US20070100428A1 - Multiple-wing balloon catheter and membrane to reduce damage to coated expandable medical implants - Google Patents

Multiple-wing balloon catheter and membrane to reduce damage to coated expandable medical implants Download PDF

Info

Publication number
US20070100428A1
US20070100428A1 US11/634,160 US63416006A US2007100428A1 US 20070100428 A1 US20070100428 A1 US 20070100428A1 US 63416006 A US63416006 A US 63416006A US 2007100428 A1 US2007100428 A1 US 2007100428A1
Authority
US
United States
Prior art keywords
balloon
catheter
membrane
implant
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/634,160
Inventor
Tom Mc Hale
Jan Weber
Timothy O'Connor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Boston Scientific Scimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Scimed Inc filed Critical Boston Scientific Scimed Inc
Priority to US11/634,160 priority Critical patent/US20070100428A1/en
Publication of US20070100428A1 publication Critical patent/US20070100428A1/en
Assigned to SCIMED LIFE SYSTEMS, INC. reassignment SCIMED LIFE SYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: O'CONNOR, TIMOTHY, MCHALE, TOM, WEBER, JAN
Assigned to BOSTON SCIENTIFIC SCIMED, INC. reassignment BOSTON SCIENTIFIC SCIMED, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SCIMED LIFE SYSTEMS, INC.
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1027Making of balloon catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958Inflatable balloons for placing stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1002Balloon catheters characterised by balloon shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1027Making of balloon catheters
    • A61M25/1038Wrapping or folding devices for use with balloon catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1002Balloon catheters characterised by balloon shape
    • A61M2025/1004Balloons with folds, e.g. folded or multifolded

Definitions

  • the present invention relates to methods and systems for deploying coated expandable medical implants. More particularly the present invention regards methods and systems that employ a multi-wing balloon catheter for deploying a coated medical implant at a target site. Background
  • Expandable medical implants are positioned and placed in the body during the completion of numerous contemporary medical procedures. These implants may include stents, vena-cava filters, and aneurism coils and may be used for innumerable purposes including reinforcing damaged vessels, replacing ruptured vessels, and delivering therapeutic to a target site in the body. This therapeutic may be delivered via coatings placed in, on, and around the implants as well as through various other means and methods.
  • the coating can be damaged both during assembly and, afterwards, during the actual medical procedure.
  • the coating is routinely at risk of damage. For instance, during the crimping of balloon expandable stents onto their carrier balloon catheters, large compressive forces are exerted onto the coating of the stent in order to secure the stent to the balloon.
  • an expandable stent is often delivered by a balloon catheter that is expanded after the catheter reaches the target site.
  • a balloon catheter that is expanded after the catheter reaches the target site.
  • shear and torsional forces are placed on the coating by the expanding balloon.
  • These forces can be counterproductive if too large because they can tear the coating away from and off of the stent. This tearing away can cause the therapeutic to be haphazardly adhered to the stent and, thus, reduce its effectiveness.
  • the method may include providing a coated medical implant, providing a balloon catheter having a multi-wing balloon, the multi-wing balloon having at least four expandable folds, and crimping the coated implant onto the multi-wing balloon.
  • the system may include a coated medical implant and a multi-wing balloon catheter having at least four expandable wings, the expandable wings in contact with the coating of the medical implant.
  • FIG. 1 is a cross-sectional view of a multi-wing balloon catheter carrying a coated implant in its pre-inflation state.
  • FIG. 2 is a cross-sectional view of the multi-wing balloon catheter of FIG. 1 after the balloon has begun to be inflated.
  • FIG. 3 is a cross-sectional view of the multi-wing balloon catheter of FIG. 1 wherein the balloon is in a semi-inflated condition.
  • FIG. 4 is a cross-sectional view of the multi-wing balloon catheter of FIG. 1 in a fully inflated condition.
  • FIG. 5 is a cross-sectional view of a multi-wing catheter employing an expandable deformable membrane in accord with an alternative embodiment of the present invention.
  • FIG. 1 is a cross-sectional view of the working end of a multi-wing balloon catheter in accord with one embodiment of the present invention.
  • the multi-wing balloon 10 expandable folds 11 , and internal lumen 12 of the catheter can all be seen.
  • a medical implant 14 with a coating 13 , the implant 14 being placed around the multi-wing balloon 10 .
  • the multi-wing balloon 10 in this embodiment may be used to deliver the implant 14 to numerous target sites both inside and outside of the human body.
  • a fluid may be forced down the internal lumen 12 to the multi-wing balloon 10 to inflate the multi-wing balloon 10 .
  • the balloon 10 may begin to expand both near its core and out at its peripheral folds 11 .
  • the multi-wing balloon 10 expands it may exert a force on the implant 14 via the expandable folds 11 that may be in contact with the coating 13 of the implant 14 . Due to the orientation of the folds 11 in this embodiment the folds may place both compressive and shear forces on the coating 13 during expansion.
  • the compressive force are mostly associated with the expansion of the implant while the shear forces largely stem from the skimming of the folds over the surface of the coating during expansion.
  • the number of folds can be increased or can be reduced to four.
  • the number of folds 11 the magnitude of the forces that each fold places on the coating can be reduced.
  • the distance that each fold may have to travel may be reduced.
  • increasing the number of folds can reduce the torsional forces placed on the implant during expansion.
  • the time needed to inflate the balloon may also be reduced due to the smaller internal volume of each of the folds.
  • the number of folds can be chosen to conform with or correlate with the number of cells in the implant.
  • the amount of pinpoint loads placed on the implant by the balloon can be better controlled and regulated. For instance, if the implant were a stent that had five cells positioned next to each other to form a ring, the balloon may have five folds such that one fold may touch the interface between each of the cells and exert a force thereon during the expansion of the stent.
  • the coating 13 employed is resilient enough to resist the forces that will be placed upon it by the five expandable folds 11 during the expansion of the multi-wing balloon 10 .
  • the coating 13 is unable to resist damage during expansion the number of expandable folds 11 can be increased (as described above) or the coating 13 may be modified or changed to better accommodate the inflating forces placed upon it.
  • its properties at both ambient temperature and within the body should preferably be considered in order to avoid the situation where the coating remains intact if the balloon is inflated outside of the body but is removed if the balloon is inflated within the body.
  • FIG. 2 is a cross-sectional view of the multi-wing balloon from FIG. 1 after the expandable folds 11 have begun to inflate and after they have begun to expand the implant 14 .
  • the arrows 20 indicate the path of rotation of the expandable folds as they inflate and push the implant 14 out.
  • the folds 11 travel in a counter-clockwise direction in this embodiment. Alternatively, in a different embodiment, they could travel in a clockwise direction.
  • the coating 13 has not been substantially removed by the expansive forces of the folds although some slight repositioning and damage to the coating may have occurred.
  • FIG. 3 is a cross-section of the multi-wing balloon 10 after it has been partially inflated.
  • the main portion of the balloon has grown larger and the folds 11 are no longer rotating within the implant 14 as in the earlier figures but have, instead, reached their fully extended position.
  • An advantage of the multiple folds 11 in this embodiment is the multiple contact points that they present during this stage of the expansion. By having five contact points with the coating 13 , the coating 13 is less likely to be damaged during this phase of the expansion. Moreover, by increasing the number of folds, the unwanted expansion forces, associated with the nonuniform expansion of the implant along its longitudinal axis may be reduced. For instance, by increasing the number of folds, the angle by which the folds have to unfold during expansion is reduced, thereby further decreasing the forces that are placed on the implant during expansion. Likewise, by increasing the number of folds the risk of the balloon twisting and exerting torsional forces on the implant during expansion of the balloon is also reduced.
  • FIG. 4 is a cross-section of the multi-wing balloon from the earlier figures after it has been fully expanded. As is visible in FIG. 4 the coating 13 has remained substantially intact and both the balloon 10 and the implant 14 are larger than they were when the inflation process began. When being used in a medical procedure, after the implant has been enlarged to its desired size the balloon may then be deflated and removed from the implant, thereby leaving the implant at the target site.
  • the implant 14 may be any one of the numerous medical implants deployed at a target site by a balloon catheter including a stent.
  • the coating 13 may also be one of various available coatings known to one of skill in the art used to coat these implants including a therapeutic agent, a biocompatible polymer, and a combination of both.
  • the coating may be used to not only carry or transport therapeutic but also to facilitate the acceptance of the implant at the target site and to facilitate the rehabilitation of the target site.
  • FIG. 5 is an alternative embodiment of the present invention.
  • the balloon 50 is surrounded by an elastic membrane 52 .
  • This membrane 52 may further reduce the destructive forces that can be placed on the coating 13 of a medical implant during its expansion. It is on top of this membrane 52 that a coated medical implant may be placed.
  • This membrane 52 may be coated both on its inside and its outside in order to reduce the forces that may be generated between the membrane and the balloon and between the membrane and the implant.
  • FIG. 5 also shows the lumen 53 , which may be used to inflate and deflate the balloon, located within the balloon 50 as well as arrows 51 , which indicate the direction the folds 54 will rotate during the expansion of the balloon 50 .
  • the elastic membrane 52 may be made from latex as well as from other elastic materials. It is preferable that the membrane 52 be easily expandable as not to add a significant load to the balloon 50 during expansion. It is also preferable that the membrane be compatible with the coating so that it does not react or otherwise spoil the coating that may come in contact with it.
  • the balloon may also be treated to reduce the friction between it and the implant that it will deliver.
  • This treatment may include coating the balloon, heating the balloon to reduce its surface profile and polishing the balloon, also to reduce its surface profile.
  • the coatings employed may contain a therapeutic such as, for example: pharmaceutically active compounds, proteins, cells, oligonucleotides, ribozymes, anti-sense oligonucleotides, DNA compacting agents, gene/vector systems (i.e., any vehicle that allows for the uptake and expression of nucleic acids), nucleic acids (including, for example, recombinant nucleic acids; naked DNA, cDNA, RNA; genomic DNA, cDNA or RNA in a non-infectious vector or in a viral vector and which further may have attached peptide targeting sequences; antisense nucleic acid (RNA or DNA); and DNA chimeras which include gene sequences and encoding for ferry proteins such as membrane translocating sequences (“MTS”) and herpes simplex virus-1 (“VP22”)), and viral, liposomes and cationic and anionic polymers and neutral polymers that are selected from a number of types depending on the desired application.
  • a therapeutic such as, for example: pharmaceutically active
  • Non-limiting examples of virus vectors or vectors derived from viral sources include adenoviral vectors, herpes simplex vectors, papilloma vectors, adeno-associated vectors, retroviral vectors, and the like.
  • Non-limiting examples of biologically active solutes include anti-thrombogenic agents such as heparin, heparin derivatives, urokinase, and PPACK (dextrophenylalanine proline arginine chloromethylketone); antioxidants such as probucol and retinoic acid; angiogenic and anti-angiogenic agents and factors; agents blocking smooth muscle cell proliferation such as rapamycin, angiopeptin, and monoclonal antibodies capable of blocking smooth muscle cell proliferation; anti-inflammatory agents such as dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, acetyl salicylic acid, and mesalamine; calcium entry blockers
  • Cells can be of human origin (autologous or allogenic) or from an animal source (xenogeneic), genetically engineered if desired to deliver proteins of interest at the injection site.
  • the delivery mediated is formulated as needed to maintain cell function and viability. Any modifications are routinely made by one skilled in the art.
  • Polynucleotide sequences useful in practice of the invention include DNA or RNA sequences having a therapeutic effect after being taken up by a cell.
  • therapeutic polynucleotides include anti-sense DNA and RNA; DNA coding for an anti-sense RNA; or DNA coding for tRNA or rRNA to replace defective or deficient endogenous molecules.
  • the polynucleotides of the invention can also code for therapeutic proteins or polypeptides.
  • a polypeptide is understood to be any translation product of a polynucleotide regardless of size, and whether glycosylated or not.
  • Therapeutic proteins and polypeptides include as a primary example, those proteins or polypeptides that can compensate for defective or deficient species in an animal, or those that act through toxic effects to limit or remove harmful cells from the body.
  • the polypeptides or proteins that can be injected, or whose DNA can be incorporated include without limitation, angiogenic factors and other molecules competent to induce angiogenesis, including acidic and basic fibroblast growth factors, vascular endothelial growth factor, hif-1, epidermal growth factor, transforming growth factor ⁇ and ⁇ , platelet-derived endothelial growth factor, platelet-derived growth factor, tumor necrosis factor ⁇ , hepatocyte growth factor and insulin like growth factor; growth factors; cell cycle inhibitors including CDK inhibitors; anti-restenosis agents, including p15, p16, p18, p19, p21, p27, p53, p57, Rb, nFkB and E2F decoys, thymidine kina
  • MCP-1 monocyte chemoattractant protein
  • BMP's the family of bone morphogenic proteins
  • the known proteins include BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 (Vgr-1), BMP-7 (OP-1), BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, and BMP-16.
  • BMP's are any of BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 and BMP-7.
  • dimeric proteins can be provided as homodimers, heterodimers, or combinations thereof, alone or together with other molecules.
  • molecules capable of inducing an upstream or downstream effect of a BMP can be provided.
  • Such molecules include any of the “hedgehog” proteins, or the DNA's encoding them.
  • therapeutic agents can be used, for example, in any application for treating, preventing, or otherwise affecting the course of a disease or tissue or organ dysfunction.
  • the embodiments of the invention can be used to induce or inhibit angiogenesis, as desired, to prevent or treat restenosis, to treat a cardiomyopathy or other dysfunction of the heart, for treating Parkinson's disease or a stroke or other dysfunction of the brain, for treating cystic fibrosis or other dysfunction of the lung, for treating or inhibiting malignant cell proliferation, for treating any malignancy, and for inducing nerve, blood vessel or tissue regeneration in a particular tissue or organ.
  • Suitable biocompatible polymers for use in the present invention can be hydrophilic or hydrophobic, and can include, but are not limited to, polycarboxylic acids, cellulosic polymers, including cellulose acetate and cellulose nitrate, gelatin, polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, hydrogels, polyanhydrides including maleic anhydride polymers, polyamides, polyvinyl alcohols, copolymers of vinyl monomers such as EVA, polyvinyl ethers, polyvinyl aromatics, polyethylene oxides, glycosaminoglycans, polysaccharides, ethylene vinylacetate, polyesters including polyethylene terephthalate, polyacrylamides, polyethers, polyether sulfone, polycarbonate, polyalkylenes including polypropylene, polyethylene and high molecular weight polyethylene, halogen

Abstract

System for reducing the damage to a coated medical implant during the expansion of the coated implant is provided. The system may include a coated medical implant, a multi-wing balloon catheter having at least four expandable wings, and an expandable membrane positioned between the balloon and the medical implant.

Description

    RELATED APPLICATION
  • This application is a continuation of and claims priority to U.S. patent application Ser. No. 10/035,218, which has issued as U.S. patent. The '218 application, in its entirety, is incorporated by reference into this application.
  • FIELD OF THE INVENTION
  • The present invention relates to methods and systems for deploying coated expandable medical implants. More particularly the present invention regards methods and systems that employ a multi-wing balloon catheter for deploying a coated medical implant at a target site. Background
  • Expandable medical implants are positioned and placed in the body during the completion of numerous contemporary medical procedures. These implants may include stents, vena-cava filters, and aneurism coils and may be used for innumerable purposes including reinforcing damaged vessels, replacing ruptured vessels, and delivering therapeutic to a target site in the body. This therapeutic may be delivered via coatings placed in, on, and around the implants as well as through various other means and methods.
  • When, for example, the therapeutic is delivered by a coated expandable implant, the coating can be damaged both during assembly and, afterwards, during the actual medical procedure. When an implant having a therapeutic coating is being assembled, the coating is routinely at risk of damage. For instance, during the crimping of balloon expandable stents onto their carrier balloon catheters, large compressive forces are exerted onto the coating of the stent in order to secure the stent to the balloon.
  • Even after a stent has been crimped onto a catheter, the coating is also at risk of being damaged during the delivery of the stent. For example, an expandable stent is often delivered by a balloon catheter that is expanded after the catheter reaches the target site. At a target site, when the stent is being deployed, as the balloon is expanded and both shear and torsional forces are placed on the coating by the expanding balloon. These forces can be counterproductive if too large because they can tear the coating away from and off of the stent. This tearing away can cause the therapeutic to be haphazardly adhered to the stent and, thus, reduce its effectiveness.
  • SUMMARY OF THE INVENTION
  • Method and system for reducing the damage to a coated medical implant during the expansion of the coated implant is provided. The method may include providing a coated medical implant, providing a balloon catheter having a multi-wing balloon, the multi-wing balloon having at least four expandable folds, and crimping the coated implant onto the multi-wing balloon. The system may include a coated medical implant and a multi-wing balloon catheter having at least four expandable wings, the expandable wings in contact with the coating of the medical implant.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a cross-sectional view of a multi-wing balloon catheter carrying a coated implant in its pre-inflation state.
  • FIG. 2 is a cross-sectional view of the multi-wing balloon catheter of FIG. 1 after the balloon has begun to be inflated.
  • FIG. 3 is a cross-sectional view of the multi-wing balloon catheter of FIG. 1 wherein the balloon is in a semi-inflated condition.
  • FIG. 4 is a cross-sectional view of the multi-wing balloon catheter of FIG. 1 in a fully inflated condition.
  • FIG. 5 is a cross-sectional view of a multi-wing catheter employing an expandable deformable membrane in accord with an alternative embodiment of the present invention.
  • DETAILED DESCRIPTION
  • FIG. 1 is a cross-sectional view of the working end of a multi-wing balloon catheter in accord with one embodiment of the present invention. In FIG. 1 the multi-wing balloon 10, expandable folds 11, and internal lumen 12 of the catheter can all be seen. Also visible in FIG. 1 is a medical implant 14 with a coating 13, the implant 14 being placed around the multi-wing balloon 10.
  • The multi-wing balloon 10 in this embodiment may be used to deliver the implant 14 to numerous target sites both inside and outside of the human body. During its use a fluid may be forced down the internal lumen 12 to the multi-wing balloon 10 to inflate the multi-wing balloon 10. As more fluid is injected into the multi-wing balloon 10 the balloon 10 may begin to expand both near its core and out at its peripheral folds 11. As the multi-wing balloon 10 expands it may exert a force on the implant 14 via the expandable folds 11 that may be in contact with the coating 13 of the implant 14. Due to the orientation of the folds 11 in this embodiment the folds may place both compressive and shear forces on the coating 13 during expansion. The compressive force are mostly associated with the expansion of the implant while the shear forces largely stem from the skimming of the folds over the surface of the coating during expansion.
  • In this embodiment, five expandable folds extend from the main body of the balloon 10, however, in other embodiments, the number of folds can be increased or can be reduced to four. By increasing the number of folds 11 the magnitude of the forces that each fold places on the coating can be reduced. Moreover, as the number of folds 11 increases the distance that each fold may have to travel may be reduced. Thus, increasing the number of folds can reduce the torsional forces placed on the implant during expansion. In addition, by increasing the number of folds the time needed to inflate the balloon may also be reduced due to the smaller internal volume of each of the folds.
  • In an alternative embodiment, the number of folds can be chosen to conform with or correlate with the number of cells in the implant. By regulating the number of folds in the balloon in relation to the number of cells in the implant, the amount of pinpoint loads placed on the implant by the balloon can be better controlled and regulated. For instance, if the implant were a stent that had five cells positioned next to each other to form a ring, the balloon may have five folds such that one fold may touch the interface between each of the cells and exert a force thereon during the expansion of the stent.
  • In the embodiment of FIG. 1, it is preferable that the coating 13 employed is resilient enough to resist the forces that will be placed upon it by the five expandable folds 11 during the expansion of the multi-wing balloon 10. Alternatively, if the coating 13 is unable to resist damage during expansion the number of expandable folds 11 can be increased (as described above) or the coating 13 may be modified or changed to better accommodate the inflating forces placed upon it. In each situation, when the resiliency of the coating is being evaluated, its properties at both ambient temperature and within the body should preferably be considered in order to avoid the situation where the coating remains intact if the balloon is inflated outside of the body but is removed if the balloon is inflated within the body.
  • FIG. 2 is a cross-sectional view of the multi-wing balloon from FIG. 1 after the expandable folds 11 have begun to inflate and after they have begun to expand the implant 14. The arrows 20 indicate the path of rotation of the expandable folds as they inflate and push the implant 14 out. As can be seen, the folds 11 travel in a counter-clockwise direction in this embodiment. Alternatively, in a different embodiment, they could travel in a clockwise direction.
  • Also visible in FIG. 2 is the coating 13. As can be seen the coating 13 has not been substantially removed by the expansive forces of the folds although some slight repositioning and damage to the coating may have occurred.
  • FIG. 3 is a cross-section of the multi-wing balloon 10 after it has been partially inflated. In FIG. 3 the main portion of the balloon has grown larger and the folds 11 are no longer rotating within the implant 14 as in the earlier figures but have, instead, reached their fully extended position.
  • An advantage of the multiple folds 11 in this embodiment is the multiple contact points that they present during this stage of the expansion. By having five contact points with the coating 13, the coating 13 is less likely to be damaged during this phase of the expansion. Moreover, by increasing the number of folds, the unwanted expansion forces, associated with the nonuniform expansion of the implant along its longitudinal axis may be reduced. For instance, by increasing the number of folds, the angle by which the folds have to unfold during expansion is reduced, thereby further decreasing the forces that are placed on the implant during expansion. Likewise, by increasing the number of folds the risk of the balloon twisting and exerting torsional forces on the implant during expansion of the balloon is also reduced.
  • FIG. 4 is a cross-section of the multi-wing balloon from the earlier figures after it has been fully expanded. As is visible in FIG. 4 the coating 13 has remained substantially intact and both the balloon 10 and the implant 14 are larger than they were when the inflation process began. When being used in a medical procedure, after the implant has been enlarged to its desired size the balloon may then be deflated and removed from the implant, thereby leaving the implant at the target site.
  • The implant 14 may be any one of the numerous medical implants deployed at a target site by a balloon catheter including a stent. The coating 13 may also be one of various available coatings known to one of skill in the art used to coat these implants including a therapeutic agent, a biocompatible polymer, and a combination of both. In addition, the coating may be used to not only carry or transport therapeutic but also to facilitate the acceptance of the implant at the target site and to facilitate the rehabilitation of the target site.
  • FIG. 5 is an alternative embodiment of the present invention. In the embodiment of FIG. 5 the balloon 50 is surrounded by an elastic membrane 52. This membrane 52 may further reduce the destructive forces that can be placed on the coating 13 of a medical implant during its expansion. It is on top of this membrane 52 that a coated medical implant may be placed. This membrane 52 may be coated both on its inside and its outside in order to reduce the forces that may be generated between the membrane and the balloon and between the membrane and the implant.
  • FIG. 5 also shows the lumen 53, which may be used to inflate and deflate the balloon, located within the balloon 50 as well as arrows 51, which indicate the direction the folds 54 will rotate during the expansion of the balloon 50. The elastic membrane 52 may be made from latex as well as from other elastic materials. It is preferable that the membrane 52 be easily expandable as not to add a significant load to the balloon 50 during expansion. It is also preferable that the membrane be compatible with the coating so that it does not react or otherwise spoil the coating that may come in contact with it.
  • In addition to using an elastic membrane or in place of it the balloon may also be treated to reduce the friction between it and the implant that it will deliver. This treatment may include coating the balloon, heating the balloon to reduce its surface profile and polishing the balloon, also to reduce its surface profile.
  • The coatings employed may contain a therapeutic such as, for example: pharmaceutically active compounds, proteins, cells, oligonucleotides, ribozymes, anti-sense oligonucleotides, DNA compacting agents, gene/vector systems (i.e., any vehicle that allows for the uptake and expression of nucleic acids), nucleic acids (including, for example, recombinant nucleic acids; naked DNA, cDNA, RNA; genomic DNA, cDNA or RNA in a non-infectious vector or in a viral vector and which further may have attached peptide targeting sequences; antisense nucleic acid (RNA or DNA); and DNA chimeras which include gene sequences and encoding for ferry proteins such as membrane translocating sequences (“MTS”) and herpes simplex virus-1 (“VP22”)), and viral, liposomes and cationic and anionic polymers and neutral polymers that are selected from a number of types depending on the desired application. Non-limiting examples of virus vectors or vectors derived from viral sources include adenoviral vectors, herpes simplex vectors, papilloma vectors, adeno-associated vectors, retroviral vectors, and the like. Non-limiting examples of biologically active solutes include anti-thrombogenic agents such as heparin, heparin derivatives, urokinase, and PPACK (dextrophenylalanine proline arginine chloromethylketone); antioxidants such as probucol and retinoic acid; angiogenic and anti-angiogenic agents and factors; agents blocking smooth muscle cell proliferation such as rapamycin, angiopeptin, and monoclonal antibodies capable of blocking smooth muscle cell proliferation; anti-inflammatory agents such as dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, acetyl salicylic acid, and mesalamine; calcium entry blockers such as verapamil, diltiazem and nifedipine; antineoplastic/antiproliferative/anti-mitotic agents such as paclitaxel, 5-fluorouracil, methotrexate, doxorubicin, daunorubicin, cyclosporine, cisplatin, vinblastine, vincristine, epothilones, endostatin, angiostatin and thymidine kinase inhibitors; antimicrobials such as triclosan, cephalosporins, aminoglycosides, and nitorfurantoin; anesthetic agents such as lidocaine, bupivacaine, and ropivacaine; nitric oxide (NO) donors such as lisidomine, molsidomine, L-arginine, NO-protein adducts, NO-carbohydrate adducts, polymeric or oligomeric NO adducts; anti-coagulants such as D-Phe-Pro-Arg chloromethyl ketone, an RGD peptide-containing compound, heparin, antithrombin compounds, platelet receptor antagonists, anti-thrombin antibodies, anti-platelet receptor antibodies, enoxaparin, hirudin, Warafin sodium, Dicumarol, aspirin, prostaglandin inhibitors, platelet inhibitors and tick antiplatelet factors; vascular cell growth promotors such as growth factors, growth factor receptor antagonists, transcriptional activators, and translational promotors; vascular cell growth inhibitors such as growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors, translational repressors, replication inhibitors, inhibitory antibodies, antibodies directed against growth factors, bifunctional molecules consisting of a growth factor and a cytotoxin, bifunctional molecules consisting of an antibody and a cytotoxin; cholesterol-lowering agents; vasodilating agents; agents which interfere with endogeneus vascoactive mechanisms; survival genes which protect against cell death, such as anti-apoptotic Bcl-2 family factors and Akt kinase; and combinations thereof. Cells can be of human origin (autologous or allogenic) or from an animal source (xenogeneic), genetically engineered if desired to deliver proteins of interest at the injection site. The delivery mediated is formulated as needed to maintain cell function and viability. Any modifications are routinely made by one skilled in the art.
  • Polynucleotide sequences useful in practice of the invention include DNA or RNA sequences having a therapeutic effect after being taken up by a cell. Examples of therapeutic polynucleotides include anti-sense DNA and RNA; DNA coding for an anti-sense RNA; or DNA coding for tRNA or rRNA to replace defective or deficient endogenous molecules. The polynucleotides of the invention can also code for therapeutic proteins or polypeptides. A polypeptide is understood to be any translation product of a polynucleotide regardless of size, and whether glycosylated or not. Therapeutic proteins and polypeptides include as a primary example, those proteins or polypeptides that can compensate for defective or deficient species in an animal, or those that act through toxic effects to limit or remove harmful cells from the body. In addition, the polypeptides or proteins that can be injected, or whose DNA can be incorporated, include without limitation, angiogenic factors and other molecules competent to induce angiogenesis, including acidic and basic fibroblast growth factors, vascular endothelial growth factor, hif-1, epidermal growth factor, transforming growth factor α and β, platelet-derived endothelial growth factor, platelet-derived growth factor, tumor necrosis factor α, hepatocyte growth factor and insulin like growth factor; growth factors; cell cycle inhibitors including CDK inhibitors; anti-restenosis agents, including p15, p16, p18, p19, p21, p27, p53, p57, Rb, nFkB and E2F decoys, thymidine kinase (“TK”) and combinations thereof and other agents useful for interfering with cell proliferation, including agents for treating malignancies; and combinations thereof. Still other useful factors, which can be provided as polypeptides or as DNA encoding these polypeptides, include monocyte chemoattractant protein (“MCP-1”), and the family of bone morphogenic proteins (“BMP's”). The known proteins include BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 (Vgr-1), BMP-7 (OP-1), BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, and BMP-16. Currently preferred BMP's are any of BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 and BMP-7. These dimeric proteins can be provided as homodimers, heterodimers, or combinations thereof, alone or together with other molecules. Alternatively or, in addition, molecules capable of inducing an upstream or downstream effect of a BMP can be provided. Such molecules include any of the “hedgehog” proteins, or the DNA's encoding them.
  • These therapeutic agents can be used, for example, in any application for treating, preventing, or otherwise affecting the course of a disease or tissue or organ dysfunction. For example, the embodiments of the invention can be used to induce or inhibit angiogenesis, as desired, to prevent or treat restenosis, to treat a cardiomyopathy or other dysfunction of the heart, for treating Parkinson's disease or a stroke or other dysfunction of the brain, for treating cystic fibrosis or other dysfunction of the lung, for treating or inhibiting malignant cell proliferation, for treating any malignancy, and for inducing nerve, blood vessel or tissue regeneration in a particular tissue or organ.
  • The coatings employed may also contain or be solely composed of various suitable polymers either alone or in combination with the above therapeutics. Suitable biocompatible polymers for use in the present invention can be hydrophilic or hydrophobic, and can include, but are not limited to, polycarboxylic acids, cellulosic polymers, including cellulose acetate and cellulose nitrate, gelatin, polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, hydrogels, polyanhydrides including maleic anhydride polymers, polyamides, polyvinyl alcohols, copolymers of vinyl monomers such as EVA, polyvinyl ethers, polyvinyl aromatics, polyethylene oxides, glycosaminoglycans, polysaccharides, ethylene vinylacetate, polyesters including polyethylene terephthalate, polyacrylamides, polyethers, polyether sulfone, polycarbonate, polyalkylenes including polypropylene, polyethylene and high molecular weight polyethylene, halogenated polyalkylenes including polytetrafluoroethylene, polyurethanes, polyorthoesters, proteins, polypeptides, silicones, siloxane polymers, polylactic acid, polyglycolic acid, polycaprolactone, polyhydroxybutyrate valerate and blends and copolymers thereof as well as other biodegradable, bioabsorbable and biostable polymers and copolymers.
  • While various embodiments of the present invention have been disclosed herein other embodiments are also plausible without straying from the spirit and scope of the present invention.

Claims (13)

1. A balloon catheter and medical implant system comprising:
a catheter having an expandable balloon at a distal end of the catheter, the balloon having a plurality of expandable folds;
an elastic membrane positioned around the expandable balloon, the elastic membrane having a coating on at least one of its surfaces; and
an expandable medical implant positioned around the elastic membrane, the expandable medical implant having a coating on an internal surface facing the elastic membrane.
2. The catheter and implant system of claim 1 wherein the elastic membrane is coated on an inside surface and an outside surface.
3. The catheter and implant system of claim 1 wherein the coating of the expandable medical implant contains a therapeutic.
4. The catheter and implant system of claim 1 wherein the membrane comprises latex.
5. The catheter and implant system of claim 1 wherein the expandable balloon has a polished surface.
6. The catheter and implant system of claim 1 wherein the membrane has a uniform thickness.
7. The catheter and implant system of claim 1 wherein the membrane defines an unbroken tube around the balloon.
8. The catheter and implant system of claim 7 wherein the internal surface of the membrane is continuous and uniform.
9. The catheter and implant system of claim 1 wherein the expandable folds of the balloon rotate as the balloon expands.
10. The catheter and implant system of claim 1 wherein the balloon has five expandable folds.
11. The catheter and implant system of claim 1 wherein the coating of the medical implant is in contact with the coating of the membrane.
12. The catheter and implant system of claim 1 wherein the coating membrane is coated on an internal surface facing the balloon and an external surface facing the medical implant.
13. The catheter and implant system of claim 1 wherein the membrane is deformable.
US11/634,160 2002-01-04 2006-12-06 Multiple-wing balloon catheter and membrane to reduce damage to coated expandable medical implants Abandoned US20070100428A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/634,160 US20070100428A1 (en) 2002-01-04 2006-12-06 Multiple-wing balloon catheter and membrane to reduce damage to coated expandable medical implants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/035,218 US7160317B2 (en) 2002-01-04 2002-01-04 Multiple-wing balloon catheter to reduce damage to coated expandable medical implants
US11/634,160 US20070100428A1 (en) 2002-01-04 2006-12-06 Multiple-wing balloon catheter and membrane to reduce damage to coated expandable medical implants

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/035,218 Continuation US7160317B2 (en) 2002-01-04 2002-01-04 Multiple-wing balloon catheter to reduce damage to coated expandable medical implants

Publications (1)

Publication Number Publication Date
US20070100428A1 true US20070100428A1 (en) 2007-05-03

Family

ID=21881354

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/035,218 Expired - Fee Related US7160317B2 (en) 2002-01-04 2002-01-04 Multiple-wing balloon catheter to reduce damage to coated expandable medical implants
US11/634,160 Abandoned US20070100428A1 (en) 2002-01-04 2006-12-06 Multiple-wing balloon catheter and membrane to reduce damage to coated expandable medical implants

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/035,218 Expired - Fee Related US7160317B2 (en) 2002-01-04 2002-01-04 Multiple-wing balloon catheter to reduce damage to coated expandable medical implants

Country Status (8)

Country Link
US (2) US7160317B2 (en)
EP (2) EP1461111B1 (en)
JP (1) JP4663236B2 (en)
AU (2) AU2002352718A1 (en)
CA (2) CA2472451A1 (en)
DE (2) DE60223611T2 (en)
MX (1) MXPA04006570A (en)
WO (2) WO2003059430A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108778392A (en) * 2016-03-23 2018-11-09 泰尔茂株式会社 Foley's tube and its manufacturing method and method of disposal
US11129710B2 (en) 2011-12-09 2021-09-28 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US20160287708A9 (en) * 2000-03-15 2016-10-06 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US20050271701A1 (en) * 2000-03-15 2005-12-08 Orbus Medical Technologies, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) * 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) * 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
ATE495769T1 (en) * 2002-07-12 2011-02-15 Cook Inc COATED MEDICAL DEVICE
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US7349971B2 (en) * 2004-02-05 2008-03-25 Scenera Technologies, Llc System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information
JP2008500142A (en) * 2004-05-21 2008-01-10 メドトロニック ヴァスキュラー インコーポレイテッド Folding balloon for catheter
JP2008529652A (en) * 2005-02-15 2008-08-07 スティヒティング フォール デ テヘニッヘ ウェテンスハペン DNA-based coating for implants
US20070032703A1 (en) * 2005-07-11 2007-02-08 Sankaran Meera L Radially expansive surgical instruments for tissue retraction and methods for using the same
WO2007090385A2 (en) * 2006-02-09 2007-08-16 B.Braun Melsungen Ag Coating method for a folded balloon
US8609016B2 (en) * 2006-08-28 2013-12-17 Boston Scientific Scimed, Inc. Refoldable balloon and method of making and using the same
US8323325B2 (en) * 2006-09-25 2012-12-04 Boston Scientific Scimed, Inc. Balloon with wings for rotational stent
US8088100B2 (en) 2006-10-20 2012-01-03 Boston Scientific Scimed, Inc. Reinforced rewrappable balloon
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en) * 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) * 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
KR20120106880A (en) 2007-01-21 2012-09-26 헤모텍 아게 Medical product for treating stenosis of body passages and for preventing threatening restenosis
DE102007003184A1 (en) * 2007-01-22 2008-07-24 Orlowski, Michael, Dr. Method for loading structured surfaces
US7896840B2 (en) * 2007-04-05 2011-03-01 Boston Scientific Scimed, Inc. Catheter having internal mechanisms to encourage balloon re-folding
JP2008305262A (en) * 2007-06-08 2008-12-18 Konica Minolta Business Technologies Inc Printer introduction method in server and thin client environment
EP2170230A1 (en) * 2007-06-21 2010-04-07 Cappella Inc. Medical device delivery system with sheath having balloon-relative position
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US8066757B2 (en) * 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
US20100022951A1 (en) * 2008-05-19 2010-01-28 Luce, Forward, Hamilton 7 Scripps, Llp Detachable hub/luer device and processes
US8545514B2 (en) * 2008-04-11 2013-10-01 Covidien Lp Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby
US20100174309A1 (en) * 2008-05-19 2010-07-08 Mindframe, Inc. Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter
US9198687B2 (en) * 2007-10-17 2015-12-01 Covidien Lp Acute stroke revascularization/recanalization systems processes and products thereby
US10123803B2 (en) 2007-10-17 2018-11-13 Covidien Lp Methods of managing neurovascular obstructions
US8926680B2 (en) * 2007-11-12 2015-01-06 Covidien Lp Aneurysm neck bridging processes with revascularization systems methods and products thereby
US8585713B2 (en) 2007-10-17 2013-11-19 Covidien Lp Expandable tip assembly for thrombus management
US20100256600A1 (en) * 2009-04-04 2010-10-07 Ferrera David A Neurovascular otw pta balloon catheter and delivery system
US11337714B2 (en) 2007-10-17 2022-05-24 Covidien Lp Restoring blood flow and clot removal during acute ischemic stroke
US8088140B2 (en) 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
US9220522B2 (en) * 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
WO2009061969A2 (en) * 2007-11-06 2009-05-14 Daniel Gelbart In vivo inflatable structures, for example to expand stents
WO2009089297A2 (en) * 2008-01-07 2009-07-16 Intersect Partners, Llc Novel enhanced ptna rapid exchange type of catheter system
DE102008008926A1 (en) * 2008-02-13 2009-08-20 Biotronik Vi Patent Ag System for introducing an intraluminal endoprosthesis and method of making such a system
DE102008008925A1 (en) 2008-02-13 2009-08-20 Biotronik Vi Patent Ag Catheter, intraluminal endoprosthesis delivery system, and method of making the same
ES2647310T3 (en) 2008-02-22 2017-12-20 Covidien Lp Device for flow restoration
WO2009135125A2 (en) 2008-05-01 2009-11-05 Bayer Schering Pharma Ag Catheter balloon drug adherence techniques and methods
US8758422B2 (en) * 2008-06-11 2014-06-24 Boston Scientific Scimed, Inc. Edge protection via tapered balloon wrap
WO2010024898A2 (en) 2008-08-29 2010-03-04 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
EP2243501A1 (en) 2009-04-24 2010-10-27 Eurocor Gmbh Shellac and paclitaxel coated catheter balloons
DE202009006632U1 (en) 2009-05-07 2009-07-16 Sellin, Lothar Coating of medical surfaces
WO2011005421A2 (en) 2009-07-10 2011-01-13 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en) * 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
BR112012006925A2 (en) 2009-10-16 2016-06-07 Hemoteq Ag use of a composition containing at least one solvent, at least one pharmacological agent and a transport mediator or a mixture of transport mediators, method for coating balloon catheters and balloon catheters
US20110160645A1 (en) * 2009-12-31 2011-06-30 Boston Scientific Scimed, Inc. Cryo Activated Drug Delivery and Cutting Balloons
DE102010022588A1 (en) 2010-05-27 2011-12-01 Hemoteq Ag Balloon catheter with a particle-free drug-releasing coating
WO2012031236A1 (en) 2010-09-02 2012-03-08 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
DE102011100122A1 (en) 2011-04-26 2012-10-31 Eurocor Gmbh Catheter balloon coated with rapamycin and shellac
WO2013007273A1 (en) 2011-07-08 2013-01-17 Cardionovum Sp.Z.O.O. Balloon surface coating
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
WO2014008875A1 (en) 2012-07-12 2014-01-16 Cardionovum Gmbh Catheter balloon, method for producing a coated catheter balloon and use of the pharmacological active ingredient
US8827953B2 (en) 2013-01-15 2014-09-09 Krishna Rocha-Singh Apparatus and method for delivering intraluminal therapy
IE20130079A1 (en) 2013-02-13 2014-09-10 Patrick T Prendergast Method for loading dilatable catheter balloons and dilatation catheters obtained therefrom
JPWO2014162499A1 (en) * 2013-04-02 2017-02-16 テルモ株式会社 Implant assembly
WO2014177221A1 (en) 2013-05-02 2014-11-06 Cardionovum Gmbh Balloon surface coating
US11878497B2 (en) 2021-07-09 2024-01-23 The Procter & Gamble Company Methods and apparatuses for assembling elastic laminates with a rotating roll and removable layer

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087246A (en) * 1988-12-29 1992-02-11 C. R. Bard, Inc. Dilation catheter with fluted balloon
US5116318A (en) * 1989-06-06 1992-05-26 Cordis Corporation Dilatation balloon within an elastic sleeve
US5147302A (en) * 1989-04-21 1992-09-15 Scimed Life Systems, Inc. Method of shaping a balloon of a balloon catheter
US5209799A (en) * 1992-04-17 1993-05-11 Inverventional Technologies, Inc. Method for manufacturing a folding balloon catheter
US5290306A (en) * 1989-11-29 1994-03-01 Cordis Corporation Puncture resistant balloon catheter
US5350361A (en) * 1993-11-10 1994-09-27 Medtronic, Inc. Tri-fold balloon for dilatation catheter and related method
US5352236A (en) * 1992-09-29 1994-10-04 Medtronic, Inc. Balloon protector
US5409495A (en) * 1993-08-24 1995-04-25 Advanced Cardiovascular Systems, Inc. Apparatus for uniformly implanting a stent
US5456666A (en) * 1994-04-26 1995-10-10 Boston Scientific Corp Medical balloon folding into predetermined shapes and method
US5690670A (en) * 1989-12-21 1997-11-25 Davidson; James A. Stents of enhanced biocompatibility and hemocompatibility
US5718684A (en) * 1996-05-24 1998-02-17 Gupta; Mukesh Multi-lobed balloon catheter
US5792172A (en) * 1996-12-23 1998-08-11 Isostent, Inc. Multifold balloon for stent deployment
US6007545A (en) * 1997-09-12 1999-12-28 Invatec S.R.L. Dilating catheter for the introduction of expandable stents
US6033380A (en) * 1998-02-13 2000-03-07 Cordis Corporation Six-pleated catheter balloon and device for forming same
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6159229A (en) * 1994-10-19 2000-12-12 Medtronic Ave, Inc. Stent delivery and deployment method
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6296655B1 (en) * 1998-04-27 2001-10-02 Advanced Cardiovascular Systems, Inc. Catheter balloon with biased multiple wings

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3973703A (en) * 1973-06-05 1976-08-10 I.P.T. - Institute For Powder Technology Device for discharging powdery or granular material
US4100984A (en) * 1976-07-02 1978-07-18 Triangle Package Machinery Co. Net weigher with built-in checkweigher
US5807364A (en) * 1992-08-17 1998-09-15 Weyerhaeuser Company Binder treated fibrous webs and products
JP3548913B2 (en) * 1993-12-28 2004-08-04 ボストン サイエンティフィック コーポレーション Slip layered balloon and method for producing the same
JP2000217924A (en) * 1999-02-01 2000-08-08 Kanegafuchi Chem Ind Co Ltd Extended body for extended catheter and its manufacture
JP2001238964A (en) * 2000-02-29 2001-09-04 Japan Lifeline Co Ltd Stent
US6832905B2 (en) * 2002-01-16 2004-12-21 Paragon Trade Brands, Inc. System and method for dry forming absorbent cores

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087246A (en) * 1988-12-29 1992-02-11 C. R. Bard, Inc. Dilation catheter with fluted balloon
US5147302A (en) * 1989-04-21 1992-09-15 Scimed Life Systems, Inc. Method of shaping a balloon of a balloon catheter
US5342307A (en) * 1989-04-21 1994-08-30 Scimed Life Systems, Inc. Dilatation catheter with tri-fold balloon
US5116318A (en) * 1989-06-06 1992-05-26 Cordis Corporation Dilatation balloon within an elastic sleeve
US5290306A (en) * 1989-11-29 1994-03-01 Cordis Corporation Puncture resistant balloon catheter
US5690670A (en) * 1989-12-21 1997-11-25 Davidson; James A. Stents of enhanced biocompatibility and hemocompatibility
US5209799A (en) * 1992-04-17 1993-05-11 Inverventional Technologies, Inc. Method for manufacturing a folding balloon catheter
US5352236A (en) * 1992-09-29 1994-10-04 Medtronic, Inc. Balloon protector
US5409495A (en) * 1993-08-24 1995-04-25 Advanced Cardiovascular Systems, Inc. Apparatus for uniformly implanting a stent
US5350361A (en) * 1993-11-10 1994-09-27 Medtronic, Inc. Tri-fold balloon for dilatation catheter and related method
US5456666A (en) * 1994-04-26 1995-10-10 Boston Scientific Corp Medical balloon folding into predetermined shapes and method
US6159229A (en) * 1994-10-19 2000-12-12 Medtronic Ave, Inc. Stent delivery and deployment method
US5718684A (en) * 1996-05-24 1998-02-17 Gupta; Mukesh Multi-lobed balloon catheter
US5792172A (en) * 1996-12-23 1998-08-11 Isostent, Inc. Multifold balloon for stent deployment
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6007545A (en) * 1997-09-12 1999-12-28 Invatec S.R.L. Dilating catheter for the introduction of expandable stents
US6033380A (en) * 1998-02-13 2000-03-07 Cordis Corporation Six-pleated catheter balloon and device for forming same
US6296655B1 (en) * 1998-04-27 2001-10-02 Advanced Cardiovascular Systems, Inc. Catheter balloon with biased multiple wings
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11129710B2 (en) 2011-12-09 2021-09-28 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US11207175B2 (en) * 2011-12-09 2021-12-28 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US11666434B2 (en) 2011-12-09 2023-06-06 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US11690710B2 (en) 2011-12-09 2023-07-04 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
CN108778392A (en) * 2016-03-23 2018-11-09 泰尔茂株式会社 Foley's tube and its manufacturing method and method of disposal

Also Published As

Publication number Publication date
WO2003057073A2 (en) 2003-07-17
JP4663236B2 (en) 2011-04-06
MXPA04006570A (en) 2004-10-04
US20030130717A1 (en) 2003-07-10
EP1738791B1 (en) 2007-11-14
EP1461111B1 (en) 2006-12-27
DE60217176T2 (en) 2007-10-04
EP1461111A1 (en) 2004-09-29
DE60223611D1 (en) 2007-12-27
US7160317B2 (en) 2007-01-09
AU2002352718A1 (en) 2003-07-30
AU2003202889A1 (en) 2003-07-24
WO2003057073A3 (en) 2005-12-15
EP1738791A1 (en) 2007-01-03
JP2005514178A (en) 2005-05-19
WO2003059430A1 (en) 2003-07-24
DE60223611T2 (en) 2008-03-06
DE60217176D1 (en) 2007-02-08
CA2470416A1 (en) 2003-07-17
CA2472451A1 (en) 2003-07-24

Similar Documents

Publication Publication Date Title
US7160317B2 (en) Multiple-wing balloon catheter to reduce damage to coated expandable medical implants
US7070613B2 (en) Non-compliant balloon with compliant top-layer to protect coated stents during expansion
EP1395304B1 (en) Method and system for delivery of coated implants
US7482034B2 (en) Expandable mask stent coating method
US7435256B2 (en) Method and apparatus for controlled delivery of active substance
US6805703B2 (en) Protective membrane for reconfiguring a workpiece
US7938799B2 (en) Medical device for vessel compatibility during high pressure infusion
EP2173400B1 (en) Implantable medical devices having adjustable pore volume and methods for making the same
US6939318B2 (en) Method, tool, and system for deploying an implant into the body
EP1523289B1 (en) Stent coating holder

Legal Events

Date Code Title Description
AS Assignment

Owner name: SCIMED LIFE SYSTEMS, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MCHALE, TOM;WEBER, JAN;O'CONNOR, TIMOTHY;SIGNING DATES FROM 20011016 TO 20011023;REEL/FRAME:024653/0765

Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA

Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:024653/0861

Effective date: 20041222

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION