US20070043397A1 - Cardiac mapping instrument with shapeable electrode - Google Patents
Cardiac mapping instrument with shapeable electrode Download PDFInfo
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- US20070043397A1 US20070043397A1 US11/586,112 US58611206A US2007043397A1 US 20070043397 A1 US20070043397 A1 US 20070043397A1 US 58611206 A US58611206 A US 58611206A US 2007043397 A1 US2007043397 A1 US 2007043397A1
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- shaft
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
- A61B2017/2926—Details of heads or jaws
- A61B2017/2927—Details of heads or jaws the angular position of the head being adjustable with respect to the shaft
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1472—Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
Abstract
An instrument including an elongated shaft and a non-conductive handle is disclosed. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive tip. Further, the shaft is adapted to be transitionable from a straight state to a first bent state. The shaft is capable of independently maintaining the distinct shapes associated with the straight state and the first bent state. The handle is rigidly coupled to the proximal section of the shaft. The instrument is useful for epicardial pacing and/or mapping of the heart for temporary pacing on a beating heart, for optimizing the placement of ventricular leads for the treatment of patients with congestive heart failure and ventricular dysynchrony and/or for use in surgical ablation procedures.
Description
- This application is a continuation-in-part of U.S. Ser. No. 10/056,807 filed Jan. 25, 2002, the disclosure of which is incorporated herein by reference.
- This invention relates to methods and systems for epicardial pacing and mapping of the heart for temporary pacing on a beating heart, for optimizing the placement of ventricular leads for the treatment of patients with congestive heart failure and ventricular dysynchrony or for use in surgical ablation procedures. More particularly, it relates to a mapping instrument designed to be indifferent to rotational orientation and including a bendable shaft capable of independently maintaining a desired shape.
- The heart includes a number of pathways that are responsible for the propagation of signals necessary to produce continuous, synchronized contractions. Each contraction cycle begins in the right atrium where a sinoatrial node initiates an electrical impulse. This impulse then spreads across the right atrium to the left atrium, stimulating the atria to contract. The chain reaction continues from the atria to the ventricles by passing through a pathway known as the atrioventricular (AV) node or junction, which acts as an electrical gateway to the ventricles. The AV junction delivers the signal to the ventricles while also slowing it, so the atria can relax before the ventricles contract.
- Disturbances in the heart's electrical system may lead to various rhythmic problems that can cause the heart to beat irregularly, too fast or too slow. Irregular heart beats, or arrhythmia, are caused by physiological or pathological disturbances in the discharge of electrical impulses from the sinoatrial node, in the transmission of the signal through the heart tissue, or spontaneous, unexpected electrical signals generated within the heart. One type of arrhythmia is tachycardia, which is an abnormal rapidity of heart action. There are several different forms of atrial tachycardia, including atrial fibrillation and atrial flutter. With atrial fibrillation, instead of a single beat, numerous electrical impulses are generated by depolarizing tissue at one or more locations in the atria (or possibly other locations). These unexpected electrical impulses produce irregular, often rapid heartbeats in the atrial muscles and ventricles. Patients experiencing atrial fibrillation may suffer from fatigue, activity intolerance, dizziness and even strokes.
- The precise cause of atrial fibrillation, and in particular the depolarizing tissue causing “extra” electrical signals, is currently unknown. As to the location of the depolarizing tissue, it is generally agreed that the undesired electrical impulses often originate in the left atrial region of the heart. Recent studies have expanded upon this general understanding, suggesting that nearly 90% of these “focal triggers” or electrical impulses are generated in one (or more) of the four pulmonary veins (PV) extending from the left atrium. In this regard, as the heart develops from an embryotic stage, left atrium tissue may grow or extend a short distance into one or more of the PVs. It has been postulated that this tissue may spontaneously depolarize, resulting in an unexpected electrical impulse(s) propagating into the left atrium and along the various electrical pathways of the heart.
- A variety of different atrial fibrillation treatment techniques are available, including drugs, surgery, implants, and ablation. While drugs may be the treatment of choice for some patients, drugs typically only mask the symptoms and do not cure the underlying cause. Implantable devices, on the other hand, usually correct an arrhythmia only after it occurs. Surgical and ablation treatments, in contrast, can actually cure the problem by removing and/or ablating the abnormal tissue or accessory pathway responsible for the atrial fibrillation. The ablation treatments rely on the application of various destructive energy sources to the target tissue, including direct current electrical energy, radiofrequency electrical energy, laser energy, microwave energy, ultrasound energy, thermal energy, and the like. The energy source, such as an ablating electrode, is normally disposed along a distal portion of a catheter or instrument. Ablation of the abnormal tissue or accessory pathway responsible for atrial fibrillation has proven highly viable.
- Regardless of the application, ablation of tissue is generally achieved by applying the destructive energy source to the target tissue. For some treatments, an ablating element can be formed as a part of a catheter that is delivered via the vascular system to the target site. While relatively non-invasive, catheter-based treatments present certain obstacles to achieving precisely located, complete ablation lesion patterns due to the highly flexible nature of the catheter itself, the confines of the surgical site, etc.
- A highly viable alternative device is the hand-held electrosurgical instrument. As used herein, the term “electrosurgical instrument” includes a hand-held instrument capable of ablating tissue or cauterizing tissue, but does not include a catheter-based device. The instrument is relatively short (as compared to a catheter-based device), and rigidly couples the electrode tip to the instrument's handle that is otherwise held and manipulated by the surgeon. The rigid construction of the electrosurgical instrument requires direct, open access to the targeted tissue. Thus, for treatment of atrial fibrillation via an electrosurgical instrument, it is desirable to gain access to the patient's heart through one or more openings in the patient's chest (such as a sternotomy, a thoracotomy, a small incision and/or a port). In addition, the patient's heart may be opened through one or more incisions, thereby allowing access to the endocardial surface of the heart.
- Once the target site (e.g., right atrium, left atrium, epicardial surface, endocardial surface, etc.) is accessible, the surgeon positions the electrode tip of the electrosurgical instrument at the target site. The tip is then energized, ablating (or for some applications, cauterizing) the contacted tissue. A desired lesion pattern is then created (e.g., portions of a known “Maze” procedure) by moving the tip in a desired fashion along the target site. In this regard, the surgeon can easily control positioning and movement of the tip, as the electrosurgical instrument is rigidly constructed and relatively short (in contrast to a catheter-based ablation technique).
- Ablation of PV tissue may cause the PV to shrink or constrict due to the relatively small thickness of tissue formed within a PV. Because PV's have a relatively small diameter, a stenosis may result due to the ablation procedure. Even further, other vital bodily structures are directly adjacent each PV. These structures may be undesirably damaged when ablating within a PV. Therefore, a technique has been suggested whereby a continuous ablation lesion pattern is formed in the left atrium wall about the ostium associated with the PV in question. In other words, the PV is electrically isolated from the left atrium by forming an ablation lesion pattern that surrounds the PV ostium. As a result, any undesired electrical impulse generated within the PV would not propagate into the left atrium, thereby eliminating unexpected atria contraction.
- Electrosurgical instruments, especially those used for the treatment of atrial fibrillation, have evolved to include additional features that provide improved results for particular procedures. For example, U.S. Pat. No. 5,897,553, the teachings of which are incorporated herein by reference, describes a fluid-assisted electrosurgical instrument that delivers a conductive solution to the target site in conjunction with electrical energy, thereby creating a “virtual” electrode. The virtual electrode technique has proven highly effective in achieving desired ablation while minimizing collateral tissue damage. Other electrosurgical instrument advancements have likewise optimized system performance. However, a common characteristic associated with available electrosurgical instruments is a “designed-in” directional orientation. That is to say, electrosurgical devices, and especially those used for atrial fibrillation treatment procedures, are curved along a length thereof, as exemplified by the electrosurgical instrument of U.S. Pat. No. 5,897,553. In theory, this permanent curved feature facilitates the particular procedure (or lesion pattern) for which the electrosurgical instrument is intended. Unfortunately, however, the actual lesion pattern formation technique and/or bodily structure may vary from what is expected, so that the curve is less than optimal. Additionally, the pre-made curve may be well suited for one portion of a particular procedure (e.g., right atrium ablation pattern during the Maze procedure), but entirely inapplicable to another portion (e.g., left atrium ablation during the Maze procedure). As a result, the electrosurgical instrument design may actually impede convenient use by a surgeon.
- Electrosurgical instruments continue to be highly useful for performing a variety of surgical procedures, including surgical treatment of atrial fibrillation. While certain advancements have improved overall performance, the accepted practice of imparting a permanent curve or other shape variation into the instrument itself may impede optimal usage during a particular procedure. Therefore, a need exists for an electrosurgical instrument that, as initially presented to a surgeon, is indifferent to rotational orientation, and further is capable of independently maintaining a number of different shapes as desired by the surgeon.
- In cases of atrial fibrillation, it is desirable to identify the origination point of the undesired electrical impulses prior to ablation. Mapping may be accomplished by placing one or more mapping electrodes into contact with the tissue in question. Mapping of tissue may occur by placing one or more mapping electrodes into contact with the endocardial surface of the heart and/or the epicardial surface of the heart. Therefore, a need exists for a mapping instrument that is capable of mapping the heart, e.g., during an ablation procedure. Preferably, this mapping instrument, as initially presented to a surgeon, would be indifferent to rotational orientation, and further would be capable of independently maintaining a number of different shapes as desired by the surgeon.
- As used herein, the term “mapping instrument” includes a hand-held instrument capable of pacing and/or mapping cardiac tissue. The mapping instrument is similar to the electrosurgical instrument described above in that it is relatively short (as compared to a catheter-based device), and rigidly couples an electrode tip to the instrument's handle that is otherwise held and manipulated by the surgeon. The rigid construction of the mapping instrument requires direct, open access to the targeted tissue. Thus, for mapping and/or pacing of cardiac tissue via the mapping instrument, it is desirable to gain access to the patient's heart through one or more openings in the patient's chest (such as a sternotomy, a thoracotomy, a small incision and/or a port). In addition, the patient's heart may be opened through one or more incisions, thereby allowing access to the endocardial surface of the heart.
- Once the target site (e.g., right atrium, left atrium, right ventricle, left ventricle, epicardial surface, endocardial surface, pulmonary veins, etc.) is accessible, the surgeon positions the electrode tip of the mapping instrument at the target site. The surgeon can easily control positioning and movement of the tip, as the mapping instrument is rigidly constructed and relatively short (in contrast to a catheter-based technique).
- In cardiac resynchronization therapy (CRT) for the treatment of patients with congestive heart failure and ventricular dysynchrony, the heart is paced from both ventricles simultaneously by placing two ventricular leads on opposite sides of the heart. Various studies have shown that lead location can affect cardiac function; therefore, optimizing placement of the left ventricular lead on the left ventricular free wall may improve CRT results and patient outcomes.
- Venous anatomy may not allow a transvenous lead to be placed in an optimal location. However, an epicardial lead may be placed at any site on the heart, creating the opportunity to optimize lead position. There are several situations during implantation of a left ventricular lead in which one should consider converting from a transvenous lead procedure to an epicardial lead procedure. These include inability to cannulate the coronary sinus or the desired coronary vein, inability of the lead to properly lodge in the vein or lack of any vein in the preferred location.
- Interest in optimizing left ventricular lead placement for cardiac resynchronization therapy is being supported by growing data that demonstrate the location of the lead on the heart can affect hemodynamics and improve patient outcomes. Epicardial mapping is a technique to determine a patient-specific location for the left-sided pacing lead in CRT procedures.
- One aspect of the present invention relates to a system for ablating cardiac tissue comprising an electrosurgical instrument and a mapping instrument. The electrosurgical instrument includes an elongated shaft and a non-conductive handle. The shaft defines a proximal section, a distal section, and an internal lumen extending from the proximal section. The distal section forms an electrically conductive rounded tip and defines at least one passage fluidly connected to the lumen. This passage distributes fluid from the internal lumen outwardly from the shaft. Further, the shaft is adapted to be transitionable from a straight state to a bent state, preferably a number of different bent states. In this regard, the shaft is capable of independently maintaining the distinct shapes associated with the straight state and the bent state(s). The non-conductive handle is rigidly coupled to the proximal section of the shaft. With this in mind, an exterior surface of the shaft distal the handle and proximal the distal section is electrically non-conductive. In one preferred embodiment, the shaft is comprised of an elongated electrode body and an electrical insulator. The electrode body defines the distal section and is rigidly coupled to the handle. The electrical insulator surrounds at least a portion of the electrode body proximal the distal section such that the tip is exposed.
- During use, and when first presented to a surgeon, the shaft is in the straight state such that the electrosurgical instrument is effectively indifferent to a rotational orientation when the handle is grasped by the surgeon. Subsequently, the surgeon can bend the shaft to a desired shape (i.e., the bent state) being most useful for the particular electrosurgical procedure. During the procedure, a conductive fluid is directed onto the target site from the internal lumen via the passage. The tip then energizes the dispensed fluid, causing tissue ablation or cauterization.
- The mapping instrument also includes an elongated shaft and a non-conductive handle. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive rounded tip. Like the electrosurgical instrument, the shaft of the mapping instrument is adapted to be transitionable from a straight state to a bent state, preferably a number of different bent states. In this regard, the shaft is capable of independently maintaining the distinct shapes associated with the straight state and the bent state(s). The non-conductive handle is rigidly coupled to the proximal section of the shaft. With this in mind, an exterior surface of the shaft distal the handle and proximal the distal section is electrically non-conductive. In one preferred embodiment, the shaft is comprised of an elongated electrode body and an electrical insulator. The electrode body defines the distal section and is rigidly coupled to the handle. The electrical insulator surrounds at least a portion of the electrode body proximal the distal section such that the tip is exposed.
- During use, and when first presented to a surgeon, the shaft is in the straight state such that the mapping instrument is effectively indifferent to a rotational orientation when the handle is grasped by the surgeon. Subsequently, the surgeon can bend the shaft to a desired shape (i.e., the bent state) being most useful for the particular medical procedure.
- Yet another aspect of the present invention relates to an ablation system including an electrosurgical instrument, a source of conductive fluid, an energy source and a mapping instrument. The electrosurgical instrument includes an elongated shaft and a non-conductive handle. The shaft defines a proximal section, a distal section, and an internal lumen extending from the proximal section. The distal section forms an electrically conductive rounded tip and defines at least one passage fluidly connected to the lumen. Further, the shaft is adapted to be transitionable from, and independently maintain a shape in, a straight state and a bent state. The handle is rigidly coupled to the proximal section of the shaft. An exterior surface of the shaft distal the handle and proximal the distal section is electrically non-conductive. The source of conductive fluid is fluidly connected to the internal lumen. Finally, the energy source is electrically connected to the tip. During use, the electrosurgical instrument can be presented to the target site in either the straight state or the bent state. Regardless, the shaft independently maintains the shape associated with the selected state. Conductive fluid is delivered from the conductive fluid source to the internal lumen, and is then distributed to the target site via the passage. The energy source is activated, thereby energizing the electrode tip. This action, in turn, energizes the distributed conductive fluid, causing desired tissue ablation or cauterization. In one preferred embodiment, the electrosurgical system further includes an indifferent, or non-ablating, electrode (such as a grounding patch). The indifferent electrode is electrically connected to the energy source and it is placed separately from the target site. For example, the indifferent electrode may be placed on the back of the patient. The mapping instrument also includes an elongated shaft and a non-conductive handle. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive rounded tip. Further, the shaft is adapted to be transitionable from, and independently maintain a shape in, a straight state and a bent state. The handle is rigidly coupled to the proximal section of the shaft. An exterior surface of the shaft distal the handle and proximal the distal section is electrically non-conductive. Finally, the energy source is electrically connected to the tip. During use, the mapping instrument can be presented to the target site in either the straight state or the bent state. Regardless, the shaft independently maintains the shape associated with the selected state. The energy source is activated, thereby energizing the electrode tip. This action, in turn, causes desired tissue to be stimulated. In one preferred embodiment, the electrosurgical system further includes an indifferent, or non-ablating, electrode (such as a needle electrode). The indifferent electrode is electrically connected to the energy source and it is placed separately from the target site.
- Yet another aspect of the present invention relates to a method of performing an electrosurgical procedure. The method includes providing an electrosurgical instrument and a mapping instrument both including an elongated shaft and, a handle. In this regard, the shaft of the electrosurgical instrument defines a proximal section, a distal section, and an internal lumen. The proximal section is rigidly coupled to the handle, whereas the distal section forms a round tip. Finally, the internal lumen extends from the proximal section and is in fluid communication with at least one passage formed in the distal section. An exterior surface of the shaft distal the handle and proximal the distal section is electrically non-conductive. The shaft is provided in an initial straight state that otherwise defines a linear axis. The shaft is then bent to a first bent state in which a portion of the shaft is deflected relative to the linear axis. In this regard, the shaft independently maintains a shape of the first bent state. The shaft of the mapping instrument defines a proximal section and a distal section. The proximal section is rigidly coupled to the handle, whereas the distal section forms a round tip. An exterior surface of the shaft distal the handle and proximal the distal section is electrically non-conductive. The shaft is provided in an initial straight state that otherwise defines a linear axis. The shaft is then bent to a first bent state in which a portion of the shaft is deflected relative to the linear axis. In this regard, the shaft independently maintains a shape of the first bent state. The tip of the electrosurgical instrument is positioned at a tissue target site. In one preferred embodiment, an indifferent electrode is placed in contact with the patient. Conductive fluid is dispensed from the passage to the tissue target site via the internal lumen. Finally, energy is applied to the dispensed fluid by energizing the tip. Subsequently, the energized tip and conductive fluid ablates or cauterizes tissue at the tissue target site. In one embodiment, the tissue target site comprises tissue of a patient's heart, and the method further includes accessing the tissue target site through one or more openings in the patient's chest. In another embodiment, after a first lesion pattern is formed at a first tissue target site, the shaft is bent to a second shape and the procedure repeated to effectuate a second lesion pattern at a second tissue target site. In one embodiment, the tip of the mapping is positioned at a tissue target site comprising tissue of a patient's heart, and the method further includes accessing the tissue target site through one or more openings in the patient's chest.
- Yet another aspect of the present invention relates to a method of performing an electrosurgical procedure. The method comprises providing an instrument having an elongated shaft and a handle, the shaft defining a proximal section rigidly coupled to the handle, a distal section forming an electrically conductive tip; positioning the tip through a patient's chest; applying ablation energy to the tip while contacting cardiac tissue; creating an ablation lesion to isolate an area of cardiac tissue; stopping the application of ablation energy to the tip; repositioning the tip; and applying stimulation energy to the tip while contacting the area of isolated cardiac tissue to assess transmurality of the ablation lesion. The method further comprises an internal lumen extending from the proximal section of the shaft and in fluid communication with at least one passage formed in the distal section of the shaft. Conductive fluid is dispensed from the internal lumen of the shaft via the at least one passage while applying ablation energy to the tip. In one embodiment, the ablation energy is radiofrequency energy.
- Yet another aspect of the present invention relates to a method of performing a left sided epicardial lead placement procedure. The method comprises providing an instrument including an elongated shaft and a handle, the shaft defining a proximal section rigidly coupled to the handle, a distal section forming an electrically conductive tip; positioning the tip through a patient's chest to contact a first area of epicardial tissue of the patient's left ventricle; applying stimulation energy to the patient's right ventricle; recording the time at which a depolarization wave is sensed over the left ventricle following stimulation of the right ventricle; repositioning the tip to contact a second area of epicardial tissue of the patient's left ventricle; reapplying stimulation energy to the patient's right ventricle; recording the time at which the depolarization wave is sensed over the left ventricle following restimulation of the right ventricle; placing an epicardial lead in contact with the area of tissue that had the longest time interval at which the depolarization wave was sensed over the left ventricle following stimulation of the right ventricle. Once the optimal lead location site has been determined, it can visually marked by using adjacent anatomical landmarks. The mapping instrument is removed and an epicardial pacing lead implanted at that site.
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FIG. 1 is a side view of an electrosurgical system in accordance with the present invention, including portions shown in block form; -
FIG. 2 is a perspective view of an electrosurgical instrument portion of the system ofFIG. 1 , with a handle removed; -
FIG. 3 is an enlarged, cross-sectional view of a portion of an electrosurgical instrument ofFIG. 1 taken along the line 3-3; -
FIG. 4A is an enlarged, perspective view of a distal portion of the electrosurgical instrument ofFIG. 1 ; -
FIG. 4B is an enlarged, perspective view of a distal portion of an alternative embodiment electrosurgical instrument in accordance with the present invention; -
FIGS. 5A-5C are side views of the electrosurgical instrument ofFIG. 1 , illustrating exemplary shapes available during use of the electrosurgical instrument; -
FIG. 6 is an enlarged, side view of a portion of an alternative embodiment electrosurgical instrument in accordance with the present invention; -
FIG. 7A is a cut-away illustration of a patient's heart depicting use of an electrosurgical instrument in accordance with the present invention during a surgical ablation procedure; -
FIG. 7B is an enlarged illustration of a portion ofFIG. 7A ; -
FIGS. 8A and 8B are side perspective views of an alternative electrosurgical instrument in accordance with the present invention; -
FIG. 9A is an enlarged, perspective view of a distal portion of an alternative embodiment electrosurgical instrument in accordance with the present invention; -
FIG. 9B is an enlarged, transverse, cross-sectional view of the electrosurgical instrument ofFIG. 9A ; -
FIG. 9C is an enlarged, longitudinal, cross-sectional view of the electrosurgical instrument ofFIG. 9A ; -
FIG. 10A is an enlarged, perspective view of a distal portion of an alternative embodiment electrosurgical instrument in accordance with the present invention; -
FIG. 10B is an enlarged, cross-sectional view of the electrosurgical instrument ofFIG. 10A ; -
FIG. 10C is an enlarged, perspective view of a distal portion of an alternative embodiment electrosurgical instrument in accordance with the present invention; -
FIG. 10D is an enlarged, cross-sectional view of a portion of the electrosurgical instrument ofFIG. 10C ; -
FIG. 11 is an enlarged, cross-sectional view of a portion of an alternative embodiment electrosurgical instrument in accordance with the present invention; -
FIG. 12 is a schematic view illustrating an ablation lesion produced in accordance with the present invention; -
FIG. 13 is a schematic view illustrating an ablation lesion produced in accordance with the present invention; -
FIG. 14 is a side view of a mapping system in accordance with the present invention, including portions shown in block form; -
FIGS. 15A-15C are side views of the mapping instrument ofFIG. 14 , illustrating exemplary shapes available during use of the mapping instrument; -
FIG. 16 is a perspective view of a mapping instrument portion of the system ofFIG. 14 , with a handle removed; -
FIG. 17 is an enlarged, cross-sectional view of a portion of a mapping instrument ofFIG. 14 taken along the line 17-17; -
FIG. 18 is an enlarged, side view of a portion of an alternative embodiment of a mapping instrument in accordance with the present invention; -
FIG. 19A is a cut-away illustration of a patient's heart depicting use of a mapping instrument in accordance with the present invention during a surgical ablation procedure; -
FIG. 19B is an enlarged illustration of a portion ofFIG. 19A ; -
FIGS. 20A and 20B are side perspective views of an alternative embodiment of a mapping instrument in accordance with the present invention; -
FIG. 21A is an enlarged, perspective view of a distal portion of an alternative embodiment of a mapping instrument in accordance with the present invention; -
FIG. 21B is an enlarged, transverse, cross-sectional view of the mapping instrument ofFIG. 21A ; -
FIG. 21C is an enlarged, longitudinal, cross-sectional view of the mapping instrument ofFIG. 21A ; -
FIG. 22 is a cut-away illustration of a patient's heart depicting activation patterns and cell-to-cell conduction from right ventricular pacing; -
FIG. 23 is an illustration of a patient's heart depicting epicardial mapping to optimize left ventricular lead placement; -
FIG. 24 is a schematic of PDI measurement in accordance with one embodiment of the present invention; and -
FIG. 25 is a schematic of PDI measurement in accordance with one embodiment of the present invention. - One preferred embodiment of an
electrosurgical system 10 in accordance with the present invention is shown inFIG. 1 . Thesystem 10 is comprised of anelectrosurgical instrument 12, afluid source 14, apower source 16, and anindifferent electrode 18. The various components are described in greater detail below. In general terms, however, thefluid source 14 is fluidly connected to theelectrosurgical instrument 12. Similarly, thepower source 16 is electrically connected to theelectrosurgical instrument 12 and to theindifferent electrode 18. During use, conductive fluid is delivered from thefluid source 14 to a distal portion of theelectrosurgical instrument 12. The distributed fluid is energized by theelectrosurgical instrument 12 via thepower source 16. The so-energized conductive fluid is capable of forming a virtual electrode, which is capable of ablating or cauterizing contacted tissue. - The
electrosurgical instrument 12 includes ahandle 20 and ashaft 22. As described in greater detail below, theshaft 22 is rigidly coupled to thehandle 20, and is transitionable from a straight state (as illustrated inFIG. 1 ) to a bent state (for example as shown inFIGS. 5B and 5C ). In this regard, theshaft 22 independently maintains the shape associated with the particular state (i.e., straight or bent). - The
handle 20 is preferably made of a sterilizable, rigid, and non-conductive material, such as a polymer or ceramic. Suitable polymers include rigid plastics, rubbers, acrylics, nylons, polystyrenes, polyvinylchlorides, polycarbonates, polyurethanes, polyethylenes, polypropylenes, polyamides, polyethers, polyesters, polyolefins, polyacrylates, polyisoprenes, fluoropolymers, combinations thereof or the like. Further, thehandle 20 is ergonomically designed to comfortably rest within a surgeon's hand (not shown). To this end, thehandle 20 may include a grip portion 24 that is circular in cross section. This configuration facilitates grasping of thehandle 20, and thus of theelectrosurgical instrument 12, at any position along the grip portion 24 regardless of an overall rotational orientation of theelectrosurgical instrument 12. That is to say, due to the circular, cross-sectional shape of the grip portion 24, theelectrosurgical instrument 12 can be rotated to any position relative to a central axis A, and still be conveniently grasped by the surgeon. In an even more preferred embodiment, the grip portion 24 defines a gradual, distally increasing diameter that provides an orientation feature to help a surgeon identify where along the length of theelectrosurgical instrument 12 he or she is grasping. For example, if the surgeon grasps theelectrosurgical instrument 12 out of his visual sight during a medical procedure, the surgeon may identify based on the grip portion's 24 diameter where along the instrument he has grasped. Finally, the grip portion 24 is preferably formed of a low durometer polymer. Suitable polymers include low durometer plastics, rubbers, silicones, acrylics, nylons, polystyrenes, polyvinylchlorides, polycarbonates, polyurethanes, polyethylenes, polypropylenes, polyamides, polyethers, polyesters, polyolefins, polyacrylates, polyisoprenes, fluoropolymers, combinations thereof or the like. The grip portion 24 alternatively may be a sponge-like or foam-like material, such as an open-cell material or a closed-cell material. - Regardless of exact configuration, the
handle 20 forms or encompasses one or more central lumens (not shown). The lumen(s) provides a pathway for a line ortubing 26 from thefluid source 14 to theshaft 22, as well as a pathway for a line orwiring 28 from thepower source 16 to theshaft 22. In this regard,FIG. 2 illustrates theelectrosurgical instrument 12 with thehandle 20 removed. Thetubing 26 from the fluid source 14 (FIG. 1 ) is shown as extending to, and being fluidly connected with, theshaft 22. Similarly, theline 28 from the power source 16 (FIG. 1 ) is shown as extending to, and being electrically connected with, theshaft 22. - Returning to
FIG. 1 , theshaft 22 is an elongated, relatively rigid component defining aproximal section 40 and adistal section 42. Thedistal section 42 terminates in an electricallyconductive tip 44. As described in greater detail below, thetip 44 is rounded, defining a uniform radius of curvature. With this configuration, thetip 44 is, similar to thehandle 20, indifferent to rotational orientation of theelectrosurgical device 12. That is to say, regardless of how a surgeon (not shown) grasps the handle 20 (i.e., the rotational position of thehandle 20 relative to the central axis A), a profile of thetip 44 in all directions (e.g., in front of the surgeon's thumb position, behind the surgeon's thumb position, etc.) is always the same so that thetip 44 is readily maneuvered along tissue (not shown) in any direction. To this end, the rounded shape facilitates sliding movement of thetip 44 along the tissue. - With additional reference to
FIG. 3 , theshaft 22 defines aninternal lumen 50 that is fluidly connected to thetubing 26. In this way, theinternal lumen 50 delivers fluid from thefluid source 14 to thedistal section 42. - With additional reference to
FIG. 4A , thedistal section 42 preferably forms a plurality ofpassages 52 that are fluidly connected to theinternal lumen 50. Thepassages 52 are formed at or proximal thetip 44 and preferably are uniformly located relative to a circumference of thedistal section 42. For example, in one preferred embodiment, twosets passages 52 are provided, in addition to acentral passage 54 c at thetip 44. Thepassages 52 associated with each of the twosets passages 52 are uniformly located on a hemispherical portion of thetip 44 as described below. Alternatively, other numbers and locations are acceptable. By preferably uniformly spacing thepassages 52, however, thedistal section 42 is further formed to be indifferent to rotational orientation of theelectrosurgical instrument 12. In other words, regardless of the rotational position of theelectrosurgical instrument 12 and/or the direction oftip 44 movement, thepassages 52 provide a relatively uniform disbursement of conductive fluid about thetip 44 via theinternal lumen 50. In an alternative embodiment, thetip 44 is made of a porous material, that allows fluid to pass from theinternal lumen 50 through thetip 44. - In another alternative embodiment, and as best shown in
FIG. 4B , at least some of the passages 52 (for example, the passage set 54 b) are located along a generallyhemispherical portion 56 of thetip 44. This one preferred design facilitates a more complete delivery of liquid to a target site (not shown) that is otherwise contacted by thetip 44. In general terms, during an electrosurgical procedure, it is important that a sufficient volume of irrigation fluid is continually provided to theelectrode tip 44/target site tissue interface to reduce the opportunity for tissue charring or desiccation. Previous electrosurgical designs positioned all of the passages 52 (except for thecentral passage 54 c) along acylindrical portion 58 of the tip 44 (as opposed to the generally hemispherical portion 56). With this prior design, where a particular surgical procedure required that thetip 44 be oriented such that thepassages 52 are “below” theelectrode tip 44/target site tissue interface, some or all of the irrigation liquid otherwise dispensed from the passages 52 (other than thecentral passage 54 c) might flow away from the electrode tip 44 (or back along the shaft 22). The one preferred passage configuration ofFIG. 4B overcomes this concern, as all of the irrigation liquid distributed from thepassages 54 b on the generallyhemispherical portion 56 will be delivered to theelectrode tip 44/target site tissue interface due to surface tension at the interface. - Regardless of passage location, a further preferred feature of the
shaft 22 is a malleable or shapeable characteristic. In particular, and with additional reference toFIGS. 5A-5C , theshaft 22 is configured to be transitionable from an initial straight state (FIG. 5A ) to a bent or curved state (FIGS. 5B and 5C ). In this regard, theelectrosurgical instrument 12, and in particular theshaft 22, is initially presented to a surgeon (not shown) in the straight state ofFIG. 5A , whereby theshaft 22 assumes a straight shape defining the central axis A. In the straight state, theshaft 22 is indifferent to rotational orientation, such that theelectrosurgical instrument 12 can be grasped at any rotational position and thetip 44 will be located at an identical position. Further, as previously described, a profile of thetip 44 is also uniform or identical at any rotational position of theelectrosurgical instrument 12. Subsequently, depending upon the constraints of a particular electrosurgical procedure, theshaft 22 can be bent relative to the central axis A. Two examples of an applicable bent state or shape are provided inFIGS. 5B and 5C . In a preferred embodiment, theshaft 22 can be bent at any point along a length thereof, and can be formed to include multiple bends or curves. Regardless, theshaft 22 is configured to independently maintain the shape associated with the selected bent shape. That is to say, theshaft 22 does not require additional components (e.g., pull wires, etc.) to maintain the selected bent shape. Further, theshaft 22 is constructed such that a user can readily re-shape theshaft 22 back to the straight state ofFIG. 5A and/or other desired bent configurations. Notably, theshaft 22 is configured to relatively rigidly maintain the selected shape such that when a sliding force is imparted onto theshaft 22 as thetip 44 dragged across tissue, theshaft 22 will not overtly deflect from the selected shape. - In one preferred embodiment, the above-described characteristics of the
shaft 22 are achieved by forming theshaft 22 to include anelongated electrode body 60 and an electrical insulator covering 62 as shown inFIGS. 1 and 3 . Theelectrode body 60 defines theproximal section 40 and thedistal section 42 of theshaft 22. To this end, theproximal section 40 of theelectrode body 60 is rigidly coupled to thehandle 20. Theinsulator 62 covers a substantial portion of theelectrode body 60, preferably leaving thedistal section 42 exposed. In particular, theinsulator 62 is positioned to encompass an entirety of theelectrode body 60 distal thehandle 20 and proximal the distal section 42 (and in particular, proximal thepassages 52 and the tip 44). - In one preferred embodiment, the
electrode body 60 is a tube formed of an electrically conductive, malleable material, preferably stainless steel, however other materials such as, for example, nitinol can be used. Thepassages 52 are preferably drilled, machined, laser cut, or otherwise formed through at least a portion of theelectrode body 60. The passages oropenings 52 may comprise circular holes, semi-circular holes, oval holes, rectangular slots, and/or other configurations for allowing fluid to pass. - The
insulator 62 is formed of one or more electrically non-conductive materials, and serves to electrically insulate the encompassed portion of theelectrode body 60. Multiple layers of electrically non-conductive materials can help prevent the likelihood of forming an electrical short along the length of theelectrode body 60 due to a mechanical failure of one of the non-conductive materials. In this regard, theinsulator 62 is preferably comprised of two materials having considerably different mechanical properties, e.g., a silicone and a fluoropolymer. In one preferred embodiment, a silicone tubing material is overlaid with a heat shrink fluoropolymer tubing material. Alternatively, theinsulator 62 may be one or more non-conductive coatings applied over a portion of theelectrode body 60. In addition to being non-conductive, theinsulator 62 is preferably flexible and conforms to theelectrode body 60 such that theinsulator 62 does not impede desired shaping and re-shaping of theelectrode body 60 as previously described. - It will be understood that the preferred construction of the
shaft 22 to include theelongated electrode body 60 and theinsulator 62 is but one available configuration. Alternatively, theshaft 22 can be constructed of an electrode material forming thetip 44, and a rigid or malleable, non-conductive tube rigidly connecting thetip 44 to thehandle 20. The non-conductive tube can include one or more metal conductors, such as straight wire and/or windings for electrically connecting thetip 44 to thepower source 16. Along these same lines, another alternative embodiment includes forming thetip 44 from an inherently porous material. For example, thetip 44 may comprise one or more porous polymers, metals, or ceramics. Further, thetip 44 may be coated with non-stick coatings such as PTFE or other types of coatings such as biological coatings. Another alternative embodiment includes construction of theshaft 22 to include one or more metal conductors, such as straight wire and/or windings inside a rigid or malleable non-conductive polymer tube. The non-conductive polymer tube includes one or more openings, such as holes, slots or pores (preferably corresponding with thepassages 52 previously described), which allow conductive fluid to exit the polymer tube. The conductive fluid creates a virtual electrode via electrically connecting the one or more metal conductors to the target tissue. Conversely, theshaft 22 may comprise a polymer tube having one or more openings, such as holes, slots or pores (preferably corresponding with thepassages 52 previously described), placed inside an electrical conductor, such as a metal tube having one or more openings, such as holes, slots or pores, or a metal winding having a spacing that allows conductive fluid to pass through, to control conductive fluid delivery through the electrical conductor. Finally, theinsulator 62 may cover a portion of the metal tube or windings. - With respect to the above-described alternative embodiments, connection between the elongated tube and the
separate tip 44 can be accomplished in a variety of manners. Once again, the elongated tube can comprise a conductive or non-conductive material(s), such as metal(s) or plastic(s). The elongated tube can be connected to thetip 44 via a variety of coupling techniques, including, for example, welding, laser welding, spin welding, crimping, gluing, soldering and press fitting. Alternatively, the distal end of the elongated tube and thetip 44 can be configured to threadably engage one another and/or mechanical engagement member(s) (e.g., pins, screws, rivets, etc.) can be employed. In another embodiment, the elongated tube is rigidly coupled to thetip 44. In yet another embodiment, thetip 44 can be moveably coupled to the elongated tube, whereby thetip 44 can be moved and/or locked relative to the elongated tube. For example, thetip 44 can be coupled to the elongated tube via one or more joints or hinges. The joints or hinges can be ball joints and/or joints that include a pin. To this end, a pin-type joint can be configured to allow thetip 44 to swivel relative to the elongated tube. Further, the joint(s) can be configured to move and lock into position. In addition, one or more actuators (e.g., knobs, buttons, levers, slides, etc.) can be located on, for example, the handle 20 (FIG. 1 ) for actuating the joint(s). With the above in mind,FIG. 6 illustrates a portion of analternative embodiment shaft 22′ including atip 44′ moveably coupled to anelongated tube 63 by apin 64. - Returning to
FIG. 1 , theelectrosurgical instrument 12 preferably includes acoupling member 65 for rigidly coupling theshaft 22 to thehandle 20. Thecoupling member 65 can comprise one or more polymers, plastics, and/or rubbers. For example, thecoupling member 65 can comprise one or more silicones, acrylics, nylons, polystyrenes, polyvinylchlorides, polycarbonates, polyurethanes, polyethylenes, polypropylenes, polyamides, polyethers, polyesters, polyolefins, polyacrylates, polyisoprenes, fluoropolymers, combinations thereof or the like. Thecoupling member 65 preferably forms adrip edge 66 to interrupt, divert and prevent any flow of liquid from thetip 44, down theshaft 22 and onto thehandle 20, thereby preventing any electrically conducting fluid from contacting the surgeon. - Regardless of exact construction of the
electrosurgical instrument 12, thefluid source 14 maintains a supply of conductive fluid (not shown), such as an energy-conducting fluid, an ionic fluid, a saline solution, a saturated saline solution, a Ringer's solution, etc. It is preferred that the conductive fluid be sterile. The conductive fluid can further comprise one or more contrast agents, and/or biological agents such as diagnostic agents, therapeutic agents or drugs. The biological agents may be found in nature (naturally occurring) or may be chemically synthesized. - As a point of reference, during use the conductive fluid serves to electrically couples the
electrode tip 44 ofelectrosurgical instrument 12 to the tissue to be treated, thereby lowering the impedance at the target site. The conductive fluid may create a larger effective electrode surface. The conductive fluid can help cool thetip 44 of theelectrosurgical instrument 12. The conductive fluid may keep the surface temperature of thetip 44 below the threshold for blood coagulation, which may clog theelectrosurgical instrument 12. The conductive fluid may also cool the surface of the tissue thereby preventing over heating of the tissue which can cause popping, desiccation, burning and/or charring of the tissue. The burning and/or charring of the tissue may also clog theelectrosurgical instrument 12. Therefore, use of the conductive fluid may reduce the need to remove a clogged electrosurgical instrument for cleaning or replacement. Further, charred tissue has high impedance, thereby making the transfer of RF energy difficult, and may limit the ability of theelectrosurgical instrument 12 to form a transmural lesion. The delivery of conductive fluid during the electrosurgical process may help create deeper lesions that are more likely to be transmural. Transmurality is achieved when the full thickness of the target tissue is ablated. Continuous conductive fluid flow may ensure that a conductive fluid layer between thetip 44 and the contours of the tissue to be treated is created. - In one preferred embodiment, the
fluid source 14 includes a fluid reservoir, such as a bag, a bottle or a canister, for maintaining a supply of conductive fluid previously described. With this configuration, the fluid reservoir can be positioned at an elevated location, thereby gravity feeding the conductive fluid to theelectrosurgical instrument 12, or the fluid reservoir may be pressurized, thereby pressure feeding the conductive fluid to theelectrosurgical instrument 12. For example, a pressure cuff may be placed around a flexible bag, such as an IV bag, of conductive fluid, thereby pressure feeding the conductive fluid to theelectrosurgical instrument 12. Alternatively, thefluid source 14 can include, and/or be connected to, a manual or electrical pump (not shown), such as an infusion pump, a syringe pump, or a roller pump. Thefluid source 14 can further comprise one or more orifices or fluid regulators, (e.g., valves, fluid reservoirs, conduits, lines, tubes and/or hoses) to control flow rates. The conduits, lines, tubes, or hoses may be flexible or rigid. For example, a flexible hose may be used to communicate fluid from thefluid source 14 to theelectrosurgical instrument 12, thereby allowingelectrosurgical instrument 12 to be easily manipulated by a surgeon. Alternatively, thefluid source 14 can be directly connected to, or incorporated into, thehandle 20. For example, a pressurized canister of conductive fluid may be directly connected to thehandle 20. Further, thefluid source 14 can comprise a syringe, a squeeze bulb and/or some other fluid moving means, device or system. - In another embodiment, the
fluid source 14 further includes a surgeon-controlled switch (not shown). For example, a switch may be incorporated in or on thefluid source 14 or any other location easily and quickly accessed by a surgeon for regulation of conductive fluid delivery. The switch may be, for example, a hand switch, a foot switch, or a voice-activated switch comprising voice-recognition technologies. - In yet another alternative embodiment, the
fluid source 14 includes a visual and/or audible signaling device (not shown) used to alert a surgeon to any change in the delivery of conductive fluid. For example, a beeping tone or flashing light can be used to alert the surgeon that a change has occurred in the delivery of conductive fluid. - The
power source 16 is of a type known in the art, and is preferably a radio-frequency (RF) generator. The generator can be powered by AC current, DC current or it can be battery powered either by a disposable or re-chargeable battery. The generator can incorporate a controller (not shown) or any suitable processor to control power levels delivered to theelectrosurgical instrument 12 based on information supplied to the generator/controller. - The above-described
electrosurgical system 10, including theelectrosurgical instrument 12, is useful for a number of different tissue ablation and cauterization procedures. For example, theelectrosurgical system 10 can be used to remove hemorrhoids or varicose veins or stop esophageal bleeding to name but a few possible uses. Additionally, theelectrosurgical system 10 is highly useful for the surgical treatment of cardiac arrhythmia, and in particular treatment of atrial fibrillation via ablation of atrial tissue. To this end, the Maze procedure, such as described in Cardiovascular Device Update, Vol. 1, No. 4, July 1995, pp. 2-3, the teachings of which are incorporated herein by reference, is a well known technique, whereby lesion patterns are created along specified areas of the atria. The Maze III procedure, a modified version of the original Maze procedure, has been described in Cardiac Surgery Operative Technique, Mosby Inc., 1997, pp. 410-419, the teachings of which are incorporated herein by reference. In an effort to reduce the complexity of the surgical Maze procedure, a modified Maze procedure was developed as described in The Surgical Treatment of A trial Fibrillation, Medtronic Inc., 2001, the teachings of which are incorporated herein by reference. -
FIG. 7A depicts use of theelectrosurgical system 10, and in particular theelectrosurgical instrument 12, performing a portion of the Maze procedure. In particular,FIG. 7A includes a representation of aheart 70 with itsleft atrium 72 exposed. Prior to use, theelectrosurgical instrument 12 is provided to the surgeon (not shown) with theshaft 22 in the initial straight state (FIG. 1 ). The surgeon then evaluates the constraints presented by thetissue target site 74 and the desired lesion pattern to be formed. Following this evaluation, the surgeon determines an optimal shape of theshaft 22 most conducive to achieving the desired ablation/lesion pattern. With this evaluation in mind, the surgeon then transitions or bends theshaft 22 from the initial straight state to the bent state illustrated inFIG. 7A . Once again, theshaft 22 is configured to independently maintain this selected shape. Theshaft 22 can be bent by hand and/or by use of bending jigs or tools. - Once the desired shape of the
shaft 22 has been achieved, thetip 44 is directed to thetissue target site 74. An indifferent electrode (18 inFIG. 1 , but not shown inFIG. 7A ) is placed in contact with the patient. Conductive fluid from the fluid source 14 (FIG. 1 ) is delivered to thetissue target site 74 via the internal lumen 50 (FIG. 3 ), thepassages 52 and/or theporous tip 44. Once sufficient fluid flow has been established, thetip 44 is energized via the power source 16 (FIG. 1 ). Thetip 44, in turn, energizes the distributed fluid, thereby creating a virtual electrode that ablates contacted tissue. The surgeon then slides or drags thetip 44 along theleft atrium 70 tissue, thereby creating a desiredlesion pattern 78, as best shown inFIG. 7B . In this regard, the rigid coupling between theshaft 22 and thehandle 20 allows thetip 44 to easily be slid along the atrial tissue via movement of thehandle 20. Once the desiredlesion pattern 78 has been completed, energization of thetip 44 is discontinued, as well as delivery of conductive fluid from thefluid source 14. If additional lesion patterns are required, the surgeon again evaluates the target tissue site, and re-forms theshaft 22 accordingly. - Notably, the
shaft 22 need not necessarily be bent to perform a tissue ablation procedure. Instead, thetip 44 can be drug across thetarget site tissue 74 with theshaft 22 in the initial straight state. In this regard, because theshaft 22 is straight and the handle 20 (FIG. 1 ) is preferably circumferentially uniform, theelectrosurgical instrument 12 does not have a discernable drag direction (as compared to theshaft 22 being bent or curved, whereby the curve inherently defines a most appropriate drag direction). - In addition to the exemplary procedure described above, the
electrosurgical instrument 12 may be positioned and used, for example, through a thoracotomy, through a sternotomy, percutaneously, transveneously, arthroscopically, endoscopically, for example, through a percutaneous port, through a stab wound or puncture, through a small incision, for example, in the chest, in the groin, in the abdomen, in the neck or in the knee, or in combinations thereof. It is also contemplated that theelectrosurgical instrument 12 may be used in other ways, for example, in open-chest surgery on a heart in which the sternum is split and the rib cage opened with a retractor. - The
electrosurgical system 10, and in particular theelectrosurgical instrument 12, described above with respect toFIG. 1 is but one acceptable configuration in accordance with the present invention. That is to say, thesystem 10 and/or theinstrument 12 can assume other forms and/or include additional features while still providing an electrosurgical instrument having a shaft that independently maintains varying shapes associated with a straight state and a bent state, and is indifferent to rotational orientation in the straight state. - For example, the
electrosurgical instrument 12 can include a surgeon-controlled switch. For example, a switch may be incorporated in or on theelectrosurgical instrument 12 or any other location easily and quickly accessed by the surgeon for regulation of theelectrosurgical instrument 12 by the surgeon. The switch may be, for example, a hand switch, a foot switch, or a voice-activated switch comprising voice-recognition technologies. One or more switches may be incorporated into the grip portion 24 of theelectrosurgical instrument 12. For example, a switch may be used to control conductive fluid delivery and/or power delivery. A switch incorporated into the grip portion 24 may be a switch, such as a membrane switch, encompassing the entire circumference of theelectrosurgical instrument 12, thereby effectively being indifferent to a rotational orientation when the surgeon grasps the handle. That is to say, due to the cross-sectional shape of the switch, theelectrosurgical instrument 12 may be rotated to any position relative to a central axis A, and still be conveniently controlled by the surgeon. - Alternatively, a hand switch connected to the
electrosurgical instrument 12, but not incorporated into theelectrosurgical instrument 12, may be used. For example, a switch designed to be worn by a surgeon, for example on a surgeon's thumb, may be used to activate and/or deactivate theelectrosurgical instrument 12. A switch may be incorporated into a cuff or strap that is placed on or around the thumb or finger of a surgeon. Alternatively, a switch may be designed to fit comfortably in a surgeon's palm. - One or more visual and/or audible signals used to alert a surgeon to the completion or resumption of ablation, conductive fluid delivery and/or power delivery, for example, may be incorporated into the
electrosurgical instrument 12. For example, a beeping tone or flashing light that increases in frequency as the ablation period ends or begins may be used. Alternatively or in addition, an indicator light otherwise located on the electrosurgical instrument can be inductively coupled to thepower source 16 and adapted such that when power is being delivered to theelectrosurgical instrument 12, the light is visible to the surgeon or other users. - An alternative embodiment
electrosurgical instrument 112 is provided inFIGS. 8A and 8D . Theelectrosurgical instrument 112 is highly similar to the electrosurgical instrument 12 (FIG. 1 ) previously described, and includes ahandle 120, ashaft 122, afluid supply tube 126 andwiring 128. Theshaft 122 is virtually identical to the shaft 22 (FIG. 1 ) previously described, and forms atip 124 having passages (not shown) fluidly connected to an internal lumen (not shown). Further, theshaft 122 is adapted to be bendable from a straight state (FIG. 8A ) to multiple bent states (one of which is illustrated inFIG. 8B ), with theshaft 122 independently maintaining a shape associated with the particular state. Similar to previous embodiments, thefluid supply tube 126 fluidly connects the fluid source 14 (FIG. 1 ) to theshaft 122, whereas thewiring 128 electrically connects the power source 16 (FIG. 1 ) to theshaft 122. - The
handle 120 varies from the handle 20 (FIG. 1 ) previously described in that thehandle 120 does not define a curved outer surface. Instead, thehandle 120 is hexagonal in transverse cross-section. This alternative configuration is, however, indifferent to rotational orientation when grasped by a user, thereby promoting the preferred ease of use feature previously described. Notably, thehandle 120 can alternatively be formed to a variety of other symmetrical transverse cross-sectional shapes (e.g., circular, octagonal, etc.). - In yet another alternative embodiment, the electrosurgical system 10 (
FIG. 1 ) further includes a controller (not shown) that can also gather and process information from theelectrosurgical instrument fluid source 14 and/or one or more sensors or sensing elements such as temperature sensors or probes. The information supplied to or gathered by the controller can be used to adjust, for example, conductive fluid delivery, power levels, and/or energization times. For example, a temperature sensor coupled to the controller can be located in the distal section 42 (FIG. 1 ) of theelectrosurgical instrument 12. The temperature sensor can be a thermocouple element that measures the temperature of thetip 44 rather than the temperature of the conductive fluid or the temperature of the tissue being ablated. Alternatively, the temperature sensor can be a thermocouple element that measures the temperature of the conductive fluid or a thermocouple element that measures the temperature of the tissue being ablated. When the ablation site is being irrigated with a conductive fluid, the temperature of the tissue may differ to some degree from the temperature of the conductive fluid or the temperature of thetip 44. - Heat, 1.0 kcal/g, is required to raise the temperature of water, present at the ablation site, by 1° C. However, due to the unique chemical structure of the water molecule, additional heat is required for water to change phase from the liquid phase to the gaseous phase. If the temperature at the ablation site exceeds 100° C., water will change phase, boil and may result in an audible “steam pop” within the tissue. This pop may damage and even rupture the tissue. Therefore, it is desirable to prevent the ablation site from getting to hot. In addition, to form a permanent ablation lesion the temperature of the tissue at the ablation site must be elevated to approximately 50° C. or greater. For these reasons, it is desirable to use one or more temperature-sensing elements such as, for example, thermocouples, thermisters, temperature-sensing liquid crystals, temperature-sensing chemicals, thermal cameras, and/or infrared (IR) fiber optics, to monitor the temperature of the ablation site during the ablation procedure.
- With the above in mind,
FIGS. 9A-9C depict a portion of an alternative embodimentelectrosurgical device 140, and in particular adistal section 142 thereof. Theelectrosurgical instrument 140 is highly similar to previous embodiments, and includes ashaft 144 terminating at an electricallyconductive tip 146 havingpassages 148 formed therein that are fluidly connected to aninternal lumen 150. Further, theelectrosurgical instrument 140 includes atemperature probe 160 for monitoring tissue temperature of the tissue being ablated. Thetemperature probe 160 is placed at thetip 146. A ring ofinsulation material 162 may be used to electrically and thermally isolate thetemperature probe 160 from the electricallyconductive tip 146. The preferred central placement of thetemperature probe 160 at thetip 146 allows thetemperature probe 160 to directly contact a tissue surface in a number of orientations. The preferred insulatingmaterial 162 helps to prevent the thermal mass of thetip 146 and the RF energy from interfering with temperature information otherwise provided by theprobe 160. - An alternative embodiment for monitoring temperature includes an IR optical fiber system. As shown in
FIGS. 10A-10D , an alternative embodimentelectrosurgical instrument 190 may include anoptical fiber 192 for monitoring temperature based on IR. Theoptical fiber 192 can be positioned adjacent a tip 194 otherwise defined by the instrument 190 (FIGS. 10A and 10B ) or within the tip 194 itself (FIGS. 10C and 10D ). - The above-described temperature-sensing
elements - Along these same lines, the above-mentioned controller can incorporate one or more switches to facilitate regulation of the various components of the electrosurgical system 10 (
FIG. 1 ) by the surgeon. One example of such a switch is a foot pedal. The switch can also be, for example, a hand switch as described above, or a voice-activated switch comprising voice-recognition technologies. The switch can be incorporated in or on one of the surgeon's instruments, such as surgical site retractor, e.g., a sternal or rib retractor, or the electrosurgical instrument 12 (FIG. 1 ), or any other location easily and quickly accessed by the surgeon. The controller can also include a display or other means of indicating the status of various components to the surgeon, such as a numerical display, gauges, a monitor display or audio feedback. - Finally, a visual and/or audible signal used to alert a surgeon to the completion or resumption of ablation, sensing, monitoring, and/or delivery of conductive fluid can be incorporated into the controller. For example, a beeping tone or flashing light that increases in frequency as the ablation or electrocautery period ends or begins can be provided.
- In yet another alternative embodiment, the
fluid source 14 can be slaved to theelectrosurgical instrument 12, thepower source 16 and/or one or more sensors (as previously described). For example, thefluid source 14 can be designed to automatically stop or start the delivery of conductive fluid during the delivery of RF energy. Conversely, the delivery of RF energy may be slaved to the delivery of conductive fluid. That is the delivery of RF energy to thetip 44 would be coupled to the delivery of conductive fluid to thetip 44. If the flow of conductive fluid to thetip 44 were stopped, the RF energy delivered to thetip 44 would also automatically stop. For example, a switch responsive to the delivery of conductive fluid to thetip 44 for controlling RF energy delivery to thetip 44 can be incorporated into theelectrosurgical instrument 12. The switch can be located, for example, within theshaft 22 or thehandle 20 ofelectrosurgical instrument 12. - With the above in mind,
FIG. 11 illustrates a portion of an alternative embodimentelectrosurgical instrument 200 including ashaft 202 extending from a handle (not shown). Theshaft 202 includes an electricallyconductive tip 204 and a malleable,non-conductive tube 206 rigidly connecting thetip 204 to the handle. An electrically conductingswitch piston 208 is located within thenon-conductive tube 206. The conductingswitch piston 208 is electrically coupled to the power source 16 (FIG. 1 ). The conductingswitch piston 208 is movably held in a non-contacting position relative to thetip 204 by a spring or other elastic means (not shown). As conductive fluid is delivered, a pressure develops behind anorifice 210 of the conductingswitch piston 208. The size and shape of theorifice 210 is selected based on expected fluid delivery rates and pressures. When the necessary pressure or force to over come the spring retaining pressure or force is reached, the conductingswitch 208 travels distally towards thetip 204, thereby making an electrical contact with thetip 204. Other means can be used to slave the delivery of power to thetip 204 of theelectrosurgical instrument 200 to the delivery of conductive fluid to thetip 204 of theelectrosurgical instrument 200. For example, the controller can incorporate one or more switches to facilitate the regulation of RF energy based on the delivery of conductive fluid. - The incision patterns of a Maze III procedure are described in the book ‘Cardiac Surgery Operative Technique’ by Donald B. Doty, M.D. at pages 410-419, incorporated herein by reference in its entirety, and hereafter referred to as the “Doty Reference.” The left atrial isthmus lesion 558 (see
FIG. 12 ) extends from a pulmonaryvein isolation lesion 546, inferior of the pulmonary veins, crosses over the coronary sinus and ends at themitral valve annulus 560. Thelesion 558 corresponds to the incision illustrated as step S as described in the Doty reference. Thelesion 558 may be created via an epicardial or endocardial approach. The lesion may also be created via a coronary sinus approach comprising the advancement ofelectrode tip 44 ofelectrosurgical instrument 12 into thecoronary sinus 570. In particular,FIG. 12 is a schematic drawing illustrating the right and left atria, 500, 502, respectively, as viewed from a lower aspect, includingtricuspid valve 516, orifice ofcoronary sinus 570, andmitral valve 514 and as viewed from a more superior aspect, including the bases of thepulmonary veins 512 and the bases of the superior vena cava and inferior vena cava, 508, 510, respectively, which enter theright atrium 500. The right and left atrial appendages are also illustrated schematically at 505 and 550, respectively.FIG. 13 is a schematic drawing illustrating thelesion 558 crossing over thecoronary sinus 570 and thecircumflex artery 580 as viewed from a posterior view of theheart 70. - Prior to the ablation procedure, the surgeon evaluates the constraints presented for advancing
electrode tip 44 into thecoronary sinus 570 from within theright atrium 500. Following this evaluation, the surgeon determines an optimal shape of theshaft 22 most conducive to achieving the desired ablation lesion from within thecoronary sinus 570. With this evaluation in mind, the surgeon then transitions or bends theshaft 22 into a desired state. Once again, theshaft 22 is configured to independently maintain the selected shape. - Once the desired shape of the
shaft 22 has been achieved, thetip 44 is advanced into theright atrium 500 and into thecoronary sinus 570.Ablating tip 44 may be advanced into theright atrium 500 through an incision, i.e., an atriotomy (not shown). If the heart is beating, i.e., the heart is not on cardiopulmonary bypass, a purse-string suture may be used to minimize blood loss through the incision and around the device. Once inside theright atrium 500,tip 44 is advanced into thecoronary sinus 570 untiltip 44 reaches the desired location within the coronary sinus for creation of theablation lesion 558. Proper ablative tip placement can be confirmed by palpitation of the coronary sinus, for example, in an open-chest procedure. For procedures wherein the coronary sinus cannot be palpitated,electrosurgical instrument 12 may include one or more additional features. For example,electrosurgical instrument 12 may include a pressure monitoring sensor or port, thereby allowing one to monitor pressure during placement and use of the device. Pressures of the right atrium and the coronary sinus may be used to confirm proper placement of theablative tip 44 in the coronary sinus. Alternatively, an echo enhancing feature or material may be added toelectrosurgical instrument 12 thereby allowing the proper placement of thetip 44 into the coronary sinus to be confirmed via transesophageal echocardiography (TEE). Alternatively,electrosurgical instrument 12 may include one or more light sources forlighting tip 44. An endoscope could then be used to visually confirm proper placement oftip 44 in the coronary sinus since the light emanating from the tip would shine through the thin tissue wall of the coronary sinus. Oncetip 44 is advanced into the coronary sinus at the proper depth or distance, conductive fluid from the fluid source 14 (FIG. 1 ) is delivered to the ablation area via the internal lumen 50 (FIG. 3 ), thepassages 52 and/or theporous tip 44. Once sufficient fluid flow has been established,tip 44 is energized via the power source 16 (FIG. 1 ). Thetip 44, in turn, energizes the distributed fluid, thereby creating a virtual electrode that ablates contacted tissue within the coronary sinus. Once thelesion 558 has been completed, energization of thetip 44 is discontinued, as well as delivery of conductive fluid from thefluid source 14. If additional lesions are required, the surgeon again evaluates the target tissue site, and re-forms theshaft 22 accordingly. - It is contemplated that the
ablation lesion 558 may be created via placement of one or more ablative elements within the coronary sinus. In addition, it is contemplated that one or more ablative energies may be used with one or more ablative elements to createablation lesion 558, for example, radiofrequency energy, ultrasound energy, laser energy, microwave energy, and/or combinations thereof, may be used. Alternatively, one or more cryo ablation elements could be placed within the coronary sinus to formlesion 558. - In yet another embodiment, and with general reference to
FIG. 1 , theelectrosurgical instrument 12, thefluid source 14 and/or thepower source 16 can be slaved to a robotic system or a robotic system may be slaved to theelectrosurgical instrument 12, thefluid source 14 and/or thepower source 16. - The electrosurgical system, and in particular the electrosurgical instrument, of the present invention provides a marked improvement over previous designs. The handle and shaft are configured to be indifferent to rotational orientation when initially presented to a surgeon. Subsequently, the surgeon can conveniently shape or bend the shaft so as to provide a shape most conducive to forming the lesion pattern required by the particular surgical procedure. In this regard, the shaft independently maintains the selected shape throughout the particular electrosurgical procedure. Subsequently, the shaft can be re-shaped back to a straight configuration, or to any other desired curvature.
- One embodiment of a
mapping system 310 in accordance with the present invention is shown inFIG. 14 . Thesystem 310 is comprised of amapping instrument 312, adiagnostic device 316 and anindifferent electrode 318. The various components are described in greater detail below. In general terms, thediagnostic device 316 is electrically connected to themapping instrument 312 and to the indifferent orgrounding electrode 318. In one embodiment, thediagnostic device 316 may be the Medtronic Programmer/Analyzer model 2090/2290 which has the capability of pacing and sensing. - The
mapping instrument 312 includes ahandle 320 and ashaft 322. As described in greater detail below, theshaft 322 is rigidly coupled to thehandle 320, and is transitionable from a straight state (as illustrated inFIGS. 14 and 15 A) to a bent state (for example as shown inFIGS. 15B and 15C ). In this regard, theshaft 322 independently maintains the shape associated with the particular state (i.e., straight or bent). - The
handle 320 is preferably made of a sterilizable, rigid, and non-conductive material, such as a polymer or ceramic. Suitable polymers include rigid plastics, rubbers, acrylics, nylons, polystyrenes, polyvinylchlorides, polycarbonates, polyurethanes, polyethylenes, polypropylenes, polyamides, polyethers, polyesters, polyolefins, polyacrylates, polyisoprenes, fluoropolymers, combinations thereof or the like. Further, thehandle 20 is ergonomically designed to comfortably rest within a surgeon's hand (not shown). To this end, thehandle 320 may include agrip portion 324 that is circular in cross section. This configuration facilitates grasping of thehandle 320, and thus of themapping instrument 312, at any position along thegrip portion 324 regardless of an overall rotational orientation of themapping instrument 312. That is to say, due to the circular, cross-sectional shape of thegrip portion 324, themapping instrument 312 can be rotated to any position relative to a central axis A, and still be conveniently grasped by the surgeon. In one embodiment, thegrip portion 324 defines a gradual, distally increasing diameter that provides an orientation feature to help a surgeon identify where along the length of themapping instrument 312 he or she is grasping. For example, if the surgeon grasps themapping instrument 312 out of his visual sight during a medical procedure, the surgeon may identify based on the grip portion's 324 diameter where along the instrument he has grasped. Finally, thegrip portion 324 may be formed of a low durometer polymer. Suitable polymers include low durometer plastics, rubbers, silicones, acrylics, nylons, polystyrenes, polyvinylchlorides, polycarbonates, polyurethanes, polyethylenes, polypropylenes, polyamides, polyethers, polyesters, polyolefins, polyacrylates, polyisoprenes, fluoropolymers, combinations thereof or the like. Thegrip portion 324 alternatively may be a sponge-like or foam-like material, such as an open-cell material or a closed-cell material. - Regardless of exact configuration, the
handle 320 may form or encompass one or more central lumens (not shown). The lumen(s) can provide a pathway for a line or wiring 328 from thediagnostic device 316 to theshaft 322. In this regard,FIG. 16 illustrates themapping instrument 312 with thehandle 320 removed. Theline 328 from the diagnostic device 316 (FIG. 14 ) is shown as extending to, and being electrically connected with, theshaft 322. - Returning to
FIG. 14 , theshaft 322 is an elongated, relatively rigid component defining aproximal section 340 and adistal section 342. Thedistal section 342 terminates in an electricallyconductive tip 344. As described in greater detail below, thetip 344 may be rounded, defining a uniform radius of curvature. In one embodiment, thetip 344 may be shaped like a round ball. Thetip 344 may be textured. With the tip being in a rounded configuration, thetip 344 is, similar to thehandle 320, indifferent to rotational orientation of themapping device 312. That is to say, regardless of how a surgeon (not shown) grasps the handle 320 (i.e., the rotational position of thehandle 320 relative to the central axis A), a profile of thetip 344 in all directions (e.g., in front of the surgeon's thumb position, behind the surgeon's thumb position, etc.) is always the same so that thetip 344 is readily maneuvered along tissue (not shown) in any direction. To this end, the rounded shape can facilitate a sliding movement of thetip 344 along the tissue. - A preferred feature of the
shaft 322 is a malleable or shapeable characteristic. In particular, and with additional reference toFIGS. 15A-15C , theshaft 322 is configured to be transitionable from an initial straight state (FIG. 15A ) to a bent or curved state (FIGS. 15B and 15C ). In this regard, themapping instrument 312, and in particular theshaft 322, is initially presented to a surgeon (not shown) in the straight state ofFIG. 15A , whereby theshaft 322 assumes a straight shape defining the central axis A. In the straight state, theshaft 322 is indifferent to rotational orientation, such that themapping instrument 312 can be grasped at any rotational position and thetip 344 will be located at an identical position. Further, as previously described, a profile of thetip 344 is also uniform or identical at any rotational position of themapping instrument 312. Subsequently, depending upon the constraints of a particular mapping procedure, theshaft 322 can be bent relative to the central axis A. Two examples of an applicable bent state or shape are provided inFIGS. 15B and 15C . In a preferred embodiment, theshaft 322 can be bent at any point along a length thereof, and can be formed to include multiple bends or curves. Regardless, theshaft 322 is configured to independently maintain the shape associated with the selected bent shape. That is to say, theshaft 322 does not require additional components (e.g., pull wires, etc.) to maintain the selected bent shape. Further, theshaft 322 is constructed such that a user can readily re-shape theshaft 322 back to the straight state ofFIG. 15A and/or other desired bent configurations. Notably, theshaft 322 is configured to relatively rigidly maintain the selected shape such that when a force is imparted onto theshaft 322 as thetip 344 contacts tissue, theshaft 322 will not overtly deflect from the selected shape. - In one preferred embodiment, the above-described characteristics of the
shaft 322 are achieved by forming theshaft 322 to include anelongated electrode body 360 and an electrical insulator covering 362 as shown inFIGS. 14 and 17 . Theelectrode body 360 defines theproximal section 340 and thedistal section 342 of theshaft 322. To this end, theproximal section 340 of theelectrode body 360 is rigidly coupled to thehandle 320. Theinsulator 362 covers a substantial portion of theelectrode body 360, preferably leaving thedistal section 342 exposed. In particular, theinsulator 362 is positioned to encompass an entirety of theelectrode body 360 distal thehandle 320 and proximal the distal section 342 (and in particular, proximal the tip 344). - In one preferred embodiment, the
electrode body 360 is formed of an electrically conductive, malleable material, preferably stainless steel, however other materials such as, for example, nitinol can be used. Theinsulator 362 is formed of one or more electrically non-conductive materials, e.g., a nonconductive fluoropolymer, and serves to electrically insulate the encompassed portion of theelectrode body 360. Multiple layers of electrically non-conductive materials can help prevent the likelihood of forming an electrical short along the length of theelectrode body 360 due to a mechanical failure of one of the non-conductive materials. In this regard, theinsulator 362 is preferably comprised of two materials having considerably different mechanical properties, e.g., a silicone and a fluoropolymer. In one embodiment, a silicone tubing material is overlaid with a heat shrink fluoropolymer tubing material. Alternatively, theinsulator 362 may be one or more non-conductive coatings applied over a portion of theelectrode body 360. In addition to being non-conductive, theinsulator 362 is preferably flexible and conforms to theelectrode body 360 such that theinsulator 362 does not impede desired shaping and re-shaping of theelectrode body 360 as previously described. - It will be understood that the preferred construction of the
shaft 322 to include theelongated electrode body 360 and theinsulator 362 is but one available configuration. Alternatively, theshaft 322 can be constructed of an electrode material forming thetip 344, and a rigid or malleable, non-conductive rod or tube rigidly connecting thetip 344 to thehandle 320. The non-conductive rod or tube can include one or more metal conductors, such as straight wire and/or windings for electrically connecting thetip 344 to thediagnostic device 316. Thetip 344 may be coated with one or more coatings. Another alternative embodiment includes construction of theshaft 322 to include one or more metal conductors, such as straight wire and/or windings inside a rigid or malleable non-conductive polymer tube. Theinsulator 362 may cover a portion of the wire or windings. - With respect to the above-described alternative embodiments, connection between the elongated rod or tube and the
separate tip 344 can be accomplished in a variety of manners. Once again, the elongated rod or tube can comprise a conductive or non-conductive material(s), such as metal(s) or plastic(s). The elongated rod or tube can be connected to thetip 344 via a variety of coupling techniques, including, for example, welding, laser welding, spin welding, crimping, gluing, soldering and press fitting. Alternatively, the distal end of the elongated rod or tube and thetip 344 can be configured to threadably engage one another and/or mechanical engagement member(s) (e.g., pins, screws, rivets, etc.) can be employed. In another embodiment, the elongated rod or tube is rigidly coupled to thetip 344. In yet another embodiment, thetip 344 can be moveably coupled to the elongated rod or tube, whereby thetip 344 can be moved and/or locked relative to the elongated rod or tube. For example, thetip 344 can be coupled to the elongated rod or tube via one or more joints or hinges. The joints or hinges can be ball joints and/or joints that include a pin. To this end, a pin-type joint can be configured to allow thetip 344 to swivel relative to the elongated rod or tube. Further, the joint(s) can be configured to move and lock into position. In addition, one or more actuators (e.g., knobs, buttons, levers, slides, etc.) can be located on, for example, the handle 320 (FIG. 1 ) for actuating the joint(s). With the above in mind,FIG. 18 illustrates a portion of analternative embodiment shaft 322′ including atip 344′ moveably coupled to an elongated rod ortube 363 by apin 364. - Returning to
FIG. 14 , themapping instrument 312 preferably includes acoupling member 365 for rigidly coupling theshaft 322 to thehandle 320. Thecoupling member 365 can comprise one or more polymers, plastics, and/or rubbers. For example, thecoupling member 365 can comprise one or more silicones, acrylics, nylons, polystyrenes, polyvinylchlorides, polycarbonates, polyurethanes, polyethylenes, polypropylenes, polyamides, polyethers, polyesters, polyolefins, polyacrylates, polyisoprenes, fluoropolymers, combinations thereof or the like. -
FIG. 19A depicts use of themapping system 310, and in particular themapping instrument 312, performing an assessment of transmurality of one ormore ablation lesions 78 created by an ablation tool, for exampleelectrosurgical instrument 12. Transmurality is achieved when the full thickness of the target tissue is ablated. In particular,FIG. 19A includes a representation of aheart 70 with itsleft atrium 72 exposed. Prior to use, themapping instrument 312 is provided to the surgeon (not shown) with theshaft 322 in the initial straight state (FIG. 14 ). The surgeon then evaluates the constraints presented by thetissue target site 74 and thelesion pattern 78 formed earlier by an ablation procedure. Following this evaluation, the surgeon determines an optimal shape of theshaft 322 most conducive to achieving the desired assessment. With this evaluation in mind, the surgeon then transitions or bends theshaft 322 from the initial straight state to the bent state illustrated inFIG. 19A . Once again, theshaft 322 is configured to independently maintain this selected shape. Theshaft 322 can be bent by hand and/or by use of bending jigs or tools. - Once the desired shape of the
shaft 322 has been achieved, thetip 344 is directed to thetissue target site 74. A grounding electrode (318 inFIG. 14 , but not shown inFIG. 19A ) is placed in contact with the patient. The grounding electrode may comprise a needle electrode and a cable for connection to thediagnostic device 316. Alternatively, a grounding wire may be coupled todiagnostic device 316 and a metal retractor coupled to the patient. For example, a metal sternal retractor used to spread a patient's ribs may be used as a grounding electrode. - If additional lesions are to be assessed, the surgeon again evaluates the target tissue site, and re-forms the
shaft 322 accordingly. Notably, theshaft 322 need not necessarily be bent to perform a tissue mapping/pacing procedure. Instead, thetip 344 can contact thetarget site tissue 74 with theshaft 322 in the initial straight state. In this regard, because theshaft 322 is straight and the handle 320 (FIG. 14 ) is preferably circumferentially uniform, themapping instrument 312 does not have a discernable use direction (as compared to theshaft 322 being bent or curved, whereby the curve inherently defines a most appropriate use direction). - In addition to the one exemplary procedure described above, the
mapping instrument 312 may be positioned and used, for example, through a thoracotomy, through a sternotomy, percutaneously, transveneously, endoscopically, for example, through a percutaneous port, through a stab wound or puncture, through a small incision, for example, in the chest or in the abdomen, or in combinations thereof. It is also contemplated that themapping instrument 312 may be used in other ways, for example, in open-chest surgery on a heart in which the sternum is split and the rib cage opened with a retractor. - The
mapping system 310, and in particular themapping instrument 312, described above with respect toFIG. 14 is but one acceptable configuration in accordance with the present invention. That is to say, thesystem 310 and/or theinstrument 312 can assume other forms and/or include additional features while still providing a mapping instrument having a shaft that independently maintains varying shapes associated with a straight state and a bent state, and is indifferent to rotational orientation in the straight state. - For example, the
mapping instrument 312 can include one or more surgeon-controlled switches. For example, a switch may be incorporated in or on themapping instrument 312 or any other location easily and quickly accessed by the surgeon for regulation of themapping instrument 312 by the surgeon. The switch may be, for example, a hand switch, a foot switch, or a voice-activated switch comprising voice-recognition technologies. One or more switches may be incorporated into thegrip portion 324 of themapping instrument 312. A switch incorporated into thegrip portion 324 may be a switch, such as a membrane switch, encompassing the entire circumference of themapping instrument 312, thereby effectively being indifferent to a rotational orientation when the surgeon grasps the handle. That is to say, due to the cross-sectional shape of the switch, themapping instrument 312 may be rotated to any position relative to a central axis A, and still be conveniently controlled by the surgeon. - Alternatively, a hand switch connected to the
mapping instrument 312, but not incorporated into themapping instrument 312, may be used. For example, a switch designed to be worn by a surgeon, for example on a surgeon's thumb, may be used to activate and/or deactivate themapping instrument 312. A switch may be incorporated into a cuff or strap that is placed on or around the thumb or finger of a surgeon. Alternatively, a switch may be designed to fit comfortably in a surgeon's palm. - One or more visual and/or audible signals used to alert a surgeon to the completion or resumption of a procedure, for example, may be incorporated into the
mapping instrument 312. For example, a beeping tone or flashing light that increases in frequency as the mapping/pacing period ends or begins may be used. Alternatively or in addition, an indicator light otherwise located on themapping instrument 312 can be inductively coupled to thediagnostic device 316 and adapted such that when power is being delivered to themapping instrument 312, the light is visible to the surgeon or other users. - An alternative embodiment,
mapping instrument 412 is provided inFIGS. 20A and 20D . Themapping instrument 412 is highly similar to the mapping instrument 312 (FIG. 14 ) previously described, and includes ahandle 420, ashaft 422 andwiring 428. Theshaft 422 is virtually identical to the shaft 322 (FIG. 14 ) previously described, and forms atip 444. Theshaft 422 is adapted to be bendable from a straight state (FIG. 20A ) to multiple bent states (one of which is illustrated inFIG. 20B ), with theshaft 422 independently maintaining a shape associated with the particular state. Similar to previous embodiments, thewiring 428 electrically couples the diagnostic device 316 (FIG. 14 ) to theshaft 422. - The
handle 420 varies from the handle 320 (FIG. 14 ) previously described in that thehandle 420 does not define a curved outer surface. Instead, thehandle 420 is hexagonal in transverse cross-section. This alternative configuration is, however, indifferent to rotational orientation when grasped by a user, thereby promoting the preferred ease of use feature previously described. Notably, thehandle 420 can alternatively be formed to a variety of other symmetrical transverse cross-sectional shapes (e.g., octagonal, etc.). - In yet another alternative embodiment, the mapping system 310 (
FIG. 14 ) further includes a controller (not shown) that can also gather and process information from themapping instrument 312 and/or one or more sensors or sensing elements such as temperature sensors or probes. For example, a temperature sensor coupled to the controller can be located in the distal section 342 (FIG. 14 ) of themapping instrument 312. The temperature sensor may be a thermocouple element that measures tissue temperature. Alternatively, the temperature sensor may be, for example, one or more thermisters, temperature-sensing liquid crystals, temperature-sensing chemicals, thermal cameras, and/or infrared (IR) fiber optics. - With the above in mind,
FIGS. 21A-21C depict a portion of an alternativeembodiment mapping device 640, and in particular adistal section 642 thereof. Themapping instrument 640 is highly similar to previous embodiments, and includes a shaft (not shown) terminating at an electricallyconductive tip 644. Further, themapping instrument 640 includes one ormore sensors 660, for example, a temperature probe for monitoring tissue temperature. Thesensor 660 may be placed at thetip 644. A ring ofinsulation material 663 may be used to electrically and thermally isolatesensor 660 from the electricallyconductive tip 644. The preferred central placement of thesensor 660 at thetip 644 allows thesensor 660 to directly contact a tissue surface in a number of orientations. Analternative embodiment sensor 660 may include an IR optical fiber system, for example, to monitor temperature based on IR. Thesensor 660 may be positioned adjacent tip 644 (not shown) or within tip 644 (FIGS. 21A-21C ). - Sensing
elements 660 can be coupled to visual and/or audible signals used to alert a surgeon to a variety of procedural conditions. For example, a beeping tone or flashing light that increases in frequency as temperature of the tissue exceeds a predetermined amount can be used. - In one embodiment,
diagnostic device 316 can incorporate one or more switches to facilitate regulation of various components of mapping system 310 (FIG. 14 ) by the surgeon. One example of such a switch is a foot pedal. The switch can also be, for example, a hand switch as described above, or a voice-activated switch comprising voice-recognition technologies. The switch can be incorporated in or on one of the surgeon's instruments, such as surgical site retractor, e.g., a sternal or rib retractor, or the mapping instrument 312 (FIG. 14 ), or any other location easily and quickly accessed by the surgeon. Thediagnostic device 316 can also include a display or other means of indicating the status of various components to the surgeon, such as a numerical display, gauges, a monitor display or audio feedback. - Finally, a visual and/or audible signal used to alert a surgeon to the completion or resumption of sensing, monitoring, pacing and/or mapping can be incorporated into the controller. For example, a beeping tone or flashing light that increases in frequency as the pacing period ends or begins can be provided.
- In yet another embodiment, and with general reference to
FIG. 14 , themapping instrument 312 and/or thediagnostic device 316 can be slaved to a robotic system or a robotic system may be slaved to themapping instrument 312 and/or thediagnostic device 316. - The handle and shaft of the mapping instrument of the present invention are configured to be indifferent to rotational orientation when initially presented to a surgeon. Subsequently, the surgeon can conveniently shape or bend the shaft so as to provide a shape most conducive to assessing the lesion pattern required by the particular surgical procedure. In this regard, the shaft independently maintains the selected shape throughout the particular mapping/pacing procedure. Subsequently, the shaft can be re-shaped back to a straight configuration, or to any other desired curvature.
- In one embodiment,
mapping instrument 312 may be used to pace the heart. For example,mapping instrument 312 may be connected to an external temporary pacemaker, e.g., the Medtronic External Temporary Pacemaker model 5388 or the Medtronic 2090/2290 Programmer/Analyzer.Mapping instrument 312 may be used to temporarily pace atrial tissue of the heart and/or ventricular tissue of the heart. For pacing the heart, tip 344 ofmapping instrument 312 is put into contact with tissue to be paced. For example, in one embodiment, a texturedball tip electrode 344 is placed into contact with atrial tissue (FIGS. 19A and 19B ). - In one embodiment, a pacing threshold for the
mapping instrument 312 for pacing atrial tissue is <10 mA @ 0.5 ms using the Medtronic 5388 pacemaker. Medtronic's 5388 pacemaker has a maximum output of 20 mA. Ablation lesion testing may be performed by finding the pacing threshold outside theisolated tissue area 74 and then placing the device inside theisolated tissue area 74, as shown inFIGS. 19A and 19B , with 2× the pacing threshold of the non-isolated area. A pacing threshold of 10 mA or less allows themapping instrument 312 to be used for typical lesion testing after cardiac ablation ofatrial tissue 78. Since the Medtronic 5388 device is a current controlled device, pacing threshold for the 5388 temporary pacemaker is the minimum current at which the temporary pacemaker continuously controls pacing of the heart. - The pacing threshold for the
mapping instrument 312 for pacing ventricle tissue is <5V @ 0.5 ms using Medtronic's 2090/2290 Programmer/Analyzer and the resistance at 5V preferably is >500Ω (5V/500Ω=10 mA). Pacing threshold for the Programmer/Analyzer is the lowest voltage at which continuous capture of the heart occurs.Mapping instrument 312 is used in a unipolar mode (measuring between thetip 344 and agrounding electrode 318, for example a grounding needle placed, for example, in the extrathoracic tissue). Pacing resistance can be measured at 5V while using the Programmer/Analyzer to measure pacing thresholds. - In one embodiment, the
mapping instrument 312 can be used in left sided epicardial lead placement procedures. During these procedures, epicardial mapping is useful in identifying the optimal site for epicardial lead placement on the left ventricle. In one embodiment, themapping instrument 312 is used to pace one or more ventricles and the synchronicity of left ventricular contraction is evaluated, for example, with TEE. Alternatively, tissue Doppler ultrasound may be used to measure contraction patterns and to locate the site where biventricular pacing could result in the most effective contraction of the left ventricle. While Doppler ultrasound may be may be more effective than TEE, it is not commonly available and may require the patient's chest to be closed in order to provide useful data. - Another approach entails identifying the site of latest left ventricular electrical activity following a paced right ventricular beat. This electrical site may correlate with the site of latest mechanical activity. Pacing at the site of latest activation can create two contraction wavefronts from electrically opposite sides of the heart while accommodating any unusual conduction pathways. Theoretically, this will create collision of the right and left ventricular wavefronts equidistant from the electrodes on both sides of the ventricle thereby minimizing dysynchrony. The hypothesis for this activation sequence was originally described more than 20 years ago.
FIG. 22 illustratesactivation patterns 390 and cell-to-cell conduction from right ventricular pacing by anelectrode 395 placed in the right ventricle. - The approach of identifying the site of latest left ventricular electrical activity determines the time between a paced event in the right ventricle and the corresponding sensed event in the left ventricle. As the heart is paced in the right ventricle, the
electrode tip 344 ofmapping instrument 312 is placed into contact of epicardial tissue of the left ventricle and the time at which a depolarization wave is sensed over the left ventricle is noted. - This timeframe is called the “paced depolarization interval” (PDI). Starting at a posterior lateral position, approximately six sites should be measured, see
FIG. 23 . The longest time interval or maximum PDI is the point that is electrically farthest from the right ventricular electrode and is generally the site for optimal lead placement. - Paced depolarization intervals will vary among patients. PDI values of normal hearts are usually 100 ms or less, but patients who have congestive heart failure and larger hearts typically have values between 150 ms and 200 ms. In general, the larger the heart, the larger the PDI. In addition, PDIs below 150 ms tend to indicate the lead location is not optimal.
- When measuring paced depolarization intervals, it is very important to use a paced beat rather than an intrinsic beat. A CRT system will pace both ventricles and the lead placement site should be chosen in accordance with the way the CRT system functions. Pacing of the right ventricle can be accomplished using either an implanted pacemaker or a programmer/analyzer, for example, the Medtronic 2090/2290 Programmer/Analyzer.
- If the patient already has an implanted pacemaker, it is not necessary to remove it or externalize the right ventricular lead prior to mapping for left ventricular lead placement. The pacemaker should be programmed to pace the right ventricle continuously in the unipolar mode. A 5V pacing pulse may be used to help visualization of the pacing spike on the mapping electrode signal.
Mapping instrument 312 should be connected to the programmer or other device to display electrograms (EGMs), which should either be frozen electronically in the programmer or printed on paper for manual measurement. From the EGM, the pacing spike should be seen, as should the depolarization wavefront that passes under the left ventricular mapping electrode. The time between the pacing spike and the depolarization wave on the EGM signal is the PDI. Maximizing the PDI may optimize cardiac resynchronization. - A Programmer/Analyzer, for example, the Medtronic 2090/2290 Programmer/Analyzer, may be used to measure the maximum PDI. If a right ventricular lead is not accessible, the mapping electrode can be connected to either the atrial or ventricular channel of the analyzer. The pacing spike and the depolarization wavefront should both be visible on the data strip, see
FIG. 24 . During this measurement, the right ventricular lead should be pacing the heart with the implanted pacemaker in the unipolar mode. The time can then be measured between the pacing spike and the left ventricular deflection. If the right ventricular lead is accessible, both leads can be connected to the analyzer. The right ventricular lead is connected to the ventricular channel and themapping instrument 312 is connected to the atrial channel. The analyzer can then pace the right ventricular lead, sense the left ventricular mapping electrode, and display the time between the paced and sensed events on the screen. In this case, the right ventricular (RV) and left ventricular (LV) EGMs shown inFIG. 25 will both be visible. The strips can be frozen electronically in the analyzer and the maximum PDI measured with calipers, or they can be printed on paper for manual measurement. - In another embodiment, the
electrosurgical instrument 12 includes a mode switch (not shown). For example, a surgeon-controlled mode switch may be incorporated in or on theelectrosurgical instrument 12 or any other location easily and quickly accessed by a surgeon for switching between an ablation mode, a mapping mode and/or a pacing mode. The switch may be, for example, a hand switch, a foot switch, or a voice-activated switch comprising voice-recognition technologies. A mode switch would allow theelectrosurgical instrument 12 to be used as both an ablation tool and a mapping/pacing tool. For example, an energy source may be electrically connected toelectrosurgical instrument 12, wherein the energy source comprises ablation energy for creating tissue lesions and stimulation energy for pacing the heart. A switch coupled to the energy source may be configured to control delivery of ablation energy and stimulation energy from the energy source toelectrosurgical instrument 12. The delivery of ablation energy toelectrosurgical instrument 12 may be stopped when the delivery of stimulation energy toelectrosurgical instrument 12 is started and the delivery of stimulation energy toelectrosurgical instrument 12 may be stopped when the delivery of ablation energy toelectrosurgical instrument 12 is started. The switch may also be coupled to a source of conductive fluid. In this case, the switch may be configured to control delivery of fluid from a source of conductive fluid to the internal lumen of the instrument. For example, the delivery of fluid to the internal lumen of the instrument may be stopped when the delivery of ablation energy to the tip of the instrument is stopped and the delivery of fluid to the internal lumen of the instrument may be started when the delivery of ablation energy to the tip of the instrument is started. - In yet another alternative embodiment, the
electrosurgical instrument 12 includes a visual and/or audible signaling device (not shown) used to alert a surgeon to any change in the mode of the device. For example, a beeping tone or flashing light can be used to alert the surgeon that theelectrosurgical instrument 12 is in an ablation mode or has changed from a mapping/pacing mode to an ablation mode. For example, one or more indicator lights located on the instrument can indicate the delivery of ablation energy and/or stimulation energy for pacing heart tissue. - Although the invention has been described above in connection with particular embodiments and examples, it will be appreciated by those skilled in the art that the invention is not necessarily so limited, and that numerous other embodiments, examples, uses, modifications and departures from the embodiments, examples and uses are intended to be encompassed by the claims attached hereto. The entire disclosure of each patent and publication cited herein is incorporated by reference, as if each such patent or publication were individually incorporated by reference herein.
Claims (31)
1. A system for pacing the heart comprising:
an instrument including:
an elongated shaft defining a proximal section and a distal section, wherein the distal section forms an electrically conductive rounded tip, and further wherein the shaft is adapted to be transitionable from a straight state to a first bent state, the shaft independently maintaining distinct shapes in the straight state and the first bent state, and a non-conductive handle rigidly coupled to the proximal section of the shaft; wherein an exterior of the shaft distal the handle and proximal the distal section is electrically non-conductive;
a grounding electrode; and
an energy source electrically connected to the tip and the grounding electrode, wherein the energy source comprises stimulation energy for pacing the heart.
2. The system of claim 1 , wherein the tip of the instrument defines a uniform radius of curvature.
3. The system of claim 1 , wherein in the straight state, the shaft of the instrument defines a linear axis, and further wherein in the first bent state, a portion of the shaft is deflected relative to the linear axis.
4. The system of claim 3 , wherein the shaft of the instrument is adapted to be transitionable to, and independently maintain a shape in, any direction relative to the linear axis.
5. The system of claim 1 , wherein the shaft of the instrument is capable of being bent at a multiplicity of points along a length thereof.
6. The system of claim 1 , wherein the shaft of the instrument is adapted to be transitionable to, and independently maintain a shape of, a second bent state different from the first bent state.
7. The system of claim 1 , wherein the instrument is adapted for stimulating cardiac tissue through a chest of a patient.
8. The system of claim 7 , wherein the cardiac tissue is atrial tissue.
9. The system of claim 7 , wherein the cardiac tissue is ventricular tissue.
10. The system of claim 7 , wherein the instrument is adapted for stimulating cardiac tissue endocardially through a chest of a patient.
11. The system of claim 7 , wherein the instrument is adapted for stimulating cardiac tissue epicardially through a chest of a patient.
12. The system of claim 1 , wherein the shaft of the instrument includes:
an elongated electrode body forming the proximal section and the distal section, the electrode body being directly coupled to the handle; and
an electrical insulator surrounding a portion of the electrode body.
13. The system of claim 12 , wherein the electrode body is formed of an electrically conductive, malleable material.
14. The system of claim 12 , wherein the electrical insulator is configured to conform to the electrode body in the straight state and the first bent state.
15. The system of claim 1 , wherein the shaft of the instrument comprises a joint adapted to permit the distal section of the shaft to move relative to the proximal section of the shaft.
16. The system of claim 15 , wherein the joint is a ball bearing joint adapted to allow the distal section of the shaft to rotate relative to the proximal section of the shaft.
17. The system of claim 15 , wherein the joint includes a pin such that the joint allows the distal section of the shaft to swivel relative to the proximal section of the shaft.
18. The system of claim 15 , further comprising a remote actuator configured to selectively control the joint.
19. The system of claim 1 , wherein the instrument is adapted for sensing a depolarization wave.
20. The system of claim 1 , wherein the grounding electrode is a needle electrode.
21-46. (canceled)
47. A method of performing an ablation procedure, the method comprising:
providing a first instrument including an elongated shaft and a handle, the shaft defining a proximal section rigidly coupled to the handle, a distal section forming an electrically conductive tip;
positioning the tip of the first instrument through a patient's chest;
applying ablation energy to the tip of the first instrument while contacting cardiac tissue;
creating an ablation lesion to isolate an area of cardiac tissue;
providing a second instrument including an elongated shaft and a handle, the shaft defining a proximal section rigidly coupled to the handle, a distal section forming an electrically conductive tip;
positioning the tip of the second instrument through a patient's chest; and
applying stimulation energy to the tip of the second instrument while contacting the area of isolated cardiac tissue to assess transmurality of the ablation lesion.
48. The method of claim 47 , wherein the first instrument further comprises an internal lumen extending from the proximal section of the shaft and in fluid communication with at least one passage formed in the distal section of the shaft.
49. The method of claim 48 , further comprising:
dispensing conductive fluid from the internal lumen of the shaft via the at least one passage.
50. The method of claim 47 , wherein the ablation energy is radiofrequency energy.
51. A method of performing an ablation procedure, the method comprising:
providing an instrument including an elongated shaft and a handle, the shaft defining a proximal section rigidly coupled to the handle, a distal section forming an electrically conductive tip;
positioning the tip through a patient's chest;
applying ablation energy to the tip while contacting cardiac tissue;
creating an ablation lesion to isolate an area of cardiac tissue;
stopping the application of ablation energy to the tip;
repositioning the tip; and
applying stimulation energy to the tip while contacting the area of isolated cardiac tissue to assess transmurality of the ablation lesion.
52. The method of claim 51 , wherein the instrument further comprises an internal lumen extending from the proximal section of the shaft and in fluid communication with at least one passage formed in the distal section of the shaft.
53. The method of claim 52 , further comprising:
dispensing conductive fluid from the internal lumen of the shaft via the at least one passage while applying ablation energy to the tip.
54. The method of claim 51 , wherein the ablation energy is radiofrequency energy.
55. A method of performing a left sided epicardial lead placement procedure, the method comprising:
providing an instrument including an elongated shaft and a handle, the shaft defining a proximal section rigidly coupled to the handle, a distal section forming an electrically conductive tip;
positioning the tip through a patient's chest to contact a first area of epicardial tissue of the patient's left ventricle;
applying stimulation energy to the patient's right ventricle;
recording the time at which a depolarization wave is sensed over the left ventricle following stimulation of the right ventricle;
repositioning the tip to contact a second area of epicardial tissue of the patient's left ventricle;
reapplying stimulation energy to the patient's right ventricle;
recording the time at which the depolarization wave is sensed over the left ventricle following restimulation of the right ventricle;
placing an epicardial lead in contact with the area of tissue that had the longest time interval at which the depolarization wave was sensed over the left ventricle following stimulation of the right ventricle.
56. A method of performing an ablation procedure, the method comprising:
providing an instrument including an elongated shaft and a handle, the shaft defining a proximal section rigidly coupled to the handle, a distal section forming an electrically conductive tip;
advancing the tip of the instrument through a patient's chest and into the patient's coronary sinus;
positioning the tip of the instrument in the patient's coronary sinus between an existing lesion encircling at least a portion of the patient's pulmonary veins and the annulus of the patient's mitral valve;
applying ablation energy to the tip of the instrument while the tip is positioned in the coronary sinus; and
creating an ablation lesion in an area of cardiac tissue surrounding the tip.
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US8623010B2 (en) | 2014-01-07 |
US7967816B2 (en) | 2011-06-28 |
EP1476093A1 (en) | 2004-11-17 |
US20030144656A1 (en) | 2003-07-31 |
WO2003063718A1 (en) | 2003-08-07 |
EP1476093A4 (en) | 2007-10-24 |
US20090326527A1 (en) | 2009-12-31 |
EP1476093B1 (en) | 2011-05-04 |
DE60336983D1 (en) | 2011-06-16 |
US20040267326A1 (en) | 2004-12-30 |
ATE507792T1 (en) | 2011-05-15 |
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