US20120073509A1 - Mask for analyzed mammals - Google Patents
Mask for analyzed mammals Download PDFInfo
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- US20120073509A1 US20120073509A1 US13/241,344 US201113241344A US2012073509A1 US 20120073509 A1 US20120073509 A1 US 20120073509A1 US 201113241344 A US201113241344 A US 201113241344A US 2012073509 A1 US2012073509 A1 US 2012073509A1
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- elsm
- anesthetization
- fsm
- agm
- mask
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
Definitions
- the present invention generally pertains to masks for behavior of mammals, such as anesthetized mice and rats, scanned within an MRI device.
- the invention also relates to methods of treating mammals during the study thereof and to methods for reducing exposure of laboratory personnel to hazardous fluids.
- MRI-compatible anesthesia gas masks for animals and MRI-compatible platforms for animal surgery are commercially available items; see for example products of Stoelting Co (US), 2Biological Instruments (IT) etc.
- these gas anesthesia platforms and mouse, rat, dog etc. masks provide easy positioning of an animal during anesthesia and surgery and often allow for anesthetization and positioning of the animal outside of a stereotaxic device and for dorsal surgery.
- the animal's teeth are usually placed over an incisor bar and the mask slid forward until the cone fits snugly around the animal's nose, so that no nose clamp is required.
- the platform is then lifted onto an appropriate stereotaxic device, providing positioning of the animal.
- the head of the animal is not perfectly conical, however.
- US patent application 2004/0216737 discloses an anesthesia system for administering an anesthetic gas to the nose of an animal.
- the anesthesia system comprises a mask having a receptacle adapted to surround and form a fluid path to the animal's nose; a breather enclosure forming an air exchange chamber, the breather enclosure comprising a connector configured for coupling with the mask to connect the receptacle and air exchange chamber in fluid communication; an inlet hub extending inside the air exchange chamber and forming an inlet port through a wall in the breather enclosure, the inlet port being adapted to convey the anesthetic gas into the chamber and to the mask; and a check valve connected with the inlet hub and extending within the air exchange chamber, the check valve being operable in response to relative pressure in the air exchange chamber between an open position, which permits anesthetic gas to enter the air exchange chamber, and a closed position, which substantially prevents anesthetic gas from entering the air exchange chamber, wherein the check valve moves to the open position in response to vacuum pressure created when
- U.S. Pat. No. 6,363,931 discloses an occluder for supporting and preventing escape of anesthesia gases through face masks when not in use, comprising: a C-shaped support base with a flat base plate adapted to fit beneath a surgical mattress, a side plate located in a plane normal to that of the base plate having a bottom edge contiguous with the base plate and having a height equal to the thickness of a standard surgical mattress, and a top plate contiguous with an upper edge of the side plate, the top plate being in a plane parallel to that of the base plate; and a solid cylindrical support shaft supported on and extending upwardly from the top plate, the cylindrical support shaft having a main body portion approximately 15 mm in diameter.
- U.S. Pat. No. 4,633,890 discloses an apparatus for preventing the undesirable egress of anesthetic gas into ambient atmosphere, comprising a tube having one end connected to an anesthesia machine and its second end being a free end; the anesthesia machine supplying anesthetic gas to the tube; the free end being removably connectable to a breathing passage of a patient; an obturator post connected to the anesthesia machine and constructed to sealingly engage the free end, for preventing the undesirable egress of the anesthetic gas into the atmosphere of an operating theater when the free end is disconnected from the breathing passage; and a bore passing through the obturator post and communicating with exhaust means.
- an anesthetization gas mask characterized by a cup with conic cross section, comprising a plurality of apertures located at the outer circumference of the cup.
- Another object of the invention is to disclose the AGM as defined above, wherein the mask is made of MRI-compatible materials.
- Another object of the invention is to disclosed the AGM as defined above, wherein the MRI-compatible materials are polymers.
- Another object of the invention is to disclose the AGM as defined above, wherein the mask is adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclosed the AGM as defined above, wherein said animals are laboratory animals.
- Another object of the invention is to disclose an anesthetization system comprising an AGM as defined above, a fluid supplying mechanism (FSM) accommodating the same, wherein the FSM is in continuous fluid communication with the anesthetization gas inlet and outlet, and an air suction outlet.
- FSM fluid supplying mechanism
- Another object of the invention is to disclose an anesthetization system comprising an AGM as defined above, wherein the system further comprises a mask maneuvering mechanism comprising an adjustment knob in connection with the mask, the knob is adapted to ensure that the mask remains in a predefined location within a housing of the FSM.
- the ELSM comprises a cradle or bed adapted by means of size and shape to accommodate the animal; an anesthetization gas mask (AGM) characterized by a cup with a substantially conical cross section, comprising a plurality of apertures located at the outer circumference of the cup; a fluid supplying mechanism (FSM) in which the AGM is placed, the FSM is in a continuous fluid communication with (i) an anesthetization gas inlet positioned outside the ELSM and an outlet located within the ELSM; (ii) an air suction scavenging device positioned outside the ELSM and a mask and an air suction outlet located within the ELSM; and optionally (iii) a plurality of air conditioning tubes; and an airtight shell enveloping the same.
- AGM anesthetization gas mask
- FSM fluid supplying mechanism
- the airtight ELSM prevents leakage of anesthetization gas from the ELSM outwardly to the laboratory; provides thermal isolation between ambient air and the air-conditioned animal environment; and prevents accidental spillage of hazardous materials such as, e.g., radioactive agents, outside the environment in which the animal is accommodated.
- Another object of the invention is to disclose an MRI-compatible ELSM and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclose and MRI-compatible ELSM, and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals, wherein said animals are laboratory animals.
- Another object of the invention is to disclose a mouse handling system (MHS) comprising an encapsulatable life support mechanism (ELSM) for an analyzed animal;
- the MHS is a maneuverable elongated device, characterized by a proximal portion, held outside the MRI device, and comprises at least one inner shaft and at least one outer shaft, the at least one outer shaft telescopically maneuverable along the at least one inner shaft to provide a telescopic mechanism of variable (proximal-) length;
- the MHS is further characterized by a distal portion comprising the ELSM, wherein the distal ELSM is rotatable and/or linearly reciprocatable along the main longitudinal axis of the shafts by means of the maneuverable telescopic mechanism of the proximal portion.
- Another object of the invention is to disclose an MRI-compatible MHS and an MHS wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclose an MRI-compatible MHS and an MHS wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals, wherein said animals are laboratory animals.
- Another object of the invention is to disclose an MRI-compatible ELSM and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclose an MRI-compatible ELSM and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals, wherein said animals are laboratory animals.
- Another object of the invention is to disclose a safe method for forming an airtight capsule to prevent leakage of anesthetization gas from the gas supply inlets to the laboratory; and/or to prevent accidental spillage of hazardous materials, e.g. radioactive agents, outside of the environment enclosing the animals; the method comprising steps of providing a mouse handling system (MHS) which is a maneuverable elongated device comprising an encapsulatable life support mechanism (ELSM) for the analyzed animal; characterizing the same by a proximal portion, held outside the MRI device, comprising at least one inner shaft and at least one outer shaft, the at least one outer shaft telescopically maneuverable along the at least one inner shaft to provide a telescopic mechanism of variable (proximal-) length; and further characterizing the same by a distal portion comprising the ELSM.
- the distal ELSM is rotatable and/or linearly reciprocatable along the main longitudinal axis of the shafts by means of the maneuverable tele
- Another object of the invention is to disclose a safe method for preventing leakage of anesthetization gas from the gas supply inlets to the laboratory.
- the method comprises steps of providing an anesthetization gas mask (AGM); further characterizing the same by a cup with substantially conical cross section; and providing plurality of apertures located at the outer circumference of the cup.
- AGM anesthetization gas mask
- FIG. 1 shows an MRD device including at least one port for use inserting therein a Mouse Handling System (MHS), in accordance with a preferred embodiment of the present invention
- MHS Mouse Handling System
- FIG. 2 shows the MHS including sealing flanges and a mouse holding portion, in accordance with a preferred embodiment of the present invention
- FIG. 3 shows the details of the proximal portion of the MHS, in accordance with a preferred embodiment of the present invention
- FIG. 4 shows the location of the mouse within the MHS, in accordance with a preferred embodiment of the present invention
- FIG. 5 shows the details of the distal portion of the MHS, in accordance with a preferred embodiment of the present invention
- FIGS. 6 a and 6 b show the flushing air device, in accordance with a preferred embodiment of the present invention.
- FIG. 7 shows a conic mask 32 , in accordance with a preferred embodiment of the present invention.
- Magnetic Resonance Device specifically applies hereinafter to any Magnetic Resonance Imaging (MRI) device, any Nuclear Magnetic Resonance (NMR) spectroscope, any Electron Spin Resonance (ESR) spectroscope, any Nuclear Quadruple Resonance (NQR) spectroscope or any combination thereof.
- the MRD hereby disclosed is optionally a portable MRI device, such as the ASPECT Magnet Technologies Ltd commercially available devices, or a commercially available non-portable device.
- the term ‘MRD’ generally refers in this patent to any medical device, at least temporary accommodating an anesthetized animal.
- FIG. 1 schematically illustrating, not to scale, an MRI device, such as an MRD 10 , comprising at least one port 110 .
- a mouse handling system (MHS, 100 ), which is a maneuverable elongated device, is inserted through the port 10 .
- the MHS 100 is characterized by a substantially circular cross-section and a proximal portion 20 , which is located outside the MRD 10 .
- the MHS 100 further includes a shaft 21 , and a distal portion 30 (see FIG. 2 ).
- the maneuverable MHS 100 is rotatable about longitudinal axis of the shaft 21 ( FIGS. 1 and 2 ) and is translationally maneuverable parallel to the shaft 21 .
- the proximal end 20 is slideable over the shaft 21 , providing a telescopic mechanism of variable length.
- the MHS 100 includes the flange 11 a and a flange 11 b , located at a distal opposite end of the MHS 100 .
- the MHS 100 is inserted into port 110 of the MRD 10 .
- the proximal portion 20 of MHS 100 comprises a plurality of levers and handles ( 22 a and 22 b ) which lock the location of the maneuverable MHS 100 , within the MRD 10 and a connection mechanism adapted to communicate the encapsulated environment of the distal portion 30 with the proximal portion 20 , by means of a plurality of fluid-connecting pipes (not shown here).
- the proximal end 20 of MHS 100 comprises a plurality of indicia, such as a rotation indication 23 b , positioned on the shaft 21 indicates the angular and translational relative position of the MHS 100 with respect to MRD 10 .
- the proximal portion 20 of the MHS 100 includes an airtight capsule 30 comprising a shell 22 , an animal bed or cradle 31 , for locating an animal 1 to be studied as well as a fluid supplying mechanism 33 .
- the role of shell 22 is (i) to form an airtight capsule to prevent leakage of anesthetization gas from the gas supply inlets to the laboratory environment; (ii) to provide thermal isolation between the laboratory environment the air-conditioned environment surrounding the animal in the shell 22 and the laboratory environment; and (iii) to prevent accidental spillage of hazardous materials, e.g. radioactive agents outside the shell 22 surrounding the animal.
- hazardous materials e.g. radioactive agents outside the shell 22 surrounding the animal.
- FIG. 3 schematically illustrating, not to scale, the proximal portion 20 of MHS 100 , which comprises the shaft 21 upon which a translational scale 22 a and a rotation scale 23 b are positioned, and a distal portion 30 (here without shell 20 ), where mouse 1 is lying thereon the cradle 31 .
- FIG. 4 schematically illustrating, not to scale, the distal portion 30 .
- the mouse 1 is immobilized on the cradle 31 and its head is placed within a mask 32 .
- the position of the mask 32 within a housing 33 is determined by means of rotatable rod 34 .
- the cradle 31 comprises a heating/cooling mechanism 38 .
- Mask 32 may comprise mouthpiece 35 and anesthetization gas outlet 35 a in fluid communication with anesthetization gas inlet 35 b .
- Mask 32 is located within a housing of fluid supply mechanism 33 , and its position is accurately determined by rod 34 .
- Anesthetization gas is supplied to the animal via inlet 36 a with flow f (cm 3 /sec). Air suction is provided from the mask 32 and apertures thereon (not shown) via inner portion of the housing 33 to suction outlet 37 with flow F, wherein F>>f. Hence, leakage of anesthetization gas from outlet 36 a and the inner portion of capsule 22 to the external environment of the laboratory is avoided.
- FIGS. 6 a and 6 b schematically illustrating, not to scale, the facilitated flow of flushing air device.
- the flow begins from the behind anesthetization gas inlet 36 a and passes around the animal's head via mask 32 and plurality of apertures 32 a into the Bernoulli-type orifice 32 b (orifice 32 b is narrow relative to the widest diameter of the mask), via a hollow chamber 33 a of the housing 33 , to an outlet 37 and to a gas scavenger located outside the MRD.
- FIG. 7 schematically illustrating, not to scale, a conic mask 32 and its plurality of apertures 32 a , a Bernoulli-type orifice 32 b (orifice 32 b is narrow relative to the widest diameter of mask), and adapter 32 c which couples the mask 32 to the housing 33 in a maneuverable manner.
- the role of apertures 32 a located in the outer circumference of the mask is to ensure effective flushing of air due to the irregular geometry of the animal's head 1 , and to avoid blocking of air suction by the animal's body parts and fur.
Abstract
Description
- The present invention generally pertains to masks for behavior of mammals, such as anesthetized mice and rats, scanned within an MRI device. The invention also relates to methods of treating mammals during the study thereof and to methods for reducing exposure of laboratory personnel to hazardous fluids.
- MRI-compatible anesthesia gas masks for animals and MRI-compatible platforms for animal surgery are commercially available items; see for example products of Stoelting Co (US), 2Biological Instruments (IT) etc. As designed by their producers, these gas anesthesia platforms and mouse, rat, dog etc. masks provide easy positioning of an animal during anesthesia and surgery and often allow for anesthetization and positioning of the animal outside of a stereotaxic device and for dorsal surgery. The animal's teeth are usually placed over an incisor bar and the mask slid forward until the cone fits snugly around the animal's nose, so that no nose clamp is required. The platform is then lifted onto an appropriate stereotaxic device, providing positioning of the animal. The head of the animal is not perfectly conical, however. Eyes, ears and other organs of the animal do not perfectly fit the conical mask, and hazardous leakage of anesthetization gas often occurs within the close environment of the laboratory. Cases in which laboratory personnel collapsed after breathing anesthetization gas applied to experimental animals have been reported in the literature.
- US patent application 2004/0216737 discloses an anesthesia system for administering an anesthetic gas to the nose of an animal. The anesthesia system comprises a mask having a receptacle adapted to surround and form a fluid path to the animal's nose; a breather enclosure forming an air exchange chamber, the breather enclosure comprising a connector configured for coupling with the mask to connect the receptacle and air exchange chamber in fluid communication; an inlet hub extending inside the air exchange chamber and forming an inlet port through a wall in the breather enclosure, the inlet port being adapted to convey the anesthetic gas into the chamber and to the mask; and a check valve connected with the inlet hub and extending within the air exchange chamber, the check valve being operable in response to relative pressure in the air exchange chamber between an open position, which permits anesthetic gas to enter the air exchange chamber, and a closed position, which substantially prevents anesthetic gas from entering the air exchange chamber, wherein the check valve moves to the open position in response to vacuum pressure created when the animal inhales, the check valve being normally biased in the closed position.
- U.S. Pat. No. 6,363,931 discloses an occluder for supporting and preventing escape of anesthesia gases through face masks when not in use, comprising: a C-shaped support base with a flat base plate adapted to fit beneath a surgical mattress, a side plate located in a plane normal to that of the base plate having a bottom edge contiguous with the base plate and having a height equal to the thickness of a standard surgical mattress, and a top plate contiguous with an upper edge of the side plate, the top plate being in a plane parallel to that of the base plate; and a solid cylindrical support shaft supported on and extending upwardly from the top plate, the cylindrical support shaft having a main body portion approximately 15 mm in diameter.
- U.S. Pat. No. 4,633,890 discloses an apparatus for preventing the undesirable egress of anesthetic gas into ambient atmosphere, comprising a tube having one end connected to an anesthesia machine and its second end being a free end; the anesthesia machine supplying anesthetic gas to the tube; the free end being removably connectable to a breathing passage of a patient; an obturator post connected to the anesthesia machine and constructed to sealingly engage the free end, for preventing the undesirable egress of the anesthetic gas into the atmosphere of an operating theater when the free end is disconnected from the breathing passage; and a bore passing through the obturator post and communicating with exhaust means.
- None of the above provides a simple solution for anesthetization and precise positioning of the animal within an MRI device. Hence an MRI-compatible and safe mask would fulfill a long felt need.
- It is thus one object of the invention to disclose an anesthetization gas mask (AGM) characterized by a cup with conic cross section, comprising a plurality of apertures located at the outer circumference of the cup.
- Another object of the invention is to disclose the AGM as defined above, wherein the mask is made of MRI-compatible materials.
- Another object of the invention is to disclosed the AGM as defined above, wherein the MRI-compatible materials are polymers.
- Another object of the invention is to disclose the AGM as defined above, wherein the mask is adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclosed the AGM as defined above, wherein said animals are laboratory animals.
- Another object of the invention is to disclose an anesthetization system comprising an AGM as defined above, a fluid supplying mechanism (FSM) accommodating the same, wherein the FSM is in continuous fluid communication with the anesthetization gas inlet and outlet, and an air suction outlet.
- Another object of the invention is to disclose an anesthetization system comprising an AGM as defined above, wherein the system further comprises a mask maneuvering mechanism comprising an adjustment knob in connection with the mask, the knob is adapted to ensure that the mask remains in a predefined location within a housing of the FSM.
- Another object of the invention is to disclose an encapsulatable life support mechanism (ELSM) for an analyzed animal. The ELSM comprises a cradle or bed adapted by means of size and shape to accommodate the animal; an anesthetization gas mask (AGM) characterized by a cup with a substantially conical cross section, comprising a plurality of apertures located at the outer circumference of the cup; a fluid supplying mechanism (FSM) in which the AGM is placed, the FSM is in a continuous fluid communication with (i) an anesthetization gas inlet positioned outside the ELSM and an outlet located within the ELSM; (ii) an air suction scavenging device positioned outside the ELSM and a mask and an air suction outlet located within the ELSM; and optionally (iii) a plurality of air conditioning tubes; and an airtight shell enveloping the same. The airtight ELSM prevents leakage of anesthetization gas from the ELSM outwardly to the laboratory; provides thermal isolation between ambient air and the air-conditioned animal environment; and prevents accidental spillage of hazardous materials such as, e.g., radioactive agents, outside the environment in which the animal is accommodated.
- Another object of the invention is to disclose an MRI-compatible ELSM and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclose and MRI-compatible ELSM, and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals, wherein said animals are laboratory animals.
- Another object of the invention is to disclose a mouse handling system (MHS) comprising an encapsulatable life support mechanism (ELSM) for an analyzed animal; the MHS is a maneuverable elongated device, characterized by a proximal portion, held outside the MRI device, and comprises at least one inner shaft and at least one outer shaft, the at least one outer shaft telescopically maneuverable along the at least one inner shaft to provide a telescopic mechanism of variable (proximal-) length; the MHS is further characterized by a distal portion comprising the ELSM, wherein the distal ELSM is rotatable and/or linearly reciprocatable along the main longitudinal axis of the shafts by means of the maneuverable telescopic mechanism of the proximal portion.
- Another object of the invention is to disclose an MRI-compatible MHS and an MHS wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclose an MRI-compatible MHS and an MHS wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals, wherein said animals are laboratory animals.
- Another object of the invention is to disclose an MRI-compatible ELSM and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals.
- Another object of the invention is to disclose an MRI-compatible ELSM and an ELSM wherein the AGN, FSM and mechanisms thereof are adapted by means of size and shape, to ensure anesthetization of animals, wherein said animals are laboratory animals.
- Another object of the invention is to disclose a safe method for forming an airtight capsule to prevent leakage of anesthetization gas from the gas supply inlets to the laboratory; and/or to prevent accidental spillage of hazardous materials, e.g. radioactive agents, outside of the environment enclosing the animals; the method comprising steps of providing a mouse handling system (MHS) which is a maneuverable elongated device comprising an encapsulatable life support mechanism (ELSM) for the analyzed animal; characterizing the same by a proximal portion, held outside the MRI device, comprising at least one inner shaft and at least one outer shaft, the at least one outer shaft telescopically maneuverable along the at least one inner shaft to provide a telescopic mechanism of variable (proximal-) length; and further characterizing the same by a distal portion comprising the ELSM. The distal ELSM is rotatable and/or linearly reciprocatable along the main longitudinal axis of the shafts by means of the maneuverable telescopic mechanism of the proximal portion.
- Another object of the invention is to disclose a safe method for preventing leakage of anesthetization gas from the gas supply inlets to the laboratory. The method comprises steps of providing an anesthetization gas mask (AGM); further characterizing the same by a cup with substantially conical cross section; and providing plurality of apertures located at the outer circumference of the cup.
-
FIG. 1 shows an MRD device including at least one port for use inserting therein a Mouse Handling System (MHS), in accordance with a preferred embodiment of the present invention; -
FIG. 2 shows the MHS including sealing flanges and a mouse holding portion, in accordance with a preferred embodiment of the present invention; -
FIG. 3 shows the details of the proximal portion of the MHS, in accordance with a preferred embodiment of the present invention; -
FIG. 4 shows the location of the mouse within the MHS, in accordance with a preferred embodiment of the present invention; -
FIG. 5 shows the details of the distal portion of the MHS, in accordance with a preferred embodiment of the present invention; -
FIGS. 6 a and 6 b show the flushing air device, in accordance with a preferred embodiment of the present invention, and -
FIG. 7 shows aconic mask 32, in accordance with a preferred embodiment of the present invention. - The following description is provided in order to enable any person skilled in the art to make use of the invention and sets forth the best modes contemplated by the inventor of carrying out this invention. Various modifications, however, will remain apparent to those skilled in the art, since the generic principles of the present invention have been defined specifically to provide a mask for analyzed mammals and methods using the same.
- The term ‘Magnetic Resonance Device’ (MRD) specifically applies hereinafter to any Magnetic Resonance Imaging (MRI) device, any Nuclear Magnetic Resonance (NMR) spectroscope, any Electron Spin Resonance (ESR) spectroscope, any Nuclear Quadruple Resonance (NQR) spectroscope or any combination thereof. The MRD hereby disclosed is optionally a portable MRI device, such as the ASPECT Magnet Technologies Ltd commercially available devices, or a commercially available non-portable device. Moreover, the term ‘MRD’ generally refers in this patent to any medical device, at least temporary accommodating an anesthetized animal.
- The term ‘about’ refers herein to a value of ±25% of the defined measure.
- Reference is now made to
FIG. 1 , schematically illustrating, not to scale, an MRI device, such as anMRD 10, comprising at least oneport 110. A mouse handling system (MHS, 100), which is a maneuverable elongated device, is inserted through theport 10. In preferred embodiments, theMHS 100 is characterized by a substantially circular cross-section and aproximal portion 20, which is located outside theMRD 10. TheMHS 100 further includes ashaft 21, and a distal portion 30 (seeFIG. 2 ). Themaneuverable MHS 100 is rotatable about longitudinal axis of the shaft 21 (FIGS. 1 and 2 ) and is translationally maneuverable parallel to theshaft 21. Theproximal end 20 is slideable over theshaft 21, providing a telescopic mechanism of variable length. - Reference is now made to
FIG. 2 , schematically illustrating, not to scale, theMHS 100 includes the flange 11 a and a flange 11 b, located at a distal opposite end of theMHS 100. The MHS 100 is inserted intoport 110 of theMRD 10. Theproximal portion 20 ofMHS 100 comprises a plurality of levers and handles (22 a and 22 b) which lock the location of themaneuverable MHS 100, within theMRD 10 and a connection mechanism adapted to communicate the encapsulated environment of thedistal portion 30 with theproximal portion 20, by means of a plurality of fluid-connecting pipes (not shown here). Theproximal end 20 ofMHS 100 comprises a plurality of indicia, such as arotation indication 23 b, positioned on theshaft 21 indicates the angular and translational relative position of theMHS 100 with respect toMRD 10. According to one embodiment of the invention, theproximal portion 20 of theMHS 100 includes anairtight capsule 30 comprising ashell 22, an animal bed orcradle 31, for locating an animal 1 to be studied as well as afluid supplying mechanism 33. The role ofshell 22, inter alia, is (i) to form an airtight capsule to prevent leakage of anesthetization gas from the gas supply inlets to the laboratory environment; (ii) to provide thermal isolation between the laboratory environment the air-conditioned environment surrounding the animal in theshell 22 and the laboratory environment; and (iii) to prevent accidental spillage of hazardous materials, e.g. radioactive agents outside theshell 22 surrounding the animal. - Reference is now made to
FIG. 3 , schematically illustrating, not to scale, theproximal portion 20 ofMHS 100, which comprises theshaft 21 upon which atranslational scale 22 a and arotation scale 23 b are positioned, and a distal portion 30 (here without shell 20), where mouse 1 is lying thereon thecradle 31. - Reference is now made to
FIG. 4 , schematically illustrating, not to scale, thedistal portion 30. The mouse 1 is immobilized on thecradle 31 and its head is placed within amask 32. The position of themask 32 within ahousing 33 is determined by means ofrotatable rod 34. - Reference is now made to
FIG. 5 , schematically illustrating, not to scale, thedistal portion 30. According to one embodiment of the invention, thecradle 31 comprises a heating/cooling mechanism 38.Mask 32 may comprisemouthpiece 35 andanesthetization gas outlet 35 a in fluid communication with anesthetization gas inlet 35 b.Mask 32 is located within a housing offluid supply mechanism 33, and its position is accurately determined byrod 34. - Anesthetization gas is supplied to the animal via
inlet 36 a with flow f (cm3/sec). Air suction is provided from themask 32 and apertures thereon (not shown) via inner portion of thehousing 33 tosuction outlet 37 with flow F, wherein F>>f. Hence, leakage of anesthetization gas fromoutlet 36 a and the inner portion ofcapsule 22 to the external environment of the laboratory is avoided. - Reference is now made to
FIGS. 6 a and 6 b, schematically illustrating, not to scale, the facilitated flow of flushing air device. The flow begins from the behindanesthetization gas inlet 36 a and passes around the animal's head viamask 32 and plurality ofapertures 32 a into the Bernoulli-type orifice 32 b (orifice 32 b is narrow relative to the widest diameter of the mask), via ahollow chamber 33 a of thehousing 33, to anoutlet 37 and to a gas scavenger located outside the MRD. - Reference is finally made to
FIG. 7 , schematically illustrating, not to scale, aconic mask 32 and its plurality ofapertures 32 a, a Bernoulli-type orifice 32 b (orifice 32 b is narrow relative to the widest diameter of mask), andadapter 32 c which couples themask 32 to thehousing 33 in a maneuverable manner. The role ofapertures 32 a located in the outer circumference of the mask is to ensure effective flushing of air due to the irregular geometry of the animal's head 1, and to avoid blocking of air suction by the animal's body parts and fur. - Examples of various features/aspects/components/operations have been provided to facilitate understanding of the disclosed embodiments of the present invention. In addition, various preferences have been discussed to facilitate understanding of the disclosed embodiments of the present invention. It is to be understood that all examples and preferences disclosed herein are intended to be non-limiting.
- Although selected embodiments of the present invention have been shown and described individually, it is to be understood that at least aspects of the described embodiments may be combined.
- Although selected embodiments of the present invention have been shown and described, it is to be understood the present invention is not limited to the described embodiments. Instead, it is to be appreciated that changes may be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and the equivalents thereof.
Claims (17)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/241,344 US8851018B2 (en) | 2010-09-27 | 2011-09-23 | Mask for analyzed mammals |
US14/478,562 US20140378821A1 (en) | 2010-09-27 | 2014-09-05 | Mask for analyzed mammals |
US14/478,575 US9820675B2 (en) | 2010-09-27 | 2014-09-05 | Mask for analyzed mammals |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38659510P | 2010-09-27 | 2010-09-27 | |
US13/241,344 US8851018B2 (en) | 2010-09-27 | 2011-09-23 | Mask for analyzed mammals |
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Also Published As
Publication number | Publication date |
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DE202011050130U1 (en) | 2011-08-01 |
US20140378825A1 (en) | 2014-12-25 |
US20140378821A1 (en) | 2014-12-25 |
US8851018B2 (en) | 2014-10-07 |
US9820675B2 (en) | 2017-11-21 |
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