US20090192410A1 - Universal diagnostic system - Google Patents
Universal diagnostic system Download PDFInfo
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- US20090192410A1 US20090192410A1 US12/359,891 US35989109A US2009192410A1 US 20090192410 A1 US20090192410 A1 US 20090192410A1 US 35989109 A US35989109 A US 35989109A US 2009192410 A1 US2009192410 A1 US 2009192410A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
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- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
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- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150221—Valves
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- A61B5/150854—Communication to or from blood sampling device long distance, e.g. between patient's home and doctor's office
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- A61B5/15188—Constructional features of reusable driving devices
- A61B5/1519—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L67/00—Network arrangements or protocols for supporting network services or applications
- H04L67/01—Protocols
- H04L67/02—Protocols based on web technology, e.g. hypertext transfer protocol [HTTP]
- H04L67/025—Protocols based on web technology, e.g. hypertext transfer protocol [HTTP] for remote control or remote monitoring of applications
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- H—ELECTRICITY
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- H04L67/10—Protocols in which an application is distributed across nodes in the network
- H04L67/1097—Protocols in which an application is distributed across nodes in the network for distributed storage of data in networks, e.g. transport arrangements for network file system [NFS], storage area networks [SAN] or network attached storage [NAS]
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- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15121—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising piezos
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- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15123—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising magnets or solenoids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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Definitions
- the present invention relates to portable medical devices. More particularly to a point-of-care (“POC”) medical diagnostic system with communication capabilities.
- POC point-of-care
- POC testing is attractive because it rapidly delivers results to the medical practitioner and enables faster consultation with the patient. Thus, early diagnosis can enable the practitioner to commence treatment sooner, perhaps leading towards improved patient outcomes.
- POC tests include blood chemistry, such as glucose, hematology, immuno-diagnostics, drugs of abuse, serum cholesterol, fecal occult blood test (“FOBT”), pregnancy, and ovulation.
- blood chemistry such as glucose, hematology, immuno-diagnostics, drugs of abuse, serum cholesterol, fecal occult blood test (“FOBT”), pregnancy, and ovulation.
- FOBT fecal occult blood test
- many new types of analytics now being carried out in the DNA arena such as DNA based assays, immuno assays, proteomics and genomics which are likely candidates for POC testing.
- Gene-array chip technology determines a patient's genetic information, which a health-care provider may use to classify the patient in particular genotypes. Medications respond differently depending on the particular patient's genotype. By matching the most effective medication for a particular genotype, the patient may receive superior care by avoiding adverse reactions, while maximizing drug efficacy.
- a portable medical analyzer provides the additional benefit of facilitating the remote patient monitoring of a patient's medical status.
- the effectiveness of monitoring systems depends not only on the range of tests reported and their accuracy, but also on the frequency and rapidity of information gathered regarding the patient's health status.
- a portable medical device can run a range of tests, which cover most of the tests required for diagnosis or therapy monitoring, including blood gases, electrolytes, hematocrit, and various metabolites such as glucose.
- biochemical parameter results from the POC device with physiological parameters (such as ECG, respiration rate, temperature and blood pressure) permits integration of vital signs and blood chemistry on a real time basis, for better disease management. Results can then be tracked over time for trend analysis.
- Portable medical analyzers also have application in the clinical research setting for remote patient evaluation in post surgical recovery, drug therapy and novel pharmaceutical testing using the remote communications ability.
- a method and apparatus for utilizing a portable medical analyzer comprises obtaining a body fluid transmission of the fluid to a cartridge, the cartridge comprising at least one assay sensor module, positioning the cartridge into an analytical detector module, where positioning the cartridge breaks a pressure seal on the cartridge causing the body fluid to flow to an assay sensor on the cartridge, using the analytical detector module to detect the results of the assay sensor, connecting the analytical detector module to a communication module, and transferring the results from the analytical detector module to the communication module.
- FIG. 1 illustrates an embodiment of sampling, assay sensor, analytical detector, and communication modules according to the present invention.
- FIG. 2 illustrates a cut-away view of an embodiment of combined sampling and assay sensor modules with an analytical detector module of a portable medical analyzer.
- FIG. 3 illustrates a cross-sectional view of an embodiment of an assay sensor module layout.
- FIG. 4 illustrates a flow chart of a method of operation for an embodiment of a portable medical analyzer.
- FIG. 5 illustrates a block diagram of an embodiment of a communication module within a network environment.
- FIG. 6 illustrates a flow chart of an embodiment of a method of operation for a portable medical analyzer.
- a portable medical analyzer is described.
- One aspect of the present invention is a portable medical analyzer capable of performing a variety of diagnostic tests.
- Portable may refer to the self-contained nature of the analyzer.
- Portable may further refer to a hand-held format for the analyzer.
- a portable medical analyzer 100 may include a sampling module 110 , an assay sensor module 120 , an analytical detector (AD) module 130 , and a communications module 140 .
- AD analytical detector
- sampling module 110 is a one-step, painless, ergonomic blood sample acquisition module, which provides capillary blood for introduction into an integrated assay sensor module 120 .
- Assay sensor module 120 may be a highly integrated, low-cost, disposable diagnostic cartridge supporting parallel testing of multiple established and emerging diagnostic parameters from body fluids including but not limited to capillary blood, venous blood or blood gases.
- Analytical detector module 130 employs a modularized hardware technology combining appropriate detection and communication technologies. Analytical detector module 130 module may accept a disposable cartridge or series of disposable cartridges for the analysis of body fluids.
- Communication module 140 with bi-directional wireless connectivity to an information infrastructure which can provide a gateway to laboratory and clinical information systems, has an information infrastructure for integrating the use of decentralized diagnostic technologies within general patient care processes.
- Each type of module can be a removable interchangeable component allowing for module packaging and disposability.
- Various combinations of sampling, assay sensor, and analytical detector modules could accommodate a very wide range of diagnostic tests, from blood glucose testing to DNA typing. Any of these combinations would be able to utilize a common communication and information infrastructure adding to the flexible nature of this architecture.
- sampling module 110 can receive fluids using a variety of methods.
- the sampling module can acquire a number of body fluids, including but not limited to blood.
- the fluid can be a liquid and/or a gas.
- the sampling acquisition port of the portable medical analyzer captures body fluid for testing.
- the port can receive fluids from a variety of means of sample acquisition and or transfer, including but not limited to, lancing, injection, pipette, intravenous, and catheter.
- a lancet punctures the skin and a sample collection port, which can be positioned to correspond with the wound created by the lancet, channels the blood to a sample test area or a sample storage chamber.
- Such channeling can be passive (gravity, capillary flow, etc.) or active (aspiration, vacuum, etc.).
- the lancet may be advanced and/or retracted by a variety of mechanical, electrical, electromechanical, piezoelectric, and electromagnetic, or a combination of these types of driving mechanisms.
- Mechanical driving mechanisms can contain a spring, cam or mass actuators to drive the lancet. These include cantilever springs, diaphragms, coil springs, as well as gravity plumbs to actuate the lancet.
- the device is pre-cocked, or the user cocks the device. The device is held against the skin and the user mechanically triggers ballistic launch of the lancet.
- Other types of driving mechanisms may use electrically based driving and triggering methods, electrical, electromechanical, piezoelectric, and electromagnetic, or a combination of these types of driving mechanisms.
- a sampling module 110 and assay sensor module 120 are bundled together in one cartridge. This embodiment is described in further detail with the description of FIG. 2 below.
- the driving mechanism can be combined in the sampling module, assay sensor module, or analytical detector module. It is desired that the lancet in a module be disposed of with the module for biohazard purposes. It is desired that an expensive mechanism, i.e. electronic, be built into the non-disposable portion of the module e.g. communication module or analytical detector module, where as an inexpensive driving mechanism, i.e. cantilever spring may be built into the disposable module. In the embodiment where the sampling and assay sensor module are combined on one cartridge, such an expensive driving mechanism can be contained on analytical detector module 130 , as discussed in FIG. 2 .
- a sampling module 110 may be used to draw blood into a sample acquisition port, which may be separate from the assay sensor.
- a sample acquisition port which may be separate from the assay sensor.
- Such a modular configuration provides flexibility in linking one sampling module 110 with several assay sensors. Blood may thus be allocated to each of the assay sensors thereby, requiring only one lancing event and reducing the donor's discomfort.
- a sampling module 110 can be coupled to an assay sensor module such that the interface is standardized.
- an assay sensor module such that the interface is standardized.
- the Memory Stick Duo® (Sony, Japan) provides a modular solution where the sampling module with a Memory Stick® interface can receive assay sensor modules configured to digital media standards.
- FIG. 2 shows a analytical detector module 130 comprising a slot for cartridge 10 , wherein sampling module 110 and assay sensor module 120 are contained.
- Cartridge 10 is disposable and houses lancet 16 .
- the term “disposable” refers to a fungible feature of the portable medical analyzer, such as a lancet, assay sensor, or cartridge which can be used for one lancing cycle or one analysis and is then discarded.
- Lancet 16 connects to driver 40 that contains the driving mechanism for advancing and retracting the lancet. Lancet 16 is initially retracted and upon retraction embedded within the cartridge 10 .
- embedded refers to the lancet being completely shielded by the cartridge when it is not lancing.
- Driver 40 plugs into cavity 20 of cartridge 10 .
- Driver 40 may be disposable and attached to the cartridge or reusable and attached to the assay sensor.
- Reservoir 22 has a narrow opening sample acquisition port 14 on an ergonomically contoured surface 26 for collecting the blood from a donor, such as from finger 50 lanced by lancet 16 .
- Reservoir 22 may fill passively through gravity, or capillary flow, or actively through aspiration or vacuum collect the blood sample.
- the cartridge 10 can transport the blood sample through small passages (not shown) using active pumping or passive microfluidics, to a specific localized assay sensor 28 for analyzing the blood, which corresponds to a corresponding location on the analytical detector module 130 .
- the analytical detector module 130 can comprise chemical, physical, optical, electrical or other detecting means of evaluating the blood sample by the assay sensor module 120 .
- Cartridge 10 is loaded in a slot 32 within analytical detector module 130 .
- the driver 40 contains the driving mechanism 38 , which is capable of advancing, stopping, and retracting the lancet 16 .
- the slot 32 also contains the detector 48 for evaluating the blood analysis of the assay sensor 28 on the cartridge 10 , which corresponds to the assay sensor 28 on the cartridge 10 which corresponds to detector 48 when the cartridge 10 is loaded into the slot 32 .
- cartridge 10 can be designed with an array of testing locations, which contain a variety of assays sensors and correspond to an array of detectors on the analytical detector module 130 .
- Pins 34 on slot 32 provide electrical contact between the cartridge 10 and the analytical detector module 130 to enable identification of the type of assay sensor, and quality control issues (e.g., expiration date of cartridge).
- cartridge 10 can be in mechanical contact with analytical detector module 120 locking the cartridge 10 in place and puncturing the cartridge 10 to break a vacuum seal and being fluid flow for calibration and create a pressure differential for capillary forces to pull the body fluid sample.
- the cartridge may be developed on a Memory Stick® (Sony Electronics, Japan) digital media standard interface.
- Alternative embodiments contemplate other digital medial standard interfaces including but not limited to Compact Flash®, MulitMedia Card®, Secure Digital®, SmartMedia®, or any other removable portable device.
- the cartridge is of an ultra compact design that has a standard size and connectivity specifications based on the respective standard interface.
- the removable cartridge can be inserted into an assay detector module 130 with a slot and connector corresponding to the standard for PC cards or Memory Stick Duo® detachable cartridge.
- the term “assay sensor” refers to a substrate or location for conducting body fluid analysis, such as but not limited to a biochemical assay.
- the assay sensor module 120 provides an analytical testing platform for the fluid sample.
- the sampling module and assay sensor are bundled together.
- the assay sensor may be a separate component.
- a sample is transported through the assay sensor module to particular assay sensors, through a network of microtubes using active or passive transport.
- FIG. 3 illustrates an embodiment of a configuration of multiple assay sensors and tubes for transport in assay sensor module 120 .
- Assay sensor module 120 comprises a cartridge 300 , which contains multiple assay sensors 400 , each of which correspond to respective detectors (not shown) on analytical detector module 130 .
- Each assay sensor 28 can perform the same analysis, for redundant testing, or a variety of different analysis using reagents stored in reservoirs 380 in the cartridge 300 . These reagents are packaged in the cartridge during manufacture, such that the patient does not have to replenish any reagent to conduct the assay.
- Assay sensors may be chemically or biologically active locations.
- tests can be performed including blood chemistry, hematology, immuno-diagnostics those for drugs of abuse, serum cholesterol, glucose, FOBT, pregnancy, ovulation, along with many new types of analytics now being done in the DNA arena, such as DNA based assays, immuno assays, proteomics and genomics.
- These tests enable analytical detector module 130 to detect characteristics, or information, about the fluid sample.
- the term “information” refers to data determined as a result of analysis from the analytical testing conducted by the portable medical analyzer.
- Blood coming into the cartridge via sample acquisition port 340 is stored in reservoirs 420 so that it can accumulate to volumes appropriate for the relevant assay to be performed. Reagents necessary for the analysis are stored and shielded in reservoirs 380 prior to their use.
- a system of valves (not shown) keeps the reagents and sample fluid confined to appropriate paths in the cartridge 300 .
- the blood and reagents are transported via active or passive transport through micro tubes 320 to assay sensors 420 .
- the micro tubes 320 may be forked to mix the blood and reagents prior to reaching assay sensors 400 . Alternatively, the blood and reagents can mix upon contact with the assay sensor.
- AD Analytical Detector
- the AD module 130 evaluates the assay sensor in the assay sensor module via detectors, which are associated with the assay sensors.
- the AD generates signals corresponding to information or characteristics of the assay sensors.
- the AD module may include signal processing devices and circuitry for the rapid processing of the signals generated by the array of detectors, which correspond to the array of assays.
- detectors including electrical, electrochemical, optical or mechanical can be used to detect results from tests on the assay sensor module.
- the AD module can interface with a standard port on a portable computing device such as a laptop computer, a personal digital assistant (“PDA”), or other portable computing device, including but not limited to a PalmTM Handheld, HandspringTM Visor or Compaq iPAQ®.
- Standard ports include PCMCIA, serial, parallel, USB, IEEE 1394, and other computer connectivity standard ports.
- a non-limiting embodiment of the analytical detection module 130 contemplates a PC card platform, such as a Personal Computer Memory Card International Association (“PCMCIA”) card or HandspringTM SpringboardTM Module.
- PC cards have standard thicknesses, design and pin assignments.
- the PC card physical characteristics include a 68 pin physical interface, length 85.6 mm, width 54.0 mm, and a thickness of either 3.3 mm, 5.0 mm, or 10.5 mm, depending on type.
- PC cards can include a slot for a Memory Stick® or other modular standard for sampling and assay sensor modules, thereby allowing detection and measurement of the assays on the PC card.
- many different assays can be performed in the one detection area.
- the information detected by the analytical detectors contains results from each of these different assays.
- the thin versatile PC card will be able to both accept the cartridge and plug into a standard communication module for performing tests.
- the analytical detector can be adapted for a wide variety of applications.
- the modularity of analytical detector module 130 it can plug into a variety of host communication or computational platforms, ranging from PDAs to bench top systems.
- measurement systems can be configured that range from those suitable for personal use such a glucometer, to instruments for POC hospital application, or even laboratory measurements.
- a communication module 140 can control both local (onboard) and remote (external) communication.
- the receiver can be adapted to receive instructions and/or data from external sources.
- the transmitter can be adapted to transfer the information read from the detector to external databases and systems in remote locations.
- the communication module 140 can also comprise a display adapted to show the information read from the detector locally to a user via an LCD or other visual indicator.
- the remote transmission component can be a wireless component.
- the communication module 140 plays the dual roles of controlling local and remote communication.
- Communication module 140 can be a PDA, such as a PalmTM PDA, a HandspringTM Visor, or a Compaq iPac®.
- Communication module 140 can comprise of a standard PDA hardware and software including a processor, display, RF chip, antenna, and an operating system, which may be expanded by using some type of PC card technology.
- the PDA can be programmed with software to read information from analytical detector module 130 , and transmit the information remotely using an industry standard protocol for communication of medical information.
- Communication module 140 can have a local storage unit in which the information collected can be stored, such as a localized RAM, i.e. DRAM containing a database of information.
- the information can also be sent to and stored on a remote database.
- the remote database can be part of Laboratory Information System, used to manage the information in central and reference laboratories.
- the remote database can display the information to a clinician, who in turn can analyze the information and send back to the user of the device instruction or comments on the results. Any of these functions can also be performed by a local database.
- a communication module in a PDA can transmit and receive information through radio frequency (“RE”), infrared (“IR”), or docking on a cradle as is well known in the art of standard ports for computer peripherals.
- RE radio frequency
- IR infrared
- the communication module can direct information to a screen that displays test results to a user. In another embodiment, the module can direct information through a bi-directional wireless system.
- the communication module 140 can communicate to the user, and communicate with an outside system as well. This connection can be made to a lab, a database, a clinical trial or a Laboratory Information System.
- the Laboratory Information System is an information management system.
- the term “information management system” refers to a system that can be used to manage the data between the portable medical analyzer and a centralized means for collecting and processing information for functions including but not limited to qualified user authentication, quality control, quality assurance, quality reporting, clinical processes, such as low impact on workflow, result review, decision support, and business processes (such as submitting information for billing generation, demonstrating cost-effectiveness, supporting practice guidelines, and direct marketing).
- the information and instructions transmitted to the portable medical analyzer can be directed to the particular user based on personal identification and security information.
- the analyzer has many key features including reliability, security and confidentiality, content distribution, and functionality distribution (such as a application service provider).
- the analyzer can be connected to a central system, or it can stand alone. Once connected to a system, synchronization can take place.
- security and confidentiality are supported by creating authorization and authentication schemes to limit the access to data.
- the functionality distribution includes the creation of multi-tier disruption models, which may include localized computation or centralized server based computation.
- the functionality of the system is adaptive based on the availability of local or remote resources.
- the data collected can be used for blind testing.
- a brokering system can be structured based on the collected personal medical records. The confidentiality of the system allows individuals to sell their medical data anonymously to customers. The customers can then use the data to develop medical technology or evaluate a heath care system.
- a patient management system can be adapted to application distribution and information management.
- the system uses the portable medical analyzer and provides health care organizations with information integration and access to administrative, data management and decision support applications at the point of care.
- the analyzer can be adapted to receive instructions from an administration system to automate processes such as calibration.
- the device can be in constant communication with a central hospital server system. At regular intervals the server can send a communication to the device that calibration is necessary.
- the user can take a calibration cartridge and insert it into the device for calibration. The server can then either confirm that the device is calibrated or tell the user the device must be recalibrated manually.
- the analyzer can be used for viewing of historical data such as previous results and patient trends.
- the analyzer can download past patient results, or store past patient results locally, and after testing show the patient not only the current results but also where they fall within historical trends.
- the analyzer can be a part of the Universal Connectivity Standard for Point-of-Care, for which further information may be forward at www.poccic.org.
- the device may be connected to both other devices and major medical or hospital systems.
- the communication can take place via an IR port, wireless networks or through connected phone lines.
- an analyzer connected to an LIS can compare results from diagnostic tests run in the laboratory of full-size analyzers and develop correlation tables between results from the portable medical analyzer and the laboratory results.
- FIG. 4 illustrates a flow diagram of an embodiment of a method for POC diagnosis using a portable medical analyzer as described in FIG. 1 .
- Sampling module 110 is integrated into assay sensor module 120 in the form of a cartridge with a lancet.
- the user takes the cartridge and presses it against a finger.
- the driving mechanism trigger from the pressure of the trigger or a button on the analyzer.
- the driving mechanism propels the lancet, which lances the skin and draws body fluid (step 410 ).
- Once the cartridge is locked into analytical detector a pressure seal is broken causing calibration fluid, reagents and sampled body fluid to flow through the cartridge (step 420 ).
- the body fluid flows to the location of the assays on the cartridge, allowing for the chemical analysis by sensor and detection by detectors on the analytical detector module (step 430 ).
- the flow calibration fluid is simultaneously with body fluid sample.
- Analytical detector 130 can be connected to communication module 140 through a standardized port. When connected, communication module can provide extra mechanical and electrical power to analytical detector 130 . Once powered, analytical detector 130 can quantify the results of the chemical analysis on the assay sensor module (step 440 ). The results are then transferred from analytical detector module 130 to communication module 140 through the standard pin connections (step 450 ). Communication module 140 can display the results locally for a user and/or transfer the results immediately or at a later time to a central database in a remote location. The entire process, from lancing to results may take as little as a few minutes.
- FIG. 5 illustrates an embodiment of the communication module within a network environment.
- An individual in a home setting 510 with portable medical analyzer 100 can use the analyzer to sample blood. Within the device a series of steps are performed to gather data. Once the data is gathered, it is wirelessly transmitted 520 through a communication network 550 e.g. cellular, microwave, satellite, Internet, etc. to a remote system 570 in the hospital setting 560 .
- the remote system can include computer 540 with a receiver and decoder that places the data into a remote database 530 .
- the computer 540 hosting the remote database can then process and display the information. Either a computer program or an operation at the computer terminal can send information back to the device, such as treatment information.
- the computer 540 can be a network server operating communication network 550 as a Wide Area Network (WAN).
- WAN Wide Area Network
- FIG. 6 is a flow diagram illustrating a method 600 of operation of an embodiment of a communication module within a network environment.
- the analytical detector determines medical results (step 610 )
- one or a combination (or more) of these steps can result.
- the results can be displayed locally (step 620 ), the results can be displayed remotely (step 625 ) or the results can be stored (step 630 ) either locally or remotely or both. If the results are displayed, this can be the end of the process, or then the results can be stored.
- the computer can process the results and create result trends (step 640 ). After the processing of trend results, the trends can be displayed locally, displayed remotely, or not displayed at all.
- Method 600 illustrates the various methods by which the analyzer can communicate and interact with a user and a network.
- Analytical detector modules could be developed to provide other diagnostic measurements such as ECG, or temperature etc. These measurements would then take advantage of the same communication module and communication network to transmit information.
Abstract
A portable medical analyzer comprising a sampling module with a sample port for receiving body fluid, an assay sensor module for analysis of the body fluid, an analytical detector module with detection of information from the assay, and a communications module for transferring the information to a remote location via a wired or wireless network.
Description
- This application is a continuation of U.S. Ser. No. 10/892,874, filed Jul. 16, 2004, which is a continuation of U.S. Ser. No. 09/981,483, filed Oct. 16, 2001, both of which applications are fully incorporated herein by reference.
- 1. Field of the Invention
- The present invention relates to portable medical devices. More particularly to a point-of-care (“POC”) medical diagnostic system with communication capabilities.
- 2. Background of the Invention
- Over the past 30 years, the average life expectancy of North Americans has increased by approximately 13 years, contributing to a rapid increase in the number of people over the age of 65. Thus, there has been a dramatic growth in total health care spending as the population ages. As a result, the use of screening and monitoring diagnostics for early intervention, improved treatment and monitoring has become an important aspect of health care.
- Technological advances have facilitated the development of easy-to-use, rapid diagnostic devices which can be used in a POC setting, closer to the patient, and that have the ability to pick up disease at an earlier stage. POC testing is attractive because it rapidly delivers results to the medical practitioner and enables faster consultation with the patient. Thus, early diagnosis can enable the practitioner to commence treatment sooner, perhaps leading towards improved patient outcomes. Examples of POC tests include blood chemistry, such as glucose, hematology, immuno-diagnostics, drugs of abuse, serum cholesterol, fecal occult blood test (“FOBT”), pregnancy, and ovulation. In addition many new types of analytics now being carried out in the DNA arena (such as DNA based assays, immuno assays, proteomics and genomics) which are likely candidates for POC testing.
- One such example of the potential benefit from a portable medical analyzer in the use of DNA testing is to help doctors prescribe medicine tailored to the particular patient's genotype. Gene-array chip technology determines a patient's genetic information, which a health-care provider may use to classify the patient in particular genotypes. Medications respond differently depending on the particular patient's genotype. By matching the most effective medication for a particular genotype, the patient may receive superior care by avoiding adverse reactions, while maximizing drug efficacy.
- A portable medical analyzer provides the additional benefit of facilitating the remote patient monitoring of a patient's medical status. The effectiveness of monitoring systems depends not only on the range of tests reported and their accuracy, but also on the frequency and rapidity of information gathered regarding the patient's health status. A portable medical device can run a range of tests, which cover most of the tests required for diagnosis or therapy monitoring, including blood gases, electrolytes, hematocrit, and various metabolites such as glucose.
- Combining biochemical parameter results from the POC device with physiological parameters (such as ECG, respiration rate, temperature and blood pressure) permits integration of vital signs and blood chemistry on a real time basis, for better disease management. Results can then be tracked over time for trend analysis. Portable medical analyzers also have application in the clinical research setting for remote patient evaluation in post surgical recovery, drug therapy and novel pharmaceutical testing using the remote communications ability.
- Current POC devices do not provide an integrated solution for patient self-testing to sample acquisition, testing, analysis and connectivity to remote centralized healthcare. Accordingly it is the object of this invention to provide a portable, highly integrated, multi-parameter measurement instrument with IT solutions for data collection, transmission, analysis and on-line decision support. This is achieved by an integrated approach to sample acquisition, a miniaturized multi-parameter low cost test strip or “cartridge,” a companion portable instrument and an information solution for connectivity via a wired or wireless network.
- In accordance with the invention, a method and apparatus for utilizing a portable medical analyzer is provided. The method comprises obtaining a body fluid transmission of the fluid to a cartridge, the cartridge comprising at least one assay sensor module, positioning the cartridge into an analytical detector module, where positioning the cartridge breaks a pressure seal on the cartridge causing the body fluid to flow to an assay sensor on the cartridge, using the analytical detector module to detect the results of the assay sensor, connecting the analytical detector module to a communication module, and transferring the results from the analytical detector module to the communication module.
- It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.
- The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate several embodiments of the invention and together with the description, serve to explain the principles of the invention.
-
FIG. 1 illustrates an embodiment of sampling, assay sensor, analytical detector, and communication modules according to the present invention. -
FIG. 2 illustrates a cut-away view of an embodiment of combined sampling and assay sensor modules with an analytical detector module of a portable medical analyzer. -
FIG. 3 illustrates a cross-sectional view of an embodiment of an assay sensor module layout. -
FIG. 4 illustrates a flow chart of a method of operation for an embodiment of a portable medical analyzer. -
FIG. 5 illustrates a block diagram of an embodiment of a communication module within a network environment. -
FIG. 6 illustrates a flow chart of an embodiment of a method of operation for a portable medical analyzer. - Reference will now be made in detail to the exemplary embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts.
- In accordance with the present invention, a portable medical analyzer is described. One aspect of the present invention is a portable medical analyzer capable of performing a variety of diagnostic tests. Portable may refer to the self-contained nature of the analyzer. Portable may further refer to a hand-held format for the analyzer. As illustrated in
FIG. 1 , a portablemedical analyzer 100 may include asampling module 110, anassay sensor module 120, an analytical detector (AD)module 130, and acommunications module 140. - In one aspect consistent with the present invention,
sampling module 110 is a one-step, painless, ergonomic blood sample acquisition module, which provides capillary blood for introduction into an integratedassay sensor module 120.Assay sensor module 120 may be a highly integrated, low-cost, disposable diagnostic cartridge supporting parallel testing of multiple established and emerging diagnostic parameters from body fluids including but not limited to capillary blood, venous blood or blood gases.Analytical detector module 130 employs a modularized hardware technology combining appropriate detection and communication technologies.Analytical detector module 130 module may accept a disposable cartridge or series of disposable cartridges for the analysis of body fluids.Communication module 140, with bi-directional wireless connectivity to an information infrastructure which can provide a gateway to laboratory and clinical information systems, has an information infrastructure for integrating the use of decentralized diagnostic technologies within general patient care processes. - Each type of module can be a removable interchangeable component allowing for module packaging and disposability. Various combinations of sampling, assay sensor, and analytical detector modules could accommodate a very wide range of diagnostic tests, from blood glucose testing to DNA typing. Any of these combinations would be able to utilize a common communication and information infrastructure adding to the flexible nature of this architecture.
- In a portable medical analyzer,
sampling module 110 can receive fluids using a variety of methods. The sampling module can acquire a number of body fluids, including but not limited to blood. The fluid can be a liquid and/or a gas. The sampling acquisition port of the portable medical analyzer captures body fluid for testing. The port can receive fluids from a variety of means of sample acquisition and or transfer, including but not limited to, lancing, injection, pipette, intravenous, and catheter. In a non-limiting embodiment, a lancet punctures the skin and a sample collection port, which can be positioned to correspond with the wound created by the lancet, channels the blood to a sample test area or a sample storage chamber. Such channeling can be passive (gravity, capillary flow, etc.) or active (aspiration, vacuum, etc.). - The lancet may be advanced and/or retracted by a variety of mechanical, electrical, electromechanical, piezoelectric, and electromagnetic, or a combination of these types of driving mechanisms. Mechanical driving mechanisms can contain a spring, cam or mass actuators to drive the lancet. These include cantilever springs, diaphragms, coil springs, as well as gravity plumbs to actuate the lancet. Typically, the device is pre-cocked, or the user cocks the device. The device is held against the skin and the user mechanically triggers ballistic launch of the lancet. Other types of driving mechanisms may use electrically based driving and triggering methods, electrical, electromechanical, piezoelectric, and electromagnetic, or a combination of these types of driving mechanisms.
- In one embodiment of the invention, a
sampling module 110 andassay sensor module 120 are bundled together in one cartridge. This embodiment is described in further detail with the description ofFIG. 2 below. - The driving mechanism can be combined in the sampling module, assay sensor module, or analytical detector module. It is desired that the lancet in a module be disposed of with the module for biohazard purposes. It is desired that an expensive mechanism, i.e. electronic, be built into the non-disposable portion of the module e.g. communication module or analytical detector module, where as an inexpensive driving mechanism, i.e. cantilever spring may be built into the disposable module. In the embodiment where the sampling and assay sensor module are combined on one cartridge, such an expensive driving mechanism can be contained on
analytical detector module 130, as discussed inFIG. 2 . - Alternatively, a
sampling module 110 may be used to draw blood into a sample acquisition port, which may be separate from the assay sensor. Such a modular configuration provides flexibility in linking onesampling module 110 with several assay sensors. Blood may thus be allocated to each of the assay sensors thereby, requiring only one lancing event and reducing the donor's discomfort. - Alternately, a
sampling module 110 can be coupled to an assay sensor module such that the interface is standardized. For example the Memory Stick Duo® (Sony, Japan) provides a modular solution where the sampling module with a Memory Stick® interface can receive assay sensor modules configured to digital media standards. -
FIG. 2 shows aanalytical detector module 130 comprising a slot forcartridge 10, whereinsampling module 110 andassay sensor module 120 are contained.Cartridge 10 is disposable and houseslancet 16. The term “disposable” refers to a fungible feature of the portable medical analyzer, such as a lancet, assay sensor, or cartridge which can be used for one lancing cycle or one analysis and is then discarded.Lancet 16 connects todriver 40 that contains the driving mechanism for advancing and retracting the lancet.Lancet 16 is initially retracted and upon retraction embedded within thecartridge 10. The term “embedded” refers to the lancet being completely shielded by the cartridge when it is not lancing. -
Driver 40 plugs intocavity 20 ofcartridge 10.Driver 40 may be disposable and attached to the cartridge or reusable and attached to the assay sensor.Reservoir 22 has a narrow openingsample acquisition port 14 on an ergonomically contouredsurface 26 for collecting the blood from a donor, such as fromfinger 50 lanced bylancet 16.Reservoir 22 may fill passively through gravity, or capillary flow, or actively through aspiration or vacuum collect the blood sample. - The
cartridge 10 can transport the blood sample through small passages (not shown) using active pumping or passive microfluidics, to a specificlocalized assay sensor 28 for analyzing the blood, which corresponds to a corresponding location on theanalytical detector module 130. Theanalytical detector module 130 can comprise chemical, physical, optical, electrical or other detecting means of evaluating the blood sample by theassay sensor module 120. -
Cartridge 10 is loaded in aslot 32 withinanalytical detector module 130. Thedriver 40 contains thedriving mechanism 38, which is capable of advancing, stopping, and retracting thelancet 16. Theslot 32 also contains thedetector 48 for evaluating the blood analysis of theassay sensor 28 on thecartridge 10, which corresponds to theassay sensor 28 on thecartridge 10 which corresponds todetector 48 when thecartridge 10 is loaded into theslot 32. Alternately,cartridge 10 can be designed with an array of testing locations, which contain a variety of assays sensors and correspond to an array of detectors on theanalytical detector module 130.Pins 34 onslot 32 provide electrical contact between thecartridge 10 and theanalytical detector module 130 to enable identification of the type of assay sensor, and quality control issues (e.g., expiration date of cartridge). Alternatively,cartridge 10 can be in mechanical contact withanalytical detector module 120 locking thecartridge 10 in place and puncturing thecartridge 10 to break a vacuum seal and being fluid flow for calibration and create a pressure differential for capillary forces to pull the body fluid sample. - In one embodiment of the invention, the cartridge may be developed on a Memory Stick® (Sony Electronics, Japan) digital media standard interface. Alternative embodiments contemplate other digital medial standard interfaces including but not limited to Compact Flash®, MulitMedia Card®, Secure Digital®, SmartMedia®, or any other removable portable device. The cartridge is of an ultra compact design that has a standard size and connectivity specifications based on the respective standard interface. The removable cartridge can be inserted into an
assay detector module 130 with a slot and connector corresponding to the standard for PC cards or Memory Stick Duo® detachable cartridge. - As used herein, the term “assay sensor” refers to a substrate or location for conducting body fluid analysis, such as but not limited to a biochemical assay. The
assay sensor module 120 provides an analytical testing platform for the fluid sample. In a non-binding embodiment, the sampling module and assay sensor are bundled together. Alternatively, the assay sensor may be a separate component. A sample is transported through the assay sensor module to particular assay sensors, through a network of microtubes using active or passive transport. -
FIG. 3 illustrates an embodiment of a configuration of multiple assay sensors and tubes for transport inassay sensor module 120.Assay sensor module 120 comprises acartridge 300, which containsmultiple assay sensors 400, each of which correspond to respective detectors (not shown) onanalytical detector module 130. Eachassay sensor 28 can perform the same analysis, for redundant testing, or a variety of different analysis using reagents stored inreservoirs 380 in thecartridge 300. These reagents are packaged in the cartridge during manufacture, such that the patient does not have to replenish any reagent to conduct the assay. Assay sensors may be chemically or biologically active locations. A number of different types of tests can be performed including blood chemistry, hematology, immuno-diagnostics those for drugs of abuse, serum cholesterol, glucose, FOBT, pregnancy, ovulation, along with many new types of analytics now being done in the DNA arena, such as DNA based assays, immuno assays, proteomics and genomics. These tests enableanalytical detector module 130 to detect characteristics, or information, about the fluid sample. As used herein, the term “information” refers to data determined as a result of analysis from the analytical testing conducted by the portable medical analyzer. - Blood coming into the cartridge via
sample acquisition port 340 is stored inreservoirs 420 so that it can accumulate to volumes appropriate for the relevant assay to be performed. Reagents necessary for the analysis are stored and shielded inreservoirs 380 prior to their use. A system of valves (not shown) keeps the reagents and sample fluid confined to appropriate paths in thecartridge 300. The blood and reagents are transported via active or passive transport throughmicro tubes 320 toassay sensors 420. Themicro tubes 320 may be forked to mix the blood and reagents prior to reachingassay sensors 400. Alternatively, the blood and reagents can mix upon contact with the assay sensor. - In the portable medical analyzer, the
AD module 130 evaluates the assay sensor in the assay sensor module via detectors, which are associated with the assay sensors. The AD generates signals corresponding to information or characteristics of the assay sensors. The AD module may include signal processing devices and circuitry for the rapid processing of the signals generated by the array of detectors, which correspond to the array of assays. A variety of detectors, including electrical, electrochemical, optical or mechanical can be used to detect results from tests on the assay sensor module. In one embodiment, the AD module can interface with a standard port on a portable computing device such as a laptop computer, a personal digital assistant (“PDA”), or other portable computing device, including but not limited to a Palm™ Handheld, Handspring™ Visor or Compaq iPAQ®. Standard ports include PCMCIA, serial, parallel, USB, IEEE 1394, and other computer connectivity standard ports. - A non-limiting embodiment of the
analytical detection module 130 contemplates a PC card platform, such as a Personal Computer Memory Card International Association (“PCMCIA”) card or Handspring™ Springboard™ Module. PC cards have standard thicknesses, design and pin assignments. The PC card physical characteristics include a 68 pin physical interface, length 85.6 mm, width 54.0 mm, and a thickness of either 3.3 mm, 5.0 mm, or 10.5 mm, depending on type. PC cards can include a slot for a Memory Stick® or other modular standard for sampling and assay sensor modules, thereby allowing detection and measurement of the assays on the PC card. In one embodiment, many different assays can be performed in the one detection area. The information detected by the analytical detectors contains results from each of these different assays. The thin versatile PC card will be able to both accept the cartridge and plug into a standard communication module for performing tests. - By virtue of the modularity of
assay sensing module 120, the analytical detector can be adapted for a wide variety of applications. In addition, by virtue of the modularity ofanalytical detector module 130, it can plug into a variety of host communication or computational platforms, ranging from PDAs to bench top systems. By utilizing the various combinations of assay sensors and analytical detectors, measurement systems can be configured that range from those suitable for personal use such a glucometer, to instruments for POC hospital application, or even laboratory measurements. - In the portable medical analyzer, a
communication module 140 can control both local (onboard) and remote (external) communication. The receiver can be adapted to receive instructions and/or data from external sources. The transmitter can be adapted to transfer the information read from the detector to external databases and systems in remote locations. Thecommunication module 140 can also comprise a display adapted to show the information read from the detector locally to a user via an LCD or other visual indicator. The remote transmission component can be a wireless component. Thecommunication module 140 plays the dual roles of controlling local and remote communication. - One embodiment of
communication module 140 can be a PDA, such as a Palm™ PDA, a Handspring™ Visor, or a Compaq iPac®.Communication module 140 can comprise of a standard PDA hardware and software including a processor, display, RF chip, antenna, and an operating system, which may be expanded by using some type of PC card technology. The PDA can be programmed with software to read information fromanalytical detector module 130, and transmit the information remotely using an industry standard protocol for communication of medical information. -
Communication module 140 can have a local storage unit in which the information collected can be stored, such as a localized RAM, i.e. DRAM containing a database of information. The information can also be sent to and stored on a remote database. The remote database can be part of Laboratory Information System, used to manage the information in central and reference laboratories. The remote database can display the information to a clinician, who in turn can analyze the information and send back to the user of the device instruction or comments on the results. Any of these functions can also be performed by a local database. In one embodiment, a communication module in a PDA can transmit and receive information through radio frequency (“RE”), infrared (“IR”), or docking on a cradle as is well known in the art of standard ports for computer peripherals. - In one embodiment, the communication module can direct information to a screen that displays test results to a user. In another embodiment, the module can direct information through a bi-directional wireless system. The
communication module 140 can communicate to the user, and communicate with an outside system as well. This connection can be made to a lab, a database, a clinical trial or a Laboratory Information System. The Laboratory Information System is an information management system. The term “information management system” refers to a system that can be used to manage the data between the portable medical analyzer and a centralized means for collecting and processing information for functions including but not limited to qualified user authentication, quality control, quality assurance, quality reporting, clinical processes, such as low impact on workflow, result review, decision support, and business processes (such as submitting information for billing generation, demonstrating cost-effectiveness, supporting practice guidelines, and direct marketing). The information and instructions transmitted to the portable medical analyzer can be directed to the particular user based on personal identification and security information. - Technically, the analyzer has many key features including reliability, security and confidentiality, content distribution, and functionality distribution (such as a application service provider). The analyzer can be connected to a central system, or it can stand alone. Once connected to a system, synchronization can take place. At the remote database end of the system, security and confidentiality are supported by creating authorization and authentication schemes to limit the access to data. The functionality distribution includes the creation of multi-tier disruption models, which may include localized computation or centralized server based computation. The functionality of the system is adaptive based on the availability of local or remote resources.
- In one embodiment, the data collected can be used for blind testing. A brokering system can be structured based on the collected personal medical records. The confidentiality of the system allows individuals to sell their medical data anonymously to customers. The customers can then use the data to develop medical technology or evaluate a heath care system.
- In another embodiment, a patient management system can be adapted to application distribution and information management. The system uses the portable medical analyzer and provides health care organizations with information integration and access to administrative, data management and decision support applications at the point of care.
- In another embodiment, the analyzer can be adapted to receive instructions from an administration system to automate processes such as calibration. The device can be in constant communication with a central hospital server system. At regular intervals the server can send a communication to the device that calibration is necessary. In one embodiment, the user can take a calibration cartridge and insert it into the device for calibration. The server can then either confirm that the device is calibrated or tell the user the device must be recalibrated manually.
- In another embodiment, the analyzer can be used for viewing of historical data such as previous results and patient trends. The analyzer can download past patient results, or store past patient results locally, and after testing show the patient not only the current results but also where they fall within historical trends.
- In another embodiment the analyzer can be a part of the Universal Connectivity Standard for Point-of-Care, for which further information may be forward at www.poccic.org. Using the connectivity standards, the device may be connected to both other devices and major medical or hospital systems. The communication can take place via an IR port, wireless networks or through connected phone lines.
- In another embodiment, an analyzer connected to an LIS can compare results from diagnostic tests run in the laboratory of full-size analyzers and develop correlation tables between results from the portable medical analyzer and the laboratory results.
-
FIG. 4 illustrates a flow diagram of an embodiment of a method for POC diagnosis using a portable medical analyzer as described inFIG. 1 .Sampling module 110 is integrated intoassay sensor module 120 in the form of a cartridge with a lancet. The user takes the cartridge and presses it against a finger. The driving mechanism trigger from the pressure of the trigger or a button on the analyzer. The driving mechanism propels the lancet, which lances the skin and draws body fluid (step 410). Once the cartridge is locked into analytical detector a pressure seal is broken causing calibration fluid, reagents and sampled body fluid to flow through the cartridge (step 420). The body fluid flows to the location of the assays on the cartridge, allowing for the chemical analysis by sensor and detection by detectors on the analytical detector module (step 430). - In another embodiment, the flow calibration fluid is simultaneously with body fluid sample.
Analytical detector 130 can be connected tocommunication module 140 through a standardized port. When connected, communication module can provide extra mechanical and electrical power toanalytical detector 130. Once powered,analytical detector 130 can quantify the results of the chemical analysis on the assay sensor module (step 440). The results are then transferred fromanalytical detector module 130 tocommunication module 140 through the standard pin connections (step 450).Communication module 140 can display the results locally for a user and/or transfer the results immediately or at a later time to a central database in a remote location. The entire process, from lancing to results may take as little as a few minutes. -
FIG. 5 illustrates an embodiment of the communication module within a network environment. An individual in ahome setting 510 with portablemedical analyzer 100 can use the analyzer to sample blood. Within the device a series of steps are performed to gather data. Once the data is gathered, it is wirelessly transmitted 520 through acommunication network 550 e.g. cellular, microwave, satellite, Internet, etc. to a remote system 570 in the hospital setting 560. The remote system can includecomputer 540 with a receiver and decoder that places the data into aremote database 530. Thecomputer 540 hosting the remote database can then process and display the information. Either a computer program or an operation at the computer terminal can send information back to the device, such as treatment information. Alternately, thecomputer 540 can be a network serveroperating communication network 550 as a Wide Area Network (WAN). -
FIG. 6 is a flow diagram illustrating amethod 600 of operation of an embodiment of a communication module within a network environment. Inmethod 600, once the analytical detector determines medical results (step 610), one or a combination (or more) of these steps can result. The results can be displayed locally (step 620), the results can be displayed remotely (step 625) or the results can be stored (step 630) either locally or remotely or both. If the results are displayed, this can be the end of the process, or then the results can be stored. Once the results are stored, the computer can process the results and create result trends (step 640). After the processing of trend results, the trends can be displayed locally, displayed remotely, or not displayed at all.Method 600 illustrates the various methods by which the analyzer can communicate and interact with a user and a network. - Although what has been described is aimed at analysis of body fluids, this concept is easily extended. Analytical detector modules could be developed to provide other diagnostic measurements such as ECG, or temperature etc. These measurements would then take advantage of the same communication module and communication network to transmit information.
- Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.
Claims (24)
1. A portable medical analyzer comprising:
a sampling module comprising a lancet, a driving mechanism, and a sample port, wherein said sampling port receives at least from a patient one body fluid from a tissue punctured with said lancet driven by said driving mechanism;
an assay sensor module housed in a cartridge, said cartridge comprising an interface with said sample port and at least one passage way to transport said body fluid to at least one assay sensor in said assay sensor module;
an analytical detector module comprising at least one analytical detector positioned to correspond to said assay sensor, said detector is adapted to detect information from said assay sensor; and
a communication module adapted to communicate with an information system at a remote location, the communication module configured to control local information from the analytical detector and at least a portion of information at the information system at the remote location.
2. A portable medical analyzer according to claim 1 , wherein:
said communication module comprises a transmitter adapted to transfer said information to a remote location.
3. A portable medical analyzer according to claim 1 , wherein:
said communication module comprises a receiver adapted to communicate with a remote location.
4. A portable medical analyzer according to claim 1 , wherein:
said sampling module is housed in said cartridge.
5. A portable medical analyzer according to claim 4 , wherein:
said analytical detector module is adapted to couple with said cartridge via a digital media standard interface.
6. A portable medical analyzer according to claim 1 , wherein:
said transmitter is adapted to at least one interface chosen from radio frequency, infrared and standard ports.
7. A portable medical analyzer according to claim 1 , further comprising:
an information storage unit for storing said information locally on said portable medical analyzer.
8. A method for portable medical analysis comprising:
obtaining a body fluid, wherein obtaining said body fluid comprises puncturing skin;
housing said body fluid within a cartridge comprising an assay sensor module;
positioning said cartridge into an analytical detector module;
obtaining information from said analytical detector module;
displaying said information locally on a display within a communication module; and
transferring said information to a remote location via said communication module, the communication module being adapted to communicate with an information system at the remote location, the communication module configured to control local information from the analytical detector and at least a portion of information at the information system at the remote location.
9. A portable medical analyzer comprising:
a sampling module comprising a sample port for receiving at least one body fluid via punctured skin, said sampling module housed in a cartridge;
an assay sensor module housed in said cartridge, said assay sensor module comprising at least one assay sensor adapted to at least one assay for said body fluid said cartridge comprising an interface with said sample port and at least one passage way to transport said body fluid to at least one assay sensor in said assay sensor module;
an analytical detector module comprising at least one signal processor and circuitry for processing of signals from at least one detector corresponding to said assay sensor, said detector adapted to detect information from said assay;
a communication module coupled to said signal processor, said communication module comprising a transmitter and receiver in communication with an information management system, the communication module configured to control local information from the analytical detector and at least a portion of information at the information system at the remote location.
10. A portable medical analyzer according to claim 9 , wherein:
said communication module is adapted to displaying said information locally on said portable medical analyzer.
11. A portable medical analyzer according to claim 9 , wherein:
said communication module is adapted to displaying historical data locally on portable medical analyzer.
12. A portable medical analyzer according to claim 9 , wherein:
said transmitter is adapted to at least one interface chosen from radio frequency, infrared and standard ports.
13. A portable medical analyzer according to claim 9 , wherein:
said transmitter is adapted to communicate with a remote database.
14. A portable medical analyzer according to claim 9 , wherein:
said communication module further comprises a storage unit for storing said information locally on said portable medical analyzer.
15. A portable medical analyzer according to claim 9 , wherein:
said information management system comprises a system for brokering medical data.
16. A portable medical analyzer according to claim 9 , wherein:
said information management system comprises a system for patient management.
17. A portable medical analyzer according to claim 9 , wherein:
said information management system comprises a system for administering said portable medical analyzer.
18. The portable medical analyzer of claim 1 , wherein the information system includes an external database.
19. The portable medical analyzer of claim 1 , wherein the communication module includes a receiver adapted to receive at least one of, instructions and data from the information system, the communication module further including a transmitter for transmitting information to the information system.
20. The portable medical analyzer of claim 1 , wherein the communication module includes a local storage unit where collected patient information can be stored.
21. The portable medical analyzer of claim 1 , wherein the portable medical analyzer is coupled to a remote database.
22. The portable medical analyzer of claim 1 , wherein the remote database is hosted by a computer that processes patient information.
23. The portable medical analyzer of claim 22 , wherein processed patient information is sent back to the patient.
24. The portable medical analyzer of claim 22 , wherein treatment information is sent from the remote site to the patient
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Cited By (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7875047B2 (en) | 2002-04-19 | 2011-01-25 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7901365B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909777B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909775B2 (en) | 2001-06-12 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US7909774B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7914465B2 (en) | 2002-04-19 | 2011-03-29 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7981055B2 (en) | 2001-06-12 | 2011-07-19 | Pelikan Technologies, Inc. | Tissue penetration device |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7988645B2 (en) | 2001-06-12 | 2011-08-02 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US8007446B2 (en) | 2002-04-19 | 2011-08-30 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8062231B2 (en) | 2002-04-19 | 2011-11-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8079960B2 (en) | 2002-04-19 | 2011-12-20 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8197421B2 (en) | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8251921B2 (en) | 2003-06-06 | 2012-08-28 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US8262614B2 (en) | 2003-05-30 | 2012-09-11 | Pelikan Technologies, Inc. | Method and apparatus for fluid injection |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US8296918B2 (en) | 2003-12-31 | 2012-10-30 | Sanofi-Aventis Deutschland Gmbh | Method of manufacturing a fluid sampling device with improved analyte detecting member configuration |
US8333710B2 (en) | 2002-04-19 | 2012-12-18 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US8382682B2 (en) | 2002-04-19 | 2013-02-26 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US20130066563A1 (en) * | 2011-09-09 | 2013-03-14 | Alverix, Inc. | Distributed network of in-vitro diagnostic devices |
US20130066562A1 (en) * | 2011-09-09 | 2013-03-14 | Alverix, Inc. | In-vitro diagnostic device using external information in conjunction with test results |
US8435190B2 (en) | 2002-04-19 | 2013-05-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8439872B2 (en) | 1998-03-30 | 2013-05-14 | Sanofi-Aventis Deutschland Gmbh | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8556829B2 (en) | 2002-04-19 | 2013-10-15 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US8721671B2 (en) | 2001-06-12 | 2014-05-13 | Sanofi-Aventis Deutschland Gmbh | Electric lancet actuator |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
WO2014150853A1 (en) * | 2013-03-15 | 2014-09-25 | Inanovate, Inc. | Analyte measurement using longitudinal assay |
WO2014150869A1 (en) * | 2013-03-15 | 2014-09-25 | Inanovate, Inc. | Cartridge device for processing time-resolved assays |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8975087B2 (en) | 2010-11-24 | 2015-03-10 | Inanovate, Inc. | Longitudinal assay |
US9144401B2 (en) | 2003-06-11 | 2015-09-29 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US11397181B2 (en) | 2016-06-22 | 2022-07-26 | Becton, Dickinson And Company | Modular assay reader device |
Families Citing this family (152)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2401046T3 (en) * | 1996-10-30 | 2013-04-16 | F.Hoffmann-La Roche Ag | Synchronized analyte test system |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
DE10057832C1 (en) * | 2000-11-21 | 2002-02-21 | Hartmann Paul Ag | Blood analysis device has syringe mounted in casing, annular mounting carrying needles mounted behind test strip and being swiveled so that needle can be pushed through strip and aperture in casing to take blood sample |
AU2002247008B2 (en) * | 2001-01-22 | 2006-02-09 | F. Hoffmann-La Roche Ag | Lancet device having capillary action |
ATE497731T1 (en) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | DEVICE FOR INCREASING THE SUCCESS RATE OF BLOOD YIELD OBTAINED BY A FINGER PICK |
CA2448905C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
US6966880B2 (en) * | 2001-10-16 | 2005-11-22 | Agilent Technologies, Inc. | Universal diagnostic platform |
US6989891B2 (en) | 2001-11-08 | 2006-01-24 | Optiscan Biomedical Corporation | Device and method for in vitro determination of analyte concentrations within body fluids |
DE10208575C1 (en) | 2002-02-21 | 2003-08-14 | Hartmann Paul Ag | Blood analyzer device comprises needles, test media, analyzer and display, and has carrier turned with respect to main body, to position needle and test media |
US7130835B2 (en) * | 2002-03-28 | 2006-10-31 | Bausch & Lomb Incorporated | System and method for predictive ophthalmic correction |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
DE10226212A1 (en) * | 2002-06-13 | 2003-12-24 | Philips Intellectual Property | Qualifying Examination System |
US7267799B1 (en) | 2002-08-14 | 2007-09-11 | Detekt Biomedical, L.L.C. | Universal optical imaging and processing system |
US7803322B2 (en) | 2002-08-14 | 2010-09-28 | Detekt Biomedical, L.L.C. | Universal optical imaging and processing system |
US20040102717A1 (en) * | 2002-11-26 | 2004-05-27 | Yan Qi | Disposable automatic safety assembly means for test and/or delivery |
US20040249254A1 (en) * | 2003-06-06 | 2004-12-09 | Joel Racchini | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
US7258673B2 (en) * | 2003-06-06 | 2007-08-21 | Lifescan, Inc | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
US20040253736A1 (en) * | 2003-06-06 | 2004-12-16 | Phil Stout | Analytical device with prediction module and related methods |
US7604592B2 (en) | 2003-06-13 | 2009-10-20 | Pelikan Technologies, Inc. | Method and apparatus for a point of care device |
US7678127B2 (en) * | 2003-08-20 | 2010-03-16 | Facet Technologies, Llc | Multi-lancet device with sterility cap repositioning mechanism |
CA2896407A1 (en) * | 2003-09-11 | 2005-03-24 | Theranos, Inc. | Medical device for analyte monitoring and drug delivery |
DE10344262A1 (en) * | 2003-09-23 | 2005-04-14 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Plug-in module for a liquid or gas sensor |
US7179233B2 (en) * | 2003-10-31 | 2007-02-20 | Yu-Hong Chang | Compact structure of a new biosensor monitor |
WO2005046477A2 (en) * | 2003-11-12 | 2005-05-26 | Facet Technologies, Llc | Lancing device and multi-lancet cartridge |
JP2007534363A (en) * | 2003-12-18 | 2007-11-29 | インバーネス メディカル スウィッツァーランド ゲーエムベーハー | Monitoring method and monitoring apparatus |
GB0329288D0 (en) * | 2003-12-18 | 2004-01-21 | Inverness Medical Switzerland | Monitoring method and apparatus |
DE102004002874A1 (en) * | 2004-01-20 | 2005-08-11 | Roche Diagnostics Gmbh | Analyzer for analysis of blood samples |
US20060292040A1 (en) * | 2005-06-16 | 2006-12-28 | James Wickstead | Hand held test reader |
US20080312555A1 (en) * | 2004-02-06 | 2008-12-18 | Dirk Boecker | Devices and methods for glucose measurement using rechargeable battery energy sources |
US7819822B2 (en) * | 2004-03-06 | 2010-10-26 | Roche Diagnostics Operations, Inc. | Body fluid sampling device |
PL1725168T3 (en) * | 2004-03-06 | 2016-10-31 | Body fluid sampling device | |
US20070143035A1 (en) * | 2005-12-19 | 2007-06-21 | Petruno Patrick T | Diagnostic test reader with disabling unit |
US20070185679A1 (en) * | 2004-04-01 | 2007-08-09 | Petruno Patrick T | Indicating status of a diagnostic test system |
US8128871B2 (en) | 2005-04-22 | 2012-03-06 | Alverix, Inc. | Lateral flow assay systems and methods |
JP4944770B2 (en) | 2004-04-16 | 2012-06-06 | ファセット・テクノロジーズ・エルエルシー | Cap displacement mechanism for puncture device and multi-lancet cartridge |
US20050283319A1 (en) * | 2004-06-16 | 2005-12-22 | International Business Machines Corporation | Method, system, and apparatus for detecting biological agents with a portable computing device |
US8343074B2 (en) * | 2004-06-30 | 2013-01-01 | Lifescan Scotland Limited | Fluid handling devices |
US7837633B2 (en) | 2004-06-30 | 2010-11-23 | Facet Technologies, Llc | Lancing device and multi-lancet cartridge |
US7358998B2 (en) * | 2004-07-01 | 2008-04-15 | Asia Optical Co., Inc. | Image switching apparatus providing an optical compensator |
US20070255300A1 (en) * | 2004-08-19 | 2007-11-01 | Facet Technologies, Llc | Loosely coupled lancet |
US20060085162A1 (en) * | 2004-10-15 | 2006-04-20 | Bjornson Torleif O | Laboratory sample transfer apparatus with interchangeable tools |
WO2006065708A1 (en) * | 2004-12-13 | 2006-06-22 | Bayer Healthcare Llc | Mains-powered integrated-diagnostic instrument |
US7833189B2 (en) | 2005-02-11 | 2010-11-16 | Massachusetts Institute Of Technology | Controlled needle-free transport |
US20070083160A1 (en) * | 2005-10-06 | 2007-04-12 | Hall W D | System and method for assessing measurements made by a body fluid analyzing device |
US20060235348A1 (en) | 2005-02-14 | 2006-10-19 | Callicoat David N | Method of extracting and analyzing the composition of bodily fluids |
US8936755B2 (en) | 2005-03-02 | 2015-01-20 | Optiscan Biomedical Corporation | Bodily fluid composition analyzer with disposable cassette |
US8251907B2 (en) | 2005-02-14 | 2012-08-28 | Optiscan Biomedical Corporation | System and method for determining a treatment dose for a patient |
US8956291B2 (en) * | 2005-02-22 | 2015-02-17 | Admetsys Corporation | Balanced physiological monitoring and treatment system |
US8206650B2 (en) * | 2005-04-12 | 2012-06-26 | Chromedx Inc. | Joint-diagnostic spectroscopic and biosensor meter |
US20100245803A1 (en) * | 2005-04-12 | 2010-09-30 | Chromedx Inc. | Blood sample holder for spectroscopic analysis |
CA2517299A1 (en) * | 2005-08-26 | 2007-02-26 | Chromedx Inc. | Hollow needle assembly |
US7740804B2 (en) * | 2005-04-12 | 2010-06-22 | Chromedx Inc. | Spectroscopic sample holder |
CA2507323A1 (en) * | 2005-05-13 | 2006-11-13 | Chromedx Inc. | Diagnostic whole blood and plasma apparatus |
US9891217B2 (en) | 2005-04-22 | 2018-02-13 | Alverix, Inc. | Assay test strips with multiple labels and reading same |
US20070026426A1 (en) * | 2005-04-26 | 2007-02-01 | Applera Corporation | System for genetic surveillance and analysis |
ES2820430T3 (en) * | 2005-05-09 | 2021-04-21 | Labrador Diagnostics Llc | Fluid systems for care centers and their uses |
US8636672B2 (en) * | 2007-02-28 | 2014-01-28 | Nipro Diagnostics, Inc. | Test strip with integrated lancet |
US20070035403A1 (en) * | 2005-08-12 | 2007-02-15 | Krishna Sudhir S | Method and system of personal healthcare management |
US7775991B2 (en) | 2005-08-31 | 2010-08-17 | Kimberly-Clark Worldwide, Inc. | Device for sampling blood |
US8597208B2 (en) * | 2005-09-06 | 2013-12-03 | Covidien Lp | Method and apparatus for measuring analytes |
EP1931257A4 (en) * | 2005-09-06 | 2009-08-26 | Nir Diagnostics Inc | Method and apparatus for measuring analytes |
WO2007037949A2 (en) * | 2005-09-27 | 2007-04-05 | Bayer Healthcare Llc | Flip-top integrated-diagnostic instrument |
US9561001B2 (en) | 2005-10-06 | 2017-02-07 | Optiscan Biomedical Corporation | Fluid handling cassette system for body fluid analyzer |
US8057404B2 (en) * | 2005-10-12 | 2011-11-15 | Panasonic Corporation | Blood sensor, blood testing apparatus, and method for controlling blood testing apparatus |
US20070081920A1 (en) * | 2005-10-12 | 2007-04-12 | Murphy R S | Semi-disposable optoelectronic rapid diagnostic test system |
US20070119928A1 (en) * | 2005-11-17 | 2007-05-31 | Jung Edward K | Generating a nutraceutical request from an inventory |
US8532938B2 (en) * | 2005-11-17 | 2013-09-10 | The Invention Science Fund I, Llc | Testing-dependent administration of a nutraceutical |
US10042980B2 (en) | 2005-11-17 | 2018-08-07 | Gearbox Llc | Providing assistance related to health |
US20070299693A1 (en) * | 2006-06-23 | 2007-12-27 | Searete Llc, A Limited Liability Corporation | Customized visual marking for medication labeling |
US20070124219A1 (en) * | 2005-11-30 | 2007-05-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational and/or control systems related to individualized nutraceutical selection and packaging |
US20080082272A1 (en) * | 2005-11-30 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems and methods related to nutraceuticals |
US20080103746A1 (en) * | 2005-11-30 | 2008-05-01 | Searete Llc, A Limited Liability Corporation | Systems and methods for pathogen detection and response |
US20080114577A1 (en) * | 2005-11-30 | 2008-05-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems associated with nutraceutical related assays |
US20070124175A1 (en) * | 2005-11-30 | 2007-05-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware. | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
US7827042B2 (en) | 2005-11-30 | 2010-11-02 | The Invention Science Fund I, Inc | Methods and systems related to transmission of nutraceutical associated information |
US7974856B2 (en) * | 2005-11-30 | 2011-07-05 | The Invention Science Fund I, Llc | Computational systems and methods related to nutraceuticals |
US8000981B2 (en) | 2005-11-30 | 2011-08-16 | The Invention Science Fund I, Llc | Methods and systems related to receiving nutraceutical associated information |
US10296720B2 (en) | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
US7927787B2 (en) * | 2006-06-28 | 2011-04-19 | The Invention Science Fund I, Llc | Methods and systems for analysis of nutraceutical associated components |
US20080033763A1 (en) * | 2005-11-30 | 2008-02-07 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems related to receiving nutraceutical associated information |
US8340944B2 (en) * | 2005-11-30 | 2012-12-25 | The Invention Science Fund I, Llc | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
US8297028B2 (en) | 2006-06-14 | 2012-10-30 | The Invention Science Fund I, Llc | Individualized pharmaceutical selection and packaging |
US20110145009A1 (en) * | 2005-11-30 | 2011-06-16 | Jung Edward K Y | Methods and systems related to transmission of nutraceutical associatd information |
US7998087B2 (en) * | 2006-01-31 | 2011-08-16 | Panasonic Corporation | Blood test apparatus and blood test method |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
US20090093735A1 (en) * | 2006-03-29 | 2009-04-09 | Stephan Korner | Test unit and test system for analyzing body fluids |
EP2000807B1 (en) * | 2006-03-29 | 2013-04-24 | Konica Minolta Medical & Graphic, Inc. | Method of reaction in microchip channel and analyzer |
US8696597B2 (en) * | 2006-04-03 | 2014-04-15 | Nipro Diagnostics, Inc. | Diagnostic meter |
US7939021B2 (en) * | 2007-05-09 | 2011-05-10 | Advanced Liquid Logic, Inc. | Droplet actuator analyzer with cartridge |
US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
US20080091470A1 (en) * | 2006-06-01 | 2008-04-17 | Igeacare Systems Inc. | Remote health care diagnostic tool |
US20080077435A1 (en) * | 2006-06-01 | 2008-03-27 | Igeacare Systems Inc. | Remote health care system with stethoscope |
US20080076973A1 (en) * | 2006-06-01 | 2008-03-27 | Igeacare Systems Inc. | Remote health care system with treatment verification |
EP2041524A4 (en) * | 2006-07-13 | 2011-11-23 | I Stat Corp | Medical data acquisition and patient management system and method |
EP2057572B1 (en) * | 2006-08-16 | 2021-04-14 | Sime Diagnostics Ltd. | An interactive testing system for analysing biological samples. |
WO2008034102A2 (en) * | 2006-09-15 | 2008-03-20 | Haemonetics Corporation | Surface mapping by optical manipulation of particles in relation to a functionalized surface |
US20080081002A1 (en) * | 2006-09-29 | 2008-04-03 | Patrick Petruno | Diagnostic assay reader having multiple power configurations |
US8012744B2 (en) | 2006-10-13 | 2011-09-06 | Theranos, Inc. | Reducing optical interference in a fluidic device |
US20080113391A1 (en) | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
CA2580589C (en) | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
EP2101654A4 (en) | 2007-01-12 | 2013-03-06 | Facet Technologies Llc | Multi-lancet cartridge and lancing device |
US8506908B2 (en) * | 2007-03-09 | 2013-08-13 | Vantix Holdings Limited | Electrochemical detection system |
WO2008112635A1 (en) * | 2007-03-09 | 2008-09-18 | Dxtech, Llc | Multi-channel lock-in amplifier system and method |
WO2008119184A1 (en) | 2007-04-02 | 2008-10-09 | Fio Corporation | System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology |
US8597190B2 (en) | 2007-05-18 | 2013-12-03 | Optiscan Biomedical Corporation | Monitoring systems and methods with fast initialization |
US20080311953A1 (en) * | 2007-06-13 | 2008-12-18 | Ein-Yiao Shen | Mobile communication device with combinative body function detecting modules |
EP2015067A1 (en) * | 2007-06-15 | 2009-01-14 | Roche Diagnostics GmbH | System for measuring the analyte concentration in a body fluid sample |
CN101821322B (en) | 2007-06-22 | 2012-12-05 | Fio公司 | Systems and methods for manufacturing quantum dot-doped polymer microbeads |
WO2009006739A1 (en) | 2007-07-09 | 2009-01-15 | Fio Corporation | Systems and methods for enhancing fluorescent detection of target molecules in a test sample |
US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
NZ584963A (en) | 2007-10-02 | 2012-11-30 | Theranos Inc | Modular Point-of-care devices as addressible assay units with tips of assay units having interior to immobilize reagents by capillary action |
WO2009049245A1 (en) * | 2007-10-11 | 2009-04-16 | Optiscan Biomedical Corporation | Synchronization and configuration of patient monitoring devices |
CN101861203B (en) | 2007-10-12 | 2014-01-22 | Fio公司 | Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto |
US7766846B2 (en) | 2008-01-28 | 2010-08-03 | Roche Diagnostics Operations, Inc. | Rapid blood expression and sampling |
BRPI0906017A2 (en) * | 2008-02-27 | 2015-06-30 | Mond4D Ltd | System and device for measuring an analyte from a body fluid over a measuring area, device for controlling an analyte measuring device, method for measuring an analyte from a body fluid, system for monitoring an analyte from a body fluid , specialized analyte measuring element and vehicle |
WO2009155704A1 (en) | 2008-06-25 | 2009-12-30 | Fio Corporation | Bio-threat alert system |
US20110137208A1 (en) * | 2008-07-24 | 2011-06-09 | Admetsys Corporation | Device and method for automatically sampling and measuring blood analytes |
MX2011002235A (en) | 2008-08-29 | 2011-04-05 | Fio Corp | A single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples. |
CA2749660C (en) | 2009-01-13 | 2017-10-31 | Fio Corporation | A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test |
US8160572B2 (en) * | 2009-01-30 | 2012-04-17 | Oracle International Corporation | Platform test environment and unit test framework for a telecommunications gateway |
US20100234708A1 (en) * | 2009-03-16 | 2010-09-16 | Harvey Buck | Wirelessly configurable medical device for a broadcast network system |
US8928877B2 (en) | 2011-07-06 | 2015-01-06 | Optiscan Biomedical Corporation | Sample cell for fluid analysis system |
US9554742B2 (en) | 2009-07-20 | 2017-01-31 | Optiscan Biomedical Corporation | Fluid analysis system |
WO2011011462A1 (en) | 2009-07-20 | 2011-01-27 | Optiscan Biomedical Corporation | Adjustable connector and dead space reduction |
US8758271B2 (en) | 2009-09-01 | 2014-06-24 | Massachusetts Institute Of Technology | Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties |
PL2482870T3 (en) | 2009-09-29 | 2018-05-30 | Admetsys Corporation | System and method for differentiating containers in medication delivery |
KR101875858B1 (en) | 2009-10-19 | 2018-07-06 | 테라노스, 인코포레이티드 | Integrated health data capture and analysis system |
WO2011048200A2 (en) * | 2009-10-22 | 2011-04-28 | Roche Diagnostics Gmbh | Micro-capillary system having increased sample volume |
WO2011084511A1 (en) * | 2009-12-15 | 2011-07-14 | Massachusetts Institute Of Technology | Jet injector use in oral evaluation |
US10867701B1 (en) * | 2010-06-28 | 2020-12-15 | Heinrich Anhold | System and method for optimizing patient-specific intervention strategies using point of care diagnostics |
DE102010047828A1 (en) * | 2010-10-04 | 2012-04-05 | Eppendorf Ag | Laboratory device for treating liquids |
EP2693215A4 (en) * | 2011-03-31 | 2014-12-24 | Terumo Corp | Blood-glucose level management system |
US10240186B2 (en) * | 2011-07-14 | 2019-03-26 | Fluxion Biosciences, Inc. | Devices, systems, and methods for magnetic separation |
TWI524202B (en) * | 2011-08-30 | 2016-03-01 | 華晶科技股份有限公司 | Electric device with data detection function and data detection method thereof |
KR102168912B1 (en) | 2012-03-16 | 2020-10-23 | 스타트-다이아그노스티카 앤드 이노베이션, 에스.엘. | A test cartridge with integrated transfer module |
WO2014042685A1 (en) * | 2012-09-13 | 2014-03-20 | Triton Systems, Inc. | Methods and systems for monitoring and controlling electronic devices |
CN103279665A (en) * | 2013-05-29 | 2013-09-04 | 美合实业(苏州)有限公司 | Multi-user and multi-parameter wireless detection, diagnosis, service and monitoring method |
WO2015095239A1 (en) | 2013-12-18 | 2015-06-25 | Optiscan Biomedical Corporation | Systems and methods for detecting leaks |
WO2015161291A1 (en) | 2014-04-17 | 2015-10-22 | Church & Dwight Co., Inc. | Electronic test device data communication |
WO2016161081A1 (en) | 2015-04-03 | 2016-10-06 | Fluxion Biosciences, Inc. | Molecular characterization of single cells and cell populations for non-invasive diagnostics |
WO2016201193A1 (en) * | 2015-06-11 | 2016-12-15 | MeasureMeNow, Inc. | Self-operating and transportable remote lab system |
US10950341B2 (en) * | 2015-11-30 | 2021-03-16 | Physio-Control, Inc. | Integration of a point-of-care blood analyzer into a prehospital telemedicine system |
US9682378B1 (en) * | 2015-12-08 | 2017-06-20 | Paratus Diagnostics, LLC | Mating adaptor for coupling a point-of-care diagnostic cartridge to a computing device |
US10436781B2 (en) | 2016-01-27 | 2019-10-08 | Paratus Diagnostics, LLC | Point-of-care diagnostic cartridge having a digital micro-fluidic testing substrate |
US20180117586A1 (en) * | 2016-11-02 | 2018-05-03 | Danson Evan Lu Garcia | Modular electrochemical and/or bioassay sensing platform and control thereof |
US9719892B1 (en) | 2017-01-30 | 2017-08-01 | Paratus Diagnostic, Llc | Processing device for processing a highly viscous sample |
CN107874767B (en) * | 2017-10-12 | 2020-11-24 | 杭州博拓生物科技股份有限公司 | Device for detecting analyzed substance in sample |
WO2021245565A1 (en) * | 2020-06-02 | 2021-12-09 | Nucleolife Laboratory (Pty) Ltd | Nucleodx rapid test |
Citations (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2880876A (en) * | 1954-10-02 | 1959-04-07 | Melotte Ecremeuses | Apparatus for separating a liquid from an overlying layer of foam |
US3063451A (en) * | 1959-09-28 | 1962-11-13 | Arthur J Kowalk | Self-venting type needle |
US3090384A (en) * | 1960-04-15 | 1963-05-21 | Mfg Process Lab Inc | Needle |
US3424154A (en) * | 1965-11-08 | 1969-01-28 | Charles W Kinsley | Injection system |
US3607097A (en) * | 1967-08-09 | 1971-09-21 | Philips Corp | Analyzer for liquid samples |
US4525164A (en) * | 1981-04-24 | 1985-06-25 | Biotek, Inc. | Wearable medication infusion system with arcuated reservoir |
US4586926A (en) * | 1984-03-05 | 1986-05-06 | Cook, Incorporated | Percutaneous entry needle |
US4627445A (en) * | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
US4661768A (en) * | 1983-09-14 | 1987-04-28 | Johnson Service Company | Capacitance transducing method and apparatus |
US4695273A (en) * | 1986-04-08 | 1987-09-22 | I-Flow Corporation | Multiple needle holder and subcutaneous multiple channel infusion port |
US4757022A (en) * | 1986-04-15 | 1988-07-12 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
US4787398A (en) * | 1985-04-08 | 1988-11-29 | Garid, Inc. | Glucose medical monitoring system |
US5029583A (en) * | 1986-07-22 | 1991-07-09 | Personal Diagnostics, Inc. | Optical analyzer |
US5064411A (en) * | 1988-11-04 | 1991-11-12 | Gordon Iii Kilbourn | Protective medical device |
US5104382A (en) * | 1991-01-15 | 1992-04-14 | Ethicon, Inc. | Trocar |
US5163442A (en) * | 1991-07-30 | 1992-11-17 | Harry Ono | Finger tip blood collector |
US5208163A (en) * | 1990-08-06 | 1993-05-04 | Miles Inc. | Self-metering fluid analysis device |
US5217476A (en) * | 1991-10-01 | 1993-06-08 | Medical Sterile Products, Inc. | Surgical knife blade and method of performing cataract surgery utilizing a surgical knife blade |
US5279294A (en) * | 1985-04-08 | 1994-01-18 | Cascade Medical, Inc. | Medical diagnostic system |
WO1996012546A1 (en) * | 1994-10-19 | 1996-05-02 | Hewlett-Packard Company | Miniaturized planar columns for use in a liquid phase separation apparatus |
US5700695A (en) * | 1994-06-30 | 1997-12-23 | Zia Yassinzadeh | Sample collection and manipulation method |
US5772586A (en) * | 1996-02-12 | 1998-06-30 | Nokia Mobile Phones, Ltd. | Method for monitoring the health of a patient |
US5827179A (en) * | 1997-02-28 | 1998-10-27 | Qrs Diagnostic, Llc | Personal computer card for collection for real-time biological data |
US5858195A (en) * | 1994-08-01 | 1999-01-12 | Lockheed Martin Energy Research Corporation | Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis |
US5871494A (en) * | 1997-12-04 | 1999-02-16 | Hewlett-Packard Company | Reproducible lancing for sampling blood |
US5873856A (en) * | 1995-06-22 | 1999-02-23 | Pharmacia Ab | Limited depth penetration needle housing |
US5892569A (en) * | 1996-11-22 | 1999-04-06 | Jozef F. Van de Velde | Scanning laser ophthalmoscope optimized for retinal microphotocoagulation |
US5917429A (en) * | 1992-09-14 | 1999-06-29 | Aprex Corporation | Contactless communication system |
US5940153A (en) * | 1998-04-03 | 1999-08-17 | Motorola, Inc. | Display assembly having LCD and seal captured between interlocking lens cover and lightpipe |
US5938635A (en) * | 1996-12-30 | 1999-08-17 | Kuhle; William G. | Biopsy needle with flared tip |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5950632A (en) * | 1997-03-03 | 1999-09-14 | Motorola, Inc. | Medical communication apparatus, system, and method |
US5961451A (en) * | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
US6071294A (en) * | 1997-12-04 | 2000-06-06 | Agilent Technologies, Inc. | Lancet cartridge for sampling blood |
US6093156A (en) * | 1996-12-06 | 2000-07-25 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
US6102872A (en) * | 1997-11-03 | 2000-08-15 | Pacific Biometrics, Inc. | Glucose detector and method |
US6117115A (en) * | 1998-10-12 | 2000-09-12 | B. Braun Medical, Inc. | Medical tubing slide clamp device for determining proper tubing size and functional characteristics |
US6144976A (en) * | 1993-02-26 | 2000-11-07 | Norand Corporation | Hand-held data collection computer terminal having power management architecture including switchable multi-purpose input display screen |
US6149787A (en) * | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
US6172743B1 (en) * | 1992-10-07 | 2001-01-09 | Chemtrix, Inc. | Technique for measuring a blood analyte by non-invasive spectrometry in living tissue |
DE19928412A1 (en) * | 1999-06-22 | 2001-01-11 | Agilent Technologies Inc | Supply system to prepare a microchip with a microfluid structure has a sealed supply for the material which is penetrated on contact with the microchip and further supplies to give the material a movement potential on the microchip |
US6183442B1 (en) * | 1998-03-02 | 2001-02-06 | Board Of Regents Of The University Of Texas System | Tissue penetrating device and methods for using same |
US6200289B1 (en) * | 1998-04-10 | 2001-03-13 | Milestone Scientific, Inc. | Pressure/force computer controlled drug delivery system and the like |
US6224617B1 (en) * | 1997-10-17 | 2001-05-01 | Angiotrax, Inc. | Methods and apparatus for defibrillating a heart refractory to electrical stimuli |
US20010018353A1 (en) * | 2000-02-29 | 2001-08-30 | Matsushita Electric Industrial Co., Ltd. | Portable telephone with bookmark sort function |
US6309370B1 (en) * | 1998-02-05 | 2001-10-30 | Biosense, Inc. | Intracardiac drug delivery |
US20010037072A1 (en) * | 1998-08-24 | 2001-11-01 | Virtanen Jorma A. | Cassette and applicator for biological and chemical sample collection |
US20020020646A1 (en) * | 2000-06-09 | 2002-02-21 | Groth Lars Morch | Needle magazine |
US6358196B1 (en) * | 1999-12-29 | 2002-03-19 | Reiza Rayman | Magnetic retraction system for laparoscopic surgery and method of use thereof |
US6375626B1 (en) * | 1999-03-12 | 2002-04-23 | Integ, Inc. | Collection well for body fluid tester |
US20020058902A1 (en) * | 2000-05-01 | 2002-05-16 | Nikiforos Kollias | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
US6419661B1 (en) * | 1999-03-05 | 2002-07-16 | Roche Diagnostics Gmbh | Device for withdrawing blood for diagnostic applications |
US20020109600A1 (en) * | 2000-10-26 | 2002-08-15 | Mault James R. | Body supported activity and condition monitor |
US20020111634A1 (en) * | 2000-08-30 | 2002-08-15 | Johns Hopkins University | Controllable motorized device for percutaneous needle placement in soft tissue target and methods and systems related thereto |
US6447119B1 (en) * | 1996-08-12 | 2002-09-10 | Visionrx, Inc. | Apparatus for visualizing the eye's tear film |
US20020156355A1 (en) * | 2001-02-15 | 2002-10-24 | Gough David A. | Membrane and electrode structure for implantable sensor |
US6537264B1 (en) * | 1996-06-18 | 2003-03-25 | Alza Corp | Device and method for enhancing transdermal flux of agents being sampled |
US20030069509A1 (en) * | 2001-10-10 | 2003-04-10 | David Matzinger | Devices for physiological fluid sampling and methods of using the same |
US20030092982A1 (en) * | 1999-08-12 | 2003-05-15 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6579690B1 (en) * | 1997-12-05 | 2003-06-17 | Therasense, Inc. | Blood analyte monitoring through subcutaneous measurement |
US6591124B2 (en) * | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US20030136189A1 (en) * | 2002-01-22 | 2003-07-24 | Brian Lauman | Capacitance fluid volume measurement |
US6599281B1 (en) * | 2000-05-03 | 2003-07-29 | Aspect Medical Systems, Inc. | System and method for adaptive drug delivery |
US20030211619A1 (en) * | 2002-05-09 | 2003-11-13 | Lorin Olson | Continuous strip of fluid sampling and testing devices and methods of making, packaging and using the same |
US20040068093A1 (en) * | 2002-07-01 | 2004-04-08 | The Procter & Gamble Company | Polymerized hydrogel comprising low amounts of residual monomers and by-products |
US20040065669A1 (en) * | 2002-06-25 | 2004-04-08 | Giraud Jean Pierre | Moisture-proof resealable, non-cylindrical container for consumer packages |
US20040068283A1 (en) * | 2001-01-12 | 2004-04-08 | Masahiro Fukuzawa | Puncturing device |
US6729546B2 (en) * | 1994-10-26 | 2004-05-04 | Symbol Technologies, Inc. | System for reading two-dimensional images using ambient and/or projected light |
US6808499B1 (en) * | 2000-09-29 | 2004-10-26 | University Of Vermont | Therapeutic and diagnostic needling device and method |
US20050187442A1 (en) * | 2004-02-24 | 2005-08-25 | Ok-Kyung Cho | Blood sugar level measuring apparatus |
USRE38803E1 (en) * | 1995-01-25 | 2005-09-27 | Robert E. Rodgers, Jr. | Stationary exercise apparatus having a preferred foot platform path |
US6966880B2 (en) * | 2001-10-16 | 2005-11-22 | Agilent Technologies, Inc. | Universal diagnostic platform |
US20060100542A9 (en) * | 2004-04-15 | 2006-05-11 | Daniel Wong | Integrated spot monitoring device with fluid sensor |
US20060222566A1 (en) * | 2003-08-01 | 2006-10-05 | Brauker James H | Transcutaneous analyte sensor |
US20060229652A1 (en) * | 2003-07-31 | 2006-10-12 | Matsushita Electric Industrial Co., Ltd | Puncturing instrument, puncturing needle cartridge, puncturing instrument set, and puncturing needle discardment instrument |
US20060234263A1 (en) * | 2005-03-10 | 2006-10-19 | Gen-Probe Incorporated | Method for reducing the presence of amplification inhibitors in a reaction receptacle |
US20070118051A1 (en) * | 2004-04-10 | 2007-05-24 | Stephan Korner | Method and system for withdrawing body fluid |
US20070123803A1 (en) * | 2005-10-12 | 2007-05-31 | Masaki Fujiwara | Blood sensor, blood testing apparatus, and method for controlling blood testing apparatus |
US20070142748A1 (en) * | 2002-04-19 | 2007-06-21 | Ajay Deshmukh | Tissue penetration device |
US20080042594A1 (en) * | 2004-06-30 | 2008-02-21 | Daniel Lopez | Power Supply for a Metal Vapour Lamp |
US20080047764A1 (en) * | 2006-08-28 | 2008-02-28 | Cypress Semiconductor Corporation | Temperature compensation method for capacitive sensors |
US20080255598A1 (en) * | 2003-08-20 | 2008-10-16 | Facet Technologies, Llc | Lancing Device With Replaceable Multi-Lancet Carousel |
US20090076415A1 (en) * | 2000-06-09 | 2009-03-19 | Piet Moerman | Cap for a Lancing Device |
US20090099477A1 (en) * | 2007-10-15 | 2009-04-16 | Joachim Hoenes | Lancet wheel |
US20090112247A1 (en) * | 2002-04-19 | 2009-04-30 | Dominique Freeman | Method and apparatus for penetrating tissue |
US20090119760A1 (en) * | 2007-11-06 | 2009-05-07 | National Tsing Hua University | Method for reconfiguring security mechanism of a wireless network and the mobile node and network node thereof |
US20090118752A1 (en) * | 2001-06-08 | 2009-05-07 | Edward Perez | Devices and methods for expression of bodily fluids from an incision |
US20090177117A1 (en) * | 2006-01-31 | 2009-07-09 | Matsushita Electric Industrial Co., Ltd. | Blood test method and blood test apparatus |
US20090270765A1 (en) * | 2005-11-30 | 2009-10-29 | Abbott Diabetes Care Inc. | Integrated meter for analyzing biological samples |
US7645263B2 (en) * | 2001-10-26 | 2010-01-12 | Massachusetts Institute Of Technology | Impedance sensor |
US20100094324A1 (en) * | 2008-10-14 | 2010-04-15 | Bionime Corporation | Lancing device |
US20100113981A1 (en) * | 2008-05-09 | 2010-05-06 | Panasonic Corporation | Skin incision instrument and method for incising skin with the same |
US7713214B2 (en) * | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
US20100131440A1 (en) * | 2008-11-11 | 2010-05-27 | Nec Laboratories America Inc | Experience transfer for the configuration tuning of large scale computing systems |
US7749174B2 (en) * | 2001-06-12 | 2010-07-06 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge |
US20100256525A1 (en) * | 2007-04-18 | 2010-10-07 | Hans List | Lancing and analysis device |
US20100274273A1 (en) * | 2007-06-19 | 2010-10-28 | Steven Schraga | Lancet device with depth adjustment and lancet removal system and method |
US7879058B2 (en) * | 2004-04-26 | 2011-02-01 | Asahi Polyslider Company, Limted | Lancet device for forming incision |
US7901365B2 (en) * | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20110077478A1 (en) * | 2002-04-19 | 2011-03-31 | Dominique Freeman | Body fluid sampling module with a continuous compression tissue interface surface |
US20110077553A1 (en) * | 2001-11-27 | 2011-03-31 | Shl Telemedicine International Ltd. | Device for sampling blood droplets under vacuum conditions |
US7976778B2 (en) * | 2001-04-02 | 2011-07-12 | Abbott Diabetes Care Inc. | Blood glucose tracking apparatus |
US20110178429A1 (en) * | 2010-01-19 | 2011-07-21 | Jacobs Christopher A | Vacuum assisted lancing system and method for blood extraction with minimal pain |
US20110184448A1 (en) * | 2008-06-05 | 2011-07-28 | Bayer Healthcare Llc | Lancing device |
US8197421B2 (en) * | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20120149999A1 (en) * | 2001-06-12 | 2012-06-14 | Dominique Freeman | Tissue penetration device |
US8231548B2 (en) * | 2006-07-18 | 2012-07-31 | Roche Diagnostics Operations, Inc. | Portable measuring system having a moisture-proof assembly space |
US8251922B2 (en) * | 2007-10-08 | 2012-08-28 | Roche Diagnostics Operations, Inc. | Analysis system for automatic skin prick analysis |
US8282576B2 (en) * | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US20120271197A1 (en) * | 2010-06-02 | 2012-10-25 | Mark Castle | Methods and apparatus for lancet actuation |
US8388639B2 (en) * | 2007-08-14 | 2013-03-05 | Owen Mumford Limited | Lancing devices |
US8491500B2 (en) * | 2002-04-19 | 2013-07-23 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5935099A (en) * | 1992-09-09 | 1999-08-10 | Sims Deltec, Inc. | Drug pump systems and methods |
US4731726A (en) * | 1986-05-19 | 1988-03-15 | Healthware Corporation | Patient-operated glucose monitor and diabetes management system |
FI87133C (en) * | 1989-03-23 | 1992-12-10 | David Fitness & Medical Ltd Oy | FOERFARANDE FOER MAETNING AV MUSKLESSFUNKTIONSFOERMAOGA OCH MAET- OCH REHABILITERINGSFOERFARANDE FOER MAETNING AV MUSKLERS FUNKTIONSFOERMAOGA OCH REHABILITERING AV DESSA |
US5469750A (en) * | 1991-03-05 | 1995-11-28 | Aradigm Corporation | Method and apparatus for sensing flow in two directions and automatic calibration thereof |
US6101478A (en) | 1997-04-30 | 2000-08-08 | Health Hero Network | Multi-user remote health monitoring system |
US5307263A (en) | 1992-11-17 | 1994-04-26 | Raya Systems, Inc. | Modular microprocessor-based health monitoring system |
US5956501A (en) | 1997-01-10 | 1999-09-21 | Health Hero Network, Inc. | Disease simulation system and method |
US5467656A (en) * | 1993-10-20 | 1995-11-21 | Liberty Mutual Insurance Co. | Measurement system for hand tools |
US5531697A (en) * | 1994-04-15 | 1996-07-02 | Sims Deltec, Inc. | Systems and methods for cassette identification for drug pumps |
US5536249A (en) * | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
US6018289A (en) | 1995-06-15 | 2000-01-25 | Sekura; Ronald D. | Prescription compliance device and method of using device |
US5890128A (en) | 1996-03-04 | 1999-03-30 | Diaz; H. Benjamin | Personalized hand held calorie computer (ECC) |
US5951492A (en) * | 1996-05-17 | 1999-09-14 | Mercury Diagnostics, Inc. | Methods and apparatus for sampling and analyzing body fluid |
US6159147A (en) * | 1997-02-28 | 2000-12-12 | Qrs Diagnostics, Llc | Personal computer card for collection of real-time biological data |
US5876351A (en) * | 1997-04-10 | 1999-03-02 | Mitchell Rohde | Portable modular diagnostic medical device |
US5857967A (en) | 1997-07-09 | 1999-01-12 | Hewlett-Packard Company | Universally accessible healthcare devices with on the fly generation of HTML files |
US6066243A (en) | 1997-07-22 | 2000-05-23 | Diametrics Medical, Inc. | Portable immediate response medical analyzer having multiple testing modules |
FI107080B (en) * | 1997-10-27 | 2001-05-31 | Nokia Mobile Phones Ltd | measuring device |
US6080106A (en) | 1997-10-28 | 2000-06-27 | Alere Incorporated | Patient interface system with a scale |
US5971941A (en) * | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
US6085576A (en) | 1998-03-20 | 2000-07-11 | Cyrano Sciences, Inc. | Handheld sensing apparatus |
US6558320B1 (en) * | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
ATE408372T1 (en) * | 1999-01-04 | 2008-10-15 | Terumo Corp | LANDZET ARRANGEMENT FOR COLLECTION AND DETECTION OF BODY FLUID |
US20020016923A1 (en) * | 2000-07-03 | 2002-02-07 | Knaus William A. | Broadband computer-based networked systems for control and management of medical records |
US20020177763A1 (en) * | 2001-05-22 | 2002-11-28 | Burns David W. | Integrated lancets and methods |
-
2001
- 2001-10-16 US US09/981,483 patent/US6966880B2/en not_active Expired - Lifetime
-
2004
- 2004-07-16 US US10/892,874 patent/US7575558B2/en not_active Expired - Lifetime
-
2009
- 2009-01-26 US US12/359,891 patent/US20090192410A1/en not_active Abandoned
-
2014
- 2014-08-11 US US14/456,520 patent/US20140350469A1/en not_active Abandoned
Patent Citations (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2880876A (en) * | 1954-10-02 | 1959-04-07 | Melotte Ecremeuses | Apparatus for separating a liquid from an overlying layer of foam |
US3063451A (en) * | 1959-09-28 | 1962-11-13 | Arthur J Kowalk | Self-venting type needle |
US3090384A (en) * | 1960-04-15 | 1963-05-21 | Mfg Process Lab Inc | Needle |
US3424154A (en) * | 1965-11-08 | 1969-01-28 | Charles W Kinsley | Injection system |
US3607097A (en) * | 1967-08-09 | 1971-09-21 | Philips Corp | Analyzer for liquid samples |
US4525164A (en) * | 1981-04-24 | 1985-06-25 | Biotek, Inc. | Wearable medication infusion system with arcuated reservoir |
US4661768A (en) * | 1983-09-14 | 1987-04-28 | Johnson Service Company | Capacitance transducing method and apparatus |
US4586926A (en) * | 1984-03-05 | 1986-05-06 | Cook, Incorporated | Percutaneous entry needle |
US5279294A (en) * | 1985-04-08 | 1994-01-18 | Cascade Medical, Inc. | Medical diagnostic system |
US4627445A (en) * | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
US4787398A (en) * | 1985-04-08 | 1988-11-29 | Garid, Inc. | Glucose medical monitoring system |
US4695273A (en) * | 1986-04-08 | 1987-09-22 | I-Flow Corporation | Multiple needle holder and subcutaneous multiple channel infusion port |
US4757022A (en) * | 1986-04-15 | 1988-07-12 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
US5029583A (en) * | 1986-07-22 | 1991-07-09 | Personal Diagnostics, Inc. | Optical analyzer |
US5064411A (en) * | 1988-11-04 | 1991-11-12 | Gordon Iii Kilbourn | Protective medical device |
US5208163A (en) * | 1990-08-06 | 1993-05-04 | Miles Inc. | Self-metering fluid analysis device |
US5104382A (en) * | 1991-01-15 | 1992-04-14 | Ethicon, Inc. | Trocar |
US5163442A (en) * | 1991-07-30 | 1992-11-17 | Harry Ono | Finger tip blood collector |
US5217476A (en) * | 1991-10-01 | 1993-06-08 | Medical Sterile Products, Inc. | Surgical knife blade and method of performing cataract surgery utilizing a surgical knife blade |
US5917429A (en) * | 1992-09-14 | 1999-06-29 | Aprex Corporation | Contactless communication system |
US6172743B1 (en) * | 1992-10-07 | 2001-01-09 | Chemtrix, Inc. | Technique for measuring a blood analyte by non-invasive spectrometry in living tissue |
US6144976A (en) * | 1993-02-26 | 2000-11-07 | Norand Corporation | Hand-held data collection computer terminal having power management architecture including switchable multi-purpose input display screen |
US5700695A (en) * | 1994-06-30 | 1997-12-23 | Zia Yassinzadeh | Sample collection and manipulation method |
US5858195A (en) * | 1994-08-01 | 1999-01-12 | Lockheed Martin Energy Research Corporation | Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis |
WO1996012546A1 (en) * | 1994-10-19 | 1996-05-02 | Hewlett-Packard Company | Miniaturized planar columns for use in a liquid phase separation apparatus |
US6729546B2 (en) * | 1994-10-26 | 2004-05-04 | Symbol Technologies, Inc. | System for reading two-dimensional images using ambient and/or projected light |
USRE38803E1 (en) * | 1995-01-25 | 2005-09-27 | Robert E. Rodgers, Jr. | Stationary exercise apparatus having a preferred foot platform path |
US5873856A (en) * | 1995-06-22 | 1999-02-23 | Pharmacia Ab | Limited depth penetration needle housing |
US5772586A (en) * | 1996-02-12 | 1998-06-30 | Nokia Mobile Phones, Ltd. | Method for monitoring the health of a patient |
US6537264B1 (en) * | 1996-06-18 | 2003-03-25 | Alza Corp | Device and method for enhancing transdermal flux of agents being sampled |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US6447119B1 (en) * | 1996-08-12 | 2002-09-10 | Visionrx, Inc. | Apparatus for visualizing the eye's tear film |
US5892569A (en) * | 1996-11-22 | 1999-04-06 | Jozef F. Van de Velde | Scanning laser ophthalmoscope optimized for retinal microphotocoagulation |
US6093156A (en) * | 1996-12-06 | 2000-07-25 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
US5938635A (en) * | 1996-12-30 | 1999-08-17 | Kuhle; William G. | Biopsy needle with flared tip |
US5827179A (en) * | 1997-02-28 | 1998-10-27 | Qrs Diagnostic, Llc | Personal computer card for collection for real-time biological data |
US5950632A (en) * | 1997-03-03 | 1999-09-14 | Motorola, Inc. | Medical communication apparatus, system, and method |
US5961451A (en) * | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
US6224617B1 (en) * | 1997-10-17 | 2001-05-01 | Angiotrax, Inc. | Methods and apparatus for defibrillating a heart refractory to electrical stimuli |
US6102872A (en) * | 1997-11-03 | 2000-08-15 | Pacific Biometrics, Inc. | Glucose detector and method |
US6071294A (en) * | 1997-12-04 | 2000-06-06 | Agilent Technologies, Inc. | Lancet cartridge for sampling blood |
US5871494A (en) * | 1997-12-04 | 1999-02-16 | Hewlett-Packard Company | Reproducible lancing for sampling blood |
US6579690B1 (en) * | 1997-12-05 | 2003-06-17 | Therasense, Inc. | Blood analyte monitoring through subcutaneous measurement |
US6309370B1 (en) * | 1998-02-05 | 2001-10-30 | Biosense, Inc. | Intracardiac drug delivery |
US6183442B1 (en) * | 1998-03-02 | 2001-02-06 | Board Of Regents Of The University Of Texas System | Tissue penetrating device and methods for using same |
US5940153A (en) * | 1998-04-03 | 1999-08-17 | Motorola, Inc. | Display assembly having LCD and seal captured between interlocking lens cover and lightpipe |
US6200289B1 (en) * | 1998-04-10 | 2001-03-13 | Milestone Scientific, Inc. | Pressure/force computer controlled drug delivery system and the like |
US20010037072A1 (en) * | 1998-08-24 | 2001-11-01 | Virtanen Jorma A. | Cassette and applicator for biological and chemical sample collection |
US6117115A (en) * | 1998-10-12 | 2000-09-12 | B. Braun Medical, Inc. | Medical tubing slide clamp device for determining proper tubing size and functional characteristics |
US6149787A (en) * | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
US6419661B1 (en) * | 1999-03-05 | 2002-07-16 | Roche Diagnostics Gmbh | Device for withdrawing blood for diagnostic applications |
US6375626B1 (en) * | 1999-03-12 | 2002-04-23 | Integ, Inc. | Collection well for body fluid tester |
DE19928412A1 (en) * | 1999-06-22 | 2001-01-11 | Agilent Technologies Inc | Supply system to prepare a microchip with a microfluid structure has a sealed supply for the material which is penetrated on contact with the microchip and further supplies to give the material a movement potential on the microchip |
US20030092982A1 (en) * | 1999-08-12 | 2003-05-15 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6358196B1 (en) * | 1999-12-29 | 2002-03-19 | Reiza Rayman | Magnetic retraction system for laparoscopic surgery and method of use thereof |
US20010018353A1 (en) * | 2000-02-29 | 2001-08-30 | Matsushita Electric Industrial Co., Ltd. | Portable telephone with bookmark sort function |
US20020058902A1 (en) * | 2000-05-01 | 2002-05-16 | Nikiforos Kollias | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
US6599281B1 (en) * | 2000-05-03 | 2003-07-29 | Aspect Medical Systems, Inc. | System and method for adaptive drug delivery |
US20020020646A1 (en) * | 2000-06-09 | 2002-02-21 | Groth Lars Morch | Needle magazine |
US20090076415A1 (en) * | 2000-06-09 | 2009-03-19 | Piet Moerman | Cap for a Lancing Device |
US20020111634A1 (en) * | 2000-08-30 | 2002-08-15 | Johns Hopkins University | Controllable motorized device for percutaneous needle placement in soft tissue target and methods and systems related thereto |
US6808499B1 (en) * | 2000-09-29 | 2004-10-26 | University Of Vermont | Therapeutic and diagnostic needling device and method |
US20020109600A1 (en) * | 2000-10-26 | 2002-08-15 | Mault James R. | Body supported activity and condition monitor |
US20040068283A1 (en) * | 2001-01-12 | 2004-04-08 | Masahiro Fukuzawa | Puncturing device |
US20020156355A1 (en) * | 2001-02-15 | 2002-10-24 | Gough David A. | Membrane and electrode structure for implantable sensor |
US7976778B2 (en) * | 2001-04-02 | 2011-07-12 | Abbott Diabetes Care Inc. | Blood glucose tracking apparatus |
US6591124B2 (en) * | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US20090118752A1 (en) * | 2001-06-08 | 2009-05-07 | Edward Perez | Devices and methods for expression of bodily fluids from an incision |
US20120149999A1 (en) * | 2001-06-12 | 2012-06-14 | Dominique Freeman | Tissue penetration device |
US8206319B2 (en) * | 2001-06-12 | 2012-06-26 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7749174B2 (en) * | 2001-06-12 | 2010-07-06 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge |
US20030069509A1 (en) * | 2001-10-10 | 2003-04-10 | David Matzinger | Devices for physiological fluid sampling and methods of using the same |
US6966880B2 (en) * | 2001-10-16 | 2005-11-22 | Agilent Technologies, Inc. | Universal diagnostic platform |
US7645263B2 (en) * | 2001-10-26 | 2010-01-12 | Massachusetts Institute Of Technology | Impedance sensor |
US20110077553A1 (en) * | 2001-11-27 | 2011-03-31 | Shl Telemedicine International Ltd. | Device for sampling blood droplets under vacuum conditions |
US20030136189A1 (en) * | 2002-01-22 | 2003-07-24 | Brian Lauman | Capacitance fluid volume measurement |
US7901365B2 (en) * | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20070142748A1 (en) * | 2002-04-19 | 2007-06-21 | Ajay Deshmukh | Tissue penetration device |
US8491500B2 (en) * | 2002-04-19 | 2013-07-23 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US20110077478A1 (en) * | 2002-04-19 | 2011-03-31 | Dominique Freeman | Body fluid sampling module with a continuous compression tissue interface surface |
US7713214B2 (en) * | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
US20110098541A1 (en) * | 2002-04-19 | 2011-04-28 | Dominique Freeman | Method and apparatus for penetrating tissue |
US20120232425A1 (en) * | 2002-04-19 | 2012-09-13 | Freeman Dominique M | Method and apparatus for penetrating tissue |
US20090112247A1 (en) * | 2002-04-19 | 2009-04-30 | Dominique Freeman | Method and apparatus for penetrating tissue |
US20120184876A1 (en) * | 2002-04-19 | 2012-07-19 | Freeman Dominique M | Method and apparatus for penetrating tissue |
US8197421B2 (en) * | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20030211619A1 (en) * | 2002-05-09 | 2003-11-13 | Lorin Olson | Continuous strip of fluid sampling and testing devices and methods of making, packaging and using the same |
US20040065669A1 (en) * | 2002-06-25 | 2004-04-08 | Giraud Jean Pierre | Moisture-proof resealable, non-cylindrical container for consumer packages |
US20040068093A1 (en) * | 2002-07-01 | 2004-04-08 | The Procter & Gamble Company | Polymerized hydrogel comprising low amounts of residual monomers and by-products |
US20060229652A1 (en) * | 2003-07-31 | 2006-10-12 | Matsushita Electric Industrial Co., Ltd | Puncturing instrument, puncturing needle cartridge, puncturing instrument set, and puncturing needle discardment instrument |
US20060222566A1 (en) * | 2003-08-01 | 2006-10-05 | Brauker James H | Transcutaneous analyte sensor |
US20080255598A1 (en) * | 2003-08-20 | 2008-10-16 | Facet Technologies, Llc | Lancing Device With Replaceable Multi-Lancet Carousel |
US8282576B2 (en) * | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US20050187442A1 (en) * | 2004-02-24 | 2005-08-25 | Ok-Kyung Cho | Blood sugar level measuring apparatus |
US20070118051A1 (en) * | 2004-04-10 | 2007-05-24 | Stephan Korner | Method and system for withdrawing body fluid |
US20060100542A9 (en) * | 2004-04-15 | 2006-05-11 | Daniel Wong | Integrated spot monitoring device with fluid sensor |
US7879058B2 (en) * | 2004-04-26 | 2011-02-01 | Asahi Polyslider Company, Limted | Lancet device for forming incision |
US20080042594A1 (en) * | 2004-06-30 | 2008-02-21 | Daniel Lopez | Power Supply for a Metal Vapour Lamp |
US20060234263A1 (en) * | 2005-03-10 | 2006-10-19 | Gen-Probe Incorporated | Method for reducing the presence of amplification inhibitors in a reaction receptacle |
US20070123803A1 (en) * | 2005-10-12 | 2007-05-31 | Masaki Fujiwara | Blood sensor, blood testing apparatus, and method for controlling blood testing apparatus |
US20090270765A1 (en) * | 2005-11-30 | 2009-10-29 | Abbott Diabetes Care Inc. | Integrated meter for analyzing biological samples |
US20090177117A1 (en) * | 2006-01-31 | 2009-07-09 | Matsushita Electric Industrial Co., Ltd. | Blood test method and blood test apparatus |
US8231548B2 (en) * | 2006-07-18 | 2012-07-31 | Roche Diagnostics Operations, Inc. | Portable measuring system having a moisture-proof assembly space |
US20080047764A1 (en) * | 2006-08-28 | 2008-02-28 | Cypress Semiconductor Corporation | Temperature compensation method for capacitive sensors |
US20100256525A1 (en) * | 2007-04-18 | 2010-10-07 | Hans List | Lancing and analysis device |
US20100274273A1 (en) * | 2007-06-19 | 2010-10-28 | Steven Schraga | Lancet device with depth adjustment and lancet removal system and method |
US8388639B2 (en) * | 2007-08-14 | 2013-03-05 | Owen Mumford Limited | Lancing devices |
US8251922B2 (en) * | 2007-10-08 | 2012-08-28 | Roche Diagnostics Operations, Inc. | Analysis system for automatic skin prick analysis |
US20090099477A1 (en) * | 2007-10-15 | 2009-04-16 | Joachim Hoenes | Lancet wheel |
US20090119760A1 (en) * | 2007-11-06 | 2009-05-07 | National Tsing Hua University | Method for reconfiguring security mechanism of a wireless network and the mobile node and network node thereof |
US20100113981A1 (en) * | 2008-05-09 | 2010-05-06 | Panasonic Corporation | Skin incision instrument and method for incising skin with the same |
US20110184448A1 (en) * | 2008-06-05 | 2011-07-28 | Bayer Healthcare Llc | Lancing device |
US20100094324A1 (en) * | 2008-10-14 | 2010-04-15 | Bionime Corporation | Lancing device |
US20100131440A1 (en) * | 2008-11-11 | 2010-05-27 | Nec Laboratories America Inc | Experience transfer for the configuration tuning of large scale computing systems |
US20110178429A1 (en) * | 2010-01-19 | 2011-07-21 | Jacobs Christopher A | Vacuum assisted lancing system and method for blood extraction with minimal pain |
US20130261500A1 (en) * | 2010-01-19 | 2013-10-03 | Christopher A. Jacobs | Vacuum assisted lancing system and method for blood extraction with minimal pain |
US20120271197A1 (en) * | 2010-06-02 | 2012-10-25 | Mark Castle | Methods and apparatus for lancet actuation |
Cited By (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8439872B2 (en) | 1998-03-30 | 2013-05-14 | Sanofi-Aventis Deutschland Gmbh | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8211037B2 (en) | 2001-06-12 | 2012-07-03 | Pelikan Technologies, Inc. | Tissue penetration device |
US8622930B2 (en) | 2001-06-12 | 2014-01-07 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7909775B2 (en) | 2001-06-12 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US9937298B2 (en) | 2001-06-12 | 2018-04-10 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8845550B2 (en) | 2001-06-12 | 2014-09-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8721671B2 (en) | 2001-06-12 | 2014-05-13 | Sanofi-Aventis Deutschland Gmbh | Electric lancet actuator |
US8016774B2 (en) | 2001-06-12 | 2011-09-13 | Pelikan Technologies, Inc. | Tissue penetration device |
US8641643B2 (en) | 2001-06-12 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Sampling module device and method |
US7981055B2 (en) | 2001-06-12 | 2011-07-19 | Pelikan Technologies, Inc. | Tissue penetration device |
US9802007B2 (en) | 2001-06-12 | 2017-10-31 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7988645B2 (en) | 2001-06-12 | 2011-08-02 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US8206317B2 (en) | 2001-06-12 | 2012-06-26 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9694144B2 (en) | 2001-06-12 | 2017-07-04 | Sanofi-Aventis Deutschland Gmbh | Sampling module device and method |
US8679033B2 (en) | 2001-06-12 | 2014-03-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8382683B2 (en) | 2001-06-12 | 2013-02-26 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8360991B2 (en) | 2001-06-12 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8123700B2 (en) | 2001-06-12 | 2012-02-28 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US8343075B2 (en) | 2001-06-12 | 2013-01-01 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8162853B2 (en) | 2001-06-12 | 2012-04-24 | Pelikan Technologies, Inc. | Tissue penetration device |
US8337421B2 (en) | 2001-06-12 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8282577B2 (en) | 2001-06-12 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US8216154B2 (en) | 2001-06-12 | 2012-07-10 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8206319B2 (en) | 2001-06-12 | 2012-06-26 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9560993B2 (en) | 2001-11-21 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9339612B2 (en) | 2002-04-19 | 2016-05-17 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8235915B2 (en) | 2002-04-19 | 2012-08-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US9907502B2 (en) | 2002-04-19 | 2018-03-06 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US8197423B2 (en) | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9839386B2 (en) | 2002-04-19 | 2017-12-12 | Sanofi-Aventis Deustschland Gmbh | Body fluid sampling device with capacitive sensor |
US7901365B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8333710B2 (en) | 2002-04-19 | 2012-12-18 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8197421B2 (en) | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8337420B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8157748B2 (en) | 2002-04-19 | 2012-04-17 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8079960B2 (en) | 2002-04-19 | 2011-12-20 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8366637B2 (en) | 2002-04-19 | 2013-02-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US8382682B2 (en) | 2002-04-19 | 2013-02-26 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8062231B2 (en) | 2002-04-19 | 2011-11-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8388551B2 (en) | 2002-04-19 | 2013-03-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for multi-use body fluid sampling device with sterility barrier release |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9724021B2 (en) | 2002-04-19 | 2017-08-08 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8403864B2 (en) | 2002-04-19 | 2013-03-26 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8414503B2 (en) | 2002-04-19 | 2013-04-09 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US8430828B2 (en) | 2002-04-19 | 2013-04-30 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US8435190B2 (en) | 2002-04-19 | 2013-05-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8007446B2 (en) | 2002-04-19 | 2011-08-30 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8491500B2 (en) | 2002-04-19 | 2013-07-23 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US8496601B2 (en) | 2002-04-19 | 2013-07-30 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US8556829B2 (en) | 2002-04-19 | 2013-10-15 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8562545B2 (en) | 2002-04-19 | 2013-10-22 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8574168B2 (en) | 2002-04-19 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a multi-use body fluid sampling device with analyte sensing |
US7909777B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7988644B2 (en) | 2002-04-19 | 2011-08-02 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US8636673B2 (en) | 2002-04-19 | 2014-01-28 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US8202231B2 (en) | 2002-04-19 | 2012-06-19 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9498160B2 (en) | 2002-04-19 | 2016-11-22 | Sanofi-Aventis Deutschland Gmbh | Method for penetrating tissue |
US7959582B2 (en) | 2002-04-19 | 2011-06-14 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8690796B2 (en) | 2002-04-19 | 2014-04-08 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7909774B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7938787B2 (en) | 2002-04-19 | 2011-05-10 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US8808201B2 (en) | 2002-04-19 | 2014-08-19 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for penetrating tissue |
US7875047B2 (en) | 2002-04-19 | 2011-01-25 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US8845549B2 (en) | 2002-04-19 | 2014-09-30 | Sanofi-Aventis Deutschland Gmbh | Method for penetrating tissue |
US7914465B2 (en) | 2002-04-19 | 2011-03-29 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8905945B2 (en) | 2002-04-19 | 2014-12-09 | Dominique M. Freeman | Method and apparatus for penetrating tissue |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9186468B2 (en) | 2002-04-19 | 2015-11-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9089294B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9089678B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9072842B2 (en) | 2002-04-19 | 2015-07-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9034639B2 (en) | 2002-12-30 | 2015-05-19 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US8262614B2 (en) | 2003-05-30 | 2012-09-11 | Pelikan Technologies, Inc. | Method and apparatus for fluid injection |
US8251921B2 (en) | 2003-06-06 | 2012-08-28 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US9144401B2 (en) | 2003-06-11 | 2015-09-29 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US10034628B2 (en) | 2003-06-11 | 2018-07-31 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US8945910B2 (en) | 2003-09-29 | 2015-02-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US8296918B2 (en) | 2003-12-31 | 2012-10-30 | Sanofi-Aventis Deutschland Gmbh | Method of manufacturing a fluid sampling device with improved analyte detecting member configuration |
US9561000B2 (en) | 2003-12-31 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US9261476B2 (en) | 2004-05-20 | 2016-02-16 | Sanofi Sa | Printable hydrogel for biosensors |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US9874559B2 (en) | 2010-11-24 | 2018-01-23 | Inanovate, Inc. | Capacitive pumping and flow control |
US10060919B2 (en) | 2010-11-24 | 2018-08-28 | Inanovate, Inc. | Longitudinal assay |
US8975087B2 (en) | 2010-11-24 | 2015-03-10 | Inanovate, Inc. | Longitudinal assay |
US20130066562A1 (en) * | 2011-09-09 | 2013-03-14 | Alverix, Inc. | In-vitro diagnostic device using external information in conjunction with test results |
US10706966B2 (en) | 2011-09-09 | 2020-07-07 | Alverix, Inc. | Distributed network of in-vitro diagnostic devices |
US9715579B2 (en) * | 2011-09-09 | 2017-07-25 | Alverix, Inc. | Distributed network of in-vitro diagnostic devices |
US20170160258A1 (en) * | 2011-09-09 | 2017-06-08 | Alverix, Inc. | In-vitro diagnostic device using external information in conjunction with test results |
US9524372B2 (en) * | 2011-09-09 | 2016-12-20 | Alverix, Inc. | In-vitro diagnostic device using external information in conjunction with test results |
US20180128805A1 (en) * | 2011-09-09 | 2018-05-10 | Alverix, Inc. | In-vitro diagnostic device using external information in conjunction with test results |
US11152116B2 (en) | 2011-09-09 | 2021-10-19 | Alverix, Inc. | Distributed network of in-vitro diagnostic devices |
US10976298B2 (en) * | 2011-09-09 | 2021-04-13 | Alverix, Inc. | Lateral flow assay testing device using external information in conjunction with test results |
US10180417B2 (en) * | 2011-09-09 | 2019-01-15 | Alverix, Inc. | In-vitro diagnostic device using external information in conjunction with test results |
US10458972B2 (en) * | 2011-09-09 | 2019-10-29 | Alverix, Inc. | In-vitro diagnostic device using external information in conjunction with test results |
US20130066563A1 (en) * | 2011-09-09 | 2013-03-14 | Alverix, Inc. | Distributed network of in-vitro diagnostic devices |
WO2014150869A1 (en) * | 2013-03-15 | 2014-09-25 | Inanovate, Inc. | Cartridge device for processing time-resolved assays |
WO2014150853A1 (en) * | 2013-03-15 | 2014-09-25 | Inanovate, Inc. | Analyte measurement using longitudinal assay |
US11397181B2 (en) | 2016-06-22 | 2022-07-26 | Becton, Dickinson And Company | Modular assay reader device |
US11802869B2 (en) | 2016-06-22 | 2023-10-31 | Becton, Dickinson And Company | Modular assay reader device |
Also Published As
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US7575558B2 (en) | 2009-08-18 |
US20040260204A1 (en) | 2004-12-23 |
US6966880B2 (en) | 2005-11-22 |
US20140350469A1 (en) | 2014-11-27 |
US20030073931A1 (en) | 2003-04-17 |
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