US20070191940A1 - Prosthesis for annuloplasty comprising a perforated element - Google Patents
Prosthesis for annuloplasty comprising a perforated element Download PDFInfo
- Publication number
- US20070191940A1 US20070191940A1 US11/737,474 US73747407A US2007191940A1 US 20070191940 A1 US20070191940 A1 US 20070191940A1 US 73747407 A US73747407 A US 73747407A US 2007191940 A1 US2007191940 A1 US 2007191940A1
- Authority
- US
- United States
- Prior art keywords
- prosthesis
- apertures
- ring element
- forming
- annuloplasty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
- A61F2/2448—D-shaped rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
Definitions
- the present invention relates in general to a device for cardiac valve repair operations and, in particular, to a prosthesis for annuloplasty.
- the human heart has four cardiac valves: the mitral valve, the tricuspid valve, the pulmonary valve and the aortic valve.
- the mitral valve is situated in the left atrio-ventricular ostium and regulates the unidirectionally of the flow of blood from the atrium to the ventricle. It opens in the diastole and closes in the systole, preventing blood from flowing back from the ventricle to the atrium.
- the annulus of a normally functioning mitral valve is characterized by shape, dimensions and flexibility such as to allow a correct closure of the valve lips during the systolic phase.
- the mitral annulus has a characteristic “kidney” shape (of “D” shape), and is more flexible in the portion corresponding to the posteria lip of the valve. Illnesses or genetic defects can cause deformations or dilatations of the annulus of the mitral valve, resulting in an incomplete closure thereof with consequent regurgitation of blood. The same phenomena can occur in the tricuspid valve, situated between the right atrium and right ventricle.
- Annuloplasty comprises surgically implanting a supporting prosthesis on the dilated or deformed annulus for the purpose of reinstating its dimensions and/or physiological shape in such a way as to allow the cardiac valve to function correctly.
- annuloplasty prostheses utilized in valve repair operations are called annuloplasty prostheses.
- Such prostheses are constituted by a closed or open ring structure comprising an inner core and an outer cladding of biocompatible material which allows surgical suture.
- Annuloplasty prostheses of various types have been described in the prior art. Initially, the prostheses proposed were predominantly of the rigid type for the purpose of drastically reducing the dilatation of the valve annulus. Such prostheses are generally constituted by a metal core (for example, a titanium alloy), an optional sheath of cladding around the core, and an outer cladding of textile for suturing. Rigid annuloplasty prostheses are described, for example, in U.S. Pat. No. 4,055,861 by Carpentier et al., issued Nov. 1, 1977, and U.S. Pat. No. 3,656,185 by Carpentier et al., issued Apr. 18, 1972.
- Rigid prostheses although satisfactory as far as reinstatement of the shape and dimensions of the valve annulus are concerned, do not allow the annulus of the valve to flex along the base of the posterior cuspid in such a way as to assist the cardiac muscle movements. Consequently, significant stress is imposed on the suture points subjected to torsion and traction, which prevents natural behavior of the valve.
- Semi-rigid prostheses seek to unite the advantages of the rigid type with those of the completely flexible type while avoiding the disadvantages of each.
- Semi-rigid annuloplasty prostheses are described, for example, in U.S. Pat. No. 5,061,277 by Carpentier et al., issued Oct. 29, 1991, U.S. Pat. No. 5,104,407 by Lam et al., issued Apr. 14, 1992, U.S. Pat. No. 5,674,279 by Wright et al., issued Oct. 7, 1997, U.S. Pat. No. 5,824,066 by Gross et al., issued Oct. 20, 1998, U.S. Pat. No. 5,607,471 by Seguin et al., issued Mar. 4, 1997, and U.S. Pat. No. 6,143,024 by Campbell et al., issued Nov. 7, 2000.
- the present invention provides a prosthesis for annuloplasty, the rigidity of which can be made variable in a described manner in dependence on the point, direction and mode (traction, compression, flexion, torsion) of application of the stresses.
- a prosthesis for annuloplasty comprising a laminar or tubular element having a plurality of apertures in at least one portion.
- This element can then be defined hereinafter in the present description as “perforated.”
- the apertures can be formed substantially according to any arrangement and with any shape and dimensions, so as to obtain the desired rigidity variation.
- a prosthesis provided with such a perforated element can have markedly different rigidity whilst having a constant transverse section, so as to satisfy possible requirements of uniformity of dimensions.
- the prostheses of the invention have the additional advantage of an easier suturability since the apertures formed in the perforated element can constitute, if necessary, preferential transit ways for the passage of a suture needle.
- FIG. 1 is a plan view, partially in section, of a prosthesis of the invention of closed ring type (or “closed loop type”).
- FIG. 2 is a prospective view, on an enlarged scale, of a tubular element forming part of the prosthesis of FIG. 1 .
- FIGS. 3 to 6 are perspective views of respective alternative embodiments of the tubular element of FIG. 2 .
- FIG. 7 is a plan view, partially in section, of a further alternative open ring type (or “open loop type”) embodiment of the prosthesis of the invention.
- the reference 10 indicates in FIG. 1 a prosthesis for annuloplasty.
- the shape of this prosthesis generally reproduces the geometry of the annulus of a mitral valve.
- This prosthesis has a closed ring shaped in the form of a D with an approximately rectilinear intertrigonal section 12 and a curved section 14 .
- the prosthesis 10 is externally clad, in a manner known per se by a sheath 16 of biocompatible material.
- the sheath is made from materials chosen from the group consisting of polymers, synthetic textiles, biological tissues and their combinations.
- the sheath 16 covers a tubular ring element 18 having a transverse section of constant circular shape over its entire extent.
- the element 18 has in its wall ( FIG.
- the surface of the tubular element 18 and/or of the sheath 16 can be clad partially or totally with a thin layer of hemocompatible carbon, for example turbostratic carbon.
- a thin layer of hemocompatible carbon for example turbostratic carbon.
- the procedure for the production of such a cladding is, for example, described in U.S. Pat. Nos. 5,084,151, 5,387,247, 5,370,684, 5,133,845 and 5,423,886, the contents of each of which are hereby incorporated herein by reference.
- This cladding contributes to an improved hemocompatibility of the prosthesis 10 and to a controlled tissue growth of the receiving organism.
- FIG. 3 illustrates an alternative embodiment of the tubular element 18 , which has, in addition to the apertures illustrated in the preceding FIG., further apertures 20 disposed along two lines parallel to the longitudinal axis 22 of the element 18 and diametrically opposite across the axis 18 so as to have a substantially transverse spatial orientation with respect to the general plane of the prosthesis 10 .
- the presence of apertures 20 in the arrangement just described influences the rigidity characteristics of the prosthesis 10 under the action of stresses which act both in the general plane and transversely with respect to it.
- the prosthesis can be rendered, for example, less rigid against stresses which act in its general plane along an antero-posterior direction (that is to say in a direction distinguished by the reference numeral 24 in FIG.
- the desired characteristics of variation in flexibility can also be obtained with a suitable variation of the dimensions of the apertures 20 of the element 18 , as illustrated for example in FIG. 4 .
- FIG. 5 illustrates a further embodiment of the tubular element 18 , in which the apertures 20 are formed in the shape of rings interrupted along a generatrix by a bridge 26 connecting adjacent portions 28 , also of annular shape, of the tubular element 18 .
- Such apertures 20 can be characterized by their extent (a) in the axial direction, the extent (b) in the axial direction of the tubular portions 28 interposed between two adjacent apertures 20 , and the extent (c) of the bridges 26 in the circumferential direction.
- the values of (a), (b), and (c) can be selected independently at will and maintained constant or made to vary along the axial extent of the element 18 so as to determine the rigidity of the prosthesis 10 in a desired manner in dependence on the point and direction of application of the stresses.
- FIG. 6 illustrates a further embodiment of the tubular element 18 , in which the apertures 20 have a sinuous shape limited in one or more portions by edges 30 in contact, or almost in contact, in the absence of external stresses.
- a prosthesis provided with a perforated tubular element 18 of this type opposes enlargement of the apertures 20 with a predetermined force in response to a traction stress, allowing the prosthesis to extend in the axial direction, whilst further closure of the apertures 20 in response to a compression stress is in fact prevented by the contacting edges 30 , so that the behavior of the prosthesis is similar in this case to that of a rigid body.
- Such a prosthesis thus has differentiated rigidity in response to stresses acting in the axial direction, being rather rigid in response to compression stresses but on the other hand deformable in response to traction stresses acting in the opposite sense along the same direction.
- Such behavior is particularly convenient for encouraging, on the one hand, the natural dilatation of the annulus in the diastolic phase and, on the other hand, to guarantee the absence of compression and corrugation phenomena (pleating) following surgical suture during a valve repair operation.
- FIG. 7 illustrates a further embodiment of the prosthesis of the invention having an open ring shape and having a perforated element 18 of laminar or tubular structure.
- the shape, dimensions and/or spacing of the apertures 20 it is possible to obtain the desired variations in rigidity.
Abstract
A prosthesis for annuloplasty comprising a laminar or tubular element having a plurality of apertures along at least one portion. Preferably, the shape, dimensions, and arrangements of the apertures in this prosthesis are chosen in such a way as to give the prosthesis a differentiated flexibility in dependence on the location and direction of application of an external stress.
Description
- The present application is a continuation of U.S. patent application Ser. No. 10/393,448, entitled “PROSTHESIS FOR ANNULOPLASTY COMPRISING A PERFORATED ELEMENT” filed Mar. 20, 2003 by Pietro Arru et al., which claims the benefit of European Patent Application No. 02425190.2 filed Mar. 27, 2002. Each of the foregoing U.S. and European patent applications is incorporated herein by reference in its entirety. Any disclaimer of claim scope that may have occurred during the prosecution of the above-referenced application(s) is hereby expressly rescinded.
- The present invention relates in general to a device for cardiac valve repair operations and, in particular, to a prosthesis for annuloplasty.
- The human heart has four cardiac valves: the mitral valve, the tricuspid valve, the pulmonary valve and the aortic valve. The mitral valve is situated in the left atrio-ventricular ostium and regulates the unidirectionally of the flow of blood from the atrium to the ventricle. It opens in the diastole and closes in the systole, preventing blood from flowing back from the ventricle to the atrium. The annulus of a normally functioning mitral valve is characterized by shape, dimensions and flexibility such as to allow a correct closure of the valve lips during the systolic phase. For example, the mitral annulus has a characteristic “kidney” shape (of “D” shape), and is more flexible in the portion corresponding to the posteria lip of the valve. Illnesses or genetic defects can cause deformations or dilatations of the annulus of the mitral valve, resulting in an incomplete closure thereof with consequent regurgitation of blood. The same phenomena can occur in the tricuspid valve, situated between the right atrium and right ventricle.
- A frequently used method for eliminating some pathological alterations of the mitral and tricuspid valves is that of reinstating the correct shape and dimensions of the valve annulus by means of surgical procedures known as annuloplasty. Annuloplasty comprises surgically implanting a supporting prosthesis on the dilated or deformed annulus for the purpose of reinstating its dimensions and/or physiological shape in such a way as to allow the cardiac valve to function correctly.
- Support prostheses utilized in valve repair operations are called annuloplasty prostheses. In the majority of cases such prostheses are constituted by a closed or open ring structure comprising an inner core and an outer cladding of biocompatible material which allows surgical suture.
- Annuloplasty prostheses of various types have been described in the prior art. Initially, the prostheses proposed were predominantly of the rigid type for the purpose of drastically reducing the dilatation of the valve annulus. Such prostheses are generally constituted by a metal core (for example, a titanium alloy), an optional sheath of cladding around the core, and an outer cladding of textile for suturing. Rigid annuloplasty prostheses are described, for example, in U.S. Pat. No. 4,055,861 by Carpentier et al., issued Nov. 1, 1977, and U.S. Pat. No. 3,656,185 by Carpentier et al., issued Apr. 18, 1972.
- Rigid prostheses, although satisfactory as far as reinstatement of the shape and dimensions of the valve annulus are concerned, do not allow the annulus of the valve to flex along the base of the posterior cuspid in such a way as to assist the cardiac muscle movements. Consequently, significant stress is imposed on the suture points subjected to torsion and traction, which prevents natural behavior of the valve.
- Subsequently, semi-rigid or completely flexible prosthesis models were proposed. Completely flexible annuloplasty prostheses are described, for example, in U.S. Pat. No. 5,041,130 by Carpentier et al., issued Aug. 20, 1991, U.S. Pat. No. 5,716,397 by Myers et al. issued Feb. 10, 1998, U.S. Pat. No. 6,102,945 by Campbell et al., issued Aug. 15, 2000, and U.S. Pat. No. 5,064,431 by Gilbertson et al., issued Nov. 12, 1991. The completely flexible prostheses follow the movements of the annulus during the cardiac cycle in an optimal manner. However, they have the disadvantage of not allowing the shape to be reconstructed in an optimal manner.
- Semi-rigid prostheses seek to unite the advantages of the rigid type with those of the completely flexible type while avoiding the disadvantages of each. Semi-rigid annuloplasty prostheses are described, for example, in U.S. Pat. No. 5,061,277 by Carpentier et al., issued Oct. 29, 1991, U.S. Pat. No. 5,104,407 by Lam et al., issued Apr. 14, 1992, U.S. Pat. No. 5,674,279 by Wright et al., issued Oct. 7, 1997, U.S. Pat. No. 5,824,066 by Gross et al., issued Oct. 20, 1998, U.S. Pat. No. 5,607,471 by Seguin et al., issued Mar. 4, 1997, and U.S. Pat. No. 6,143,024 by Campbell et al., issued Nov. 7, 2000.
- In particular, U.S. Pat. No. 5,104,407 describes a ring prosthesis comprising an annular support element which is substantially more rigid in one part than in the remainder. This more rigid part projects transversely with respect to the general plane in which the remaining part of the support element lies. On the other hand, U.S. Pat. No. 5,607,471 describes a ring prosthesis having variable transverse sections, and therefore differentiated rigidity along its circumferential extent.
- All these known prostheses have, however, limitations in relation to the possibility of exhibiting a variable rigidity in dependence on the point and/or mode of application of the stresses. For example, U.S. Pat. No. 5,104,407 provides a structure with variable rigidity in the plane of the ring, but with a limited possibility of flexure outside this plane. On the other hand, U.S. Pat. No. 5,607,471 describes technical arrangements able to guarantee an improved flexibility out of the plane of the annulus. However, the possibility of effectively obtaining characteristics of variable rigidity of the prosthesis, for example, in its localised portions as well, appears significantly limited by the necessity to vary the area of the entire resistant section of the internal element. Moreover, the technical arrangements described in U.S. Pat. No. 5,607,471 do not allow an optimal behavior of the prosthesis in response to stresses in a tangential direction to be obtained (that is to say stresses directed along its longitudinal axis, which is usually closed in a ring), the rigidity in response to traction and compression at the same point of the internal element being substantially undifferentiated.
- The present invention provides a prosthesis for annuloplasty, the rigidity of which can be made variable in a described manner in dependence on the point, direction and mode (traction, compression, flexion, torsion) of application of the stresses. According to the invention, this is achieved thanks to a prosthesis for annuloplasty comprising a laminar or tubular element having a plurality of apertures in at least one portion. This element can then be defined hereinafter in the present description as “perforated.” In the perforated element, the apertures can be formed substantially according to any arrangement and with any shape and dimensions, so as to obtain the desired rigidity variation. For example, a prosthesis provided with such a perforated element can have markedly different rigidity whilst having a constant transverse section, so as to satisfy possible requirements of uniformity of dimensions.
- The perforated element can be formed in its laminar form both with a flat development and with various three-dimensional shapes. Preferably, however, the perforated element is made in a tubular shape because this shape allows a more flexible and efficient arrangement of the apertures for the purpose of influencing the properties of rigidity of prosthesis. As a matter of fact, the transverse section of the perforated tubular element can be of any shape. A circular transverse section is preferred for reasons of practicality and simplicity of production.
- The prostheses of the invention have the additional advantage of an easier suturability since the apertures formed in the perforated element can constitute, if necessary, preferential transit ways for the passage of a suture needle.
- There are no particular limitations in relation to the material usable for the production of the perforated element. The perforated element can be produced in metal, polymeric, or composite material. For their part, the apertures can be formed in the perforated element with any conventional technology. For example, if the perforated element is made of metal, the apertures can be formed by piercing a pre-formed tube by a laser, electroerosion, or cutting. If the perforated element were formed of polymeric material, it could be directly formed into its definitive shape by moulding technologies. Overall, therefore, the production of the prosthesis of the invention is simple and economical.
- Further advantages and characteristics of the invention will become apparent from the following detailed description provided purely by way of non-limitative example, with reference to the attached drawings.
-
FIG. 1 is a plan view, partially in section, of a prosthesis of the invention of closed ring type (or “closed loop type”). -
FIG. 2 is a prospective view, on an enlarged scale, of a tubular element forming part of the prosthesis ofFIG. 1 . - FIGS. 3 to 6 are perspective views of respective alternative embodiments of the tubular element of
FIG. 2 . -
FIG. 7 is a plan view, partially in section, of a further alternative open ring type (or “open loop type”) embodiment of the prosthesis of the invention. - The
reference 10 indicates inFIG. 1 a prosthesis for annuloplasty. The shape of this prosthesis generally reproduces the geometry of the annulus of a mitral valve. This prosthesis has a closed ring shaped in the form of a D with an approximatelyrectilinear intertrigonal section 12 and acurved section 14. Theprosthesis 10 is externally clad, in a manner known per se by asheath 16 of biocompatible material. Preferably the sheath is made from materials chosen from the group consisting of polymers, synthetic textiles, biological tissues and their combinations. Thesheath 16 covers atubular ring element 18 having a transverse section of constant circular shape over its entire extent. Theelement 18 has in its wall (FIG. 2 ) a plurality ofcircular apertures 20 spaced along two lines parallel to thelongitudinal axis 22 of theelement 18 and diametrically opposite one another across theaxis 22 in such a way that theapertures 20 have a spatial orientation substantially parallel to the general plane of theprosthesis 10. Preferably, there are no such apertures in theintertrigonal section 12, which must be more rigid, whilst they gradually become more closely spaced towards the central part of thecurved section 14, which must be more flexible. The internal cavity of theelement 18 may possibly be filled, partially or totally, withelastomeric material 23, in particular silicone, polyurethane and their mixtures, as for example described in U.S. Pat. No. 10/164,358, filed Jun. 5, 2002, the contents of which are hereby incorporated herein by reference. - The surface of the
tubular element 18 and/or of thesheath 16 can be clad partially or totally with a thin layer of hemocompatible carbon, for example turbostratic carbon. The procedure for the production of such a cladding is, for example, described in U.S. Pat. Nos. 5,084,151, 5,387,247, 5,370,684, 5,133,845 and 5,423,886, the contents of each of which are hereby incorporated herein by reference. This cladding contributes to an improved hemocompatibility of theprosthesis 10 and to a controlled tissue growth of the receiving organism. -
FIG. 3 illustrates an alternative embodiment of thetubular element 18, which has, in addition to the apertures illustrated in the preceding FIG.,further apertures 20 disposed along two lines parallel to thelongitudinal axis 22 of theelement 18 and diametrically opposite across theaxis 18 so as to have a substantially transverse spatial orientation with respect to the general plane of theprosthesis 10. The presence ofapertures 20 in the arrangement just described influences the rigidity characteristics of theprosthesis 10 under the action of stresses which act both in the general plane and transversely with respect to it. In particular, the prosthesis can be rendered, for example, less rigid against stresses which act in its general plane along an antero-posterior direction (that is to say in a direction distinguished by thereference numeral 24 inFIG. 1 ), with respect to stresses which act in the general plane along a direction orthogonal to the antero-posterior direction. As far as the rigidity characteristics against stresses which act transversely with respect to the general plane of theprostheses 10 are concerned, they are for example chosen in such a way as to facilitate the assumption of a saddle shape in certain phases of the cardiac cycle. - The desired characteristics of variation in flexibility can also be obtained with a suitable variation of the dimensions of the
apertures 20 of theelement 18, as illustrated for example inFIG. 4 . -
FIG. 5 illustrates a further embodiment of thetubular element 18, in which theapertures 20 are formed in the shape of rings interrupted along a generatrix by abridge 26 connectingadjacent portions 28, also of annular shape, of thetubular element 18.Such apertures 20 can be characterized by their extent (a) in the axial direction, the extent (b) in the axial direction of thetubular portions 28 interposed between twoadjacent apertures 20, and the extent (c) of thebridges 26 in the circumferential direction. The values of (a), (b), and (c) can be selected independently at will and maintained constant or made to vary along the axial extent of theelement 18 so as to determine the rigidity of theprosthesis 10 in a desired manner in dependence on the point and direction of application of the stresses. -
FIG. 6 illustrates a further embodiment of thetubular element 18, in which theapertures 20 have a sinuous shape limited in one or more portions byedges 30 in contact, or almost in contact, in the absence of external stresses. A prosthesis provided with a perforatedtubular element 18 of this type opposes enlargement of theapertures 20 with a predetermined force in response to a traction stress, allowing the prosthesis to extend in the axial direction, whilst further closure of theapertures 20 in response to a compression stress is in fact prevented by the contactingedges 30, so that the behavior of the prosthesis is similar in this case to that of a rigid body. Such a prosthesis thus has differentiated rigidity in response to stresses acting in the axial direction, being rather rigid in response to compression stresses but on the other hand deformable in response to traction stresses acting in the opposite sense along the same direction. Such behavior is particularly convenient for encouraging, on the one hand, the natural dilatation of the annulus in the diastolic phase and, on the other hand, to guarantee the absence of compression and corrugation phenomena (pleating) following surgical suture during a valve repair operation. - It goes without saying that the arrangements of the
apertures 20 previously illustrated and/or described can be combined in any way in different portions of the sameperforated element 18 so as to regulate the rigidity of theprosthesis 10 in a desired manner in dependence on the point and direction of application of the stresses. Equally it is also possible, in embodiments of theperforated element 18 not illustrated, to arrange the apertures in an irregular manner rather than in a regularly repeating pattern. -
FIG. 7 illustrates a further embodiment of the prosthesis of the invention having an open ring shape and having aperforated element 18 of laminar or tubular structure. In this case, too, by varying the shape, dimensions and/or spacing of theapertures 20 it is possible to obtain the desired variations in rigidity. - Naturally, the principle of the invention remaining the same, the details of construction and the embodiments can be widely varied with respect to what has been described purely by way of example, without by this departing from its ambit.
Claims (20)
1. An annuloplasty prosthesis for repair of a cardiac valve annulus by affecting the dimensions or shape of the valve annulus, so as to improve performance of the cardiac valve, the prosthesis comprising:
a ring element having a longitudinal axis, a curved portion, and a generally straight portion, the ring element configured to have a shape generally corresponding to a desired shape of a normal cardiac valve annulus; and
a sheath covering at least a portion of the ring element;
wherein the ring element defines a plurality of apertures each having a characteristic selected to effect the flexibility of the annuloplasty prosthesis.
2. The annuloplasty prosthesis of claim 1 wherein the characteristic includes one or more of a size, a shape, and a location along the longitudinal axis.
3. The annuloplasty prosthesis of claim 1 wherein the apertures are configured such that the curved portion is more flexible than at least the straight portion.
4. The annuloplasty prosthesis of claim 1 wherein the ring element is an open ring having a first end and a second end.
5. The annuloplasty prosthesis of claim 1 wherein the ring element has a tubular cross-section.
6. The annuloplasty prosthesis of claim 1 wherein the ring element has a laminar cross-section.
7. An annuloplasty prosthesis comprising a ring element having a size and a shape generally corresponding to a cardiac valve annulus, the ring element including a plurality of apertures for controlling the flexibility of the annuloplasty prosthesis.
8. The annuloplasty prosthesis of claim 7 wherein the apertures are disposed along at least a portion of the ring element and are configured such that the prosthesis has a desired non-uniform flexibility along its length.
9. The annuloplasty prosthesis of claim 7 wherein the apertures are configured such that the prosthesis has a differentiated flexibility depending on the location and direction of application of an external stress.
10. The annuloplasty prosthesis of claim 7 wherein the prosthesis is generally planar, and wherein the apertures are configured such that the prosthesis has a first flexibility in response to a first external stress acting in the general plane of the prosthesis and a second flexibility in response to a second external stress acting generally transverse to the general plane of the prosthesis.
11. The annuloplasty prosthesis of claim 7 wherein:
the ring element has a first portion and a second portion; and
at least one of a size, a shape, or a position of each aperture is selected such that the first portion is more flexible than at least a part of the second portion.
12. The annuloplasty prosthesis of claim 7 wherein the ring element has a curved portion and a straight portion, and wherein the apertures are configured such that the curved portion is more flexible than the straight portion.
13. The annuloplasty prosthesis of claim 12 wherein the curved portion includes first and second end regions and a center region therebetween, and wherein the apertures are configured such that the center region is more flexible than the first and second end regions.
14. The annuloplasty prosthesis of claim 7 wherein the ring element is an open ring having first and second ends.
15. A method of forming an annuloplasy prosthesis, the method comprising:
forming a plurality of apertures in a laminar or tubular element, including configuring the apertures such that the laminar or tubular element has a desired non-uniform flexibility along its length; and
forming the laminar or tubular element into a ring element having a shape generally corresponding to a shape of a natural cardiac valve annulus.
16. The method of claim 15 wherein forming the plurality of apertures includes selecting at least one of a size, a shape, and a location of each aperture such that the laminar or tubular element has a desired non-uniform flexibility along its length.
17. The method of claim 15 wherein forming the plurality of apertures includes configuring the apertures such that the prosthesis has a differentiated flexibility depending on the location and direction of application of an external stress.
18. The method of claim 15 wherein:
forming the laminar or tubular element into a ring element includes forming a generally planar ring element; and
forming the plurality of apertures includes configuring the apertures such that the annuloplasty prosthesis has a first flexibility in response to a first external stress acting in the general plane of the ring element and a second flexibility in response to a second external stress acting generally transverse to the general plane of the ring element.
19. The method of claim 15 wherein:
forming the laminar or tubular element includes forming the laminar or tubular element into a ring element having a curved portion and a generally straight portion; and
forming the plurality of apertures includes configuring the apertures such that the curved portion is more flexible than at least a part of the straight portion.
20. The method of claim 15 wherein forming the laminar or tubular element includes forming the laminar or tubular element into an open ring element having a center portion and first and second ends.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/737,474 US20070191940A1 (en) | 2002-03-27 | 2007-04-19 | Prosthesis for annuloplasty comprising a perforated element |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02425190A EP1348406B1 (en) | 2002-03-27 | 2002-03-27 | A prosthesis for annuloplasty comprising a perforated element |
EP02425190.2 | 2002-03-27 | ||
US10/393,448 US7220277B2 (en) | 2002-03-27 | 2003-03-20 | Prosthesis for annuloplasty comprising a perforated element |
US11/737,474 US20070191940A1 (en) | 2002-03-27 | 2007-04-19 | Prosthesis for annuloplasty comprising a perforated element |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/393,448 Continuation US7220277B2 (en) | 2002-03-27 | 2003-03-20 | Prosthesis for annuloplasty comprising a perforated element |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070191940A1 true US20070191940A1 (en) | 2007-08-16 |
Family
ID=27798967
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/393,448 Expired - Lifetime US7220277B2 (en) | 2002-03-27 | 2003-03-20 | Prosthesis for annuloplasty comprising a perforated element |
US11/737,474 Abandoned US20070191940A1 (en) | 2002-03-27 | 2007-04-19 | Prosthesis for annuloplasty comprising a perforated element |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/393,448 Expired - Lifetime US7220277B2 (en) | 2002-03-27 | 2003-03-20 | Prosthesis for annuloplasty comprising a perforated element |
Country Status (5)
Country | Link |
---|---|
US (2) | US7220277B2 (en) |
EP (2) | EP2153799B1 (en) |
AT (2) | ATE451080T1 (en) |
DE (1) | DE60234675D1 (en) |
ES (1) | ES2370585T3 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070162112A1 (en) * | 2005-12-28 | 2007-07-12 | Sorin Biomedica Cardio | Annuloplasty prosthesis with an auxetic structure |
US20080086203A1 (en) * | 2006-10-06 | 2008-04-10 | Roberts Harold G | Mitral and tricuspid annuloplasty rings |
US8529620B2 (en) | 2007-05-01 | 2013-09-10 | Ottavio Alfieri | Inwardly-bowed tricuspid annuloplasty ring |
US8932350B2 (en) | 2010-11-30 | 2015-01-13 | Edwards Lifesciences Corporation | Reduced dehiscence annuloplasty ring |
US8992606B2 (en) | 2010-03-19 | 2015-03-31 | Xavier Ruyra Baliarda | Prosthetic device for repairing a mitral valve |
US9155622B2 (en) | 2013-08-14 | 2015-10-13 | Sorin Group Italia S.R.L. | Apparatus and method for chordal replacement |
CN105407838A (en) * | 2013-06-05 | 2016-03-16 | Lc疗法有限公司 | Annuloplasty device |
CN107753152A (en) * | 2016-08-22 | 2018-03-06 | 北京市普惠生物医学工程有限公司 | Valve forming ring |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7883539B2 (en) | 1997-01-02 | 2011-02-08 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
CA2526347C (en) | 2003-05-20 | 2010-07-06 | The Cleveland Clinic Foundation | Apparatus and methods for repair of a cardiac valve |
US8349001B2 (en) * | 2004-04-07 | 2013-01-08 | Medtronic, Inc. | Pharmacological delivery implement for use with cardiac repair devices |
EP1913900A1 (en) * | 2004-06-29 | 2008-04-23 | SIEVERS, Hans-Hinrich, Dr. | Implant with a ring-shaped base plate |
US7758638B2 (en) | 2004-07-13 | 2010-07-20 | Ats Medical, Inc. | Implant with an annular base |
US8608797B2 (en) | 2005-03-17 | 2013-12-17 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
US20060259135A1 (en) * | 2005-04-20 | 2006-11-16 | The Cleveland Clinic Foundation | Apparatus and method for replacing a cardiac valve |
US20060247672A1 (en) * | 2005-04-27 | 2006-11-02 | Vidlund Robert M | Devices and methods for pericardial access |
ATE534346T1 (en) * | 2005-05-06 | 2011-12-15 | Sorin Biomedica Cardio Srl | ANNULOPLASTY PROSTHESIS |
US8951285B2 (en) | 2005-07-05 | 2015-02-10 | Mitralign, Inc. | Tissue anchor, anchoring system and methods of using the same |
US20070067027A1 (en) * | 2005-09-14 | 2007-03-22 | Micardia Corporation | Left atrial balloon catheter |
WO2007072399A1 (en) * | 2005-12-19 | 2007-06-28 | Robert William Mayo Frater | Annuloplasty prosthesis |
WO2008008889A2 (en) * | 2006-07-12 | 2008-01-17 | Tigran Khalapyan | Annuloplasty system and surgical method |
WO2010004546A1 (en) | 2008-06-16 | 2010-01-14 | Valtech Cardio, Ltd. | Annuloplasty devices and methods of delivery therefor |
US9974653B2 (en) | 2006-12-05 | 2018-05-22 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US8216303B2 (en) * | 2007-11-19 | 2012-07-10 | The Cleveland Clinic Foundation | Apparatus and method for treating a regurgitant heart valve |
US8784483B2 (en) | 2007-11-19 | 2014-07-22 | The Cleveland Clinic Foundation | Apparatus and method for treating a regurgitant heart valve |
DE102008012113A1 (en) | 2008-03-02 | 2009-09-03 | Transcatheter Technologies Gmbh | Implant e.g. heart-valve-carrying stent, for e.g. arresting blood vessel, has fiber by which section of implant is reducible according to increasing of implant at extended diameter by unfolding or expansion of diameter with expansion unit |
US8382829B1 (en) | 2008-03-10 | 2013-02-26 | Mitralign, Inc. | Method to reduce mitral regurgitation by cinching the commissure of the mitral valve |
US20100152844A1 (en) * | 2008-12-15 | 2010-06-17 | Couetil Jean-Paul A | Annuloplasty ring with directional flexibilities and rigidities to assist the mitral annulus dynamics |
US10517719B2 (en) | 2008-12-22 | 2019-12-31 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
US9011530B2 (en) | 2008-12-22 | 2015-04-21 | Valtech Cardio, Ltd. | Partially-adjustable annuloplasty structure |
US8545553B2 (en) | 2009-05-04 | 2013-10-01 | Valtech Cardio, Ltd. | Over-wire rotation tool |
US8715342B2 (en) | 2009-05-07 | 2014-05-06 | Valtech Cardio, Ltd. | Annuloplasty ring with intra-ring anchoring |
CN102341063B (en) | 2008-12-22 | 2015-11-25 | 瓦尔泰克卡迪欧有限公司 | Adjustable annuloplasty device and governor motion thereof |
US8241351B2 (en) | 2008-12-22 | 2012-08-14 | Valtech Cardio, Ltd. | Adjustable partial annuloplasty ring and mechanism therefor |
US8353956B2 (en) | 2009-02-17 | 2013-01-15 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
US9968452B2 (en) | 2009-05-04 | 2018-05-15 | Valtech Cardio, Ltd. | Annuloplasty ring delivery cathethers |
IT1396078B1 (en) * | 2009-10-16 | 2012-11-09 | Uni Degli Studi Del Piemonte Orientale Amedeo Avogadro | DEVICE FOR CORRECTION OF THE COMBINABLE MITRAL REGOLOR WITH A PROSTHESIS FOR ANULOPLASTICS, AND A KIT INCLUDING SUCH A DEVICE. |
US9180007B2 (en) | 2009-10-29 | 2015-11-10 | Valtech Cardio, Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
US10098737B2 (en) | 2009-10-29 | 2018-10-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
EP2506777B1 (en) | 2009-12-02 | 2020-11-25 | Valtech Cardio, Ltd. | Combination of spool assembly coupled to a helical anchor and delivery tool for implantation thereof |
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
CN107496054B (en) | 2011-06-21 | 2020-03-03 | 托尔福公司 | Prosthetic heart valve devices and related systems and methods |
US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
CN111000663B (en) | 2011-10-19 | 2022-04-15 | 托尔福公司 | Prosthetic heart valve devices, prosthetic mitral valves, and related systems and methods |
EP3943047B1 (en) | 2011-10-19 | 2023-08-30 | Twelve, Inc. | Device for heart valve replacement |
US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US8858623B2 (en) | 2011-11-04 | 2014-10-14 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
EP3970627B1 (en) | 2011-11-08 | 2023-12-20 | Edwards Lifesciences Innovation (Israel) Ltd. | Controlled steering functionality for implant-delivery tool |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
EP2900150B1 (en) | 2012-09-29 | 2018-04-18 | Mitralign, Inc. | Plication lock delivery system |
US9949828B2 (en) | 2012-10-23 | 2018-04-24 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
WO2014064695A2 (en) | 2012-10-23 | 2014-05-01 | Valtech Cardio, Ltd. | Percutaneous tissue anchor techniques |
US9730793B2 (en) | 2012-12-06 | 2017-08-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
EP2948103B1 (en) | 2013-01-24 | 2022-12-07 | Cardiovalve Ltd | Ventricularly-anchored prosthetic valves |
US9724084B2 (en) | 2013-02-26 | 2017-08-08 | Mitralign, Inc. | Devices and methods for percutaneous tricuspid valve repair |
US10449333B2 (en) | 2013-03-14 | 2019-10-22 | Valtech Cardio, Ltd. | Guidewire feeder |
EP2968847B1 (en) | 2013-03-15 | 2023-03-08 | Edwards Lifesciences Corporation | Translation catheter systems |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
FR3004335A1 (en) * | 2013-04-11 | 2014-10-17 | Cormove | PARTIALLY DEFORMABLE ANNULOPLASTY PROSTHESIS |
CN104010593B (en) * | 2013-07-29 | 2016-05-25 | 金仕生物科技(常熟)有限公司 | Artificial heart valve forming ring |
US10070857B2 (en) | 2013-08-31 | 2018-09-11 | Mitralign, Inc. | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
WO2015059699A2 (en) | 2013-10-23 | 2015-04-30 | Valtech Cardio, Ltd. | Anchor magazine |
US9610162B2 (en) | 2013-12-26 | 2017-04-04 | Valtech Cardio, Ltd. | Implantation of flexible implant |
CN103735337B (en) * | 2013-12-31 | 2016-08-17 | 金仕生物科技(常熟)有限公司 | Artificial heart valve forming ring |
ES2570077B1 (en) * | 2014-10-13 | 2017-03-03 | Jack KANOUZI BASCHOUR | Implantation prosthetic ring for the correction and prevention of breast areolar asymmetry |
EP3206629B1 (en) | 2014-10-14 | 2021-07-14 | Valtech Cardio, Ltd. | Apparatus for heart valve leaflet restraining |
EP3253333B1 (en) | 2015-02-05 | 2024-04-03 | Cardiovalve Ltd | Prosthetic valve with axially-sliding frames |
US20160256269A1 (en) | 2015-03-05 | 2016-09-08 | Mitralign, Inc. | Devices for treating paravalvular leakage and methods use thereof |
CN114515173A (en) | 2015-04-30 | 2022-05-20 | 瓦尔泰克卡迪欧有限公司 | Valvuloplasty techniques |
WO2017117370A2 (en) | 2015-12-30 | 2017-07-06 | Mitralign, Inc. | System and method for reducing tricuspid regurgitation |
US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
US10433952B2 (en) | 2016-01-29 | 2019-10-08 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
GB201611910D0 (en) | 2016-07-08 | 2016-08-24 | Valtech Cardio Ltd | Adjustable annuloplasty device with alternating peaks and troughs |
CN114587712A (en) | 2016-08-10 | 2022-06-07 | 卡迪尔维尔福股份有限公司 | Prosthetic valve with coaxial frame |
AU2017361296B2 (en) | 2016-11-21 | 2022-09-29 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
CN108618869B (en) * | 2017-03-17 | 2021-01-22 | 先健科技(深圳)有限公司 | Artificial heart valve forming ring |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
RU2666929C1 (en) * | 2017-06-21 | 2018-09-13 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) | Closed ring frame for annuloplasty of the mitral valve of the heart, method of its manufacture and application |
US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
CA3070111A1 (en) * | 2017-07-18 | 2019-01-24 | Kephalios S.A.S. | Adjustable percutaneous annuloplasty devices, delivery systems, a method for percutaneously deploying an annuloplasty device and a method performed by one or more processing devices |
US10856984B2 (en) | 2017-08-25 | 2020-12-08 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US10835221B2 (en) | 2017-11-02 | 2020-11-17 | Valtech Cardio, Ltd. | Implant-cinching devices and systems |
US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
WO2019145947A1 (en) | 2018-01-24 | 2019-08-01 | Valtech Cardio, Ltd. | Contraction of an annuloplasty structure |
EP3743014B1 (en) | 2018-01-26 | 2023-07-19 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
AU2019301967A1 (en) | 2018-07-12 | 2021-01-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty systems and locking tools therefor |
CA3118599A1 (en) | 2018-11-08 | 2020-05-14 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
US11602429B2 (en) | 2019-04-01 | 2023-03-14 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
AU2020271896B2 (en) | 2019-04-10 | 2022-10-13 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
US11452599B2 (en) | 2019-05-02 | 2022-09-27 | Twelve, Inc. | Fluid diversion devices for hydraulic delivery systems and associated methods |
EP3972673A4 (en) | 2019-05-20 | 2023-06-07 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
WO2020257643A1 (en) | 2019-06-20 | 2020-12-24 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
CR20210640A (en) | 2019-10-29 | 2022-05-30 | Valtech Cardio Ltd | Annuloplasty and tissue anchor technologies |
RU206723U1 (en) * | 2021-02-08 | 2021-09-23 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний" (НИИ КПССЗ) | PERSONALIZED MITRAL VALVE PROSTHESIS RING WITH VARIABLE RIGIDITY |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5104407A (en) * | 1989-02-13 | 1992-04-14 | Baxter International Inc. | Selectively flexible annuloplasty ring |
US6602289B1 (en) * | 1999-06-08 | 2003-08-05 | S&A Rings, Llc | Annuloplasty rings of particular use in surgery for the mitral valve |
US6797001B2 (en) * | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL143127B (en) | 1969-02-04 | 1974-09-16 | Rhone Poulenc Sa | REINFORCEMENT DEVICE FOR A DEFECTIVE HEART VALVE. |
FR2306671A1 (en) | 1975-04-11 | 1976-11-05 | Rhone Poulenc Ind | VALVULAR IMPLANT |
SU577022A1 (en) * | 1976-06-25 | 1977-10-30 | Всесоюзный Научно-Исследовательский Институт Клинической И Экспериментальной Хирургии | Cardiac valve prosthesis |
US5387247A (en) | 1983-10-25 | 1995-02-07 | Sorin Biomedia S.P.A. | Prosthetic device having a biocompatible carbon film thereon and a method of and apparatus for forming such device |
US5084151A (en) | 1985-11-26 | 1992-01-28 | Sorin Biomedica S.P.A. | Method and apparatus for forming prosthetic device having a biocompatible carbon film thereon |
CA1303298C (en) | 1986-08-06 | 1992-06-16 | Alain Carpentier | Flexible cardiac valvular support prosthesis |
IT1196836B (en) | 1986-12-12 | 1988-11-25 | Sorin Biomedica Spa | Polymeric or metal alloy prosthesis with biocompatible carbon coating |
US5133845A (en) | 1986-12-12 | 1992-07-28 | Sorin Biomedica, S.P.A. | Method for making prosthesis of polymeric material coated with biocompatible carbon |
IT1210722B (en) | 1987-05-11 | 1989-09-20 | Sorin Biomedica Spa | DEVICES FOR THE CONDITIONING OF BLOOD FLOWS |
IT1218951B (en) | 1988-01-12 | 1990-04-24 | Mario Morea | PROSTHETIC DEVICE FOR SURGICAL CORRECTION OF TRICUSPIDAL INSUFFICENCE |
US4917698A (en) * | 1988-12-22 | 1990-04-17 | Baxter International Inc. | Multi-segmented annuloplasty ring prosthesis |
IL89359A0 (en) | 1989-02-21 | 1989-09-10 | Scitex Corp Ltd | Computerised apparatus for color selection |
US5041130A (en) | 1989-07-31 | 1991-08-20 | Baxter International Inc. | Flexible annuloplasty ring and holder |
US5135845A (en) | 1990-04-10 | 1992-08-04 | Eastman Kodak Company | Sensitizing dye for photographic materials |
US5064431A (en) | 1991-01-16 | 1991-11-12 | St. Jude Medical Incorporated | Annuloplasty ring |
AU670934B2 (en) | 1992-01-27 | 1996-08-08 | Medtronic, Inc. | Annuloplasty and suture rings |
FR2708458B1 (en) | 1993-08-03 | 1995-09-15 | Seguin Jacques | Prosthetic ring for cardiac surgery. |
US6217610B1 (en) * | 1994-07-29 | 2001-04-17 | Edwards Lifesciences Corporation | Expandable annuloplasty ring |
EP0871417B1 (en) | 1995-12-01 | 2003-10-01 | Medtronic, Inc. | Annuloplasty prosthesis |
US5843117A (en) * | 1996-02-14 | 1998-12-01 | Inflow Dynamics Inc. | Implantable vascular and endoluminal stents and process of fabricating the same |
IT1285308B1 (en) | 1996-03-12 | 1998-06-03 | Sorin Biomedica Cardio Spa | PROCEDURE FOR THE PREPARATION OF BIOLOGICAL MATERIAL FOR PLANT |
US5716397A (en) | 1996-12-06 | 1998-02-10 | Medtronic, Inc. | Annuloplasty device with removable stiffening element |
US6309414B1 (en) * | 1997-11-04 | 2001-10-30 | Sorin Biomedica Cardio S.P.A. | Angioplasty stents |
US6143024A (en) | 1998-06-04 | 2000-11-07 | Sulzer Carbomedics Inc. | Annuloplasty ring having flexible anterior portion |
US6250308B1 (en) | 1998-06-16 | 2001-06-26 | Cardiac Concepts, Inc. | Mitral valve annuloplasty ring and method of implanting |
US6106550A (en) * | 1998-07-10 | 2000-08-22 | Sulzer Carbomedics Inc. | Implantable attaching ring |
US6102945A (en) * | 1998-10-16 | 2000-08-15 | Sulzer Carbomedics, Inc. | Separable annuloplasty ring |
US6406493B1 (en) | 2000-06-02 | 2002-06-18 | Hosheng Tu | Expandable annuloplasty ring and methods of use |
US6749630B2 (en) | 2001-08-28 | 2004-06-15 | Edwards Lifesciences Corporation | Tricuspid ring and template |
US6908482B2 (en) | 2001-08-28 | 2005-06-21 | Edwards Lifesciences Corporation | Three-dimensional annuloplasty ring and template |
US20030199974A1 (en) | 2002-04-18 | 2003-10-23 | Coalescent Surgical, Inc. | Annuloplasty apparatus and methods |
-
2002
- 2002-03-27 AT AT02425190T patent/ATE451080T1/en not_active IP Right Cessation
- 2002-03-27 EP EP09177502A patent/EP2153799B1/en not_active Expired - Lifetime
- 2002-03-27 ES ES09177502T patent/ES2370585T3/en not_active Expired - Lifetime
- 2002-03-27 DE DE60234675T patent/DE60234675D1/en not_active Expired - Lifetime
- 2002-03-27 AT AT09177502T patent/ATE518501T1/en not_active IP Right Cessation
- 2002-03-27 EP EP02425190A patent/EP1348406B1/en not_active Expired - Lifetime
-
2003
- 2003-03-20 US US10/393,448 patent/US7220277B2/en not_active Expired - Lifetime
-
2007
- 2007-04-19 US US11/737,474 patent/US20070191940A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5104407A (en) * | 1989-02-13 | 1992-04-14 | Baxter International Inc. | Selectively flexible annuloplasty ring |
US5104407B1 (en) * | 1989-02-13 | 1999-09-21 | Baxter Int | Selectively flexible annuloplasty ring |
US6602289B1 (en) * | 1999-06-08 | 2003-08-05 | S&A Rings, Llc | Annuloplasty rings of particular use in surgery for the mitral valve |
US6797001B2 (en) * | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070162112A1 (en) * | 2005-12-28 | 2007-07-12 | Sorin Biomedica Cardio | Annuloplasty prosthesis with an auxetic structure |
US8034103B2 (en) | 2005-12-28 | 2011-10-11 | Sorin Biomedica Cardio S.R.L. | Annuloplasty prosthesis with an auxetic structure |
US20080086203A1 (en) * | 2006-10-06 | 2008-04-10 | Roberts Harold G | Mitral and tricuspid annuloplasty rings |
US7879087B2 (en) * | 2006-10-06 | 2011-02-01 | Edwards Lifesciences Corporation | Mitral and tricuspid annuloplasty rings |
US20110093065A1 (en) * | 2006-10-06 | 2011-04-21 | Edwards Lifesciences Corporation | Mitral and Tricuspid Annuloplasty Rings |
US8382828B2 (en) * | 2006-10-06 | 2013-02-26 | Edwards Lifesciences Corporation | Mitral annuloplasty rings |
US8529620B2 (en) | 2007-05-01 | 2013-09-10 | Ottavio Alfieri | Inwardly-bowed tricuspid annuloplasty ring |
US8992606B2 (en) | 2010-03-19 | 2015-03-31 | Xavier Ruyra Baliarda | Prosthetic device for repairing a mitral valve |
US8932350B2 (en) | 2010-11-30 | 2015-01-13 | Edwards Lifesciences Corporation | Reduced dehiscence annuloplasty ring |
US9474607B2 (en) | 2010-11-30 | 2016-10-25 | Edwards Lifesciences Corporation | Methods of implanting an annuloplasty ring for reduced dehiscence |
US10543089B2 (en) | 2010-11-30 | 2020-01-28 | Edwards Lifesciences Corporation | Annuloplasty ring with reduced dehiscence |
US11872132B2 (en) | 2010-11-30 | 2024-01-16 | Edwards Lifesciences Corporation | Methods of implanting an annuloplasty ring for reduced dehiscence |
CN105407838A (en) * | 2013-06-05 | 2016-03-16 | Lc疗法有限公司 | Annuloplasty device |
US9155622B2 (en) | 2013-08-14 | 2015-10-13 | Sorin Group Italia S.R.L. | Apparatus and method for chordal replacement |
US9700413B2 (en) | 2013-08-14 | 2017-07-11 | Sorin Group Italia, S.r.l. | Apparatus and method for chordal replacement |
CN107753152A (en) * | 2016-08-22 | 2018-03-06 | 北京市普惠生物医学工程有限公司 | Valve forming ring |
Also Published As
Publication number | Publication date |
---|---|
EP2153799A1 (en) | 2010-02-17 |
EP1348406A1 (en) | 2003-10-01 |
EP1348406B1 (en) | 2009-12-09 |
DE60234675D1 (en) | 2010-01-21 |
ATE518501T1 (en) | 2011-08-15 |
US7220277B2 (en) | 2007-05-22 |
ATE451080T1 (en) | 2009-12-15 |
EP2153799B1 (en) | 2011-08-03 |
ES2370585T3 (en) | 2011-12-20 |
US20030220686A1 (en) | 2003-11-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7220277B2 (en) | Prosthesis for annuloplasty comprising a perforated element | |
US11903830B2 (en) | Physiologically harmonized repair of tricuspid valve | |
US10166101B2 (en) | Methods for repairing mitral valves | |
US10188518B2 (en) | Annuloplasty ring with variable cross-section | |
US5776189A (en) | Cardiac valvular support prosthesis | |
EP1951154B1 (en) | Saddle-shaped mitral valve annuloplasty prostheses | |
EP1684670B1 (en) | Annulopasty rings for repair of abnormal mitral valves. | |
US8114155B2 (en) | Annuloplasty ring with offset free ends | |
EP3307208B1 (en) | Asymmetric mitral annuloplasty band | |
EP0860151A1 (en) | Cardiac valvular support prosthesis | |
EP1850794A1 (en) | Mitral valve annuloplasty ring having a posterior bow | |
JPH09503679A (en) | Cardiac surgery prosthetic ring | |
CA2785509A1 (en) | Bimodal tricuspid annuloplasty ring | |
CA2195619A1 (en) | Cardiac valvular support prosthesis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SORIN BIOMEDICA CARDIO S.P.A., ITALY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ARRU, PIETRO;BERGAMASCO, GIOVANNI;STACCHINO, CARLA;REEL/FRAME:021141/0619 Effective date: 20030508 |
|
AS | Assignment |
Owner name: SORIN BIOMEDICA CARDIO S.R.L., ITALY Free format text: CHANGE OF NAME;ASSIGNOR:SORIN BIOMEDICA CARDIO S.P.A.;REEL/FRAME:021876/0393 Effective date: 20041006 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |