allows the use of ultrasonic energy to be applied to the
thrombus 80 selectively, because theultrasonic probe 15 conducts energy across a frequency range from about 10 kHz through about 100 kHz. The amount of ultrasonic energy to be applied to a particular treatment site is a function of the amplitude and frequency of vibration of theultrasonic probe 15. In general, the amplitude or throw rate of the energy is in the range of about 25 microns to about 250 microns, and the frequency in the range of about 10 kHz to about 100 kHz. In a preferred embodiment of the present invention, the frequency of ultrasonic energy is from about 20 kHz to about 35 kHz. - The present invention also provides a method of preventing deep vein thrombosis. A medical professional gains access to the
deep vein 75 in theleg 74 through an insertion point in thedeep vein 75. A device including, but not limited to, a vascular introducer can be used to create an insertion point in thedeep vein 75 to gain access to thedeep vein 75. A vascular introducer for use with an ultrasonic probe is described in Assignee's co-pending patent application U.S. Ser. No. 10/080,787, and the entirety of this application is hereby incorporated herein by reference. - After gaining access to the
deep vein 75 in theleg 74, theultrasonic probe 15 is moved through the insertion point of thedeep vein 75, navigated through thedeep vein 75 and placed adjacent to thethrombus 80. In a preferred embodiment of the present invention, theultrasonic probe 15 is inserted in thedeep vein 75 below thethrombus 80 and navigated upward with the flow of blood in thedeep vein 75 toward thethrombus 80. Less force is required in moving theultrasonic probe 15 with the flow of blood because there is less friction and viscous drag. In an alternative embodiment of the present invention, theultrasonic probe 15 is inserted in the deep vein above thethrombus 80 and navigated downward against the flow of blood in thedeep vein 75 toward thethrombus 80. While a greater force is required to navigate theultrasonic probe 15 against the flow of blood, the strength of theultrasonic probe 15 permits movement against the flow of blood. Whether theultrasonic probe 15 enters above or below thethrombus 80 is often dictated by anatomical considerations of the patient. - The
ultrasonic probe 15 is placed in communication with thethrombus 80 by sweeping, twisting or rotating theultrasonic probe 15 along thethrombus 80. Those skilled in the art will recognize the ultrasonic probe can be placed in communication with the thrombus in many ways known in the art and be within the spirit and scope of the present invention. - The
ultrasonic probe 15 is placed in communication with thethrombus 80 and theultrasonic energy source 99 engaged to theultrasonic probe 15 is activated to generate a transverse ultrasonic vibration along at least a portion of the longitudinal axis of theultrasonic probe 15. The ultrasonic probe may then be swept, twisted or rotated along thethrombus 80. The transverse ultrasonic vibration creates a plurality of transverse nodes and a plurality of transverse anti-nodes along a portion of the longitudinal axis of theultrasonic probe 15, causing a thrombus destroying effect along the portion of the length of the longitudinal axis of theultrasonic probe 15. - The present invention also is a method of ablating the
thrombus 80 in thedeep vein 75 of the body. Access to thedeep vein 75 in theleg 74 is gained by creating an insertion point in thedeep vein 75 using a device such as a vascular introducer. Theultrasonic probe 15 having theproximal end 31, thedistal end 24 terminating in theprobe tip 9 and a longitudinal axis between the proximal end and thedistal end 24 is inserted through the insertion point of thedeep vein 75 and moved through thedeep vein 75 and placed in communication with thethrombus 80. A stiffness of theultrasonic probe 15 of the ultrasonicmedical device 11 gives the ultrasonic probe 15 a flexibility allowing theultrasonic probe 15 to be deflected, flexed and bent through the tortuous paths of the vasculature, including thedeep vein 75. Theultrasonic energy source 99 engaged to theultrasonic probe 15 is activated to produce an electric signal to drive the transducer of the ultrasonicmedical device 11 to produce a transverse vibration of theultrasonic probe 15. The transverse ultrasonic vibration of theultrasonic probe 15 produces cavitation in a medium surrounding a portion of the length of the longitudinal axis of theultrasonic probe 15 to ablate thethrombus 80. - A method of resolving deep vein thrombosis comprising providing an ultrasonic
medical device 11 comprising anultrasonic probe 15 having aproximal end 31, adistal end 24 and a longitudinal axis therebetween; navigating theultrasonic probe 15 proximal to athrombus 80; placing theultrasonic probe 15 in communication with thethrombus 80; activating anultrasonic energy source 99 engaged to theultrasonic probe 15 to generate a transverse ultrasonic vibration along at least a portion of the longitudinal axis of theultrasonic probe 15, wherein the transverse vibration creates a plurality oftransverse nodes 40 and a plurality oftransverse anti-nodes 42 along a portion of the longitudinal axis of theultrasonic probe 15. - A method of ablating a
thrombus 80 in adeep vein 75 of a body comprising providing an ultrasonicmedical device 11 comprising anultrasonic probe 15 having aproximal end 31, adistal end 24 terminating in aprobe tip 9, and a longitudinal axis between theproximal end 31 and thedistal end 24; inserting theultrasonic probe 15 in an insertion point of thedeep vein 75; moving theultrasonic probe 15 to place theultrasonic probe 15 in communication with thethrombus 80; activating anultrasonic energy source 99 engaged to theultrasonic probe 15 to produce an electric signal that drives a transducer of the ultrasonicmedical device 11 to produce a transverse ultrasonic vibration of theultrasonic probe 15, wherein the transverse ultrasonic vibration produces cavitation in a medium surrounding theultrasonic probe 15 to ablate thethrombus 80. - In an alternative embodiment of the present invention, the
ultrasonic probe 15 is vibrated in a torsional mode. In the torsional mode of vibration, a portion of the longitudinal axis of theultrasonic probe 15 comprises a radially asymmetric cross section and the length of theultrasonic probe 15 is chosen to be resonant in the torsional mode. In the torsional mode of vibration, a transducer transmits ultrasonic energy received from theultrasonic energy source 99 to theultrasonic probe 15, causing theultrasonic probe 15 to vibrate torsionally. Theultrasonic energy source 99 produces the electrical energy that is used to produce a torsional vibration along the longitudinal axis of theultrasonic probe 15. The torsional vibration is a torsional oscillation whereby equally spaced points along the longitudinal axis of theultrasonic probe 15 including theprobe tip 9 vibrate back and forth in a short arc about the longitudinal axis of theultrasonic probe 15. A section proximal to each of a plurality of torsional nodes and a section distal to each of the plurality of torsional nodes are vibrated out of phase, with the proximal section vibrated in a clockwise direction and the distal section vibrated in a counterclockwise direction, or vice versa. The torsional vibration results in an ultrasonic energy transfer to the biological material with minimal loss of ultrasonic energy that could limit the effectiveness of the ultrasonicmedical device 11. The torsional vibration produces a rotation and a counterrotation along the longitudinal axis of theultrasonic probe 15 that creates the plurality of torsional nodes and a plurality of torsional anti-nodes along a portion of the longitudinal axis of theultrasonic probe 15 resulting in cavitation along the portion of the longitudinal axis of theultrasonic probe 15 comprising the radially asymmetric cross section in a medium surrounding theultrasonic probe 15 that ablates the biological material. An apparatus and method for an ultrasonic medical device operating in a torsional mode is described in Assignee's co-pending patent application U.S. Ser. No. 00/000,000 (Attorney Docket No. 20563/2422), filed Feb. 9, 2004, and the entirety of this application is hereby incorporated herein by reference. - In another embodiment of the present invention, the
ultrasonic probe 15 is vibrated in a torsional mode and a transverse mode. A transducer transmits ultrasonic energy from theultrasonic energy source 99 to theultrasonic probe 15, creating a torsional vibration of theultrasonic probe 15. The torsional vibration induces a transverse vibration along an active area of theultrasonic probe 15, creating a plurality of nodes and a plurality of anti-nodes along the active area that result in cavitation in a medium surrounding theultrasonic probe 15. The active area of theultrasonic probe 15 undergoes both the torsional vibration and the transverse vibration. - Depending upon physical properties (i.e., length, diameter, etc.) and material properties (i.e., yield strength, modulus, etc.) of the
ultrasonic probe 15, the transverse vibration is excited by the torsional vibration. Coupling of the torsional mode of vibration and the transverse mode of vibration is possible because of common shear components for the elastic forces. The transverse vibration is induced when the frequency of the transducer is close to a transverse resonant frequency of theultrasonic probe 15. The combination of the torsional mode of vibration and the transverse mode of vibration is possible because for each torsional mode of vibration, there are many close transverse modes of vibration. By applying tension on theultrasonic probe 15, for example by bending theultrasonic probe 15, the transverse vibration is tuned into coincidence with the torsional vibration. The bending causes a shift in frequency due to changes in tension. In the torsional mode of vibration and the transverse mode of vibration, the active area of theultrasonic probe 15 is vibrated in a direction not parallel to the longitudinal axis of theultrasonic probe 15 while equally spaced points along the longitudinal axis of theultrasonic probe 15 in a proximal section vibrate back and forth in a short arc about the longitudinal axis of theultrasonic probe 15. An apparatus and method for an ultrasonic medical device operating in a transverse mode and a torsional mode is described in Assignee's co-pending patent application U.S. Ser. No. 00/000,000 (Attorney Docket No. 20563/2432), filed Feb. 9, 2004, and the entirety of this application is hereby incorporated herein by reference. - While the above discussion and figures focus on the venous removal of the
thrombus 80, the present invention can also be used for the arterial removal of thethrombus 80. Theultrasonic probe 15 of the present invention can not only be used in the deep veins of the leg for venous removal ofthrombus 80, but theultrasonic probe 15 can also be adapted for use in the arteries of the leg for arterial removal ofthrombus 80. - The present invention provides and apparatus and a method for an ultrasonic medical device to treat deep vein thrombosis. An ultrasonic probe is used to ablate a thrombus in a deep vein of the leg, preventing the thrombus, or a portion of the thrombus, from being carried with the blood to the heart and obstructing the flow of blood to one or more arteries in the lungs. The present invention provides an ultrasonic medical device to treat deep vein thrombosis that is simple, user-friendly, time efficient, reliable and cost effective.
- All patents, patent applications, and published references cited herein are hereby incorporated herein by reference in their entirety. While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.
Claims (31)
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US10/779,250 US20040162571A1 (en) | 1999-10-05 | 2004-02-13 | Apparatus and method for an ultrasonic medical device to treat deep vein thrombosis |
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US10/779,250 US20040162571A1 (en) | 1999-10-05 | 2004-02-13 | Apparatus and method for an ultrasonic medical device to treat deep vein thrombosis |
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Also Published As
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US20040097996A1 (en) | 2004-05-20 |
WO2005037086A3 (en) | 2005-08-11 |
WO2005034793A2 (en) | 2005-04-21 |
US8790359B2 (en) | 2014-07-29 |
US20140324066A1 (en) | 2014-10-30 |
WO2005037086A2 (en) | 2005-04-28 |
US20170231649A1 (en) | 2017-08-17 |
WO2005034793A3 (en) | 2005-08-11 |
US20070225619A1 (en) | 2007-09-27 |
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