US20050245889A1 - Disposable cassette - Google Patents

Disposable cassette Download PDF

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Publication number
US20050245889A1
US20050245889A1 US10/525,668 US52566805A US2005245889A1 US 20050245889 A1 US20050245889 A1 US 20050245889A1 US 52566805 A US52566805 A US 52566805A US 2005245889 A1 US2005245889 A1 US 2005245889A1
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United States
Prior art keywords
disposable cassette
accordance
actuators
channels
regions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/525,668
Inventor
Juergen Haecker
Stephan Frey
Uwe Lapp
Paul Jahn
Stephan Oesterreich
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Fresenius Medical Care Deutschland GmbH
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Individual
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Family has litigation
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Application filed by Individual filed Critical Individual
Assigned to FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH reassignment FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FREY, STEPHAN, JAHN, PAUL, HAECKER, JUERGEN, LAPP, UWE, OESTERREICH, STEPHAN
Publication of US20050245889A1 publication Critical patent/US20050245889A1/en
Priority to US12/805,124 priority Critical patent/US8202489B2/en
Abandoned legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/16Making multilayered or multicoloured articles
    • B29C45/1676Making multilayered or multicoloured articles using a soft material and a rigid material, e.g. making articles with a sealing part
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/0009Special features
    • F04B43/0054Special features particularities of the flexible members
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/02Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12Specific details about manufacturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/748Machines or parts thereof not otherwise provided for
    • B29L2031/7496Pumps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/748Machines or parts thereof not otherwise provided for
    • B29L2031/7506Valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/755Membranes, diaphragms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00148Test cards, e.g. Biomerieux or McDonnel multiwell test cards

Definitions

  • the invention relates to a disposable cassette in accordance with the preamble of claim 1 .
  • Disposable plastic articles with fluid carrying channels are frequently used in medical equipment.
  • Corresponding cassette systems have proven their worth here as alternatives to conventional hose systems.
  • the corresponding fluid paths are formed in these cassette systems.
  • the fluid flowing through the fluid paths is acted on by means of corresponding actuators.
  • valves are used via which the fluid paths are switched open or are closed.
  • pumps for the transport of the fluid are integrated in such cassette systems.
  • disposable cassettes are already known in which a rigid part is provided into which channels and chambers are formed. This rigid part is covered by a continuously flexible film.
  • the known cassette systems frequently have a very complex design. On the one hand, they have rigid boundaries and, on the other hand, they have regions for the installation of actuator elements.
  • the systems used in analysis technology are usually made in three layers in that, in addition to two rigid layers, a flexible film is also provided through which the fluid flow can be manipulated at exposed regions.
  • a generic disposable cassette for use in analysis technology is already known from WO 02/24320A1 which consists of a first part in which channel structures are cut-out in the surface. This first part is sealingly covered via a second part. One of the two parts is made as a flexible part. Engagement regions for actuator elements are provided at pre-determined points of this disposable cassette.
  • the forming of one of the two parts of the already known disposable cassette as a flexible part is, however, disadvantageous since the stability and also the functionality of the individual sealing function of the total disposable cassette is not always ensured.
  • the first part and/or the second part are, for the larger part, rigid in design.
  • respective flexibly designed regions can be provided, With the rigid and flexible regions each being manufactured in one piece using two-component injection molding technology.
  • the rigid part can thereby be manufactured as one component with the integrated flexible regions and can thus be manufactured in a cost-favorable manner in a single production step.
  • a high stability of the total component results here in comparison with the prior art.
  • a more compact design also results due to the fewer layers required with respect to other disposable cassettes of a more complex design in analysis technology.
  • the flexible regions can be formed in the engagement regions for the actuator elements.
  • At least some of the channels can consist of flexible material.
  • Valves, membrane pumps, restrictors or metering valves can be used as actuators.
  • the region of the channels in which the actuators are coupled is advantageously made shallower and with a larger channel cross-section.
  • the required actuator forces for the deflection of the flexible region can be reduced by these aspects.
  • Both liquids and gases can be the fluid for the flowing through of the channels.
  • the cassette in accordance with the invention is preferably used in medical engineering in the conveying and/or metering of fluids. It is particularly suitable for conveying and/or metering in analysis technology.
  • FIG. 1 a schematic, perspective detailed view of a partly sectioned disposable cassette in accordance with a variant of the present invention
  • FIG. 2 a schematic representation of the arrangement of different actuators along a channel in a disposable cassette in accordance with FIG. 1 ;
  • FIG. 3 a perspective representation of a further embodiment of the disposable cassette in accordance with the invention as a cut-out detail.
  • a channel structure 14 is formed for the purpose of fluid guidance in a first part 12 and is tightly closed by a second part 16 , a type of rigid cover plate.
  • a partial region 18 of the first part 12 which otherwise consists of a rigid plastic material, is made as an integral component of the part 12 in a flexible elastomer material.
  • This elastomer region 18 which is made in one piece, serves as a pump calotte.
  • the pump calotte is moved to and fro by being acted on by means of a corresponding actuator, which is not shown in more detail here in FIG. 1 , such that the space 20 sealingly surrounded by the pump calotte 18 is reduced or enlarged in volume.
  • This space 20 which is in communication with the channel 14 , is filled with the fluid to be conveyed so that the fluid can be conveyed accordingly by a corresponding deflection of the elastomer component 18 , i.e. the pump calotte.
  • This conveying principle corresponds precisely to that of a membrane pump and is already known as a principle both in analysis technology and overall in medical engineering.
  • valves 22 and 24 are provided at the inlet and outlet sides respectively in the channel 14 next to the flexible region 18 which serves as a pump calotte, said valves being attached as backflow valves which are closed and opened alternately in tact with the pump.
  • These regions can also be made as correspondingly flexible partial regions of the otherwise rigid first part 12 of the disposable cassette 10 .
  • the first part 12 can be produced as a one-piece element using two-component injection molding technology.
  • FIG. 3 Another embodiment variant of a disposable cassette 10 ′ is realized in FIG. 3 .
  • a channel structure 14 which is downwardly tightly closed by the second part 16 , which is made as a rigid cover plate, is formed in a first part 12 of the disposable cassette 10 ′ for the purpose of fluid guidance.
  • the channel 14 can be opened and closed in the flow direction by a channel section 30 which is made in a flexible elastomer material and which was manufactured in one piece with the first part 12 by two-component injection molding technology.
  • the resilient region 30 is an integral component of the otherwise rigid first part 12 due to this one-piece formation. It is thereby connected to it firmly, on the one hand, and in a liquid-tight manner, on the other hand.
  • the channel 14 is made continuously as a flexible elastomer part.
  • the channel can be made as a flexible elastomer part only in the region of the valve itself, while the other channel regions are formed by means of the rigid material of the first part 12 .
  • the force discharge onto the flexible elastomer region can take place in a variety of ways. On the one hand, in a tactile manner via a plunger 35 , as shown in FIG. 3 . On the other hand, however, also directly pneumatically via compressed air. In this case, a sealing lip would have to be provided around the valve on the rear side of the first part 12 .
  • the force can also be applied indirectly pneumatically or hydraulically via a small pressure cushion which would have to be provided on the instrument side. It is particularly advantageous here for a sealing function already being able to be achieved with very small valve closing forces.

Abstract

The invention relates to a disposable cassette, preferably for use in analysis technology, consisting of at least one first part in which channel structures are cut out in the surface and of a second part covering it in a sealing manner, with engagement regions for actuator elements being provided at pre-determined points. In accordance with the invention, the first part and/or the second part are made rigidly for the greater part; with them, however, having flexibly made regions, with the rigid and flexible regions being manufactured in one piece using two-component injection molding technology.

Description

  • The invention relates to a disposable cassette in accordance with the preamble of claim 1.
  • Disposable plastic articles with fluid carrying channels are frequently used in medical equipment. Corresponding cassette systems have proven their worth here as alternatives to conventional hose systems. The corresponding fluid paths are formed in these cassette systems. The fluid flowing through the fluid paths is acted on by means of corresponding actuators. For instance, valves are used via which the fluid paths are switched open or are closed. On the other hand, pumps for the transport of the fluid are integrated in such cassette systems. In the field of medical application, disposable cassettes are already known in which a rigid part is provided into which channels and chambers are formed. This rigid part is covered by a continuously flexible film.
  • In the field of analysis technology, the known cassette systems frequently have a very complex design. On the one hand, they have rigid boundaries and, on the other hand, they have regions for the installation of actuator elements. The systems used in analysis technology are usually made in three layers in that, in addition to two rigid layers, a flexible film is also provided through which the fluid flow can be manipulated at exposed regions.
  • A generic disposable cassette for use in analysis technology is already known from WO 02/24320A1 which consists of a first part in which channel structures are cut-out in the surface. This first part is sealingly covered via a second part. One of the two parts is made as a flexible part. Engagement regions for actuator elements are provided at pre-determined points of this disposable cassette. The forming of one of the two parts of the already known disposable cassette as a flexible part is, however, disadvantageous since the stability and also the functionality of the individual sealing function of the total disposable cassette is not always ensured.
  • It is therefore the object of the present invention to further develop a generic disposable cassette such that it has a simple design, on the one hand, and has a design stable per se, on the other hand.
  • This object is solved in accordance with the invention by a disposable cassette having the features of claim 1. Accordingly, the first part and/or the second part are, for the larger part, rigid in design. However, respective flexibly designed regions can be provided, With the rigid and flexible regions each being manufactured in one piece using two-component injection molding technology. The rigid part can thereby be manufactured as one component with the integrated flexible regions and can thus be manufactured in a cost-favorable manner in a single production step. On the other hand, a high stability of the total component results here in comparison with the prior art. A more compact design also results due to the fewer layers required with respect to other disposable cassettes of a more complex design in analysis technology.
  • Advantageous aspects of the invention are recited in the dependent claims.
  • Accordingly, the flexible regions can be formed in the engagement regions for the actuator elements.
  • On the other hand, at least some of the channels can consist of flexible material.
  • Valves, membrane pumps, restrictors or metering valves can be used as actuators.
  • The region of the channels in which the actuators are coupled is advantageously made shallower and with a larger channel cross-section. The required actuator forces for the deflection of the flexible region can be reduced by these aspects.
  • Both liquids and gases can be the fluid for the flowing through of the channels.
  • The cassette in accordance with the invention is preferably used in medical engineering in the conveying and/or metering of fluids. It is particularly suitable for conveying and/or metering in analysis technology.
  • Further details and advantages of the invention will be explained in more detail with reference to embodiments shown in the drawing. There are shown:
  • FIG. 1: a schematic, perspective detailed view of a partly sectioned disposable cassette in accordance with a variant of the present invention;
  • FIG. 2: a schematic representation of the arrangement of different actuators along a channel in a disposable cassette in accordance with FIG. 1; and
  • FIG. 3: a perspective representation of a further embodiment of the disposable cassette in accordance with the invention as a cut-out detail.
  • In the disposable cassette 10 shown partly in FIG. 1, a channel structure 14 is formed for the purpose of fluid guidance in a first part 12 and is tightly closed by a second part 16, a type of rigid cover plate. A partial region 18 of the first part 12, which otherwise consists of a rigid plastic material, is made as an integral component of the part 12 in a flexible elastomer material. This elastomer region 18, which is made in one piece, serves as a pump calotte. The pump calotte is moved to and fro by being acted on by means of a corresponding actuator, which is not shown in more detail here in FIG. 1, such that the space 20 sealingly surrounded by the pump calotte 18 is reduced or enlarged in volume. This space 20, which is in communication with the channel 14, is filled with the fluid to be conveyed so that the fluid can be conveyed accordingly by a corresponding deflection of the elastomer component 18, i.e. the pump calotte. This conveying principle corresponds precisely to that of a membrane pump and is already known as a principle both in analysis technology and overall in medical engineering. It is indicated in FIG. 2 that valves 22 and 24 are provided at the inlet and outlet sides respectively in the channel 14 next to the flexible region 18 which serves as a pump calotte, said valves being attached as backflow valves which are closed and opened alternately in tact with the pump. These regions can also be made as correspondingly flexible partial regions of the otherwise rigid first part 12 of the disposable cassette 10. The first part 12 can be produced as a one-piece element using two-component injection molding technology.
  • Another embodiment variant of a disposable cassette 10′ is realized in FIG. 3. A channel structure 14 which is downwardly tightly closed by the second part 16, which is made as a rigid cover plate, is formed in a first part 12 of the disposable cassette 10′ for the purpose of fluid guidance. The channel 14 can be opened and closed in the flow direction by a channel section 30 which is made in a flexible elastomer material and which was manufactured in one piece with the first part 12 by two-component injection molding technology. The resilient region 30 is an integral component of the otherwise rigid first part 12 due to this one-piece formation. It is thereby connected to it firmly, on the one hand, and in a liquid-tight manner, on the other hand.
  • It is sufficient for the closing of such a valve to guide the force of a plunger 35 to the rear side of the resilient region 30 in the direction a of the double arrow. The channel 14 is closed due to this force discharge. The opening of the valve takes place by removing the closing force, i.e. by the withdrawing of the plunger 35 in the direction a of the double arrow such that the region 30 is again shaped back into the original channel form by its resilient material properties
  • In the embodiment shown here, the channel 14 is made continuously as a flexible elastomer part. Alternatively to this, however, the channel can be made as a flexible elastomer part only in the region of the valve itself, while the other channel regions are formed by means of the rigid material of the first part 12. The force discharge onto the flexible elastomer region can take place in a variety of ways. On the one hand, in a tactile manner via a plunger 35, as shown in FIG. 3. On the other hand, however, also directly pneumatically via compressed air. In this case, a sealing lip would have to be provided around the valve on the rear side of the first part 12. Finally, the force can also be applied indirectly pneumatically or hydraulically via a small pressure cushion which would have to be provided on the instrument side. It is particularly advantageous here for a sealing function already being able to be achieved with very small valve closing forces.

Claims (19)

1. A disposable cassette consisting of at least one first part in which channel structures are cut out in the surface and of a second part covering it in a sealing manner, with engagement regions for actuator elements being provided at pre-determined points, characterized in that the first part and/or the second part are made rigidly for the greater part; in that they, however, have flexibly made regions, with the rigid and flexible regions being manufactured in one piece using two-component injection molding technology.
2. A disposable cassette in accordance with claim 1, wherein the flexible regions are formed in the engagement regions for the actuator elements.
3. A disposable cassette in accordance with claim 1, wherein at least some of the channels consist of flexible material.
4. A disposable cassette in accordance with claim 1, wherein valves are used as actuators.
5. A disposable cassette in accordance with claim 1, wherein membrane pumps are used as actuators.
6. A disposable cassette in accordance with claim 1, wherein restrictors or metering valves are used as actuators.
7. A disposable cassette in accordance with claim 1, wherein the region of the channels in which the actuators are coupled are made shallower and with a larger channel cross-section.
8. A disposable cassette in accordance with claim 2, wherein at least some of the channels consist of flexible material.
9. A disposable cassette in accordance with claim 2, wherein valves are used as actuators.
10. A disposable cassette in accordance with claim 3, wherein valves are used as actuators.
11. A disposable cassette in accordance with claim 2, wherein membrane pumps are used as actuators.
12. A disposable cassette in accordance with claim 3, wherein membrane pumps are used as actuators.
13. A disposable cassette in accordance with claim 2, wherein restrictors or metering valves are used as actuators.
14. A disposable cassette in accordance with claim 3, wherein restrictors or metering valves are used as actuators.
15. A disposable cassette in accordance with claim 2, wherein the region of the channels in which the actuators are coupled are made shallower and with a larger channel cross-section.
16. A disposable cassette in accordance with claim 3, wherein the region of the channels in which the actuators are coupled are made shallower and with a larger channel cross-section.
17. A disposable cassette in accordance with claim 4, wherein the region of the channels in which the actuators are coupled are made shallower and with a larger channel cross-section.
18. A disposable cassette in accordance with claim 5, wherein the region of the channels in which the actuators are coupled are made shallower and with a larger channel cross-section.
19. A disposable cassette in accordance with claim 6, wherein the region of the channels in which the actuators are coupled are made shallower and with a larger channel cross-section.
US10/525,668 2002-08-28 2003-08-18 Disposable cassette Abandoned US20050245889A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/805,124 US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10239597A DE10239597B4 (en) 2002-08-28 2002-08-28 disposable cartridge
DE10239597.7 2002-08-28
PCT/EP2003/009128 WO2004024326A1 (en) 2002-08-28 2003-08-18 Disposable cassette

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/805,124 Continuation US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Publications (1)

Publication Number Publication Date
US20050245889A1 true US20050245889A1 (en) 2005-11-03

Family

ID=31724146

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/525,668 Abandoned US20050245889A1 (en) 2002-08-28 2003-08-18 Disposable cassette
US12/805,124 Expired - Lifetime US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/805,124 Expired - Lifetime US8202489B2 (en) 2002-08-28 2010-07-13 Disposable cassette

Country Status (10)

Country Link
US (2) US20050245889A1 (en)
EP (1) EP1534431B1 (en)
JP (1) JP2006503204A (en)
KR (1) KR101057845B1 (en)
CN (2) CN1678396A (en)
AT (1) ATE423621T1 (en)
AU (1) AU2003282002A1 (en)
DE (2) DE10239597B4 (en)
ES (1) ES2319641T3 (en)
WO (1) WO2004024326A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
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US20060235335A1 (en) * 2005-03-30 2006-10-19 Roche Molecular Systems, Inc. Device having a self sealing fluid port
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CN110131141A (en) * 2019-03-03 2019-08-16 浙江师范大学 A kind of self-interacting type piezoelectricity medicine delivery pump easy to maintain

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US8202489B2 (en) 2012-06-19
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EP1534431B1 (en) 2009-02-25
EP1534431A1 (en) 2005-06-01

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