US20050125073A1 - Implant device for cartilage regeneration in load bearing articulation regions - Google Patents

Implant device for cartilage regeneration in load bearing articulation regions Download PDF

Info

Publication number
US20050125073A1
US20050125073A1 US10/730,423 US73042303A US2005125073A1 US 20050125073 A1 US20050125073 A1 US 20050125073A1 US 73042303 A US73042303 A US 73042303A US 2005125073 A1 US2005125073 A1 US 2005125073A1
Authority
US
United States
Prior art keywords
plate
implant
implant device
load transfer
platform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
US10/730,423
Other versions
US7666230B2 (en
Inventor
Janine Orban
Herbert Schwartz
Nathaniel Grobe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Products Inc
Original Assignee
DePuy Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DePuy Products Inc filed Critical DePuy Products Inc
Priority to US10/730,423 priority Critical patent/US7666230B2/en
Assigned to DEPUY PRODUCTS, INC. reassignment DEPUY PRODUCTS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ORBAN, JANINE M., GROBE, NATHANIEL W., SCHWARTZ, HERBERT E.
Priority to EP04257488A priority patent/EP1541095A3/en
Priority to AU2004235623A priority patent/AU2004235623A1/en
Priority to JP2004354481A priority patent/JP2005169117A/en
Publication of US20050125073A1 publication Critical patent/US20050125073A1/en
Application granted granted Critical
Publication of US7666230B2 publication Critical patent/US7666230B2/en
Expired - Fee Related legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30721Accessories
    • A61F2/30749Fixation appliances for connecting prostheses to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30062(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/3011Cross-sections or two-dimensional shapes
    • A61F2002/30112Rounded shapes, e.g. with rounded corners
    • A61F2002/30113Rounded shapes, e.g. with rounded corners circular
    • A61F2002/30116Rounded shapes, e.g. with rounded corners circular partial circles, i.e. circular segments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/3011Cross-sections or two-dimensional shapes
    • A61F2002/30138Convex polygonal shapes
    • A61F2002/30153Convex polygonal shapes rectangular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/3011Cross-sections or two-dimensional shapes
    • A61F2002/30138Convex polygonal shapes
    • A61F2002/30156Convex polygonal shapes triangular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/3011Cross-sections or two-dimensional shapes
    • A61F2002/30138Convex polygonal shapes
    • A61F2002/30158Convex polygonal shapes trapezoidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30224Three-dimensional shapes cylindrical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30224Three-dimensional shapes cylindrical
    • A61F2002/30225Flat cylinders, i.e. discs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30224Three-dimensional shapes cylindrical
    • A61F2002/30225Flat cylinders, i.e. discs
    • A61F2002/30227Flat cylinders, i.e. discs arched, domed or vaulted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30224Three-dimensional shapes cylindrical
    • A61F2002/30233Stepped cylinders, i.e. having discrete diameter changes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30224Three-dimensional shapes cylindrical
    • A61F2002/30235Three-dimensional shapes cylindrical tubular, e.g. sleeves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30261Three-dimensional shapes parallelepipedal
    • A61F2002/30265Flat parallelepipeds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/3028Three-dimensional shapes polyhedral different from parallelepipedal and pyramidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30327The prosthesis having different structural features at different locations within the same prosthesis differing in diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30331Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
    • A61F2002/30332Conically- or frustoconically-shaped protrusion and recess
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30383Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by laterally inserting a protrusion, e.g. a rib into a complementarily-shaped groove
    • A61F2002/30403Longitudinally-oriented cooperating ribs and grooves on mating lateral surfaces of a mainly longitudinal connection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30428Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by inserting a protrusion into a slot
    • A61F2002/30429Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by inserting a protrusion into a slot made by inserting a hook into a cooperating slot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30476Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism
    • A61F2002/305Snap connection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30599Special structural features of bone or joint prostheses not otherwise provided for stackable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30604Special structural features of bone or joint prostheses not otherwise provided for modular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30721Accessories
    • A61F2/30749Fixation appliances for connecting prostheses to the body
    • A61F2002/30751Fixation appliances for connecting prostheses to the body for attaching cartilage scaffolds to underlying bone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • A61F2002/30766Scaffolds for cartilage ingrowth and regeneration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772Apertures or holes, e.g. of circular cross section
    • A61F2002/30784Plurality of holes
    • A61F2002/30785Plurality of holes parallel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30878Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30878Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30884Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30878Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30891Plurality of protrusions
    • A61F2002/30896Plurality of protrusions perpendicular with respect to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0033Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0006Rounded shapes, e.g. with rounded corners circular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017Angular shapes
    • A61F2230/0019Angular shapes rectangular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017Angular shapes
    • A61F2230/0023Angular shapes triangular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017Angular shapes
    • A61F2230/0026Angular shapes trapezoidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0069Three-dimensional shapes cylindrical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0082Three-dimensional shapes parallelepipedal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/006Additional features; Implant or prostheses properties not otherwise provided for modular
    • A61F2250/0063Nested prosthetic parts

Definitions

  • the present invention relates to regeneration of cartilaginous tissue in load bearing regions and/or the tendency toward the resorption of subchondral bone and, more particularly, to an implant device for reducing the resorption of subchondral bone and thereby enhancing the regeneration of cartilaginous tissue in load bearing regions.
  • osteochondral defect model is ideal for the generation of cartilage neotissue because access to the traumatized bone bed allows for recruitment of precursor cells, thereby enhancing the intrinsic wound healing response.
  • osteochondral defects in the non-load-bearing areas heal spontaneously, albeit with fibrous tissue.
  • the load-bearing region is known to not heal spontaneously, and is characteristically accompanied by resorption of osseous walls and the formation of cavitary lesions.
  • mosaicplasty utilizes cartilaginous plugs, but due to the need to harvest tissue from other sites, this technique is sometimes viewed as being suboptimal. Therefore, research has focused on the use of implant devices.
  • implant devices In published U.S. patent application 2001/0039455A1, prosthetic bio-compatible polyurethane plugs that mimic the materials properties of the adjacent bone or cartilage tissue layer are described. These implants are intended to fill a cartilaginous defect with a non-resorbable cartilage-like material. However, application of load to subchondral bone is not described.
  • U.S. Pat. No. 6,511,511 describes a fiber-reinforced, porous, biodegradable implant in which the fibers act like struts to provide strength and stiffness to the scaffold and provide support for physiological loads.
  • One particular embodiment is for osteochondral defects. Loading, however, is discussed only with respect to the device resisting high compressive stresses in the defect region thereby protecting the implant during tissue regeneration.
  • U.S. published U.S. patent application 2002/0119177 describes a method for reinforcing the mechanical and handling properties of a resorbable foam matrix using a mesh-like fabric. The primary purpose of the reinforcing mesh is to maintain the integrity of the foam component for surgical handling.
  • an implantable device that can induce compression, tension, shear and other biomechanical forces to cells in order to induce cell proliferation and thus wound healing.
  • the device is essentially a bioreactor that exerts micromechanical stimulation to cells through materials properties or application of external forces. This is taught, however, with respect to the regeneration of cartilage and not with respect to the healing of the subchondral bone as in the present invention.
  • the present invention is an implant device for applying a load to osteochondral defects.
  • the present invention provides cartilage regeneration of osteochondral defects in load bearing regions.
  • the implant may be fashioned as one integral device or may be fashioned as two or more portions that are attached to one another.
  • the implant includes an upper platform structure and a lower platform structure with a load transfer structure situated there between.
  • a fixation structure may be included that aids in anchoring the implant to the defect area.
  • the implant is comprised of a resorbable polymeric material or materials such as polyesters (polylactide, polyglycolide, polycaprolactone, polydioxanone, or combination thereof), co-polymers of resorbable polymers, or blends thereof.
  • an implant device for an osteochondral defect includes a first plate made of a resorbable biocompatible material, a second plate made of the resorbable biocompatible material, and a load transfer structure made of the resorbable biocompatible material and situated between the first plate and the second plate.
  • an implant device for an osteochondral defect in another form, there is provided an implant device for an osteochondral defect.
  • the implant device includes an upper plate made of a resorbable biocompatible polymer, a lower plate made of the resorbable biocompatible polymer and having a plurality of exposure bores, and a load transfer structure situated between the upper plate and the lower plate.
  • an implant for load bearing bone articulation surfaces includes an upper plate made of a bio-resorbable polymer and having an upper center bore, a lower plate made of the bio-resorbable polymer and having a lower center bore surrounded by a plurality of exposure bores, and a plurality of load transfer supports situated between a lower surface of the upper plate and an upper surface of the lower plate, the load transfer supports surrounding the upper and lower center bores.
  • FIG. 1 is a diagrammatic view showing a tibial platform, representing an exemplary bone platform, being below the condyles of the femur; representing exemplary condyles; may also want to show patella.
  • FIG. 2 is a block diagram illustrating an exemplary general form of a load bearing cartilage regeneration device in accordance with the principles of the subject invention
  • FIG. 3 is an enlarged perspective view of an exemplary embodiment of a load bearing cartilage regeneration device in accordance with the principles of the subject invention
  • FIG. 4 is a side view of the load bearing cartilage regeneration device of FIG. 3 ;
  • FIG. 5 is a sectional view of the load bearing cartilage regeneration device of FIG. 4 taken along line 5 - 5 thereof, particularly showing the lower platform thereof;
  • FIG. 6 is a sectional view of the load bearing cartilage regeneration device of FIG. 4 taken along line 6 - 6 thereof, particularly showing the upper platform thereof; including the load transferring structure.
  • FIG. 7 is an enlarged perspective view of another exemplary embodiment of a load bearing cartilage regeneration device in accordance with the principles of the subject invention.
  • FIG. 8 is a side view of the load bearing cartilage regeneration device of FIG. 7 ;
  • FIG. 9 is a sectional view of the load bearing cartilage regeneration device of FIG. 8 taken along line 9 - 9 thereof, particularly showing the lower platform thereof; including the load transferring structure.
  • FIG. 10 is a side view of another exemplary embodiment of a load bearing cartilage regeneration device in accordance with the principles of the subject invention.
  • FIG. 11 is a sectional view of the load bearing cartilage regeneration device of FIG. 10 taken along line 11 - 11 thereof, particularly showing the lower platform thereof; including the load transferring structure.
  • FIG. 12 is an enlarged bottom perspective view of an alternative upper platform utilizable with the various exemplary embodiments.
  • FIG. 13 is a side view of the upper platform of FIG. 12 ;
  • FIG. 14 is an enlarged top perspective view of an alternative embodiment of a platform having integral load transfer structures for a two-piece load bearing cartilage regeneration device, the load transfer structures designed to engage mating structures on a mating platform of the two-piece load bearing cartilage regeneration device such as that depicted in FIG. 16 ;
  • FIG. 15 is a top view of the platform of FIG. 14 ;
  • FIG. 16 is an enlarged top perspective view of an exemplary mating platform for the platform structure of FIG. 14 ;
  • FIG. 17 is a side view of the exemplary mating platform of FIG. 16 ;
  • FIG. 18 is a sectional view of the exemplary mating platform of FIG. 17 taken along line 18 - 18 thereof;
  • FIG. 19 is a top plan view of the exemplary mating platform of FIG. 16 ;
  • FIG. 20 is a sectional view of the exemplary mating platform of FIG. 19 taken along line 20 - 20 thereof;
  • FIG. 21 is an enlarged top perspective view of another exemplary mating platform for the platform structure of FIG. 14 ;
  • FIG. 22 is a top plan view of the exemplary mating platform of FIG. 21 ;
  • FIG. 23 is a side view of the exemplary mating platform of FIG. 21 ;
  • FIG. 24 is a sectional view of the exemplary mating platform of FIG. 23 taken along line 24 - 24 thereof;
  • FIG. 25 is an enlarged top perspective view of another alternative embodiment of a platform having integral load transfer structures for a two-piece load bearing cartilage regeneration device, the load transfer structures designed to engage mating structures on a mating platform of the two-piece load bearing cartilage regeneration device;
  • FIG. 26 is an enlarged top perspective view of yet another alternative embodiment of a platform having integral load transfer structures for a two-piece load bearing cartilage regeneration device, the load transfer structures designed to engage mating structures on a mating platform of the two-piece load bearing cartilage regeneration device;
  • FIG. 28 is a side view of the exemplary mating platform of FIG. 27 ;
  • FIG. 29 is a sectional view of the exemplary mating platform of FIG. 28 taken along line 29 - 29 thereof;
  • FIG. 30 is a top plan view of the exemplary mating platform of FIG. 27 ;
  • FIG. 31 is a sectional view of the exemplary mating platform of FIG. 30 taken along line 31 - 31 thereof;
  • FIG. 32 is an enlarged side sectional view of a bone and cartilage platform depicting an exemplary load bearing cartilage regeneration device in accordance with the principles of the present invention implanted therein.
  • FIG. 1 there is depicted a bone platform generally designated 40 being situated below condyles 42 .
  • the bone platform 40 of FIG. 1 is depicted as a tibial platform 40 of a tibia 41 while the condyles 42 are of a femur/knee. It should be appreciated that the tibial platform 40 and condyles 42 are representative of any similar bone platform.
  • the tibial platform 40 supports a meniscus 44 that is over subchondral bone 45 .
  • the tibial platform 40 is assumed to have an osteochondral defect.
  • the subject invention provides an implantable device for the osteochondral defect.
  • the condyles 42 typically exert a load represented by arrows L onto the tibial platform 40 .
  • the condyles 42 of the femur 43 exert physiological loading on the tibial platform 40 during normal joint use.
  • the implant is actually intended for a medial femoral condylar (MFC) defect, and our initial data is in the MFC.
  • MFC medial femoral condylar
  • FIG. 2 there is depicted a block diagram of a load bearing subchondral bone resorption reduction and/or cartilage regeneration implant device generally designated 50 (and, hereinafter, “load bearing implant device”, “implant” or the like) in accordance with the principles of the subject invention.
  • the load bearing implant device 50 is representative of a general structure of the various embodiments of the present load bearing implant device shown and/or described herein.
  • the load bearing implant device 50 includes a first or upper platform, plate or the like 52 and a second or lower platform, plate or the like 54 . It should be appreciated that the designations “first”, “second”, “upper” and “lower” are arbitrary.
  • a load transfer structure 56 is interposed between the upper and lower platforms 52 , 54 .
  • the load transfer structure 56 may take various forms but supports and transfers loading (e.g. physiological loading) exerted on the upper platform 52 to the lower platform 54 .
  • the lower platform 54 transfers the loading exerted thereon by the load transfer structure 56 to the substance of the area in which it is implanted (e.g. subchondral bone).
  • the load bearing implant device 50 is also shown with a fixation device 58 .
  • the fixation device 58 is depicted in dashed lines to indicate the optional nature thereof. Thus, the fixation device 58 is not a necessary portion of the implant 50 . It is preferable, however, that the implant has some sort of fixation device.
  • the fixation device 58 extends generally axially from the lower platform 54 and is utilized to aid in mounting the load bearing implant device 50 into the bone platform.
  • the fixation device 58 may take various forms which are suitable for mounting the implant into bone (e.g., tibia 41 or condyle 43 ).
  • the upper and lower platforms 52 , 54 are axially spaced from one another by the load transfer structure 56 .
  • An area 60 between the upper platform 52 and the lower platform 54 may be utilized to retain a scaffold, matrix or the like of a resorbable material that supports cartilage regeneration (e.g. a bio or artificial material).
  • the area 60 may be termed a scaffold or matrix retention area.
  • the load bearing implant device 50 is designed such that the scaffold or matrix may be inserted before or after the device 50 has been implanted into the bone platform. Whether or not the scaffold or matrix is inserted before or after implantation may depend on the particular form of the load bearing implant device 50 . Particularly, a one-piece implant design may have the scaffold before implantation thereof, while a two-piece implant may receive the scaffold after implantation thereof.
  • the load bearing implant device 50 is comprised of a bio-resorbable (resorbable) material.
  • the resorbable material is preferably a poly(ester)s such as poly(lactide), poly(glycolide), poly(caprolactone), poly(dioxanone) or any combination, co-polymer or blend thereof. Other types of resorbable material(s) may also be used.
  • the lower platform 54 is preferably, but not necessarily, rigid yet porous. Such porosity may be effected by a porous material or the incorporation of bores, holes, pores or the like. As such the lower platform 54 allows the body access to biologic elements (bone and marrow) from the subchondral bone of the bone platform when the implant device 50 is implanted.
  • the upper plate 52 is preferably likewise rigid, but may or may not be porous.
  • the load transfer structure 56 may be rigidly attached to both the upper plate 52 and the bottom plate 54 such that the load bearing implant device 50 is generally of a unitary or single piece structure. Particularly, the load transfer structure 56 adjoins the lower surface 53 of the upper plate 52 and the upper surface 55 of the lower plate 54 .
  • the load transfer structure 56 may be rigidly attached to the upper plate 52 and include a mechanism, structure or configuration that attaches or connects to the lower plate 54 via a mating mechanism, structure or configuration.
  • the attributes of the general load bearing implant device 50 as described above is applicable to the various particular embodiments of the load bearing implant device described hereinafter. Therefore, unless noted otherwise, the load bearing implant devices described hereinbelow, have and/or exhibit the same attributes as those described for the implant device 50 .
  • FIGS. 3-6 there is depicted an exemplary embodiment of a load bearing implant generally designated 62 in accordance with the present principles. Initially, it should be appreciated that the load bearing implant 62 is shown inverted 180° with respect to the load bearing implant device 50 of FIG. 3 . This is for ease of depicting the optional fixation device portion 70 thereof.
  • the load bearing implant device 62 includes a first plate, platform or the like 64 having a plurality of exposure pores, holes, bores or the like 65 .
  • the plurality of exposure holes 65 (here six of which are shown) are arranged in an annular manner about the plate 64 .
  • the number and/or arrangement of the exposure holes 65 is generally arbitrary, but may be arranged to control the exposure of the defect area and scaffold to the normal joint environment. The greater the hole area (hole size and hole number), the greater the exposure.
  • the plate 64 also includes a center hole or bore 76 that aids in insertion of the device 62 into the bone platform. 76 is the load-transferring mechanism, which in this case is a ring-shaped structure.
  • the load bearing implant device 62 also includes a second plate, platform or the like 66 having a plurality of exposure pores, holes, bores or the like 67 .
  • the plurality of exposure holes 67 (here six of which are shown) are arranged in an annular manner about the plate 66 .
  • the number and/or arrangement of the holes 67 is generally arbitrary, but may be arranged to control the exposure of the defect area and scaffold to the normal joint environment. The greater the hole area (hole size and hole number), the greater the exposure.
  • the plate 66 also includes a center hole or bore 75 that aids in insertion of the device 62 into the bone platform.
  • the center hole 75 is intended to be just another bore.
  • the fixation device 70 comprises a tubular body 71 that axially projects from the second plate 66 .
  • the tubular body 71 has an axial bore 72 that is aligned coaxially with the center holes 75 and 77 of plates 66 and 64 respectively.
  • a plurality of fins (anchors) 73 radially project from the tubular body 71 .
  • the fins 73 are fashioned as triangles.
  • the fins may be embodied as ribs, barbs or the like and aid in the retention of the tubular body 71 in a bore in a defect area in the bone platform (see FIG. 32 and accompanying description).
  • the fixation device 70 may takes other forms.
  • the load bearing implant device 62 of FIGS. 3-6 includes a load transfer structure 68 .
  • the load transfer structure 68 is embodied as a plurality (e.g. four as shown) of arc shaped or arcuate walls, portions, sections or the like 76 .
  • the arcuate walls 76 are situated about the center holes 75 and 77 of the plates 66 and 64 .
  • the load transfer structure 68 is rigidly attached to both the first and second plates 64 and 66 to comprise a one-piece load bearing implant device.
  • the load bearing implant device 62 also defines a cartilage scaffold/matrix retention area 74 between the platforms 64 and 66 .
  • the retention area 74 receives and retains a cartilage scaffold/matrix such as is known in the art.
  • the load bearing implant device 80 is preferably made of the same material(s) as previously discussed.
  • the load bearing implant device 80 has an upper or first plate or platform 82 and a lower or second plate or platform 84 .
  • the upper plate 82 includes a plurality of bores or holes 83 for defect area exposure in like manner to the load bearing implant device 62 .
  • the plurality of exposure bores 83 are arcuately spaced about a center bore 86 .
  • the lower plate includes a plurality of bores or holes 85 for defect area exposure in like manner as the upper plate 82 .
  • the plurality of bores 85 are arcuately spaced about the center bore 87 .
  • the number, size and/or arrangement of the bores 83 and 85 of the respective plates 82 and 84 may be modified as appropriate.
  • the load bearing implant device 80 also defines a cartilage scaffold/matrix retention area 90 between the platforms 82 and 84 .
  • the retention area 90 receives and retains the cartilage scaffold/matrix.
  • the load bearing implant device 80 of FIGS. 7-9 also includes a load transfer structure 88 .
  • the load transfer structure 88 is embodied as a plurality (e.g. six as shown) of columns, cylinders or the like 92 .
  • the columns walls 92 are situated about the center holes 86 and 87 of the plates 82 and 84 .
  • the load transfer structure 88 is rigidly attached to both the first and second plates 82 and 84 to comprise a one-piece load bearing implant device. Placement of the load transfer columns 92 may vary as appropriate.
  • the load bearing implant device 80 is preferably made of the same material(s) as previously discussed.
  • the load bearing implant device 96 includes an upper plate 98 and a lower plate 100 .
  • the upper plate 98 may or may not have exposure holes.
  • the lower plate 100 includes a plurality of exposure bores 101 that are arcuately arranged in the plate about a center bore 108 .
  • the number, size and/or arrangement of the bores 101 of the plate 100 may be modified as appropriate.
  • the load bearing implant device 96 also defines a cartilage scaffold/matrix retention area 104 between the platforms 98 and 100 .
  • the retention area 104 receives and retains the cartilage scaffold/matrix.
  • the load bearing implant device 80 of FIGS. 10 and 11 includes a load transfer structure 102 .
  • the load transfer structure 102 is embodied as a plurality (e.g. three as shown) of rectangular walls, blocks or the like 106 .
  • the rectangular walls 92 extend radially from the center hole 108 of the plate 100 .
  • the load transfer structure 102 is rigidly attached to both the first and second plates 98 and 100 to comprise a one-piece or unitary load bearing implant device.
  • the upper plate 110 is preferably, but not necessarily, made of a polymeric material such as that described above.
  • the upper plate 110 may be used in any of the implant embodiments shown herein. Particularly, the upper plate 110 may be used in place of the upper plate of any of the load bearing implant devices shown and/or described herein, or may be attached to the upper plate of any of the load bearing implant devices shown and/or described herein.
  • the plate 110 is defined by a body 112 having a domed portion 114 surrounded by a rim 118 .
  • the dome portion 114 defines a convex articulating surface 115 and thus a concave underside surface 117 .
  • the configuration of the modified top 110 provides a condylar-shaped articulating surface.
  • the plate 110 does not include exposure holes. In lieu of such exposure holes, the plate 110 may be porous or solid.
  • one form of the present load bearing implant device is a two-piece design rather than a single piece design. It should be appreciated, however, that the load bearing implant device may be fashioned from more than two pieces if appropriate.
  • an alternative embodiment of an upper platform structure is shown, generally designated 120 , for a two-piece load bearing implant device.
  • the upper platform structure 120 is again preferably made of a polymeric material as described above.
  • the upper platform structure 120 includes a plate 122 having a plurality of exposure holes or bores 124 arcuately arranged about a center bore 123 .
  • a load transfer structure 125 is integral with the plate 122 (i.e. a unitary structure).
  • the load transfer structure 125 consists of a plurality (e.g., three as depicted) of rectangular blocks or walls 126 each having a mating structure 128 .
  • the load transfer structure 125 may consist of columns, rings, wedges or the like.
  • the rectangular blocks extend radially outward from the center hole 123 toward the periphery of the plate 122 .
  • Each mating or attachment structure 128 includes first and second prongs 130 and 131 . Each prong extends axially upward then radially outward to define a hook shape. The hook shape provides mating of the prongs with a configured lower plate as shown in FIGS. 16-20 .
  • FIGS. 16-20 there is depicted an exemplary lower platform structure generally designated 132 that may be used with the upper plate structure 120 of FIGS. 14-15 .
  • the upper and lower platform structures 120 and 132 provide a two-piece snap or press fit implant design.
  • the lower plate structure 132 is defined by a platform or plate 134 having a plurality of exposure bores 136 .
  • the plurality of exposure bores 136 are arcuately provided about a center bore 137 . Again, the size, number and/or arrangement of the exposure bores 136 are appropriate for the degree of exposure desired.
  • the plate 134 further defines a rim 141 having a tapered, beveled, or radiused edge 138 .
  • Extending radially outwardly from the center bore 137 is a plurality of rectangular bores 139 each of which has a ledge, shelf, protrusion, tab or the like 140 that extends therein as part of a connection, attachment or mating structure.
  • Each bore and ledge combination is configured to receive a prong 130 / 131 of each load transfer structure 126 . This provides a snap or press fit attachment or connection of the upper platform structure 120 with the lower platform structure 132 .
  • the upper platform structure 120 is shown with two prongs 130 / 131 on each load transfer structure 126 , while the receiving bores 139 of the lower plate structure 132 shows only one snap receiving structure 140 for clarity. In order to actually receive the upper platform structure onto the lower platform structure, there would either be only one prong on the load transfer structure of the upper platform structure, or there would be two receiving structures in the receiving bore.
  • the two-piece structure of the load bearing implant device defined by the upper platform structure 120 and the lower platform structure 132 allows for easier manufacture of the implant device. Moreover, once the lower platform structure 132 is implanted into the patient, the resorbable cartilage scaffold/matrix is situated thereon. The upper platform structure 120 is then situated onto the lower platform structure 120 . This gives the user the ability to select the type of resorbable scaffold/matrix material to be used with the load bearing implant device.
  • FIGS. 21-24 there is depicted an alternative embodiment of a lower platform structure, generally designated 150 , that may be used with the upper platform structure of FIGS. 14-15 .
  • the lower platform structure 150 provides a twist and lock configuration for receiving, attaching and retaining an upper platform structure.
  • the lower platform structure 150 is preferably made of a resorbable polymeric material such as that described above.
  • the lower platform structure 150 is preferably a unitary piece.
  • the lower platform structure 150 is defined by a disk-shaped body, plate or the like 152 defining a first surface 153 and an opposite second surface 155 .
  • the plate 152 further defines an annular rim or periphery 157 having an annular taper, bevel or angled portion 158 transitioning between the rim 157 and the angled portion 158 .
  • the plate 152 includes a plurality of exposure bores or holes 154 that are arranged about a center bore or hole 156 . As with previous plates, the size, number and arrangement of the exposure holes 154 and/or the center hole 156 , as well as whether to incorporate exposure holes or not, are subject to discretion depending on exposure factors. Additionally, the plate 152 has a plurality (e.g. three as shown) of configured bores 160 arranged about the center hole 156 and adjacent the exposure holes 154 . Each configured bore 160 is adapted to receive and retain a mating structure (e.g., mating structure 128 of FIG. 14 ) of the load transfer structure (e.g., load transfer structure 125 of FIG. 14 ) of the upper platform (e.g., upper platform structure 120 of FIG. 14 ).
  • a mating structure e.g., mating structure 128 of FIG. 14
  • the load transfer structure e.g., load transfer structure 125 of FIG. 14
  • the upper platform e.g., upper platform structure 120
  • Each configured bore 160 has a projection, ledge, shelf or the like 162 projecting into the interior of the bore.
  • the ledge 162 defines a retention mechanism for a prong of the upper platform structure.
  • Each prong would require a separate ledge.
  • each configured bore 160 would require two ledge structures.
  • FIG. 25 there is depicted another exemplary embodiment of an upper platform structure generally designated 170 .
  • the upper platform structure 170 provides another example of one portion of a two-piece load bearing implant structure.
  • the upper platform structure 170 provides a structure that is retained onto a lower plate (see, e.g., plate 210 of FIGS. 27-31 ) in a press or snap fit manner.
  • the upper platform structure 170 is made of a polymeric material such as that described above and includes a plate 172 and a plurality of load transfer structures 176 that each axially extend from an upper surface 175 of the plate 172 .
  • the plate 172 also includes a center bore 174 .
  • Each load transfer structure 176 is fashioned as a wedge having a mating structure 178 thereon.
  • Each mating structure 178 is configured to be press fit received into a complementary lower platform structure or plate.
  • each mating structure 178 is here embodied as a truncated cone (cone section) 180 having two, diametrically opposed flanges 181 . While only two flanges 181 are shown, the cone section 180 may support more or less flanges 181 as deemed appropriate.
  • the upper platform structure 190 provides another example of one portion of a two-piece load bearing implant structure. Particularly, the upper platform structure 190 provides a structure that is retained onto a lower plate (see, e.g., plate 210 of FIGS. 27-31 ) in a press or snap fit manner.
  • the upper platform structure 190 is made of a polymeric material such as that described above and includes a plate 192 having a plurality of exposure bores 194 arranged about a center hole 196 .
  • the plate 192 supports a plurality of load transfer structures 198 that each axially extend from an upper surface 195 of the plate 192 .
  • Each load transfer structure 198 is configured as a column, tube or the like having a first conical section or annular taper 200 and a second conical section, cone or tapered head 202 .
  • the cone 202 defines a skirt 203 that provides a manner of preventing the pulling out or reversal of the load transfer structure 198 when inserted into the corresponding lower platform structure. Cone 202 is intended to provide a mechanism for fixation into the subchondral bone.
  • the lower platform structure 210 is defined by a body 212 in the shape of a plate, platform or the like that is fashioned from a suitable resorbable polymeric material such as that described above.
  • the plate 212 defines an annular rim or periphery 218 between a first surface 213 and a second surface 215 . Additionally, the plate 212 has an annular taper, bevel or angled surface 219 providing a transition between the rim 219 and the second surface 215 .
  • the plate 212 further includes a plurality of exposure holes 216 that are arranged about a center bore 214 .
  • the size, number and/or arrangement of the exposure bores 216 are modifiable as necessary.
  • Situated between each exposure bore 216 is a receiving, reception or mating bore 220 for a plurality of receiving bores 220 .
  • each receiving bore 220 is conical in shape and includes notches 221 .
  • the notches 221 allow for the reception of the flanges 181 of the load transfer structures 180 of the upper platform structure 170 of FIG. 25 , and the reception of the skirt 203 of the upper platform structure 190 of FIG. 26 .
  • FIG. 32 there is depicted an exemplary illustration depicting a load bearing implant device 240 fashioned in accordance with the principles of the subject invention implanted into a defect area 230 of a bone platform 228 .
  • a bore 236 has been formed in the subchondral bone 232 below the defect area in order to accommodate the fixation device 248 of the load bearing implant device 240 .
  • the first or lower plate 244 of the load bearing implant device 240 is situated proximate and/or adjacent the subchondral bone 232 where the cartilage 234 meets the subchondral bone 232 .
  • the second or upper plate 242 of the load bearing implant device 240 is situated at the surface of the cartilage 234 .
  • a scaffold or matrix 252 is situated in between the two plates 242 , 244 within the scaffold/matrix reception area of the load bearing implant device.
  • load or pressure exerted onto the load bearing implant device structure (e.g., upper plate) at the articulating surface transfers the physiologic load to the load transfer structure.
  • the load transfer structure then transfers the load to the device structure (e.g., lower plate) adjacent the defect area of the subchondral bone.
  • This exerted pressure on the subchondral bone reduces the resorption of subchondral bone and/or the stimulation of subchondral bone synthesis.
  • the load bearing implant device itself is resorbable, being preferably made of a resorbable polymeric material or materials.
  • the subject invention also aids in the regeneration of cartilage tissue in load bearing regions with the ability to receive and retain a resorbable, cartilage regeneration scaffold or matrix (mesh, foam or the like).

Abstract

An implant device for cartilage regeneration in loading-bearing regions uses the osteochondral defect model. The implant is formed of resorbable polymeric materials. The implant is designed such that load is transmitted from the articulating surface of the bone platform through the implant to the entire area of subchondral bone of the bone platform. Application of load in this manner results in reduced subchondral bone resorption, leading to joint stabilization and maintenance of normal joint biomechanics. The implant allows for the incorporation therein of a resorbable scaffold or matrix material. The present implant solves the current inability to regenerate cartilage in load-bearing articulating surfaces using engineered scaffold devices.

Description

    FIELD OF THE INVENTION
  • The present invention relates to regeneration of cartilaginous tissue in load bearing regions and/or the tendency toward the resorption of subchondral bone and, more particularly, to an implant device for reducing the resorption of subchondral bone and thereby enhancing the regeneration of cartilaginous tissue in load bearing regions.
  • BACKGROUND OF THE INVENTION
  • Current techniques for repair and/or regeneration of articular lesions (autogenous chondrocyte transplantation and mosaicplasty) are generally considered to be unsatisfactory due to the fact that they require the harvesting of healthy tissue. As such, research has focused on the development of engineered devices that have the ability to stimulate conduction of hyaline-like tissue into the treated regions without using autogenous tissue sources. Such devices would be considered optimized scaffolds.
  • In vivo studies of articular cartilage regeneration typically utilize one of two animal models: the osteochondral defect and the full-thickness chondral defect. The osteochondral defect model is ideal for the generation of cartilage neotissue because access to the traumatized bone bed allows for recruitment of precursor cells, thereby enhancing the intrinsic wound healing response. In fact, osteochondral defects in the non-load-bearing areas heal spontaneously, albeit with fibrous tissue. The load-bearing region, however, is known to not heal spontaneously, and is characteristically accompanied by resorption of osseous walls and the formation of cavitary lesions.
  • In cases where load-bearing surfaces have been investigated with good outcomes, care has been taken not to compromise the subchondral plate (e.g. full-thickness chondral defect model). However, because the chondral defect model does not generate a hematopoietic wound healing response, spontaneous regeneration does not occur and thus cellular therapies are usually used in such circumstances. One notable exception is mosaicplasty. Mosaicplasty in femoral condyle (osteochondral) defects has been shown to maintain subchondral bone structure, further indicating that application of physiologic force plays a role in maintaining subchondral bone integrity.
  • Particularly, mosaicplasty utilizes cartilaginous plugs, but due to the need to harvest tissue from other sites, this technique is sometimes viewed as being suboptimal. Therefore, research has focused on the use of implant devices. In published U.S. patent application 2001/0039455A1, prosthetic bio-compatible polyurethane plugs that mimic the materials properties of the adjacent bone or cartilage tissue layer are described. These implants are intended to fill a cartilaginous defect with a non-resorbable cartilage-like material. However, application of load to subchondral bone is not described.
  • The use of load during cartilage regeneration has been described in several publications. In U.S. Pat. No. 6,530,956 a resorbable cage-like scaffold is described that consists of high porosity material seeded with transplanted chondrocytes. Loading is discussed with respect to the cage-like scaffold for withstanding and resisting compressive forces so that cell growing compartments of the cage-like scaffold are protected during tissue regeneration.
  • U.S. Pat. No. 6,511,511 describes a fiber-reinforced, porous, biodegradable implant in which the fibers act like struts to provide strength and stiffness to the scaffold and provide support for physiological loads. One particular embodiment is for osteochondral defects. Loading, however, is discussed only with respect to the device resisting high compressive stresses in the defect region thereby protecting the implant during tissue regeneration. In a similar manner, U.S. published U.S. patent application 2002/0119177 describes a method for reinforcing the mechanical and handling properties of a resorbable foam matrix using a mesh-like fabric. The primary purpose of the reinforcing mesh is to maintain the integrity of the foam component for surgical handling.
  • In published U.S. patent application 2003/0108587, an implantable device is described that can induce compression, tension, shear and other biomechanical forces to cells in order to induce cell proliferation and thus wound healing. The device is essentially a bioreactor that exerts micromechanical stimulation to cells through materials properties or application of external forces. This is taught, however, with respect to the regeneration of cartilage and not with respect to the healing of the subchondral bone as in the present invention.
  • Thus the need exists for a device for regeneration of articular cartilage that simultaneously applies load to subchondral bone.
  • It is thus an object of the present invention to provide an implant for cartilage regeneration in load-bearing regions.
  • It is thus another object of the present invention to provide an implant that applies a load from an articulating surface of a bone platform to an area of subchondral bone.
  • It is yet another object of the present invention to provide a load bearing implant for that reduces subchondral bone resorption.
  • SUMMARY OF THE INVENTION
  • In one form, the present invention is an implant device for applying a load to osteochondral defects. In another form, the present invention provides cartilage regeneration of osteochondral defects in load bearing regions. The implant may be fashioned as one integral device or may be fashioned as two or more portions that are attached to one another.
  • The implant includes an upper platform structure and a lower platform structure with a load transfer structure situated there between. A fixation structure may be included that aids in anchoring the implant to the defect area. The implant is comprised of a resorbable polymeric material or materials such as polyesters (polylactide, polyglycolide, polycaprolactone, polydioxanone, or combination thereof), co-polymers of resorbable polymers, or blends thereof.
  • The lower platform structure is preferably rigid (and alternatively the upper platform structure as well) and may be porous, or include pores or holes that allow for access to biologic elements (e.g. blood and bone marrow) from the subchondral bone. The implant also allows the receipt and retention of a resorbable scaffold or matrix material for cartilage regeneration in the defect area.
  • Particularly, in one form there is provided an implant device for an osteochondral defect. The implant device includes a first plate made of a resorbable biocompatible material, a second plate made of the resorbable biocompatible material, and a load transfer structure made of the resorbable biocompatible material and situated between the first plate and the second plate.
  • In another form, there is provided an implant device for an osteochondral defect. The implant device includes an upper plate made of a resorbable biocompatible polymer, a lower plate made of the resorbable biocompatible polymer and having a plurality of exposure bores, and a load transfer structure situated between the upper plate and the lower plate.
  • In yet another form, there is provided an implant for load bearing bone articulation surfaces. The implant includes an upper plate made of a bio-resorbable polymer and having an upper center bore, a lower plate made of the bio-resorbable polymer and having a lower center bore surrounded by a plurality of exposure bores, and a plurality of load transfer supports situated between a lower surface of the upper plate and an upper surface of the lower plate, the load transfer supports surrounding the upper and lower center bores.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a diagrammatic view showing a tibial platform, representing an exemplary bone platform, being below the condyles of the femur; representing exemplary condyles; may also want to show patella.
  • FIG. 2 is a block diagram illustrating an exemplary general form of a load bearing cartilage regeneration device in accordance with the principles of the subject invention;
  • FIG. 3 is an enlarged perspective view of an exemplary embodiment of a load bearing cartilage regeneration device in accordance with the principles of the subject invention;
  • FIG. 4 is a side view of the load bearing cartilage regeneration device of FIG. 3;
  • FIG. 5 is a sectional view of the load bearing cartilage regeneration device of FIG. 4 taken along line 5-5 thereof, particularly showing the lower platform thereof;
  • FIG. 6 is a sectional view of the load bearing cartilage regeneration device of FIG. 4 taken along line 6-6 thereof, particularly showing the upper platform thereof; including the load transferring structure.
  • FIG. 7 is an enlarged perspective view of another exemplary embodiment of a load bearing cartilage regeneration device in accordance with the principles of the subject invention;
  • FIG. 8 is a side view of the load bearing cartilage regeneration device of FIG. 7;
  • FIG. 9 is a sectional view of the load bearing cartilage regeneration device of FIG. 8 taken along line 9-9 thereof, particularly showing the lower platform thereof; including the load transferring structure.
  • FIG. 10 is a side view of another exemplary embodiment of a load bearing cartilage regeneration device in accordance with the principles of the subject invention;
  • FIG. 11 is a sectional view of the load bearing cartilage regeneration device of FIG. 10 taken along line 11-11 thereof, particularly showing the lower platform thereof; including the load transferring structure.
  • FIG. 12 is an enlarged bottom perspective view of an alternative upper platform utilizable with the various exemplary embodiments;
  • FIG. 13 is a side view of the upper platform of FIG. 12;
  • FIG. 14 is an enlarged top perspective view of an alternative embodiment of a platform having integral load transfer structures for a two-piece load bearing cartilage regeneration device, the load transfer structures designed to engage mating structures on a mating platform of the two-piece load bearing cartilage regeneration device such as that depicted in FIG. 16;
  • FIG. 15 is a top view of the platform of FIG. 14;
  • FIG. 16 is an enlarged top perspective view of an exemplary mating platform for the platform structure of FIG. 14;
  • FIG. 17 is a side view of the exemplary mating platform of FIG. 16;
  • FIG. 18 is a sectional view of the exemplary mating platform of FIG. 17 taken along line 18-18 thereof;
  • FIG. 19 is a top plan view of the exemplary mating platform of FIG. 16;
  • FIG. 20 is a sectional view of the exemplary mating platform of FIG. 19 taken along line 20-20 thereof;
  • FIG. 21 is an enlarged top perspective view of another exemplary mating platform for the platform structure of FIG. 14;
  • FIG. 22 is a top plan view of the exemplary mating platform of FIG. 21;
  • FIG. 23 is a side view of the exemplary mating platform of FIG. 21;
  • FIG. 24 is a sectional view of the exemplary mating platform of FIG. 23 taken along line 24-24 thereof;
  • FIG. 25 is an enlarged top perspective view of another alternative embodiment of a platform having integral load transfer structures for a two-piece load bearing cartilage regeneration device, the load transfer structures designed to engage mating structures on a mating platform of the two-piece load bearing cartilage regeneration device;
  • FIG. 26 is an enlarged top perspective view of yet another alternative embodiment of a platform having integral load transfer structures for a two-piece load bearing cartilage regeneration device, the load transfer structures designed to engage mating structures on a mating platform of the two-piece load bearing cartilage regeneration device;
  • FIG. 27 is an enlarged top perspective view of an exemplary mating platform for the platform structures of FIGS. 25 and/or 26;
  • FIG. 28 is a side view of the exemplary mating platform of FIG. 27;
  • FIG. 29 is a sectional view of the exemplary mating platform of FIG. 28 taken along line 29-29 thereof;
  • FIG. 30 is a top plan view of the exemplary mating platform of FIG. 27;
  • FIG. 31 is a sectional view of the exemplary mating platform of FIG. 30 taken along line 31-31 thereof; and
  • FIG. 32 is an enlarged side sectional view of a bone and cartilage platform depicting an exemplary load bearing cartilage regeneration device in accordance with the principles of the present invention implanted therein.
  • DETAILED DESCRIPTION OF THE INVENTION
  • While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and will herein be described in detail. It should be understood, however, that there is no intent to limit the invention to the particular forms disclosed, but on the contrary, the intention is to cover all modifications, equivalents and alternatives falling within the spirit and scope of the invention as defined by the appended claims.
  • Referring now to FIG. 1, there is depicted a bone platform generally designated 40 being situated below condyles 42. The bone platform 40 of FIG. 1 is depicted as a tibial platform 40 of a tibia 41 while the condyles 42 are of a femur/knee. It should be appreciated that the tibial platform 40 and condyles 42 are representative of any similar bone platform. The tibial platform 40 supports a meniscus 44 that is over subchondral bone 45. The tibial platform 40 is assumed to have an osteochondral defect. The subject invention provides an implantable device for the osteochondral defect. The condyles 42 typically exert a load represented by arrows L onto the tibial platform 40. Particularly, the condyles 42 of the femur 43 exert physiological loading on the tibial platform 40 during normal joint use. The implant is actually intended for a medial femoral condylar (MFC) defect, and our initial data is in the MFC. Perhaps we should describe FIG. 1 relating to a MFC defect, and mention the other load-bearing surfaces such as the tibia and patella?
  • Referring now to FIG. 2, there is depicted a block diagram of a load bearing subchondral bone resorption reduction and/or cartilage regeneration implant device generally designated 50 (and, hereinafter, “load bearing implant device”, “implant” or the like) in accordance with the principles of the subject invention. The load bearing implant device 50 is representative of a general structure of the various embodiments of the present load bearing implant device shown and/or described herein.
  • The load bearing implant device 50 includes a first or upper platform, plate or the like 52 and a second or lower platform, plate or the like 54. It should be appreciated that the designations “first”, “second”, “upper” and “lower” are arbitrary. A load transfer structure 56 is interposed between the upper and lower platforms 52, 54. The load transfer structure 56 may take various forms but supports and transfers loading (e.g. physiological loading) exerted on the upper platform 52 to the lower platform 54. The lower platform 54 transfers the loading exerted thereon by the load transfer structure 56 to the substance of the area in which it is implanted (e.g. subchondral bone).
  • The load bearing implant device 50 is also shown with a fixation device 58. The fixation device 58 is depicted in dashed lines to indicate the optional nature thereof. Thus, the fixation device 58 is not a necessary portion of the implant 50. It is preferable, however, that the implant has some sort of fixation device. The fixation device 58 extends generally axially from the lower platform 54 and is utilized to aid in mounting the load bearing implant device 50 into the bone platform. The fixation device 58 may take various forms which are suitable for mounting the implant into bone (e.g., tibia 41 or condyle 43).
  • The upper and lower platforms 52, 54 are axially spaced from one another by the load transfer structure 56. An area 60 between the upper platform 52 and the lower platform 54 may be utilized to retain a scaffold, matrix or the like of a resorbable material that supports cartilage regeneration (e.g. a bio or artificial material). As such, the area 60 may be termed a scaffold or matrix retention area. The load bearing implant device 50 is designed such that the scaffold or matrix may be inserted before or after the device 50 has been implanted into the bone platform. Whether or not the scaffold or matrix is inserted before or after implantation may depend on the particular form of the load bearing implant device 50. Particularly, a one-piece implant design may have the scaffold before implantation thereof, while a two-piece implant may receive the scaffold after implantation thereof.
  • The load bearing implant device 50 is comprised of a bio-resorbable (resorbable) material. The resorbable material is preferably a poly(ester)s such as poly(lactide), poly(glycolide), poly(caprolactone), poly(dioxanone) or any combination, co-polymer or blend thereof. Other types of resorbable material(s) may also be used.
  • The lower platform 54 is preferably, but not necessarily, rigid yet porous. Such porosity may be effected by a porous material or the incorporation of bores, holes, pores or the like. As such the lower platform 54 allows the body access to biologic elements (bone and marrow) from the subchondral bone of the bone platform when the implant device 50 is implanted. The upper plate 52 is preferably likewise rigid, but may or may not be porous.
  • The load transfer structure 56 may be rigidly attached to both the upper plate 52 and the bottom plate 54 such that the load bearing implant device 50 is generally of a unitary or single piece structure. Particularly, the load transfer structure 56 adjoins the lower surface 53 of the upper plate 52 and the upper surface 55 of the lower plate 54. Alternatively, the load transfer structure 56 may be rigidly attached to the upper plate 52 and include a mechanism, structure or configuration that attaches or connects to the lower plate 54 via a mating mechanism, structure or configuration.
  • It should be appreciated that the attributes of the general load bearing implant device 50 as described above is applicable to the various particular embodiments of the load bearing implant device described hereinafter. Therefore, unless noted otherwise, the load bearing implant devices described hereinbelow, have and/or exhibit the same attributes as those described for the implant device 50.
  • Referring now to FIGS. 3-6, there is depicted an exemplary embodiment of a load bearing implant generally designated 62 in accordance with the present principles. Initially, it should be appreciated that the load bearing implant 62 is shown inverted 180° with respect to the load bearing implant device 50 of FIG. 3. This is for ease of depicting the optional fixation device portion 70 thereof.
  • The load bearing implant device 62 includes a first plate, platform or the like 64 having a plurality of exposure pores, holes, bores or the like 65. The plurality of exposure holes 65 (here six of which are shown) are arranged in an annular manner about the plate 64. The number and/or arrangement of the exposure holes 65 is generally arbitrary, but may be arranged to control the exposure of the defect area and scaffold to the normal joint environment. The greater the hole area (hole size and hole number), the greater the exposure. The plate 64 also includes a center hole or bore 76 that aids in insertion of the device 62 into the bone platform. 76 is the load-transferring mechanism, which in this case is a ring-shaped structure.
  • The load bearing implant device 62 also includes a second plate, platform or the like 66 having a plurality of exposure pores, holes, bores or the like 67. Again, the plurality of exposure holes 67 (here six of which are shown) are arranged in an annular manner about the plate 66. The number and/or arrangement of the holes 67 is generally arbitrary, but may be arranged to control the exposure of the defect area and scaffold to the normal joint environment. The greater the hole area (hole size and hole number), the greater the exposure. The plate 66 also includes a center hole or bore 75 that aids in insertion of the device 62 into the bone platform. The center hole 75 is intended to be just another bore.
  • The fixation device 70 comprises a tubular body 71 that axially projects from the second plate 66. The tubular body 71 has an axial bore 72 that is aligned coaxially with the center holes 75 and 77 of plates 66 and 64 respectively. A plurality of fins (anchors) 73 radially project from the tubular body 71. The fins 73 are fashioned as triangles. The fins may be embodied as ribs, barbs or the like and aid in the retention of the tubular body 71 in a bore in a defect area in the bone platform (see FIG. 32 and accompanying description). Of course, the fixation device 70, may takes other forms.
  • The load bearing implant device 62 of FIGS. 3-6 includes a load transfer structure 68. The load transfer structure 68 is embodied as a plurality (e.g. four as shown) of arc shaped or arcuate walls, portions, sections or the like 76. The arcuate walls 76 are situated about the center holes 75 and 77 of the plates 66 and 64. In this embodiment, the load transfer structure 68 is rigidly attached to both the first and second plates 64 and 66 to comprise a one-piece load bearing implant device.
  • The load bearing implant device 62 also defines a cartilage scaffold/matrix retention area 74 between the platforms 64 and 66. The retention area 74 receives and retains a cartilage scaffold/matrix such as is known in the art.
  • Referring now to FIGS. 7-9, there is depicted an alternative embodiment of the present load bearing implant device generally designated 80. The load bearing implant device 80 is preferably made of the same material(s) as previously discussed. The load bearing implant device 80 has an upper or first plate or platform 82 and a lower or second plate or platform 84. The upper plate 82 includes a plurality of bores or holes 83 for defect area exposure in like manner to the load bearing implant device 62. The plurality of exposure bores 83 are arcuately spaced about a center bore 86. The lower plate includes a plurality of bores or holes 85 for defect area exposure in like manner as the upper plate 82. The plurality of bores 85 are arcuately spaced about the center bore 87. The number, size and/or arrangement of the bores 83 and 85 of the respective plates 82 and 84 may be modified as appropriate.
  • The load bearing implant device 80 also defines a cartilage scaffold/matrix retention area 90 between the platforms 82 and 84. The retention area 90 receives and retains the cartilage scaffold/matrix.
  • The load bearing implant device 80 of FIGS. 7-9 also includes a load transfer structure 88. The load transfer structure 88 is embodied as a plurality (e.g. six as shown) of columns, cylinders or the like 92. The columns walls 92 are situated about the center holes 86 and 87 of the plates 82 and 84. In this embodiment, the load transfer structure 88 is rigidly attached to both the first and second plates 82 and 84 to comprise a one-piece load bearing implant device. Placement of the load transfer columns 92 may vary as appropriate.
  • Referring now to FIGS. 10 and 11, another alternative embodiment of a load bearing implant device is shown, generally designated 96. The load bearing implant device 80 is preferably made of the same material(s) as previously discussed. The load bearing implant device 96 includes an upper plate 98 and a lower plate 100. The upper plate 98 may or may not have exposure holes.. The lower plate 100 includes a plurality of exposure bores 101 that are arcuately arranged in the plate about a center bore 108. The number, size and/or arrangement of the bores 101 of the plate 100 may be modified as appropriate.
  • The load bearing implant device 96 also defines a cartilage scaffold/matrix retention area 104 between the platforms 98 and 100. The retention area 104 receives and retains the cartilage scaffold/matrix.
  • The load bearing implant device 80 of FIGS. 10 and 11 includes a load transfer structure 102. The load transfer structure 102 is embodied as a plurality (e.g. three as shown) of rectangular walls, blocks or the like 106. The rectangular walls 92 extend radially from the center hole 108 of the plate 100. In this embodiment, the load transfer structure 102 is rigidly attached to both the first and second plates 98 and 100 to comprise a one-piece or unitary load bearing implant device.
  • Referring now to FIGS. 12 and 13, an alternative embodiment or modification of an upper plate or platform is shown, generally designated 110. The upper plate 110 is preferably, but not necessarily, made of a polymeric material such as that described above. The upper plate 110 may be used in any of the implant embodiments shown herein. Particularly, the upper plate 110 may be used in place of the upper plate of any of the load bearing implant devices shown and/or described herein, or may be attached to the upper plate of any of the load bearing implant devices shown and/or described herein.
  • The plate 110 is defined by a body 112 having a domed portion 114 surrounded by a rim 118. The dome portion 114 defines a convex articulating surface 115 and thus a concave underside surface 117. The configuration of the modified top 110 provides a condylar-shaped articulating surface. Preferably, but not necessarily, the plate 110 does not include exposure holes. In lieu of such exposure holes, the plate 110 may be porous or solid.
  • As indicated above, one form of the present load bearing implant device is a two-piece design rather than a single piece design. It should be appreciated, however, that the load bearing implant device may be fashioned from more than two pieces if appropriate.
  • Referring now to FIGS. 14 and 15, an alternative embodiment of an upper platform structure is shown, generally designated 120, for a two-piece load bearing implant device. The upper platform structure 120 is again preferably made of a polymeric material as described above.
  • The upper platform structure 120 includes a plate 122 having a plurality of exposure holes or bores 124 arcuately arranged about a center bore 123. A load transfer structure 125 is integral with the plate 122 (i.e. a unitary structure). The load transfer structure 125 consists of a plurality (e.g., three as depicted) of rectangular blocks or walls 126 each having a mating structure 128. Of course, the load transfer structure 125 may consist of columns, rings, wedges or the like. The rectangular blocks extend radially outward from the center hole 123 toward the periphery of the plate 122. Each mating or attachment structure 128 includes first and second prongs 130 and 131. Each prong extends axially upward then radially outward to define a hook shape. The hook shape provides mating of the prongs with a configured lower plate as shown in FIGS. 16-20.
  • Referring now to FIGS. 16-20, there is depicted an exemplary lower platform structure generally designated 132 that may be used with the upper plate structure 120 of FIGS. 14-15. The upper and lower platform structures 120 and 132 provide a two-piece snap or press fit implant design. The lower plate structure 132 is defined by a platform or plate 134 having a plurality of exposure bores 136. The plurality of exposure bores 136 are arcuately provided about a center bore 137. Again, the size, number and/or arrangement of the exposure bores 136 are appropriate for the degree of exposure desired.
  • The plate 134 further defines a rim 141 having a tapered, beveled, or radiused edge 138. Extending radially outwardly from the center bore 137 is a plurality of rectangular bores 139 each of which has a ledge, shelf, protrusion, tab or the like 140 that extends therein as part of a connection, attachment or mating structure. Each bore and ledge combination is configured to receive a prong 130/131 of each load transfer structure 126. This provides a snap or press fit attachment or connection of the upper platform structure 120 with the lower platform structure 132.
  • It should be appreciated that the upper platform structure 120 is shown with two prongs 130/131 on each load transfer structure 126, while the receiving bores 139 of the lower plate structure 132 shows only one snap receiving structure 140 for clarity. In order to actually receive the upper platform structure onto the lower platform structure, there would either be only one prong on the load transfer structure of the upper platform structure, or there would be two receiving structures in the receiving bore.
  • The two-piece structure of the load bearing implant device defined by the upper platform structure 120 and the lower platform structure 132 allows for easier manufacture of the implant device. Moreover, once the lower platform structure 132 is implanted into the patient, the resorbable cartilage scaffold/matrix is situated thereon. The upper platform structure 120 is then situated onto the lower platform structure 120. This gives the user the ability to select the type of resorbable scaffold/matrix material to be used with the load bearing implant device.
  • With the two-piece axial snap or press fit design of FIGS. 14-20, almost all of the force that will be exerted onto the implant device will be axial loading. As such, there the upper platform structure 120 will resist separation from the lower platform structure.
  • Referring now to FIGS. 21-24, there is depicted an alternative embodiment of a lower platform structure, generally designated 150, that may be used with the upper platform structure of FIGS. 14-15. The lower platform structure 150 provides a twist and lock configuration for receiving, attaching and retaining an upper platform structure. The lower platform structure 150 is preferably made of a resorbable polymeric material such as that described above. Moreover, the lower platform structure 150 is preferably a unitary piece.
  • The lower platform structure 150 is defined by a disk-shaped body, plate or the like 152 defining a first surface 153 and an opposite second surface 155. The plate 152 further defines an annular rim or periphery 157 having an annular taper, bevel or angled portion 158 transitioning between the rim 157 and the angled portion 158.
  • The plate 152 includes a plurality of exposure bores or holes 154 that are arranged about a center bore or hole 156. As with previous plates, the size, number and arrangement of the exposure holes 154 and/or the center hole 156, as well as whether to incorporate exposure holes or not, are subject to discretion depending on exposure factors. Additionally, the plate 152 has a plurality (e.g. three as shown) of configured bores 160 arranged about the center hole 156 and adjacent the exposure holes 154. Each configured bore 160 is adapted to receive and retain a mating structure (e.g., mating structure 128 of FIG. 14) of the load transfer structure (e.g., load transfer structure 125 of FIG. 14) of the upper platform (e.g., upper platform structure 120 of FIG. 14).
  • Each configured bore 160 has a projection, ledge, shelf or the like 162 projecting into the interior of the bore. The ledge 162 defines a retention mechanism for a prong of the upper platform structure. Each prong would require a separate ledge. Thus, to receive the two-pronged load transfer structure of the upper platform structure of FIGS. 14-15, each configured bore 160 would require two ledge structures. Once a prong is inserted into the configured bore, a twist thereof sets the ledge into under each prong. This motion, twist locks the upper plate platform into the lower plate platform.
  • In FIG. 25, there is depicted another exemplary embodiment of an upper platform structure generally designated 170. The upper platform structure 170 provides another example of one portion of a two-piece load bearing implant structure. Particularly, the upper platform structure 170 provides a structure that is retained onto a lower plate (see, e.g., plate 210 of FIGS. 27-31) in a press or snap fit manner.
  • The upper platform structure 170 is made of a polymeric material such as that described above and includes a plate 172 and a plurality of load transfer structures 176 that each axially extend from an upper surface 175 of the plate 172. The plate 172 also includes a center bore 174.
  • Each load transfer structure 176 is fashioned as a wedge having a mating structure 178 thereon. Each mating structure 178 is configured to be press fit received into a complementary lower platform structure or plate. Particularly, each mating structure 178 is here embodied as a truncated cone (cone section) 180 having two, diametrically opposed flanges 181. While only two flanges 181 are shown, the cone section 180 may support more or less flanges 181 as deemed appropriate.
  • Referring now to FIG. 26, there is shown another exemplary embodiment of an upper platform structure generally designated 190. The upper platform structure 190 provides another example of one portion of a two-piece load bearing implant structure. Particularly, the upper platform structure 190 provides a structure that is retained onto a lower plate (see, e.g., plate 210 of FIGS. 27-31) in a press or snap fit manner.
  • The upper platform structure 190 is made of a polymeric material such as that described above and includes a plate 192 having a plurality of exposure bores 194 arranged about a center hole 196. The plate 192 supports a plurality of load transfer structures 198 that each axially extend from an upper surface 195 of the plate 192. Each load transfer structure 198 is configured as a column, tube or the like having a first conical section or annular taper 200 and a second conical section, cone or tapered head 202. The cone 202 defines a skirt 203 that provides a manner of preventing the pulling out or reversal of the load transfer structure 198 when inserted into the corresponding lower platform structure. Cone 202 is intended to provide a mechanism for fixation into the subchondral bone.
  • Referring now to FIGS. 27-31, there is depicted an exemplary lower platform structure, generally designated 210, that can accommodate either one of the two exemplary upper platform structures 170 of FIG. 25 and 190 of FIG. 26. The lower platform structure 210 is defined by a body 212 in the shape of a plate, platform or the like that is fashioned from a suitable resorbable polymeric material such as that described above. The plate 212 defines an annular rim or periphery 218 between a first surface 213 and a second surface 215. Additionally, the plate 212 has an annular taper, bevel or angled surface 219 providing a transition between the rim 219 and the second surface 215.
  • The plate 212 further includes a plurality of exposure holes 216 that are arranged about a center bore 214. The size, number and/or arrangement of the exposure bores 216 are modifiable as necessary. Situated between each exposure bore 216 is a receiving, reception or mating bore 220 for a plurality of receiving bores 220. As best seen in FIG. 31, each receiving bore 220 is conical in shape and includes notches 221. The notches 221 allow for the reception of the flanges 181 of the load transfer structures 180 of the upper platform structure 170 of FIG. 25, and the reception of the skirt 203 of the upper platform structure 190 of FIG. 26.
  • Referring lastly to FIG. 32, there is depicted an exemplary illustration depicting a load bearing implant device 240 fashioned in accordance with the principles of the subject invention implanted into a defect area 230 of a bone platform 228. A bore 236 has been formed in the subchondral bone 232 below the defect area in order to accommodate the fixation device 248 of the load bearing implant device 240.
  • The first or lower plate 244 of the load bearing implant device 240 is situated proximate and/or adjacent the subchondral bone 232 where the cartilage 234 meets the subchondral bone 232. The second or upper plate 242 of the load bearing implant device 240 is situated at the surface of the cartilage 234. A scaffold or matrix 252 is situated in between the two plates 242, 244 within the scaffold/matrix reception area of the load bearing implant device.
  • In each embodiment, load or pressure exerted onto the load bearing implant device structure (e.g., upper plate) at the articulating surface transfers the physiologic load to the load transfer structure. The load transfer structure then transfers the load to the device structure (e.g., lower plate) adjacent the defect area of the subchondral bone. This exerted pressure on the subchondral bone reduces the resorption of subchondral bone and/or the stimulation of subchondral bone synthesis. The load bearing implant device itself is resorbable, being preferably made of a resorbable polymeric material or materials. The subject invention also aids in the regeneration of cartilage tissue in load bearing regions with the ability to receive and retain a resorbable, cartilage regeneration scaffold or matrix (mesh, foam or the like).

Claims (25)

1. An implant device for an osteochondral defect comprising:
a first plate made of a resorbable biocompatible material;
a second plate made of said resorbable biocompatible material; and
a load transfer structure made of said resorbable biocompatible material and situated between said first plate and said second plate.
2. The implant device of claim 1, wherein said resorbable biocompatible material is a polymer.
3. The implant device of claim 2, wherein said polymer comprises polyester.
4. The implant device of claim 1, wherein said second plate is porous.
5. The implant device of claim 1, wherein said first plate, said second plate and said load transfer structure comprise a unitary structure.
6. The implant device of claim 1, wherein said load transfer structure is integral with said first plate, and receivable by said second plate.
7. The implant device of claim 1, further comprising a fixation device extending from said second plate.
8. An implant device for an osteochondral defect comprising:
an upper plate made of a resorbable biocompatible polymer;
a lower plate made of the resorbable biocompatible polymer and having a plurality of exposure bores; and
a load transfer structure situated between said upper plate and said lower plate.
9. The implant device of claim 8, further comprising a fixation member axially extending from a bottom surface of said lower plate.
10. The implant device of claim 9, wherein said fixation member comprises a stem having a plurality of radially extending barbs.
11. The implant device of claim 8, wherein said implant device is adapted to receive a resorbable cartilage scaffold between said upper plate and said lower plate.
12. The implant device of claim 8, wherein said polymer comprises polyester.
13. The implant device of claim 8, wherein said upper plate is porous.
14. The implant device of claim 8, wherein said upper plate, said lower plate and said load transfer structure comprise a unitary structure.
15. The implant device of claim 8, wherein said load transfer structure is integral with said upper plate and receivable by said lower plate.
16. The implant device of claim 15, wherein said load transfer structure includes an attachment structure configured to be press fit into receiving bores in said lower plate.
17. The implant device of claim 16, wherein said load transfer structure comprises a plurality of individual supports, and said attachment structure comprises an attachment component associated with each individual support.
18. An implant for load bearing bone articulation surfaces comprising:
an upper plate made of a bio-resorbable polymer and having an upper center bore;
a lower plate made of the bio-resorbable polymer and having a lower center bore surrounded by a plurality of exposure bores; and
a plurality of load transfer supports situated between a lower surface of said upper plate and an upper surface of said lower plate, said load transfer supports surrounding said upper and lower center bores.
19. The implant of claim 18, wherein a scaffold retention area is defined about said load transfer supports.
20. The implant of claim 18, further comprising:
a fixation member axially extending from a lower surface of said lower plate.
21. The implant of claim 20, wherein said fixation member comprises:
a tube having a center bore that is coaxial with said upper and lower center bores; and
a plurality of retention flanges extending radially from an outside surface of said tube.
22. The implant of claim 18, wherein said upper plate, said lower plate and said load transfer structure comprise a unitary structure.
23. The implant of claim 18, wherein said load transfer structure is integral with said upper plate and receivable by said lower plate.
24. The implant of claim 23, wherein said load transfer structure includes an attachment structure configured to be press fit into receiving bores in said lower plate.
25. The implant of claim 24, wherein said load transfer structure comprises a plurality of individual supports, and said attachment structure comprises an attachment component associated with each individual support.
US10/730,423 2003-12-08 2003-12-08 Implant device for cartilage regeneration in load bearing articulation regions Expired - Fee Related US7666230B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/730,423 US7666230B2 (en) 2003-12-08 2003-12-08 Implant device for cartilage regeneration in load bearing articulation regions
EP04257488A EP1541095A3 (en) 2003-12-08 2004-12-02 Implant device for cartilage regeneration in load bearing articulation regions
AU2004235623A AU2004235623A1 (en) 2003-12-08 2004-12-02 Implant device for cartilage regeneration in load bearing articulation regions
JP2004354481A JP2005169117A (en) 2003-12-08 2004-12-07 Transplanting device for cartilage regeneration in articulation region to support load

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/730,423 US7666230B2 (en) 2003-12-08 2003-12-08 Implant device for cartilage regeneration in load bearing articulation regions

Publications (2)

Publication Number Publication Date
US20050125073A1 true US20050125073A1 (en) 2005-06-09
US7666230B2 US7666230B2 (en) 2010-02-23

Family

ID=34523011

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/730,423 Expired - Fee Related US7666230B2 (en) 2003-12-08 2003-12-08 Implant device for cartilage regeneration in load bearing articulation regions

Country Status (4)

Country Link
US (1) US7666230B2 (en)
EP (1) EP1541095A3 (en)
JP (1) JP2005169117A (en)
AU (1) AU2004235623A1 (en)

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070233135A1 (en) * 2006-03-28 2007-10-04 Gil Carlos E Osteochondral repair assembly including retracting spacer, kit and method
US20080206297A1 (en) * 2007-02-28 2008-08-28 Roeder Ryan K Porous composite biomaterials and related methods
DE102007014267A1 (en) * 2007-03-21 2008-10-09 Eska Implants Gmbh & Co.Kg Implant production set for refixing e.g. bone fragments, of patient, has clamping devices with osteoinductive surface for bone integration, and fixing devices provided at bone or implant
US7658751B2 (en) 2006-09-29 2010-02-09 Biomet Sports Medicine, Llc Method for implanting soft tissue
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US7857830B2 (en) 2006-02-03 2010-12-28 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US7905903B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Method for tissue fixation
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7914539B2 (en) 2004-11-09 2011-03-29 Biomet Sports Medicine, Llc Tissue fixation device
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US8034090B2 (en) 2004-11-09 2011-10-11 Biomet Sports Medicine, Llc Tissue fixation device
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8221454B2 (en) 2004-02-20 2012-07-17 Biomet Sports Medicine, Llc Apparatus for performing meniscus repair
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8317825B2 (en) 2004-11-09 2012-11-27 Biomet Sports Medicine, Llc Soft tissue conduit device and method
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8475505B2 (en) 2008-08-13 2013-07-02 Smed-Ta/Td, Llc Orthopaedic screws
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US8840645B2 (en) 2004-11-05 2014-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8936621B2 (en) 2006-02-03 2015-01-20 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9358056B2 (en) 2008-08-13 2016-06-07 Smed-Ta/Td, Llc Orthopaedic implant
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US9561354B2 (en) 2008-08-13 2017-02-07 Smed-Ta/Td, Llc Drug delivery implants
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9801708B2 (en) 2004-11-05 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair
US10039543B2 (en) 2014-08-22 2018-08-07 Biomet Sports Medicine, Llc Non-sliding soft anchor
US10136886B2 (en) 2013-12-20 2018-11-27 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
US10517587B2 (en) 2006-02-03 2019-12-31 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US10912551B2 (en) 2015-03-31 2021-02-09 Biomet Sports Medicine, Llc Suture anchor with soft anchor of electrospun fibers
US11259792B2 (en) 2006-02-03 2022-03-01 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US11259794B2 (en) 2006-09-29 2022-03-01 Biomet Sports Medicine, Llc Method for implanting soft tissue
US11311287B2 (en) 2006-02-03 2022-04-26 Biomet Sports Medicine, Llc Method for tissue fixation
US11666447B1 (en) * 2015-03-05 2023-06-06 Taq Ortho, LLC Bone implant augment and offset device
US11678917B1 (en) * 2015-03-05 2023-06-20 Taq Ortho, LLC Bone insert augment and offset method

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) * 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
AU2005304912A1 (en) 2004-11-04 2006-05-18 Smith & Nephew, Inc. Cycle and load measurement device
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
GB0514358D0 (en) * 2005-07-13 2005-08-17 Smith & Nephew Implants for tissue repair
CN103637840A (en) 2005-08-23 2014-03-19 史密夫和内修有限公司 Telemetric orthopaedic implant
EP1926459B1 (en) 2005-09-19 2015-01-07 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US9849216B2 (en) 2006-03-03 2017-12-26 Smith & Nephew, Inc. Systems and methods for delivering a medicament
US9445720B2 (en) 2007-02-23 2016-09-20 Smith & Nephew, Inc. Processing sensed accelerometer data for determination of bone healing
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008296209B2 (en) 2007-09-06 2014-05-29 Smith & Nephew, Inc. System and method for communicating with a telemetric implant
CA2708147A1 (en) * 2007-12-05 2009-06-18 Musculoskeletal Transplant Foundation Cancellous bone implant for cartilage repair
EP2265220A1 (en) * 2008-03-05 2010-12-29 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8801725B2 (en) * 2008-03-10 2014-08-12 Zimmer Orthobiologics, Inc. Instruments and methods used when repairing a defect on a tissue surface
US20100042218A1 (en) * 2008-08-13 2010-02-18 Nebosky Paul S Orthopaedic implant with porous structural member
EP2364115B1 (en) 2008-10-15 2019-02-20 Smith & Nephew, Inc. Composite internal fixators
JP5536793B2 (en) * 2008-11-20 2014-07-02 カルティヘール(2009)エルティーディー. Solid mold for tissue repair
US20100145451A1 (en) 2008-12-04 2010-06-10 Derek Dee Joint support and subchondral support system
US10610364B2 (en) 2008-12-04 2020-04-07 Subchondral Solutions, Inc. Method for ameliorating joint conditions and diseases and preventing bone hypertrophy
NL2002742C2 (en) * 2009-04-09 2010-10-12 Univ Delft Tech Mechanical device for tissue regeneration.
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9113916B2 (en) 2010-08-31 2015-08-25 Zimmer, Inc. Drill bit for osteochondral drilling with guiding element and uses thereof
ES2402035B1 (en) * 2011-10-10 2014-03-07 Universidad Politécnica De Valencia DEVICE FOR SETTING A MACROPOROUS MATERIAL FOR THE REGENERATION OF ARTICULAR CARTRIDGE
US9398928B2 (en) * 2012-09-28 2016-07-26 DePuy Synthes Products, Inc. Adjustable height arthroplasty plate
US9408699B2 (en) 2013-03-15 2016-08-09 Smed-Ta/Td, Llc Removable augment for medical implant
US9724203B2 (en) 2013-03-15 2017-08-08 Smed-Ta/Td, Llc Porous tissue ingrowth structure
US9681966B2 (en) 2013-03-15 2017-06-20 Smed-Ta/Td, Llc Method of manufacturing a tubular medical implant
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10524774B2 (en) 2015-04-02 2020-01-07 Arthrex, Inc. Method of repairing cartilage defects
US10524775B2 (en) 2015-07-02 2020-01-07 Arthrex, Inc. Methods of repairing cartilage defects
EP3838195A1 (en) 2015-11-25 2021-06-23 Subchondral Solutions, Inc. Methods, systems and devices for repairing anatomical joint conditions
TWI682791B (en) * 2018-11-26 2020-01-21 財團法人金屬工業研究發展中心 Cartilage implant
EP3659554A1 (en) * 2018-11-29 2020-06-03 The Provost, Fellows, Scholars and other Members of Board of Trinity College Dublin An anchoring pin

Citations (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5062850A (en) * 1990-01-16 1991-11-05 University Of Florida Axially-fixed vertebral body prosthesis and method of fixation
US5116374A (en) * 1989-03-02 1992-05-26 Regen Corporation Prosthetic meniscus
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5679723A (en) * 1994-11-30 1997-10-21 Ethicon, Inc. Hard tissue bone cements and substitutes
US5713374A (en) * 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5919234A (en) * 1996-08-19 1999-07-06 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US20010014473A1 (en) * 1996-06-04 2001-08-16 Sulzer Orthopedics Ltd. Method for producing cartilagetissue and implants for repairing encholndral and osteochondral defects as well as arrangement for carrying out the method
US20010016353A1 (en) * 1999-06-14 2001-08-23 Janas Victor F. Relic process for producing resorbable ceramic scaffolds
US20010039455A1 (en) * 2000-03-14 2001-11-08 Timothy Simon Cartilage repair plug
US6371958B1 (en) * 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US20020082694A1 (en) * 1999-02-04 2002-06-27 Mckay William F. Highly-mineralized osteogenic sponge compositions, and uses thereof
US20020090391A1 (en) * 1995-02-22 2002-07-11 Peter Geistlich Resorbable extracellular matrix for reconstruction of cartilage
US20020119177A1 (en) * 2000-12-21 2002-08-29 Bowman Steven M. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US20020120274A1 (en) * 2001-02-26 2002-08-29 Ethicon, Inc. Tissue scaffold anchor for cartilage repair
US6444222B1 (en) * 2001-05-08 2002-09-03 Verigen Transplantation Services International Ag Reinforced matrices
US6451059B1 (en) * 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
US20020139147A1 (en) * 2001-01-30 2002-10-03 Janas Victor F. Glass scaffolds with controlled resorption rates and methods for making same
US20020173855A1 (en) * 2001-02-05 2002-11-21 Mansmann Kevin A. Cartilage repair implant with soft bearing surface and flexible anchoring device
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US20030004578A1 (en) * 2001-06-28 2003-01-02 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US6511511B1 (en) * 1997-05-30 2003-01-28 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US20030033021A1 (en) * 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method
US6530956B1 (en) * 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
US20030083665A1 (en) * 2001-10-01 2003-05-01 Paul Re Apparatus and method for the repair of articular cartilage defects
US20030095994A1 (en) * 2001-11-20 2003-05-22 Peter Geistlich Resorbable extracellular matrix containing collagen I and collagen II for reconstruction of cartilage
US6575986B2 (en) * 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US20030108587A1 (en) * 2001-05-15 2003-06-12 Orgill Dennis P. Methods and apparatus for application of micro-mechanical forces to tissues
US6602294B1 (en) * 1999-11-24 2003-08-05 Transtissue Technologies Gmbh Implantable substrates for the healing and protection of connecting tissue, preferably cartilage

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
DE9413778U1 (en) 1994-08-26 1996-01-04 Schaefer Micomed Gmbh Intervertebral implant
AU2759397A (en) 1996-05-28 1998-01-05 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
EP0989855A4 (en) 1997-05-13 2002-06-12 Osiris Therapeutics Inc Osteoarthritis cartilage regeneration using human mesenchymal stem cells
US6416552B1 (en) 1998-12-30 2002-07-09 Biomet, Inc. Method and apparatus for enabling access to an intramedullary canal of a femur through a femoral knee joint prosthesis
AU770196B2 (en) 1999-02-04 2004-02-12 Warsaw Orthopedic, Inc. Osteogenic paste compositions and uses thereof
DE19906172C1 (en) 1999-02-08 2000-07-13 Ethicon Gmbh Resorbable implant used for inducing tissue formation, especially in bone regeneration, has specific density and porosity properties
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
US6530656B1 (en) * 1999-09-30 2003-03-11 Canon Kabushiki Kaisha Color ink-jet recording ink set, ink-jet recording method, recording unit, ink-cartridge, ink-jet recording apparatus and bleeding reduction method
DE19950406A1 (en) 1999-10-20 2001-05-31 Volkmar Jansson System for covering cartilage defects using cartilage replacement structures
WO2001032072A2 (en) 1999-11-01 2001-05-10 Osteobiologics, Inc. Biodegradable polymer/ceramic implant material with bimodal degradation profile
WO2001078798A1 (en) 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
ITPD20010032A1 (en) 2001-02-09 2002-08-09 Fidia Advanced Biopolymers Srl ENGINEERED GRAFTES FOR THE REPAIR OF OSTEOCONDRAL DEFECTS
WO2002071985A1 (en) 2001-03-14 2002-09-19 Drexel University Polymeric bioresorbable composites containing an amorphous calcium phosphate polymer ceramic for bone repair and replacement
US6989034B2 (en) 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices

Patent Citations (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5624463A (en) * 1987-07-20 1997-04-29 Regen Biologics, Inc. Prosthetic articular cartilage
US5116374A (en) * 1989-03-02 1992-05-26 Regen Corporation Prosthetic meniscus
US5062850A (en) * 1990-01-16 1991-11-05 University Of Florida Axially-fixed vertebral body prosthesis and method of fixation
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5679723A (en) * 1994-11-30 1997-10-21 Ethicon, Inc. Hard tissue bone cements and substitutes
US5747390A (en) * 1994-11-30 1998-05-05 Ethicon, Inc. Hard tissue bone cements and substitutes
US5713374A (en) * 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US20020090391A1 (en) * 1995-02-22 2002-07-11 Peter Geistlich Resorbable extracellular matrix for reconstruction of cartilage
US6387693B2 (en) * 1996-06-04 2002-05-14 Sulzer Orthopedics Ltd. Method for producing cartilage tissue and implants for repairing enchondral and osteochondral defects as well as arrangement for carrying out the method
US20010014473A1 (en) * 1996-06-04 2001-08-16 Sulzer Orthopedics Ltd. Method for producing cartilagetissue and implants for repairing encholndral and osteochondral defects as well as arrangement for carrying out the method
US5919234A (en) * 1996-08-19 1999-07-06 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6511511B1 (en) * 1997-05-30 2003-01-28 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US20030075822A1 (en) * 1997-05-30 2003-04-24 Michael Slivka Fiber-reinforced, porous, biodegradable implant device
US6530956B1 (en) * 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
US20020082694A1 (en) * 1999-02-04 2002-06-27 Mckay William F. Highly-mineralized osteogenic sponge compositions, and uses thereof
US20010016353A1 (en) * 1999-06-14 2001-08-23 Janas Victor F. Relic process for producing resorbable ceramic scaffolds
US6451059B1 (en) * 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
US6602294B1 (en) * 1999-11-24 2003-08-05 Transtissue Technologies Gmbh Implantable substrates for the healing and protection of connecting tissue, preferably cartilage
US6371958B1 (en) * 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US20010039455A1 (en) * 2000-03-14 2001-11-08 Timothy Simon Cartilage repair plug
US20020119177A1 (en) * 2000-12-21 2002-08-29 Bowman Steven M. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US20020139147A1 (en) * 2001-01-30 2002-10-03 Janas Victor F. Glass scaffolds with controlled resorption rates and methods for making same
US20020173855A1 (en) * 2001-02-05 2002-11-21 Mansmann Kevin A. Cartilage repair implant with soft bearing surface and flexible anchoring device
US20020120274A1 (en) * 2001-02-26 2002-08-29 Ethicon, Inc. Tissue scaffold anchor for cartilage repair
US6575986B2 (en) * 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US20030003153A1 (en) * 2001-05-08 2003-01-02 Samuel Asculai Reinforced matrices
US6444222B1 (en) * 2001-05-08 2002-09-03 Verigen Transplantation Services International Ag Reinforced matrices
US20030108587A1 (en) * 2001-05-15 2003-06-12 Orgill Dennis P. Methods and apparatus for application of micro-mechanical forces to tissues
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US20030004578A1 (en) * 2001-06-28 2003-01-02 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US20030033021A1 (en) * 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method
US20030083665A1 (en) * 2001-10-01 2003-05-01 Paul Re Apparatus and method for the repair of articular cartilage defects
US20030095994A1 (en) * 2001-11-20 2003-05-22 Peter Geistlich Resorbable extracellular matrix containing collagen I and collagen II for reconstruction of cartilage

Cited By (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8221454B2 (en) 2004-02-20 2012-07-17 Biomet Sports Medicine, Llc Apparatus for performing meniscus repair
US8551140B2 (en) 2004-11-05 2013-10-08 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US11109857B2 (en) 2004-11-05 2021-09-07 Biomet Sports Medicine, Llc Soft tissue repair device and method
US9801708B2 (en) 2004-11-05 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9572655B2 (en) 2004-11-05 2017-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9504460B2 (en) 2004-11-05 2016-11-29 Biomet Sports Medicine, LLC. Soft tissue repair device and method
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US10265064B2 (en) 2004-11-05 2019-04-23 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8840645B2 (en) 2004-11-05 2014-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7914539B2 (en) 2004-11-09 2011-03-29 Biomet Sports Medicine, Llc Tissue fixation device
US8317825B2 (en) 2004-11-09 2012-11-27 Biomet Sports Medicine, Llc Soft tissue conduit device and method
US8034090B2 (en) 2004-11-09 2011-10-11 Biomet Sports Medicine, Llc Tissue fixation device
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
US10702259B2 (en) 2006-02-03 2020-07-07 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US10973507B2 (en) 2006-02-03 2021-04-13 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US11896210B2 (en) 2006-02-03 2024-02-13 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US11819205B2 (en) 2006-02-03 2023-11-21 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US10154837B2 (en) 2006-02-03 2018-12-18 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8273106B2 (en) 2006-02-03 2012-09-25 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US8292921B2 (en) 2006-02-03 2012-10-23 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7905903B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Method for tissue fixation
US8337525B2 (en) 2006-02-03 2012-12-25 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US11786236B2 (en) 2006-02-03 2023-10-17 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8409253B2 (en) 2006-02-03 2013-04-02 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US11730464B2 (en) 2006-02-03 2023-08-22 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US11723648B2 (en) 2006-02-03 2023-08-15 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US11617572B2 (en) 2006-02-03 2023-04-04 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7857830B2 (en) 2006-02-03 2010-12-28 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US11589859B2 (en) 2006-02-03 2023-02-28 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US11471147B2 (en) 2006-02-03 2022-10-18 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8608777B2 (en) 2006-02-03 2013-12-17 Biomet Sports Medicine Method and apparatus for coupling soft tissue to a bone
US11446019B2 (en) 2006-02-03 2022-09-20 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8632569B2 (en) 2006-02-03 2014-01-21 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US11317907B2 (en) 2006-02-03 2022-05-03 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US11311287B2 (en) 2006-02-03 2022-04-26 Biomet Sports Medicine, Llc Method for tissue fixation
US11284884B2 (en) 2006-02-03 2022-03-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8721684B2 (en) 2006-02-03 2014-05-13 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US11259792B2 (en) 2006-02-03 2022-03-01 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US11116495B2 (en) 2006-02-03 2021-09-14 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US9993241B2 (en) 2006-02-03 2018-06-12 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US11065103B2 (en) 2006-02-03 2021-07-20 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US11039826B2 (en) 2006-02-03 2021-06-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8932331B2 (en) 2006-02-03 2015-01-13 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8936621B2 (en) 2006-02-03 2015-01-20 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US10987099B2 (en) 2006-02-03 2021-04-27 Biomet Sports Medicine, Llc Method for tissue fixation
US9005287B2 (en) 2006-02-03 2015-04-14 Biomet Sports Medicine, Llc Method for bone reattachment
US8771316B2 (en) 2006-02-03 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9173651B2 (en) 2006-02-03 2015-11-03 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US10932770B2 (en) 2006-02-03 2021-03-02 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US10729430B2 (en) 2006-02-03 2020-08-04 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US10729421B2 (en) 2006-02-03 2020-08-04 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US10716557B2 (en) 2006-02-03 2020-07-21 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US9763656B2 (en) 2006-02-03 2017-09-19 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US10695052B2 (en) 2006-02-03 2020-06-30 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10687803B2 (en) 2006-02-03 2020-06-23 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10675073B2 (en) 2006-02-03 2020-06-09 Biomet Sports Medicine, Llc Method and apparatus for sternal closure
US9402621B2 (en) 2006-02-03 2016-08-02 Biomet Sports Medicine, LLC. Method for tissue fixation
US9414833B2 (en) 2006-02-03 2016-08-16 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US10603029B2 (en) 2006-02-03 2020-03-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US10595851B2 (en) 2006-02-03 2020-03-24 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10542967B2 (en) 2006-02-03 2020-01-28 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9468433B2 (en) 2006-02-03 2016-10-18 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US10517587B2 (en) 2006-02-03 2019-12-31 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9492158B2 (en) 2006-02-03 2016-11-15 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9498204B2 (en) 2006-02-03 2016-11-22 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US10441264B2 (en) 2006-02-03 2019-10-15 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US9510819B2 (en) 2006-02-03 2016-12-06 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9510821B2 (en) 2006-02-03 2016-12-06 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US9532777B2 (en) 2006-02-03 2017-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US10398428B2 (en) 2006-02-03 2019-09-03 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US10321906B2 (en) 2006-02-03 2019-06-18 Biomet Sports Medicine, Llc Method for tissue fixation
US9561025B2 (en) 2006-02-03 2017-02-07 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US10004588B2 (en) 2006-02-03 2018-06-26 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US9603591B2 (en) 2006-02-03 2017-03-28 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US10251637B2 (en) 2006-02-03 2019-04-09 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9801620B2 (en) 2006-02-03 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US9622736B2 (en) 2006-02-03 2017-04-18 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9642661B2 (en) 2006-02-03 2017-05-09 Biomet Sports Medicine, Llc Method and Apparatus for Sternal Closure
US10098629B2 (en) 2006-02-03 2018-10-16 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10092288B2 (en) 2006-02-03 2018-10-09 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10022118B2 (en) 2006-02-03 2018-07-17 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US10004489B2 (en) 2006-02-03 2018-06-26 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7572291B2 (en) 2006-03-28 2009-08-11 Warsaw Orthopedic, Inc. Osteochondral repair assembly including retracting spacer, kit and method
US20070233135A1 (en) * 2006-03-28 2007-10-04 Gil Carlos E Osteochondral repair assembly including retracting spacer, kit and method
US8777956B2 (en) 2006-08-16 2014-07-15 Biomet Sports Medicine, Llc Chondral defect repair
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US10695045B2 (en) 2006-09-29 2020-06-30 Biomet Sports Medicine, Llc Method and apparatus for attaching soft tissue to bone
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US8231654B2 (en) 2006-09-29 2012-07-31 Biomet Sports Medicine, Llc Adjustable knotless loops
US9788876B2 (en) 2006-09-29 2017-10-17 Biomet Sports Medicine, Llc Fracture fixation device
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US9724090B2 (en) 2006-09-29 2017-08-08 Biomet Manufacturing, Llc Method and apparatus for attaching soft tissue to bone
US10004493B2 (en) 2006-09-29 2018-06-26 Biomet Sports Medicine, Llc Method for implanting soft tissue
US11672527B2 (en) 2006-09-29 2023-06-13 Biomet Sports Medicine, Llc Method for implanting soft tissue
US10743925B2 (en) 2006-09-29 2020-08-18 Biomet Sports Medicine, Llc Fracture fixation device
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9681940B2 (en) 2006-09-29 2017-06-20 Biomet Sports Medicine, Llc Ligament system for knee joint
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US10835232B2 (en) 2006-09-29 2020-11-17 Biomet Sports Medicine, Llc Fracture fixation device
US11376115B2 (en) 2006-09-29 2022-07-05 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US8672968B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Method for implanting soft tissue
US10610217B2 (en) 2006-09-29 2020-04-07 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9414925B2 (en) 2006-09-29 2016-08-16 Biomet Manufacturing, Llc Method of implanting a knee prosthesis assembly with a ligament link
US11259794B2 (en) 2006-09-29 2022-03-01 Biomet Sports Medicine, Llc Method for implanting soft tissue
US10349931B2 (en) 2006-09-29 2019-07-16 Biomet Sports Medicine, Llc Fracture fixation device
US7658751B2 (en) 2006-09-29 2010-02-09 Biomet Sports Medicine, Llc Method for implanting soft tissue
US9833230B2 (en) 2006-09-29 2017-12-05 Biomet Sports Medicine, Llc Fracture fixation device
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US11096684B2 (en) 2006-09-29 2021-08-24 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9539003B2 (en) 2006-09-29 2017-01-10 Biomet Sports Medicine, LLC. Method and apparatus for forming a self-locking adjustable loop
US10398430B2 (en) 2006-09-29 2019-09-03 Biomet Sports Medicine, Llc Method for implanting soft tissue
US10517714B2 (en) 2006-09-29 2019-12-31 Biomet Sports Medicine, Llc Ligament system for knee joint
US9486211B2 (en) 2006-09-29 2016-11-08 Biomet Sports Medicine, Llc Method for implanting soft tissue
US11612391B2 (en) 2007-01-16 2023-03-28 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
WO2008106625A3 (en) * 2007-02-28 2009-12-30 University Of Notre Dame Du Lac Porous composite biomaterials and related methods
US20080206297A1 (en) * 2007-02-28 2008-08-28 Roeder Ryan K Porous composite biomaterials and related methods
WO2008106625A2 (en) * 2007-02-28 2008-09-04 University Of Notre Dame Du Lac Porous composite biomaterials and related methods
DE102007014267A1 (en) * 2007-03-21 2008-10-09 Eska Implants Gmbh & Co.Kg Implant production set for refixing e.g. bone fragments, of patient, has clamping devices with osteoinductive surface for bone integration, and fixing devices provided at bone or implant
DE102007014267B4 (en) * 2007-03-21 2014-01-02 Jörg Fleischer Set for creating an implant for refixing bone fragments and / or tendon attachments
US11185320B2 (en) 2007-04-10 2021-11-30 Biomet Sports Medicine, Llc Adjustable knotless loops
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US9861351B2 (en) 2007-04-10 2018-01-09 Biomet Sports Medicine, Llc Adjustable knotless loops
US10729423B2 (en) 2007-04-10 2020-08-04 Biomet Sports Medicine, Llc Adjustable knotless loops
US10349993B2 (en) 2008-08-13 2019-07-16 Smed-Ta/Td, Llc Drug delivery implants
US11426291B2 (en) 2008-08-13 2022-08-30 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US8702767B2 (en) 2008-08-13 2014-04-22 Smed-Ta/Td, Llc Orthopaedic Screws
US9358056B2 (en) 2008-08-13 2016-06-07 Smed-Ta/Td, Llc Orthopaedic implant
US8475505B2 (en) 2008-08-13 2013-07-02 Smed-Ta/Td, Llc Orthopaedic screws
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US10357298B2 (en) 2008-08-13 2019-07-23 Smed-Ta/Td, Llc Drug delivery implants
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
US9561354B2 (en) 2008-08-13 2017-02-07 Smed-Ta/Td, Llc Drug delivery implants
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US11534159B2 (en) 2008-08-22 2022-12-27 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8900314B2 (en) 2009-05-28 2014-12-02 Biomet Manufacturing, Llc Method of implanting a prosthetic knee joint assembly
US10149767B2 (en) 2009-05-28 2018-12-11 Biomet Manufacturing, Llc Method of implanting knee prosthesis assembly with ligament link
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US9216078B2 (en) 2011-05-17 2015-12-22 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US9445827B2 (en) 2011-10-25 2016-09-20 Biomet Sports Medicine, Llc Method and apparatus for intraosseous membrane reconstruction
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US10265159B2 (en) 2011-11-03 2019-04-23 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US11241305B2 (en) 2011-11-03 2022-02-08 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US11534157B2 (en) 2011-11-10 2022-12-27 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US10363028B2 (en) 2011-11-10 2019-07-30 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US10368856B2 (en) 2011-11-10 2019-08-06 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9357992B2 (en) 2011-11-10 2016-06-07 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9433407B2 (en) 2012-01-03 2016-09-06 Biomet Manufacturing, Llc Method of implanting a bone fixation assembly
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US10758221B2 (en) 2013-03-14 2020-09-01 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US10806443B2 (en) 2013-12-20 2020-10-20 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
US10136886B2 (en) 2013-12-20 2018-11-27 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
US11648004B2 (en) 2013-12-20 2023-05-16 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US10039543B2 (en) 2014-08-22 2018-08-07 Biomet Sports Medicine, Llc Non-sliding soft anchor
US11219443B2 (en) 2014-08-22 2022-01-11 Biomet Sports Medicine, Llc Non-sliding soft anchor
US10743856B2 (en) 2014-08-22 2020-08-18 Biomet Sports Medicine, Llc Non-sliding soft anchor
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair
US20230210565A1 (en) * 2015-03-05 2023-07-06 Taq Ortho, LLC Bone insert augment and offset method
US11678917B1 (en) * 2015-03-05 2023-06-20 Taq Ortho, LLC Bone insert augment and offset method
US11666447B1 (en) * 2015-03-05 2023-06-06 Taq Ortho, LLC Bone implant augment and offset device
US10912551B2 (en) 2015-03-31 2021-02-09 Biomet Sports Medicine, Llc Suture anchor with soft anchor of electrospun fibers

Also Published As

Publication number Publication date
JP2005169117A (en) 2005-06-30
AU2004235623A1 (en) 2005-06-23
US7666230B2 (en) 2010-02-23
EP1541095A2 (en) 2005-06-15
EP1541095A3 (en) 2006-01-04

Similar Documents

Publication Publication Date Title
US7666230B2 (en) Implant device for cartilage regeneration in load bearing articulation regions
US7066960B1 (en) Intervertebral disk replacement
EP1494625B1 (en) Acetabular constraining components
US6080194A (en) Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
JP4173009B2 (en) Spherical spinal implant
JP4197160B2 (en) Supporting scaffold materials and methods for cartilage repair and regeneration
US20050010304A1 (en) Device and method for reconstruction of osseous skeletal defects
US20140309746A1 (en) Medical implants and methods for delivering biologically active agents
US9445902B2 (en) Platform for soft tissue attachment
US20060129242A1 (en) Pseudo arthrosis device
WO1996024304A1 (en) Fixation method for the attachment of wound repair materials to cartilage defects
US20180049878A1 (en) Augments for bone deficiencies
WO2001017463A1 (en) Improved resorbable scaffolds to promote cartilage regeneration
EP1553898B1 (en) Use of snap-on semi annular augments to inhibit multi-directional instability after total hip arthroplasty
JP7335428B2 (en) An implant comprising a first set and a second set of pillars for attaching a tendon or ligament to hard tissue
JP2000513240A (en) Cartilage repair unit
AU693323C (en) Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
AU710212C (en) Fixation method for the attachment of wound repair materials to cartilage defects

Legal Events

Date Code Title Description
AS Assignment

Owner name: DEPUY PRODUCTS, INC., INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ORBAN, JANINE M.;SCHWARTZ, HERBERT E.;GROBE, NATHANIEL W.;REEL/FRAME:014776/0995;SIGNING DATES FROM 20031203 TO 20031204

Owner name: DEPUY PRODUCTS, INC.,INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ORBAN, JANINE M.;SCHWARTZ, HERBERT E.;GROBE, NATHANIEL W.;SIGNING DATES FROM 20031203 TO 20031204;REEL/FRAME:014776/0995

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
STCH Information on status: patent discontinuation

Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362

FP Lapsed due to failure to pay maintenance fee

Effective date: 20140223