US20080255601A1 - Apparatus and method for remote deflation of intragastric balloon - Google Patents

Apparatus and method for remote deflation of intragastric balloon Download PDF

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Publication number
US20080255601A1
US20080255601A1 US11/735,194 US73519407A US2008255601A1 US 20080255601 A1 US20080255601 A1 US 20080255601A1 US 73519407 A US73519407 A US 73519407A US 2008255601 A1 US2008255601 A1 US 2008255601A1
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US
United States
Prior art keywords
balloon
valve
intragastric balloon
shape memory
deflation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/735,194
Inventor
Janel A. Birk
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Allergan Inc
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Allergan Inc
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Filing date
Publication date
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Priority to US11/735,194 priority Critical patent/US20080255601A1/en
Assigned to ALLERGAN, INC. reassignment ALLERGAN, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BIRK, JANEL A.
Priority to EP08745382A priority patent/EP2139439B1/en
Priority to BRPI0810639A priority patent/BRPI0810639A2/en
Priority to CN200880019831A priority patent/CN101677868A/en
Priority to MX2009011021A priority patent/MX2009011021A/en
Priority to ES08745382T priority patent/ES2370929T3/en
Priority to CA2683715A priority patent/CA2683715C/en
Priority to KR1020097023350A priority patent/KR20100016353A/en
Priority to AU2008239896A priority patent/AU2008239896A1/en
Priority to JP2010503182A priority patent/JP2010523280A/en
Priority to AT08745382T priority patent/ATE522191T1/en
Priority to PCT/US2008/059766 priority patent/WO2008127941A2/en
Publication of US20080255601A1 publication Critical patent/US20080255601A1/en
Priority to US12/698,906 priority patent/US9173757B2/en
Priority to HK10104435.3A priority patent/HK1136482A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/003Implantable devices or invasive measures inflatable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/0036Intragastrical devices
    • A61F5/004Intragastrical devices remotely adjustable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol

Definitions

  • the present invention is directed to devices and methods that enable remote deflation of intragastric balloons used for the treatment of obesity, and in particular devices and methods that enable an implanted intragastric balloon to be remotely deflated while the device itself is in the stomach.
  • Intragastric balloons are well known in the art as a means for treating obesity.
  • One such inflatable intragastric balloon is described in U.S. Pat. No. 5,084,061 and is commercially available as the BioEnterics Intragastric Balloon System (sold under the trademark BIB®). These devices are designed to provide therapy for moderately obese individuals who need to shed pounds in preparation for surgery, or as part of a dietary or behavioral modification program.
  • the BIB System for example, consists of a silicone elastomer intragastric balloon that is inserted into the stomach and filled with fluid.
  • Commercially available intragastric balloons are filled with saline solution or air.
  • the intragastric balloon functions by filling the stomach and enhancing appetite control.
  • Placement of the intragastric balloon is non-surgical, usually requiring no more than 20-30 minutes. The procedure is performed gastroscopically in an outpatient setting, typically using local anesthesia and sedation. Placement is temporary, and intragastric balloons are typically removed after six months.
  • intragastric balloons utilized for this purpose are placed in the stomach in an empty or deflated state and thereafter filled (fully or partially) with a suitable fluid.
  • the balloon occupies space in the stomach, thereby leaving less room available for food and creating a feeling of satiety for the patient.
  • Clinical results with these devices show that for many obese patients, the intragastric balloons significantly help to control appetite and accomplish weight loss.
  • Intragastric balloons typically are implanted for a finite period of time, usually lasting approximately six months. This time period may be shortened by a treating physician who wishes to alter the patient's treatment and remove the balloon prior to the six month period. In any event, at some point after the balloon has been surgically placed in the stomach, it will become desirable to remove the balloon from the stomach.
  • One of the means of removing the balloon is to deflate it by puncturing the balloon, and either aspirating the contents of the balloon or allowing the fluid to pass into the patient's stomach. This means of removing saline from the balloon requires surgical intervention, through the use of a gastroscopic instrument. When the balloon is deflated in this manner, the balloon itself may be surgically removed using the gastroscopic instrument.
  • the acids present in a patient's stomach may erode the balloon to the point where it self-deflates.
  • the deflated balloon may pass naturally through the patient's digestive system and be expelled through the bowel.
  • the present invention is directed at overcoming the problems associated with the prior art systems.
  • the present invention addresses the above-described problems by providing apparatuses and methods for the remote deflation of an intragastric balloon.
  • the present invention allows a physician to remotely deflate an intragastric balloon from outside the body, utilizing a remote control that triggers the deflation with an activation signal.
  • the apparatus of the present invention includes a meltable wax plug that melts to cause the opening of a valve.
  • the microelectronics contained in the valve assembly Upon receipt of an activation signal sent by the physician from a remote control outside the body, the microelectronics contained in the valve assembly cause the temperature of heating element(s) contained within the valve to melt the wax plug. Once the wax plug has melted, thus causing the balloon valve to open, the normal movements of the stomach cause the fluid contained within the balloon to empty from the balloon, causing deflation. The patient is able to then pass the balloon.
  • the apparatus of the present invention includes a remote deflation valve having a shape memory element spring that holds a plug in place, thus sealing the valve of the intragastric balloon.
  • the shape memory element spring may be heated remotely by induction, or the deflation mechanism may include microelectronics to cause heating of the spring.
  • the deflation mechanism may include microelectronics to cause heating of the spring.
  • the spring changes shape as a result of the application of heat, it removes the plug, thus causing the balloon to unseal.
  • the fluid contained in the balloon may then flow freely out of the balloon, thus causing the balloon to deflate.
  • the patient is then able to safely pass the deflated balloon.
  • the intragastric balloon includes a remote deflation mechanism with a shape memory element actuator, a spring collar, an obstruction that holds the spring collar in place and a slit valve.
  • the shape memory element actuator may be heated remotely by induction or may alternatively include microelectronics and heating elements contained within the deflation mechanism.
  • the deflation mechanism When the deflation mechanism is activated, the actuator pushes the obstruction out of the valve, thus allowing the spring collar to contract. The contraction of the spring collar causes the slit valve to open, which allows fluid contained in the balloon to flow out of the balloon and drain accordingly. The patient is then able to pass the deflated balloon.
  • a shape memory element “cutting wire” is employed in the remote deflation mechanism.
  • the wire when heat is applied to the shape memory alloy wire contained within a remote deflation valve, the wire changes shape, causing the wire to cut through a wax (or other suitable material, e.g. plastic or polymer) plug that seals the valve. Once the wax plug has been cut from the valve, fluid is able to freely flow through the valve, thus allowing the balloon to drain and pass from the body.
  • the remote deflation mechanism of the intragastric balloon includes a wire that surrounds the valve.
  • the wire is used to break the bond between the valve and the balloon. When the bond between balloon and the valve is broken, the valve separates from the balloon, and fluid flows freely from the balloon.
  • This preferred embodiment has the added benefit that the balloon and valve assembly may pass through the body separately, thus allowing passage to occur more easily, as the device is in two separate pieces.
  • the valve could be contained in a cylindrical capsule (taking the shape of a large pill, for example) that fits within a collared opening of the balloon shell to create a seal.
  • the collared opening could include a spring or other such mechanism that would retain the size and shape of the collar.
  • the remote deflation mechanism When the remote deflation mechanism is activated, the spring is released, thereby opening the collar and ejecting the cylindrical capsule from the balloon, rendering two separate components that could then easily pass through the gastrointestinal track.
  • the collared opening could include a heating element, which when the remote deflation mechanism is activated, would cause the seal between the capsule and the collar to break, thereby ejecting the cylindrical capsule from the balloon.
  • the cylindrical capsule could contain a mechanism such as a spring (a torsional spring, for example), that retains the shape and size of the capsule, holding the capsule in place within the collared opening of the balloon shell.
  • a spring a torsional spring, for example
  • FIG. 1 is an elevated side view of an intragastric balloon of the present invention.
  • FIG. 2 a is a side cut-away view of a remote deflation valve according to one embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 2 b is a side cut-away view of the remote deflation valve of FIG. 2 a shown in the “open” position.
  • FIG. 3 a is a side cut-away view of a remote deflation valve according to a further embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 3 b is a side cut-away view of the remote deflation valve of FIG. 3 a shown in the “open” position.
  • FIG. 4 a is a side view of a remote deflation valve according to yet a further embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 4 b is a side cut-away view of the remote deflation valve of FIG. 4 a shown in the “open” position.
  • FIG. 5 a is a side view of the remote deflation valve of FIG. 4 a which shows the valve in the “closed” position.
  • FIG. 5 b is a side view of the remote deflation valve of FIG. 4 b shown in the “open” position.
  • FIG. 6 a is a side cut-away view of a remote deflation valve according to still a further embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 6 b is a side cut-away view of the remote deflation valve of FIG. 6 a shown in the “open” position.
  • FIGS. 7 a and 7 b show a top view of an embodiment of the wire cutting mechanism of the remote deflation valve of FIGS. 6 a and 6 b.
  • FIGS. 7 c and 7 d show a further embodiment of the wire cutting mechanism of the remote deflation valve of FIGS. 6 a and 6 b.
  • FIG. 8 a shows an elevated side view of an intragastric balloon of the present invention with a deflation mechanism surrounding the valve prior to the deflation mechanism being activated.
  • FIG. 8 b shows an elevated side view of FIG. 8 a after the deflation mechanism has been activated.
  • FIG. 9 is a front view of a remote control for activating a remote deflation valve according to the present invention.
  • FIG. 10 a is a side cut-away view of a remote-deflating intragastric balloon according to still a further embodiment of the present invention, which shows the balloon in the “closed” position.
  • FIG. 10 b is a side cut-away view of the remote-deflating intragastric balloon of FIG. 10 a shown in the “open” position.
  • FIG. 11 is a side cut-away view of a remote-deflating intragastric balloon according to still a further embodiment of the present invention, which shows the balloon in the “closed” position.
  • the present invention is directed to a method and device for remotely deflating an intragastric balloon without requiring surgical intervention.
  • the intragastric balloon 10 includes a shell 12 , fill valve 14 , and remote deflation valve 16 .
  • an un-inflated balloon 10 may be positioned in the stomach in a desired location. Once the balloon is positioned, it may be inflated using fill valve 14 , and those experienced in the art will appreciate that there are several different methods for inflating the balloon, such as disclosed in commonly assigned International Application Number PCT U.S. 03/19414, entitled “Two Way Slit Valve”, the disclosure of which is incorporated in its entirety herein by reference.
  • the balloon After implantation, it may become desirable to remove the balloon. In order to remove the balloon it must first be deflated. Once deflated, the balloon may be allowed to naturally pass through the body upon deflation, or alternatively the balloon may be surgically removed using a minimally invasive gastroscopic procedure.
  • the present invention is designed such that the deflated intragastric balloon and integrated remote deflation valve may naturally pass through the human body.
  • Remote deflation valve 16 is comprised of sealing plug 30 , heating element(s) 31 , microelectronic control 32 and power source 33 .
  • the power source 33 may be a battery, capacitor, induction coil, kinetic energy creation by body motion stored onto a capacitor, fuel cell, power source powered by chemistry of the body, or a power source powered by temperature change.
  • the sealing plug 30 is preferably formed of suitable medical-grade wax, such as paraffin, or may also be a lower temperature melt polymer. Any type of suitable medical-grade wax, such as paraffin, may be used for sealing plug 30 .
  • the patient may be brought into the physician's office in an outpatient setting.
  • the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 such as that depicted in FIG. 9 .
  • the physician holds remote control 100 near the stomach of the patient, and upon depression of button 101 , remote control 100 sends an activation signal, which my be comprised of radio waves, sonic waves, or any other waves suitable for transmitting a small activation signal through the tissue of the abdominal cavity to the implanted balloon.
  • Microelectronic control 32 has an antenna (not shown) for receiving the activation signal from remote control 100 . Upon receiving the activation signal, microelectronic control uses power from power source 33 to begin increasing the temperature of the heating element(s) 31 .
  • a metal film heating element utilizing metals (such as nichrome, stainless steel, copper, gold, etc.) can be used for heating element(s) 31 .
  • the sealing plug 30 begins to melt. Ideally, the melting point of the sealing plug will be slightly above the temperatures in the stomach to ensure that the valve stays closed in its normal operating environment.
  • wicking surfaces 34 which may be composed of a contoured reservoir. Ideally the wax will melt and be expelled into the stomach for rapid quench cooling and passage through the intestines. The collection of the wax or other sealing material on wicking surfaces 34 prevents it from clogging capillaries 35 and allows the fluid contained within intragastric balloon 10 to flow out of the balloon. Once the sealing plug is completely melted and been expelled into the stomach and/or collected on wicking surfaces 34 , capillaries 35 allow the free flow of the fluid contained inside the balloon through valve opening 36 ( FIG. 2 b ).
  • the balloon will drain of the fluid contained inside and shrink down to a size that is passable through the body.
  • the microelectronics, heating element, and power source are safely contained within the valve structure such that they do not present any danger to the patient.
  • the microelectronic control 32 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • Remote deflation valve 26 is comprised of a shape memory spring 41 , plug 42 , and capillaries 43 . While NiTiNOL is the preferred material for the spring utilized in the present invention, any number of shape memory alloys or polymers, or spring materials, including steels (such as stainless steel, chromium, titanium, etc.), may be used.
  • the patient may be brought into the physician's office in an outpatient setting.
  • the physician activates the deflation mechanism from outside the body, using a remote control (not shown).
  • the spring may be heated remotely by induction from the remote control, or may alternatively include microelectronics for receiving an activation signal and controlling heating elements similar to those described in the previous embodiment.
  • FIG. 3 b shows the valve mechanism in its open position. Because of pressure normally exerted on the balloon by the stomach, the fluid contained therein will flow freely through the capillaries and open channel and into the stomach, thus causing the balloon to deflate. The deflated intragastric balloon is then allowed to pass out of the body.
  • the spring may be detachably fixed to a plug comprised of wax or some other similar biodegradable material. In this way, when the spring is heated and changes shape, it may be used to eject the biodegradable plug into the stomach, thus allowing the balloon to drain. The deflated intragastric balloon would then be allowed to pass out of the body.
  • FIGS. 4 a , 4 b , 5 a , and 5 b another preferred embodiment of a remote deflation valve of the present invention is shown.
  • FIGS. 4 a and 4 b show a cutaway side view of remote deflation valve 56
  • FIGS. 5 a and 5 b show the same valve in a side view.
  • Remote deflation valve 56 is comprised of a shape memory actuator 61 , obstruction 62 , slit valve 63 and spring collar 64 .
  • NiTiNOL is the preferred material for the actuator of the present invention, any number of shape memory alloys or polymers may be used.
  • the physician activates the valve opening mechanism remotely and from outside the body, using remote control 100 .
  • the actuator 61 may be heated remotely by induction or alternatively the remote deflation valve may include microelectronics and heating elements.
  • the actuator 61 when activated, pushes obstruction 62 out of the valve opening.
  • obstruction 62 serves to prevent the slit valve 63 from opening by causing spring collar 64 to be held in its open position, as shown in FIGS. 4 a and 5 a .
  • spring collar 64 which is located below the slit valve 63 , contracts. The contraction of spring collar 64 causes the slit valve 63 to be opened, as shown in FIG. 4 b and 5 b . With the slit valve 63 now open, the fluid contained in the balloon may flow through channel 65 and out through the slit valve opening 66 .
  • the intragastric balloon is under pressure, and due to the normal movements of the stomach, the fluid contained therein will flow freely through open slit valve 63 and into the stomach, thus causing the balloon to deflate. The deflated intragastric balloon is then allowed to pass out of the body.
  • Remote deflation valve 76 is comprised of a shape memory alloy cutting wire mechanism 81 , sealing plug 82 , and capillary 83 .
  • NiTiNOL is used in this preferred embodiment, however, any number of suitable shape memory alloys may be used.
  • the physician activates the valve opening mechanism remotely and from outside the body, using remote control 100 ( FIG. 9 ).
  • the remote deflation valve 76 includes microelectronics (not shown), a battery or other power source (not shown) and heating element(s) 85 ( FIGS. 7 a - 7 d ) for heating the shape memory alloy cutting wire 84 ( FIGS. 7 a - 7 d ).
  • the shape memory alloy cutting wire may be heated by induction.
  • FIGS. 7 a , 7 b , 7 c , and 7 d show top views of the cutting wire mechanism 84 .
  • the shape memory element begins to change shape.
  • FIG. 7 a shows the shape memory element cutting wire 84 prior to the application of heat.
  • the shape memory element cutting wire 84 Prior to the application of heat, the shape memory element cutting wire 84 is in a curved L-shape, with the curved portion resting around the outside of wax plug 82 .
  • the cutting wire may also be in a loop shape that completely encircles the wax plug, as is shown in FIG. 7 c.
  • the shape memory element cutting wire mechanism 81 is activated by a signal received from remote control 100 ( FIG. 9 ). Upon receiving the activation signal, the microelectronic control (not shown) uses power from the power source (not shown) to begin increasing the temperature of heating element(s) 85 . As the shape memory element cutting wire 84 begins to change shape as a result of the application of heat, it slices through the sealing plug 82 .
  • FIGS. 7 b and 7 d show the shape memory alloy cutting wire 84 in its post-heat application deformed shape, having cut through the sealing plug 82 .
  • FIG. 7 a shows a shape memory alloy cutting wire in an L-shaped configuration
  • FIG. 7 c shows a shape memory alloy cutting wire in a loop shaped configuration.
  • the capillary 83 ( FIG. 6 b ) is now open to allow fluid contained within the intragastric balloon to escape the balloon. Again, because the intragastric balloon is under pressure and due to the normal movements of the stomach, the fluid contained in the balloon will flow freely through the capillary and into the stomach, thus causing the balloon to deflate. The deflated intragastric balloon is then allowed to pass out of the body.
  • Intragastric balloon 90 is comprised of shell 97 , valve 91 , valve/balloon bond 92 , heating elements 93 , cutting wire 94 , microelectronic control 95 , and power source 96 .
  • FIGS. 8 a and 8 b utilizes a deflation mechanism for separating the entire valve from the remaining portion of the balloon.
  • the patient may be brought into the physician's office in an outpatient setting.
  • the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 ( FIG. 9 ).
  • the physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal to the microelectronic control 95 .
  • Microelectronic control 95 has an antenna (not shown) for receiving the activation signal from remote control 100 .
  • microelectronic control uses power from power source 96 to begin increasing the temperature of heating element(s) 93 .
  • metal film heating elements utilizing materials such as nichrome, stainless steel, copper, gold, or other such materials, can be used for heating element(s) 93 .
  • the temperature of cutting wire 94 also begins to increase. The increased temperature of the cutting wire causes the valve/balloon bond 92 to deteriorate, resulting in separation of the valve 91 from shell 97 .
  • valve/balloon bond 92 Once the valve/balloon bond 92 is broken and the valve is separated from the shell, fluid contained inside the balloon freely flows through the opening 98 that is created by the separation of the two portions. Through the normal movements and contraction of the stomach walls, the balloon will drain of the fluid contained inside and shrink down to a size that is passable through the human body. The microelectronics, heating element(s) and power source are safely contained within the valve structure such that they do not present any danger to the patient. Because the entire intragastric balloon may now be in two separate pieces—an empty shell and a self-contained valve assembly—the passing of the balloon and valve is facilitated.
  • the microelectronic control 95 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • FIGS. 10 a and 10 b another preferred embodiment of an intragastric balloon of the present invention incorporating a remote deflation mechanism is shown.
  • Intragastric balloon 109 is comprised of shell 110 and valve capsule 111 .
  • Valve capsule 111 is comprised of valve 112 , shape memory torsional spring 113 , and combined microelectronic control and power source 115 .
  • FIG. 10 a also shows adjustment tool 121 for adjusting the volume of the intragastric balloon 109 .
  • FIGS. 10 a and 10 b utilizes a deflation mechanism for separating the entire valve capsule from the remaining portion of the balloon.
  • the valve capsule 111 When inflated, the valve capsule 111 is held tightly in the balloon collar 114 by pressure exerted by shape memory torsional spring 113 , creating a seal between the valve capsule and the balloon collar.
  • the patient may be brought into the physician's office in an outpatient setting.
  • the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 ( FIG. 9 ).
  • the physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal to the combined microelectronic control and power source 115 .
  • Combined microelectronic control and power supply 115 has an antenna (not shown) for receiving the activation signal from remote control 100 .
  • combined microelectronic control and power source uses power to begin increasing the temperature of heating element(s) (not shown) that are connected to the torsional spring 113 .
  • metal film heating elements utilizing materials such as nichrome, stainless steel, copper, gold, or other such materials, can be used for the heating element(s).
  • the temperature of shape memory torsional spring 113 also begins to increase, thereby causing the spring to deform and reduce in diameter. As the diameter decreases, the seal between valve capsule 111 and balloon collar 114 is broken.
  • the combined microelectronic control and power supply 115 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • FIG. 11 another preferred embodiment of an intragastric balloon of the present invention incorporating a remote deflation mechanism is shown.
  • Intragastric balloon 129 is comprised of shell 130 and valve capsule 131 .
  • Valve capsule 131 is comprised of valve 132 , and combined microelectronic control and power source 135 .
  • Shell 130 is comprised of a collar 136 , heating element 137 , and shape memory cutting element 138 .
  • FIG. 11 also shows adjustment tool 141 for adjusting the volume of the intragastric balloon 129 .
  • the embodiment of the present invention shown in FIG. 11 utilizes a deflation mechanism for separating the entire valve capsule from the remaining portion of the balloon.
  • the valve capsule 131 When inflated, the valve capsule 131 is held tightly in the balloon collar 114 by pressure exerted by shape memory element 138 , creating a seal between the valve capsule and the balloon collar.
  • the patient may be brought into the physician's office in an outpatient setting.
  • the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 ( FIG. 9 ).
  • the physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal to the combined microelectronic control and power source 135 .
  • Combined microelectronic control and power supply 135 has an antenna (not shown) for receiving the activation signal from remote control 100 .
  • combined microelectronic control and power source uses power to begin increasing the temperature of heating element(s) 137 that are connected to the shape memory cutting element 138 .
  • metal film heating elements utilizing materials such as nichrome, stainless steel, copper, gold, or other such materials, can be used for the heating element(s).
  • the temperature of shape memory cutting element 138 also begins to increase, thereby causing the cutting element to cut through the balloon collar 136 . With the balloon collar 136 completely cut, the seal between valve capsule 131 and balloon collar 136 is broken.
  • the remote deflation mechanism may be comprised of a mechanical system (such as a torsional spring) contained within the collar which holds the valve capsule in place until the balloon deflation mechanism is initiated.
  • the combined microelectronic control and power supply 135 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • the intragastric balloon of the present invention may be constructed of a very thin, highly acid-resistant shell material.
  • the intragastric balloon may be shaped to encourage collapse into a bullet shape for smooth passage through the intestines. This shape may be created by pre-formed convolutions in the shell that would expand into a substantially spherical or ellipsoidal shape when inflated, but would retract into its small collapsed shape when the remote deflation mechanism was triggered.
  • the remote control will take the form of a handheld control unit that may feature an LCD display and/or similar type of display and a control panel, such as a keyboard or touchscreen, to operate the device.
  • the remote control may feature a series of menus that allow an operator to program (or read/determine) the microelectronics to contain in memory important information such as the intragastric balloon's size, patient's name, implanting physician, and the date it was implanted.
  • the remote control may communicate with the sensor via telemetry through radiowaves.
  • the FDA and globally recognized communications band may be used in some embodiments, and an authentication process (e.g., digital handshake signal, PIN verification, or other similar verification process) can be used to ensure that the device cannot be accidentally accessed or controlled by another control mechanism other than the remote control.
  • the telemetry control signal can be sent from approximately a foot or possibly a greater distance from the patient and will typically not require the patient to disrobe to query the sensor or to change its parameters.
  • the remote control is preferably able to read and write information to the microelectronics contained in the intragastric balloon.
  • the remote control may also be password controlled to prevent unauthorized personnel from querying the device.
  • the display of the remote control which may include visual and audio outputs, typically will display or output the sensed parameter of the remote deflation valve's condition or physical parameter whether this parameter is “open”, “closed”, or any other physical parameter that the remote control is adjusted to monitor.
  • the patient is an overweight male who has previously had an intragastric balloon inserted into his stomach.
  • the intragastric balloon has been implanted for a full course of treatment for six months, and the surgeon is prepared to remove the balloon.
  • the removal of the balloon is performed in an outpatient setting at the doctor's office. Reference is made to FIGS. 2 a and 2 b for the remote deflation valve utilized in this example.
  • the physician activates the remote deflation mechanism from outside the body using a remote control 100 , such as that depicted in FIG. 9 .
  • the physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal through the patient's tissue to the microelectronic control 32 .
  • microelectronic control 32 Upon receiving the activation signal, microelectronic control 32 uses power from a battery 33 to begin increasing the temperature of heating element(s) 31 . As the temperature of heating element(s) 31 begins to increase, the wax plug 30 begins to melt.
  • wicking surfaces 34 As the wax begins to melt, it collects on wicking surfaces 34 . The collection of the wax on wicking surfaces 34 prevents the wax from clogging capillaries 35 and allows the fluid contained within intragastric balloon 10 to flow out of the balloon. Once the wax is melted and collected on wicking surfaces 34 , capillaries 35 allow the free flow of the fluid contained inside the balloon through valve opening 36 . In addition, once the wax is melted, the microelectronic control 32 sends a confirmation signal to the remote control 100 , informing the doctor and patient that the deflation device has been activated.
  • the balloon drains of the saline contained inside and shrinks down to a size that is passable through the human body.
  • the microelectronics, heating elements, and battery are safely contained within the valve structure such that they do not present any danger to the patient.
  • the patient may now leave the doctor's office and return home.
  • the patient tracks the passage of the intragastric balloon and informs the doctor when it has passed.
  • the patient is an overweight female who has previously had an intragastric balloon implanted. After implantation the patient has experienced significant undesired side effects resulting from the implantation, including nausea, vomiting, and general abdominal discomfort. Therefore, the patient desires to have the remote deflation mechanism activated, thus allowing the balloon to be passed.
  • the balloon removal is performed in an outpatient setting at the doctor's office.
  • the physician activates the remote deflation mechanism using a remote control 100 , such as that depicted in FIG. 9 .
  • the physician positions remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal through the tissue of the abdominal cavity to the microelectronic control 95 .
  • Microelectronic control 95 has an antenna for receiving the activation signal from remote control 100 . Upon receiving the activation signal, microelectronic control uses power from battery 96 to begin increasing the temperature of heating element(s) 93 . As the temperature of heating element(s) 93 begins to increase, the temperature of cutting wire 94 also begins to increase. The increased temperature of the cutting wire causes the valve/balloon bond 92 to deteriorate, resulting in separation of the valve 91 from shell 97 .
  • the normal movements of the stomach cause the fluid contained inside the balloon to freely flow through the opening 98 .
  • the normal movements and contraction of the stomach walls cause the intragastric balloon to completely drain of the fluid contained inside and shrink down to a size that is passable through the human body.
  • the microelectronics, heating elements and battery are safely contained within the valve structure such that they do not present any danger to the patient. Because the entire intragastric balloon may now comprise two separate pieces, the passing of the balloon and valve is facilitated.
  • the microelectronic control 95 sends a confirmation signal to remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal by the remote control, the procedure is complete and the patient can return home and wait until the shell and valve assembly pass through the system. The patient tracks the passage of the intragastric balloon and informs the doctor when its has passed.
  • the patient is an overweight male who has previously had an intragastric balloon inserted into his stomach.
  • the intragastric balloon has been implanted for a full course of treatment for six months, and the surgeon is prepared to remove the balloon.
  • FIGS. 10 a and 10 b for the remote deflation valve utilized in this example.
  • the physician activates the remote deflation mechanism from outside the body using a remote control 100 , such as that depicted in FIG. 9 .
  • the physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal through the patient's tissue to the combined microelectronic control and power source 115 .
  • the combined microelectronic control and power source 115 uses power to begin increasing the temperature of heating element(s) (not shown) that are connected to the torsional spring 113 .
  • the temperature of the heating element(s) begin to increase, the temperature of shape memory torsional spring 113 also begins to increase, thereby causing the spring to deform and reduce in diameter.
  • the seal between valve capsule 111 and balloon collar 114 is broken. The valve capsule is separated from the shell, and fluid contained inside the balloon freely flows through the opening 116 ( FIG. 10 b ) that is created by the separation of the two portions.
  • the balloon drains of the saline contained inside and shrinks down to a size that is passable through the human body.
  • the combined microelectronics control and power supply and heating element(s) are safely contained within the valve capsule such that they do not present any danger to the patient.
  • the patient may now leave the doctor's office and return home.
  • the patient tracks the passage of the intragastric balloon and informs the doctor when it has passed.

Abstract

An intragastric balloon and apparatus for remote deflation of the balloon are disclosed. The apparatus for remote deflation allows the physician to cause the valve of the intragastric balloon to open without surgery using a remote control from outside of the body. The remote deflation mechanism may be powered internally by a battery or may be powered externally by induction. Additionally, a deflation mechanism that causes the entire valve to be separated from the intragastric balloon is disclosed.

Description

    BACKGROUND OF INVENTION
  • 1. Field of the Invention
  • The present invention is directed to devices and methods that enable remote deflation of intragastric balloons used for the treatment of obesity, and in particular devices and methods that enable an implanted intragastric balloon to be remotely deflated while the device itself is in the stomach.
  • 2. Description of the Related Art
  • Intragastric balloons are well known in the art as a means for treating obesity. One such inflatable intragastric balloon is described in U.S. Pat. No. 5,084,061 and is commercially available as the BioEnterics Intragastric Balloon System (sold under the trademark BIB®). These devices are designed to provide therapy for moderately obese individuals who need to shed pounds in preparation for surgery, or as part of a dietary or behavioral modification program.
  • The BIB System, for example, consists of a silicone elastomer intragastric balloon that is inserted into the stomach and filled with fluid. Commercially available intragastric balloons are filled with saline solution or air. The intragastric balloon functions by filling the stomach and enhancing appetite control. Placement of the intragastric balloon is non-surgical, usually requiring no more than 20-30 minutes. The procedure is performed gastroscopically in an outpatient setting, typically using local anesthesia and sedation. Placement is temporary, and intragastric balloons are typically removed after six months.
  • Most intragastric balloons utilized for this purpose are placed in the stomach in an empty or deflated state and thereafter filled (fully or partially) with a suitable fluid. The balloon occupies space in the stomach, thereby leaving less room available for food and creating a feeling of satiety for the patient. Clinical results with these devices show that for many obese patients, the intragastric balloons significantly help to control appetite and accomplish weight loss.
  • Intragastric balloons typically are implanted for a finite period of time, usually lasting approximately six months. This time period may be shortened by a treating physician who wishes to alter the patient's treatment and remove the balloon prior to the six month period. In any event, at some point after the balloon has been surgically placed in the stomach, it will become desirable to remove the balloon from the stomach. One of the means of removing the balloon is to deflate it by puncturing the balloon, and either aspirating the contents of the balloon or allowing the fluid to pass into the patient's stomach. This means of removing saline from the balloon requires surgical intervention, through the use of a gastroscopic instrument. When the balloon is deflated in this manner, the balloon itself may be surgically removed using the gastroscopic instrument.
  • Alternatively, if the balloon is left in place beyond its designed lifetime, the acids present in a patient's stomach may erode the balloon to the point where it self-deflates. When this occurs, the deflated balloon may pass naturally through the patient's digestive system and be expelled through the bowel.
  • Those experienced in the art will readily appreciate that manipulating the balloon in situ in order to deflate the balloon can be difficult. This is because the balloon is slippery and positionally unstable. The usually spherical or ellipsoidal intragastric balloons may readily rotate in the stomach, making it difficult for a surgeon to manipulate the balloon in order to find a deflation valve, or to safely puncture the balloon using a surgical instrument.
  • It may become desirable, then, particularly when the balloon is to be removed from the body, to cause the deflation of the balloon remotely without surgical intervention.
  • Therefore, the present invention is directed at overcoming the problems associated with the prior art systems. These and other objects of the present invention will become apparent from the further disclosure to be made in the detailed descriptions given below.
  • SUMMARY OF THE INVENTION
  • The present invention addresses the above-described problems by providing apparatuses and methods for the remote deflation of an intragastric balloon. The present invention allows a physician to remotely deflate an intragastric balloon from outside the body, utilizing a remote control that triggers the deflation with an activation signal.
  • In one preferred embodiment, the apparatus of the present invention includes a meltable wax plug that melts to cause the opening of a valve. Upon receipt of an activation signal sent by the physician from a remote control outside the body, the microelectronics contained in the valve assembly cause the temperature of heating element(s) contained within the valve to melt the wax plug. Once the wax plug has melted, thus causing the balloon valve to open, the normal movements of the stomach cause the fluid contained within the balloon to empty from the balloon, causing deflation. The patient is able to then pass the balloon.
  • In another preferred embodiment, the apparatus of the present invention includes a remote deflation valve having a shape memory element spring that holds a plug in place, thus sealing the valve of the intragastric balloon. The shape memory element spring may be heated remotely by induction, or the deflation mechanism may include microelectronics to cause heating of the spring. As the spring changes shape as a result of the application of heat, it removes the plug, thus causing the balloon to unseal. The fluid contained in the balloon may then flow freely out of the balloon, thus causing the balloon to deflate. The patient is then able to safely pass the deflated balloon.
  • According to yet another embodiment of the present invention, the intragastric balloon includes a remote deflation mechanism with a shape memory element actuator, a spring collar, an obstruction that holds the spring collar in place and a slit valve. As with the other embodiments disclosed, the shape memory element actuator may be heated remotely by induction or may alternatively include microelectronics and heating elements contained within the deflation mechanism. When the deflation mechanism is activated, the actuator pushes the obstruction out of the valve, thus allowing the spring collar to contract. The contraction of the spring collar causes the slit valve to open, which allows fluid contained in the balloon to flow out of the balloon and drain accordingly. The patient is then able to pass the deflated balloon.
  • In another preferred embodiment of the present invention, a shape memory element “cutting wire” is employed in the remote deflation mechanism. In this embodiment, when heat is applied to the shape memory alloy wire contained within a remote deflation valve, the wire changes shape, causing the wire to cut through a wax (or other suitable material, e.g. plastic or polymer) plug that seals the valve. Once the wax plug has been cut from the valve, fluid is able to freely flow through the valve, thus allowing the balloon to drain and pass from the body.
  • In still yet another preferred embodiment of the present invention, the remote deflation mechanism of the intragastric balloon includes a wire that surrounds the valve. The wire is used to break the bond between the valve and the balloon. When the bond between balloon and the valve is broken, the valve separates from the balloon, and fluid flows freely from the balloon. This preferred embodiment has the added benefit that the balloon and valve assembly may pass through the body separately, thus allowing passage to occur more easily, as the device is in two separate pieces. These and various other aspects of the invention, and its advantages, will be discussed in more detail below.
  • In another embodiment, the valve could be contained in a cylindrical capsule (taking the shape of a large pill, for example) that fits within a collared opening of the balloon shell to create a seal. The collared opening could include a spring or other such mechanism that would retain the size and shape of the collar. When the remote deflation mechanism is activated, the spring is released, thereby opening the collar and ejecting the cylindrical capsule from the balloon, rendering two separate components that could then easily pass through the gastrointestinal track. Alternatively, the collared opening could include a heating element, which when the remote deflation mechanism is activated, would cause the seal between the capsule and the collar to break, thereby ejecting the cylindrical capsule from the balloon. As yet a further alternative, the cylindrical capsule could contain a mechanism such as a spring (a torsional spring, for example), that retains the shape and size of the capsule, holding the capsule in place within the collared opening of the balloon shell. When the remote deflation mechanism is activated, the torsional spring collapses, causing the capsule to be ejected from the balloon.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is an elevated side view of an intragastric balloon of the present invention.
  • FIG. 2 a is a side cut-away view of a remote deflation valve according to one embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 2 b is a side cut-away view of the remote deflation valve of FIG. 2 a shown in the “open” position.
  • FIG. 3 a is a side cut-away view of a remote deflation valve according to a further embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 3 b is a side cut-away view of the remote deflation valve of FIG. 3 a shown in the “open” position.
  • FIG. 4 a is a side view of a remote deflation valve according to yet a further embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 4 b is a side cut-away view of the remote deflation valve of FIG. 4 a shown in the “open” position.
  • FIG. 5 a is a side view of the remote deflation valve of FIG. 4 a which shows the valve in the “closed” position.
  • FIG. 5 b is a side view of the remote deflation valve of FIG. 4 b shown in the “open” position.
  • FIG. 6 a is a side cut-away view of a remote deflation valve according to still a further embodiment of the present invention, which shows the valve in the “closed” position.
  • FIG. 6 b is a side cut-away view of the remote deflation valve of FIG. 6 a shown in the “open” position.
  • FIGS. 7 a and 7 b show a top view of an embodiment of the wire cutting mechanism of the remote deflation valve of FIGS. 6 a and 6 b.
  • FIGS. 7 c and 7 d show a further embodiment of the wire cutting mechanism of the remote deflation valve of FIGS. 6 a and 6 b.
  • FIG. 8 a shows an elevated side view of an intragastric balloon of the present invention with a deflation mechanism surrounding the valve prior to the deflation mechanism being activated.
  • FIG. 8 b shows an elevated side view of FIG. 8 a after the deflation mechanism has been activated.
  • FIG. 9 is a front view of a remote control for activating a remote deflation valve according to the present invention.
  • FIG. 10 a is a side cut-away view of a remote-deflating intragastric balloon according to still a further embodiment of the present invention, which shows the balloon in the “closed” position.
  • FIG. 10 b is a side cut-away view of the remote-deflating intragastric balloon of FIG. 10 a shown in the “open” position.
  • FIG. 11 is a side cut-away view of a remote-deflating intragastric balloon according to still a further embodiment of the present invention, which shows the balloon in the “closed” position.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The present invention is directed to a method and device for remotely deflating an intragastric balloon without requiring surgical intervention.
  • Referring to FIGS. 1-2 b, the intragastric balloon according to one preferred embodiment of the present invention is shown. The intragastric balloon 10 includes a shell 12, fill valve 14, and remote deflation valve 16.
  • During implantation, an un-inflated balloon 10 may be positioned in the stomach in a desired location. Once the balloon is positioned, it may be inflated using fill valve 14, and those experienced in the art will appreciate that there are several different methods for inflating the balloon, such as disclosed in commonly assigned International Application Number PCT U.S. 03/19414, entitled “Two Way Slit Valve”, the disclosure of which is incorporated in its entirety herein by reference.
  • After implantation, it may become desirable to remove the balloon. In order to remove the balloon it must first be deflated. Once deflated, the balloon may be allowed to naturally pass through the body upon deflation, or alternatively the balloon may be surgically removed using a minimally invasive gastroscopic procedure. The present invention is designed such that the deflated intragastric balloon and integrated remote deflation valve may naturally pass through the human body.
  • Referring to FIGS. 2 a and 2 b, a preferred embodiment of the remote deflation valve of the present invention is shown. Remote deflation valve 16 is comprised of sealing plug 30, heating element(s) 31, microelectronic control 32 and power source 33. The power source 33 may be a battery, capacitor, induction coil, kinetic energy creation by body motion stored onto a capacitor, fuel cell, power source powered by chemistry of the body, or a power source powered by temperature change. The sealing plug 30 is preferably formed of suitable medical-grade wax, such as paraffin, or may also be a lower temperature melt polymer. Any type of suitable medical-grade wax, such as paraffin, may be used for sealing plug 30.
  • At the time the physician desires to deflate the balloon, the patient may be brought into the physician's office in an outpatient setting. In order to open deflation valve 16, the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 such as that depicted in FIG. 9. The physician holds remote control 100 near the stomach of the patient, and upon depression of button 101, remote control 100 sends an activation signal, which my be comprised of radio waves, sonic waves, or any other waves suitable for transmitting a small activation signal through the tissue of the abdominal cavity to the implanted balloon.
  • Microelectronic control 32 has an antenna (not shown) for receiving the activation signal from remote control 100. Upon receiving the activation signal, microelectronic control uses power from power source 33 to begin increasing the temperature of the heating element(s) 31. A metal film heating element, utilizing metals (such as nichrome, stainless steel, copper, gold, etc.) can be used for heating element(s) 31. As the temperature of the heating element(s) 31 begins to increase, the sealing plug 30 begins to melt. Ideally, the melting point of the sealing plug will be slightly above the temperatures in the stomach to ensure that the valve stays closed in its normal operating environment.
  • As the sealing plug begins to melt, it is expelled into the stomach and/or collects on wicking surfaces 34, which may be composed of a contoured reservoir. Ideally the wax will melt and be expelled into the stomach for rapid quench cooling and passage through the intestines. The collection of the wax or other sealing material on wicking surfaces 34 prevents it from clogging capillaries 35 and allows the fluid contained within intragastric balloon 10 to flow out of the balloon. Once the sealing plug is completely melted and been expelled into the stomach and/or collected on wicking surfaces 34, capillaries 35 allow the free flow of the fluid contained inside the balloon through valve opening 36 (FIG. 2 b). Through the normal movements and contraction of the stomach walls, the balloon will drain of the fluid contained inside and shrink down to a size that is passable through the body. The microelectronics, heating element, and power source are safely contained within the valve structure such that they do not present any danger to the patient.
  • In addition to performing the function of controlling the heating element for the melting of the sealing plug, the microelectronic control 32 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • Referring to FIGS. 3 a and 3 b, another preferred embodiment of the remote deflation valve of the present invention is shown. Remote deflation valve 26 is comprised of a shape memory spring 41, plug 42, and capillaries 43. While NiTiNOL is the preferred material for the spring utilized in the present invention, any number of shape memory alloys or polymers, or spring materials, including steels (such as stainless steel, chromium, titanium, etc.), may be used.
  • As with the valve mechanism discussed in the previous embodiment, at the time the physician desires to deflate the balloon, the patient may be brought into the physician's office in an outpatient setting.
  • In order to open deflation valve 26, the physician activates the deflation mechanism from outside the body, using a remote control (not shown). The spring may be heated remotely by induction from the remote control, or may alternatively include microelectronics for receiving an activation signal and controlling heating elements similar to those described in the previous embodiment.
  • Irrespective of the method of activation, when the spring 41 is heated, it contracts, pulling the plug 42 out of its resting place and into reservoir 44. This causes channel 45 to open, thus allowing the fluid contained in the balloon to flow through the capillaries 43 and open channel 45, out of the balloon. FIG. 3 b shows the valve mechanism in its open position. Because of pressure normally exerted on the balloon by the stomach, the fluid contained therein will flow freely through the capillaries and open channel and into the stomach, thus causing the balloon to deflate. The deflated intragastric balloon is then allowed to pass out of the body.
  • As an alternative to having a shape memory spring permanently fixed to a plug, the spring may be detachably fixed to a plug comprised of wax or some other similar biodegradable material. In this way, when the spring is heated and changes shape, it may be used to eject the biodegradable plug into the stomach, thus allowing the balloon to drain. The deflated intragastric balloon would then be allowed to pass out of the body.
  • Referring to FIGS. 4 a, 4 b, 5 a, and 5 b, another preferred embodiment of a remote deflation valve of the present invention is shown. FIGS. 4 a and 4 b show a cutaway side view of remote deflation valve 56, while FIGS. 5 a and 5 b show the same valve in a side view. Remote deflation valve 56 is comprised of a shape memory actuator 61, obstruction 62, slit valve 63 and spring collar 64. As previously discussed, while NiTiNOL is the preferred material for the actuator of the present invention, any number of shape memory alloys or polymers may be used.
  • In order to open deflation valve 56, the physician activates the valve opening mechanism remotely and from outside the body, using remote control 100. The actuator 61 may be heated remotely by induction or alternatively the remote deflation valve may include microelectronics and heating elements.
  • Irrespective of the method of activation, the actuator 61, when activated, pushes obstruction 62 out of the valve opening. When in place, obstruction 62 serves to prevent the slit valve 63 from opening by causing spring collar 64 to be held in its open position, as shown in FIGS. 4 a and 5 a. Once the obstruction 62 is removed from the valve opening, spring collar 64, which is located below the slit valve 63, contracts. The contraction of spring collar 64 causes the slit valve 63 to be opened, as shown in FIG. 4 b and 5 b. With the slit valve 63 now open, the fluid contained in the balloon may flow through channel 65 and out through the slit valve opening 66. Again, because the intragastric balloon is under pressure, and due to the normal movements of the stomach, the fluid contained therein will flow freely through open slit valve 63 and into the stomach, thus causing the balloon to deflate. The deflated intragastric balloon is then allowed to pass out of the body.
  • Referring to FIGS. 6 a and 6 b, an interior cutaway view of another preferred embodiment of the remote deflation valve of the present invention is shown. Remote deflation valve 76 is comprised of a shape memory alloy cutting wire mechanism 81, sealing plug 82, and capillary 83. NiTiNOL is used in this preferred embodiment, however, any number of suitable shape memory alloys may be used.
  • As with the previous embodiments discussed, in order to open valve 76, the physician activates the valve opening mechanism remotely and from outside the body, using remote control 100 (FIG. 9). In this embodiment, the remote deflation valve 76 includes microelectronics (not shown), a battery or other power source (not shown) and heating element(s) 85 (FIGS. 7 a-7 d) for heating the shape memory alloy cutting wire 84 (FIGS. 7 a-7 d). As with the previous embodiments discussed, however, the shape memory alloy cutting wire may be heated by induction.
  • FIGS. 7 a, 7 b, 7 c, and 7 d show top views of the cutting wire mechanism 84. As heat is applied by the heating elements, the shape memory element begins to change shape. FIG. 7 a shows the shape memory element cutting wire 84 prior to the application of heat. Prior to the application of heat, the shape memory element cutting wire 84 is in a curved L-shape, with the curved portion resting around the outside of wax plug 82. As an alternative to the L-shaped shape memory element cutting wire 84 of FIG. 7 a, the cutting wire may also be in a loop shape that completely encircles the wax plug, as is shown in FIG. 7 c.
  • In this embodiment, the shape memory element cutting wire mechanism 81 is activated by a signal received from remote control 100 (FIG. 9). Upon receiving the activation signal, the microelectronic control (not shown) uses power from the power source (not shown) to begin increasing the temperature of heating element(s) 85. As the shape memory element cutting wire 84 begins to change shape as a result of the application of heat, it slices through the sealing plug 82. FIGS. 7 b and 7 d show the shape memory alloy cutting wire 84 in its post-heat application deformed shape, having cut through the sealing plug 82. FIG. 7 a shows a shape memory alloy cutting wire in an L-shaped configuration, while FIG. 7 c shows a shape memory alloy cutting wire in a loop shaped configuration.
  • With the sealing plug 82 having been severed from the valve, the capillary 83 (FIG. 6 b) is now open to allow fluid contained within the intragastric balloon to escape the balloon. Again, because the intragastric balloon is under pressure and due to the normal movements of the stomach, the fluid contained in the balloon will flow freely through the capillary and into the stomach, thus causing the balloon to deflate. The deflated intragastric balloon is then allowed to pass out of the body.
  • Referring to FIGS. 8 a and 8 b, another preferred embodiment of an intragastric balloon of the present invention incorporating a remote deflation mechanism is shown. Intragastric balloon 90 is comprised of shell 97, valve 91, valve/balloon bond 92, heating elements 93, cutting wire 94, microelectronic control 95, and power source 96.
  • Rather than using a remote deflation mechanism to open the valve of the intragastric balloon, the embodiment of the present invention shown in FIGS. 8 a and 8 b utilizes a deflation mechanism for separating the entire valve from the remaining portion of the balloon.
  • Similar to the procedures described above, at the time the physician desires to deflate the balloon, the patient may be brought into the physician's office in an outpatient setting. In order to cause the intragastric balloon 90 to deflate, the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 (FIG. 9). The physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal to the microelectronic control 95.
  • Microelectronic control 95 has an antenna (not shown) for receiving the activation signal from remote control 100. Upon receiving the activation signal, microelectronic control uses power from power source 96 to begin increasing the temperature of heating element(s) 93. Similar to the embodiments discussed above that incorporate heating elements, metal film heating elements utilizing materials such as nichrome, stainless steel, copper, gold, or other such materials, can be used for heating element(s) 93. As the temperature of heating element(s) 93 begin to increase, the temperature of cutting wire 94 also begins to increase. The increased temperature of the cutting wire causes the valve/balloon bond 92 to deteriorate, resulting in separation of the valve 91 from shell 97.
  • Once the valve/balloon bond 92 is broken and the valve is separated from the shell, fluid contained inside the balloon freely flows through the opening 98 that is created by the separation of the two portions. Through the normal movements and contraction of the stomach walls, the balloon will drain of the fluid contained inside and shrink down to a size that is passable through the human body. The microelectronics, heating element(s) and power source are safely contained within the valve structure such that they do not present any danger to the patient. Because the entire intragastric balloon may now be in two separate pieces—an empty shell and a self-contained valve assembly—the passing of the balloon and valve is facilitated.
  • As with the previous embodiments described, in addition to performing the function of controlling the heating elements, the microelectronic control 95 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • Referring to FIGS. 10 a and 10 b, another preferred embodiment of an intragastric balloon of the present invention incorporating a remote deflation mechanism is shown. Intragastric balloon 109 is comprised of shell 110 and valve capsule 111. Valve capsule 111 is comprised of valve 112, shape memory torsional spring 113, and combined microelectronic control and power source 115. FIG. 10 a also shows adjustment tool 121 for adjusting the volume of the intragastric balloon 109.
  • Rather than using a remote deflation mechanism to open the valve of the intragastric balloon, the embodiment of the present invention shown in FIGS. 10 a and 10 b utilizes a deflation mechanism for separating the entire valve capsule from the remaining portion of the balloon. When inflated, the valve capsule 111 is held tightly in the balloon collar 114 by pressure exerted by shape memory torsional spring 113, creating a seal between the valve capsule and the balloon collar.
  • Similar to the various procedures described above, at the time the physician desires to deflate the balloon, the patient may be brought into the physician's office in an outpatient setting. In order cause the intragastric balloon 109 to deflate, the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 (FIG. 9). The physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal to the combined microelectronic control and power source 115.
  • Combined microelectronic control and power supply 115 has an antenna (not shown) for receiving the activation signal from remote control 100. Upon receiving the activation signal, combined microelectronic control and power source uses power to begin increasing the temperature of heating element(s) (not shown) that are connected to the torsional spring 113. Similar to the embodiments discussed above that incorporate heating elements, metal film heating elements utilizing materials such as nichrome, stainless steel, copper, gold, or other such materials, can be used for the heating element(s). As the temperature of the heating element(s) begin to increase, the temperature of shape memory torsional spring 113 also begins to increase, thereby causing the spring to deform and reduce in diameter. As the diameter decreases, the seal between valve capsule 111 and balloon collar 114 is broken.
  • Once the seal between the balloon collar 114 and valve capsule 111 is broken and the valve capsule is separated from the shell, fluid contained inside the balloon freely flows through the opening 116 (FIG. 10 b) that is created by the separation of the two portions. Through the normal movements and contraction of the stomach walls, the balloon will drain of the fluid contained inside and shrink down to a size that is passable through the human body. The combined microelectronic control and power supply and heating element(s) are safely contained within the valve capsule such that they do not present any danger to the patient. Because the entire intragastric balloon may now be in two separate pieces—an empty shell and a self-contained valve capsule—the passing of the balloon and valve is facilitated.
  • As with the previous embodiments described, in addition to performing the function of controlling the heating elements, the combined microelectronic control and power supply 115 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • Referring to FIG. 11, another preferred embodiment of an intragastric balloon of the present invention incorporating a remote deflation mechanism is shown. Intragastric balloon 129 is comprised of shell 130 and valve capsule 131. Valve capsule 131 is comprised of valve 132, and combined microelectronic control and power source 135. Shell 130 is comprised of a collar 136, heating element 137, and shape memory cutting element 138. FIG. 11 also shows adjustment tool 141 for adjusting the volume of the intragastric balloon 129.
  • As with several of the other embodiments previously discussed, rather than using a remote deflation mechanism to open the valve of the intragastric balloon, the embodiment of the present invention shown in FIG. 11 utilizes a deflation mechanism for separating the entire valve capsule from the remaining portion of the balloon. When inflated, the valve capsule 131 is held tightly in the balloon collar 114 by pressure exerted by shape memory element 138, creating a seal between the valve capsule and the balloon collar.
  • Similar to the various procedures described above, at the time the physician desires to deflate the balloon, the patient may be brought into the physician's office in an outpatient setting. In order cause the intragastric balloon 129 to deflate, the physician activates the valve opening mechanism remotely and from outside the body, using a remote control 100 (FIG. 9). The physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal to the combined microelectronic control and power source 135.
  • Combined microelectronic control and power supply 135 has an antenna (not shown) for receiving the activation signal from remote control 100. Upon receiving the activation signal, combined microelectronic control and power source uses power to begin increasing the temperature of heating element(s) 137 that are connected to the shape memory cutting element 138. Similar to the embodiments discussed above that incorporate heating elements, metal film heating elements utilizing materials such as nichrome, stainless steel, copper, gold, or other such materials, can be used for the heating element(s). As the temperature of the heating element(s) begin to increase, the temperature of shape memory cutting element 138 also begins to increase, thereby causing the cutting element to cut through the balloon collar 136. With the balloon collar 136 completely cut, the seal between valve capsule 131 and balloon collar 136 is broken.
  • Once the seal between the balloon collar 136 and valve capsule 131 is broken and the valve capsule is separated from the shell, fluid contained inside the balloon freely flows through the opening that is created by the separation of the two portions. Through the normal movements and contraction of the stomach walls, the balloon will drain of the fluid contained inside and shrink down to a size that is passable through the human body. The combined microelectronic control and power supply and heating element(s) are safely contained within the valve capsule such that they do not present any danger to the patient. Because the entire intragastric balloon may now be in two separate pieces—an empty shell and a self-contained valve capsule—the passing of the balloon and valve is facilitated. As an alternative to the cutting mechanism described herein, the remote deflation mechanism may be comprised of a mechanical system (such as a torsional spring) contained within the collar which holds the valve capsule in place until the balloon deflation mechanism is initiated.
  • As with the previous embodiments described, in addition to performing the function of controlling the heating elements, the combined microelectronic control and power supply 135 may communicate with the remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal, the physician and patient may then track the progress of the passing of the device.
  • To ensure the device of the present invention will pass easily, the intragastric balloon of the present invention may be constructed of a very thin, highly acid-resistant shell material. In addition, the intragastric balloon may be shaped to encourage collapse into a bullet shape for smooth passage through the intestines. This shape may be created by pre-formed convolutions in the shell that would expand into a substantially spherical or ellipsoidal shape when inflated, but would retract into its small collapsed shape when the remote deflation mechanism was triggered.
  • The remote control will take the form of a handheld control unit that may feature an LCD display and/or similar type of display and a control panel, such as a keyboard or touchscreen, to operate the device. The remote control may feature a series of menus that allow an operator to program (or read/determine) the microelectronics to contain in memory important information such as the intragastric balloon's size, patient's name, implanting physician, and the date it was implanted. The remote control may communicate with the sensor via telemetry through radiowaves. The FDA and globally recognized communications band (WMTS 402-405 Mhz) may be used in some embodiments, and an authentication process (e.g., digital handshake signal, PIN verification, or other similar verification process) can be used to ensure that the device cannot be accidentally accessed or controlled by another control mechanism other than the remote control. The telemetry control signal can be sent from approximately a foot or possibly a greater distance from the patient and will typically not require the patient to disrobe to query the sensor or to change its parameters. The remote control is preferably able to read and write information to the microelectronics contained in the intragastric balloon. The remote control may also be password controlled to prevent unauthorized personnel from querying the device. The display of the remote control, which may include visual and audio outputs, typically will display or output the sensed parameter of the remote deflation valve's condition or physical parameter whether this parameter is “open”, “closed”, or any other physical parameter that the remote control is adjusted to monitor.
  • EXAMPLES
  • The following examples describe various procedures using the method and device of the present invention.
  • Example 1 Remote Deflation of an Intragastric Balloon Containing a Sealing Plug
  • In this example, the patient is an overweight male who has previously had an intragastric balloon inserted into his stomach. The intragastric balloon has been implanted for a full course of treatment for six months, and the surgeon is prepared to remove the balloon.
  • The removal of the balloon is performed in an outpatient setting at the doctor's office. Reference is made to FIGS. 2 a and 2 b for the remote deflation valve utilized in this example.
  • In order to open deflation valve 16, the physician activates the remote deflation mechanism from outside the body using a remote control 100, such as that depicted in FIG. 9. The physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal through the patient's tissue to the microelectronic control 32.
  • Upon receiving the activation signal, microelectronic control 32 uses power from a battery 33 to begin increasing the temperature of heating element(s) 31. As the temperature of heating element(s) 31 begins to increase, the wax plug 30 begins to melt.
  • As the wax begins to melt, it collects on wicking surfaces 34. The collection of the wax on wicking surfaces 34 prevents the wax from clogging capillaries 35 and allows the fluid contained within intragastric balloon 10 to flow out of the balloon. Once the wax is melted and collected on wicking surfaces 34, capillaries 35 allow the free flow of the fluid contained inside the balloon through valve opening 36. In addition, once the wax is melted, the microelectronic control 32 sends a confirmation signal to the remote control 100, informing the doctor and patient that the deflation device has been activated.
  • Through the normal movements and contraction of the stomach walls, the balloon drains of the saline contained inside and shrinks down to a size that is passable through the human body. The microelectronics, heating elements, and battery are safely contained within the valve structure such that they do not present any danger to the patient.
  • Having received the confirmation signal, the patient may now leave the doctor's office and return home. The patient tracks the passage of the intragastric balloon and informs the doctor when it has passed.
  • Example 2 Remote Deflation of an Intragastric Balloon Containing a Separable Valve
  • In this example, the patient is an overweight female who has previously had an intragastric balloon implanted. After implantation the patient has experienced significant undesired side effects resulting from the implantation, including nausea, vomiting, and general abdominal discomfort. Therefore, the patient desires to have the remote deflation mechanism activated, thus allowing the balloon to be passed.
  • As with the first example, the balloon removal is performed in an outpatient setting at the doctor's office. Reference is made to FIGS. 8 a and 8 b for the remote deflation mechanism utilized in this example.
  • In order to cause the intragastric balloon 90 to deflate, the physician activates the remote deflation mechanism using a remote control 100, such as that depicted in FIG. 9. The physician positions remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal through the tissue of the abdominal cavity to the microelectronic control 95.
  • Microelectronic control 95 has an antenna for receiving the activation signal from remote control 100. Upon receiving the activation signal, microelectronic control uses power from battery 96 to begin increasing the temperature of heating element(s) 93. As the temperature of heating element(s) 93 begins to increase, the temperature of cutting wire 94 also begins to increase. The increased temperature of the cutting wire causes the valve/balloon bond 92 to deteriorate, resulting in separation of the valve 91 from shell 97.
  • As the valve/balloon bond 92 breaks and separates from the shell, the normal movements of the stomach cause the fluid contained inside the balloon to freely flow through the opening 98. The normal movements and contraction of the stomach walls cause the intragastric balloon to completely drain of the fluid contained inside and shrink down to a size that is passable through the human body. The microelectronics, heating elements and battery are safely contained within the valve structure such that they do not present any danger to the patient. Because the entire intragastric balloon may now comprise two separate pieces, the passing of the balloon and valve is facilitated.
  • Once the valve/balloon bond has been broken, the microelectronic control 95 sends a confirmation signal to remote control 100 to confirm that the deflation mechanism has been activated. Following receipt of a confirmation signal by the remote control, the procedure is complete and the patient can return home and wait until the shell and valve assembly pass through the system. The patient tracks the passage of the intragastric balloon and informs the doctor when its has passed.
  • Although the invention has been described and illustrated with a certain degree of particularity, it is understood that the present disclosure has been made only by way of example, and that numerous changes in the combination and arrangement of parts can be resorted to by those skilled in the art without departing from the spirit and scope of the invention, as hereinafter claimed.
  • Example 3 Remote Deflation of an Intragastric Balloon Containing a Valve Capsule
  • In this example, the patient is an overweight male who has previously had an intragastric balloon inserted into his stomach. The intragastric balloon has been implanted for a full course of treatment for six months, and the surgeon is prepared to remove the balloon.
  • The removal of the balloon is performed in an outpatient setting at the doctor's office. Reference is made to FIGS. 10 a and 10 b for the remote deflation valve utilized in this example.
  • In order to deflate balloon 109, the physician activates the remote deflation mechanism from outside the body using a remote control 100, such as that depicted in FIG. 9. The physician holds remote control 100 near the stomach of the patient, and upon depression of a button, remote control 100 sends an activation signal through the patient's tissue to the combined microelectronic control and power source 115.
  • Upon receiving the activation signal, the combined microelectronic control and power source 115 uses power to begin increasing the temperature of heating element(s) (not shown) that are connected to the torsional spring 113. As the temperature of the heating element(s) begin to increase, the temperature of shape memory torsional spring 113 also begins to increase, thereby causing the spring to deform and reduce in diameter. As the diameter decreases, the seal between valve capsule 111 and balloon collar 114 is broken. The valve capsule is separated from the shell, and fluid contained inside the balloon freely flows through the opening 116 (FIG. 10 b) that is created by the separation of the two portions.
  • Through the normal movements and contraction of the stomach walls, the balloon drains of the saline contained inside and shrinks down to a size that is passable through the human body. The combined microelectronics control and power supply and heating element(s) are safely contained within the valve capsule such that they do not present any danger to the patient.
  • Having received the confirmation signal, the patient may now leave the doctor's office and return home. The patient tracks the passage of the intragastric balloon and informs the doctor when it has passed.

Claims (17)

1. An inflatable intragastric balloon useful for facilitating weight loss in a patient in need thereof and suitable for remote deflation comprising:
a shell for containing a volume of fluid introduced therein;
a valve for adjusting the volume of fluid in said shell;
a remotely-activated deflation mechanism for emptying the volume of fluid in said shell; and
a remote control for communicating with said remotely-activated deflation mechanism from outside the patient's body.
2. The intragastric balloon of claim 1, wherein said remotely-activated deflation mechanism comprises a meltable sealing plug.
3. The intragastric balloon of claim 1, wherein said remotely-activated deflation mechanism comprises a shape memory element, wherein application of heat to said shape memory element causes said shape memory element to deform.
4. The intragastric balloon of claim 1 further comprising a quick fill valve.
5. The intragastric balloon of claim 1, wherein said shell comprises at least one of the following materials: diphenyl silicone, PTFE, silicone-polyurethane elastomer, HDPE, LDPE, or parylene coating.
6. The intragastric balloon of claim 3, wherein said shape memory element comprises a shape memory alloy.
7. The intragastric balloon of claim 6, wherein said shape memory element comprises NiTiNOL.
8. The intragastric balloon of claim 3, wherein said shape memory element comprises a shape memory polymer.
9. The intragastric balloon of claim 1, wherein said remotely-activated deflation mechanism further comprises a battery for powering said remote deflation mechanism.
10. The intragastric balloon of claim 1, wherein said remotely-activated deflation mechanism further comprises microelectronics for controlling said remote deflation mechanism.
11. The intragastric balloon of claim 1, wherein said remotely-activated deflation mechanism is powered by induction from outside the patient's body.
12. The intragastric balloon of claim 3, wherein said shape memory element comprises a cutting wire, wherein application of heat to said shape memory element causes said cutting wire to deform, thereby forming an opening in said shell.
13. The intragastric balloon of claim 10, wherein said shape memory element further comprises a plug proximate said cutting wire, wherein upon application of heat, said cutting wire deforms to open said plug.
14. The intragastric balloon of claim 3, wherein said shape memory element comprises a spring and a plug detachably mounted thereto, wherein upon application of heat said spring deforms to open said plug.
15. The intragastric balloon of claim 3, wherein said shape memory element comprises an actuator, and said remotely-activated deflation mechanism comprises a spring collar and an obstruction for holding said spring collar in a first position, and a slit valve, wherein upon application of heat said actuator deforms to eject said obstruction, thereby causing said spring collar to move to a second position in which said slit valve opens.
16. The intragastric balloon of claim 1, wherein the valve is in a self-contained capsule that may be ejected by a remotely-activated deflation mechanism.
17. A method for the in vivo remote deflation and removal from a mammalian body of an intragastric balloon containing a volume of fluid therein comprising the steps of:
remotely activating a deflation mechanism to create an opening in the shell;
allowing normal intragastric movements to drain fluid from the balloon; and
allowing the deflated balloon to pass through the body.
US11/735,194 2007-04-13 2007-04-13 Apparatus and method for remote deflation of intragastric balloon Abandoned US20080255601A1 (en)

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US11/735,194 US20080255601A1 (en) 2007-04-13 2007-04-13 Apparatus and method for remote deflation of intragastric balloon
PCT/US2008/059766 WO2008127941A2 (en) 2007-04-13 2008-04-09 Remote deflation of intragastric balloon
CA2683715A CA2683715C (en) 2007-04-13 2008-04-09 Apparatus and method for remote deflation of intragastric balloon
AU2008239896A AU2008239896A1 (en) 2007-04-13 2008-04-09 Remote deflation of intragastric balloon
CN200880019831A CN101677868A (en) 2007-04-13 2008-04-09 Remote deflation of intragastric balloon
MX2009011021A MX2009011021A (en) 2007-04-13 2008-04-09 Remote deflation of intragastric balloon.
ES08745382T ES2370929T3 (en) 2007-04-13 2008-04-09 REMOVED INTRAGASTRIC BALL REMOVAL.
EP08745382A EP2139439B1 (en) 2007-04-13 2008-04-09 Remote deflation of intragastric balloon
KR1020097023350A KR20100016353A (en) 2007-04-13 2008-04-09 Remote deflation of intragastric balloon
BRPI0810639A BRPI0810639A2 (en) 2007-04-13 2008-04-09 "apparatus and method for remote emptying of intragastric balloon".
JP2010503182A JP2010523280A (en) 2007-04-13 2008-04-09 Remote contraction of intragastric balloon
AT08745382T ATE522191T1 (en) 2007-04-13 2008-04-09 REMOTE-CONTROLLED DEFLATION OF A STOMACH BALLOON
US12/698,906 US9173757B2 (en) 2007-04-13 2010-02-02 Apparatus and method for remote deflation of intragastric balloon
HK10104435.3A HK1136482A1 (en) 2007-04-13 2010-05-06 Remote deflation of intragastric balloon

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US12/698,906 Active 2028-04-06 US9173757B2 (en) 2007-04-13 2010-02-02 Apparatus and method for remote deflation of intragastric balloon

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AT (1) ATE522191T1 (en)
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Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070100368A1 (en) * 2005-10-31 2007-05-03 Quijano Rodolfo C Intragastric space filler
US20070288033A1 (en) * 2006-06-09 2007-12-13 Allergan, Inc. Intragastric balloon retrieval mechanisms
US20080172079A1 (en) * 2006-09-29 2008-07-17 Allergan, Inc. Apparatus and method for intragastric balloon with in situ adjustment means
US20080243071A1 (en) * 2007-03-30 2008-10-02 Quijano Rodolfo C Intragastric balloon system and therapeutic processes and products
US20100130998A1 (en) * 2002-05-09 2010-05-27 Alverdy John C Balloon System and Methods for Treating Obesity
WO2011038270A3 (en) * 2009-09-24 2011-10-06 Reshape Medical, Inc. Normalization and stabilization of balloon surfaces for deflation
WO2012158972A2 (en) * 2011-05-17 2012-11-22 Endobese, Inc. Method and apparatus for buoyant gastric implant
US20130289604A1 (en) * 2011-01-21 2013-10-31 Obalon Therapeutics, Inc Intragastric device
US8683881B2 (en) 2009-04-03 2014-04-01 Reshape Medical, Inc. Intragastric space fillers and methods of manufacturing including in vitro testing
US8864840B2 (en) 2010-10-19 2014-10-21 Apollo Endosurgery, Inc. Intragastric implants with collapsible frames
US8870966B2 (en) 2010-10-18 2014-10-28 Apollo Endosurgery, Inc. Intragastric balloon for treating obesity
US8888732B2 (en) 2011-03-11 2014-11-18 Apollo Endosurgery, Inc. Intraluminal sleeve with active agents
US8920447B2 (en) 2010-10-19 2014-12-30 Apollo Endosurgery, Inc. Articulated gastric implant clip
US8956380B2 (en) 2010-10-18 2015-02-17 Apollo Endosurgery, Inc. Reactive intragastric implant devices
US9050174B2 (en) 2009-07-23 2015-06-09 Reshape Medical, Inc. Deflation and removal of implantable medical devices
US9149611B2 (en) 2010-02-08 2015-10-06 Reshape Medical, Inc. Materials and methods for improved intragastric balloon devices
US9174031B2 (en) 2009-03-13 2015-11-03 Reshape Medical, Inc. Device and method for deflation and removal of implantable and inflatable devices
US9173757B2 (en) 2007-04-13 2015-11-03 Apollo Endosurgery, Inc. Apparatus and method for remote deflation of intragastric balloon
US9192501B2 (en) 2010-04-30 2015-11-24 Apollo Endosurgery, Inc. Remotely powered remotely adjustable gastric band system
US9198790B2 (en) 2010-10-19 2015-12-01 Apollo Endosurgery, Inc. Upper stomach gastric implants
US9283102B2 (en) 2007-06-25 2016-03-15 Reshape Medical, Inc. Gastric space filler device, delivery system, and related methods
US9358143B2 (en) 2009-07-22 2016-06-07 Reshape Medical, Inc. Retrieval mechanisms for implantable medical devices
US9398969B2 (en) 2010-10-19 2016-07-26 Apollo Endosurgery, Inc. Upper stomach gastric implants
US9463107B2 (en) 2010-10-18 2016-10-11 Apollo Endosurgery, Inc. Variable size intragastric implant devices
US9498365B2 (en) 2010-10-19 2016-11-22 Apollo Endosurgery, Inc. Intragastric implants with multiple fluid chambers
US9604038B2 (en) 2009-07-23 2017-03-28 Reshape Medical, Inc. Inflation and deflation mechanisms for inflatable medical devices
US9622896B2 (en) 2010-02-08 2017-04-18 Reshape Medical, Inc. Enhanced aspiration processes and mechanisms for instragastric devices
US9629740B2 (en) 2010-04-06 2017-04-25 Reshape Medical, Inc. Inflation devices for intragastric devices with improved attachment and detachment and associated systems and methods
US9668901B2 (en) 2010-10-18 2017-06-06 Apollo Endosurgery Us, Inc. Intragastric implants with duodenal anchors
US9681973B2 (en) 2010-02-25 2017-06-20 Reshape Medical, Inc. Enhanced explant processes and mechanisms for intragastric devices
US9895248B2 (en) 2014-10-09 2018-02-20 Obalon Therapeutics, Inc. Ultrasonic systems and methods for locating and/or characterizing intragastric devices
US10070980B2 (en) 2010-10-19 2018-09-11 Apollo Endosurgery Us, Inc. Anchored non-piercing duodenal sleeve and delivery systems
US20180346330A1 (en) * 2015-11-24 2018-12-06 Ge Aviation Systems Limited Solid state delivery system
US10264995B2 (en) 2013-12-04 2019-04-23 Obalon Therapeutics, Inc. Systems and methods for locating and/or characterizing intragastric devices
US10335303B2 (en) 2015-12-07 2019-07-02 Obalon Therapeutics, Inc. Intragastric device
US10350100B2 (en) 2016-04-12 2019-07-16 Obalon Therapeutics, Inc. System for detecting an intragastric balloon
US10537453B2 (en) 2015-12-16 2020-01-21 Obalon Therapeutics, Inc. Intragastric device with expandable portions
US10874537B2 (en) 2008-10-16 2020-12-29 Obalon Therapeutics, Inc. Intragastric volume-occupying device and method for fabricating same
US11819433B2 (en) 2016-11-04 2023-11-21 Reshape Lifesciences Inc. Pressure control system for intragastric device

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100114311A1 (en) * 2008-11-05 2010-05-06 Hilton Becker Multi-Lumen Breast Prothesis and Improved Valve Assembly Therefor
KR101877776B1 (en) * 2011-08-09 2018-07-12 엘지디스플레이 주식회사 Driving integrated circuit for backlight driver and liquid crystal display device including the same
US10182932B2 (en) 2012-02-21 2019-01-22 Allurion Technologies, Inc. Methods and devices for deploying and releasing a temporary implant within the body
US8974483B2 (en) 2012-02-21 2015-03-10 Allurion Technologies, Inc. Methods and devices for deploying and releasing a temporary implant within the body
JP6311936B2 (en) 2012-02-21 2018-04-18 アルリオン テクノロジーズ, インク. Method and apparatus for deploying and expelling temporary implants in the body
WO2014074625A1 (en) * 2012-02-21 2014-05-15 Allurion Technologies, Inc. Anatomically adapted ingestible delivery systems and methods
CN110448398B (en) * 2013-11-01 2021-07-06 阿勒里恩科技公司 Method and apparatus for deploying and releasing a temporary implant in the body
JP2018521708A (en) * 2015-06-11 2018-08-09 オバロン・セラピューティクス、インコーポレイテッドObalon Therapeutics, Inc. Intragastric device system
BR112019016422A2 (en) * 2017-02-09 2020-04-07 Spatz FGIA Ltd check valve with gastrointestinal balloon docking station
WO2019165449A1 (en) 2018-02-26 2019-08-29 Allurion Technologies, Inc. Automatic-sealing balloon-filling catheter system
CN114376777B (en) 2018-07-06 2024-02-02 安瑞仁科技公司 Binary fluid control valve system
BR112021011198A2 (en) 2018-12-13 2021-08-31 Allurion Technologies, Inc. MEDICAL DEVICE FOR POSITIONING IN A PATIENT, FLUID DISTRIBUTION SYSTEM FOR POSITIONING A MEDICAL DEVICE IN A PATIENT AND DELIVERY A FLUID TO A CLOSED RESERVOIR IN THE DEVICE AND FLUID DISTRIBUTION SYSTEM TO PLACE A MEDICAL DEVICE IN A PATIENT AND DELIVER A FLUID TO A CLOSED RESERVOIR ON THE DEVICE
CN111345927A (en) * 2018-12-20 2020-06-30 上海微创医疗器械(集团)有限公司 Sacculus, sacculus connection structure and sacculus device
JP7266505B2 (en) 2019-10-15 2023-04-28 英敏 太田 Gastric space filling device and method of operation thereof

Citations (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1702974A (en) * 1928-05-12 1929-02-19 Spalding & Bros Ag Collapsible valve and method of making same
US3919724A (en) * 1974-06-07 1975-11-18 Medical Eng Corp Implantable prosthesis having a self-sealing valve
US4430392A (en) * 1983-02-11 1984-02-07 Honeywell Inc. Heat activated vent
US4485805A (en) * 1982-08-24 1984-12-04 Gunther Pacific Limited Of Hong Kong Weight loss device and method
US4607618A (en) * 1983-02-23 1986-08-26 Angelchik Jean P Method for treatment of morbid obesity
US4636213A (en) * 1985-01-24 1987-01-13 Pakiam Anthony I Implantable prosthesis
US4694827A (en) * 1986-01-14 1987-09-22 Weiner Brian C Inflatable gastric device for treating obesity and method of using the same
US4930535A (en) * 1987-05-14 1990-06-05 Mcghan Medical Corporation Folding leaf valve and method of making
US4969899A (en) * 1989-03-08 1990-11-13 Cox-Uphoff International Inflatable implant
US5084061A (en) * 1987-09-25 1992-01-28 Gau Fred C Intragastric balloon with improved valve locating means
US5211371A (en) * 1991-07-22 1993-05-18 Advanced Control Technologies, Inc. Linearly actuated valve
US5725507A (en) * 1994-03-04 1998-03-10 Mentor Corporation Self-sealing injection sites and plugs
US5819749A (en) * 1995-09-25 1998-10-13 Regents Of The University Of California Microvalve
US6102897A (en) * 1996-11-19 2000-08-15 Lang; Volker Microvalve
US6454785B2 (en) * 2000-02-24 2002-09-24 DE HOYOS GARZA ANDRéS Percutaneous intragastric balloon catheter for the treatment of obesity
US20030106761A1 (en) * 2001-12-07 2003-06-12 Taylor William Morris Shape memory alloy wrap spring clutch
US6579301B1 (en) * 2000-11-17 2003-06-17 Syntheon, Llc Intragastric balloon device adapted to be repeatedly varied in volume without external assistance
US6629776B2 (en) * 2000-12-12 2003-10-07 Mini-Mitter Company, Inc. Digital sensor for miniature medical thermometer, and body temperature monitor
US6733513B2 (en) * 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US6733512B2 (en) * 2002-03-07 2004-05-11 Mcghan Jim J. Self-deflating intragastric balloon
US6746460B2 (en) * 2002-08-07 2004-06-08 Satiety, Inc. Intra-gastric fastening devices
US20050055039A1 (en) * 2003-07-28 2005-03-10 Polymorfix, Inc. Devices and methods for pyloric anchoring
US20050190070A1 (en) * 2001-03-07 2005-09-01 Telezygology Inc. Closure with concertina element and processing means
US20050192615A1 (en) * 2000-11-03 2005-09-01 Torre Roger D.L. Method and device for use in minimally invasive placement of intragastric devices
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050250979A1 (en) * 2002-08-13 2005-11-10 Coe Frederick L Remotely adjustable gastric banding device and method
US20050267596A1 (en) * 2004-05-03 2005-12-01 Fulfillium, Inc. A Delaware Corporation Devices and systems for gastric volume control
US7020531B1 (en) * 2001-05-01 2006-03-28 Intrapace, Inc. Gastric device and suction assisted method for implanting a device on a stomach wall
US20060069403A1 (en) * 2004-09-21 2006-03-30 Shalon Ventures, Inc. Tissue expansion devices
US7056305B2 (en) * 2001-03-09 2006-06-06 Garza Alvarez Jose Rafael Intragastric balloon assembly
US20060142700A1 (en) * 2003-06-20 2006-06-29 Sobelman Owen S Two-way slit valve
US20070016262A1 (en) * 2005-07-13 2007-01-18 Betastim, Ltd. Gi and pancreatic device for treating obesity and diabetes
US20070083224A1 (en) * 2005-06-16 2007-04-12 Hively Robert L Gastric bariatric apparatus with selective inflation and safety features
US7214233B2 (en) * 2002-08-30 2007-05-08 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US20070156248A1 (en) * 2005-03-01 2007-07-05 Doron Marco Bioerodible self-deployable intragastric implants

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2163048A (en) 1937-02-13 1939-06-20 Mckee Brothers Corp Band clamp
BE758322A (en) 1969-11-03 1971-04-01 Bosch Gmbh Robert DEVICE FOR WIPING GLASSES SUCH AS HEADLIGHT GLASS AND REAR LAMP OF MOTOR VEHICLES
US3719973A (en) 1972-03-03 1973-03-13 Might Mac Inc T-bar zipper tab handle
US3840018A (en) 1973-01-31 1974-10-08 M Heifetz Clamp for occluding tubular conduits in the human body
US4118805A (en) 1977-02-28 1978-10-10 Codman & Shurtleff, Inc. Artificial sphincter
GB2086792B (en) 1980-11-07 1984-12-12 Microsurgical Administrative S Gripping devices
US4545367A (en) 1982-07-16 1985-10-08 Cordis Corporation Detachable balloon catheter and method of use
IL67773A (en) 1983-01-28 1985-02-28 Antebi E Tie for tying live tissue and an instrument for performing said tying operation
US4881939A (en) 1985-02-19 1989-11-21 The Johns Hopkins University Implantable helical cuff
US4723547A (en) 1985-05-07 1988-02-09 C. R. Bard, Inc. Anti-obesity balloon placement system
US4598699A (en) 1985-06-10 1986-07-08 Garren Lloyd R Endoscopic instrument for removing stomach insert
JPS63264078A (en) 1987-04-22 1988-10-31 オリンパス光学工業株式会社 Balloon for diet
JPS63279854A (en) 1987-05-12 1988-11-16 Olympus Optical Co Ltd Diet balloon extracting apparatus
DE8804765U1 (en) 1988-04-12 1989-05-11 Witzel, Lothar, Prof. Dr., 1000 Berlin, De
US5527340A (en) 1990-04-20 1996-06-18 S & T Marketing Ag Surgical instrument with gripping portion
US5074868A (en) 1990-08-03 1991-12-24 Inamed Development Company Reversible stoma-adjustable gastric band
US5226429A (en) 1991-06-20 1993-07-13 Inamed Development Co. Laparoscopic gastric band and method
US5289817A (en) 1991-08-20 1994-03-01 Linvatec Corporation Endoscopic surgical retractor
US5972000A (en) 1992-11-13 1999-10-26 Influence Medical Technologies, Ltd. Non-linear anchor inserter device and bone anchors
US5449368A (en) 1993-02-18 1995-09-12 Kuzmak; Lubomyr I. Laparoscopic adjustable gastric banding device and method for implantation and removal thereof
US5601604A (en) 1993-05-27 1997-02-11 Inamed Development Co. Universal gastric band
JP3694524B2 (en) 1993-08-23 2005-09-14 ボストン サイエンティフィック コーポレイション Improved balloon catheter
US5658298A (en) 1993-11-09 1997-08-19 Inamed Development Company Laparoscopic tool
JP3707822B2 (en) 1995-03-23 2005-10-19 富士写真フイルム株式会社 Image display device
US6102922A (en) 1995-09-22 2000-08-15 Kirk Promotions Limited Surgical method and device for reducing the food intake of patient
US5997517A (en) 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
DE69723955D1 (en) 1997-04-04 2003-09-11 Christian Peclat Peristaltic pump
US5938669A (en) 1997-05-07 1999-08-17 Klasamed S.A. Adjustable gastric banding device for contracting a patient's stomach
US6074341A (en) 1998-06-09 2000-06-13 Timm Medical Technologies, Inc. Vessel occlusive apparatus and method
JP3426510B2 (en) 1998-07-27 2003-07-14 ペンタックス株式会社 High frequency snare for endoscope
FR2783153B1 (en) 1998-09-14 2000-12-01 Jerome Dargent GASTRIC CONSTRICTION DEVICE
US6290575B1 (en) 1999-03-01 2001-09-18 John I. Shipp Surgical ligation clip with increased ligating force
FR2797181B1 (en) 1999-08-05 2002-05-03 Richard Cancel REMOTE GASTRIC BAND DEVICE FOR FORMING A RESTRICTED STOMA OPENING IN THE ESTOMAC
US6464628B1 (en) 1999-08-12 2002-10-15 Obtech Medical Ag Mechanical anal incontinence
US6454699B1 (en) 2000-02-11 2002-09-24 Obtech Medical Ag Food intake restriction with controlled wireless energy supply
US6371971B1 (en) 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
US6470892B1 (en) 2000-02-10 2002-10-29 Obtech Medical Ag Mechanical heartburn and reflux treatment
US6503264B1 (en) 2000-03-03 2003-01-07 Bioenterics Corporation Endoscopic device for removing an intragastric balloon
US6513403B2 (en) 2001-04-03 2003-02-04 Cray Inc. Flexible drive rod for access to enclosed locations
FR2823663B1 (en) 2001-04-18 2004-01-02 Cousin Biotech DEVICE FOR TREATING MORBID OBESITY
DE60112477T2 (en) 2001-05-08 2006-06-08 Arena, Alberto, Cascina PROPORTIONAL VALVE WITH A FORM MEMORY ALLOY DRIVE
US6511490B2 (en) 2001-06-22 2003-01-28 Antoine Jean Henri Robert Gastric banding device and method
US6659937B2 (en) 2001-10-11 2003-12-09 M. Sheldon Polsky Continent bladder access device
FR2834198B1 (en) 2001-12-28 2004-10-15 Cie Euro Etude Rech Paroscopie MEDICAL EXPLANTATION DEVICE
FR2840804B1 (en) 2002-06-13 2004-09-17 Richard Cancel SYSTEM FOR THE TREATMENT OF OBESITY AND IMPLANT FOR SUCH A SYSTEM
DE60331457D1 (en) 2002-08-28 2010-04-08 Allergan Inc TEMPTING MAGNETIC BANDING DEVICE
ATE378029T1 (en) 2002-09-04 2007-11-15 Endoart Sa DEVICE FOR CLOSING SURGICAL RINGS
ES2291405T3 (en) 2002-09-04 2008-03-01 Endoart S.A. SURGICAL RING PROVIDED WITH A REMOTE CONTROL SYSTEM AND REVERSIBLE IN THE VARIATION OF YOUR DIAMETER.
US7613515B2 (en) 2003-02-03 2009-11-03 Enteromedics Inc. High frequency vagal blockage therapy
FR2852821B1 (en) 2003-03-31 2007-06-01 Cie Euro Etude Rech Paroscopie PARYLENE-COATED INTRA-GASTRIC BALLOON, PROCESS FOR PRODUCING SUCH BALLOON AND USE OF PARYLENE FOR COATING INTRA-GASTRIC BALLOON
FR2855744B1 (en) 2003-06-04 2006-04-14 Cie Euro Etude Rech Paroscopie SURGICAL RING WITH IMPROVED CLOSURE SYSTEM
US6994095B2 (en) 2003-07-28 2006-02-07 Medventure Associates Iv Pyloric valve corking device and method
US20090259236A2 (en) 2003-07-28 2009-10-15 Baronova, Inc. Gastric retaining devices and methods
ES2368149T3 (en) 2004-03-18 2011-11-14 Allergan, Inc. APPARATUS FOR ADJUSTMENT OF THE VOLUME OF INTRAGASTRIC BALLOONS.
US20050261711A1 (en) 2004-05-24 2005-11-24 Olympus Corporation Treatment method and endoscope apparatus
US20060025799A1 (en) 2004-07-27 2006-02-02 Patrick Basu Endoscopically placed gastric balloon (EPGB) device and method for treating obesity involving the same
US20070078476A1 (en) 2004-10-12 2007-04-05 Hull Wendell C Sr Overweight control apparatuses for insertion into the stomach
WO2006063593A2 (en) 2004-12-14 2006-06-22 Rune Wessel Weltlesen A system and a method for treating of obesity by use of an intragastric balloon
EP1853205A1 (en) 2005-02-24 2007-11-14 Compagnie Europeenne d' etude et de recherche de di spositfs pour l'implantation par la paroscopie Intragastric balloon with extraction reinforcement
US7736385B2 (en) 2005-03-24 2010-06-15 Cook Incorporated Exchangeable delivery system with distal protection
US9345604B2 (en) 2005-05-02 2016-05-24 Almuhannad Alfrhan Percutaneous intragastric balloon device and method
WO2007011086A1 (en) 2005-07-19 2007-01-25 Hyvix Co., Ltd. Method and apparatus for converting gradation data in lcd
EP1922026A4 (en) 2005-08-11 2010-04-14 Stimplant Ltd Implantable device for obesity prevention
US8936590B2 (en) * 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US20070288033A1 (en) 2006-06-09 2007-12-13 Allergan, Inc. Intragastric balloon retrieval mechanisms
US9326877B2 (en) 2006-09-29 2016-05-03 Apollo Endosurgery, Inc. Apparatus and method for intragastric balloon with in situ adjustment means
US8226602B2 (en) 2007-03-30 2012-07-24 Reshape Medical, Inc. Intragastric balloon system and therapeutic processes and products
US20080255601A1 (en) 2007-04-13 2008-10-16 Allergan, Inc. Apparatus and method for remote deflation of intragastric balloon
DE102007025312A1 (en) 2007-05-25 2008-11-27 Q Medical International Ag Intragastric stomach use for the treatment of obesity
EP2224887A2 (en) 2007-10-23 2010-09-08 Allergan, Inc. Pressure sensing intragastric balloon
EP2240140B8 (en) 2008-01-29 2022-05-18 Implantica Patent Ltd. An apparatus for treating gerd
US20090259246A1 (en) 2008-04-14 2009-10-15 Sherif Eskaros Intragastric Volume-Occupying Device
EP2362762A1 (en) 2008-10-06 2011-09-07 Allergan Medical Sàrl Mechanical gastric band with cushions
US9364362B2 (en) 2008-10-21 2016-06-14 General Electric Company Implantable device system
FR2941617B1 (en) 2009-02-04 2012-06-29 Endalis INTRA-GASTRIC BALLOON.

Patent Citations (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1702974A (en) * 1928-05-12 1929-02-19 Spalding & Bros Ag Collapsible valve and method of making same
US3919724A (en) * 1974-06-07 1975-11-18 Medical Eng Corp Implantable prosthesis having a self-sealing valve
US4485805A (en) * 1982-08-24 1984-12-04 Gunther Pacific Limited Of Hong Kong Weight loss device and method
US4430392A (en) * 1983-02-11 1984-02-07 Honeywell Inc. Heat activated vent
US4607618A (en) * 1983-02-23 1986-08-26 Angelchik Jean P Method for treatment of morbid obesity
US4636213A (en) * 1985-01-24 1987-01-13 Pakiam Anthony I Implantable prosthesis
US4694827A (en) * 1986-01-14 1987-09-22 Weiner Brian C Inflatable gastric device for treating obesity and method of using the same
US4930535A (en) * 1987-05-14 1990-06-05 Mcghan Medical Corporation Folding leaf valve and method of making
US5084061A (en) * 1987-09-25 1992-01-28 Gau Fred C Intragastric balloon with improved valve locating means
US4969899A (en) * 1989-03-08 1990-11-13 Cox-Uphoff International Inflatable implant
US5211371A (en) * 1991-07-22 1993-05-18 Advanced Control Technologies, Inc. Linearly actuated valve
US5725507A (en) * 1994-03-04 1998-03-10 Mentor Corporation Self-sealing injection sites and plugs
US5819749A (en) * 1995-09-25 1998-10-13 Regents Of The University Of California Microvalve
US6102897A (en) * 1996-11-19 2000-08-15 Lang; Volker Microvalve
US6733513B2 (en) * 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US6454785B2 (en) * 2000-02-24 2002-09-24 DE HOYOS GARZA ANDRéS Percutaneous intragastric balloon catheter for the treatment of obesity
US20050192615A1 (en) * 2000-11-03 2005-09-01 Torre Roger D.L. Method and device for use in minimally invasive placement of intragastric devices
US6579301B1 (en) * 2000-11-17 2003-06-17 Syntheon, Llc Intragastric balloon device adapted to be repeatedly varied in volume without external assistance
US6629776B2 (en) * 2000-12-12 2003-10-07 Mini-Mitter Company, Inc. Digital sensor for miniature medical thermometer, and body temperature monitor
US20050190070A1 (en) * 2001-03-07 2005-09-01 Telezygology Inc. Closure with concertina element and processing means
US7056305B2 (en) * 2001-03-09 2006-06-06 Garza Alvarez Jose Rafael Intragastric balloon assembly
US7020531B1 (en) * 2001-05-01 2006-03-28 Intrapace, Inc. Gastric device and suction assisted method for implanting a device on a stomach wall
US20030106761A1 (en) * 2001-12-07 2003-06-12 Taylor William Morris Shape memory alloy wrap spring clutch
US6733512B2 (en) * 2002-03-07 2004-05-11 Mcghan Jim J. Self-deflating intragastric balloon
US6746460B2 (en) * 2002-08-07 2004-06-08 Satiety, Inc. Intra-gastric fastening devices
US20050250979A1 (en) * 2002-08-13 2005-11-10 Coe Frederick L Remotely adjustable gastric banding device and method
US7214233B2 (en) * 2002-08-30 2007-05-08 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US7037344B2 (en) * 2002-11-01 2006-05-02 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US20060142700A1 (en) * 2003-06-20 2006-06-29 Sobelman Owen S Two-way slit valve
US20050055039A1 (en) * 2003-07-28 2005-03-10 Polymorfix, Inc. Devices and methods for pyloric anchoring
US20050267596A1 (en) * 2004-05-03 2005-12-01 Fulfillium, Inc. A Delaware Corporation Devices and systems for gastric volume control
US20050267595A1 (en) * 2004-05-03 2005-12-01 Fulfillium, Inc., A Delaware Corporation Methods for gastric volume control
US20060069403A1 (en) * 2004-09-21 2006-03-30 Shalon Ventures, Inc. Tissue expansion devices
US20070156248A1 (en) * 2005-03-01 2007-07-05 Doron Marco Bioerodible self-deployable intragastric implants
US20070083224A1 (en) * 2005-06-16 2007-04-12 Hively Robert L Gastric bariatric apparatus with selective inflation and safety features
US20070016262A1 (en) * 2005-07-13 2007-01-18 Betastim, Ltd. Gi and pancreatic device for treating obesity and diabetes

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100130998A1 (en) * 2002-05-09 2010-05-27 Alverdy John C Balloon System and Methods for Treating Obesity
US9668900B2 (en) 2002-05-09 2017-06-06 Reshape Medical, Inc. Balloon system and methods for treating obesity
US8845672B2 (en) 2002-05-09 2014-09-30 Reshape Medical, Inc. Balloon system and methods for treating obesity
US20070100368A1 (en) * 2005-10-31 2007-05-03 Quijano Rodolfo C Intragastric space filler
US8753369B2 (en) 2006-06-09 2014-06-17 Apollo Endosurgery, Inc. Intragastric balloon retrieval mechanisms
US20070288033A1 (en) * 2006-06-09 2007-12-13 Allergan, Inc. Intragastric balloon retrieval mechanisms
US9125726B2 (en) 2006-06-09 2015-09-08 Apollo Endosurgery, Inc. Intragastric balloon retrieval mechanisms
US20100168783A1 (en) * 2006-06-09 2010-07-01 Allergan, Inc. Intragastric balloon retrieval mechanisms
US20080172079A1 (en) * 2006-09-29 2008-07-17 Allergan, Inc. Apparatus and method for intragastric balloon with in situ adjustment means
US9326877B2 (en) 2006-09-29 2016-05-03 Apollo Endosurgery, Inc. Apparatus and method for intragastric balloon with in situ adjustment means
US8226602B2 (en) 2007-03-30 2012-07-24 Reshape Medical, Inc. Intragastric balloon system and therapeutic processes and products
US20080243071A1 (en) * 2007-03-30 2008-10-02 Quijano Rodolfo C Intragastric balloon system and therapeutic processes and products
US9173757B2 (en) 2007-04-13 2015-11-03 Apollo Endosurgery, Inc. Apparatus and method for remote deflation of intragastric balloon
US9283102B2 (en) 2007-06-25 2016-03-15 Reshape Medical, Inc. Gastric space filler device, delivery system, and related methods
US10874537B2 (en) 2008-10-16 2020-12-29 Obalon Therapeutics, Inc. Intragastric volume-occupying device and method for fabricating same
US11219543B2 (en) 2008-10-16 2022-01-11 Reshape Lifesciences Inc. Intragastric device
US9174031B2 (en) 2009-03-13 2015-11-03 Reshape Medical, Inc. Device and method for deflation and removal of implantable and inflatable devices
US8683881B2 (en) 2009-04-03 2014-04-01 Reshape Medical, Inc. Intragastric space fillers and methods of manufacturing including in vitro testing
US8840952B2 (en) 2009-04-03 2014-09-23 Reshape Medical, Inc. Intragastric space fillers and methods of manufacturing including in vitro testing
US9358143B2 (en) 2009-07-22 2016-06-07 Reshape Medical, Inc. Retrieval mechanisms for implantable medical devices
US9987470B2 (en) 2009-07-23 2018-06-05 ReShape Medical, LLC Deflation and removal of implantable medical devices
US9050174B2 (en) 2009-07-23 2015-06-09 Reshape Medical, Inc. Deflation and removal of implantable medical devices
US9604038B2 (en) 2009-07-23 2017-03-28 Reshape Medical, Inc. Inflation and deflation mechanisms for inflatable medical devices
US8894568B2 (en) 2009-09-24 2014-11-25 Reshape Medical, Inc. Normalization and stabilization of balloon surfaces for deflation
WO2011038270A3 (en) * 2009-09-24 2011-10-06 Reshape Medical, Inc. Normalization and stabilization of balloon surfaces for deflation
US9579226B2 (en) 2010-02-08 2017-02-28 Reshape Medical, Inc. Materials and methods for improved intragastric balloon devices
US9149611B2 (en) 2010-02-08 2015-10-06 Reshape Medical, Inc. Materials and methods for improved intragastric balloon devices
US9622896B2 (en) 2010-02-08 2017-04-18 Reshape Medical, Inc. Enhanced aspiration processes and mechanisms for instragastric devices
US9681973B2 (en) 2010-02-25 2017-06-20 Reshape Medical, Inc. Enhanced explant processes and mechanisms for intragastric devices
US9629740B2 (en) 2010-04-06 2017-04-25 Reshape Medical, Inc. Inflation devices for intragastric devices with improved attachment and detachment and associated systems and methods
US10117766B2 (en) 2010-04-06 2018-11-06 Reshape Medical Llc Inflation devices for intragastric devices with improved attachment and detachment and associated systems and methods
US9192501B2 (en) 2010-04-30 2015-11-24 Apollo Endosurgery, Inc. Remotely powered remotely adjustable gastric band system
US8956380B2 (en) 2010-10-18 2015-02-17 Apollo Endosurgery, Inc. Reactive intragastric implant devices
US9668901B2 (en) 2010-10-18 2017-06-06 Apollo Endosurgery Us, Inc. Intragastric implants with duodenal anchors
US9463107B2 (en) 2010-10-18 2016-10-11 Apollo Endosurgery, Inc. Variable size intragastric implant devices
US8870966B2 (en) 2010-10-18 2014-10-28 Apollo Endosurgery, Inc. Intragastric balloon for treating obesity
US9795498B2 (en) 2010-10-18 2017-10-24 Apollo Endosurgery Us, Inc. Intragastric balloon for treating obesity
US9498365B2 (en) 2010-10-19 2016-11-22 Apollo Endosurgery, Inc. Intragastric implants with multiple fluid chambers
US10070980B2 (en) 2010-10-19 2018-09-11 Apollo Endosurgery Us, Inc. Anchored non-piercing duodenal sleeve and delivery systems
US9801747B2 (en) 2010-10-19 2017-10-31 Apollo Endosurgery Us, Inc. Non-inflatable gastric implants and systems
US9539133B2 (en) 2010-10-19 2017-01-10 Apollo Endosurgery, Inc. Stomach-spanning gastric implants
US9398969B2 (en) 2010-10-19 2016-07-26 Apollo Endosurgery, Inc. Upper stomach gastric implants
US8864840B2 (en) 2010-10-19 2014-10-21 Apollo Endosurgery, Inc. Intragastric implants with collapsible frames
US9198790B2 (en) 2010-10-19 2015-12-01 Apollo Endosurgery, Inc. Upper stomach gastric implants
US8920447B2 (en) 2010-10-19 2014-12-30 Apollo Endosurgery, Inc. Articulated gastric implant clip
US9681974B2 (en) 2010-10-19 2017-06-20 Apollo Endosurgery Us, Inc. Intragastric implants with collapsible frames
US11737899B2 (en) 2011-01-21 2023-08-29 Reshape Lifesciences Inc. Intragastric device
US9662239B2 (en) 2011-01-21 2017-05-30 Obalon Therapeutics, Inc. Intragastric device
US10610396B2 (en) 2011-01-21 2020-04-07 Obalon Therapeutics, Inc. Intragastric device
US9827128B2 (en) 2011-01-21 2017-11-28 Obalon Therapeutics, Inc. Intragastric device
US20130289604A1 (en) * 2011-01-21 2013-10-31 Obalon Therapeutics, Inc Intragastric device
US8740927B2 (en) * 2011-01-21 2014-06-03 Obalon Therapeutics Inc. Intragastric device
US11779482B2 (en) 2011-01-21 2023-10-10 Reshape Lifesciences Inc. Intragastric device
EP3117865A1 (en) * 2011-01-21 2017-01-18 Obalon Therapeutics, Inc. Intragastric device
KR101806089B1 (en) 2011-01-21 2017-12-07 오발론 테라퓨틱스 인코퍼레이티드 Intragastric Device
EP3284504A3 (en) * 2011-01-21 2018-06-27 Obalon Therapeutics, Inc. Intragastric device
US10463520B2 (en) 2011-01-21 2019-11-05 Obalon Therapeutics, Inc. Intragastric device
US8888732B2 (en) 2011-03-11 2014-11-18 Apollo Endosurgery, Inc. Intraluminal sleeve with active agents
WO2012158972A2 (en) * 2011-05-17 2012-11-22 Endobese, Inc. Method and apparatus for buoyant gastric implant
WO2012158972A3 (en) * 2011-05-17 2013-01-31 Endobese, Inc. Method and apparatus for buoyant gastric implant
US20170042714A1 (en) * 2011-05-17 2017-02-16 Endobese, Inc. Method and apparatus for buoyant gastric implant
US10264995B2 (en) 2013-12-04 2019-04-23 Obalon Therapeutics, Inc. Systems and methods for locating and/or characterizing intragastric devices
US9895248B2 (en) 2014-10-09 2018-02-20 Obalon Therapeutics, Inc. Ultrasonic systems and methods for locating and/or characterizing intragastric devices
US11040875B2 (en) * 2015-11-24 2021-06-22 Ge Aviation Systems Limited Solid state delivery system
US20210309514A1 (en) * 2015-11-24 2021-10-07 Ge Aviation Systems Limited Solid state delivery system
US20180346330A1 (en) * 2015-11-24 2018-12-06 Ge Aviation Systems Limited Solid state delivery system
US10335303B2 (en) 2015-12-07 2019-07-02 Obalon Therapeutics, Inc. Intragastric device
US10537453B2 (en) 2015-12-16 2020-01-21 Obalon Therapeutics, Inc. Intragastric device with expandable portions
US10350100B2 (en) 2016-04-12 2019-07-16 Obalon Therapeutics, Inc. System for detecting an intragastric balloon
US11819433B2 (en) 2016-11-04 2023-11-21 Reshape Lifesciences Inc. Pressure control system for intragastric device

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