US20120312779A1 - Methods for manufacturing implants having integration surfaces - Google Patents
Methods for manufacturing implants having integration surfaces Download PDFInfo
- Publication number
- US20120312779A1 US20120312779A1 US13/566,384 US201213566384A US2012312779A1 US 20120312779 A1 US20120312779 A1 US 20120312779A1 US 201213566384 A US201213566384 A US 201213566384A US 2012312779 A1 US2012312779 A1 US 2012312779A1
- Authority
- US
- United States
- Prior art keywords
- implant
- blank
- top surface
- interbody spinal
- spinal implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Images
Classifications
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Abstract
Description
- This application is a continuation-in-part of U.S. patent application Ser. No. 12/151,198, filed on May 5, 2008, and pending, which is a continuation-in-part of U.S. patent application Ser. No. 11/123,359, filed on May 6, 2005, and issued as U.S. Pat. No. 7,662,186. The contents of both prior applications are incorporated by reference into this document, in their entirety and for all purposes.
- The present invention relates generally to improved methods of making interbody spinal implants and, more particularly, to an optimized sequence of process steps necessary to faun spinal implants having integration surfaces of better quality with reduced process time and costs.
- In the simplest terms, the spine is a column made of vertebrae and discs. The vertebrae provide the support and structure of the spine while the spinal discs, located between the vertebrae, act as cushions or “shock absorbers.” These discs also contribute to the flexibility and motion of the spinal column. Over time, the discs may become diseased or infected, may develop deformities such as tears or cracks, or may simply lose structural integrity (e.g., the discs may bulge or flatten). Impaired discs can affect the anatomical functions of the vertebrae, due to the resultant lack of proper biomechanical support, and are often associated with chronic back pain.
- Several surgical techniques have been developed to address spinal defects, such as disc degeneration and deformity. Spinal fusion has become a recognized surgical procedure for mitigating back pain by restoring biomechanical and anatomical integrity to the spine. Spinal fusion techniques involve the removal, or partial removal, of at least one intervertebral disc and preparation of the disc space for receiving an implant by shaping the exposed vertebral endplates. An implant is then inserted between the opposing endplates.
- Spinal fusion procedures can be achieved using a posterior or an anterior approach, for example. Anterior interbody fusion procedures generally have the advantages of reduced operative times and reduced blood loss. Further, anterior procedures do not interfere with the posterior anatomic structure of the lumbar spine. Anterior procedures also minimize scarring within the spinal canal while still achieving improved fusion rates, which is advantageous from a structural and biomechanical perspective. These generally preferred anterior procedures are particularly advantageous in providing improved access to the disc space, and thus correspondingly better endplate preparation.
- There are a number of problems, however, with traditional spinal implants including, but not limited to, improper seating of the implant, implant subsidence (defined as sinking or settling) into the softer cancellous bone of the vertebral body, poor biomechanical integrity of the endplates, damaging critical bone structures during or after implantation, and the like. In summary, at least ten, separate challenges can be identified as inherent in traditional anterior spinal fusion devices. Such challenges include: (1) end-plate preparation; (2) implant difficulty; (3) materials of construction; (4) implant expulsion; (5) implant subsidence; (6) insufficient room for bone graft; (7) stress shielding; (8) lack of implant incorporation with vertebral bone; (9) limitations on radiographic visualization; and (10) cost of manufacture and inventory.
- With regard to manufacturing of such implants, there are traditionally many steps necessary to produce a high quality implant. For example, the method or process may require a series of steps including, but not necessarily limited to, cutting the basic implant shape from raw materials and then sequentially adding features by removing material from the initial basic shape. Thus, such methods may include numerous steps of holding and releasing the part until the finished implant is completed. In addition, the parts may undergo subsequent surface processing to provide surface enhancements on the completed implant. The location of such surface enhancements may be limited by the capabilities of the manufacturing process, the resulting surfaces may be non-uniform or inconsistent providing low yields, and the process may require hand processing or costly machining steps in order to provide high-quality implants meeting all required specifications.
- The present invention provides for interbody spinal implants produced by simplified and optimized methods, which allow each step to be utilized without constraining the subsequent processes or degrading the previous process steps. The process of the present invention can use the same raw materials as traditional implant manufacturing methods, but with fewer process steps and fewer transitions during the manufacturing process. The dimensions and surface features of the implant may be produced in a more accurate and repeatable fashion. In addition, the need for hand processing or special machining can be minimized or eliminated. For at least these reasons, the production time and costs may also be reduced in producing the implants.
- In one embodiment, the present invention provides a method of producing an interbody spinal implant including obtaining a blank (e.g., from a supplier or manufacturing the blank from raw materials) comprising a top surface, a bottom surface, opposing lateral sides, and opposing anterior and posterior portions, and applying a subtractive process, such as masked acid etching, to at least a portion the top surface, the bottom surface, or both surfaces of the blank to form a roughened surface topography. After the subtractive process, the blank is machined (e.g., milled, turned, or the like) to form an interbody spinal implant. The interbody spinal implant has a body with a top surface and a bottom surface, where the top surface, the bottom surface, or both surfaces of the interbody spinal implant have the roughened surface topography formed by the subtractive process. The implant also includes opposing lateral sides and opposing anterior and posterior portions—all formed from the blank. The implant is also machined to have a substantially hollow center, and a single vertical aperture (a) extending from the top surface to the bottom surface of the body, (b) having a size and shape predetermined to maximize the surface area of the top surface and the bottom surface available proximate the anterior and posterior portions while maximizing both radiographic visualization and access to the substantially hollow center, and (c) defining a transverse rim. The implant may be machined to have additional features, such as at least one transverse aperture, one or more holes, and the like.
- The roughened surface topography preferably includes a regular repeating pattern. The regular repeating pattern may help to promote bone growth, fusion, and healing responses and may be oriented in opposition to the biologic forces on the interbody spinal implant and to an insertion direction. The regular repeating pattern may be formed using mask techniques as the subtractive process. Therefore, the subtractive process may include applying a maskant (e.g., by sputtering, deposition, evaporation, or the like) to the top surface, bottom surface, or both surfaces of the blank. After the maskant is applied and cured, the subtractive process may include, for example, applying an acid etching solution (e.g., by spraying, immersion, or the like) to the unmasked surfaces. Once etched, a single time or repeatedly, the maskant may then be removed to reveal the roughened surface topography. The blank now having the roughened surface topography on the top, bottom, or both surfaces can then be machined into the appropriate implant shapes and including any apertures, holes, and the like.
- Various implant body shapes are provided to allow for implantation through various access paths to the spine through a patient's body. The structures and surfaces are designed to work in concert to preserve endplate bone structures, provide for sufficient bioactivity in each respective location, and provide stability within the disc space and the graft containment axial column. In particular, the shapes and textures of the bioactive surfaces vary based on the implant insertion path, location within the disc space, and frictional characteristics of the surfaces.
- The methods may also include other steps, such as machining the blank to have a slope or angle (e.g., a lordosis angle); cutting the blank to implant width before machining the blank to form the interbody spinal implant; and subjecting at least one surface of the interbody spinal implant, once formed, to nano processing (e.g., mild chemical etching, laser or other directed energy material removal, abrasion, blasting, tumbling, or the like).
- In another embodiment, a method of producing a composite interbody spinal implant includes obtaining a blank comprising a top surface, a bottom surface, opposing lateral sides, and opposing anterior and posterior portions; applying a subtractive process to at least a portion of the top surface of the blank to form a roughened surface topography; and subsequently machining the blank to form an integration plate. The integration plate has a top surface comprising an integration surface with the roughened surface topography, a bottom surface, opposing lateral sides, opposing anterior and posterior portions, and a single vertical aperture extending from the top surface to the bottom surface. One or two integration plates may be combined and assembled with a separate body to form a composite interbody spinal implant. The body has a top surface, a bottom surface, opposing lateral sides, opposing anterior and posterior portions, a substantially hollow center, and a single vertical aperture extending from the top surface to the bottom surface of the body. The integration plate(s) and the body are assembled to align the components. In particular, the single vertical aperture of the integration plate is aligned with the single vertical aperture of the body such that the integration plate does not extend beyond the outer circumference of the body.
- The implant body, the integration plate or plates, or both components may be fabricated from a metal. A preferred metal is titanium or a titanium alloy. In the case of a composite implant, the implant body may be fabricated from a metal or a non-metallic material.
- The resulting implant, for a solid body implant or a composite implant, comprises at least one integration surface having a roughened surface topography where the entire implant or the integration plate was produced by such a process that the surfaces and edges of the implant are of high quality and reliability. Thus, the resulting surfaces are uniform and consistent providing high yields, the locations of the surface enhancements are not limited and are not degraded by subsequent processing, and the process does not require hand processing or costly machining in order to meet all required specifications.
- The invention is best understood from the following detailed description when read in connection with the accompanying drawing. It is emphasized that, according to common practice, the various features of the drawing are not to scale. On the contrary, the dimensions of the various features are arbitrarily expanded or reduced for clarity. Included in the drawing are the following figures:
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FIG. 1 shows a process flowchart according to one embodiment of the invention; -
FIG. 2 shows a process flowchart according to one method of producing implants; -
FIGS. 3A and 3B show a blank in the form of a bar with a lordis angle implant height; -
FIGS. 4A and 4B show the resulting bar profile after etching and a residual handle formed from the un-etched surfaces; -
FIGS. 5A and 5B show the blank after etching where the blank is cut to implant width; -
FIG. 6 shows a perspective view of an embodiment of the interbody spinal implant after machining with the handle still attached; -
FIG. 7A shows a perspective view of an embodiment of the interbody spinal implant having a generally oval shape and roughened surface topography on the top surface; -
FIG. 7B shows a top view of the embodiment of the interbody spinal implant illustrated inFIG. 7A ; -
FIG. 8 shows an exploded view of a generally oval-shaped implant with an integration plate; -
FIG. 9 shows an anterior view of an embodiment of the interbody spinal implant having two integration plates, which sandwich the body of the implant; -
FIG. 10 shows an exploded view of a curved implant with an integration plate; -
FIG. 11 shows an exploded view of a posterior implant with an integration plate; -
FIG. 12 shows an exploded view of a lateral lumbar implant with an integration plate; -
FIG. 13 shows an exploded view of a generally oval-shaped anterior cervical implant with an integration plate; -
FIG. 14 shows a side view of one embodiment of an implant having a lordosis angle and a tail; -
FIG. 15 shows a side view of one embodiment of an implant having a convex top and bottom surface; -
FIG. 16 illustrates one set of process steps that can be used to form macro, micro, or nano processes; -
FIG. 17 graphically represents the average amplitude, Ra; -
FIG. 18 graphically represents the average peak-to-valley roughness, Rz; -
FIG. 19 graphically represents the maximum peak-to-valley height, Rmax; -
FIG. 20 graphically represents the total peak-to-valley of waviness profile; and -
FIG. 21 graphically represents the mean spacing, Sm. - The present invention provides for interbody spinal implants, including solid body implants and composite implants, produced by fewer process steps and fewer transitions during the manufacturing process. The dimensions and surface features of the implant may be produced in a very accurate and repeatable manner without bleeding (e.g., bleeding of the acid etchant) or poor quality at the edges or interfaces between areas with different surface features (e.g., roughened topography versus substantially smooth surfaces).
- Under common manufacturing techniques, an implant may be produced by machining the implant from a raw material and, after the implant is produced, applying any surface processing to the surfaces requiring such treatment. Referring to the drawing, in which like reference numbers refer to like elements throughout the various figures that comprise the drawing,
FIG. 2 depicts a process flowchart according to one method of producing implants. For example, the raw material may be obtained from a supplier, and machined into the basic implant shape with certain features (e.g., holes). After machining the implant, certain surface features may be applied to desired surfaces. For example,FIG. 2 shows a method where a mask is applied to protect the surfaces of the implant (i.e., a protective maskant). Those protected surfaces will not undergo any surface treatment. The protective mask may be applied to the entire implant (e.g., by immersion in the maskant). Then, a portion of the protective mask may be removed, often cut by hand, to expose the area of the implant which requires a special surface treatment. Once the given area is exposed and unmasked, another mask may be applied to the exposed surface, for example, in a desired pattern. The surface may then undergo a surface treatment, such as acid etching, to remove the base material. It is possible that the surface could undergo repeated etchings. Therefore, the protective maskant must survive and protect the protected surfaces from such treatments, even if repeated several times. Problems arise, however, because the maskant may not provide good protection especially for repeated treatments or may start to bleed the etchant at the edges where the unprotected areas adjoin the protective maskant portions. If the etchant bleeds under the protective maskant, the bleed may produce holes or defects in undesired areas rendering the entire part worthless. In addition, because the protective maskant covering the surface to be treated is often removed by hand, there is a high likelihood of variability and inconsistency in the etching results. - Accordingly, in one embodiment of the present invention, a method of producing an interbody spinal implant includes obtaining a blank, applying a subtractive process to form a roughened surface topography on a surface of the blank, and, after the subtractive process, machining the blank to form an interbody spinal implant.
FIG. 1 depicts an exemplary embodiment of a process flowchart according to the invention. First, a blank is obtained or created. Then, the surface features are applied to the desired surface. For example, the mask is applied in a desired pattern and then an acid etch is applied. The etchant may even be applied repeatedly without worry of harming the other implant surfaces. After the surface treatment is applied, then the blank is machined into individual implants. The machining reveals inner areas of the blank which were not exposed to the subtractive process (e.g., the lateral sides 30, theanterior portion 40, and the smooth rounded edge 7). Accordingly, there is no likelihood of bleed or other defects in those areas. There is also no need to apply a protective maskant over the entire implant surface or to use hand processing or special equipment to remove portions of a protective maskant. -
FIGS. 3A and 3B show an example of a blank 6. The blank 6 may obtained or supplied, for example, in a bar shape (e.g., a substantially rectangular shape). It should be understood, however, that any suitable shape for the blank 6 may be selected based on the ultimate implant shape desired. For example, the blank 6 may be obtained from a raw material or part supplier or may be machined into the desired shape. Also, the blank 6 may be obtained by manufacturing (e.g., machining) raw materials typically used to construct the implants in a traditional process, such as titanium bars. The blank 6 comprises atop surface 16, abottom surface 26, opposinglateral sides 36, and opposinganterior portions 46 andposterior portions 56, which may generally correspond with the positions of the resulting implant 1 orintegration plate 82 made from the blank 6. The blank 6 may be in the form of a bar with a length L which allows for production of more than one implant from asingle blank 6. - The blank 6 and the resulting implant 1 may also be produced in other suitable shapes. In particular, the
top surface 16, thebottom surface 26, or both surfaces of the blank 6 (and ultimately the implant 1) may include curvatures, convexities, slopes, angles, radii, or compound surfaces. For example, thetop surface 16 andbottom surface 26 of the blank 6 corresponding to thetop surface 10 andbottom surface 20 of the implant 1 may include a convex curve, a concave curve, an angle, a tail, or a compound surface containing one or more of these types of surfaces. - In an exemplary embodiment, the blank 6 is machined to have a lordosis angle A. As will be well recognized by one of ordinary skill in the art, lordosis is curvature of a portion of the lumbar or cervical vertebral column.
FIG. 3A shows the lordosis angle A of the blank 6 may be provided with respect to the height of the blank 6. For example, theanterior portion 46 of the blank 6 may have a higher height that theposterior portion 56, which provides a lordosis angle A. As much as fifteen degrees of lordosis (or more) may be built into the blank 6 (and ultimately the implant) to help restore cervical balance. For example, the lordosis angle A may be between about 1-15 degrees, about 3-7 degrees, or any other degree of lordosis as is needed. - As shown in
FIG. 14 , theimplant 101 may comprise atail 152 proximate theposterior portion 150, which is formed from a blank 6 (not shown) having a tail (e.g., proximate theposterior portion 56 of the blank 6). Thetail 152 is preferably greater in height than the shortest distance between thetop surface 110 and thebottom surface 120 of theimplant 101. In one embodiment, thetail 152 is equal to or greater in height than the remainder of theimplant 101.FIG. 14 also shows a compound surface having both a lordosis angle A (e.g., about a 4 degree lordosis angle A) and atail 152 on thetop surface 110 and thebottom surface 120 proximate theposterior portion 150 of theimplant 101. The compound surface is preferably obtained from a blank 6 (not shown) having both a lordosis angle A and a tail on thetop surface 16 and thebottom surface 26. Thetail 152 may function, for example, as an anti-expulsion feature once theimplant 101 is inserted into position. - In another embodiment, the blank 6 is machined to have a convex curve on the
top surface 16, thebottom surface 26, or both surfaces of the blank 6 (not shown).FIG. 15 depicts animplant 101 that may be obtained from such a blank 6 machined with convex curves where thetop surface 110 and thebottom surface 120 of theimplant 101 each have a convex curve. The convex curve has a maximum height C substantially at the center point of thetop surface 110 and thebottom surface 120. The maximum height C may provide for any desired degree of curvature. For example, the maximum height C may be about one mm as compared with theposterior portion 150. It is also contemplated that the maximum height C of the curve may be at any point, not necessarily the midpoint, along thetop surface 110 or thebottom surface 120 of theimplant 101. The implants depicted inFIGS. 14 and 15 may be particularly well suited for Posterior Lumbar Interbody Fusion (PLIF). - The blank 6 may be composed of any suitable material. In a preferred embodiment, the blank 6 is comprised of a metal. Suitable metals, such as titanium, aluminum, vanadium, tantalum, stainless steel, and alloys of those metals, may be selected by one of ordinary skill in the art. In a preferred embodiment, the metal is at least one of titanium, aluminum, and vanadium, without any coatings. In a more preferred embodiment, the blank 6 is comprised of titanium or a titanium alloy.
- A subtractive process is applied to at least one surface of the blank 6. As used in this document, “subtractive process” is intended to encompass any process which removes material from a surface of the blank 6. Suitable subtractive techniques may include for example, machining (e.g., machine tools, such as saws, lathes, milling machines, and drill presses, are used with a sharp cutting tool to physically remove material to achieve a desired geometry), unmasked or masked etching (e.g., portions of the surface are protected by a masking material which resists etching and an etching substance is applied to unmasked portions), and the like. The subtractive process may include a single subtractive step or multiple subtractive steps.
- The subtractive process may include a masking step before the subtractive step or steps. In other words, a mask may be applied to the desired surface, for example, to produce a pattern (e.g., dots, circles, squares, lines, or amorphous shapes) before implementing the subtractive technique. The maskant may be applied using any suitable techniques known in the art, such as deposition (e.g., sputter deposition, vacuum deposition, physical vapor deposition, chemical vapor deposition, and spin coating) and evaporation (e.g., electron beam evaporation, thermal evaporation, and plasma assisted thermal evaporation). The sputtering may include, for example, DC sputtering, DC magnetron sputtering, AC sputtering, pulse DC sputtering, RF sputtering, and the like. In an exemplary embodiment, a maskant is applied in a regular pattern using a sputtering technique, for example, using an ink jet printing apparatus. A suitable maskant (e.g., a polymeric maskant) may be selected by one of ordinary skill in the art depending on the subtractive process employed. The maskant may be cured, for example, at room temperature or under heating. Once the subtractive process is complete and the pattern has been formed and cut into the blank 6, the maskant or maskants may be removed using any suitable mechanisms (e.g., solvent removal).
- In an exemplary embodiment, the subtractive process is applied to at least one of the surfaces which will become the integration surfaces of the resulting implant 1. As used in this document, the integration surface is the surface at least partially in contact with the vertebral or bone structure. In particular, the subtractive process may be applied to the
top surface 16 of the blank 6, thebottom surface 26 of the blank 6, or both surfaces. - The subtractive process ultimately results in one or more integration surfaces on the implant 1 having predefined surface features that (a) engage the vertebral endplates with a friction fit and, following an endplate preserving surgical technique, (b) attain initial stabilization, and (c) benefit fusion. The composition of the endplate is a thin layer of notch-sensitive bone that is easily damaged by features (such as teeth) that protrude sharply from the surface of traditional implants. Avoiding such teeth and the attendant risk of damage, the roughened
surface topography 80 of the integration surface(s) does not have teeth or other sharp, potentially damaging structures; rather, the roughenedsurface topography 80 may have a pattern of repeating features of predetermined sizes, smooth shapes, and orientations. As used in this document, “predetermined” means determined beforehand, so that the predetermined characteristic must be determined, i.e., chosen or at least known, before use of the implant 1. - These designed surfaces are composed of various sizes of features that, at the microscopic level, interact with the tissues and stimulate their natural remodeling and growth. At a larger scale these features perform the function of generating non-stressful friction that, when combined with a surgical technique that retains the most rigid cortical bone structures in the disc space, allow for a friction fit that does not abrade, chip, perforate, or compromise the critical endplate structures. The features may be divided into three size scales: nano, micro, and macro. The overlapping of the three feature sizes can be achieved using manufacturing processes that are completed sequentially and, therefore, do not remove or degrade the previous method.
- The subtractive process may be applied to the entire surface or a portion thereof of the blank 6. As depicted in
FIGS. 4A and 4B , the subtractive process may be applied to the portion of the blank 6 which will be formed into the implant 1 orintegration plate 82. The subtractive process may be used over the entire blank 6 or any portion thereof because the implant 1 orintegration plate 82 will ultimately be machined from the blank 6 and the machining will reveal inner portions of the blank 6 not exposed to such subtractive techniques (e.g., a substantially smooth rounded edge 7). In other words, there is no concern about etching unmasked areas and no need to provide a protective mask to protect certain surfaces. From a process optimization standpoint, however, it may be preferable to only apply the subtractive process to the desired surfaces.FIG. 4B depicts a region on theposterior portion 56 of the blank 6 extending from onelateral side 36 to the other which is not subjected to the subtractive process. As shown inFIG. 4A , this may result in a profile where the blank 6 is etched to the implant finish height and an un-etched portion along theposterior portion 56 remains to function as ahandle 66 in the subsequent machining operations. The blank 6 may also comprise a finished trimmed edge which is very consistent and may ultimately function as theexpulsion edge 8 in the implant 1 once formed. - The subtractive process may include macro processing, micro processing, or both. The term “macro” typically means relatively large; for example, in the present application, dimensions measured in millimeters (mm). The term “micro” typically means one millionth (10−6); for example, in the present application, dimensions measured in microns (m) which correspond to 10−6 meters.
- The macro processing may include mechanical (e.g., machining though conventional processes) or chemical bulk removal, for example, to generate macro features. The macro features may be of any suitable shape, for example, roughly spherical in shape, without undercuts or protruding sharp edges. Other shapes are possible, such as ovals, polygons (including rectangles), and the like. These features may be at least partially overlapped with other surface features using either chemical or mechanical methods (e.g., AlO2 blasting) in predetermined patterns which do not result in undercuts or protruding sharp edges.
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FIG. 16 illustrates one set of process steps that can be used to form macro, micro, or nano processes. As illustrated, there may be some overlap in the processes that can be applied to form each of the three types of features (macro, micro, and nano). For example, acid etching can be used to form the macro features, then the same or a different acid etching process can be used to form the micro features. The features may be provided in a random design or a predetermined pattern (e.g., a repeating pattern). - The macro features are relatively large features (e.g., on the order of millimeters). The macro features may be formed from subtractive techniques (e.g., mechanical or chemical bulk removal, for example) or additive techniques (e.g., deposition). Preferably, the macro features are foimed by subtractive techniques, which remove at least portions of the surface (e.g., from the titanium material that was used to form the blank 6). Suitable subtractive techniques may include, for example, machining (e.g., machine tools, such as saws, lathes, milling machines, and drill presses, are used with a sharp cutting tool to physically remove material to achieve a desired geometry) or unmasked or masked etching (e.g., portions of the surface are protected by a masking material which resists etching and an etching substance is applied to unmasked portions). The patterns may be organized in regular repeating patterns and optionally overlapping each other.
- Depending on the surface structure desired, the micro surface features (e.g., on the order of micrometers) may be applied to all or a portion of the surface (for example, to the surface that will ultimately form the integration surface). The micro features may also be formed from subtractive techniques (e.g., mechanical or chemical bulk removal, for example) or additive techniques (e.g., deposition). Preferably, the micro features are also formed by subtractive techniques.
- In an exemplary embodiment, the micro features are cut by masked or unmasked etching, such as acid etching. For example, portions of the surface, optionally including portions of the surface exposed by the macro processing described, may be exposed to a chemical etching. The subtractive process may comprise a single step or multiple steps. For example, the subtractive process may include about two to four sequential steps of acid etching.
- In a preferred embodiment, the subtractive process comprises or consists of the micro process. Most preferably, the subtractive process includes acid etching, with a strong or weak acid, such as hydrochloric acid (HCl), hydroiodic acid (HI), hydrobromic acid (HBr), hydrofluoric (HF), perchloric acid (HClO4), nitric acid (HNO3), sulfuric acid (H2SO4), and the like. The etching process may be repeated a number of times as necessitated by the amount and nature of the irregularities required for any particular application. Control of the strength of the etchant material, the temperature at which the etching process takes place, and the time allotted for the etching process—all allow fine control over the resulting surface produced by the process. The number of repetitions of the etching process can also be used to control the surface features. For example, the micro features may be obtained via the repetitive masking and chemical or electrochemical milling processes described in U.S. Pat. No. 5,258,098; No. 5,507,815; No. 5,922,029; and No. 6,193,762, the contents of which are incorporated by reference into this document, in their entirety, and for all purposes.
- The acid solution may be applied to the surface (e.g., a treated surface) of the blank 6 using any suitable mechanism or techniques known in the art, for example, immersion, spraying, brushing, and the like. In an exemplary embodiment, the acid solution is applied to the surface by immersing the entire blank 6 in the solution. If desired, certain areas of the surface or the blank 6 may be masked. After the acid solution is applied, the acid solution may be removed, for example, by rinsing with water (e.g., deionized water). The treated surface or the entire blank 6 may be subsequently dried. The treated surface may be dried using any suitable mechanism or techniques known in the art, for example, by heating in an oven (e.g., a dry oven).
- By way of example, an etchant mixture of at least one of nitric acid and hydrofluoric acid may be repeatedly applied to a titanium surface to produce an average etch depth of about 0.53 mm. In another example, chemical modification of a titanium surface can be achieved using at least one of hydrofluoric acid, hydrochloric acid, and sulfuric acid. In a dual acid etching process, for example, the first exposure may be to hydrofluoric acid and the second may be to a hydrochloric acid and sulfuric acid mixture. Chemical acid etching alone may enhance osteointegration without adding particulate matter (e.g., hydroxyapatite) or embedding surface contaminants (e.g., grit particles).
- The micro features may also be cut by abrasive or grit blasting, for example, by applying a stream of abrasive material (such as alumina, sand, and the like) to the surface. The abrasive material may include inert and non-bioactive materials. Alternatively, the abrasive material may include those materials reactive with biological functions as part of healing and fusions. In an exemplary embodiment, the micro features are created, at least partially, with an aqueous hydrochloric acid etching step and optionally at least partially with an AlO2 blasting step. Patterns may be organized in regular repeating patterns and optionally overlapping each other.
- The subtractive process forms a roughened
surface topography 80. The shapes of the frictional surface protrusions of the roughenedsurface topography 80 are formed using processes and methods commonly applied to remove metal during fabrication of implantable devices such as chemical, electrical, electrochemical, plasma, or laser etching; cutting and removal processes; casting; forging; machining; drilling; grinding; shot peening; abrasive media blasting (such as sand or grit blasting); and combinations of these subtractive processes. Additive processes such as welding, thermal, coatings, sputtering, and optical melt additive processes may also be suitable. The resulting surfaces either can be random in the shape and location of the features or can have repeating patterns. This flexibility allows for the design and production of surfaces that resist motion induced by loading in specific directions that are beneficial to the installation process and resist the opposing forces that can be the result of biologic or patient activities such as standing, bending, or turning or as a result of other activities. The shapes of the surface features work to increase the surface contact area but do not result in undercuts that generate a cutting or aggressively abrasive action on the contacting bone surfaces. - After the subtractive process, the blank 6 is machined to form an interbody spinal implant 1 or a portion of the implant 1 (e.g., an integration plate 82).
FIG. 5A shows theimplant footprint 1 a to be machined from the etched bar. The features of the implant 1 or theintegration plate 82 may be machined using typical equipment and techniques known in the art (e.g., by milling, turning, combinations of the two, or the like). Prior to cutting or removing the features of the implant 1 (the apertures, holes, etc.), the length L of the blank 6 may first be cut down to implant width. As shown inFIG. 6 , the blank 6 may be manipulated using thehandle 66, which may be removed after the implant 1 is formed. Because the implant 1 is machined from the etched blank 6, there are no extra process steps necessary to mask or protect certain areas of the implant 1 for special surface treatment. Moreover, there are no bleed or unwanted surface defects because the roughenedsurface 80 already exists on the implant 1 and does not need to be applied later. -
FIG. 6 show a perspective view of a first embodiment of the interbody spinal implant 1 in process, andFIG. 7A show a perspective view of the resulting interbody spinal implant 1, which is especially well adapted for use in an Anterior Lumbar Interbody Fusion (ALIF) procedure. The interbody spinal implant 1 includes atop surface 10, abottom surface 20, opposinglateral sides 30, and opposinganterior portions 40 andposterior portions 50. The interbody spinal implant 1 may include implants made of a single piece of material or composite implants. - Interbody spinal implants 1 made of a single piece of material or solid-body implants do not include
integration plates 82. Thus, the entire implant 1 is machined directly from asingle blank 6. The integration surface may include thetop surface 10 of the implant 1, thebottom surface 20 of the implant 1, or both surfaces. The integration surfaces have a roughenedsurface topography 80, without sharp teeth that risk damage to bone structures, and were formed in the subtractive process described above. - Composite implants include at least a
body 2 and one or twointegration plates 82, which may be formed from the same or different materials. The one or twointegration plates 82 are machined directly from the blank 6 and thebody 2 may be machined separately. The integration surfaces have a roughenedsurface topography 80, without sharp teeth that risk damage to bone structures, and were formed in the subtractive process. As depicted inFIG. 8 , the implant 1 includes afirst integration plate 82 affixed to thetop surface 10 of thebody 2 and an optional second integration plate 82 (shown inFIG. 9 ) affixed to thebottom surface 20 of thebody 2. Thefirst integration plate 82 and optionalsecond integration plate 82 each have atop surface 81, abottom surface 83, opposing lateral sides, opposinganterior portion 41 andposterior portion 51, and a singlevertical aperture 61 extending from thetop surface 81 to thebottom surface 83 and aligning with the singlevertical aperture 60 of thebody 2. - When present, the
integration plates 82 comprise an integration surface (e.g., thetop surface 81 of the integration plate 82), which is adapted to grip bone through friction generated when the implant 1 is placed between two vertebrae and to inhibit migration of the implant 1 once implanted. The integration surfaces may also have a fusion and biologically active surface geometry. In other words, at least a portion of thetop surface 81 of the first integration plate 82 (e.g., a first integration surface) and optionally atop surface 81 of a second integration plate 82 (e.g., a second integration surface) has a roughenedsurface topography 80, without sharp teeth that risk damage to bone structures. The roughenedsurface topography 80 preferably includes micro features of a regular repeating pattern, formed during the subtractive process, which may promote biological and chemical attachment or fusion with the bone structure. - The
body 2 and at least oneintegration plate 82 are preferably compatibly shaped, such that the implant 1 having thebody 2 and integration plate(s) 82 joined together may have a generally oval shape, a generally rectangular shape, a generally curved shape, or any other shape described or exemplified in this specification. Thus, for example, thebody 2 and the integration plate(s) 82 may be generally oval-shaped in transverse cross-section. Thebody 2 and the integration plate(s) 82 may be generally rectangular-shaped in transverse cross-section. Thebody 2 and the integration plate(s) 82 may be generally curved-shaped in transverse cross-section. - The
body 2 and integration plate(s) 82 of the implant 1 may be the same material or may be different materials. Thebody 2 and the integration plate(s) 82 may be composed of a suitable biocompatible material. In an exemplary embodiment, thebody 2 and optional integration plate(s) 82 are foiined of metal, which may be coated or not coated. Suitable metals, such as titanium, aluminum, vanadium, tantalum, stainless steel, and alloys of the metals, may be selected by one of ordinary skill in the art. In a preferred embodiment, however, the metal is at least one of titanium, aluminum, and vanadium, without any coatings. In a more preferred embodiment, thebody 2 and optional integration plate(s) 82 are comprised of titanium or a titanium alloy. An oxide layer may naturally form on a titanium or titanium alloy. - Alternatively, the
body 2 may be composed of a non-metal biocompatible material. In one embodiment, thebody 2 of the implant 1 is formed of a plastic, polymeric, or composite material. For example, suitable polymers may comprise silicones, polyolefins, polyesters, polyethers, polystyrenes, polyurethanes, acrylates, and co-polymers and mixtures of the polymers. Certain embodiments of the present invention may be comprised of a biocompatible, polymeric matrix reinforced with bioactive fillers, fibers, or both. Certain embodiments of the present invention may be comprised of urethane dimethacrylate (DUDMA)/tri-ethylene glycol dimethacrylate (TEDGMA) blended resin and a plurality of fillers and fibers including bioactive fillers and E-glass fibers. In another embodiment, thebody 2 comprises polyetherether-ketone (PEEK), hedrocel, or ultra-high molecular weight polyethylene (UHMWPE). Hedrocel is a composite material composed of carbon and an inert metal, such as tantalum. UHMWPE, also known as high-modulus polyethylene (HMPE) or high-performance polyethylene (HPPE), is a subset of the thermoplastic polyethylene, with a high molecular weight, usually between 2 and 6 million. - Certain embodiments of the interbody spinal implant 1 are substantially hollow and have a generally oval-shaped transverse cross-sectional area. Substantially hollow, as used in this document, means at least about 33% of the interior volume of the interbody spinal implant 1 is vacant. Still further, the substantially hollow portion may be filled with cancellous autograft bone, allograft bone, demineralized bone matrix (DBM), porous synthetic bone graft substitute, bone morphogenic protein (BMP), or combinations of those materials.
- Certain embodiments of the present invention may be especially suited for placement between adjacent human vertebral bodies. The implants of the present invention may be used in procedures such as Anterior Lumbar Interbody Fusion (ALIF), Posterior Lumbar Interbody Fusion (PLIF), Transforaminal Lumbar Interbody Fusion (TLIF), and cervical fusion. Certain embodiments do not extend beyond the outer dimensions of the vertebral bodies.
- The ability to achieve spinal fusion is directly related to the available vascular contact area over which fusion is desired, the quality and quantity of the fusion mass, and the stability of the interbody spinal implant. Interbody spinal implants, as now taught, allow for improved seating over the apophyseal rim of the vertebral body. Still further, interbody spinal implants, as now taught, better utilize this vital surface area over which fusion may occur and may better bear the considerable biomechanical loads presented through the spinal column with minimal interference with other anatomical or neurological spinal structures. Even further, interbody spinal implants, according to certain aspects of the present invention, allow for improved visualization of implant seating and fusion assessment. Interbody spinal implants, as now taught, may also stimulate osteointegration (e.g., formation of a direct structural and functional interface between the artificial implant and living bone or soft tissue) with the surrounding living bone.
- It is generally believed that the surface of an implant determines its ultimate ability to integrate into the surrounding living bone. Without being limited by theory, it is hypothesized that the cumulative effects of at least implant composition, implant surface energy, and implant surface roughness play a major role in the biological response to, and osteointegration of, an implant device. Thus, implant fixation may depend, at least in part, on the stimulation and proliferation of bone modeling and forming cells, such as osteoclasts and osteoblasts and like-functioning cells upon the implant surface. Still further, it appears that these cells attach more readily to relatively rough surfaces rather than smooth surfaces. In this manner, a surface may be bioactive due to its ability to stimulate cellular attachment and osteointegration. The roughened
surface topography 80 described in this document may better promote the osteointegration of certain embodiments of the present invention. The roughenedsurface topography 80 may also better grip the vertebral endplate surfaces and inhibit implant migration upon placement and seating. - Although not necessary, one or more surfaces of the implant 1, including the previously roughened
surface topography 80, may undergo further processing after the implant 1 is formed. Depending on the surface structure desired, nano surface features (e.g., on the order of nanometers) may be applied to all or a portion of one or more surfaces of the implant 1. The term “nano” typically means one billionth (10−9); for example, in the present application, dimensions measured in nanometers (nm) which correspond to 10−9 meters. The nano features may also be formed from subtractive techniques (e.g., mechanical or chemical bulk removal, for example) or additive techniques (e.g., deposition). Preferably, the nano features are also formed by subtractive techniques. - In an exemplary embodiment, the nano features are cut by masked or unmasked etching (e.g., chemical etching). In an exemplary embodiment, the nano process also includes an acid etching, with a strong or weak acid, such as hydrochloric acid (HCl), hydroiodic acid (HI), hydrobromic acid (HBr), hydrofluoric (HF), perchloric acid (HClO4), nitric acid (HNO3), sulfuric acid (H2SO4), and the like. The acid etching process for the nano step is preferably less aggressive than the acid etching process in the micro step. In other words, a less acidic, milder, or more diluted acid may be selected. In an exemplary embodiment, the nano features are created, at least partially, with an aqueous hydrochloric acid etching step.
- It is contemplated that the nano features may also be created by the abrasive or grit blasting, for example, described for the micro processing step. Patterns may be organized in regular repeating patterns and optionally overlapping each other.
- The nano features may also be achieved by tumble finishing (e.g., tumbling) the part or the implant 1. Suitable equipment and techniques can be selected by one of ordinary skill in the art. For example, a barrel may be filled with the parts or implants and the barrel is then rotated. Thus, the parts or implants may be tumbled against themselves or with steel balls, shot, rounded-end pins, ballcones, or the like. The tumbling process may be wet (e.g., with a lubricant) or dry.
- As should be readily apparent to a skilled artisan, the process steps described in this document can be adjusted to create a mixture of depths, diameters, feature sizes, and other geometries suitable for a particular implant application. The orientation of the pattern of features can also be adjusted. Such flexibility is desirable, especially because the ultimate pattern of the surface topography desired (for example, the integration surface of the implant 1) may be oriented in opposition to the biologic forces on the implant 1 and to the insertion direction. In one particular embodiment, for example, the pattern of the roughened
surface topography 80 may be modeled after an S-shaped tire tread. It is also contemplated that the same or different process steps may be used to create each of the macro, micro, and nano features on each of the desired surfaces. - Several separate parameters can be used to characterize the roughness of an implant surface. Among those parameters are the average amplitude, Ra; the maximum peak-to-valley height, Rmax; and the mean spacing, Sm. Each of these three parameters, and others, are explained in detail below. Surface roughness may be measured using a laser profilometer or other standard instrumentation.
- In addition to the parameters Ra, Rmax, and Sm mentioned above, at least two other parameters can be used to characterize the roughness of an implant surface. In summary, the five parameters are: (1) average amplitude, Ra; (2) average peak-to-valley roughness, Rz; (3) maximum peak-to-valley height, Rmax; (4) total peak-to-valley of waviness profile, Wt; and (5) mean spacing, Sm. Each parameter is explained in detail as follows.
- 1. Average Amplitude Ra
- In practice, “Ra” is the most commonly used roughness parameter. It is the arithmetic average height. Mathematically, Ra is computed as the average distance between each roughness profile point and the mean line. In
FIG. 17 , the average amplitude is the average length of the arrows. - In mathematical terms, this process can be represented as
-
- 2. Average Peak-to-Valley Roughness Rz
- The average peak-to-valley roughness, Rz, is defined by the ISO and ASME 1995 and later. Rz is based on one peak and one valley per sampling length. The RzDIN value is based on the determination of the peak-to-valley distance in each sampling length. These individual peak-to-valley distances are averaged, resulting in the RzDIN value, as illustrated in
FIG. 18 . - 3. Maximum Peak-to-Valley Height Rmax
- The maximum peak-to-valley height, Rmax, is the maximum peak-to-valley distance in a single sampling length—as illustrated in
FIG. 19 . - 4. Total Peak-to-Valley of Waviness Profile Wt
- The total peak-to-valley of waviness profile (over the entire assessment length) is illustrated in
FIG. 20 . - 5. Mean Spacing Sm
- The mean spacing, Sm, is the average spacing between positive mean line crossings. The distance between each positive (upward) mean line crossing is determined and the average value is calculated, as illustrated in
FIG. 21 . - The parameters Sm, Rmax, and Ra can be used to define the surface roughness following formation of each of the three types of features: macro, micro, and nano.
- If present, the following preferred ranges (all measurements in microns) are as follows for the macro features for each of the three parameters. The mean spacing, Sm, is between about 400-2,000, with a range of 750-1,750 preferred and a range of 1,000-1,500 most preferred. The maximum peak-to-valley height, Rmax, is between about 40-500, with a range of 150-400 preferred and a range of 250-300 most preferred. The average amplitude, Ra, is between about 8-200, preferably, 20-200, more preferably 50-150, and most preferably 100-125.
- If present, the following preferred ranges (all measurements in microns) are as follows for the micro features for each of the three parameters. The mean spacing, Sm, is between about 20-400, with a range of 100-300 preferred and a range of 200-250 most preferred. The maximum peak-to-valley height, Rmax, is between about 2-40, with a range of 2-20 preferred and a range of 9-13 most preferred. The average amplitude, Ra, is between about 1-20, preferably 2-15, more preferably 4-10, even more preferably 2-8, and most preferably 2-6.
- If present, the following preferred ranges (all measurements in microns) are as follows for the nano features for each of the three parameters. The mean spacing, Sm, is between about 0.5-20, with a range of 1-15 preferred and a range of 5-12 most preferred. The maximum peak-to-valley height, Rmax, is between about 0.2-2, with a range of 0.2-1.8 preferred and a range of 0.3-1.3 most preferred. The average amplitude, Ra, is between about 0.01-2, preferably 0.01-1, more preferably, 0.02-0.8, and most preferably 0.03-0.6.
- An example of such data is provided in Table 2 below.
-
TABLE 2 EXAMPLE DATA BY PROCESS STEP Size (Sm) Depth (Rmax) Roughness (Ra) Surface Feature Size and Roughness (Metric): Macro (μm) Max. 2,000 500 200 Min. 400 40 20 Avg. 1,200 270 110 Surface Feature Size and Roughness (Metric): Micro (μm) Max. 400 40 20 Min. 20 2 1 Avg. 210 11 5.5 Surface Feature Size and Roughness (Metric): Nano (μm) Max. 20 2 1 Min. 0.5 0.2 0.01 Avg. 10.25 1.1 0.505 - In the case of a
composite implant FIGS. 8 and 9 ), 182 a (FIG. 10 ), 182 (FIG. 11 ), 382 (FIG. 12 ), and 282 (FIG. 13 ), respectively, includes the roughenedsurface topography top surface bottom surface integration plate top surface bottom surface anterior portion posterior portion vertical aperture anterior portion anterior portion main body 2 of theimplant posterior portion posterior portion main body 2 of theimplant vertical aperture vertical aperture main body 2 of theimplant vertical aperture vertical aperture - The
integration plate implant bottom surface integration plate posts holes top surface bottom surface main body 2 of theimplant integration plate main body 2 of theimplant integration plates implant implant anti-expulsion edges - The
implant integration plate top surface bottom surface implant holes posts bottom surface integration plate posts holes -
FIG. 8 shows that thetop surface 10 is recessed and comprises a plurality of holes 12, but the recessedbottom surface 20 and its holes 12 are not shown.FIG. 10 shows that thetop surface 110 a is recessed and comprises a plurality ofholes 112 a, but the recessedbottom surface 120 a and itsholes 112 a are not shown.FIG. 11 shows that thetop surface 110 is recessed and comprises a plurality ofholes 112, but the recessedbottom surface 120 and itsholes 112 are not shown.FIG. 12 shows that thetop surface 310 is recessed and comprises a plurality ofholes 312, but the recessedbottom surface 320 and itsholes 312 are not shown.FIG. 13 shows that thetop surface 210 is recessed and comprises a plurality ofholes 212, but the recessedbottom surface 220 and itsholes 212 are not shown. The recess may be at a depth D, and the recess depth D preferably is uniform throughout thetop surface bottom surface - The recess depth D preferably corresponds to a thickness T of the
integration plate integration plate implant top surface bottom surface implant integration plate top surface bottom surface posterior portion anterior portion integration plate anterior portion posterior portion - The recess depth D and the thickness T may each independently be from about 0.1 mm to about 10 mm. In preferred aspects, the recess depth D and the thickness T may each independently be from about 1 mm to about 5 mm. Thus, for example, the recess depth D or the thickness T may be selected from about 0.1 mm, about 0.25 mm, about 0.5 mm, about 0.75 mm, about 1 mm, about 1.25 mm, about 1.5 mm, about 1.75 mm, about 2 mm, about 2.25 mm, about 2.5 mm, about 2.75 mm, about 3 mm, about 3.25 mm, about 3.5 mm, about 3.75 mm, about 4 mm, about 4.25 mm, about 4.5 mm, about 4.75 mm, about 5 mm, 5.5 mm, about 6 mm, about 6.5 mm, about 7 mm, about 75 mm, or about 8 mm.
- Recessing the
top surface bottom surface ridge anterior portion posterior portion integration plate implant - The
integration plate implant 101, integration plate 182), or TLIF fusion (e.g., implant 101 a,integration plate 182 a); may be used with an implant suitable for cervical fusion (e.g.,implant 201, integration plate 282); and may be used with an implant suitable for lateral lumbar insertion (e.g.,implant 301, integration plate 382). - The reciprocal connector such as the
post hole integration plate implant post hole post hole integration plate implant - The structures and features may be on either or both of the
integration plate main body 2 of theimplant integration plate implant - The
integration plate implant implant implant integration plate integration plate implant body 2 of theimplant hole - It is also contemplated that the
bottom surface integration plate implant bottom surface body 2 of theimplant - An adhesive (not shown) may directly join the
integration plate body 2 of theimplant bottom surface integration plate top surface bottom surface implant - The foregoing describes various non-limiting examples of how the one or two
integration plates implant - The implant 1 may be machined to comprise some or all of the following implant features, for example. In some aspects, the interbody spinal implant 1 is substantially hollow and has a generally oval-shaped transverse cross-sectional area with smooth, rounded, or both smooth and rounded
lateral sides 30 and posterior-lateral corners. The implant 1 includes at least onevertical aperture 60 that extends the entire height of theimplant body 2. Thevertical aperture 60 defines an interior surface or hollow cavity within the implant 1, which may be filled with bone growth inducing materials. The vertical aperture (a) extends from the top surface to the bottom surface, (b) has a size and shape predetermined to maximize the surface area of the top surface and the bottom surface available proximate the anterior and posterior portions while maximizing both radiographic visualization and access to the substantially hollow center, and (c) optionally defines a transverse rim. Thevertical aperture 60 may further define atransverse rim 100 having a greaterposterior portion thickness 55 than ananterior portion thickness 45. - In at least one embodiment, the opposing
lateral sides 30 and theanterior portion 40 have arim thickness 45 of about 5 mm, while theposterior portion 50 has arim thickness 55 of about 7 mm. Thus, the rimposterior portion thickness 55 may allow for better stress sharing between the implant 1 and the adjacent vertebral endplates and helps to compensate for the weaker posterior endplate bone. In some aspects, thetransverse rim 100 has a generally large surface area and contacts the vertebral endplate. Thetransverse rim 100 may act to better distribute contact stresses upon the implant 1, and hence minimize the risk of subsidence while maximizing contact with the apophyseal supportive bone. It is also possible for thetransverse rim 100 to have a substantially constant thickness (e.g., for theanterior portion thickness 45 to be substantially the same as the posterior portion thickness 55) or for theposterior portion 50 to have arim thickness 55 less than that of the opposinglateral sides 30 and theanterior portion 40. - The implant 1 may be shaped to reduce the risk of subsidence, and improve stability, by maximizing contact with the apophyseal rim of vertebral endplates. Embodiments may be provided in a variety of anatomical footprints having a medial-lateral width ranging from about 32 mm to about 44 mm. An interbody spinal implant 1 generally does not require extensive supplemental or obstructive implant instrumentation to maintain the prepared disc space during implantation. Thus, the interbody spinal implant 1 and associated implantation methods allow for larger-sized implants as compared with other size-limited interbody spinal implants known in the art. This advantage allows for greater medial-lateral width and correspondingly greater contact with the apophyseal rim.
- As illustrated in
FIG. 7A andFIG. 8 , the implant 1 has anopening 90 in theanterior portion 40. In one embodiment, theposterior portion 50 may have a similarly shaped opening 90 (not shown). In some aspects, only theanterior portion 40 has theopening 90 while theposterior portion 50 has an alternative opening 92 (which may have a size and shape different from the opening 90). Theopening 92 defines an interior surface 92 a or hollow cavity, which may be filled with bone growth inducing materials. - The
opening implant opening opening implant opening - As best shown in
FIGS. 10 and 11 , theanterior portion nose implant 101. - The implant 1 may further include at least one
transverse aperture 70 that extends the entire transverse length of the implant body. Thetransverse aperture 70 defines an interior surface or hollow cavity, which may be filled with bone growth inducing materials. The at least onetransverse aperture 70 may provide improved visibility of the implant 1 during surgical procedures to ensure proper implant placement and seating, and may also improve post-operative assessment of implant fusion. Thetransverse aperture 70 may be broken into two, separate sections by an intermediate wall. Suitable shapes and dimensions for thetransverse aperture 70 may be selected by one of ordinary skill in the art. In particular, all edges of thetransverse aperture 70 may be rounded, smooth, or both. The intermediate wall may be made of the same material as the remainder of thebody 2 of the implant 1 (e.g., plastic), or it may be made of another material (e.g., metal). The intermediate wall may offer one or more of several advantages, including reinforcement of the implant 1 and improved bone graft containment. - The implant 1 may be provided with a solid rear wall (not shown). The rear wall may extend the entire width of the implant body and nearly the entire height of the implant body. Thus, the rear wall can essentially close the
anterior portion 40 of the implant 1. The rear wall may offer one or more of several advantages, including reinforcement of the implant 1 and improved bone graft containment. In the cervical application, it may be important to prevent bone graft material from entering the spinal canal. - The implant 1 may also have a lordotic angle to facilitate alignment. The
anterior portion 40 is preferably generally greater in height than the opposingposterior portion 50. Therefore, the implant 1 may better compensate for the generally less supportive bone found in certain regions of the vertebral endplate. As much as seven degrees of lordosis (or more) may be built into the implant 1 to help restore cervical balance. - To enhance movement resistance and provide additional stability under spinal loads in the body, the
implant anti-expulsion edges top surface 81 of theintegration plate 82 affixed to thetop surface bottom surface implant anti-expulsion edges top surface bottom surface body 2 of theimplant anti-expulsion edges - By way of example,
FIG. 8 shows ananti-expulsion edge 8 on thetop surface 81 of theintegration plate 82 and thebottom surface 20 of theanterior face 40 of the implant 1. Eachanti-expulsion edge 8 may protrude above the plane of thetop surface 81 of theintegration plate 82 andbottom surface 20, with the amount of protrusion increasing toward theanterior face 40 and the highest protrusion height P at the anterior-most edge of thetop surface 81 of theintegration plate 82 orbottom surface 20. - An
anti-expulsion edge anterior portion posterior portion lateral sides anti-expulsion edge implant - Example Surgical Methods
- The following examples of surgical methods are included to more clearly demonstrate the overall nature of the invention. These examples are exemplary, not restrictive, of the invention.
- Certain embodiments of the invention are particularly suited for use during interbody spinal implant procedures currently known in the art. For example, the disc space may be accessed using a standard mini open retroperitoneal laparotomy approach. The center of the disc space is located by AP fluoroscopy taking care to make sure the pedicles are equidistant from the spinous process. The disc space is then incised by making a window in the annulus for insertion of certain embodiments of the
spinal implant - Use of a rasp preferably substantially minimizes or eliminates removal of bone, thus substantially minimizing or eliminating impact to the natural anatomical arch, or concavity, of the vertebral endplate while preserving much of the apophyseal rim. Preservation of the anatomical concavity is particularly advantageous in maintaining biomechanical integrity of the spine. For example, in a healthy spine, the transfer of compressive loads from the vertebrae to the spinal disc is achieved via hoop stresses acting upon the natural arch of the endplate. The distribution of forces, and resultant hoop stress, along the natural arch allows the relatively thin shell of subchondral bone to transfer large amounts of load.
- During traditional fusion procedures, the vertebral endplate natural arch may be significantly removed due to excessive surface preparation for implant placement and seating. This is especially common where the
implant implant implant - Preferred embodiments of the surgical method minimize endplate bone removal on the whole, while still allowing for some removal along the vertebral endplate far lateral edges where the subchondral bone is thickest. Still further, certain embodiments of the interbody
spinal implant surgical implant - Because the endplates are spared during the process of inserting the
spinal implant spinal implant - Interbody
spinal implant topography 80 may lessen the risk of excessive bone removal during distraction as compared to implants having teeth, ridges, or threads currently known in the art even in view of a press-fit surgical distraction method. Nonetheless, once implanted, the interbodysurgical implant spinal implant - Surgical implants and methods according to embodiments of the invention tension the vertebral annulus via distraction. These embodiments may also restore spinal lordosis, thus improving sagittal and coronal alignment. Implant systems currently known in the art require additional instrumentation, such as distraction plugs, to tension the annulus. These distraction plugs require further tertiary instrumentation, however, to maintain the lordotic correction during actual spinal implant insertion. If tertiary instrumentation is not used, then some amount of lordotic correction may be lost upon distraction plug removal. Interbody
spinal implant - Certain embodiments of the
spinal implant spinal implant - Certain embodiments collectively comprise a family of implants, each having a common design philosophy. These
implants - After desired annulotomy and discectomy, embodiments of the invention first adequately distract the disc space by inserting (through impaction) and removing sequentially larger sizes of very smooth distractors, which have been size matched with the size of the
available implant implant implant implant - The implant geometry has features which allow it to be implanted via any one of an anterior, antero-lateral, or lateral approach, providing tremendous intra-operative flexibility of options. The
implant implant implant - The invention encompasses a number of
different implant composite implant surface topography 80 to allow for bony in-growth over time, and to provide resistance against expulsion. The top and bottom titanium plates may be assembled together with theimplant body 2. The net result is acomposite implant - It is believed that an intact vertebral end-plate deflects like a diaphragm under axial compressive loads generated due to physiologic activities. If a
spinal fusion implant implant implant - Although illustrated and described above with reference to certain specific embodiments and examples, the present invention is nevertheless not intended to be limited to the details shown. Rather, various modifications may be made in the details within the scope and range of equivalents of the claims and without departing from the spirit of the invention. It is expressly intended, for example, that all ranges broadly recited in this document include within their scope all narrower ranges which fall within the broader ranges. In addition, features of one embodiment may be incorporated into another embodiment.
Claims (20)
Priority Applications (2)
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US13/566,384 US20120312779A1 (en) | 2005-05-06 | 2012-08-03 | Methods for manufacturing implants having integration surfaces |
US14/934,675 US9655745B2 (en) | 2005-05-06 | 2015-11-06 | Methods for manufacturing implants having integration surfaces |
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US11/123,359 US7662186B2 (en) | 2005-05-06 | 2005-05-06 | Anterior interbody spinal implant |
US12/151,198 US8262737B2 (en) | 2005-05-06 | 2008-05-05 | Composite interbody spinal implant having openings of predetermined size and shape |
US13/566,384 US20120312779A1 (en) | 2005-05-06 | 2012-08-03 | Methods for manufacturing implants having integration surfaces |
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US10603093B2 (en) | 2015-12-01 | 2020-03-31 | Industrial Technology Research Institute | Bone implant and manufacturing method thereof |
US10603182B2 (en) | 2015-01-14 | 2020-03-31 | Stryker European Holdings I, Llc | Spinal implant with fluid delivery capabilities |
US10729557B2 (en) * | 2018-08-21 | 2020-08-04 | Warsaw Orthopedic, Inc. | Porous surgical implant and method of making same |
US10821000B2 (en) | 2016-08-03 | 2020-11-03 | Titan Spine, Inc. | Titanium implant surfaces free from alpha case and with enhanced osteoinduction |
US11065126B2 (en) | 2018-08-09 | 2021-07-20 | Stryker European Operations Holdings Llc | Interbody implants and optimization features thereof |
US11096796B2 (en) | 2005-05-06 | 2021-08-24 | Titan Spine, Llc | Interbody spinal implant having a roughened surface topography on one or more internal surfaces |
CN113618234A (en) * | 2021-07-21 | 2021-11-09 | 丹源医学科技(杭州)有限公司 | Surface roughening method of thin-wall metal shell implanted into human body |
US11253368B2 (en) | 2017-02-14 | 2022-02-22 | Nanohive Medical Llc | Methods of designing high x-ray lucency lattice structures |
US11291558B2 (en) | 2018-07-26 | 2022-04-05 | Nanohive Medical Llc | Dynamic implant fixation plate |
US11370025B2 (en) | 2015-11-20 | 2022-06-28 | Titan Spine, Inc. | Processes for additively manufacturing orthopedic implants followed by eroding |
US11497617B2 (en) | 2019-01-16 | 2022-11-15 | Nanohive Medical Llc | Variable depth implants |
US11510786B2 (en) | 2014-06-17 | 2022-11-29 | Titan Spine, Inc. | Corpectomy implants with roughened bioactive lateral surfaces |
US11648124B2 (en) | 2017-04-01 | 2023-05-16 | Nanohive Medical Llc | Methods of designing three-dimensional lattice structures for implants |
US11918478B2 (en) * | 2018-12-05 | 2024-03-05 | Smed-Ta/Td, Llc | Adjusted stiffness orthopaedic implants and method of manufacture |
US11931266B2 (en) | 2016-06-07 | 2024-03-19 | Nanohive Medical Llc | Implant with independent endplates |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11801144B2 (en) * | 2017-09-14 | 2023-10-31 | Degen Medical, Inc. | Methods of making medical devices |
US10736752B1 (en) | 2017-10-24 | 2020-08-11 | Omnia Medical, LLC | Multi-material multi-component spinal implant |
US11766339B1 (en) | 2017-10-24 | 2023-09-26 | Omnia Medical, LLC | Multi-material multi-component spinal implant |
US11857436B1 (en) | 2019-07-31 | 2024-01-02 | Zavation Medical Products, Llc | Porous spinal implant |
US11051953B2 (en) | 2019-07-31 | 2021-07-06 | Zavation Medical Products, Llc | Porous spinal implant |
KR102574400B1 (en) * | 2021-06-21 | 2023-09-06 | 주식회사 씨에스와이 | Etching method and apparatus of dental implant fixture |
TWI820827B (en) * | 2022-07-27 | 2023-11-01 | 明志科技大學 | Surface treated intervertebral cage |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258098A (en) * | 1991-06-17 | 1993-11-02 | Cycam, Inc. | Method of production of a surface adapted to promote adhesion |
US5766252A (en) * | 1995-01-24 | 1998-06-16 | Osteonics Corp. | Interbody spinal prosthetic implant and method |
US5888224A (en) * | 1993-09-21 | 1999-03-30 | Synthesis (U.S.A.) | Implant for intervertebral space |
US6168631B1 (en) * | 1997-08-29 | 2001-01-02 | Kinetikos Medical, Inc. | Subtalar implant system and method for insertion and removal |
US20010001315A1 (en) * | 1998-04-23 | 2001-05-17 | Bates James S. | Atraumatic medical retrieval device |
US20020138143A1 (en) * | 1997-08-27 | 2002-09-26 | Grooms Jamie M. | Cortical bone cervical Smith-Robinson fusion implant |
US20030031984A1 (en) * | 1999-08-26 | 2003-02-13 | Richard P. Rusin | Ceramic dental mill blanks |
US20030065401A1 (en) * | 2001-01-25 | 2003-04-03 | Mark Amrich | Textured surface having undercut micro recesses in a surface |
US20050221258A1 (en) * | 2001-07-04 | 2005-10-06 | Nobel Biocare Ab | Implant for example dental implant |
US20080262623A1 (en) * | 2005-05-06 | 2008-10-23 | Titan Spine, Llc | Composite interbody spinal implant having openings of predetermined size and shape |
US20090312842A1 (en) * | 2008-06-16 | 2009-12-17 | Predrag Bursac | Assembled Cartilage Repair Graft |
Family Cites Families (196)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314876A (en) | 1980-03-17 | 1982-02-09 | The Diversey Corporation | Titanium etching solution |
GB8718627D0 (en) | 1987-08-06 | 1987-09-09 | Showell A W Sugicraft Ltd | Spinal implants |
US6923810B1 (en) | 1988-06-13 | 2005-08-02 | Gary Karlin Michelson | Frusto-conical interbody spinal fusion implants |
US5015247A (en) | 1988-06-13 | 1991-05-14 | Michelson Gary K | Threaded spinal implant |
US7452359B1 (en) | 1988-06-13 | 2008-11-18 | Warsaw Orthopedic, Inc. | Apparatus for inserting spinal implants |
US6123705A (en) | 1988-06-13 | 2000-09-26 | Sdgi Holdings, Inc. | Interbody spinal fusion implants |
CA1333209C (en) | 1988-06-28 | 1994-11-29 | Gary Karlin Michelson | Artificial spinal fusion implants |
US5609635A (en) | 1988-06-28 | 1997-03-11 | Michelson; Gary K. | Lordotic interbody spinal fusion implants |
CA1318469C (en) | 1989-02-15 | 1993-06-01 | Acromed Corporation | Artificial disc |
EP0388576B1 (en) | 1989-03-23 | 1993-09-15 | Institut Straumann Ag | Metallic implant |
US5306309A (en) | 1992-05-04 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant and implantation kit |
DE9216092U1 (en) | 1992-11-26 | 1993-01-14 | S + G Implants Gmbh, 2400 Luebeck, De | |
NO924697D0 (en) | 1992-12-04 | 1992-12-04 | Jan Erik Ellingsen | SURGICAL IMPLANT AND A PROCEDURE FOR TREATMENT OF SURGICAL IMPLANT |
US5584831A (en) | 1993-07-09 | 1996-12-17 | September 28, Inc. | Spinal fixation device and method |
US5425772A (en) | 1993-09-20 | 1995-06-20 | Brantigan; John W. | Prosthetic implant for intervertebral spinal fusion |
US5443514A (en) | 1993-10-01 | 1995-08-22 | Acromed Corporation | Method for using spinal implants |
US20010039454A1 (en) | 1993-11-02 | 2001-11-08 | John Ricci | Orthopedic implants having ordered microgeometric surface patterns |
US7048870B1 (en) | 1993-12-20 | 2006-05-23 | Astrazeneca Ab | Metallic implant and process for treating a metallic implant |
CA2551185C (en) | 1994-03-28 | 2007-10-30 | Sdgi Holdings, Inc. | Apparatus and method for anterior spinal stabilization |
JPH0810276A (en) | 1994-06-28 | 1996-01-16 | Nippon Electric Glass Co Ltd | Vertebra prosthetic material |
US6344057B1 (en) | 1994-11-22 | 2002-02-05 | Sdgi Holdings, Inc. | Adjustable vertebral body replacement |
US5863201A (en) | 1994-11-30 | 1999-01-26 | Implant Innovations, Inc. | Infection-blocking dental implant |
KR100402637B1 (en) | 1994-11-30 | 2004-04-03 | 임플랜트 이노베이션즈, 인코오포레이티드 | How to Make an Implant Surface |
US6491723B1 (en) | 1996-02-27 | 2002-12-10 | Implant Innovations, Inc. | Implant surface preparation method |
US6652765B1 (en) | 1994-11-30 | 2003-11-25 | Implant Innovations, Inc. | Implant surface preparation |
DE19504867C1 (en) | 1995-02-14 | 1996-02-29 | Harms Juergen | Position retainer for spine |
US6758849B1 (en) | 1995-02-17 | 2004-07-06 | Sdgi Holdings, Inc. | Interbody spinal fusion implants |
US5860973A (en) | 1995-02-27 | 1999-01-19 | Michelson; Gary Karlin | Translateral spinal implant |
WO1996027348A1 (en) | 1995-03-08 | 1996-09-12 | Synthes Ag, Chur | Intervertebral implant |
US5782919A (en) | 1995-03-27 | 1998-07-21 | Sdgi Holdings, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
US6039762A (en) | 1995-06-07 | 2000-03-21 | Sdgi Holdings, Inc. | Reinforced bone graft substitutes |
US5702449A (en) | 1995-06-07 | 1997-12-30 | Danek Medical, Inc. | Reinforced porous spinal implants |
DE19529605C2 (en) | 1995-08-11 | 1997-10-09 | Bernhard Zientek | Intervertebral implant |
US6423095B1 (en) | 1995-10-16 | 2002-07-23 | Sdgi Holdings, Inc. | Intervertebral spacers |
US5782830A (en) | 1995-10-16 | 1998-07-21 | Sdgi Holdings, Inc. | Implant insertion device |
DE19541114A1 (en) | 1995-10-26 | 1997-04-30 | Artos Med Produkte | Intervertebral implant |
US6033582A (en) | 1996-01-22 | 2000-03-07 | Etex Corporation | Surface modification of medical implants |
US5865845A (en) | 1996-03-05 | 1999-02-02 | Thalgott; John S. | Prosthetic intervertebral disc |
US5968098A (en) | 1996-10-22 | 1999-10-19 | Surgical Dynamics, Inc. | Apparatus for fusing adjacent bone structures |
US6241771B1 (en) | 1997-08-13 | 2001-06-05 | Cambridge Scientific, Inc. | Resorbable interbody spinal fusion devices |
FR2767675B1 (en) | 1997-08-26 | 1999-12-03 | Materiel Orthopedique En Abreg | INTERSOMATIC IMPLANT AND ANCILLARY OF PREPARATION SUITABLE FOR ALLOWING ITS POSITION |
DE29720022U1 (en) | 1997-11-12 | 1998-01-15 | Schaefer Micomed Gmbh | Intervertebral implant |
US6086613A (en) | 1997-12-23 | 2000-07-11 | Depuy Acromed, Inc. | Spacer assembly for use in spinal surgeries |
US6482233B1 (en) | 1998-01-29 | 2002-11-19 | Synthes(U.S.A.) | Prosthetic interbody spacer |
DE19807236C2 (en) | 1998-02-20 | 2000-06-21 | Biedermann Motech Gmbh | Intervertebral implant |
US6296664B1 (en) | 1998-06-17 | 2001-10-02 | Surgical Dynamics, Inc. | Artificial intervertebral disc |
US5885079A (en) | 1998-06-22 | 1999-03-23 | Core-Vent Corporation | Selective surface, endosseous dental implants |
GB2338652A (en) | 1998-06-23 | 1999-12-29 | Biomet Merck Ltd | Vertebral body replacement |
WO2000007527A1 (en) | 1998-08-03 | 2000-02-17 | Synthes Ag Chur | Intervertebral allograft spacer |
US6193757B1 (en) | 1998-10-29 | 2001-02-27 | Sdgi Holdings, Inc. | Expandable intervertebral spacers |
EP1023910A1 (en) | 1999-01-29 | 2000-08-02 | Institut Straumann AG | Preparation of osteophilic surfaces for metallic prosthetic devices anchorable to bone |
US6929662B1 (en) | 1999-02-04 | 2005-08-16 | Synthes (Usa) | End member for a bone fusion implant |
US6245108B1 (en) | 1999-02-25 | 2001-06-12 | Spineco | Spinal fusion implant |
US6241770B1 (en) | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
AU4246000A (en) | 1999-04-16 | 2000-11-02 | Nuvasive, Inc. | Articulation systems for positioning minimally invasive surgical tools |
US6342074B1 (en) | 1999-04-30 | 2002-01-29 | Nathan S. Simpson | Anterior lumbar interbody fusion implant and method for fusing adjacent vertebrae |
WO2000066044A1 (en) | 1999-05-05 | 2000-11-09 | Michelson Gary K | Nested interbody spinal fusion implants |
JP2003501142A (en) | 1999-06-04 | 2003-01-14 | エスディージーアイ・ホールディングス・インコーポレーテッド | Artificial implant for intervertebral disc |
WO2002009626A1 (en) | 1999-07-26 | 2002-02-07 | Advanced Prosthetic Technologies, Inc. | Improved spinal surgical prosthesis |
US6080158A (en) | 1999-08-23 | 2000-06-27 | Lin; Chih-I | Intervertebral fusion device |
WO2001028469A2 (en) | 1999-10-21 | 2001-04-26 | Sdgi Holdings, Inc. | Devices and techniques for a posterior lateral disc space approach |
US6830570B1 (en) | 1999-10-21 | 2004-12-14 | Sdgi Holdings, Inc. | Devices and techniques for a posterior lateral disc space approach |
US6592624B1 (en) | 1999-11-24 | 2003-07-15 | Depuy Acromed, Inc. | Prosthetic implant element |
US7115143B1 (en) | 1999-12-08 | 2006-10-03 | Sdgi Holdings, Inc. | Orthopedic implant surface configuration |
US6827740B1 (en) | 1999-12-08 | 2004-12-07 | Gary K. Michelson | Spinal implant surface configuration |
TW447286U (en) | 1999-12-10 | 2001-07-21 | Lin Jr Yi | Intervertebral restorer |
JP2001170092A (en) | 1999-12-21 | 2001-06-26 | Nippon Electric Glass Co Ltd | Vertebral arch spacer for enlarging operation of vertebral canal |
US6096107A (en) | 2000-01-03 | 2000-08-01 | Norton Company | Superabrasive products |
US7169183B2 (en) | 2000-03-14 | 2007-01-30 | Warsaw Orthopedic, Inc. | Vertebral implant for promoting arthrodesis of the spine |
JP2003527196A (en) | 2000-03-22 | 2003-09-16 | スコリオ ゲーエムベーハー | Cage-type intervertebral implant |
US6183255B1 (en) | 2000-03-27 | 2001-02-06 | Yoshiki Oshida | Titanium material implants |
US6350283B1 (en) | 2000-04-19 | 2002-02-26 | Gary K. Michelson | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof |
FR2808673B1 (en) | 2000-05-11 | 2002-12-06 | Scient X | INTERSOMATIC IMPLANT FORE LUMBAR |
EP1284707A4 (en) | 2000-05-30 | 2003-06-25 | Paul S Lin | Implant for placement between cervical vertebrae |
US6579318B2 (en) | 2000-06-12 | 2003-06-17 | Ortho Development Corporation | Intervertebral spacer |
US6808537B2 (en) | 2000-07-07 | 2004-10-26 | Gary Karlin Michelson | Expandable implant with interlocking walls |
US6730127B2 (en) | 2000-07-10 | 2004-05-04 | Gary K. Michelson | Flanged interbody spinal fusion implants |
FR2811543B1 (en) | 2000-07-12 | 2003-07-04 | Spine Next Sa | INTERSOMATIC IMPLANT |
CH694935A5 (en) | 2000-07-26 | 2005-09-30 | Straumann Holding Ag | Oberflaechenmodifizierte implants. |
US7226480B2 (en) | 2000-08-15 | 2007-06-05 | Depuy Spine, Inc. | Disc prosthesis |
US6458159B1 (en) | 2000-08-15 | 2002-10-01 | John S. Thalgott | Disc prosthesis |
AU780317B2 (en) | 2000-09-19 | 2005-03-17 | Eduardo Anitua Aldecoa | Method for surface treatment of implants or prosthesis made of titanium or other materials |
US6743231B1 (en) | 2000-10-02 | 2004-06-01 | Sulzer Spine-Tech Inc. | Temporary spinal fixation apparatuses and methods |
US6743256B2 (en) | 2000-10-11 | 2004-06-01 | Michael D. Mason | Graftless spinal fusion device |
EP1328219A2 (en) | 2000-10-24 | 2003-07-23 | Howmedica Osteonics Corp. | Barrel-shaped apparatus for fusing adjacent bone structure |
US6520993B2 (en) | 2000-12-29 | 2003-02-18 | Depuy Acromed, Inc. | Spinal implant |
US6599322B1 (en) | 2001-01-25 | 2003-07-29 | Tecomet, Inc. | Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone |
US6620332B2 (en) | 2001-01-25 | 2003-09-16 | Tecomet, Inc. | Method for making a mesh-and-plate surgical implant |
IL156148A0 (en) | 2001-01-30 | 2003-12-23 | Synthes Ag | Bone implant, in particular, an inter-vertebral implant |
US6863689B2 (en) | 2001-07-16 | 2005-03-08 | Spinecore, Inc. | Intervertebral spacer having a flexible wire mesh vertebral body contact element |
US6899734B2 (en) | 2001-03-23 | 2005-05-31 | Howmedica Osteonics Corp. | Modular implant for fusing adjacent bone structure |
US7128760B2 (en) | 2001-03-27 | 2006-10-31 | Warsaw Orthopedic, Inc. | Radially expanding interbody spinal fusion implants, instrumentation, and methods of insertion |
US6890355B2 (en) | 2001-04-02 | 2005-05-10 | Gary K. Michelson | Artificial contoured spinal fusion implants made of a material other than bone |
US7083618B2 (en) | 2001-04-06 | 2006-08-01 | Sherwood Services Ag | Vessel sealer and divider |
US6974480B2 (en) | 2001-05-03 | 2005-12-13 | Synthes (Usa) | Intervertebral implant for transforaminal posterior lumbar interbody fusion procedure |
US6719794B2 (en) | 2001-05-03 | 2004-04-13 | Synthes (U.S.A.) | Intervertebral implant for transforaminal posterior lumbar interbody fusion procedure |
US6558424B2 (en) | 2001-06-28 | 2003-05-06 | Depuy Acromed | Modular anatomic fusion device |
US6569201B2 (en) | 2001-09-28 | 2003-05-27 | Depuy Acromed, Inc. | Hybrid composite interbody fusion device |
CN100366300C (en) | 2001-10-11 | 2008-02-06 | 斯特劳曼控股公司 | Bone-seeking implant |
US6709439B2 (en) | 2001-10-30 | 2004-03-23 | Depuy Spine, Inc. | Slaphammer tool |
US20030139812A1 (en) | 2001-11-09 | 2003-07-24 | Javier Garcia | Spinal implant |
US6979353B2 (en) | 2001-12-03 | 2005-12-27 | Howmedica Osteonics Corp. | Apparatus for fusing adjacent bone structures |
US7238203B2 (en) | 2001-12-12 | 2007-07-03 | Vita Special Purpose Corporation | Bioactive spinal implants and method of manufacture thereof |
SE520756C2 (en) | 2001-12-21 | 2003-08-19 | Nobel Biocare Ab | Method of providing surface structure on implants as well as such implants |
US6740118B2 (en) | 2002-01-09 | 2004-05-25 | Sdgi Holdings, Inc. | Intervertebral prosthetic joint |
US6923830B2 (en) | 2002-02-02 | 2005-08-02 | Gary K. Michelson | Spinal fusion implant having deployable bone engaging projections |
US7077864B2 (en) | 2002-02-12 | 2006-07-18 | Cross Medical Products, Inc. | Vertebral interbody cage with translatable locking screw |
US6808538B2 (en) | 2002-03-15 | 2004-10-26 | Stryker Spine | Vertebral body spacer having variable wedged endplates |
US7309358B2 (en) | 2002-03-21 | 2007-12-18 | Warsaw Orthopedic, Inc. | Vertebral body and disc space replacement devices |
US6758862B2 (en) | 2002-03-21 | 2004-07-06 | Sdgi Holdings, Inc. | Vertebral body and disc space replacement devices |
US6991653B2 (en) | 2002-03-21 | 2006-01-31 | Sdgi Holdings, Inc. | Vertebral body and disc space replacement devices |
US6726720B2 (en) | 2002-03-27 | 2004-04-27 | Depuy Spine, Inc. | Modular disc prosthesis |
US7223289B2 (en) | 2002-04-16 | 2007-05-29 | Warsaw Orthopedic, Inc. | Annulus repair systems and techniques |
US6793678B2 (en) | 2002-06-27 | 2004-09-21 | Depuy Acromed, Inc. | Prosthetic intervertebral motion disc having dampening |
US7201775B2 (en) | 2002-09-24 | 2007-04-10 | Bogomir Gorensek | Stabilizing device for intervertebral disc, and methods thereof |
DE10248171A1 (en) | 2002-10-16 | 2004-05-13 | Advanced Medical Technologies Ag | Implant for placement between vertebrae of the spine |
DE10248170A1 (en) | 2002-10-16 | 2004-04-29 | Advanced Medical Technologies Ag | Implant for insertion between vertebras of a spinal column comprises two sides whose outer surfaces at the start of a vertebra spreading process converge towards the free ends of the sides |
US7125425B2 (en) | 2002-10-21 | 2006-10-24 | Sdgi Holdings, Inc. | Systems and techniques for restoring and maintaining intervertebral anatomy |
AR037168A1 (en) | 2002-10-30 | 2004-10-27 | Carrasco Mauricio Rodolfo | IMPLANT FOR VERTEBRAL REPLACEMENT AND RESTORATION OF THE NORMAL SPINAL CURVATURE. |
CA2502292C (en) | 2002-10-31 | 2011-07-26 | Spinal Concepts, Inc. | Movable disc implant |
US20040092941A1 (en) | 2002-11-12 | 2004-05-13 | Jansen Keith E. | Serratome vertebral cortical endplate cutter |
EP1440669B1 (en) | 2003-01-23 | 2006-11-22 | Dinkelacker, Wolfgang, Dr. med. dent. | Bone implant and process for its manufacture |
US7235101B2 (en) | 2003-09-15 | 2007-06-26 | Warsaw Orthopedic, Inc. | Revisable prosthetic device |
JP5079208B2 (en) | 2003-02-24 | 2012-11-21 | デピュイ・プロダクツ・インコーポレイテッド | Metal implant having a rough surface and method for manufacturing the same |
US20040167632A1 (en) | 2003-02-24 | 2004-08-26 | Depuy Products, Inc. | Metallic implants having roughened surfaces and methods for producing the same |
US7819903B2 (en) | 2003-03-31 | 2010-10-26 | Depuy Spine, Inc. | Spinal fixation plate |
US8251700B2 (en) | 2003-05-16 | 2012-08-28 | Biomet 3I, Llc | Surface treatment process for implants made of titanium alloy |
CA2528154A1 (en) | 2003-06-03 | 2005-01-06 | Osteotech, Inc. | Bioimplant with nonuniformly configured protrusions on the load bearing surfaces thereof |
US20040267367A1 (en) | 2003-06-30 | 2004-12-30 | Depuy Acromed, Inc | Intervertebral implant with conformable endplate |
US7806932B2 (en) | 2003-08-01 | 2010-10-05 | Zimmer Spine, Inc. | Spinal implant |
US7041137B2 (en) | 2003-10-07 | 2006-05-09 | Lanx, Llc | Spinal implant |
US7569074B2 (en) | 2003-12-11 | 2009-08-04 | Warsaw Orthopedic, Inc. | Expandable intervertebral implant |
US7137997B2 (en) | 2003-12-29 | 2006-11-21 | Globus Medical, Inc. | Spinal fusion implant |
US7238205B2 (en) | 2004-01-15 | 2007-07-03 | Warsaw Orthopedic, Inc. | Universal interference cleat |
US7250060B2 (en) | 2004-01-27 | 2007-07-31 | Sdgi Holdings, Inc. | Hybrid intervertebral disc system |
US7846183B2 (en) | 2004-02-06 | 2010-12-07 | Spinal Elements, Inc. | Vertebral facet joint prosthesis and method of fixation |
CA2802131C (en) | 2004-02-10 | 2015-10-06 | Spinal Elements, Inc. | System and method for protecting neurovascular structures |
US7833271B2 (en) | 2004-05-04 | 2010-11-16 | Zimmer Spine, Inc. | Spinal implants with body and insert |
US9504583B2 (en) | 2004-06-10 | 2016-11-29 | Spinal Elements, Inc. | Implant and method for facet immobilization |
US20060041313A1 (en) | 2004-08-19 | 2006-02-23 | Sdgi Holdings, Inc. | Intervertebral disc system |
EP1809212A1 (en) | 2004-10-08 | 2007-07-25 | Warsaw Orthopedic, Inc. | Interior connecting interbody cage insertional tools, methods and devices |
CA2583911A1 (en) | 2004-10-28 | 2006-05-11 | Microchips, Inc. | Orthopedic and dental implant devices providing controlled drug delivery |
US7875080B2 (en) | 2004-11-10 | 2011-01-25 | Warsaw Orthopedic, Inc. | Intervertebral spacer |
US20060149372A1 (en) | 2004-12-17 | 2006-07-06 | Paxson Robert D | Artificial spinal disc |
US20060190079A1 (en) | 2005-01-21 | 2006-08-24 | Naim Istephanous | Articulating spinal disc implants with amorphous metal elements |
PT1841385E (en) | 2005-01-28 | 2010-07-01 | Advanced Med Tech | Implant for transforaminal intracorporeal fusion |
DE102005004563B4 (en) | 2005-02-01 | 2017-03-16 | Advanced Medical Technologies Ag | Spreadable implant for preferably dorsal arrangement between the vertebral bodies of the spine |
WO2006091582A2 (en) | 2005-02-24 | 2006-08-31 | Implant Innovations, Inc. | Surface treatment methods for implants made of titanium or titanium alloy |
US20060235409A1 (en) | 2005-03-17 | 2006-10-19 | Jason Blain | Flanged interbody fusion device |
US7749269B2 (en) | 2005-03-28 | 2010-07-06 | Warsaw Orthopedic, Inc. | Spinal system and method including lateral approach |
US20060229715A1 (en) * | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
US20060241760A1 (en) | 2005-04-26 | 2006-10-26 | Brandon Randall | Spinal implant |
WO2006119088A2 (en) | 2005-05-02 | 2006-11-09 | Seaspine, Inc. | Prosthesis for restoring motion |
US7662186B2 (en) | 2005-05-06 | 2010-02-16 | Titan Spine, Llc | Anterior interbody spinal implant |
US20110282454A1 (en) | 2010-05-14 | 2011-11-17 | Titan Spine, Llc | Interbody Spinal Implant Having Internally Textured Surfaces |
US7901462B2 (en) | 2005-06-23 | 2011-03-08 | Depuy Products, Inc. | Implants with textured surface and methods for producing the same |
US7368065B2 (en) | 2005-06-23 | 2008-05-06 | Depuy Products, Inc. | Implants with textured surface and methods for producing the same |
US20060293748A1 (en) | 2005-06-24 | 2006-12-28 | Spineworks, Llc | Prosthetic implant, and a method and tool for the insertion of same |
JP2009509591A (en) | 2005-09-26 | 2009-03-12 | ウォーソー・オーソペディック・インコーポレーテッド | Anterior composite implant |
US7998212B2 (en) | 2005-09-26 | 2011-08-16 | Warsaw Orthopedic, Inc. | Transforaminal hybrid implant |
EP1942840A2 (en) | 2005-09-26 | 2008-07-16 | Warsaw Orthopedic, Inc. | Hybrid intervertebral spinal fusion implant |
US20070093897A1 (en) | 2005-10-21 | 2007-04-26 | Stryker Spine (In France) | System and method for fusion cage implantation |
USD524443S1 (en) | 2005-11-04 | 2006-07-04 | Quantum Orthopedics, Inc. | Interbody fusion device |
USD533277S1 (en) | 2005-11-04 | 2006-12-05 | Quantum Orthopedics, Inc. | Interbody fusion device |
US7967862B2 (en) | 2005-11-23 | 2011-06-28 | Warsaw Orthopedic, Inc. | Posterior articular disc and method for implantation |
WO2007089905A2 (en) | 2006-02-01 | 2007-08-09 | Synthes (U.S.A.) | Interspinous process spacer |
US7850736B2 (en) | 2006-04-13 | 2010-12-14 | Warsaw Orthopedic, Inc. | Vertebral fusion implants and methods of use |
EP1847278A1 (en) | 2006-04-13 | 2007-10-24 | Camlog Biotechnologies AG | Bio-dissolvable salt coatings of implants for the protection against organic impurities |
US8002837B2 (en) | 2006-05-19 | 2011-08-23 | Pioneer Surgical Technology | Spinal stabilization device and methods |
US20080071380A1 (en) | 2006-09-19 | 2008-03-20 | Thomas Sweeney | Systems and Methods for Percutaneous Placement of Interspinous Process Spacers |
US8142355B2 (en) | 2006-09-25 | 2012-03-27 | Spinal Elements, Inc. | Surgical tissue retractor |
US8652137B2 (en) | 2007-02-22 | 2014-02-18 | Spinal Elements, Inc. | Vertebral facet joint drill and method of use |
US8992533B2 (en) | 2007-02-22 | 2015-03-31 | Spinal Elements, Inc. | Vertebral facet joint drill and method of use |
US9358121B2 (en) | 2007-03-10 | 2016-06-07 | Spinesmith Partners, L.P. | Artificial disc with unique articulating geometry and associated methods |
US8211148B2 (en) | 2007-04-24 | 2012-07-03 | Warsaw Orthopedic | Prostheses for locking an artificial disc in an intervertebral disc space |
US8454622B2 (en) | 2007-04-25 | 2013-06-04 | Spinal Elements, Inc. | Spinal implant distractor/inserter |
US8062304B2 (en) | 2007-04-25 | 2011-11-22 | Spinal Elements, Inc. | Spinal implant distractor/inserter |
JP5085730B2 (en) | 2007-06-28 | 2012-11-28 | スピナル エレメンツ,インク. | Spine stabilization device |
EP2022447A1 (en) | 2007-07-09 | 2009-02-11 | Astra Tech AB | Nanosurface |
US8172854B2 (en) | 2007-07-19 | 2012-05-08 | Spinal Elements, Inc. | Attachable instrument guide with detachable handle |
JP2010536533A (en) | 2007-08-24 | 2010-12-02 | スピナル エレメンツ,インク. | Loop rod spinal fixation device |
ES2315194B1 (en) | 2007-09-10 | 2010-02-26 | Francisco J. GARCIA SABAN | PROCEDURE TO OBTAIN A NEW SURFACE OF A METAL IMPLANT BASED ON TITANIUM INTENDED TO BE INSERTED IN OSEO FABRIC. |
US8182534B2 (en) | 2007-09-27 | 2012-05-22 | K2M, Inc. | Orthopedic device assembly with elements coupled by a retaining structure |
US20090187247A1 (en) | 2008-01-23 | 2009-07-23 | Metcalf Jr Newton H | Spinal implant having a resorbable anchor device for temporarily securing an interbody device to adjacent upper and lower vertebrae |
USD599019S1 (en) | 2008-03-07 | 2009-08-25 | Nuvasive, Inc. | Spinal fusion implant |
US8864770B2 (en) | 2008-03-12 | 2014-10-21 | Spinal Elements, Inc. | Offset opposing arm spinal implant distractor/inserter |
US9357985B2 (en) | 2008-05-15 | 2016-06-07 | Spinal Elements, Inc. | Method for accessing a spinal facet joint |
DE102009014184A1 (en) | 2008-11-07 | 2010-05-20 | Advanced Medical Technologies Ag | Implant for fusion of spinal segments |
US8864767B2 (en) | 2008-11-10 | 2014-10-21 | Spinal Elements, Inc. | Rod reducer instrument for spinal surgery |
KR101122494B1 (en) | 2009-02-12 | 2012-02-29 | 서울대학교산학협력단 | Surface Modifying Process of Non-Bioactive Materials |
DE102009011648A1 (en) | 2009-03-04 | 2010-09-09 | Advanced Medical Technologies Ag | Implant system with support elements |
US9220547B2 (en) | 2009-03-27 | 2015-12-29 | Spinal Elements, Inc. | Flanged interbody fusion device |
JP2012524623A (en) | 2009-04-23 | 2012-10-18 | スパイナル・エレメンツ・インコーポレーテッド | Lateral connector |
US8303879B2 (en) | 2010-02-01 | 2012-11-06 | Sb Technologies, Llc | Composite interbody device and method of manufacture |
WO2011116136A1 (en) | 2010-03-16 | 2011-09-22 | Pinnacle Spine Group, Llc | Intervertebral implants and graft delivery systems and methods |
US8641418B2 (en) | 2010-03-29 | 2014-02-04 | Biomet 3I, Llc | Titanium nano-scale etching on an implant surface |
-
2012
- 2012-08-03 US US13/566,384 patent/US20120312779A1/en not_active Abandoned
-
2015
- 2015-11-06 US US14/934,675 patent/US9655745B2/en active Active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258098A (en) * | 1991-06-17 | 1993-11-02 | Cycam, Inc. | Method of production of a surface adapted to promote adhesion |
US5888224A (en) * | 1993-09-21 | 1999-03-30 | Synthesis (U.S.A.) | Implant for intervertebral space |
US5766252A (en) * | 1995-01-24 | 1998-06-16 | Osteonics Corp. | Interbody spinal prosthetic implant and method |
US20020138143A1 (en) * | 1997-08-27 | 2002-09-26 | Grooms Jamie M. | Cortical bone cervical Smith-Robinson fusion implant |
US6168631B1 (en) * | 1997-08-29 | 2001-01-02 | Kinetikos Medical, Inc. | Subtalar implant system and method for insertion and removal |
US20010001315A1 (en) * | 1998-04-23 | 2001-05-17 | Bates James S. | Atraumatic medical retrieval device |
US20030031984A1 (en) * | 1999-08-26 | 2003-02-13 | Richard P. Rusin | Ceramic dental mill blanks |
US20030065401A1 (en) * | 2001-01-25 | 2003-04-03 | Mark Amrich | Textured surface having undercut micro recesses in a surface |
US20050221258A1 (en) * | 2001-07-04 | 2005-10-06 | Nobel Biocare Ab | Implant for example dental implant |
US20080262623A1 (en) * | 2005-05-06 | 2008-10-23 | Titan Spine, Llc | Composite interbody spinal implant having openings of predetermined size and shape |
US20090312842A1 (en) * | 2008-06-16 | 2009-12-17 | Predrag Bursac | Assembled Cartilage Repair Graft |
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