US2735429A - Hypodermic syringes - Google Patents
Hypodermic syringes Download PDFInfo
- Publication number
- US2735429A US2735429A US2735429DA US2735429A US 2735429 A US2735429 A US 2735429A US 2735429D A US2735429D A US 2735429DA US 2735429 A US2735429 A US 2735429A
- Authority
- US
- United States
- Prior art keywords
- stopple
- needle
- barrel
- partitioning
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 description 44
- 238000000638 solvent extraction Methods 0.000 description 38
- 238000002347 injection Methods 0.000 description 16
- 239000007924 injection Substances 0.000 description 16
- 238000010276 construction Methods 0.000 description 12
- 239000000463 material Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 6
- 210000004369 Blood Anatomy 0.000 description 4
- 239000003708 ampul Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000019525 fullness Nutrition 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 210000003205 Muscles Anatomy 0.000 description 2
- 210000003491 Skin Anatomy 0.000 description 2
- 241001408665 Timandra griseata Species 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000003247 decreasing Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000000266 injurious Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000001953 sensory Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/90—Telltale showing entry of blood into body inserted conduit
Definitions
- This invention relates to hypodermic syringes, and it has reference more particularly 'to syringes --of those kinds commonly referred to as one-'shot disposable syringes, that are designed to be used once and lthen thrown away. More specifically, the particular novelty of this invention resides in a new, improved and inexpensive means which makes possible the function of aspiration prior to injection of medicament from the syringe into the patient.
- a syringe comprising a cylindrical barrel and equipped at one end with a Iclosing wall through which av doublepointed, hypodermic needle is sealed, and fitted with a novel and improved form of partitioning stopple which protectively overlies the inner end of the needle, and a piston stopple that is tted in the other end of the barrel and is movable to etteet the function of aspiration and the piercing of the partitioning stopple bythe inner end of the needle and the ultimate forcible ejection ot the medicament, contained in the barrel between the stopples, through the needle.
- the construction and arrangement of parts further providing means whereby the end wall of the partitioning stopple will be pierced by the needle point to permit ejection of the medicament incident to the inward movement of the piston stopple.
- Fig. l is a longitudinal, cross-section view of a oneshot disposable syringe embodying the improvements of the present invention.
- Fig. 2 is an enlarged cross-sectional view of a portion of the forward end portion of the ysyringe illustrating/the end wall of the partitioning stopple in normal position.
- Fig. 3 is an enlarged cross-sectional view similar to Fig. 2 illustrating a partitioning stopple of alternative form.
- Fig. 4 is a longitudinal sectional view of a one-'shot disposable syringe embodying the alternative form 4of partitioning stopple of Fig. 3 with the stopple in normal position. l
- Fig. 5 is an enlarged lcross sectional View illustrating the partitioning stopple of Fig. 3 with the end wall in outwardly cupped position resulting from reduction of pressure in medicament chamber incident to retraction of the piston stopple.
- Fig. 6 illustrates the stopple of Fig. 3 with the 'needle piercing the end wall of the stopple to permit injection of medicament incident to the inward movement ofthe piston stopple.
- Fig. 7 illustrates a syringe assembled 'for aspiration and injection.
- the syringe of this invention comprises a cylindrical barrel 10, preferably of transparent plastic, lor the like, Open at one end and closed at the vother end by an integral end wall il through which a conventional, double-pointed, hypodermic needle 12 is sealed to extend inthe a'xial center line of the barrel; the needle being beveled to sharpened points at both its inner end 13 and its outer end 14.
- a conventional, double-pointed, hypodermic needle 12 is sealed to extend inthe a'xial center line of the barrel; the needle being beveled to sharpened points at both its inner end 13 and its outer end 14.
- the inner end of the needle extends a substantial distance into the interior of the syringe barrel.
- the needle is formed with an arcuate bend as at 12', which is sealed in the end wall 11 to prevent any possible slippage or movement of the needle in the Vend wall.
- the barrel partitioning stopple 20 which -is of transparent, rubber or elastic-like material and vwhich is of sueh diameter as to t in the barrel in relatively tight frictional relationship.
- the partitioning stopple 'comprises the cylindrical body 21; a relatively thin diaphr'a'gtnatic yend wall 22 which in diameter is greater than the interior /diaineter of the cylindrical body portion of the stopple and thus providing a fullness of material that effects a 'reverse cupping of the wall.
- the ⁇ end wall 22 ofthe partitioning stopple 20 must be 'offsuch thickness vor weight of material that relatively sli'gh't increases or decreases in pressure applied thereto will cause the end Wall to change its positionklso as toineiease 'the areas "surrounding the inner end of nthe -needle :and Vthereby canse ha partial vacuum or an area of reduced air pressure surrounding the end of the needle incident to the outward cupping of the end wall as illustrated in Fig. 5.
- the liquid medicament M is contained in the barrel 10, in a medicament chamber 10a between the partitioning stopple 20 and the piston stopple 25, fitted in the outer end portion of the barrel, as is seen in Figs. l, 4, 5 and 6.
- This latter stopple 25 is of rubber, or the like and it is formed with a central, threaded socket 26 open to its outer end.
- the outer end portion of the needle is normally encased in a hollow guard or sheath 30, the inner end portion of which is removably fitted over a central boss or projection 11 on the end wall 11 of the barrel.
- a hollow guard or sheath about this end of the sheath is an annularly projecting ange 31 and at the opposite end of the sheath is a short, threaded stem .32.
- the stem 32 can be threaded into the socket 26 of the stopple 25 to attach the part 30 to the stopple as an operating stem.
- the ange 31 serves as a linger grip in the manipulation of the operating stem.
- the open end of the barrel 10, likewise, is formed with an annular flange 10i and serves as a finger hold.
- a partitioning stopple 20a of slightly modied construction wherein the sealed area immediately surrounding the inner end 13 of the needle 12 is substantially reduced and wherein the stopple is at all times disposed in engagement with the end wall 11 of the barrel.
- the stopple of this construction will permit substantially freer diaphragmatic action of the end wall 22a of the stopple incident to reduced pressures in the medicament chamber a. Also, there will be substantially less compression of air in the sealed area incident to the injection of the medicament.
- the needle sheath, or guard 30 is removed from about the outer end of the needle and its attaching stem 32 is threaded into the socket 26 of the piston stopple 25.
- the parts then assume the relationship as shown in Fig. 7.
- the needle is then inserted into the proper site or location in the muscle of the patient and a slight inward movement is applied to the piston stopple 25 to cause it to move to a position where the end wall 22 of the partitioning stopple barely touches the inner end 13 of the needle.
- Aspiration is then eiected by outward retraction of the stopple by means of the attached member 30.
- the medication is injected by applying inward or injection pressure to the piston actuating stem 30.
- the piston stopple moves inwardly causing the stopple 20 to move inwardly and the end wall 22 is pierced by the inner, pointed end 13 of the needle.
- the continued pressure on the piston stopple discharges the liquid medicament through the needle into the patient.
- injection has been completed the needle is withdrawn from the patient and the syringe in its entirety may be discarded.
- the reduced pressure in the area about the inner end of the needle and the resulting aspiration is affected by the withdrawal of the piston stopple thereby causing a reduced pressure or partial vacuum in the medicament chamber.
- This reduced pressure or vacuum will cause the diaphragmatic end wall of the stopple to be cupped outwardly as shown in Fig. 5 and thereby a reduced pressure area or vacuum is caused in the sealed area or chamber surrounding the inner end of the needle.
- Figs. 4, 5 and 6 The structure illustrated in Figs. 4, 5 and 6 is used in substantially the same manner as the structure of Figs. 1 and 2, except that the partitioning stopple is disposed against the end wall 11 and therefore it is only necessary to retract or move outwardly the piston stopple to cause the reduced pressure in the medicament chamber and the resulting reduced pressure in the area surrounding the inner end of the needle. The stopple is not moved and a tighter seal is possible between the stopple and barrel wall.
- the needle may, if desired, alternatively employ a detachable, bi-pointed needle with screw on hub for its securement to the barrel.
- the needle could, if desired, be reusable.
- the barrel is treated with silicon before loading with the medicament so as to protect the medicament.
- the syringe structure as herein described is practical, easy to use and by reason of the elimination of the requirement for a glass ampule for containing the medicament, it is substantially less complicated in construction and is substantially more economical.
- a hypodermic syringe of the character described comprising a barrel formed with a closing wall at one end and a hypodermic needle sealed through said wall with the inner end of the needle extending into the barrel, a partitioning stopple disposed in the balTel adjacent the said closing wall and a piston stopple normally disposed in the opposite end of the barrel; said partitioning stopple comprising side walls and a diaphragmatic end wall, said end wall being of relatively thin, elastic, transparent material and of substantially greater diameter than the inside diameter of the syringe barrel whereby suicient fullness is provided to effect cupping of the end wall when the stopple is contained within the barrel.
Description
IFeb. 2l, 1956 R. l.. HUBER 2,735,429
HYPODERMIC SYRINGES Filed April 2e, 1954 JNVENToR. Ralph L. Huber By deCeOSed Jennie L. Huber admnisrotrix o* fn/mmf .4free/v51 United States Patent 'O 2,735,429 HYPonnRn/nc SYRINGES VRalph L. Huber, deceased, late of Seattle, Wash., by Jennie L. Huber, administratrix, Seattle, Wash.
Application April 26, 1954, Serial No. 425,444 1 claim. (ci. Ynaam) This invention relates to hypodermic syringes, and it has reference more particularly 'to syringes --of those kinds commonly referred to as one-'shot disposable syringes, that are designed to be used once and lthen thrown away. More specifically, the particular novelty of this invention resides in a new, improved and inexpensive means which makes possible the function of aspiration prior to injection of medicament from the syringe into the patient.
It is the principal object of this invention to provide a hypodermic syringe having a barrel or cylinder with a hypodermic needle sealed therein, yand so equipped with stopples that it serves as a container for the medicament, and eliminates conventional glass ampules commonly used as medicament containers in conjunction with reusable syringes, and means 'is provided for the vnecessary and desirable function V'of aspirating prior to injection of the medicament.
More specically stated, the objects and advantages of the present invention residein the provision of a syringe comprising a cylindrical barrel and equipped at one end with a Iclosing wall through which av doublepointed, hypodermic needle is sealed, and fitted with a novel and improved form of partitioning stopple which protectively overlies the inner end of the needle, and a piston stopple that is tted in the other end of the barrel and is movable to etteet the function of aspiration and the piercing of the partitioning stopple bythe inner end of the needle and the ultimate forcible ejection ot the medicament, contained in the barrel between the stopples, through the needle. l
It is a further object of this invention to provide a hypodermic syringe of the character above ystated wherein the novel and improved form of partitioning stopple is adapted or constructed so as to be effected by slight variations in pressure resulting from the manipulation vof the piston stopple so as to produce an area of decreased pressure surrounding the inner, pointed end of the needle. The construction and arrangement of parts further providing means whereby the end wall of the partitioning stopple will be pierced by the needle point to permit ejection of the medicament incident to the inward movement of the piston stopple.
It is also an object of this invention to provide a new, improved and inexpensive form of partitioning stopple which will protectively overlie the inner, pointed end of the needle and wherein the end wall of the partitioning stopple is of transparent, relatively thin, rubber or elastic type material which will respond to slight variations ot pressure change.
In accomplishing the above mentioned and various other objects of this invention, he has provided the improved details of construction, the preferred forms of which are illustrated in the accompanying drawings, wherein:
Fig. l is a longitudinal, cross-section view of a oneshot disposable syringe embodying the improvements of the present invention.
Fig. 2 is an enlarged cross-sectional view of a portion of the forward end portion of the ysyringe illustrating/the end wall of the partitioning stopple in normal position.
Fig. 3 is an enlarged cross-sectional view similar to Fig. 2 illustrating a partitioning stopple of alternative form.
Fig. 4 is a longitudinal sectional view of a one-'shot disposable syringe embodying the alternative form 4of partitioning stopple of Fig. 3 with the stopple in normal position. l
Fig. 5 is an enlarged lcross sectional View illustrating the partitioning stopple of Fig. 3 with the end wall in outwardly cupped position resulting from reduction of pressure in medicament chamber incident to retraction of the piston stopple.
Fig. 6 illustrates the stopple of Fig. 3 with the 'needle piercing the end wall of the stopple to permit injection of medicament incident to the inward movement ofthe piston stopple. l
Fig. 7 illustrates a syringe assembled 'for aspiration and injection.
Referring more in detail 'to the drawings: 4
In its present preferred form of construction, the syringe of this invention comprises a cylindrical barrel 10, preferably of transparent plastic, lor the like, Open at one end and closed at the vother end by an integral end wall il through which a conventional, double-pointed, hypodermic needle 12 is sealed to extend inthe a'xial center line of the barrel; the needle being beveled to sharpened points at both its inner end 13 and its outer end 14. I t will be noted with reference to Fig. l that the inner end of the needle extends a substantial distance into the interior of the syringe barrel. As herein shown, the needle is formed with an arcuate bend as at 12', which is sealed in the end wall 11 to prevent any possible slippage or movement of the needle in the Vend wall.
Applied Within the barrel, adjacent its end wall, is the barrel partitioning stopple 20 which -is of transparent, rubber or elastic-like material and vwhich is of sueh diameter as to t in the barrel in relatively tight frictional relationship. The partitioning stopple 'comprises the cylindrical body 21; a relatively thin diaphr'a'gtnatic yend wall 22 which in diameter is greater than the interior /diaineter of the cylindrical body portion of the stopple and thus providing a fullness of material that effects a 'reverse cupping of the wall. it is an 'important and necessary feature ofthe invention that the `end wall 22 ofthe partitioning stopple 20 must be 'offsuch thickness vor weight of material that relatively sli'gh't increases or decreases in pressure applied thereto will cause the end Wall to change its positionklso as toineiease 'the areas "surrounding the inner end of nthe -needle :and Vthereby canse ha partial vacuum or an area of reduced air pressure surrounding the end of the needle incident to the outward cupping of the end wall as illustrated in Fig. 5.
The liquid medicament M is contained in the barrel 10, in a medicament chamber 10a between the partitioning stopple 20 and the piston stopple 25, fitted in the outer end portion of the barrel, as is seen in Figs. l, 4, 5 and 6. This latter stopple 25 is of rubber, or the like and it is formed with a central, threaded socket 26 open to its outer end.
As is illustrated in Fig. 1, the outer end portion of the needle is normally encased in a hollow guard or sheath 30, the inner end portion of which is removably fitted over a central boss or projection 11 on the end wall 11 of the barrel. About this end of the sheath is an annularly projecting ange 31 and at the opposite end of the sheath is a short, threaded stem .32. When the sheath has been removed from the needle, the stem 32 can be threaded into the socket 26 of the stopple 25 to attach the part 30 to the stopple as an operating stem. The ange 31 serves as a linger grip in the manipulation of the operating stem. The open end of the barrel 10, likewise, is formed with an annular flange 10i and serves as a finger hold.
In Figs. 4, and 6, there is illustrated a partitioning stopple 20a of slightly modied construction wherein the sealed area immediately surrounding the inner end 13 of the needle 12 is substantially reduced and wherein the stopple is at all times disposed in engagement with the end wall 11 of the barrel. The stopple of this construction will permit substantially freer diaphragmatic action of the end wall 22a of the stopple incident to reduced pressures in the medicament chamber a. Also, there will be substantially less compression of air in the sealed area incident to the injection of the medicament.
With the various parts constructed as shown in Fig. l and with the barrel properly charged with the liquid medicament, and all free air removed from the medicament chamber, the normal use of the syringe would be as follows:
First, the needle sheath, or guard 30, is removed from about the outer end of the needle and its attaching stem 32 is threaded into the socket 26 of the piston stopple 25. The parts then assume the relationship as shown in Fig. 7. The needle is then inserted into the proper site or location in the muscle of the patient and a slight inward movement is applied to the piston stopple 25 to cause it to move to a position where the end wall 22 of the partitioning stopple barely touches the inner end 13 of the needle. Aspiration is then eiected by outward retraction of the stopple by means of the attached member 30. If a drop of blood appears at the inner end of the needle, which blood will be visible through the transparent end wall 22, this is an indication that the needle is in a blood vein and that injection of medicament at this point would be dangerous and injurious to the patient. It is, therefore, required that the needle be slightly withdrawn and its direction slightly changed and again inserted to a proper depth where aspiration can be repeated. This partial withdrawal spares the patient unnecessary pain resulting from repeated penetration of the sensory nerve in the region of the skin surface.
When the needle is properly set, the medication is injected by applying inward or injection pressure to the piston actuating stem 30. When the pressure is applied, the piston stopple moves inwardly causing the stopple 20 to move inwardly and the end wall 22 is pierced by the inner, pointed end 13 of the needle. The continued pressure on the piston stopple discharges the liquid medicament through the needle into the patient. When injection has been completed the needle is withdrawn from the patient and the syringe in its entirety may be discarded.
The reduced pressure in the area about the inner end of the needle and the resulting aspiration is affected by the withdrawal of the piston stopple thereby causing a reduced pressure or partial vacuum in the medicament chamber. This reduced pressure or vacuum will cause the diaphragmatic end wall of the stopple to be cupped outwardly as shown in Fig. 5 and thereby a reduced pressure area or vacuum is caused in the sealed area or chamber surrounding the inner end of the needle.
The structure illustrated in Figs. 4, 5 and 6 is used in substantially the same manner as the structure of Figs. 1 and 2, except that the partitioning stopple is disposed against the end wall 11 and therefore it is only necessary to retract or move outwardly the piston stopple to cause the reduced pressure in the medicament chamber and the resulting reduced pressure in the area surrounding the inner end of the needle. The stopple is not moved and a tighter seal is possible between the stopple and barrel wall.
Instead of the needle herein shown, one may, if desired, alternatively employ a detachable, bi-pointed needle with screw on hub for its securement to the barrel. In such instances, the needle could, if desired, be reusable. Preferably the barrel is treated with silicon before loading with the medicament so as to protect the medicament.
The syringe structure as herein described is practical, easy to use and by reason of the elimination of the requirement for a glass ampule for containing the medicament, it is substantially less complicated in construction and is substantially more economical.
This application is a continuation-impart of allowed application, Serial No. 307,066, led August 29, 1952 and now abandoned.
Having thus described the invention, what is claimed as new therein and desired to secure by Letters Patent is:
A hypodermic syringe of the character described comprising a barrel formed with a closing wall at one end and a hypodermic needle sealed through said wall with the inner end of the needle extending into the barrel, a partitioning stopple disposed in the balTel adjacent the said closing wall and a piston stopple normally disposed in the opposite end of the barrel; said partitioning stopple comprising side walls and a diaphragmatic end wall, said end wall being of relatively thin, elastic, transparent material and of substantially greater diameter than the inside diameter of the syringe barrel whereby suicient fullness is provided to effect cupping of the end wall when the stopple is contained within the barrel.
References Cited in the tile of this patent UNITED STATES PATENTS 1,455,047 Goold May l5, 1923 1,738,146 Kulik Dec. 3, 1929 1,860,898 Meyer May 3l, 1932
Publications (1)
Publication Number | Publication Date |
---|---|
US2735429A true US2735429A (en) | 1956-02-21 |
Family
ID=3444833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US2735429D Expired - Lifetime US2735429A (en) | Hypodermic syringes |
Country Status (1)
Country | Link |
---|---|
US (1) | US2735429A (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3048173A (en) * | 1958-02-17 | 1962-08-07 | Baxter Laboratories Inc | Airway cannula |
US3084688A (en) * | 1959-07-15 | 1963-04-09 | Robert K Mcconnaughey | Disposable hypodermic syringe |
US3308821A (en) * | 1964-03-23 | 1967-03-14 | Walter A Shields | Disposable hypodermic syringes |
US3391695A (en) * | 1966-06-17 | 1968-07-09 | Stanley J. Sarnoff | Cartridge with reflexed burstable diaphragm |
DE1566655B1 (en) * | 1967-10-17 | 1971-02-04 | Philips Nv | Cartridge for injection syringes |
US4059109A (en) * | 1976-07-27 | 1977-11-22 | Tischlinger Edward A | Mixing and dispensing disposable medicament injector |
US4178928A (en) * | 1977-08-10 | 1979-12-18 | Tischlinger Edward A | Self injector |
US4900309A (en) * | 1988-06-02 | 1990-02-13 | Fred Netherton | Needle shield |
US5314410A (en) * | 1992-02-10 | 1994-05-24 | Marks Ronald L | Entry indicator device for arterial or intravenous needle |
WO2010100244A1 (en) * | 2009-03-06 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Seal member for syringe with retractable needle |
WO2017089280A1 (en) * | 2015-11-27 | 2017-06-01 | Sanofi-Aventis Deutschland Gmbh | Injection apparatus |
US20200276389A1 (en) * | 2017-11-21 | 2020-09-03 | Sanofi | A Container for at least a First Injectable Medicament and Injection Device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1455047A (en) * | 1919-10-29 | 1923-05-15 | Luella L Goold | Hypodermic syringe |
US1738146A (en) * | 1923-08-18 | 1929-12-03 | Cook Lab Inc | Hypodermic syringe |
US1860898A (en) * | 1927-06-13 | 1932-05-31 | Winthrop Chem Co Inc | Injection ampul |
-
0
- US US2735429D patent/US2735429A/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1455047A (en) * | 1919-10-29 | 1923-05-15 | Luella L Goold | Hypodermic syringe |
US1738146A (en) * | 1923-08-18 | 1929-12-03 | Cook Lab Inc | Hypodermic syringe |
US1860898A (en) * | 1927-06-13 | 1932-05-31 | Winthrop Chem Co Inc | Injection ampul |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3048173A (en) * | 1958-02-17 | 1962-08-07 | Baxter Laboratories Inc | Airway cannula |
US3084688A (en) * | 1959-07-15 | 1963-04-09 | Robert K Mcconnaughey | Disposable hypodermic syringe |
US3308821A (en) * | 1964-03-23 | 1967-03-14 | Walter A Shields | Disposable hypodermic syringes |
US3391695A (en) * | 1966-06-17 | 1968-07-09 | Stanley J. Sarnoff | Cartridge with reflexed burstable diaphragm |
DE1566655B1 (en) * | 1967-10-17 | 1971-02-04 | Philips Nv | Cartridge for injection syringes |
US4059109A (en) * | 1976-07-27 | 1977-11-22 | Tischlinger Edward A | Mixing and dispensing disposable medicament injector |
US4178928A (en) * | 1977-08-10 | 1979-12-18 | Tischlinger Edward A | Self injector |
US4900309A (en) * | 1988-06-02 | 1990-02-13 | Fred Netherton | Needle shield |
US5314410A (en) * | 1992-02-10 | 1994-05-24 | Marks Ronald L | Entry indicator device for arterial or intravenous needle |
WO2010100244A1 (en) * | 2009-03-06 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Seal member for syringe with retractable needle |
JP2012519512A (en) * | 2009-03-06 | 2012-08-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Seal member for a syringe with a retractable needle |
US8597256B2 (en) | 2009-03-06 | 2013-12-03 | Sanofi-Aventis Deutschland Gmbh | Seal member |
WO2017089280A1 (en) * | 2015-11-27 | 2017-06-01 | Sanofi-Aventis Deutschland Gmbh | Injection apparatus |
CN108495670A (en) * | 2015-11-27 | 2018-09-04 | 赛诺菲-安万特德国有限公司 | Injection device |
US20180344933A1 (en) * | 2015-11-27 | 2018-12-06 | Sanofi-Aventis Deutschland Gmbh | Injection apparatus |
CN108495670B (en) * | 2015-11-27 | 2021-09-28 | 赛诺菲-安万特德国有限公司 | Injection device |
US20200276389A1 (en) * | 2017-11-21 | 2020-09-03 | Sanofi | A Container for at least a First Injectable Medicament and Injection Device |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US2453590A (en) | Hypodermic syringe | |
US5267972A (en) | Hypodermic syringe with needle guard | |
US3439675A (en) | Deformable needle assembly | |
US5246427A (en) | Safety hypodermic needle and shielding cap assembly | |
US4813936A (en) | Retracting hypodermic needle | |
US2834346A (en) | Syringe and hub locking assembly | |
US4227528A (en) | Automatic disposable hypodermic syringe | |
US2735429A (en) | Hypodermic syringes | |
US3977401A (en) | Injection apparatus | |
US4116196A (en) | Additive adapter | |
US5085642A (en) | Conveniently carried frequent use autoinjector | |
EP0379560B1 (en) | Preloaded automatic disposable syringe | |
US4921490A (en) | Safety hypodermic needle syringe | |
US5002536A (en) | Guarded needle cover | |
US5067947A (en) | Syringe plunger rod mount | |
US2798487A (en) | Syringe assembly | |
US2688967A (en) | Metal aspirating syringe | |
GB1263949A (en) | Disposable syringe | |
US10328197B2 (en) | Pen needle to facilitate manipulation by users having physical or visual impairment | |
US5336185A (en) | Protection device for syringe needles | |
US2453591A (en) | Hypodermic syringe | |
US2453589A (en) | Hypodermic syringe and ampoule therefor | |
US4020836A (en) | Apparatus for medical injections | |
US2735428A (en) | A cahsotgo f | |
EP0882467A2 (en) | Syringe for medicinal purposes |