US20070233097A1 - Methods and devices for spinal fixation element placement - Google Patents
Methods and devices for spinal fixation element placement Download PDFInfo
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- US20070233097A1 US20070233097A1 US11/760,064 US76006407A US2007233097A1 US 20070233097 A1 US20070233097 A1 US 20070233097A1 US 76006407 A US76006407 A US 76006407A US 2007233097 A1 US2007233097 A1 US 2007233097A1
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- tool
- guide
- rod
- bone screw
- spinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7074—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling
- A61B17/7076—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling for driving, positioning or assembling spinal clamps or bone anchors specially adapted for spinal fixation
- A61B17/7082—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling for driving, positioning or assembling spinal clamps or bone anchors specially adapted for spinal fixation for driving, i.e. rotating, screws or screw parts specially adapted for spinal fixation, e.g. for driving polyaxial or tulip-headed screws
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7002—Longitudinal elements, e.g. rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7074—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling
- A61B17/7076—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling for driving, positioning or assembling spinal clamps or bone anchors specially adapted for spinal fixation
- A61B17/7077—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling for driving, positioning or assembling spinal clamps or bone anchors specially adapted for spinal fixation for moving bone anchors attached to vertebrae, thereby displacing the vertebrae
- A61B17/7079—Tools requiring anchors to be already mounted on an implanted longitudinal or transverse element, e.g. where said element guides the anchor motion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7074—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling
- A61B17/7083—Tools for guidance or insertion of tethers, rod-to-anchor connectors, rod-to-rod connectors, or longitudinal elements
- A61B17/7085—Tools for guidance or insertion of tethers, rod-to-anchor connectors, rod-to-rod connectors, or longitudinal elements for insertion of a longitudinal element down one or more hollow screw or hook extensions, i.e. at least a part of the element within an extension has a component of movement parallel to the extension's axis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7074—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling
- A61B17/7091—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling for applying, tightening or removing longitudinal element-to-bone anchor locking elements, e.g. caps, set screws, nuts or wedges
Definitions
- This application relates to tools for use in spinal surgery, and in particular to minimally invasive methods and devices for introducing a spinal fixation element to one or more spinal anchor sites within a patient's spine.
- spinal fixation devices are used in orthopedic surgery to align and/or fix a desired relationship between adjacent vertebral bodies.
- Such devices typically include a spinal fixation element, such as a relatively rigid fixation rod, that is coupled to adjacent vertebrae by attaching the element to various anchoring devices, such as hooks, bolts, wires, or screws.
- the fixation elements can have a predetermined contour that has been designed according to the properties of the target implantation site, and once installed, the instrument holds the vertebrae in a desired spatial relationship, either until desired healing or spinal fusion has taken place, or for some longer period of time.
- Spinal fixation elements can be anchored to specific portions of the vertebrae. Since each vertebra varies in shape and size, a variety of anchoring devices have been developed to facilitate engagement of a particular portion of the bone.
- Pedicle screw assemblies for example, have a shape and size that is configured to engage pedicle bone. Such screws typically include a threaded shank that is adapted to be threaded into a vertebra, and a head portion having a rod-receiving element, usually in the form of a U-shaped slot formed in the head.
- a set-screw, plug, or similar type of fastening mechanism is used to lock the fixation element, e.g., a spinal rod, into the rod-receiving head of the pedicle screw.
- each screw In use, the shank portion of each screw is threaded into a vertebra, and once properly positioned, a rod is seated through the rod-receiving member of each screw and the rod is locked in place by tightening a cap or other fastener mechanism to securely interconnect each screw and the fixation rod.
- the present invention generally provides methods for introducing a spinal fixation element into a receiver head of adjacent spinal anchors.
- the method utilizes at least two percutaneous access devices, each of which has a proximal end positioned outside a patient's body and a distal end coupled to a spinal anchor.
- the access device preferably includes at least one sidewall opening extending from the distal end through at least a portion of the percutaneous access device.
- a spinal fixation element is positioned through the sidewall opening(s) in at least two adjacent percutaneous access devices such that the spinal fixation element extends in an orientation that is substantially transverse to a longitudinal axis of each percutaneous access device.
- the spinal fixation element is then advanced in the substantially transverse orientation to seat the spinal fixation element in or adjacent to the receiver head of at least two spinal anchors that are preferably implanted within adjacent vertebrae.
- each percutaneous access device includes first and second opposed sidewall openings, and at least one of the first and second sidewall openings extends from the distal end and terminates at a position distal to the proximal end.
- the percutaneous access devices can also optionally include a cannula, sleeve, or similar device disposed therearound that is effective to prevent removal of each percutaneous device from the spinal anchor coupled thereto.
- the sleeve preferably includes at least one sidewall opening formed therein that is adapted to align with the at least one sidewall opening in the percutaneous access device.
- a percutaneous access system for introducing a spinal fixation element into a patient's body.
- the system includes at least two spinal anchors that are adapted to be disposed in bone, at least one elongate, generally cylindrical hollow tube having at least one sidewall opening extending from the distal end thereof and terminating at a position distal to the proximal end, and a spinal fixation element.
- the system can also include at least one sleeve which is adapted to be slidably disposed around at least a portion of one of the hollow tubes.
- the sleeve(s) preferably includes at least one sidewall opening formed therein that is adapted to align with the sidewall opening(s) formed in the hollow tube.
- the system can also include a driver mechanism having a proximal handle portion, and a distal end that is adapted to couple to a spinal anchor such that rotation of the driver mechanism is effective to thread the spinal anchor into bone.
- the driver mechanism is preferably adapted to be disposed through the hollow tube(s).
- FIG. 1 is a perspective view of a percutaneous access device coupled to a spinal anchor according to one embodiment of the present invention
- FIG. 2 is a cross-sectional view taken along the longitudinal axis L of the percutaneous access device shown in FIG. 1 ;
- FIG. 3A is a posterior view of a midline incision formed in the thoracolumbar fascia of a patient's back;
- FIG. 3B is an end view showing a blunt dissection of the muscles surrounding a patient's vertebra
- FIG. 4 is an end view of the vertebra shown in FIG. 3B showing a technique for separating the muscles along the muscle plane to gain access to the vertebra;
- FIG. 5 is an end view of the vertebra shown in FIG. 4 showing placement of a k-wire through the incision and into the patient's vertebra;
- FIG. 6 is an end view of the vertebra shown in FIG. 5 having an obturator and several dilators disposed over the k-wire to dilate the tissue and muscles;
- FIG. 7 is perspective view of a spinal anchor having a percutaneous access device coupled thereto and extending through an incision formed in the patient's tissue surface to implant the spinal anchor in a vertebra;
- FIG. 8 is a perspective view of two percutaneous access devices attached to spinal anchors that are disposed within adjacent vertebrae in a patient's spinal column;
- FIG. 9 illustrates a method for introducing a spinal fixation element through the percutaneous access devices shown in FIG. 8 ;
- FIG. 10 is a perspective view of the spinal fixation element shown in FIG. 9 being advanced toward the spinal anchors using a pusher device;
- FIG. 11 is a perspective view of the spinal fixation element shown in FIG. 10 after it is fully positioned within receiver heads of the adjacent spinal anchors;
- FIG. 12 is a perspective view of a compression tool positioned around the percutaneous access devices shown in FIG. 11 and compressing the devices toward one another;
- FIG. 13 is a perspective view of a closure mechanism being applied through one of the percutaneous access devices to lock the spinal fixation element in relation to the spinal anchor.
- the present invention provides minimally invasive methods and devices for introducing a spinal fixation element into a surgical site in a patient's spinal column.
- the method involves positioning a spinal fixation element through openings formed in at least two adjacent percutaneous access devices such that the spinal fixation element extends between the at least two adjacent percutaneous access devices in a lengthwise orientation.
- the spinal fixation element can then be advanced in a distal direction to seat the spinal fixation element in the receiver heads of the adjacent spinal anchors, or to otherwise position the spinal fixation element in relation to the adjacent spinal anchors.
- a fastening element or other closure mechanism can optionally be applied to each spinal anchor to engage the spinal fixation element within the receiver heads of the adjacent anchors, or to otherwise directly or indirectly connect the spinal fixation element to the anchors.
- FIGS. 1 and 2 illustrate an exemplary embodiment of a percutaneous access device 12 that is mated to a spinal anchor 50 to form a spinal implant assembly 10 .
- the device 12 is in the form of a generally elongate, cylindrical tube having an inner lumen 12 c formed therein and defining a longitudinal axis L that extends between proximal and distal ends 12 a , 12 b .
- the size of the access device 12 can vary depending on the intended use, but it should have a length l that allows the proximal end 12 a of the access device 12 to be positioned outside the patient's body, while the distal end 12 b of the access device 12 is coupled to, or positioned adjacent to, a spinal anchor, e.g., anchor 50 , that is disposed in a vertebra in a patient's spine.
- the inner diameter d i of the access device 12 can also vary depending on the intended use, but the inner diameter d i is preferably sufficient to accommodate a diameter or width of a spinal fixation element to be introduced therethrough.
- the percutaneous access device 12 also preferably includes at least one sidewall opening or slot 14 , and more preferably two opposed sidewall openings (only one opening 14 is shown), formed therein and extending proximally from the distal end 12 b thereof.
- the openings 14 allow a spinal fixation element to be positioned lengthwise between two adjacent devices 12 such that the spinal fixation element extends in an orientation that is substantially transverse to the longitudinal axis L of the access devices 12 , i.e., that crosses the longitudinal axis L of the access devices 12 .
- the exact position of the spinal fixation element with respect to the longitudinal axis L will of course vary depending on the configuration of the spinal fixation element.
- the shape and size of the openings 14 can also vary depending on the configuration of the spinal fixation element, but the openings 14 preferably have a generally elongate shape with a width w that is sufficient to accommodate the diameter of the spinal fixation element.
- the openings 14 preferably extend over about half of the length, or more than half of the length, of the percutaneous access device 12 . This allows a proximal portion of each opening 14 to be positioned outside a patient's body while the device 12 is in use, thus allowing a spinal fixation element to be externally positioned through the openings 14 and then moved distally to be implanted.
- the percutaneous access device 12 can include any number of sidewall openings having any shape that is sufficient to allow a spinal fixation element to be positioned therethrough.
- the percutaneous access device 12 is preferably adapted to attach to a spinal anchor 50 , and more preferably to the receiver head 52 of a spinal anchor 50 .
- the distal end 12 c of the percutaneous access device 12 can include one or more mating elements 18 formed thereon or therein for engaging the spinal anchor 50 .
- Suitable mating elements include, for example, threads, a twist-lock engagement, a snap-on engagement, or any other technique known in the art, and in an exemplary embodiment the mating elements are formed on opposed inner surfaces of the distal end 12 b of the access device 12 .
- a sleeve (not shown) or other device preferably having sidewall openings that correspond with the sidewall openings 14 formed in the percutaneous access device 12 , can also be placed over the percutaneous access device 12 , and optionally over the anchor 50 as well, to prevent disengagement of the access device 12 from the anchor 50 during use.
- Exemplary techniques for mating the percutaneous access device 12 to a spinal anchor are disclosed in a patent application entitled “Percutaneous Access Devices and Bone Anchor Assemblies,” filed concurrently herewith. A person skilled in the art will appreciate that a variety of other techniques can be used to removably mate the percutaneous access device to a spinal anchor.
- FIG. 1 an exemplary spinal anchor for use with the methods and devices of the present invention is shown.
- implants can be used with the devices and methods of the present invention, including, for example, spinal screws, hooks, bolts, and wires.
- FIG. 1 illustrates a spinal screw 50 that includes a distal, bone-engaging portion, e.g., a threaded shank 54 , and a proximal, U-shaped, receiver head 52 that is adapted to seat a spinal fixation element, such as a spinal rod (not shown).
- a spinal fixation element such as a spinal rod (not shown).
- the threaded shank 54 can be fixedly attached to the receiver head 52 to form a monoaxial screw, or alternatively the shank 54 can be configured as a polyaxial screw, as shown, that is rotatably disposed through an opening formed in the distal end of the receiver head 52 to allow rotation of the shank 54 with respect to the receiver head 52 .
- a variety of techniques can be used to allow rotation of the head 52 with respect to the shank 54 .
- FIGS. 3A-13 show a minimally invasive method of implanting a spinal fixation element into the receiver heads of adjacent spinal anchors. While the method is shown and described in connection with the percutaneous access device 12 and spinal screw 50 disclosed herein, a person skilled in the art will appreciate that the method is not limited to use with such devices, and that a variety of other devices known in the art can be used. Moreover, while only two access devices 12 , 12 ′ and two implants 50 , 50 ′ are shown in FIGS. 8-13 , the method of the present invention can be performed using any number of access devices and spinal anchors. The method can also be performed using only some of the method steps disclosed herein, and/or using other methods known in the art.
- the procedure preferably begins by forming an incision through the tissue located adjacent to the desired implant site. While the location, shape, and size of the incision will depend on the type and quantity of spinal anchors being implanted, FIG. 3A illustrates a midline, blunt dissection incision 62 formed in the thoracolumbar fascia in the patient's back along the muscle plane. The length of the incision 62 is about 4-5 cm, however this can vary depending on the procedure. Once the midline incision 62 is formed, blunt finger dissection can be used, as shown in FIG. 4 , to separate the longissimus thoracis and multifidus muscles, thereby exposing the facet and the junction of the transverse process and superior articular process.
- a guide wire e.g., a k-wire 64
- the k-wire 64 preferably extends between the muscles and into the vertebra at the desired entry point of the spinal anchor. Fluoroscopy is typically used to facilitate proper placement of the k-wire 64 .
- FIG. 6 illustrates dilation at one end of the incision 62 using an obturator 66 a having several dilators 66 b , 66 c of increasing size placed there over.
- the dilators 66 b , 66 c are delivered over the obturator 66 a and k-wire 64 to essentially stretch the skin around the incision 62 and to expand the pathway to the anchor site.
- the incision 62 can optionally be held opening using a retractor or an expandable cannula.
- an anchor can be delivered to each anchor site, as shown in FIG. 7 .
- This procedure typically involves preparation of the vertebra 60 using one or more bone preparation instruments, such as drills, taps, awls, burrs, probes, etc.
- one or more cannulae can be used to provide a pathway from the incision 62 to the anchor site for insertion of the bone preparation instruments and/or the anchor.
- a relatively small cannula is used to introduce bone preparation instruments into the surgical site.
- the incision 62 can then be further dilated, and the small cannula can be replaced with a larger cannula that is adapted to receive or mate to the anchor.
- a spinal anchor can be implanted at each implant site.
- An access device 12 , 12 ′ can be mated to each anchor 50 , 50 ′ after insertion of the anchor 50 , 50 ′ into bone 60 , 60 ′, but more preferably each percutaneous access device 12 , 12 ′ is attached to the anchor 50 , 50 ′ prior to insertion of the anchor 50 , 50 ′ into bone 60 , 60 ′ to provide a passageway for a driver tool for driving the anchor 50 into bone 60 , 60 ′.
- FIG. 7 illustrates anchor 50 implanted in a first vertebra 60 and having access device 12 attached thereto.
- FIG. 7 further illustrates a second anchor 50 ′ having an access device 12 ′ mated thereto.
- the screw 50 ′ is about to be implanted in a second vertebra 60 ′ that is adjacent to the first vertebra 60 .
- a driver tool 200 can be positioned through the access device 12 ′ and coupled to the receiver head 52 ′ of the screw 50 ′ to drive the screw 50 ′ into the vertebra 60 ′.
- a sleeve can be placed over each access device 12 , 12 ′, either prior to or after the devices 12 , 12 ′, 50 , 50 ′ are implanted, to prevent the devices 12 , 12 ′ from becoming disengaged from the anchors 50 , 50 ′ to which they are attached.
- the sleeve 100 which is partially illustrated in FIG. 3B , is preferably in the form of a cannula that has substantially the same configuration as each access device 12 , 12 ′.
- a sleeve is particularly desirable where the access devices 12 , 12 ′ utilize pin members that engage corresponding detents formed on an outer surface of each screw head 52 , 52 ′, as the sleeve will prevent the pin members from becoming disengaged from the detents.
- the sleeve can also optionally serve as an access device, allowing access devices 12 , 12 ′ to be detached and removed from the anchors 50 , 50 ′.
- a spinal fixation element is delivered to the anchor sites.
- the spinal fixation element 70 is positioned through the openings 14 , 14 ′ in the adjacent devices 12 , 12 ′ such that the spinal fixation element 70 extends in a lengthwise orientation which is substantially transverse to the longitudinal axis L of the access devices 12 , 12 ′.
- the exact angle of the fixation element 70 with respect to the percutaneous access devices 12 , 12 ′ will vary depending on the orientation of the access device 12 , 12 ′ with respect to the patient's spinal column, and it is understood that the orientation can vary during use since the percutaneous access devices 12 , 12 ′ can be oriented at various angles throughout the surgical procedure.
- the spinal fixation element 70 is then moved distally toward the distal end 12 b , 12 b ′ of the percutaneous access devices 12 , 12 ′. As the spinal fixation element 70 moves distally, it will advantageously pass between the muscles, thus eliminating the need to cut or tear tissue.
- the method is also particularly advantageous in that the percutaneous access devices 12 , 12 ′ direct the spinal fixation element 70 into the receiver heads 52 , 52 ′ of the adjacent spinal anchors 50 , 50 ′, thus allowing the spinal fixation element to be properly positioned without the necessity for direct visual access to the surgical site.
- Movement of the spinal fixation element 70 in the distal direction can be achieved using pusher shaft 80 , as shown in FIGS. 10 and 11 .
- the pusher shaft 80 can have a variety of configurations, but it should be effective to allow controlled movement of the spinal fixation element 70 .
- a person skilled in the art will appreciate that a variety of other techniques can be used to advance the spinal fixation element 70 distally between the percutaneous access devices 12 , 12 ′ to seat the spinal fixation element 70 into the receiver heads 52 , 52 ′ of adjacent spinal anchors 50 , 50 ′.
- the pusher shaft 80 includes a seating member 82 formed on a distal end thereof that is adapted to seat the spinal fixation element 70 .
- the seating member 82 which is similar to a receiver head of a spinal anchor, is generally cylindrical and includes an open distal end with opposed U-shaped cut-out portions formed therein for receiving the spinal fixation element 70 .
- the seating member 82 is positioned around the spinal fixation element 70 and a force is applied to the pusher shaft 80 to move the spinal fixation element 70 distally.
- the pusher shaft 80 can then be removed or detached from the spinal fixation element 70 , and a closure mechanism can be applied to one or both receiver heads 52 , 52 ′ to retain the spinal fixation element 70 therein.
- a compression tool 100 is used to compress the access devices 12 , 12 ′ toward one another prior to applying a closure mechanism to each anchor 50 , 50 ′.
- the closure mechanism(s) can, however, be partially applied before compression.
- FIG. 12 An exemplary compression tool 100 is shown in FIG. 12 , and in general it includes opposed arms 102 , 104 that are pivotally coupled to one another at a substantial mid-point thereof such that each arm 102 , 104 includes a distal portion 102 b , 104 b that is adapted to be disposed around a percutaneous access device 12 , 12 ′, and a proximal, handle portion 102 a , 104 a .
- the device 100 can also include a fulcrum (not shown) that is disposed between the arms 102 , 104 to facilitate controlled movement of the arms 102 , 104 with respect to one another.
- each arm 102 , 104 is placed around an access device 12 , 12 ′, preferably around the distal end 12 b , 12 b ′ of each device 12 , 12 ′ and/or around the head 52 , 52 ′ of each anchor 50 , 50 ′.
- the proximal, handle portions 102 a , 104 a are then brought toward one another to move the access devices 12 , 12 ′ toward one another, preferably while maintaining relative spacing therebetween, as shown in FIG. 12 .
- FIG. 13 illustrates a driver tool 90 disposed through access device 12 for applying a closure mechanism, such as a set screw, to the receiver head 52 of the spinal anchor 50 to lock the spinal fixation element 70 with respect to the spinal anchor 50 .
- a closure mechanism such as a set screw
- spinal fixation element 70 does not need to be directly attached to each anchor 50 , 50 ′, and that it can be indirectly attached to the anchors 50 , 50 ′ using, for example, a band clamp, or slotted or offset connectors.
- the access devices 12 , 12 ′ can be removed (if attached) from the implants 50 , 50 ′, leaving only a single, relatively small incision in the patient where each access device 12 , 12 ′ and the spinal fixation element 70 was introduced. This is particularly advantageous in that it reduces the amount of trauma caused to the patient, and it minimizes the damage to muscle surrounding the surgical site.
- the method can be performed in any sequence using any of the steps.
- the access devices of the present invention can be used to deliver multiple spinal fixation elements simultaneously or sequentially, and/or to perform a variety of other surgical procedures not illustrated or described herein.
Abstract
Minimally invasive methods and devices are provided for positioning a spinal fixation element in relation to adjacent spinal anchors. In an exemplary embodiment, the device is a percutaneous access device that can be coupled to a spinal anchor, and the method includes the step of positioning a spinal fixation element through at least one sidewall opening of at least two percutaneous access devices such that the spinal fixation element extends in a lengthwise orientation that is substantially transverse to the longitudinal axis of each percutaneous access device. The spinal fixation element can then be advanced in the lengthwise orientation to seat the spinal fixation element in or adjacent to the receiver heads of at least two adjacent spinal anchors. A fastening element or other closure mechanism can then be applied to each spinal anchor to engage the spinal fixation element within the receiver heads of the adjacent anchors.
Description
- This application is a continuation of U.S. patent application Ser. No. 10/737,537 filed on Dec. 16, 2003 and entitled “Methods and Devices for Spinal Fixation Element Placement,” which is hereby incorporated by reference in its entirety.
- This application relates to tools for use in spinal surgery, and in particular to minimally invasive methods and devices for introducing a spinal fixation element to one or more spinal anchor sites within a patient's spine.
- For a number of known reasons, spinal fixation devices are used in orthopedic surgery to align and/or fix a desired relationship between adjacent vertebral bodies. Such devices typically include a spinal fixation element, such as a relatively rigid fixation rod, that is coupled to adjacent vertebrae by attaching the element to various anchoring devices, such as hooks, bolts, wires, or screws. The fixation elements can have a predetermined contour that has been designed according to the properties of the target implantation site, and once installed, the instrument holds the vertebrae in a desired spatial relationship, either until desired healing or spinal fusion has taken place, or for some longer period of time.
- Spinal fixation elements can be anchored to specific portions of the vertebrae. Since each vertebra varies in shape and size, a variety of anchoring devices have been developed to facilitate engagement of a particular portion of the bone. Pedicle screw assemblies, for example, have a shape and size that is configured to engage pedicle bone. Such screws typically include a threaded shank that is adapted to be threaded into a vertebra, and a head portion having a rod-receiving element, usually in the form of a U-shaped slot formed in the head. A set-screw, plug, or similar type of fastening mechanism is used to lock the fixation element, e.g., a spinal rod, into the rod-receiving head of the pedicle screw. In use, the shank portion of each screw is threaded into a vertebra, and once properly positioned, a rod is seated through the rod-receiving member of each screw and the rod is locked in place by tightening a cap or other fastener mechanism to securely interconnect each screw and the fixation rod.
- Recently, the trend in spinal surgery has been moving toward providing minimally invasive devices and methods for implanting spinal fixation devices. One such method, for example, is disclosed in U.S. Pat. No. 6,530,929 of Justis et al. and it utilizes two percutaneous access devices for implanting an anchoring device, such as a spinal screw, into adjacent vertebrae. A spinal rod is then introduced through a third incision a distance apart from the percutaneous access sites, and the rod is transversely moved into the rod-engaging portion of each spinal screw. The percutaneous access devices can then be used to apply closure mechanisms to the rod-engaging heads to lock the rod therein. While this procedure offers advantages over prior art invasive techniques, the transverse introduction of the rod can cause significant damage to surrounding tissue and muscle. Moreover, the use of three separate access sites can undesirably lengthen the surgical procedure, and increase patient trauma and recovery time.
- Accordingly, there remains a need for improved minimally invasive devices and methods for introducing a spinal fixation element into a patient's spine.
- The present invention generally provides methods for introducing a spinal fixation element into a receiver head of adjacent spinal anchors. In one embodiment, the method utilizes at least two percutaneous access devices, each of which has a proximal end positioned outside a patient's body and a distal end coupled to a spinal anchor. The access device preferably includes at least one sidewall opening extending from the distal end through at least a portion of the percutaneous access device. In use, a spinal fixation element is positioned through the sidewall opening(s) in at least two adjacent percutaneous access devices such that the spinal fixation element extends in an orientation that is substantially transverse to a longitudinal axis of each percutaneous access device. The spinal fixation element is then advanced in the substantially transverse orientation to seat the spinal fixation element in or adjacent to the receiver head of at least two spinal anchors that are preferably implanted within adjacent vertebrae.
- In an exemplary embodiment, each percutaneous access device includes first and second opposed sidewall openings, and at least one of the first and second sidewall openings extends from the distal end and terminates at a position distal to the proximal end. The percutaneous access devices can also optionally include a cannula, sleeve, or similar device disposed therearound that is effective to prevent removal of each percutaneous device from the spinal anchor coupled thereto. The sleeve preferably includes at least one sidewall opening formed therein that is adapted to align with the at least one sidewall opening in the percutaneous access device.
- In another embodiment of the present invention, a percutaneous access system for introducing a spinal fixation element into a patient's body is provided. The system includes at least two spinal anchors that are adapted to be disposed in bone, at least one elongate, generally cylindrical hollow tube having at least one sidewall opening extending from the distal end thereof and terminating at a position distal to the proximal end, and a spinal fixation element. The system can also include at least one sleeve which is adapted to be slidably disposed around at least a portion of one of the hollow tubes. The sleeve(s) preferably includes at least one sidewall opening formed therein that is adapted to align with the sidewall opening(s) formed in the hollow tube. The system can also include a driver mechanism having a proximal handle portion, and a distal end that is adapted to couple to a spinal anchor such that rotation of the driver mechanism is effective to thread the spinal anchor into bone. The driver mechanism is preferably adapted to be disposed through the hollow tube(s).
-
FIG. 1 is a perspective view of a percutaneous access device coupled to a spinal anchor according to one embodiment of the present invention; -
FIG. 2 is a cross-sectional view taken along the longitudinal axis L of the percutaneous access device shown inFIG. 1 ; -
FIG. 3A is a posterior view of a midline incision formed in the thoracolumbar fascia of a patient's back; -
FIG. 3B is an end view showing a blunt dissection of the muscles surrounding a patient's vertebra; -
FIG. 4 is an end view of the vertebra shown inFIG. 3B showing a technique for separating the muscles along the muscle plane to gain access to the vertebra; -
FIG. 5 is an end view of the vertebra shown inFIG. 4 showing placement of a k-wire through the incision and into the patient's vertebra; -
FIG. 6 is an end view of the vertebra shown inFIG. 5 having an obturator and several dilators disposed over the k-wire to dilate the tissue and muscles; -
FIG. 7 is perspective view of a spinal anchor having a percutaneous access device coupled thereto and extending through an incision formed in the patient's tissue surface to implant the spinal anchor in a vertebra; -
FIG. 8 is a perspective view of two percutaneous access devices attached to spinal anchors that are disposed within adjacent vertebrae in a patient's spinal column; -
FIG. 9 illustrates a method for introducing a spinal fixation element through the percutaneous access devices shown inFIG. 8 ; -
FIG. 10 is a perspective view of the spinal fixation element shown inFIG. 9 being advanced toward the spinal anchors using a pusher device; -
FIG. 11 is a perspective view of the spinal fixation element shown inFIG. 10 after it is fully positioned within receiver heads of the adjacent spinal anchors; -
FIG. 12 is a perspective view of a compression tool positioned around the percutaneous access devices shown inFIG. 11 and compressing the devices toward one another; and -
FIG. 13 is a perspective view of a closure mechanism being applied through one of the percutaneous access devices to lock the spinal fixation element in relation to the spinal anchor. - The present invention provides minimally invasive methods and devices for introducing a spinal fixation element into a surgical site in a patient's spinal column. In general, the method involves positioning a spinal fixation element through openings formed in at least two adjacent percutaneous access devices such that the spinal fixation element extends between the at least two adjacent percutaneous access devices in a lengthwise orientation. The spinal fixation element can then be advanced in a distal direction to seat the spinal fixation element in the receiver heads of the adjacent spinal anchors, or to otherwise position the spinal fixation element in relation to the adjacent spinal anchors. A fastening element or other closure mechanism can optionally be applied to each spinal anchor to engage the spinal fixation element within the receiver heads of the adjacent anchors, or to otherwise directly or indirectly connect the spinal fixation element to the anchors.
- While a variety of devices can be used to perform the methods of the present invention,
FIGS. 1 and 2 illustrate an exemplary embodiment of apercutaneous access device 12 that is mated to aspinal anchor 50 to form aspinal implant assembly 10. Thedevice 12 is in the form of a generally elongate, cylindrical tube having aninner lumen 12 c formed therein and defining a longitudinal axis L that extends between proximal anddistal ends access device 12 can vary depending on the intended use, but it should have a length l that allows theproximal end 12 a of theaccess device 12 to be positioned outside the patient's body, while thedistal end 12 b of theaccess device 12 is coupled to, or positioned adjacent to, a spinal anchor, e.g.,anchor 50, that is disposed in a vertebra in a patient's spine. The inner diameter di of theaccess device 12 can also vary depending on the intended use, but the inner diameter di is preferably sufficient to accommodate a diameter or width of a spinal fixation element to be introduced therethrough. - The
percutaneous access device 12 also preferably includes at least one sidewall opening orslot 14, and more preferably two opposed sidewall openings (only oneopening 14 is shown), formed therein and extending proximally from thedistal end 12 b thereof. Theopenings 14 allow a spinal fixation element to be positioned lengthwise between twoadjacent devices 12 such that the spinal fixation element extends in an orientation that is substantially transverse to the longitudinal axis L of theaccess devices 12, i.e., that crosses the longitudinal axis L of theaccess devices 12. The exact position of the spinal fixation element with respect to the longitudinal axis L will of course vary depending on the configuration of the spinal fixation element. The shape and size of theopenings 14 can also vary depending on the configuration of the spinal fixation element, but theopenings 14 preferably have a generally elongate shape with a width w that is sufficient to accommodate the diameter of the spinal fixation element. Theopenings 14 preferably extend over about half of the length, or more than half of the length, of thepercutaneous access device 12. This allows a proximal portion of each opening 14 to be positioned outside a patient's body while thedevice 12 is in use, thus allowing a spinal fixation element to be externally positioned through theopenings 14 and then moved distally to be implanted. A person skilled in the art will appreciate that thepercutaneous access device 12 can include any number of sidewall openings having any shape that is sufficient to allow a spinal fixation element to be positioned therethrough. - Continuing to refer to
FIG. 1 , in use, thepercutaneous access device 12 is preferably adapted to attach to aspinal anchor 50, and more preferably to thereceiver head 52 of aspinal anchor 50. Accordingly, thedistal end 12 c of thepercutaneous access device 12 can include one ormore mating elements 18 formed thereon or therein for engaging thespinal anchor 50. Suitable mating elements include, for example, threads, a twist-lock engagement, a snap-on engagement, or any other technique known in the art, and in an exemplary embodiment the mating elements are formed on opposed inner surfaces of thedistal end 12 b of theaccess device 12. A sleeve (not shown) or other device, preferably having sidewall openings that correspond with thesidewall openings 14 formed in thepercutaneous access device 12, can also be placed over thepercutaneous access device 12, and optionally over theanchor 50 as well, to prevent disengagement of theaccess device 12 from theanchor 50 during use. Exemplary techniques for mating thepercutaneous access device 12 to a spinal anchor are disclosed in a patent application entitled “Percutaneous Access Devices and Bone Anchor Assemblies,” filed concurrently herewith. A person skilled in the art will appreciate that a variety of other techniques can be used to removably mate the percutaneous access device to a spinal anchor. - Still referring to
FIG. 1 , an exemplary spinal anchor for use with the methods and devices of the present invention is shown. A person skilled in the art will appreciate that a variety of implants can be used with the devices and methods of the present invention, including, for example, spinal screws, hooks, bolts, and wires. By way of non-limiting example,FIG. 1 illustrates aspinal screw 50 that includes a distal, bone-engaging portion, e.g., a threadedshank 54, and a proximal, U-shaped,receiver head 52 that is adapted to seat a spinal fixation element, such as a spinal rod (not shown). The threadedshank 54 can be fixedly attached to thereceiver head 52 to form a monoaxial screw, or alternatively theshank 54 can be configured as a polyaxial screw, as shown, that is rotatably disposed through an opening formed in the distal end of thereceiver head 52 to allow rotation of theshank 54 with respect to thereceiver head 52. A variety of techniques can be used to allow rotation of thehead 52 with respect to theshank 54. -
FIGS. 3A-13 show a minimally invasive method of implanting a spinal fixation element into the receiver heads of adjacent spinal anchors. While the method is shown and described in connection with thepercutaneous access device 12 andspinal screw 50 disclosed herein, a person skilled in the art will appreciate that the method is not limited to use with such devices, and that a variety of other devices known in the art can be used. Moreover, while only twoaccess devices implants FIGS. 8-13 , the method of the present invention can be performed using any number of access devices and spinal anchors. The method can also be performed using only some of the method steps disclosed herein, and/or using other methods known in the art. - The procedure preferably begins by forming an incision through the tissue located adjacent to the desired implant site. While the location, shape, and size of the incision will depend on the type and quantity of spinal anchors being implanted,
FIG. 3A illustrates a midline, blunt dissection incision 62 formed in the thoracolumbar fascia in the patient's back along the muscle plane. The length of the incision 62 is about 4-5 cm, however this can vary depending on the procedure. Once the midline incision 62 is formed, blunt finger dissection can be used, as shown inFIG. 4 , to separate the longissimus thoracis and multifidus muscles, thereby exposing the facet and the junction of the transverse process and superior articular process. - As shown in
FIG. 5 , a guide wire, e.g., a k-wire 64, can be implanted, either prior to or after formation of the incision, at each spinal anchor implant site. The k-wire 64 preferably extends between the muscles and into the vertebra at the desired entry point of the spinal anchor. Fluoroscopy is typically used to facilitate proper placement of the k-wire 64. - The opposed ends of the incision can then be dilated to provide a pathway for delivery of a spinal anchor to each implant site.
FIG. 6 illustrates dilation at one end of the incision 62 using an obturator 66 a having several dilators 66 b, 66 c of increasing size placed there over. The dilators 66 b, 66 c are delivered over the obturator 66 a and k-wire 64 to essentially stretch the skin around the incision 62 and to expand the pathway to the anchor site. While not illustrated, a person skilled in the art will appreciate that the incision 62 can optionally be held opening using a retractor or an expandable cannula. - Once the incision 62 is dilated to the proper size, an anchor can be delivered to each anchor site, as shown in
FIG. 7 . This procedure typically involves preparation of the vertebra 60 using one or more bone preparation instruments, such as drills, taps, awls, burrs, probes, etc. While not always necessary, one or more cannulae can be used to provide a pathway from the incision 62 to the anchor site for insertion of the bone preparation instruments and/or the anchor. In an exemplary embodiment, a relatively small cannula is used to introduce bone preparation instruments into the surgical site. The incision 62 can then be further dilated, and the small cannula can be replaced with a larger cannula that is adapted to receive or mate to the anchor. - Once the vertebra 60 is prepared, a spinal anchor can be implanted at each implant site. An
access device anchor anchor percutaneous access device anchor anchor anchor 50 into bone 60, 60′.FIG. 7 illustratesanchor 50 implanted in a first vertebra 60 and havingaccess device 12 attached thereto. While not shown, theanchor 50 is preferably cannulated to allow the k-wire 64 to extend through theanchor 50 and theaccess device 12 to guide thedevices FIG. 7 further illustrates asecond anchor 50′ having anaccess device 12′ mated thereto. As shown, thescrew 50′ is about to be implanted in a second vertebra 60′ that is adjacent to the first vertebra 60. Once thescrew 50′ is positioned adjacent to the vertebra 60′, a driver tool 200 can be positioned through theaccess device 12′ and coupled to thereceiver head 52′ of thescrew 50′ to drive thescrew 50′ into the vertebra 60′. - In another embodiment, a sleeve can be placed over each
access device devices devices anchors FIG. 3B , is preferably in the form of a cannula that has substantially the same configuration as eachaccess device access devices screw head access devices anchors - After the anchors are implanted, as shown in
FIG. 8 , a spinal fixation element is delivered to the anchor sites. As shown inFIG. 9 , the spinal fixation element 70 is positioned through theopenings adjacent devices access devices percutaneous access devices access device percutaneous access devices - The spinal fixation element 70 is then moved distally toward the
distal end percutaneous access devices percutaneous access devices spinal anchors - Movement of the spinal fixation element 70 in the distal direction can be achieved using pusher shaft 80, as shown in
FIGS. 10 and 11 . The pusher shaft 80 can have a variety of configurations, but it should be effective to allow controlled movement of the spinal fixation element 70. A person skilled in the art will appreciate that a variety of other techniques can be used to advance the spinal fixation element 70 distally between thepercutaneous access devices spinal anchors - Once the spinal fixation element 70 is fully seated in the receiver heads 52, 52′ of the adjacent
spinal anchors FIG. 11 , the pusher shaft 80, if used, can then be removed or detached from the spinal fixation element 70, and a closure mechanism can be applied to one or both receiver heads 52, 52′ to retain the spinal fixation element 70 therein. In an exemplary embodiment, however, a compression tool 100 is used to compress theaccess devices anchor - An exemplary compression tool 100 is shown in
FIG. 12 , and in general it includes opposed arms 102, 104 that are pivotally coupled to one another at a substantial mid-point thereof such that each arm 102, 104 includes a distal portion 102 b, 104 b that is adapted to be disposed around apercutaneous access device access device distal end device head anchor access devices FIG. 12 . - Once properly positioned, a closure mechanism can be applied, preferably via the
access devices anchor head FIG. 13 illustrates a driver tool 90 disposed throughaccess device 12 for applying a closure mechanism, such as a set screw, to thereceiver head 52 of thespinal anchor 50 to lock the spinal fixation element 70 with respect to thespinal anchor 50. This step can be repeated for the adjacent spinal anchor(s). - A person skilled in the art will appreciate that the spinal fixation element 70 does not need to be directly attached to each
anchor anchors - Once the fixation element 70 is secured in relation to the
implants access devices implants access device - As previously stated, a person skilled in the art will appreciate that the method can be performed in any sequence using any of the steps. Moreover, the access devices of the present invention can be used to deliver multiple spinal fixation elements simultaneously or sequentially, and/or to perform a variety of other surgical procedures not illustrated or described herein.
- One skilled in the art will appreciate further features and advantages of the invention based on the above-described embodiments. Accordingly, the invention is not to be limited by what has been particularly shown and described, except as indicated by the appended claims. All publications and references cited herein are expressly incorporated herein by reference in their entirety.
Claims (17)
1-25. (canceled)
26. A tool set for implanting a spinal rod in a patient; said tool set comprising:
a) a pair of end guide tools;
b) each of said end guide tool being adapted to attach at a lower end thereof to a respective spinal implant bone screw; and
c) each of said end guide tools including a longitudinal guide channel extending upwardly from said lower end thereof; each of said channels being sized and shaped to be adapted to receive opposite ends of the rod for operably guiding the rod ends toward respective bone screws.
27. The tool set according to claim 26 wherein said tool set further includes:
a) at least one intermediate guide tool;
b) each of said intermediate guide tools including attachment structure adapted for attachment to a respective bone screw; and
c) each of said intermediate guide tools including a longitudinal pass through slot extending from a bottom thereof upward and being adapted to receive therethrough and guide the rod to a bone screw attached to a respective intermediate guide tool.
28. The tool set according to claim 26 wherein:
a) said longitudinal guide channel is part of an open pathway that extends from near a bottom of a respective end guide tool to a top thereof; said pathway opening radially outward along the entire length thereof.
29. The tool set according to claim 28 wherein:
a) each said end guide tool has a cutout region between said longitudinal guide channel and said guide tool lower end; said cutout being open in the rear so as to define a pass through slot sized and shaped to be adapted to allow passage therethrough of one end of the rod after the rod has been guided to near a bone screw by said channel.
30. A bone screw and rod seating assembly comprising:
a) a bone screw having a shank for implanting in a bone and a head with a channel adapted to receive a rod;
b) said bone screw head including a first attachment structure thereon;
c) an elongate guide tool having a radially outward facing channel extending parallel to an axis thereof and upwardly from near a bottom of said guide tool; said channel sized and shaped to receive a first end of a rod and operably guide said rod first end to said bone screw head; said guide tool being sized to partially extend above a patient's skin so as to allow percutaneous manipulation of said guide tool by a surgeon; and
d) said guide tool bottom including a second attachment structure thereon; said first and second attachment structures being mateable to releaseably secure said guide tool to said bone screw head.
31. A bone screw and rod seating assembly comprising:
a) a bone screw having a shank for implanting in a bone and a head with channel adapted to receive a rod;
b) said bone screw head including a first attachment structure thereon;
c) an elongate guide tool having a radially pass through slot extending upwardly from near a bottom thereof; said slot being sized and shaped to receive a rod therethrough and operably guide said rod to said bone screw head; said guide tool being sized to partially extend above a patient's skin so as to allow percutaneous manipulation of said guide tool by a surgeon; and
d) said guide tool bottom including a second attachment structure thereon; said first and second attachment structures being mateable to releaseably secure said guide tool to said bone screw head.
32. A tool set for implanting a spinal rod in a patient; said tool set comprising:
a) a pair of end guide tools;
b) each of said end guide tools being adapted to attach at a lower end thereof to a respective spinal implant bone screw; and
c) each of said end guide tools including a longitudinal guide channel extending upwardly from said lower end thereof; each of said channels being sized and shaped to be adapted to receive opposite ends of the rod for operably guiding the rod ends toward respective bone screws.
33. The tool set according to claim 32 wherein said tool set further includes:
a) at least one intermediate guide tool;
b) each of said intermediate guide tools including attachment structure adapted for attachment to a respective bone screw; and
c) each of said intermediate guide tools including a longitudinal pass through slot extending from a bottom thereof upward and being adapted to receive therethrough and guide the rod to a bone screw attached to a respective intermediate guide tool.
34. A bone screw and rod seating assembly comprising:
a) a bone screw having a shank for implanting in a bone and a head with a channel adapted to receive a rod;
b) said bone screw head including a first attachment structure thereon;
c) an elongate guide tool having a radially outward facing channel extending parallel to an axis thereof and upwardly from near a bottom of said guide tool; said channel sized and shaped to receive a first end of a rod and operably guide said rod first end to said bone screw head; said guide tool being sized to partially extend above a patient's skin so as to allow percutaneous manipulation of said guide tool by a surgeon; and
d) said guide tool bottom including a second attachment structure thereon; said first and second attachment structures being mateable to releaseably secure said guide tool to said bone screw head.
35. A bone screw and rod seating assembly comprising:
a) a bone screw having a shank for implanting in a bone and a head with channel adapted to receive a rod;
b) said bone screw head including a first attachment structure thereon;
c) an elongate guide tool having a radially pass through slot extending upwardly from near a bottom thereof; said slot being sized and shaped to receive a rod therethrough and operably guide said rod to said bone screw head; said guide tool being sized to partially extend above a patient's skin so as to allow percutaneous manipulation of said guide tool by a surgeon; and
d) said guide tool bottom including a second attachment structure thereon; said first and second attachment structures being mateable to releaseably secure said guide tool to said bone screw head.
36. A tool for implanting spinal implants in a patient; said tool comprising:
a) said tool being adapted to attach at a lower end thereof to a first spinal implant; and
b) said tool including a radially outwardly opening and longitudinal guide channel extending the entire length thereof; said channel being sized and shaped to be adapted to receive an end of a rod like second implant for operably guiding the second implant toward said first implant.
37. The tool according to claim 36 including:
a) a lower portion that is sized and shaped to be located beneath a patient's skin during use and an upper portion located outside of the patient during use; and b) said lower portion having attachment structure thereon adapted to removably attach said tool to said first implant.
38. The tool according to claim 38 in combination with said first implant.
39. The tool and implant combination according to claim 38 wherein:
a) said first implant is a bone screw.
40. The tool and implant according to claim 38 wherein:
a) said first implant is a hook.
41. The tool and implant combination according to claim 38 wherein:
a) said bone screw has an upper head with a rod receiving channel therein;
b) said attachment structure being configured to attach said tool to said head such that said tool longitudinal channel aligns with said head rod receiving channel, such that a rod received in said tool channel is guided downwardly by said tool to be received in said head tool receiving channel.
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US7666188B2 (en) | 2010-02-23 |
US20050131422A1 (en) | 2005-06-16 |
US20140222083A1 (en) | 2014-08-07 |
US20160045233A1 (en) | 2016-02-18 |
US9216040B2 (en) | 2015-12-22 |
US10413338B2 (en) | 2019-09-17 |
US20100137915A1 (en) | 2010-06-03 |
US8523916B2 (en) | 2013-09-03 |
US20130317552A1 (en) | 2013-11-28 |
US20180125541A1 (en) | 2018-05-10 |
US8721692B2 (en) | 2014-05-13 |
US9888947B2 (en) | 2018-02-13 |
US20190374264A1 (en) | 2019-12-12 |
US11241262B2 (en) | 2022-02-08 |
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