US20050251141A1 - Apparatus for connecting a bone fastener to a longitudinal rod - Google Patents
Apparatus for connecting a bone fastener to a longitudinal rod Download PDFInfo
- Publication number
- US20050251141A1 US20050251141A1 US11/182,677 US18267705A US2005251141A1 US 20050251141 A1 US20050251141 A1 US 20050251141A1 US 18267705 A US18267705 A US 18267705A US 2005251141 A1 US2005251141 A1 US 2005251141A1
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- United States
- Prior art keywords
- bore
- rod
- connector
- holding member
- bone fastener
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7044—Screws or hooks combined with longitudinal elements which do not contact vertebrae also having plates, staples or washers bearing on the vertebrae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
- A61B17/66—Alignment, compression or distraction mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7041—Screws or hooks combined with longitudinal elements which do not contact vertebrae with single longitudinal rod offset laterally from single row of screws or hooks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8033—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates having indirect contact with screw heads, or having contact with screw heads maintained with the aid of additional components, e.g. nuts, wedges or head covers
- A61B17/8038—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates having indirect contact with screw heads, or having contact with screw heads maintained with the aid of additional components, e.g. nuts, wedges or head covers the additional component being inserted in the screw head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8033—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates having indirect contact with screw heads, or having contact with screw heads maintained with the aid of additional components, e.g. nuts, wedges or head covers
- A61B17/8047—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates having indirect contact with screw heads, or having contact with screw heads maintained with the aid of additional components, e.g. nuts, wedges or head covers wherein the additional element surrounds the screw head in the plate hole
Definitions
- the invention relates to spinal fixation systems and, in particular, to a device for adjustably connecting a bone fastener to a longitudinal rod.
- pedicle screws or hooks are used to connect vertebral bodies to a longitudinal rod.
- the longitudinal rod Prior to implantation, the longitudinal rod is shaped in a particular form so as to correct the deformity of the vertebral column. This technique has proved successful and has been considered state of the art.
- the intra-operative connection of the two elements remains problematic, particularly in cases of heavy spinal deformities.
- the problem lies in the fixed distance between the head of the pedicle screw and the longitudinal carrier.
- the polyaxial bearing of the screw head within the connecting jaw allows for variable screw angles, but not for variable distances between the screw head and longitudinal rod carrier.
- a variable distance between the screw head or the end portion of the hook and the longitudinal rod carrier is desirable, because achieving 100 percent alignment of the vertebral column relative to the longitudinal rod is not always possible.
- the invention relates to a device for connecting a bone fastener to a longitudinal rod.
- the device comprises a connector that includes a coupling portion having two bores. Each bore has a longitudinal axis, and the axes are separated by a predetermined distance.
- the connector also has a holding member associated with the first bore configured to engage the bone fastener to connect the fastener to the coupling.
- a rod coupler is associated with the second bore and comprises a bore engaging portion, a rod receiving portion, and preferably a locking member having a rod coupler engaging portion.
- the connector is configured so the rod and rod coupler may be rotated about the first bore longitudinal axis.
- the holding member may be rotated about the second bore axis.
- the rod coupler may be rotated about the second bore longitudinal axis.
- the first and second bore axes are substantially parallel.
- the holding member may comprise top and bottom surfaces and a wall having at least one vertical slot, the slot intersecting either the top or bottom surface.
- the holding member may have a bore configured to engage a bone fastener, and may also have locked and unlocked positions.
- a tensioner may be provided to engage the holding member bore to lock the holding member, rendering the holding member immobilized with respect to the coupler first bore, and immobilizing the bone fastener within the holding member.
- the holding member and tensioner are configured so that when the tensioner engages the holding member to render it locked, the longitudinal rod and rod coupler may rotate 360 degrees within the second bore.
- the tensioner may comprise the head of a bone fastener such as a bone screw or pedicle hook.
- the holding member may comprise the head of a bone fastener.
- the coupling portion first bore may comprise a substantially spherical inner surface and the holding member may comprise a correspondingly substantially spherical outer surface configured to slide within the inner surface. This configuration allows the holding member to rotate within the first bore about multiple axes, which may include axes both parallel and perpendicular to the first bore axis.
- the holding member bore may have a conical profile and internal threads, and the tensioner may have a corresponding conical outer profile and external threads which mate with those of the bore.
- the holding member may be resiliently displaceable so that upon engagement with the tensioner, the holding member outer spherical surface may expand to engage the coupling first bore inner surface, configuring the holding member in the locked position.
- the holding member may have at least one slot configured to render the holding member resiliently displaceable.
- the rod receiving portion may have at least one vertical leg configured to accept the longitudinal rod, and the rod coupler may have locked and unlocked positions.
- the rod coupler and holding member may, independent of each other, be configured in their respective locked or unlocked positions.
- the rod receiving portion may comprise a channel having a longitudinal axis, a top distal from the bore engaging portion, and a bottom end opposite the top end.
- the channel longitudinal axis may be coaxial with that of the rod receiving portion.
- the top end of the channel may be open to allow a longitudinal rod to be introduced into the receiving portion by pressing the rod into the channel top end in a direction substantially parallel to the second bore axis.
- the rod coupler bore engaging portion may comprise a bottom end having an increased portion having a dimension greater than that of the second bore, preventing the rod coupler from passing all the way through the coupling when the coupler is inserted into the bore.
- This increased portion may comprise a conical flange, and the second bore may have a corresponding conical recess adjacent the bottom surface of the coupling.
- the conical flange and recess may have corresponding engagement surfaces, and at least one of the engagement surfaces may have serrations to prevent relative movement of the flange and coupling bore.
- An alternative embodiment of the connector may be provided for connecting a bone screw to a rod, the connector having a coupling with first and second bores separated by a predetermined distance, each bore having a longitudinal axis.
- a holding member may be associated with the first bore, and may be capable of engaging a bone screw.
- a rod coupler may be associated with the second bore, and may have a bore engaging portion and a rod receiving portion. The rod coupler may be rotatable about the second bore longitudinal axis.
- the holding member and coupling first bore may have corresponding spherical surfaces configured to allow the holding member to rotate within the first bore about multiple axes.
- the connector may also have a tensioner which may engage the holding member and immobilize the bone screw with respect to the holding member.
- the connector may be configured so that when the holding member engages the bone screw and the tensioner engages the holding member, and the rod coupler engages the longitudinal rod, the rod and rod coupler may be rotated 360 degrees within the second bore.
- the rod coupler may be provided with first and second vertical legs to receive a longitudinal rod.
- a rod locking member may also be provided to engage a top portion of each of the first and second legs to retain the rod within the rod coupler along a direction perpendicular to a longitudinal axis of the rod.
- the rod locking member may have threads which engage corresponding threads in the top portion of at least one of the first and second vertical legs of the rod coupler.
- the first and second legs may each have a top end distal from the coupling, where the top ends are open to allow a rod to be introduced into the rod receiving portion by pressing the rod between the legs in a direction substantially parallel to the second bore axis.
- the rod receiving portion of the rod coupler may form a channel configured to allow a rod to be introduced into the rod receiving portion by threading the rod into the channel in a direction substantially perpendicular to the second bore axis.
- the connector may also have a tensioner configured to engage the holding member to immobilize the bone screw with respect to the holding member.
- the holding member may be radially expandable so that when engaged by the tensioner, the holding member spherical surface expands to engage the inner surface of the coupling first bore, thus locking the holding member to the coupling.
- the rod locking member and rod coupler of this embodiment may be configured to engage the rod so that the rod may not move with respect to the rod coupler or rod locking member.
- the rod locking member and rod coupler may also be configured so that the rod is held between the rod locking member and a top surface of the connector.
- the rod coupler bore engaging portion may comprise a bottom end having an increased portion having a dimension greater than that of the second bore, wherein when the rod coupler is inserted into the second bore, the increased portion prevents the rod coupler from passing through the coupling.
- the increased portion may comprise a conical flange, and the second bore may have a corresponding conical recess adjacent to a bottom surface of the coupling.
- the conical flange and conical recess may have corresponding engaging surfaces, at least one of which may have serrations to prevent relative movement between the flange and bore.
- the rod coupler bore engaging portion may further comprise a top end opposite the bottom end, the bore engaging portion further may comprise a second increased portion located between the bore engaging portion top and bottom ends, the second increased portion having a dimension greater than that of the second bore, wherein when the rod coupler is inserted into the second bore, the first and second increased portions couple the rod coupler to the second bore.
- the rod coupler bore engaging portion may have at least one slot between the first and second increased portions, the at least one slot making at least part of the bore engaging portion resiliently displaceable to allow the second increase portion to be accepted within the second bore.
- a connector for connecting a bone screw to a rod has a coupling portion with first and second bores, each bore having a longitudinal axis, the axes separated by a predetermined distance.
- the first bore is associated with the bone screw
- the second bore is associated with a rod coupler.
- the rod coupler has an articulating portion and a rod receiving portion.
- the articulating portion is configured to be rotatably and axially slidably receivable within the second bore.
- the rod receiving portion has at least one vertical leg configured to receive the rod in a direction substantially perpendicular to the second bore longitudinal axis.
- the rod coupler may comprise a cap configured to engage the top end of the at least one vertical leg to retain the longitudinal rod in at least one direction perpendicular to the rod longitudinal axis.
- the connector of this embodiment may further comprise a holding member associated with the first bore and configured to receive the bone screw.
- the holding member may have a bore configured to accept the bone screw, the holding member further having an unlocked position in which it is free to rotate within the first bore, and a locked position in which it is immobilized within the first bore.
- a tensioner may be provided to engage the holding member and configure the holding member in the locked position whereby the holding member is immobilized within the first bore.
- the tensioner may comprise external threads configured to engage internal threads of the holding member bore.
- the connector is configured such that when the holding member engages the bone fastener, and the tensioner engages the holding member, and the rod coupler engages the rod, the rod and rod coupler may be rotated 360 degrees about both the first and second bore longitudinal axes.
- the first bore of the connector may have a substantially spherical inner surface and the holding member may have a substantially spherical outer surface configured to be slidably received within the first bore.
- the holding member may further be radially expandable such that when the tensioner engages the holding member bore, the holding member spherical outer surface expands to engage the inner spherical surface of the coupling first bore, thus locking the holding member to the coupling.
- the holding member bore may have a conical profile and internal threads
- the tensioner may have a conical outer profile and external threads corresponding to the holding member bore.
- the rod coupler may comprise a channel having a top end distal from the coupling portion and a bottom end proximal to the coupling portion, the channel top end being open to allow a rod having an axis substantially parallel to the channel axis to be introduced into the rod engaging portion by pressing the rod through the channel top end in a direction substantially parallel to the second bore axis.
- the connector articulating portion may comprise an increased portion having a dimension greater than that of the second bore, such that when the rod coupler is inserted into the second bore, the increased portion prevents the rod coupler from passing through the coupling.
- the increased portion may comprise a conical flange, and the second bore may have a corresponding conical recess adjacent to the coupling portion bottom surface.
- the conical flange and bore may have corresponding engagement surfaces, and at least one engagement surface comprises serrations to prevent relative rotation between the flange and bore.
- the holding member may have top and bottom surfaces and a wall.
- the wall may have at least one vertical slot intersecting at least the jaw top surface so that when the tensioner engages the holding member, the holding member expands along the at least one slot.
- FIG. 1 is an exploded view of a first embodiment of the invention
- FIG. 2 is a sectional view of a second embodiment of the invention of FIG. 1 , showing a fastener holding member formed integrally with a bone fastener, a tensioner, a holding member expansion feature, and a rod coupler;
- FIG. 3 is a sectional view of a third embodiment of the invention, showing the fastener holding member formed integrally with a pedicle hook;
- FIG. 4 is a sectional view of a fourth embodiment of the invention, showing an alternative arrangement of the longitudinal rod coupler.
- FIGS. 1 and 2 show a coupling 3 , a fastener holding member 10 , a tensioner 12 for releasably fixing a bone fastener 2 , a rod coupler 13 , and a rod locking element 33 configured for releasably fixing a longitudinal rod 1 to coupling 3 .
- Coupling 3 has a longitudinal axis 30 , a top surface 5 configured to contact longitudinal rod 1 , a bottom surface 6 , and a fastener coupling bore 7 which connects top and bottom surfaces 5 , 6 .
- Fastener coupling bore 7 further has an axis 11 that is substantially perpendicular to the coupling longitudinal axis 30 .
- coupling 3 has a rod coupling bore 19 which connects top and bottom surfaces 5 , 6 and has an axis 14 which is substantially parallel to fastener coupling bore axis 11 .
- the fastener and rod coupling bores 7 , 19 are separated by a distance 31 measured along the coupling longitudinal axis 30 .
- the rod coupling bore 19 is configured to slidingly receive a cylindrical articulating portion 130 of longitudinal rod coupler 13 such that coupler 13 may rotate within the bore 19 about the rod coupling bore axis 14 .
- the bottom end portion 16 of rod coupler 13 comprises an increased-diameter flange portion 35 , configured to mate with a corresponding recess 27 in the rod coupling bore 19 , so that when articulating portion 130 is inserted into the rod coupling bore 19 , the coupler flange portion 35 axially engages the rod coupler recess 27 , preventing further axial movement in the insertion direction of rod coupler 13 with respect to coupling 3 .
- the fastener coupling bore 7 may comprise a partial spherical profile, the top and bottom portions of the sphere being intersected and cut by coupling 3 top and bottom surfaces 5 , 6 .
- the fastener holding member 10 may have a partial spherical outer surface profile designed to correspond to the fastener coupling bore 7 inner surface. The corresponding spherical surfaces allow the fastener holding member 10 to be received in the fastener coupling bore 7 so that the holding member 10 is fully pivotable within the bore (i.e., it may rotate about any one of, or combination of, three orthogonal axes).
- the fastener holding member 10 may further comprise top and bottom surfaces 20 , 21 positioned adjacent top and bottom surfaces 5 , 6 respectively.
- Holding member 10 may further comprise a conical bore 23 having a conical internal screw thread 24 and an axis 230 that when installed is concentric to fastener coupling bore axis 11 .
- the fastener holding member 10 further may be configured so that its angular position within the fastener coupling bore 7 is lockable. Such a configuration may allow the user to lock the position of the associated fastener 2 in the desired pivot position, immobilizing it with respect to coupling 3 .
- This locking feature may be effected by providing a radial expansion feature within holding member 10 , so that when the desired holding member/fastener position is obtained at least a portion of the holding member 10 spherical surface may be expanded to contact or interfere with fastener coupling bore 7 , the frictional contact between surfaces preventing further relative movement.
- This radial expansion feature may be provided in the form of at least one vertical slot 101 located in holding member 10 between the holding member outer spherical surface and conical bore surface 23 .
- the at least one slot 101 may extend along a portion of the height of holding member 10 , and may be parallel to holding member bore axis 230 .
- the slot or slots 101 may intersect the top end surface 20 of holding member 10 , but not the bottom end surface 21 .
- the slot or slots 101 may intersect the bottom end surface 20 , but not the top end surface 21 .
- the fastener holding member 10 comprises a series of parallel vertical slots evenly spaced about the circumference of the holding member 10 , each slot intersecting one of the top or bottom end surfaces 20 , 21 of holding member 10 .
- a tensioner 12 may be provided to radially expand holding member 10 to its aforementioned locked position.
- the tensioner 12 may comprise a frustoconical outer surface 120 corresponding to the holding member conical bore 23 and further may be provided with a conical external screw thread 25 corresponding to the holding member bore threads 24 .
- the tensioner 12 may have an adjustment end 121 and a leading end 122 , the adjustment end 121 comprising a connection 123 suitable for engagement with a standard driving tool. Because the conical shape of tensioner 12 , adjustment end 121 has a larger outer diameter than leading end 122 .
- holding member 10 may be expanded by threadably driving the tensioner 12 into the bore so that the larger diameter adjustment end 121 enters a relatively smaller diameter portion of the holding member conical bore 23 , forcing open the at least one vertical slot 101 in the holding member 10 .
- Such expansion of the at least one slot 101 may be sufficient to press the holding member 10 outer surface against the fastener coupling bore 7 , fixing holding member 10 to coupling bore 7 and coupling 3 , as previously described.
- tensioner 12 itself comprises head portion 8 of bone fastener 2 .
- holding member 10 comprises head portion 8 of bone fastener 2 .
- Bone fastener 2 may be a bone screw 9 or a pedicle hook 90 .
- tensioner 12 is integral to head portion 8 of bone fastener 2
- bone fastener 2 may be releasably fixed to coupling 3 by threadably driving head portion 8 into holding member 10 , the corresponding conical surfaces 23 , 120 , threads 24 , 25 , and at least one slot 101 serving to expand holding member 10 and fix fastener 2 to the fastener coupling bore 7 .
- a longitudinal rod coupler 13 is used to receive and engage the longitudinal rod 1 .
- the rod coupler 13 may have an articulating portion 130 that is configured to be rotatable and axially slidable within rod coupling bore 19 , and which has an axis 131 that, when coupler 13 is engaged with coupling 3 , is substantially coaxial to the rod coupling bore axis 14 .
- Rod coupler 13 may also have a rod receiving portion 132 which, in one embodiment, comprises a channel 17 having a channel axis 32 oriented substantially perpendicular to the rod coupling bore axis 14 .
- Channel 17 may have at least one vertical leg 137 configured to retain the longitudinal rod in at least a direction substantially perpendicular to the rod longitudinal axis 4 .
- the longitudinal rod coupler 13 may have a top end 15 , adjacent to which channel 17 is open.
- the longitudinal rod coupler 13 may also have a bottom end 16 opposite the top end 15 , and adjacent to the coupling bottom surface 6 .
- the bottom end 16 may comprise an increased portion 35 having a diameter greater than the diameter of the rod coupling bore 19 , so that when the rod coupler 13 is inserted into the rod coupling bore 19 , the increased portion 35 prevents the rod coupler 13 from passing through the coupling bore 19 completely.
- the bottom surface 6 of the coupling 3 may comprise a corresponding recess 27 configured to engage the increased portion 35 .
- the increased portion may comprise a conical flange 26
- coupling 3 may comprise a correspondingly conical recess 27
- at least one of the conical flange 26 or coupling recess 27 , or both, may comprise serrations 28 .
- Channel 17 may be configured so that it is open at the top end 15 of the longitudinal rod coupler 13 .
- rod locking element 33 comprises a locking cap 133 .
- Cap 133 may comprise internal threads 134 configured to engage corresponding external threads 34 formed in the top end 15 of the rod coupler 13 .
- locking cap 133 may be threaded onto the coupler top end 15 and rotated until a bottom surface 135 of the cap engages the longitudinal rod 1 , thereby sandwiching longitudinal rod 1 between cap 133 and top surface 5 of coupling 3 .
- locking cap 133 may be unscrewed and disengaged from the rod coupler top end 15 .
- the portion of coupling 3 comprising fastener coupling bore 7 is recessed so that when a longitudinal rod 1 is engaged with coupling 3 , and a bone fastener 2 and tensioner 12 are fully engaged in holding member 10 , the fastener, tensioner and holding member are sufficiently recessed within coupling 3 that coupling 3 and rod 1 may be rotated without interference 360 degrees about the rod coupling bore axis 14 .
- FIG. 2 shows an alternative embodiment in which the fastener holding member 10 comprises the head portion 8 of bone fastener 2 , which, in this embodiment, is a bone screw 9 .
- the bottom end 16 of longitudinal rod coupler 13 comprises a conical flange 26 , configured to be received in a complementary inner cone 27 formed in the rod coupling bore 19 of coupling 3 .
- an at least partially circumferential tab segment 29 is provided on the rod coupler articulating portion adjacent the channel. This tab segment is adapted to engage the top surface 5 of coupling 3 when the rod coupler is inserted into the rod coupling bore 14 .
- the tab segment 29 When the tab segment 29 engages the top surface 5 of coupling 3 , it fixes rod coupler 13 axially with respect to coupling 3 and prevents rod coupler 13 from backing out of the rod coupling bore 19 .
- the inner diameter of the rod coupling bore 19 may be only slightly larger than the outer diameter of the articulating portion 130 .
- the articulation portion 130 may, therefore, comprise at least one vertical slot 36 to allow the articulating portion 130 to be compressed so that tab segment 29 can pass through the bottom surface 6 of the coupler and though the bore 19 .
- FIG. 3 shows an alternative embodiment of the rod coupler 13 in which the holding member 10 comprises the head portion 8 of the bone fastener 2 , which, in this embodiment, is a pedicle hook 90 .
- the head portion of the pedicle hook 90 comprises the spherically-shaped holding member 10 .
- FIG. 4 shows a further embodiment of the coupling 3 in which channel 17 is open at the top end 15 to permit a longitudinal rod 1 to be inserted laterally into the longitudinal rod coupler 13 (i.e. in a direction perpendicular to the rod longitudinal axis 4 ).
- a sleeve 360 including a rod engaging surface 361 , and two side walls 37 extending parallel to the rod coupling bore axis 14 , is placed over the rod receiving portion 132 (in this case channel 17 ) at the top end 15 to fix the longitudinal rod 1 relative to the longitudinal rod coupler 13 .
- the sleeve 360 is then held in place by a nut 38 which may be screwed onto an external screw thread 34 on the channel top end 15 .
- conical flange 26 comprises radially aligned teeth (e.g., serrations 28 ), which secure rod coupler 13 and coupling 3 against relative rotational movement.
Abstract
Description
- This is a continuation of co-pending U.S. application Ser. No. 10/372,345, filed Feb. 24, 2003, now U.S. Pat. No. ______, which is a continuation of International Patent Application No. PCT/CH00/00449, filed Aug. 24, 2000, the entire contents of both are expressly incorporated herein by reference thereto.
- The invention relates to spinal fixation systems and, in particular, to a device for adjustably connecting a bone fastener to a longitudinal rod.
- In posterior treatment of spinal deformities, pedicle screws or hooks are used to connect vertebral bodies to a longitudinal rod. Prior to implantation, the longitudinal rod is shaped in a particular form so as to correct the deformity of the vertebral column. This technique has proved successful and has been considered state of the art.
- Despite the development of new connecting techniques, such as the use of jaws with polyaxial bearings to connect the screws and the longitudinal rod, the intra-operative connection of the two elements remains problematic, particularly in cases of heavy spinal deformities. The problem lies in the fixed distance between the head of the pedicle screw and the longitudinal carrier. In other words, the polyaxial bearing of the screw head within the connecting jaw allows for variable screw angles, but not for variable distances between the screw head and longitudinal rod carrier. A variable distance between the screw head or the end portion of the hook and the longitudinal rod carrier is desirable, because achieving 100 percent alignment of the vertebral column relative to the longitudinal rod is not always possible.
- It is accordingly an object of the invention to provide an apparatus for connecting a pedicle screw or a pedicle hook to a longitudinal rod that has a polyaxial bearing for the pedicle screw or pedicle hook and a pivotable connection between the connector and the longitudinal rod that can be locked in any desired position.
- The invention relates to a device for connecting a bone fastener to a longitudinal rod. The device comprises a connector that includes a coupling portion having two bores. Each bore has a longitudinal axis, and the axes are separated by a predetermined distance. The connector also has a holding member associated with the first bore configured to engage the bone fastener to connect the fastener to the coupling. A rod coupler is associated with the second bore and comprises a bore engaging portion, a rod receiving portion, and preferably a locking member having a rod coupler engaging portion. The connector is configured so the rod and rod coupler may be rotated about the first bore longitudinal axis. In one embodiment, the holding member may be rotated about the second bore axis. In another embodiment, the rod coupler may be rotated about the second bore longitudinal axis. In yet another embodiment, the first and second bore axes are substantially parallel.
- The holding member may comprise top and bottom surfaces and a wall having at least one vertical slot, the slot intersecting either the top or bottom surface. The holding member may have a bore configured to engage a bone fastener, and may also have locked and unlocked positions. A tensioner may be provided to engage the holding member bore to lock the holding member, rendering the holding member immobilized with respect to the coupler first bore, and immobilizing the bone fastener within the holding member.
- The holding member and tensioner are configured so that when the tensioner engages the holding member to render it locked, the longitudinal rod and rod coupler may rotate 360 degrees within the second bore. In one embodiment, the tensioner may comprise the head of a bone fastener such as a bone screw or pedicle hook. Alternatively, the holding member may comprise the head of a bone fastener.
- The coupling portion first bore may comprise a substantially spherical inner surface and the holding member may comprise a correspondingly substantially spherical outer surface configured to slide within the inner surface. This configuration allows the holding member to rotate within the first bore about multiple axes, which may include axes both parallel and perpendicular to the first bore axis.
- The holding member bore may have a conical profile and internal threads, and the tensioner may have a corresponding conical outer profile and external threads which mate with those of the bore. The holding member may be resiliently displaceable so that upon engagement with the tensioner, the holding member outer spherical surface may expand to engage the coupling first bore inner surface, configuring the holding member in the locked position. The holding member may have at least one slot configured to render the holding member resiliently displaceable.
- The rod receiving portion may have at least one vertical leg configured to accept the longitudinal rod, and the rod coupler may have locked and unlocked positions. The rod coupler and holding member may, independent of each other, be configured in their respective locked or unlocked positions.
- The rod receiving portion may comprise a channel having a longitudinal axis, a top distal from the bore engaging portion, and a bottom end opposite the top end. The channel longitudinal axis may be coaxial with that of the rod receiving portion. The top end of the channel may be open to allow a longitudinal rod to be introduced into the receiving portion by pressing the rod into the channel top end in a direction substantially parallel to the second bore axis.
- The rod coupler bore engaging portion may comprise a bottom end having an increased portion having a dimension greater than that of the second bore, preventing the rod coupler from passing all the way through the coupling when the coupler is inserted into the bore. This increased portion may comprise a conical flange, and the second bore may have a corresponding conical recess adjacent the bottom surface of the coupling. The conical flange and recess may have corresponding engagement surfaces, and at least one of the engagement surfaces may have serrations to prevent relative movement of the flange and coupling bore.
- An alternative embodiment of the connector may be provided for connecting a bone screw to a rod, the connector having a coupling with first and second bores separated by a predetermined distance, each bore having a longitudinal axis. A holding member may be associated with the first bore, and may be capable of engaging a bone screw. A rod coupler may be associated with the second bore, and may have a bore engaging portion and a rod receiving portion. The rod coupler may be rotatable about the second bore longitudinal axis.
- The holding member and coupling first bore may have corresponding spherical surfaces configured to allow the holding member to rotate within the first bore about multiple axes.
- The connector may also have a tensioner which may engage the holding member and immobilize the bone screw with respect to the holding member. The connector may be configured so that when the holding member engages the bone screw and the tensioner engages the holding member, and the rod coupler engages the longitudinal rod, the rod and rod coupler may be rotated 360 degrees within the second bore.
- The rod coupler may be provided with first and second vertical legs to receive a longitudinal rod. A rod locking member may also be provided to engage a top portion of each of the first and second legs to retain the rod within the rod coupler along a direction perpendicular to a longitudinal axis of the rod. The rod locking member may have threads which engage corresponding threads in the top portion of at least one of the first and second vertical legs of the rod coupler.
- The first and second legs may each have a top end distal from the coupling, where the top ends are open to allow a rod to be introduced into the rod receiving portion by pressing the rod between the legs in a direction substantially parallel to the second bore axis. The rod receiving portion of the rod coupler may form a channel configured to allow a rod to be introduced into the rod receiving portion by threading the rod into the channel in a direction substantially perpendicular to the second bore axis.
- The connector may also have a tensioner configured to engage the holding member to immobilize the bone screw with respect to the holding member. The holding member may be radially expandable so that when engaged by the tensioner, the holding member spherical surface expands to engage the inner surface of the coupling first bore, thus locking the holding member to the coupling.
- The rod locking member and rod coupler of this embodiment may be configured to engage the rod so that the rod may not move with respect to the rod coupler or rod locking member. The rod locking member and rod coupler may also be configured so that the rod is held between the rod locking member and a top surface of the connector. The rod coupler bore engaging portion may comprise a bottom end having an increased portion having a dimension greater than that of the second bore, wherein when the rod coupler is inserted into the second bore, the increased portion prevents the rod coupler from passing through the coupling. The increased portion may comprise a conical flange, and the second bore may have a corresponding conical recess adjacent to a bottom surface of the coupling. The conical flange and conical recess may have corresponding engaging surfaces, at least one of which may have serrations to prevent relative movement between the flange and bore.
- The rod coupler bore engaging portion may further comprise a top end opposite the bottom end, the bore engaging portion further may comprise a second increased portion located between the bore engaging portion top and bottom ends, the second increased portion having a dimension greater than that of the second bore, wherein when the rod coupler is inserted into the second bore, the first and second increased portions couple the rod coupler to the second bore. The rod coupler bore engaging portion may have at least one slot between the first and second increased portions, the at least one slot making at least part of the bore engaging portion resiliently displaceable to allow the second increase portion to be accepted within the second bore.
- In yet another embodiment of the invention, a connector for connecting a bone screw to a rod has a coupling portion with first and second bores, each bore having a longitudinal axis, the axes separated by a predetermined distance. The first bore is associated with the bone screw, and the second bore is associated with a rod coupler. The rod coupler has an articulating portion and a rod receiving portion. The articulating portion is configured to be rotatably and axially slidably receivable within the second bore. The rod receiving portion has at least one vertical leg configured to receive the rod in a direction substantially perpendicular to the second bore longitudinal axis. When the rod engages the rod coupler, the rod may be selectively rotated about the first bore longitudinal axis. The rod coupler may comprise a cap configured to engage the top end of the at least one vertical leg to retain the longitudinal rod in at least one direction perpendicular to the rod longitudinal axis.
- The connector of this embodiment may further comprise a holding member associated with the first bore and configured to receive the bone screw. The holding member may have a bore configured to accept the bone screw, the holding member further having an unlocked position in which it is free to rotate within the first bore, and a locked position in which it is immobilized within the first bore. A tensioner may be provided to engage the holding member and configure the holding member in the locked position whereby the holding member is immobilized within the first bore. The tensioner may comprise external threads configured to engage internal threads of the holding member bore.
- The connector is configured such that when the holding member engages the bone fastener, and the tensioner engages the holding member, and the rod coupler engages the rod, the rod and rod coupler may be rotated 360 degrees about both the first and second bore longitudinal axes.
- The first bore of the connector may have a substantially spherical inner surface and the holding member may have a substantially spherical outer surface configured to be slidably received within the first bore. The holding member may further be radially expandable such that when the tensioner engages the holding member bore, the holding member spherical outer surface expands to engage the inner spherical surface of the coupling first bore, thus locking the holding member to the coupling.
- The holding member bore may have a conical profile and internal threads, and the tensioner may have a conical outer profile and external threads corresponding to the holding member bore.
- The rod coupler may comprise a channel having a top end distal from the coupling portion and a bottom end proximal to the coupling portion, the channel top end being open to allow a rod having an axis substantially parallel to the channel axis to be introduced into the rod engaging portion by pressing the rod through the channel top end in a direction substantially parallel to the second bore axis.
- The connector articulating portion may comprise an increased portion having a dimension greater than that of the second bore, such that when the rod coupler is inserted into the second bore, the increased portion prevents the rod coupler from passing through the coupling. The increased portion may comprise a conical flange, and the second bore may have a corresponding conical recess adjacent to the coupling portion bottom surface. The conical flange and bore may have corresponding engagement surfaces, and at least one engagement surface comprises serrations to prevent relative rotation between the flange and bore.
- The holding member may have top and bottom surfaces and a wall. The wall may have at least one vertical slot intersecting at least the jaw top surface so that when the tensioner engages the holding member, the holding member expands along the at least one slot.
- The features and advantages of the invention will become more apparent upon consideration of the following detailed description, taken in conjunction with the accompanying drawings, in which like reference characters refer to like parts throughout, and in which:
-
FIG. 1 is an exploded view of a first embodiment of the invention; -
FIG. 2 is a sectional view of a second embodiment of the invention ofFIG. 1 , showing a fastener holding member formed integrally with a bone fastener, a tensioner, a holding member expansion feature, and a rod coupler; -
FIG. 3 is a sectional view of a third embodiment of the invention, showing the fastener holding member formed integrally with a pedicle hook; and -
FIG. 4 is a sectional view of a fourth embodiment of the invention, showing an alternative arrangement of the longitudinal rod coupler. -
FIGS. 1 and 2 show acoupling 3, afastener holding member 10, atensioner 12 for releasably fixing abone fastener 2, arod coupler 13, and arod locking element 33 configured for releasably fixing alongitudinal rod 1 tocoupling 3.Coupling 3 has alongitudinal axis 30, atop surface 5 configured to contactlongitudinal rod 1, abottom surface 6, and a fastener coupling bore 7 which connects top andbottom surfaces axis 11 that is substantially perpendicular to the couplinglongitudinal axis 30. In addition,coupling 3 has a rod coupling bore 19 which connects top andbottom surfaces axis 14 which is substantially parallel to fastener coupling boreaxis 11. The fastener and rod coupling bores 7, 19 are separated by adistance 31 measured along the couplinglongitudinal axis 30. - The rod coupling bore 19 is configured to slidingly receive a cylindrical articulating
portion 130 oflongitudinal rod coupler 13 such thatcoupler 13 may rotate within thebore 19 about the rod coupling boreaxis 14. Thebottom end portion 16 ofrod coupler 13 comprises an increased-diameter flange portion 35, configured to mate with acorresponding recess 27 in the rod coupling bore 19, so that when articulatingportion 130 is inserted into the rod coupling bore 19, thecoupler flange portion 35 axially engages therod coupler recess 27, preventing further axial movement in the insertion direction ofrod coupler 13 with respect tocoupling 3. - The fastener coupling bore 7 may comprise a partial spherical profile, the top and bottom portions of the sphere being intersected and cut by coupling 3 top and
bottom surfaces fastener holding member 10 may have a partial spherical outer surface profile designed to correspond to the fastener coupling bore 7 inner surface. The corresponding spherical surfaces allow thefastener holding member 10 to be received in the fastener coupling bore 7 so that the holdingmember 10 is fully pivotable within the bore (i.e., it may rotate about any one of, or combination of, three orthogonal axes). - The
fastener holding member 10 may further comprise top andbottom surfaces bottom surfaces member 10 may further comprise aconical bore 23 having a conicalinternal screw thread 24 and anaxis 230 that when installed is concentric to fastener coupling boreaxis 11. - The
fastener holding member 10 further may be configured so that its angular position within the fastener coupling bore 7 is lockable. Such a configuration may allow the user to lock the position of the associatedfastener 2 in the desired pivot position, immobilizing it with respect tocoupling 3. This locking feature may be effected by providing a radial expansion feature within holdingmember 10, so that when the desired holding member/fastener position is obtained at least a portion of the holdingmember 10 spherical surface may be expanded to contact or interfere withfastener coupling bore 7, the frictional contact between surfaces preventing further relative movement. This radial expansion feature may be provided in the form of at least onevertical slot 101 located in holdingmember 10 between the holding member outer spherical surface andconical bore surface 23. The at least oneslot 101 may extend along a portion of the height of holdingmember 10, and may be parallel to holding member boreaxis 230. The slot orslots 101 may intersect thetop end surface 20 of holdingmember 10, but not thebottom end surface 21. Alternatively, the slot orslots 101 may intersect thebottom end surface 20, but not thetop end surface 21. In one embodiment, thefastener holding member 10 comprises a series of parallel vertical slots evenly spaced about the circumference of the holdingmember 10, each slot intersecting one of the top or bottom end surfaces 20, 21 of holdingmember 10. - A
tensioner 12 may be provided to radially expand holdingmember 10 to its aforementioned locked position. Thetensioner 12 may comprise a frustoconicalouter surface 120 corresponding to the holding member conical bore 23 and further may be provided with a conicalexternal screw thread 25 corresponding to the holding member borethreads 24. Thetensioner 12 may have anadjustment end 121 and aleading end 122, theadjustment end 121 comprising aconnection 123 suitable for engagement with a standard driving tool. Because the conical shape oftensioner 12,adjustment end 121 has a larger outer diameter than leadingend 122. Under this arrangement, holdingmember 10 may be expanded by threadably driving thetensioner 12 into the bore so that the largerdiameter adjustment end 121 enters a relatively smaller diameter portion of the holding member conical bore 23, forcing open the at least onevertical slot 101 in the holdingmember 10. Such expansion of the at least oneslot 101 may be sufficient to press the holdingmember 10 outer surface against thefastener coupling bore 7, fixing holdingmember 10 tocoupling bore 7 andcoupling 3, as previously described. - In one embodiment,
tensioner 12 itself compriseshead portion 8 ofbone fastener 2. In an alternative embodiment, holdingmember 10 compriseshead portion 8 ofbone fastener 2.Bone fastener 2 may be abone screw 9 or apedicle hook 90. Wheretensioner 12 is integral tohead portion 8 ofbone fastener 2,bone fastener 2 may be releasably fixed tocoupling 3 by threadably drivinghead portion 8 into holdingmember 10, the correspondingconical surfaces threads slot 101 serving to expand holdingmember 10 and fixfastener 2 to thefastener coupling bore 7. - A
longitudinal rod coupler 13 is used to receive and engage thelongitudinal rod 1. Therod coupler 13 may have an articulatingportion 130 that is configured to be rotatable and axially slidable within rod coupling bore 19, and which has anaxis 131 that, whencoupler 13 is engaged withcoupling 3, is substantially coaxial to the rod coupling boreaxis 14.Rod coupler 13 may also have arod receiving portion 132 which, in one embodiment, comprises achannel 17 having achannel axis 32 oriented substantially perpendicular to the rod coupling boreaxis 14.Channel 17 may have at least onevertical leg 137 configured to retain the longitudinal rod in at least a direction substantially perpendicular to the rodlongitudinal axis 4. - The
longitudinal rod coupler 13 may have atop end 15, adjacent to whichchannel 17 is open. Thelongitudinal rod coupler 13 may also have abottom end 16 opposite thetop end 15, and adjacent to thecoupling bottom surface 6. Thebottom end 16 may comprise an increasedportion 35 having a diameter greater than the diameter of the rod coupling bore 19, so that when therod coupler 13 is inserted into the rod coupling bore 19, the increasedportion 35 prevents therod coupler 13 from passing through the coupling bore 19 completely. Where thebottom end 16 comprises an increasedportion 35, thebottom surface 6 of thecoupling 3 may comprise acorresponding recess 27 configured to engage the increasedportion 35. In one embodiment, the increased portion may comprise aconical flange 26, andcoupling 3 may comprise a correspondinglyconical recess 27. To prevent post-installation rotation betweencoupling 3 androd coupler 13, at least one of theconical flange 26 orcoupling recess 27, or both, may comprise serrations 28. -
Channel 17 may be configured so that it is open at thetop end 15 of thelongitudinal rod coupler 13. To capture thelongitudinal rod 1 within therod coupler channel 17, arod locking element 33 may be provided. In one embodiment,rod locking element 33 comprises alocking cap 133.Cap 133 may compriseinternal threads 134 configured to engage correspondingexternal threads 34 formed in thetop end 15 of therod coupler 13. Upon insertion of thelongitudinal rod 1 in thechannel 17, lockingcap 133 may be threaded onto the couplertop end 15 and rotated until abottom surface 135 of the cap engages thelongitudinal rod 1, thereby sandwichinglongitudinal rod 1 betweencap 133 andtop surface 5 ofcoupling 3. To releaselongitudinal rod 1, lockingcap 133 may be unscrewed and disengaged from the rod couplertop end 15. - In one embodiment, the portion of
coupling 3 comprising fastener coupling bore 7 is recessed so that when alongitudinal rod 1 is engaged withcoupling 3, and abone fastener 2 andtensioner 12 are fully engaged in holdingmember 10, the fastener, tensioner and holding member are sufficiently recessed withincoupling 3 thatcoupling 3 androd 1 may be rotated withoutinterference 360 degrees about the rod coupling boreaxis 14. -
FIG. 2 shows an alternative embodiment in which thefastener holding member 10 comprises thehead portion 8 ofbone fastener 2, which, in this embodiment, is abone screw 9. In this embodiment, thebottom end 16 oflongitudinal rod coupler 13 comprises aconical flange 26, configured to be received in a complementaryinner cone 27 formed in the rod coupling bore 19 ofcoupling 3. Additionally, an at least partiallycircumferential tab segment 29 is provided on the rod coupler articulating portion adjacent the channel. This tab segment is adapted to engage thetop surface 5 ofcoupling 3 when the rod coupler is inserted into the rod coupling bore 14. When thetab segment 29 engages thetop surface 5 ofcoupling 3, it fixesrod coupler 13 axially with respect tocoupling 3 and preventsrod coupler 13 from backing out of the rod coupling bore 19. The inner diameter of the rod coupling bore 19 may be only slightly larger than the outer diameter of the articulatingportion 130. Thearticulation portion 130 may, therefore, comprise at least onevertical slot 36 to allow the articulatingportion 130 to be compressed so thattab segment 29 can pass through thebottom surface 6 of the coupler and though thebore 19. -
FIG. 3 shows an alternative embodiment of therod coupler 13 in which the holdingmember 10 comprises thehead portion 8 of thebone fastener 2, which, in this embodiment, is apedicle hook 90. In this embodiment the head portion of thepedicle hook 90 comprises the spherically-shaped holdingmember 10. -
FIG. 4 shows a further embodiment of thecoupling 3 in which channel 17 is open at thetop end 15 to permit alongitudinal rod 1 to be inserted laterally into the longitudinal rod coupler 13 (i.e. in a direction perpendicular to the rod longitudinal axis 4). Asleeve 360, including arod engaging surface 361, and twoside walls 37 extending parallel to the rod coupling boreaxis 14, is placed over the rod receiving portion 132 (in this case channel 17) at thetop end 15 to fix thelongitudinal rod 1 relative to thelongitudinal rod coupler 13. Thesleeve 360 is then held in place by anut 38 which may be screwed onto anexternal screw thread 34 on the channeltop end 15. Thus thelongitudinal rod 1 is retained between thetop surface 5 ofcoupling 3 androd engaging surface 361 of thesleeve 360. Theside walls 37 provide lateral fixation. In this embodiment,conical flange 26 comprises radially aligned teeth (e.g., serrations 28), whichsecure rod coupler 13 andcoupling 3 against relative rotational movement. - Accordingly, it should be understood that the embodiments disclosed herein are merely illustrative of the principles of the invention. Various other modifications may be made by those skilled in the art that will embody the principles of the invention and fall within the spirit and the scope thereof.
Claims (34)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/182,677 US20050251141A1 (en) | 2000-08-24 | 2005-07-15 | Apparatus for connecting a bone fastener to a longitudinal rod |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CH2000/000449 WO2002015806A1 (en) | 2000-08-24 | 2000-08-24 | Device for connecting a bone fixation element to a longitudinal rod |
US10/372,345 US6945972B2 (en) | 2000-08-24 | 2003-02-24 | Apparatus for connecting a bone fastener to a longitudinal rod |
US11/182,677 US20050251141A1 (en) | 2000-08-24 | 2005-07-15 | Apparatus for connecting a bone fastener to a longitudinal rod |
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Application Number | Title | Priority Date | Filing Date |
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US10/372,345 Continuation US6945972B2 (en) | 2000-08-24 | 2003-02-24 | Apparatus for connecting a bone fastener to a longitudinal rod |
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US20050251141A1 true US20050251141A1 (en) | 2005-11-10 |
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US10/372,345 Expired - Lifetime US6945972B2 (en) | 2000-08-24 | 2003-02-24 | Apparatus for connecting a bone fastener to a longitudinal rod |
US11/182,677 Abandoned US20050251141A1 (en) | 2000-08-24 | 2005-07-15 | Apparatus for connecting a bone fastener to a longitudinal rod |
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Application Number | Title | Priority Date | Filing Date |
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US10/372,345 Expired - Lifetime US6945972B2 (en) | 2000-08-24 | 2003-02-24 | Apparatus for connecting a bone fastener to a longitudinal rod |
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US (2) | US6945972B2 (en) |
EP (1) | EP1311198B1 (en) |
JP (1) | JP2004505745A (en) |
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CN (1) | CN1247162C (en) |
AR (1) | AR030330A1 (en) |
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Also Published As
Publication number | Publication date |
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TW565436B (en) | 2003-12-11 |
WO2002015806A1 (en) | 2002-02-28 |
ATE367773T1 (en) | 2007-08-15 |
EP1311198B1 (en) | 2007-07-25 |
US6945972B2 (en) | 2005-09-20 |
EP1311198A1 (en) | 2003-05-21 |
CN1247162C (en) | 2006-03-29 |
BR0017321A (en) | 2003-07-29 |
KR20030026351A (en) | 2003-03-31 |
MXPA03001628A (en) | 2003-06-24 |
JP2004505745A (en) | 2004-02-26 |
MY124899A (en) | 2006-07-31 |
AU6423300A (en) | 2002-03-04 |
CN1454070A (en) | 2003-11-05 |
DE50014519D1 (en) | 2007-09-06 |
AU2000264233B2 (en) | 2004-04-29 |
ES2288864T3 (en) | 2008-02-01 |
US20030149432A1 (en) | 2003-08-07 |
KR100773965B1 (en) | 2007-11-08 |
AR030330A1 (en) | 2003-08-20 |
CA2419798A1 (en) | 2002-02-28 |
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