US20110034795A9 - Device, system and method for in-vivo imaging of a body lumen - Google Patents
Device, system and method for in-vivo imaging of a body lumen Download PDFInfo
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- US20110034795A9 US20110034795A9 US11/284,915 US28491505A US2011034795A9 US 20110034795 A9 US20110034795 A9 US 20110034795A9 US 28491505 A US28491505 A US 28491505A US 2011034795 A9 US2011034795 A9 US 2011034795A9
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
- A61B1/0676—Endoscope light sources at distal tip of an endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
- A61B1/0684—Endoscope light sources using light emitting diodes [LED]
Definitions
- the present invention relates to the field of in-vivo diagnostics. More specifically, the present invention relates to a device, system and method for imaging a body lumen.
- Known devices may be helpful in providing in-vivo imaging.
- Autonomous in-vivo imaging devices such as swallowable or ingestible capsules or other devices may move through a body lumen, imaging as they move along. Some of these devices use a wireless connection to transmit image data. Some in-vivo imaging devices have a limited field-of-view. Some desirable portions of an in-vivo lumen may not be imaged with such fields of view.
- a device, system and method for imaging a body lumen there is thus provided, according to embodiments of the invention, a device, system and method for imaging a body lumen. According to an embodiment of the invention there is provided a device, system and method for imaging typically voluminous, usually liquid filled body lumens, for example, the stomach.
- a typically floatable imaging device or a device having other suitable weight or mass distribution or specific gravity, is moved through a body lumen, such as the large intestine or stomach, by using the passage of a volume of liquid within and/or through the body lumen.
- the floatable in-vivo imaging device may have a specific gravity of about 1 or less, or a volume to weight ratio that enables it essentially to float, for example, in a body lumen liquid, for example the liquid typically found in the human stomach, or for example liquid that may be administered to a patient to fill a lumen such as the stomach.
- the floatable imaging device may be inserted in-vivo.
- a typically autonomous floatable device may be ingested and moved through the GI tract, typically by peristalsis.
- the device When reaching a relatively voluminous liquid filled lumen, such as the stomach, the device, which may float in the volume of liquid, may be moved through the lumen in accordance with the movement of the volume of liquid.
- Other embodiments may include other suitable devices and methods.
- a method for imaging body lumens such as the large intestine or the stomach.
- the method comprises the step of inserting a floatable in-vivo device into a patient lumen, for example by swallowing the imaging device, preferably after which a patient ingests a volume of liquid, for example water or juice.
- the method is used for imaging the stomach and may comprise the step of ingesting a composition to retrain liquids in the body lumen.
- FIG. 1A is a schematic diagram of an embodiment of an in-vivo imaging device and an external receiver and transmitter system in accordance with an embodiment of the invention
- FIG. 1B is a schematic diagram of an embodiment of an in-vivo imaging device according to another embodiment of the present invention.
- FIG. 2 is a schematic two dimensional presentation of an optical system according to an embodiment of the present invention.
- FIG. 3 is a schematic cross-sectional representation of volumes of space included in an in-vivo imaging device in accordance with an embodiment of the invention
- FIGS. 4A and 4B are schematic illustrations of an imaging devices being moved through a body lumen in accordance with an embodiment of the invention
- FIG. 5 is a box diagram depicting a method for in-vivo imaging according to an embodiment of the invention.
- FIG. 6 is a schematic flow-chart of a method of manufacturing a floatable in-vivo imaging device in accordance with some embodiments of the invention.
- FIG. 1A schematically illustrates an in-vivo imaging device and system according to an embodiment of the present invention.
- An embodiment of the present invention may provide a floatable in-vivo imaging device 40 that can be carried by liquid 39 .
- the imaging device 40 may be useful in imaging lumens containing or capable of containing a bulk of liquid 39 .
- device 40 may include two optical heads, for example two transparent empty-spaced elongated optical domes 30 and 30 ′ behind which are situated illumination sources 34 , such as one or more LEDs (Light Emitting Diode), and/or OLEDs (Organic LED) or other illumination sources, two optical systems such as lens holders 32 and 32 ′, two imagers 36 and 36 ′ (such as for example a CMOS, a CCD, etc.) a transmitter 35 (such as an ASIC) and/or a receiver and a processor 37 .
- illumination sources 34 such as one or more LEDs (Light Emitting Diode), and/or OLEDs (Organic LED) or other illumination sources
- two optical systems such as lens holders 32 and 32 ′, two imagers 36 and 36 ′ (such as for example a CMOS, a CCD, etc.)
- a transmitter 35 such as an ASIC
- a receiver and a processor 37 such as an ASIC
- the device 40 may further include power source(s) 33 , which may provide power to the entirety of electrical elements of the device, an antenna 31 for transmitting and receiving, for example video signals from the imagers 36 and 36 ′. While two domes and optical systems are shown, other numbers, such as one or more than two (if device 40 is spherical shaped, for example), may be used
- device 40 is capable of simultaneously obtaining images of the body lumen, for example, the stomach, from two ends of the device.
- device 40 may be a cylindrical capsule having a front end and a rear end, which is capable of passing the entire GI tract.
- the elongated empty-spaced domes 30 and 30 ′ may be for example hemispherical shaped optical domes having optical properties that are taken into account when designing the lens holders 32 and 32 ′ such as for example setting the spacing between the lenses in the lens holders 32 and 32 ′.
- device 40 may include suitable optical systems for viewing through a liquid as well as for viewing through a substantially non liquid medium.
- a lens holder such as lens holder 32 suitable for viewing through air (e.g. compatible with the refractive index of the air) may be placed behind transparent elongated optical dome 30 (which may be also suitable for viewing through air), while behind the transparent elongated optical dome 30 ′ may be placed a lens holder, such as lens holder 32 ′ suitable for viewing through liquid (e.g. compatible with the refractive index of the liquid)
- the in vivo imaging device has a specific gravity (SG) of about 1.0 or a volume to weight ratio that enables it essentially to float such that the imagers 36 and 36 ′ may be oriented in a plane parallel to or substantially parallel to a short axis “B” of device 40 , and/or may be perpendicular to or substantially perpendicular to long axis A.
- SG specific gravity
- Deviations from “horizontal” and “vertical” positions, such as angling, from long axis A or short axis B may be used.
- vertical and horizontal are relative terms, and may be interchangeable based on perspectives of the viewer, or based on specific embodiments.
- outside a patient's body may be, for example, an image receiver 90 (including, for example, an antenna or an antenna array), a storage unit 91 , a data processor 92 , and a monitor 93 .
- device 40 may communicate with an external receiving and display system (e.g, through receiver 90 ) to provide display of data, control, or other functions
- an external receiving and display system e.g, through receiver 90
- power may be provided to device 40 using an internal battery, an internal power source, or a wireless system to receive power.
- Other embodiments may have other configurations and capabilities.
- components may be distributed over multiple sites or units, and control information may be received from an external source.
- device 40 typically may be or may include an autonomous swallowable capsule, but device 40 may have other shapes and need not be swallowable or autonomous.
- Embodiments of device 40 are typically autonomous, and are typically self-contained.
- device 40 may be a capsule or other unit where all the components are substantially contained within a container or shell, and where device 40 does not require any wires or cables to, for example, receive power or transmit information.
- all of the components may be sealed within the device body (the body or shell may include more than one piece); for example, the imagers 36 and 36 ′, the illumination sources 34 , the power source(s), and the transmitter, may all be sealed within the device body
- the system and method of the present invention may be used with or in an imaging system such as that described in U.S. patent application, Ser. No. 09/800,470, entitled A DEVICE AND SYSTEM FOR IN-VIVO IMAGING, filed on Mar. 8, 2001.
- a further example of an imaging system with which the system and method of the present invention may be used is described in U.S. Pat. No. 5,604,531 to Iddan et al., entitled IN-VIVO VIDEO CAMARA SYSTEM, filed on Jan. 17, 1995. Both these publications are assigned to the common assignee of the present application and are hereby incorporated by reference.
- the system of the present invention may be utilized in any suitable imaging device providing images of a body lumen or cavity
- a circuit board according to an embodiment of the invention may be utilized in probes used for in-vivo imaging, such as endoscopes.
- device 80 may include an optical head, for example a transparent empty-spaced elongated optical dome 94 behind which are situated illumination sources 84 , such as one or more LEDs (Light Emitting Diode), and/or OLEDs (Organic LED) or other illumination sources, an optical system such as a lens holder 82 and an imager 86 (such as for example a CMOS, a CCD, etc.) a transmitter 85 (such as an RF transmitter) and/or a receiver and a processor 87 .
- the device 80 may further include power source(s) 83 , which may provide power to the entirety of electrical elements of the device, an antenna 81 for transmitting and/or receiving. For example, the antenna may be used to transmit video signals from the imager 86 .
- device 80 may include suitable optical systems for viewing through liquid.
- the lens holder 82 may be suitable for viewing through liquid (e.g. compatible with the refractive index of the liquid).
- device 80 may be designed such the transparent empty-spaced elongated optical domes 94 will always be submerged in a liquid 89 , such as, for example, a typical human stomach fluid, or fluid of other body parts.
- a liquid 89 such as, for example, a typical human stomach fluid, or fluid of other body parts.
- the transparent empty-spaced elongated optical domes 94 bearing the optical system compatible for under water imaging will be submerged
- FIG. 2 is a schematic two dimensional presentation of an exemplary lens construction, according to an embodiment of the present invention.
- the lens construction referenced as 10 may be provided in the lens holder 32 ′ included in, for example, device 40 of FIG. 1 , but may be included in other suitable devices, such as an endoscope, trocar, or other in-vivo imaging device.
- the lens holder may include three lens elements L 1 , L 2 , and L 3 suitable for viewing through liquid (e.g.
- the first lens L 1 may be, for example a focusing lens such as a planoconcave lens having a flat lens surface on the side of the subject and a concave lens surface on the image-forming side.
- the second lens L 2 which may be used for correcting aberrations may be, for example planoconvex lens L 2 and may be located next to the first lens L 1 .
- the third lens L 3 may be a field lens such as a convex lens.
- Interposed between the first lens L 1 and the second lens L 2 may be for example an aperture, such as an aperture stop 16 , which determines the amount of light which reaches an imager and/or an imager area such as imagers 36 and 36 ′.
- an optical design of a lens holder such as lens holder 32 , suitable for viewing through air, may be provided, by replacing one of the lens elements L 1 , L 2 , and L 3 of lens holder 32 ′, or by changing the surface shape of one of the lens's.
- the lens construction of lens holder 32 may be formed by replacing lens L 3 or by changing the surface L 3 ′ of lens L 3 .
- changing the refractive index and the optical design of the lens construction 10 e.g. from a lens construction suitable for viewing through liquid to a lens construction suitable for viewing through air
- the refractive index and/or the optical design of a lens construction may be changed by using, for example an adaptive optical lens structure such as a low control voltage liquid crystals (LCs).
- an adaptive optical lens structure such as a low control voltage liquid crystals (LCs).
- the length of the adaptive optical lens may be tuned from one focal length to another focal length and may provide a sharp, clean image.
- the elongated typically empty-spaced dome(s) 30 and 30 ′ may include one or more volumes of space empty of components, for example spaces 1 .
- the volume(s) of spaces 1 may be each greater than twice the volume of a central volume of space 11 which may include components that may be located at or near the center of the imaging device 40 .
- the components comprising the central volume of space 11 may typically be the lens holders 32 and 32 ′, imagers 36 and 36 ′ and components described hereinafter.
- device 40 may be designed such that one section of device 40 , for example section 50 which may include the optical system which is suitable for viewing through a liquid 39 , e.g optical dome 30 ′ lens holder 32 ′ and imager 36 ′, will be submerged in a liquid 39 , such as, for example, a typical human stomach fluid, or fluid of other body parts, while the other section of device 40 , for example section 50 ′ which may include optical dome 30 ′ lens holder 32 ′ and imager 36 ′, will be exposed, bearing an optical system suitable for viewing through air which will be kept floating at all time.
- a liquid 39 such as, for example, a typical human stomach fluid, or fluid of other body parts
- the center of gravity of device 40 is adjusted to ensure that one side of device 40 , e g. section 50 will remain afloat while the other side, e.g. section 50 ′ will be submerged when moving through the liquid 39 .
- the center of gravity may be set in the section, or in proximity to the section of the device 40 that we wish to keep submerged during the device 40 movement.
- the center of gravity may be set through the positioning of certain components of the device 40 in desired areas, or designing the device 40 in a way that ensures that the device 40 specific weight is compatible to the shape of the outer envelope, and thus both the head and tail of the device 40 such as the dome(s) 30 and 30 ′ are at an angle perpendicular to the fluid.
- the components placed in the central volume of space 11 may be arranged in such a way which will result in a center of gravity located in proximity to the elongated optical dome 30 ′, which was adapted and optimized for viewing and imaging through liquid.
- the empty volume(s) I and/or the central volume of space II may render the device floatable in a liquid filled lumen.
- the floatable in-vivo imaging device 40 may include one or more buoyant bod(ies) or other weight, specific gravity, ballast or mass controlling system.
- the buoyant body which may be attached to the floatable in-vivo imaging device 40 or which may optionally house the floatable in-vivo imaging device and/or one or more elements of the floatable in-vivo imaging device 40 , may keep the in-vivo imaging device 40 essentially floating in a liquid filled body lumen for example, in a typical human stomach fluid.
- Embodiments including a floatable imaging device are described, for example, in U.S. application Ser. No. 10/150,492 entitled “Floatable in-vivo Sensing Device and Method for Use” published on Jan. 23, 2003 which is assigned to the assignee of the present invention and which is hereby incorporated by reference.
- Other suitable specific gravity configurations or floatation systems may be used.
- one or more ballast(s) 38 may be included in the device 40 for allowing one portion of the device 40 such as section 50 , which may include lens holder 32 and imager 36 , to be usually oriented in a fixed direction, for example, in a counter gravity direction.
- the internal components of a device may be packaged so as to shift the center of gravitand create ballast in one portion of the device, for example, batteries and electronic components may be packaged at one end of an encapsulated system so as to create ballast at that end.
- additional equipment may not be needed to, for example, alter the buoyancy or specific gravity of the device or to alter the weight distribution of the device, as such configurations may be done with components already part of the device, such as a gas such as air, CO 2 , N 2 , etc occurring within the device, etc
- the device 40 center of gravity may enable the elongated typically empty-spaced dome, such as dome 30 and an optical system, such as lens holder 32 compatible with the refractive index of the air, to float high above the fluid surface so that it is positioned above surface foam and bubbles which can interfere with image quality and field of view.
- an optical system such as lens holder 32 compatible with the refractive index of the air
- FIGS. 4A and 4B schematically illustrate a sensing device, for example the floatable in-vivo imaging device 40 , being moved through a body lumen in accordance with an embodiment of the invention
- the floatable in-vivo imaging device 40 may be inserted into a patient's stomach 20 , for example, by swallowing.
- the stomach 20 is filled with a volume of liquid 22 , which may be, for example, water, tea, juice, hyperosmolar liquid or any other suitable liquid, which is typically ingested by the patient at about the time of arrival of the device 40 to the stomach 20 .
- the floatable imaging device 40 will be kept afloat in the liquid 22 , enabling the device a multi-directional viewing ability.
- the device 40 may include more than one imaging system to enable multi directional viewing and/or imaging.
- two imagers for example imagers 36 and 36 ′ situated on opposing sides or ends of the device 40 , may enable multi-directional viewing and/or imaging, for example imaging above and below the liquid level 27 .
- multi-directional viewing ability may include illumination field and/or a field of view of the area above the liquid level 27 , for example area 29 .
- multi-directional viewing ability may include field of view in the opposite direction, e g. illumination field and/or a field of view of the area below the liquid level 27 , for example area 23 , that may be for example filled with a volume of liquid 22
- the device may be floatable in the sense that its specific gravity is approximately the same or less than a liquid inserted into or known to be in a body lumen.
- Natural action of the GI tract, including the stomach, typically causes liquids to be emptied from lumens, such as the stomach, within a certain time frame.
- liquid 22 may be naturally emptied from the stomach 20 over a period of 20-30 minutes, while moving in the direction shown, for example, by arrows 110 .
- FIG. 4A schematically illustrates the stomach 20 at a certain time after ingestion of liquid 22 , for example, 1-10 minutes after ingestion of liquid 22
- FIG. 4B schematically illustrates the stomach 20 a certain time after that depicted in FIG. 4A , which may be, for example, 1-50 minutes after ingestion of liquid 22
- the liquid level 27 ′ in FIG. 4B is shown to be lower than the liquid level 27 in FIG. 4A .
- device 40 may obtain images of field of view 29 and/or field of view 23 at a certain time (as seen, for example, in FIG.
- device 40 may obtain images of field of view 29 ′ and/or field of view 23 ′ (as shown, for example, in FIG. 4B ). Other fields of view may be obtained.
- device 40 may include more than one imaging system, for example, enabling counter-directional viewing.
- a floatable imaging device is inserted into a patient's body lumen, for example into the large intestine or stomach, e.g., by swallowing the imaging device.
- the patient ingests a volume of liquid, e.g., approximately 100-500 ml of a hyperosmolar liquid, water, tea, juice etc.
- the step of inserting the imaging device may be carried out by placing the device in a specific location of the GI tract, for example, by using an endoscope or another suitable inserting device.
- ingesting a volume of liquid may precede the step of inserting an imaging device or a volume of liquid can be ingested after the step of inserting an imaging device.
- the procedure may be repeated more than once.
- the step of ingesting a volume of liquid may be repeated more than once during a procedure whereas each repeat of this step (according to some embodiments after a suitable waiting period, e.g., a minute to tens of minutes between each repeated step) may include ingesting the same or different volumes of liquid and/or different or the same liquids may be used each time.
- repeating steps may be utilized for repeated visual scanning or gradual ingestion of a total volume.
- the total volume may, according to some embodiments, be from approximately 100 ml to a liter or more of liquid. Time periods, absorption periods, amounts, etc., other than specifically disclosed herein may be used. Other operations or series of operations may be used. According to other embodiments a volume of liquid may be inserted into the patient's stomach by means other than by ingesting, for example by injecting the liquid.
- images of multi-directional fields of view may be obtained, for example the field of view may be above the liquid or/and below the liquid.
- the images may be transmitted to an external receiving system, for example to the receiver 90 .
- the device 40 may be made floatable or have its specific gravity changed after insertion into a patient's body.
- an imaging device 40 may include a buoy or other floatation or weigh element that may be packaged such that it is not buoyant while in packaging. Release of the buoy from its packaging may lend buoyancy to the sensor system.
- the buoy may be released from its packaging at a desired location or point in time, such that the floatable in-vivo imaging device may acquire buoyancy according to specific requirements.
- the floatable in-vivo imaging device 40 may be ingested and moved by peristalsis through the esophagus while its buoy is packaged
- the buoy is released from its packaging (for example, by. using a pH sensitive mechanism, as known in the art, or other suitable mechanism) and the device can then float in a bulk of liquid in the stomach and be carried by the bulk of liquid to all areas of the stomach and may be carried down through the whole stomach, enabling, for example, imaging of substantially most of the stomach walls.
- the mechanisms by which the buoy is released from its packaging can be externally controlled or automatically controlled, for example, as described in embodiments described in the above mentioned U.S. application Ser. No. 10/150,492.
- FIG. 6 is a schematic flow-chart of a method of manufacturing a floatable in-vivo imaging device in accordance with some embodiments of the invention.
- the method may include manufacturing or providing a lens holder having one or more lenses, suitable for viewing through air.
- the method may include manufacturing or providing a lens holder having one or more lenses; suitable for viewing through liquid.
- the method may optionally include attaching or connecting one or more components to a support, for example a circuit board such as a rigid circuit board or a flexible circuit board or a rigid-flex circuit board.
- the method may include, for example, attaching the lens holders, an illumination source, an imager, a power source, a sensor, a transmitter, an antenna, or other suitable components
- the method may include inserting the components into a suitable housing adapted or configured for floating in endo luminal fluids and configured for in vivo imaging, for example, a housing of a swallowable capsule.
Abstract
Description
- The present invention relates to the field of in-vivo diagnostics. More specifically, the present invention relates to a device, system and method for imaging a body lumen.
- Known devices may be helpful in providing in-vivo imaging. Autonomous in-vivo imaging devices, such as swallowable or ingestible capsules or other devices may move through a body lumen, imaging as they move along. Some of these devices use a wireless connection to transmit image data. Some in-vivo imaging devices have a limited field-of-view. Some desirable portions of an in-vivo lumen may not be imaged with such fields of view.
- There is thus provided, according to embodiments of the invention, a device, system and method for imaging a body lumen. According to an embodiment of the invention there is provided a device, system and method for imaging typically voluminous, usually liquid filled body lumens, for example, the stomach.
- According to an embodiment of the invention a typically floatable imaging device, or a device having other suitable weight or mass distribution or specific gravity, is moved through a body lumen, such as the large intestine or stomach, by using the passage of a volume of liquid within and/or through the body lumen.
- According to embodiments of the invention, the floatable in-vivo imaging device, may have a specific gravity of about 1 or less, or a volume to weight ratio that enables it essentially to float, for example, in a body lumen liquid, for example the liquid typically found in the human stomach, or for example liquid that may be administered to a patient to fill a lumen such as the stomach.
- According to an embodiment of the invention the floatable imaging device may be inserted in-vivo. For example, a typically autonomous floatable device may be ingested and moved through the GI tract, typically by peristalsis. When reaching a relatively voluminous liquid filled lumen, such as the stomach, the device, which may float in the volume of liquid, may be moved through the lumen in accordance with the movement of the volume of liquid. Other embodiments may include other suitable devices and methods.
- According to a further embodiment of the invention there is provided a method for imaging body lumens, such as the large intestine or the stomach. The method according to one embodiment of the invention comprises the step of inserting a floatable in-vivo device into a patient lumen, for example by swallowing the imaging device, preferably after which a patient ingests a volume of liquid, for example water or juice. In an embodiment of the invention the method is used for imaging the stomach and may comprise the step of ingesting a composition to retrain liquids in the body lumen.
- The subject matter regarded as the invention is particularly pointed out and distinctly claimed in the concluding portion of the specification. The invention, however, both as to organization and method of operation, together with objects, features and advantages thereof, may best be understood by reference to the following detailed description when read with the accompanied drawings in which:
-
FIG. 1A is a schematic diagram of an embodiment of an in-vivo imaging device and an external receiver and transmitter system in accordance with an embodiment of the invention; -
FIG. 1B is a schematic diagram of an embodiment of an in-vivo imaging device according to another embodiment of the present invention; -
FIG. 2 is a schematic two dimensional presentation of an optical system according to an embodiment of the present invention; -
FIG. 3 is a schematic cross-sectional representation of volumes of space included in an in-vivo imaging device in accordance with an embodiment of the invention; -
FIGS. 4A and 4B are schematic illustrations of an imaging devices being moved through a body lumen in accordance with an embodiment of the invention; -
FIG. 5 is a box diagram depicting a method for in-vivo imaging according to an embodiment of the invention; and -
FIG. 6 is a schematic flow-chart of a method of manufacturing a floatable in-vivo imaging device in accordance with some embodiments of the invention. - It will be appreciated that for simplicity and clarity of illustration, elements shown in the figures have not necessarily been drawn to scale. For example, the dimensions of some of the elements may be exaggerated relative to other elements for clarity. Further, where considered appropriate, reference numerals may be repeated among the figures to indicate corresponding or analogous elements
- In the following description, various aspects of the present invention will be described. For purposes of explanation, specific configurations and details are set forth in order to provide a thorough understanding of the present invention. However, it will also be appreciated by one skilled in the art that the present invention may be practiced without the specific details presented herein. Furthermore, well known features may be omitted or simplified in order not to obscure the present invention.
- Reference is now made to
FIG. 1A , which schematically illustrates an in-vivo imaging device and system according to an embodiment of the present invention. An embodiment of the present invention may provide a floatable in-vivo imaging device 40 that can be carried byliquid 39. According to some embodiments of the present invention, theimaging device 40 may be useful in imaging lumens containing or capable of containing a bulk ofliquid 39. - According to one embodiment of the present invention,
device 40 may include two optical heads, for example two transparent empty-spaced elongatedoptical domes illumination sources 34, such as one or more LEDs (Light Emitting Diode), and/or OLEDs (Organic LED) or other illumination sources, two optical systems such aslens holders imagers device 40 may further include power source(s) 33, which may provide power to the entirety of electrical elements of the device, anantenna 31 for transmitting and receiving, for example video signals from theimagers device 40 is spherical shaped, for example), may be used - According to some embodiments of the present invention,
device 40 is capable of simultaneously obtaining images of the body lumen, for example, the stomach, from two ends of the device. For example, according to one embodiment of the present invention,device 40 may be a cylindrical capsule having a front end and a rear end, which is capable of passing the entire GI tract. - The elongated empty-
spaced domes lens holders lens holders - According to some embodiments of the
present invention device 40 may include suitable optical systems for viewing through a liquid as well as for viewing through a substantially non liquid medium. For example, a lens holder, such aslens holder 32 suitable for viewing through air (e.g. compatible with the refractive index of the air) may be placed behind transparent elongated optical dome 30 (which may be also suitable for viewing through air), while behind the transparent elongatedoptical dome 30′ may be placed a lens holder, such aslens holder 32′ suitable for viewing through liquid (e.g. compatible with the refractive index of the liquid) - According to one embodiment of the invention the in vivo imaging device has a specific gravity (SG) of about 1.0 or a volume to weight ratio that enables it essentially to float such that the
imagers device 40, and/or may be perpendicular to or substantially perpendicular to long axis A. Deviations from “horizontal” and “vertical” positions, such as angling, from long axis A or short axis B may be used. When used herein, vertical and horizontal are relative terms, and may be interchangeable based on perspectives of the viewer, or based on specific embodiments. - According to some embodiments of the present invention, outside a patient's body may be, for example, an image receiver 90 (including, for example, an antenna or an antenna array), a
storage unit 91, adata processor 92, and amonitor 93. - According to some embodiments of the present invention,
device 40 may communicate with an external receiving and display system (e.g, through receiver 90) to provide display of data, control, or other functions For example, power may be provided todevice 40 using an internal battery, an internal power source, or a wireless system to receive power. Other embodiments may have other configurations and capabilities. For example, components may be distributed over multiple sites or units, and control information may be received from an external source. - According to some embodiments of the present invention,
device 40 typically may be or may include an autonomous swallowable capsule, butdevice 40 may have other shapes and need not be swallowable or autonomous. Embodiments ofdevice 40 are typically autonomous, and are typically self-contained. For example,device 40 may be a capsule or other unit where all the components are substantially contained within a container or shell, and wheredevice 40 does not require any wires or cables to, for example, receive power or transmit information. In one embodiment, all of the components may be sealed within the device body (the body or shell may include more than one piece); for example, theimagers illumination sources 34, the power source(s), and the transmitter, may all be sealed within the device body - The system and method of the present invention may be used with or in an imaging system such as that described in U.S. patent application, Ser. No. 09/800,470, entitled A DEVICE AND SYSTEM FOR IN-VIVO IMAGING, filed on Mar. 8, 2001. A further example of an imaging system with which the system and method of the present invention may be used is described in U.S. Pat. No. 5,604,531 to Iddan et al., entitled IN-VIVO VIDEO CAMARA SYSTEM, filed on Jan. 17, 1995. Both these publications are assigned to the common assignee of the present application and are hereby incorporated by reference. Altematively, the system of the present invention may be utilized in any suitable imaging device providing images of a body lumen or cavity For example, a circuit board according to an embodiment of the invention may be utilized in probes used for in-vivo imaging, such as endoscopes.
- Reference is now made to
FIG. 1B , which schematically illustrates an in-vivo imaging device according to another embodiment of the present invention. According to one embodiment of the present invention,device 80 may include an optical head, for example a transparent empty-spaced elongatedoptical dome 94 behind which are situatedillumination sources 84, such as one or more LEDs (Light Emitting Diode), and/or OLEDs (Organic LED) or other illumination sources, an optical system such as alens holder 82 and an imager 86 (such as for example a CMOS, a CCD, etc.) a transmitter 85 (such as an RF transmitter) and/or a receiver and aprocessor 87. Thedevice 80 may further include power source(s) 83, which may provide power to the entirety of electrical elements of the device, anantenna 81 for transmitting and/or receiving. For example, the antenna may be used to transmit video signals from theimager 86. - According to some embodiments of the
present invention device 80 may include suitable optical systems for viewing through liquid. For example, thelens holder 82 may be suitable for viewing through liquid (e.g. compatible with the refractive index of the liquid). - According to some embodiments of the present invention,
device 80 may be designed such the transparent empty-spaced elongatedoptical domes 94 will always be submerged in a liquid 89, such as, for example, a typical human stomach fluid, or fluid of other body parts. For example whendevice 80 reaches, for example, the stomach lumen the transparent empty-spaced elongatedoptical domes 94 bearing the optical system compatible for under water imaging will be submerged - Reference is now made to
FIG. 2 , which is a schematic two dimensional presentation of an exemplary lens construction, according to an embodiment of the present invention. Referring toFIG. 2 , the lens construction referenced as 10 may be provided in thelens holder 32′ included in, for example,device 40 ofFIG. 1 , but may be included in other suitable devices, such as an endoscope, trocar, or other in-vivo imaging device. In the case of the particular example shown, the lens holder may include three lens elements L1, L2, and L3 suitable for viewing through liquid (e.g. compatible with the refractive index of liquid) The first lens L1 may be, for example a focusing lens such as a planoconcave lens having a flat lens surface on the side of the subject and a concave lens surface on the image-forming side. The second lens L2 which may be used for correcting aberrations may be, for example planoconvex lens L2 and may be located next to the first lens L1. Further, the third lens L3 may be a field lens such as a convex lens. Interposed between the first lens L1 and the second lens L2 may be for example an aperture, such as anaperture stop 16, which determines the amount of light which reaches an imager and/or an imager area such asimagers - According to some embodiments of the present invention, an optical design of a lens holder such as
lens holder 32, suitable for viewing through air, may be provided, by replacing one of the lens elements L1, L2, and L3 oflens holder 32′, or by changing the surface shape of one of the lens's. For example the lens construction oflens holder 32 may be formed by replacing lens L3 or by changing the surface L3′ of lens L3. Thus, changing the refractive index and the optical design of thelens construction 10, e.g. from a lens construction suitable for viewing through liquid to a lens construction suitable for viewing through air - According to some embodiments of the present invention, the refractive index and/or the optical design of a lens construction, such as
lens construction 10, may be changed by using, for example an adaptive optical lens structure such as a low control voltage liquid crystals (LCs). According to one embodiment, the length of the adaptive optical lens may be tuned from one focal length to another focal length and may provide a sharp, clean image. - Reference is now made to
FIG. 3 , which depicts a schematic cross-sectional representation of volumes of space included indevice 40. The elongated typically empty-spaced dome(s) 30 and 30′ may include one or more volumes of space empty of components, for example spaces 1. According to some embodiments of the present invention, the volume(s) of spaces 1 may be each greater than twice the volume of a central volume of space 11 which may include components that may be located at or near the center of theimaging device 40. The components comprising the central volume of space 11 may typically be thelens holders imagers - According to some embodiments of the present invention,
device 40 may be designed such that one section ofdevice 40, forexample section 50 which may include the optical system which is suitable for viewing through a liquid 39, e.goptical dome 30′lens holder 32′ andimager 36′, will be submerged in a liquid 39, such as, for example, a typical human stomach fluid, or fluid of other body parts, while the other section ofdevice 40, forexample section 50′ which may includeoptical dome 30′lens holder 32′ andimager 36′, will be exposed, bearing an optical system suitable for viewing through air which will be kept floating at all time. - According to some embodiments of the present invention, the center of gravity of
device 40 is adjusted to ensure that one side ofdevice 40, e g.section 50 will remain afloat while the other side,e.g. section 50′ will be submerged when moving through the liquid 39. For example, the center of gravity may be set in the section, or in proximity to the section of thedevice 40 that we wish to keep submerged during thedevice 40 movement. The center of gravity may be set through the positioning of certain components of thedevice 40 in desired areas, or designing thedevice 40 in a way that ensures that thedevice 40 specific weight is compatible to the shape of the outer envelope, and thus both the head and tail of thedevice 40 such as the dome(s) 30 and 30 ′ are at an angle perpendicular to the fluid. For example the components placed in the central volume of space 11 may be arranged in such a way which will result in a center of gravity located in proximity to the elongatedoptical dome 30′, which was adapted and optimized for viewing and imaging through liquid. - According to one embodiment, the empty volume(s) I and/or the central volume of space II may render the device floatable in a liquid filled lumen.
- According to one embodiment the floatable in-
vivo imaging device 40 may include one or more buoyant bod(ies) or other weight, specific gravity, ballast or mass controlling system. The buoyant body, which may be attached to the floatable in-vivo imaging device 40 or which may optionally house the floatable in-vivo imaging device and/or one or more elements of the floatable in-vivo imaging device 40, may keep the in-vivo imaging device 40 essentially floating in a liquid filled body lumen for example, in a typical human stomach fluid. Embodiments including a floatable imaging device are described, for example, in U.S. application Ser. No. 10/150,492 entitled “Floatable in-vivo Sensing Device and Method for Use” published on Jan. 23, 2003 which is assigned to the assignee of the present invention and which is hereby incorporated by reference. Other suitable specific gravity configurations or floatation systems may be used. - According to one embodiment one or more ballast(s) 38 may be included in the
device 40 for allowing one portion of thedevice 40 such assection 50, which may includelens holder 32 andimager 36, to be usually oriented in a fixed direction, for example, in a counter gravity direction. In alternate embodiments the internal components of a device may be packaged so as to shift the center of gravitand create ballast in one portion of the device, for example, batteries and electronic components may be packaged at one end of an encapsulated system so as to create ballast at that end. Furthermore, additional equipment may not be needed to, for example, alter the buoyancy or specific gravity of the device or to alter the weight distribution of the device, as such configurations may be done with components already part of the device, such as a gas such as air, CO2, N2, etc occurring within the device, etc - According to some embodiments of the present invention the
device 40 center of gravity may enable the elongated typically empty-spaced dome, such asdome 30 and an optical system, such aslens holder 32 compatible with the refractive index of the air, to float high above the fluid surface so that it is positioned above surface foam and bubbles which can interfere with image quality and field of view. According to some embodiments, when the capsule reaches, for example, the stomach lumen one side ofdevice 40 bearing the optical system compatible for under water imaging will be submerged while the other side ofdevice 40, bearing the imaging system compatible with air imaging will be held high above any interfering surface bubbles or foam, enabling clear imaging of the stomach space - Other suitable specific gravities or floating capabilities may allow for other positions of a device within a liquid volume, and other weight or mass configurations may allow for other imaging directions or orientations within a body lumen.
- Reference is now made to
FIGS. 4A and 4B , which schematically illustrate a sensing device, for example the floatable in-vivo imaging device 40, being moved through a body lumen in accordance with an embodiment of the invention According to one embodiment the floatable in-vivo imaging device 40 may be inserted into a patient'sstomach 20, for example, by swallowing. Thestomach 20 is filled with a volume ofliquid 22, which may be, for example, water, tea, juice, hyperosmolar liquid or any other suitable liquid, which is typically ingested by the patient at about the time of arrival of thedevice 40 to thestomach 20. According to some embodiments of the present invention, thefloatable imaging device 40 will be kept afloat in the liquid 22, enabling the device a multi-directional viewing ability. According to one embodiment thedevice 40 may include more than one imaging system to enable multi directional viewing and/or imaging. According to some embodiments two imagers, forexample imagers device 40, may enable multi-directional viewing and/or imaging, for example imaging above and below theliquid level 27. According to one embodiment of the present invention, multi-directional viewing ability may include illumination field and/or a field of view of the area above theliquid level 27, forexample area 29. According to other embodiments of the present invention, multi-directional viewing ability may include field of view in the opposite direction, e g. illumination field and/or a field of view of the area below theliquid level 27, forexample area 23, that may be for example filled with a volume ofliquid 22 The device may be floatable in the sense that its specific gravity is approximately the same or less than a liquid inserted into or known to be in a body lumen. Natural action of the GI tract, including the stomach, typically causes liquids to be emptied from lumens, such as the stomach, within a certain time frame. For example, liquid 22 may be naturally emptied from thestomach 20 over a period of 20-30 minutes, while moving in the direction shown, for example, byarrows 110. Thefloatable imaging device 40, which is carried by the liquid 22, will thus be moved through the stomach in the general direction of the movement ofliquid 22.FIG. 4A , for example, schematically illustrates thestomach 20 at a certain time after ingestion ofliquid 22, for example, 1-10 minutes after ingestion ofliquid 22, whereasFIG. 4B schematically illustrates the stomach 20 a certain time after that depicted inFIG. 4A , which may be, for example, 1-50 minutes after ingestion ofliquid 22. Theliquid level 27′ inFIG. 4B is shown to be lower than theliquid level 27 inFIG. 4A . Thus,device 40 may obtain images of field ofview 29 and/or field ofview 23 at a certain time (as seen, for example, inFIG. 2A ), whereas, in a certain time following that,device 40 may obtain images of field ofview 29′ and/or field ofview 23′ (as shown, for example, inFIG. 4B ). Other fields of view may be obtained. Forexample device 40 may include more than one imaging system, for example, enabling counter-directional viewing. - Reference is now made to
FIG. 5 , which schematically illustrates a method according to one embodiment of the invention. According to an embodiment of the invention, in block 310, a floatable imaging device is inserted into a patient's body lumen, for example into the large intestine or stomach, e.g., by swallowing the imaging device. In block 320 the patient ingests a volume of liquid, e.g., approximately 100-500 ml of a hyperosmolar liquid, water, tea, juice etc. According to other embodiments the step of inserting the imaging device may be carried out by placing the device in a specific location of the GI tract, for example, by using an endoscope or another suitable inserting device. According to some embodiments ingesting a volume of liquid may precede the step of inserting an imaging device or a volume of liquid can be ingested after the step of inserting an imaging device. According to some embodiments the procedure may be repeated more than once. According to some embodiments the step of ingesting a volume of liquid may be repeated more than once during a procedure whereas each repeat of this step (according to some embodiments after a suitable waiting period, e.g., a minute to tens of minutes between each repeated step) may include ingesting the same or different volumes of liquid and/or different or the same liquids may be used each time. According to some embodiments repeating steps may be utilized for repeated visual scanning or gradual ingestion of a total volume. The total volume may, according to some embodiments, be from approximately 100 ml to a liter or more of liquid. Time periods, absorption periods, amounts, etc., other than specifically disclosed herein may be used. Other operations or series of operations may be used. According to other embodiments a volume of liquid may be inserted into the patient's stomach by means other than by ingesting, for example by injecting the liquid. In block 330 images of multi-directional fields of view may be obtained, for example the field of view may be above the liquid or/and below the liquid. In step 340 the images may be transmitted to an external receiving system, for example to thereceiver 90. - According to some embodiments, the
device 40 may be made floatable or have its specific gravity changed after insertion into a patient's body. For example, animaging device 40 may include a buoy or other floatation or weigh element that may be packaged such that it is not buoyant while in packaging. Release of the buoy from its packaging may lend buoyancy to the sensor system. According to some embodiments of the present invention, the buoy may be released from its packaging at a desired location or point in time, such that the floatable in-vivo imaging device may acquire buoyancy according to specific requirements. For example, the floatable in-vivo imaging device 40 according to an embodiment of the invention may be ingested and moved by peristalsis through the esophagus while its buoy is packaged When the device enters the stomach the buoy is released from its packaging (for example, by. using a pH sensitive mechanism, as known in the art, or other suitable mechanism) and the device can then float in a bulk of liquid in the stomach and be carried by the bulk of liquid to all areas of the stomach and may be carried down through the whole stomach, enabling, for example, imaging of substantially most of the stomach walls. The mechanisms by which the buoy is released from its packaging can be externally controlled or automatically controlled, for example, as described in embodiments described in the above mentioned U.S. application Ser. No. 10/150,492. -
FIG. 6 is a schematic flow-chart of a method of manufacturing a floatable in-vivo imaging device in accordance with some embodiments of the invention. As indicated atbox 610, the method may include manufacturing or providing a lens holder having one or more lenses, suitable for viewing through air. As indicated atbox 620, the method may include manufacturing or providing a lens holder having one or more lenses; suitable for viewing through liquid. As indicated atbox 630, the method may optionally include attaching or connecting one or more components to a support, for example a circuit board such as a rigid circuit board or a flexible circuit board or a rigid-flex circuit board. This may include, for example, attaching the lens holders, an illumination source, an imager, a power source, a sensor, a transmitter, an antenna, or other suitable components As indicated atbox 640, optionally, the method may include inserting the components into a suitable housing adapted or configured for floating in endo luminal fluids and configured for in vivo imaging, for example, a housing of a swallowable capsule. - It will be appreciated by persons skilled in the art that the present invention is not limited by what has been particularly shown and described herein above. Rather the scope of the invention is defined by the claims, which follow.
Claims (22)
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US11/284,915 US8639314B2 (en) | 2003-12-24 | 2005-11-23 | Device, system and method for in-vivo imaging of a body lumen |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080300453A1 (en) * | 2005-12-28 | 2008-12-04 | Olympus Medical Systems Corp. | Intra-subject observation system and intra-subject observation method |
US20090005636A1 (en) * | 2005-11-28 | 2009-01-01 | Mport Pte Ltd | Device for Laparoscopic or Thoracoscopic Surgery |
US20090171146A1 (en) * | 2006-09-12 | 2009-07-02 | Olympus Medical Systems Corp. | Capsule endoscope |
US20090198101A1 (en) * | 2006-08-09 | 2009-08-06 | Olympus Medical Systems Corp. | Capsule endoscope |
US20090281382A1 (en) * | 2008-05-09 | 2009-11-12 | Olympus Medical Systems Corp. | Capsule medical apparatus |
US20090299144A1 (en) * | 2006-11-24 | 2009-12-03 | Olympus Medical Systems Corp. | Capsule endoscope |
US20100010305A1 (en) * | 2008-07-08 | 2010-01-14 | Olympus Medical Systems Corp. | System for guiding capsule medical device |
US20120022328A1 (en) * | 2009-02-05 | 2012-01-26 | Johannes Reinschke | Separating an endoscopy capule from a surface of a liquid |
WO2014145008A3 (en) * | 2013-03-15 | 2015-11-05 | Olive Medical Corporation | Viewing trocar for use with angled endoscope |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101351146B (en) * | 2005-12-28 | 2013-09-04 | 奥林巴斯医疗株式会社 | Into-examinee observation apparatus |
JP4827667B2 (en) * | 2006-09-07 | 2011-11-30 | オリンパスメディカルシステムズ株式会社 | Capsule endoscope |
US20080161639A1 (en) * | 2006-12-28 | 2008-07-03 | Olympus Medical Systems Corporation | Capsule medical apparatus and body-cavity observation method |
US8702591B2 (en) * | 2007-01-12 | 2014-04-22 | Olympus Medical Systems Corp. | Capsule medical apparatus |
WO2009001666A1 (en) * | 2007-06-22 | 2008-12-31 | Olympus Medical Systems Corp. | Capsule-type medical device and method of monitoring esophagus inside and stomach inside, method of monitoring stomach inside and method of washing stomach using the same |
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TWI458458B (en) * | 2012-02-24 | 2014-11-01 | Crystalvue Medical Corp | Capsule endoscope apparatus |
CN102961111B (en) * | 2012-11-07 | 2016-02-24 | 深圳市资福技术有限公司 | A kind of upright capsule endoscope |
Citations (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US486716A (en) * | 1892-11-22 | Coin-wrapper | ||
US3683389A (en) * | 1971-01-20 | 1972-08-08 | Corning Glass Works | Omnidirectional loop antenna array |
US3971362A (en) * | 1972-10-27 | 1976-07-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Miniature ingestible telemeter devices to measure deep-body temperature |
US4149769A (en) * | 1977-09-20 | 1979-04-17 | Richard Wolf Gmbh | Endoscope telescopes with tubular connected ocular and objective lens means |
US4217045A (en) * | 1978-12-29 | 1980-08-12 | Ziskind Stanley H | Capsule for photographic use in a walled organ of the living body |
US4278077A (en) * | 1978-07-27 | 1981-07-14 | Olympus Optical Co., Ltd. | Medical camera system |
US4572616A (en) * | 1982-08-10 | 1986-02-25 | Syracuse University | Adaptive liquid crystal lens |
US4588294A (en) * | 1984-06-27 | 1986-05-13 | Warner-Lambert Technologies, Inc. | Searching and measuring endoscope |
US4596050A (en) * | 1984-04-26 | 1986-06-17 | Rogers Gordon W | Information processing system using optically encoded signals |
US4689621A (en) * | 1986-03-31 | 1987-08-25 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Temperature responsive transmitter |
US4741327A (en) * | 1986-04-30 | 1988-05-03 | Olympus Optical Co., Ltd. | Endoscope having bent circuit board |
US4844076A (en) * | 1988-08-26 | 1989-07-04 | The Johns Hopkins University | Ingestible size continuously transmitting temperature monitoring pill |
US4951135A (en) * | 1988-01-11 | 1990-08-21 | Olympus Optical Co., Ltd. | Electronic-type endoscope system having capability of setting AGC variation region |
US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US5381784A (en) * | 1992-09-30 | 1995-01-17 | Adair; Edwin L. | Stereoscopic endoscope |
US5395366A (en) * | 1991-05-30 | 1995-03-07 | The State University Of New York | Sampling capsule and process |
US5459605A (en) * | 1992-12-17 | 1995-10-17 | Paul S. Kempf | 3-D endoscope apparatus |
US5575754A (en) * | 1995-02-24 | 1996-11-19 | Olympus Optical Co., Ltd. | Endoscopic apparatus for three dimensional instrumentation |
US5603687A (en) * | 1992-10-28 | 1997-02-18 | Oktas General Partnership | Asymmetric stereo-optic endoscope |
US5604531A (en) * | 1994-01-17 | 1997-02-18 | State Of Israel, Ministry Of Defense, Armament Development Authority | In vivo video camera system |
US5643175A (en) * | 1992-09-01 | 1997-07-01 | Adair; Edwin L. | Sterilizable endoscope with separable disposable tube assembly |
US5754313A (en) * | 1996-07-17 | 1998-05-19 | Welch Allyn, Inc. | Imager assembly |
US5819736A (en) * | 1994-03-24 | 1998-10-13 | Sightline Technologies Ltd. | Viewing method and apparatus particularly useful for viewing the interior of the large intestine |
US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US5940126A (en) * | 1994-10-25 | 1999-08-17 | Kabushiki Kaisha Toshiba | Multiple image video camera apparatus |
US5986693A (en) * | 1997-10-06 | 1999-11-16 | Adair; Edwin L. | Reduced area imaging devices incorporated within surgical instruments |
US5993378A (en) * | 1980-10-28 | 1999-11-30 | Lemelson; Jerome H. | Electro-optical instruments and methods for treating disease |
US6165128A (en) * | 1997-10-06 | 2000-12-26 | Endosonics Corporation | Method and apparatus for making an image of a lumen or other body cavity and its surrounding tissue |
US6184923B1 (en) * | 1994-11-25 | 2001-02-06 | Olympus Optical Co., Ltd. | Endoscope with an interchangeable distal end optical adapter |
US6211904B1 (en) * | 1997-09-11 | 2001-04-03 | Edwin L. Adair | Surgical devices incorporating reduced area imaging devices |
US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
US20010017649A1 (en) * | 1999-02-25 | 2001-08-30 | Avi Yaron | Capsule |
US6310642B1 (en) * | 1997-11-24 | 2001-10-30 | Micro-Medical Devices, Inc. | Reduced area imaging devices incorporated within surgical instruments |
US20010035902A1 (en) * | 2000-03-08 | 2001-11-01 | Iddan Gavriel J. | Device and system for in vivo imaging |
US20010051766A1 (en) * | 1999-03-01 | 2001-12-13 | Gazdzinski Robert F. | Endoscopic smart probe and method |
US20020109774A1 (en) * | 2001-01-16 | 2002-08-15 | Gavriel Meron | System and method for wide field imaging of body lumens |
US20020158976A1 (en) * | 2001-03-29 | 2002-10-31 | Vni Dov A. | Method for timing control |
US20020173718A1 (en) * | 2001-05-20 | 2002-11-21 | Mordechai Frisch | Array system and method for locating an in vivo signal source |
US20020198439A1 (en) * | 2001-06-20 | 2002-12-26 | Olympus Optical Co., Ltd. | Capsule type endoscope |
US20030011791A1 (en) * | 2001-04-05 | 2003-01-16 | Nikon Corporation | Method for image data print control, electronic camera and camera system |
US20030018280A1 (en) * | 2001-05-20 | 2003-01-23 | Shlomo Lewkowicz | Floatable in vivo sensing device and method for use |
US20030023150A1 (en) * | 2001-07-30 | 2003-01-30 | Olympus Optical Co., Ltd. | Capsule-type medical device and medical system |
US20030028078A1 (en) * | 2001-08-02 | 2003-02-06 | Arkady Glukhovsky | In vivo imaging device, system and method |
US20030114742A1 (en) * | 2001-09-24 | 2003-06-19 | Shlomo Lewkowicz | System and method for controlling a device in vivo |
US20030120130A1 (en) * | 2001-08-06 | 2003-06-26 | Arkady Glukhovsky | System and method for maneuvering a device in vivo |
US20030171649A1 (en) * | 2002-03-08 | 2003-09-11 | Takeshi Yokoi | Capsule endoscope |
US20030227547A1 (en) * | 2002-05-14 | 2003-12-11 | Iddan Gavriel J. | Optical head assembly with dome, and device for use thereof |
US6692430B2 (en) * | 2000-04-10 | 2004-02-17 | C2Cure Inc. | Intra vascular imaging apparatus |
US20040181155A1 (en) * | 2002-04-25 | 2004-09-16 | Arkady Glukhovsky | Device and method for in-vivo sensing |
US6800060B2 (en) * | 2000-11-08 | 2004-10-05 | Hewlett-Packard Development Company, L.P. | Swallowable data recorder capsule medical device |
US20040249247A1 (en) * | 2003-05-01 | 2004-12-09 | Iddan Gavriel J. | Endoscope with panoramic view |
US20040254455A1 (en) * | 2002-05-15 | 2004-12-16 | Iddan Gavriel J. | Magneic switch for use in a system that includes an in-vivo device, and method of use thereof |
US20050043583A1 (en) * | 2003-05-22 | 2005-02-24 | Reinmar Killmann | Endoscopy apparatus |
US6939295B2 (en) * | 2002-03-08 | 2005-09-06 | Olympus Corporation | Capsule endoscope |
US20070106112A1 (en) * | 2003-12-24 | 2007-05-10 | Daniel Gat | Device, system and method for in-vivo imaging of a body lumen |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5745833A (en) | 1980-09-01 | 1982-03-16 | Taeko Nakagawa | Stomack camera |
EP0228493B1 (en) | 1985-12-17 | 1991-03-20 | Warner-Lambert Technologies, Inc. | Searching and measuring endoscope |
DE3440177A1 (en) | 1984-11-02 | 1986-05-15 | Friedrich Dipl.-Ing. 8031 Eichenau Hilliges | Television recording and replay device for endoscopy on human and animal bodies |
US4867136A (en) | 1987-04-23 | 1989-09-19 | Olympus Optical Co., Ltd. | Endoscope apparatus |
JP2579372B2 (en) | 1989-12-04 | 1997-02-05 | 日本テキサス・インスツルメンツ株式会社 | Low power imaging device |
JPH04109927A (en) | 1990-08-31 | 1992-04-10 | Toshiba Corp | Electronic endoscope apparatus |
JPH04144533A (en) | 1990-10-05 | 1992-05-19 | Olympus Optical Co Ltd | Endoscope |
JP2948900B2 (en) | 1990-11-16 | 1999-09-13 | オリンパス光学工業株式会社 | Medical capsule |
JP2768029B2 (en) | 1991-02-19 | 1998-06-25 | 日新電機株式会社 | Digestive system diagnostic device |
JP3631265B2 (en) | 1994-04-27 | 2005-03-23 | オリンパス株式会社 | In-vivo observation device |
IL110475A (en) | 1994-07-27 | 2000-11-21 | Given Imaging Ltd | Optical system for flexible tubes |
GB9619470D0 (en) | 1996-09-18 | 1996-10-30 | Univ London | Imaging apparatus |
AUPO526997A0 (en) | 1997-02-25 | 1997-03-20 | Lux Trading Services Limited | Griller unit |
WO1998051993A1 (en) | 1997-05-16 | 1998-11-19 | Olympus Optical Co., Ltd. | Height-measuring device |
IL126727A (en) | 1998-10-22 | 2006-12-31 | Given Imaging Ltd | Method for delivering a device to a target location |
JP3490933B2 (en) | 1999-06-07 | 2004-01-26 | ペンタックス株式会社 | Swallowable endoscope device |
IL143258A0 (en) | 2001-05-20 | 2002-04-21 | Given Imaging Ltd | A method for in vivo imaging of the gastrointestinal tract in unmodified conditions |
IL130486A (en) | 1999-06-15 | 2005-08-31 | Given Imaging Ltd | Optical system |
GB2352636B (en) | 1999-08-03 | 2003-05-14 | Univ College London Hospitals | Improved passage-travelling device |
JP4472069B2 (en) | 1999-11-10 | 2010-06-02 | オリンパス株式会社 | Medical capsule endoscope |
JP4573393B2 (en) | 2000-01-06 | 2010-11-04 | オリンパス株式会社 | Image display device |
IL134017A (en) | 2000-01-13 | 2008-04-13 | Capsule View Inc | Camera for viewing inside intestines |
JP4338280B2 (en) | 2000-02-15 | 2009-10-07 | Hoya株式会社 | Capsule endoscope |
JP2001224553A (en) | 2000-02-17 | 2001-08-21 | Asahi Optical Co Ltd | Imaging instrument for capusle endoscope |
AU2002225304A1 (en) | 2001-01-11 | 2002-07-24 | Given Imaging Ltd. | Device and system for in-vivo procedures |
ATE404114T1 (en) | 2001-06-18 | 2008-08-15 | Given Imaging Ltd | SWALLOWABLE IN-VIVO CAPSULE WITH A CIRCUIT BOARD HAVING RIGID AND FLEXIBLE SECTIONS |
EP1421775A4 (en) | 2001-06-28 | 2009-12-23 | Given Imaging Ltd | In vivo imaging device with a small cross sectional area and methods for construction thereof |
AU2002324308A1 (en) | 2001-08-02 | 2003-02-17 | Given Imaging Ltd. | Apparatus and methods for in vivo imaging |
JP2003260025A (en) | 2002-03-08 | 2003-09-16 | Olympus Optical Co Ltd | Capsule endoscope |
US7085070B2 (en) | 2002-05-14 | 2006-08-01 | Olympus Corporation | Zoom lens and electronic imaging device having the same |
JP4109927B2 (en) | 2002-08-20 | 2008-07-02 | セイコークロック株式会社 | Radio correction watch and method |
US7662093B2 (en) | 2002-09-30 | 2010-02-16 | Given Imaging, Ltd. | Reduced size imaging device |
AU2003269438A1 (en) | 2002-09-30 | 2004-04-19 | Given Imaging Ltd. | In-vivo sensing system |
JP2006509574A (en) | 2002-12-16 | 2006-03-23 | ギブン イメージング リミテッド | Apparatus, system, and method for selective actuation of in-vivo sensors |
JP5015515B2 (en) | 2006-08-02 | 2012-08-29 | 伊藤超短波株式会社 | Muscle training equipment |
-
2005
- 2005-11-23 US US11/284,915 patent/US8639314B2/en not_active Expired - Fee Related
-
2006
- 2006-11-19 WO PCT/IL2006/001331 patent/WO2007060656A2/en active Application Filing
Patent Citations (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US486716A (en) * | 1892-11-22 | Coin-wrapper | ||
US3683389A (en) * | 1971-01-20 | 1972-08-08 | Corning Glass Works | Omnidirectional loop antenna array |
US3971362A (en) * | 1972-10-27 | 1976-07-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Miniature ingestible telemeter devices to measure deep-body temperature |
US4149769A (en) * | 1977-09-20 | 1979-04-17 | Richard Wolf Gmbh | Endoscope telescopes with tubular connected ocular and objective lens means |
US4278077A (en) * | 1978-07-27 | 1981-07-14 | Olympus Optical Co., Ltd. | Medical camera system |
US4217045A (en) * | 1978-12-29 | 1980-08-12 | Ziskind Stanley H | Capsule for photographic use in a walled organ of the living body |
US5993378A (en) * | 1980-10-28 | 1999-11-30 | Lemelson; Jerome H. | Electro-optical instruments and methods for treating disease |
US4572616A (en) * | 1982-08-10 | 1986-02-25 | Syracuse University | Adaptive liquid crystal lens |
US4596050A (en) * | 1984-04-26 | 1986-06-17 | Rogers Gordon W | Information processing system using optically encoded signals |
US4588294A (en) * | 1984-06-27 | 1986-05-13 | Warner-Lambert Technologies, Inc. | Searching and measuring endoscope |
US4689621A (en) * | 1986-03-31 | 1987-08-25 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Temperature responsive transmitter |
US4741327A (en) * | 1986-04-30 | 1988-05-03 | Olympus Optical Co., Ltd. | Endoscope having bent circuit board |
US4951135A (en) * | 1988-01-11 | 1990-08-21 | Olympus Optical Co., Ltd. | Electronic-type endoscope system having capability of setting AGC variation region |
US4844076A (en) * | 1988-08-26 | 1989-07-04 | The Johns Hopkins University | Ingestible size continuously transmitting temperature monitoring pill |
US5395366A (en) * | 1991-05-30 | 1995-03-07 | The State University Of New York | Sampling capsule and process |
US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US5643175A (en) * | 1992-09-01 | 1997-07-01 | Adair; Edwin L. | Sterilizable endoscope with separable disposable tube assembly |
US5381784A (en) * | 1992-09-30 | 1995-01-17 | Adair; Edwin L. | Stereoscopic endoscope |
US5603687A (en) * | 1992-10-28 | 1997-02-18 | Oktas General Partnership | Asymmetric stereo-optic endoscope |
US5459605A (en) * | 1992-12-17 | 1995-10-17 | Paul S. Kempf | 3-D endoscope apparatus |
US5604531A (en) * | 1994-01-17 | 1997-02-18 | State Of Israel, Ministry Of Defense, Armament Development Authority | In vivo video camera system |
US5819736A (en) * | 1994-03-24 | 1998-10-13 | Sightline Technologies Ltd. | Viewing method and apparatus particularly useful for viewing the interior of the large intestine |
US5940126A (en) * | 1994-10-25 | 1999-08-17 | Kabushiki Kaisha Toshiba | Multiple image video camera apparatus |
US6184923B1 (en) * | 1994-11-25 | 2001-02-06 | Olympus Optical Co., Ltd. | Endoscope with an interchangeable distal end optical adapter |
US5575754A (en) * | 1995-02-24 | 1996-11-19 | Olympus Optical Co., Ltd. | Endoscopic apparatus for three dimensional instrumentation |
US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US5754313A (en) * | 1996-07-17 | 1998-05-19 | Welch Allyn, Inc. | Imager assembly |
US6211904B1 (en) * | 1997-09-11 | 2001-04-03 | Edwin L. Adair | Surgical devices incorporating reduced area imaging devices |
US6165128A (en) * | 1997-10-06 | 2000-12-26 | Endosonics Corporation | Method and apparatus for making an image of a lumen or other body cavity and its surrounding tissue |
US5986693A (en) * | 1997-10-06 | 1999-11-16 | Adair; Edwin L. | Reduced area imaging devices incorporated within surgical instruments |
US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
US6310642B1 (en) * | 1997-11-24 | 2001-10-30 | Micro-Medical Devices, Inc. | Reduced area imaging devices incorporated within surgical instruments |
US20010017649A1 (en) * | 1999-02-25 | 2001-08-30 | Avi Yaron | Capsule |
US20010051766A1 (en) * | 1999-03-01 | 2001-12-13 | Gazdzinski Robert F. | Endoscopic smart probe and method |
US20020103417A1 (en) * | 1999-03-01 | 2002-08-01 | Gazdzinski Robert F. | Endoscopic smart probe and method |
US20010035902A1 (en) * | 2000-03-08 | 2001-11-01 | Iddan Gavriel J. | Device and system for in vivo imaging |
US6692430B2 (en) * | 2000-04-10 | 2004-02-17 | C2Cure Inc. | Intra vascular imaging apparatus |
US6800060B2 (en) * | 2000-11-08 | 2004-10-05 | Hewlett-Packard Development Company, L.P. | Swallowable data recorder capsule medical device |
US20020109774A1 (en) * | 2001-01-16 | 2002-08-15 | Gavriel Meron | System and method for wide field imaging of body lumens |
US20020158976A1 (en) * | 2001-03-29 | 2002-10-31 | Vni Dov A. | Method for timing control |
US20030011791A1 (en) * | 2001-04-05 | 2003-01-16 | Nikon Corporation | Method for image data print control, electronic camera and camera system |
US20030018280A1 (en) * | 2001-05-20 | 2003-01-23 | Shlomo Lewkowicz | Floatable in vivo sensing device and method for use |
US20020173718A1 (en) * | 2001-05-20 | 2002-11-21 | Mordechai Frisch | Array system and method for locating an in vivo signal source |
US7192397B2 (en) * | 2001-05-20 | 2007-03-20 | Given Imaging Ltd. | Floatable in vivo sensing device and method for use |
US20020198439A1 (en) * | 2001-06-20 | 2002-12-26 | Olympus Optical Co., Ltd. | Capsule type endoscope |
US20030023150A1 (en) * | 2001-07-30 | 2003-01-30 | Olympus Optical Co., Ltd. | Capsule-type medical device and medical system |
US20030028078A1 (en) * | 2001-08-02 | 2003-02-06 | Arkady Glukhovsky | In vivo imaging device, system and method |
US20030120130A1 (en) * | 2001-08-06 | 2003-06-26 | Arkady Glukhovsky | System and method for maneuvering a device in vivo |
US20030114742A1 (en) * | 2001-09-24 | 2003-06-19 | Shlomo Lewkowicz | System and method for controlling a device in vivo |
US20030171649A1 (en) * | 2002-03-08 | 2003-09-11 | Takeshi Yokoi | Capsule endoscope |
US6939295B2 (en) * | 2002-03-08 | 2005-09-06 | Olympus Corporation | Capsule endoscope |
US20040181155A1 (en) * | 2002-04-25 | 2004-09-16 | Arkady Glukhovsky | Device and method for in-vivo sensing |
US20030227547A1 (en) * | 2002-05-14 | 2003-12-11 | Iddan Gavriel J. | Optical head assembly with dome, and device for use thereof |
US20040254455A1 (en) * | 2002-05-15 | 2004-12-16 | Iddan Gavriel J. | Magneic switch for use in a system that includes an in-vivo device, and method of use thereof |
US20040249247A1 (en) * | 2003-05-01 | 2004-12-09 | Iddan Gavriel J. | Endoscope with panoramic view |
US20050043583A1 (en) * | 2003-05-22 | 2005-02-24 | Reinmar Killmann | Endoscopy apparatus |
US20070106112A1 (en) * | 2003-12-24 | 2007-05-10 | Daniel Gat | Device, system and method for in-vivo imaging of a body lumen |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8409076B2 (en) * | 2005-11-28 | 2013-04-02 | Mport Pte Ltd | Device for laparoscopic or thoracoscopic surgery |
US20090005636A1 (en) * | 2005-11-28 | 2009-01-01 | Mport Pte Ltd | Device for Laparoscopic or Thoracoscopic Surgery |
US20080300453A1 (en) * | 2005-12-28 | 2008-12-04 | Olympus Medical Systems Corp. | Intra-subject observation system and intra-subject observation method |
US8632459B2 (en) * | 2005-12-28 | 2014-01-21 | Olympus Medical Sytems Corp. | Intra-subject observation system and intra-subject observation method |
US20090198101A1 (en) * | 2006-08-09 | 2009-08-06 | Olympus Medical Systems Corp. | Capsule endoscope |
US20090171146A1 (en) * | 2006-09-12 | 2009-07-02 | Olympus Medical Systems Corp. | Capsule endoscope |
US8419614B2 (en) * | 2006-09-12 | 2013-04-16 | Olympus Medical Systems Corp. | Capsule endoscope |
US20090299144A1 (en) * | 2006-11-24 | 2009-12-03 | Olympus Medical Systems Corp. | Capsule endoscope |
US8439822B2 (en) * | 2006-11-24 | 2013-05-14 | Olympus Medical Systems Corp. | Capsule endoscope |
US20090281382A1 (en) * | 2008-05-09 | 2009-11-12 | Olympus Medical Systems Corp. | Capsule medical apparatus |
US8235888B2 (en) * | 2008-07-08 | 2012-08-07 | Olympus Medical Systems Corp. | System for guiding capsule medical device |
US20100010305A1 (en) * | 2008-07-08 | 2010-01-14 | Olympus Medical Systems Corp. | System for guiding capsule medical device |
US9095261B2 (en) | 2008-07-08 | 2015-08-04 | Olympus Medical Systems Corp. | System for guiding capsule medical device |
US20120022328A1 (en) * | 2009-02-05 | 2012-01-26 | Johannes Reinschke | Separating an endoscopy capule from a surface of a liquid |
US9125576B2 (en) * | 2009-02-05 | 2015-09-08 | Siemens Aktiengesellschaft | Separating endoscopy capsule from surface of liquid |
WO2014145008A3 (en) * | 2013-03-15 | 2015-11-05 | Olive Medical Corporation | Viewing trocar for use with angled endoscope |
US10561302B2 (en) | 2013-03-15 | 2020-02-18 | DePuy Synthes Products, Inc. | Viewing trocar with integrated prism for use with angled endoscope |
US11690498B2 (en) | 2013-03-15 | 2023-07-04 | DePuy Synthes Products, Inc. | Viewing trocar with integrated prism for use with angled endoscope |
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WO2007060656A3 (en) | 2009-08-27 |
US8639314B2 (en) | 2014-01-28 |
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