US3365728A - Upholstered heart valve having a sealing ring adapted for dispensing medicaments - Google Patents
Upholstered heart valve having a sealing ring adapted for dispensing medicaments Download PDFInfo
- Publication number
- US3365728A US3365728A US419526A US41952664A US3365728A US 3365728 A US3365728 A US 3365728A US 419526 A US419526 A US 419526A US 41952664 A US41952664 A US 41952664A US 3365728 A US3365728 A US 3365728A
- Authority
- US
- United States
- Prior art keywords
- ring
- valve
- sleeve
- cloth
- upholstered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2421—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with non-pivoting rigid closure members
- A61F2/2424—Ball valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Description
M. L. EDWARDS ETAL 3.365.728 UPHOLSTBRED HEART VALVE HAVING A SEALING RING v ADAPTED FOR DISPENSING MBDICAHBNTS Filed Dec. 18. 1964 INV EN TORS MILES LOWELL EDWARDS y ALBERT sum:
4 Home urn red at ABSTRACT OF THE DISCLOSURE A prosthesis such as a heart valve having an upholstered cushion ring to accommodate and seal against irregularities in the bed of tissue in which the prosthesis is implanted. The cushion ring is suturable and is secured to the prosthesis by being enfolded in a cloth sleeve connected with the rosthesis. The cushion ring may be made of silicone foam rubber capable of absorbing and gradually exuding a medicament such as an anticoagulant or antibiotic.
This invention relates to improvements in a heart valve prosthesis.
Objects of the invention are to provide features that promote healing after implantation, to provide an improved sewing or suture ring for attaching the valve to living tissue, to provide a better seal between the valve and the natural orifice in which it is implanted, to provide an upholstered cushion element in the sewing ring which will readily adjust itself to an irregular contour of the natural orifice, to provide a valve having an effective vehicle for medicament such as anticoagulant drugs or antibiotics and to provide the foregoing features for prostheses other than heart valves.
The present valve comprises a valve ring or body having a movable valve member. Connected to the periphery of the valve ring is a suturable sewing ring by which the valve may be connected by sutures with living tissue around the natural orifice ir which the valve is implanted. The sewing ring is upholstered with a ring of compressible cushion material which will conform to irregularities in the bed in which the valve is placed whereby a good seal is established and leakage between the valve and the tissue is prevented'T-his upholstery ring may be made of a material which may be utilized as a vehicle for medicament such as anticoagulant drugs or antibiotics. An atrioventricular valve is illustrated by way of example, for use in either the mitral or tricuspid positions, but important features of the invention are also applicable to valves for other positions in the heart, such as the aortic valve. The general features of the upholstery ring are also useful in prostheses other than heart valves.
The invention will be better understood and the foregoing and other objects and advantages will become apparent from the following description of the preferred embodiment illustrated on the drawing. Various changes may be made, however, in details of construction and arrangement of parts and certain features may be used without others. All such modifications within the scope of the appended claims are included in the invention.
3,365,728 Patented Jan. 30, 1968 In the drawing:
FIGURE 1 is a perspective view ofan atrioventricular valve prosthesis embodying the features ofthe invention;
FIGURE 2 is a perspective view from a different angle with the ball removed;
FIGURE 3 is an enlarged view on the line 33 of FIGURE 1; and
FIGURE 4 is an enlarged perspective view of the cloth sleeve used for the sewing ring.
The valve comprises, essentially, three parts, these being a valve ring 10, a movable valve member 11 and a suturable sewing ring 12. The valve ring 10 is preferably made of a strong and inert metal such as Stellite which is non-corrodable and has a minimum foreign body reaction with the blood. This ring is preferably cast and includes as an integral part thereof a cage 13. The movable valve member 11 preferably comprises a silicone rubber ball which is confined in the cage 13 and adapted to seat against an annular seating surface 14 in the ring 10. The ring 10 is shaped to provide an outwardly facing channel 15 extending around the ring.
The sewing ring 12 is formed in part of the cloth sleeve shown in FIGURE 4. The material of the sleeve is preferably knitted from a synthetic fiber such as Teflon so as to be freely stretchable. One edge is inturned to form a hem 21. This hemmed edge portion includes a double draw string 22 having free ends 23 available on the outside of the sleeve for tightening the draw string. An intermediate portion of the sleeve is equipped with a double draw string 24 having free ends 25 available on the inside of the sleeve for tightening this draw string. In the opposite edge of the sleeve there is a double draw string 26 having free ends 27 available on the outside of the sleeve.
In constructing the sewing ring the sleeve 20 is first applied over the channel 15 with the hemmed edge 21 overlying the cage 13 and the opposite edge extending beyond the left side of ring 10 in FIGURE 3. The sleeve is positioned so that draw string 24 overlies the channel 15. Then the draw string 24 is tightened and its ends are tied. This holds the sleeve in position for the next oper ation.
A channel-shaped spreader ring 30 is then applied over the cloth in the channel 15. This ring is preferably made directed flange or leg 37. Axial flange 37 is seated on the winding 31 and on the opposite edge portions of spreader ring 30 as shown.
The left end of sleeve 20 is folded over the flange 36 and also over the flange 37, as shown. This end of the sleeve is secured by tightening draw string 26 and tying the ends. Then the hemmed edge 21 is folded over the flange 37 on top of the first layer of cloth and the draw string 22 is tightened and tied. After the hemmed edge 21 is folded over, the knot in draw string 22 will be on the under side of this hem so that the knot may be tucked under and covered by the hem. Finally, the extreme edge of the hem is secured to the underlying layer of cloth by stitching 48 in the corner between flanges 36 and37 and the cloth is pressed to make it lie smoothly on the cushion ring 35. The draw strings and stitching 40 are preferably made of Teflon thread.
in the implantation of the valve in mitral positior, the radial flange 36 is sutured to the annulus of the natural orifice and to the atrium side. The rubber cushion ring 35 conforms to any irregularities of tissue contour which may exist because of disease or other causes and forms an effective seal against the tissue. The layer of cloth 20 overlying the flange 36 provides an effective medium for the ingrowth of tissue over the whole surface of the sewing ring so that, upon healing, the sewing ring becomes permanently connected with the tissue in addition to, and independently of, the applied sutures. Both the cloth 20 cushion ring 35 are capable of expansion and contraction. and distortion in any direction, with natural movements of the supporting tissue during pulsations of the heart so that there is no tendency for the sewing ring to pull loose from the supporting tissue.
The silicone rubber of the cushion ring 35 provides a vehicle for a medicament. The major problems in valve implantation are blood clotting and infection. Silicone rubber has the capacity to absorb an anticoagulant drug, such as heparin. or a suitab e antibiotic, and exude the drug slowly over a relatively long period of time While healing is in progressv "thus. the cushion ring supplies the medicament directly at the point where it is needed. All of the ivelbknown anticoagu ants and antibiotics which are commonly used in heart operations are absorbable in and cxudnblc from silicone rubber. The two types of drugs may he used together in ring 35, if desired.
This characteristic of silicone rubber is inherent in the mturc of the matcri :l and does not depend upon a spongelike porosity to hold the medicament in openings of visible size. The medicament is retained in the body of the rubber and not in the openings resulting from its foamy texture. Preferably, such openings are closed and sealed on the surfaces of the ring by a surface film of the rubber. In this way the rubber cushion element may function effectively as a seal against the leakage of blood and still hold the desired medicament by absorption. However, the rubber may have a somewhat open pore spongelike texture, if desired, and still function effectively as a seal. This type of texture will accommodate ingrowth of tissue throughout the body of the ring. The described scaled surface of the present ring is punctured in many places by sutures in implantation, which affords adequate opportunity for ingrowth.
The cloth itself is not capab e of holding such a medicaient for slow release over a long period of time; If the medicament were to be absorbed into the cloth, it would be quickly washed away into the blood stream and become entirely ineffective long before the need for the medicament ceases to exist. For this reason the cloth is not impregnated with medicament.
The silicone rubber ball 11 may also be employed as a dispenser for absorbed medicament, if desired.
By making suitable changes in the structural details, the principal features of the present construction may be embodied in valves for other positions such as the aortic and in prostheses other than heart valves.
Having now described our invention and in what manner the same may be used, what we claim as new and desire to protect by Letters Patent is:
1. An upholstered heart valve comprising a valve ring hiding a movable valve member, said valve ring having an outwardly facing channel thcrearound, a cloth sleeve, gncans securing an intermediate portion of said sleeve in said channel, a pre'shaped ring of coherent, suturable cushion material of L-shaped crosssection having one leg of the L seated on said securing means and the other leg in outstanding position, the end portions of said sleeve being folded over said cushion ring and over each other in overlapping relation on said seated leg, circumferential draw strings in said overlapped portions of said sleeve, and stitching securing said overlapped portions to each other.
2. An upholstered heart valve comprising a valve ring having a movable valve member, an outwardly facing channel around said ring, a cloth sleeve having a plurality of draw strings, one of said draw strings being tightened in said channel, means clamping a portion of said sleeve in said channel, a pro-shaped suturing and scaling ring of coherent, suturable cushion material enclosed in another portion of said sleeve, and a draw string in said other portion holding said cushion ring to said valve ring.
3. A flanged atrioventricular valve comprising a valve ring having a movable valve member, an outwardly facing channel around said ring, a cloth sleeve having draw strings in its end and intermediate portions, said intermediate draw string being tightened in said channel, means clamping said intermediate portion of said sleeve in said channel, a pre-shaped ring of coherent, suturable cushion material surrounding said clamping means, said cushion ring having a radial flange and an axial flange, one end of said sleeve being folded over said cushion ring and secured on said axial flange by one of said end draw strings, the other end of said sleeve being folded over said axial flange and secured by the other end draw string, and stitches securing said two sleeve ends together in the corner between said two flanges.
4. An upholstered heart valve comprising a valve ring having a movable valve member, said valve ring having an outwardly facing channel therearound, a cloth sleeve having a portion secured in said channel, a pre-shaped ring of coherent, suturable cushion material extending outside of said channel, an annular fold of said sleeve enclosing said cushion ring and securing said cushion ring to said Valve ring, and circumferential draw strings in the portion of said sleeve secured in said channel and in said folded portions of said sleeve.
5. An upholstered heart valve comprising a valve ring having a movable valve member, a cloth having a portion secured around the periphery of said ring and having an outstanding annular fold extending around said periphcry, and a pre-shaped filler ring of coherent, suturable cushion material seated substantially against said valve ring and filling said fold of cloth, said cushion ring imparting shape and body to said fold of cloth but being resilient and compressible to accommodate and seal against irregularities of the bed of tissue in which the valve is placed.
6. A heart valve as defined in claim 5, said cushion ring being made of a molded material.
7. A heart valve as defined in claim 6, said molded material being foam rubber.
8. A heart valve as defined in claim 5, said valve ring having a peripheral channel therearound, and means sccuring said portion of said cloth in said channel.
9. A heart valve as defined in claim 8, said securing means comprising a winding of filamentary material.
10. A heart valve as defined in claim 5, said cloth comprising a sleeve.
11. A heart valve as defined in claim 10, said sleeve containing circumferential draw strings.
(Other references on following page) 5 UNITED STATES PATENTS 3,279,996 10/1966 Long et al. 167--82 3,263,239 8/1966 Edwards et a1 3-1 OTHER REFERENCES Sutureless Aortic and Mitral Prosthetic Valves,
George J. Magovern et al., Journal of Thoracic and Cardiovascular Surgery, vol. 48, No. 3, September 1964, pp. 346-361.
A Hinged-Leaflet Valve for Total Replacement of the Human Aortic Valve by Vincent Goff et al., Journal of Thoracic and Cardiovascular Surgery, vol. 48, No. 5, November 1964, pp. 713-725.
RICHARD A. GAUDET, Primary Examiner.
R. L. FRINKS, Assistant Examiner.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US419526A US3365728A (en) | 1964-12-18 | 1964-12-18 | Upholstered heart valve having a sealing ring adapted for dispensing medicaments |
GB52386/65A GB1067118A (en) | 1964-12-18 | 1965-12-09 | Heart valves |
DE19651491148D DE1491148B1 (en) | 1964-12-18 | 1965-12-17 | Sewing ring for heart valve prostheses |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US419526A US3365728A (en) | 1964-12-18 | 1964-12-18 | Upholstered heart valve having a sealing ring adapted for dispensing medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
US3365728A true US3365728A (en) | 1968-01-30 |
Family
ID=23662646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US419526A Expired - Lifetime US3365728A (en) | 1964-12-18 | 1964-12-18 | Upholstered heart valve having a sealing ring adapted for dispensing medicaments |
Country Status (3)
Country | Link |
---|---|
US (1) | US3365728A (en) |
DE (1) | DE1491148B1 (en) |
GB (1) | GB1067118A (en) |
Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3447161A (en) * | 1966-08-01 | 1969-06-03 | Avco Corp | Disinfectant dispensing percutaneous connector |
US3466671A (en) * | 1966-10-19 | 1969-09-16 | Edwards Lab Inc | Heart valve prosthesis having a cloth covered body |
US3491376A (en) * | 1965-10-06 | 1970-01-27 | Donald P Shiley | Heart valve with separate suturing ring sub-assembly |
US3508281A (en) * | 1968-02-08 | 1970-04-28 | Harry W Cromie | Fabric covered heart valve having an improved fabric seat |
US3509582A (en) * | 1967-07-03 | 1970-05-05 | American Hospital Supply Corp | Heart valve with plastic covered cage legs |
US3524202A (en) * | 1967-05-19 | 1970-08-18 | Harry W Cromie | Prosthetic heart valve |
US3598127A (en) * | 1968-06-06 | 1971-08-10 | James G Wepsic | Catheter having antibacterial substance therein provided with means permitting slow release of said substance |
US3727240A (en) * | 1969-04-21 | 1973-04-17 | Medical Inc | Suturing member for implantable devices such as heart valves |
US3763548A (en) * | 1972-03-17 | 1973-10-09 | L Anderson | Method of mounting a rotatable suturing member on a device |
FR2176871A1 (en) * | 1972-03-17 | 1973-11-02 | Medical Inc | |
US3781969A (en) * | 1972-08-11 | 1974-01-01 | Medical Inc | Method of forming rotatable suturing member on a device |
US3800403A (en) * | 1972-10-10 | 1974-04-02 | Medical Inc | Method of making a suturing member and mounting the suturing member on a device |
US3859668A (en) * | 1972-08-11 | 1975-01-14 | Medical Inc | Rotatable suturing member |
US4278092A (en) * | 1979-07-05 | 1981-07-14 | American Hospital Supply Corporation | Peritoneal catheter |
USRE30912E (en) * | 1968-09-16 | 1982-04-27 | Hancock Laboratories, Inc. | Stent for heart valve |
US4576605A (en) * | 1985-03-01 | 1986-03-18 | Nauchno-Issledovatelsky Institut Khirurgii Imeni A.V. Vishnevskogo | Cardiac valve prosthesis |
US4865600A (en) * | 1981-08-25 | 1989-09-12 | Baxter International Inc. | Mitral valve holder |
US5035709A (en) * | 1990-03-29 | 1991-07-30 | Baxter International Inc. | Mechanical heart valve with compliant sewing ring |
US5258023A (en) * | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
US5306296A (en) * | 1992-08-21 | 1994-04-26 | Medtronic, Inc. | Annuloplasty and suture rings |
US5674279A (en) * | 1992-01-27 | 1997-10-07 | Medtronic, Inc. | Annuloplasty and suture rings |
US5976183A (en) * | 1998-01-05 | 1999-11-02 | Medical Carbon Research Institute, Llc | Sewing ring for heart valve prosthesis |
US6350282B1 (en) * | 1994-04-22 | 2002-02-26 | Medtronic, Inc. | Stented bioprosthetic heart valve |
US20030125805A1 (en) * | 2002-01-02 | 2003-07-03 | Medtronic, Inc. | Heart valve system |
US20040024451A1 (en) * | 2002-01-02 | 2004-02-05 | Medtronic, Inc. | Prosthetic heart valve system |
US7018407B1 (en) | 1981-10-29 | 2006-03-28 | Medtronic | Valve holder for tricuspid heart valve |
US20090076599A1 (en) * | 2007-09-17 | 2009-03-19 | Medtronics, Inc. | Heart valve holder assembly for use in valve implantation procedures |
ITCR20130020A1 (en) * | 2013-09-05 | 2015-03-06 | Matteo Vigna | HEART AND VASCULAR PROSTHESIS AT MINIMUM INFECTIOUS RISK |
WO2017079234A1 (en) | 2015-11-02 | 2017-05-11 | Edwards Lifesciences Corporation | Devices and methods for reducing cardiac valve regurgitation |
WO2017136778A1 (en) | 2016-02-05 | 2017-08-10 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
US9974650B2 (en) | 2015-07-14 | 2018-05-22 | Edwards Lifesciences Corporation | Prosthetic heart valve |
WO2018222799A1 (en) | 2017-05-31 | 2018-12-06 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US10154904B2 (en) | 2014-04-28 | 2018-12-18 | Edwards Lifesciences Corporation | Intravascular introducer devices |
WO2019006387A1 (en) | 2017-06-30 | 2019-01-03 | Edwards Lifesciences Corporation | Docking stations transcatheter valves |
US10179043B2 (en) | 2016-02-12 | 2019-01-15 | Edwards Lifesciences Corporation | Prosthetic heart valve having multi-level sealing member |
US10195025B2 (en) | 2014-05-12 | 2019-02-05 | Edwards Lifesciences Corporation | Prosthetic heart valve |
US10201416B2 (en) | 2016-05-16 | 2019-02-12 | Boston Scientific Scimed, Inc. | Replacement heart valve implant with invertible leaflets |
US10201418B2 (en) | 2010-09-10 | 2019-02-12 | Symetis, SA | Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device |
US10201417B2 (en) | 2015-02-03 | 2019-02-12 | Boston Scientific Scimed Inc. | Prosthetic heart valve having tubular seal |
US10206774B2 (en) | 2003-12-23 | 2019-02-19 | Boston Scientific Scimed Inc. | Low profile heart valve and delivery system |
US10258465B2 (en) | 2003-12-23 | 2019-04-16 | Boston Scientific Scimed Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US10278805B2 (en) | 2000-08-18 | 2019-05-07 | Atritech, Inc. | Expandable implant devices for filtering blood flow from atrial appendages |
US10299922B2 (en) | 2005-12-22 | 2019-05-28 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US10314695B2 (en) | 2003-12-23 | 2019-06-11 | Boston Scientific Scimed Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US10335273B2 (en) | 2003-12-23 | 2019-07-02 | Boston Scientific Scimed Inc. | Leaflet engagement elements and methods for use thereof |
US10413409B2 (en) | 2003-12-23 | 2019-09-17 | Boston Scientific Scimed, Inc. | Systems and methods for delivering a medical implant |
US10426617B2 (en) | 2015-03-06 | 2019-10-01 | Boston Scientific Scimed, Inc. | Low profile valve locking mechanism and commissure assembly |
US10426608B2 (en) | 2003-12-23 | 2019-10-01 | Boston Scientific Scimed, Inc. | Repositionable heart valve |
US10531952B2 (en) | 2004-11-05 | 2020-01-14 | Boston Scientific Scimed, Inc. | Medical devices and delivery systems for delivering medical devices |
US10548734B2 (en) | 2005-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US10555809B2 (en) | 2012-06-19 | 2020-02-11 | Boston Scientific Scimed, Inc. | Replacement heart valve |
US10828154B2 (en) | 2017-06-08 | 2020-11-10 | Boston Scientific Scimed, Inc. | Heart valve implant commissure support structure |
US10898325B2 (en) | 2017-08-01 | 2021-01-26 | Boston Scientific Scimed, Inc. | Medical implant locking mechanism |
US10939996B2 (en) | 2017-08-16 | 2021-03-09 | Boston Scientific Scimed, Inc. | Replacement heart valve commissure assembly |
WO2021050637A1 (en) | 2019-09-13 | 2021-03-18 | Edwards Lifesciences Corporation | Adaptable devices and systems for docking in circulatory system and methods thereof |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
WO2021188278A1 (en) | 2020-03-19 | 2021-09-23 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
US11147668B2 (en) | 2018-02-07 | 2021-10-19 | Boston Scientific Scimed, Inc. | Medical device delivery system with alignment feature |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US11191641B2 (en) | 2018-01-19 | 2021-12-07 | Boston Scientific Scimed, Inc. | Inductance mode deployment sensors for transcatheter valve system |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
US11229517B2 (en) | 2018-05-15 | 2022-01-25 | Boston Scientific Scimed, Inc. | Replacement heart valve commissure assembly |
US11241312B2 (en) | 2018-12-10 | 2022-02-08 | Boston Scientific Scimed, Inc. | Medical device delivery system including a resistance member |
US11241310B2 (en) | 2018-06-13 | 2022-02-08 | Boston Scientific Scimed, Inc. | Replacement heart valve delivery device |
US11246625B2 (en) | 2018-01-19 | 2022-02-15 | Boston Scientific Scimed, Inc. | Medical device delivery system with feedback loop |
US11278398B2 (en) | 2003-12-23 | 2022-03-22 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
WO2022103734A1 (en) | 2020-11-10 | 2022-05-19 | Edwards Lifesciences Corporation | Docking station for a transcatheter heart valve |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US11337834B2 (en) | 2011-12-06 | 2022-05-24 | Aortic Innovations, Llc | Transcatheter valve repair having improved paravalvular seal |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US11439504B2 (en) | 2019-05-10 | 2022-09-13 | Boston Scientific Scimed, Inc. | Replacement heart valve with improved cusp washout and reduced loading |
US11439732B2 (en) | 2018-02-26 | 2022-09-13 | Boston Scientific Scimed, Inc. | Embedded radiopaque marker in adaptive seal |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
WO2023043716A1 (en) | 2021-09-17 | 2023-03-23 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
US11759317B2 (en) | 2016-12-20 | 2023-09-19 | Edwards Lifesciences Corporation | Three-dimensional woven fabric implant devices |
US11771544B2 (en) | 2011-05-05 | 2023-10-03 | Symetis Sa | Method and apparatus for compressing/loading stent-valves |
WO2024058718A1 (en) * | 2022-09-13 | 2024-03-21 | National University Of Singapore | Heart valve prostheses with a drug eluting mechanism |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4759758A (en) * | 1984-12-07 | 1988-07-26 | Shlomo Gabbay | Prosthetic heart valve |
IT1240111B (en) * | 1990-02-21 | 1993-11-27 | Sorin Biomedica Spa | SUTURE RING FOR CARDIAC VALVE PROSTHESES |
US7658727B1 (en) * | 1998-04-20 | 2010-02-09 | Medtronic, Inc | Implantable medical device with enhanced biocompatibility and biostability |
EP1554990A3 (en) * | 1999-01-29 | 2008-08-06 | Medtronic, Inc. | Implantable medical device with enhanced biocompatibility and biostability |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3093831A (en) * | 1959-10-22 | 1963-06-18 | Jordan Gerhard Paul Wilhelm | Artificial gland |
US3099016A (en) * | 1960-08-11 | 1963-07-30 | Edwards Miles Lowell | Heart valve |
US3263239A (en) * | 1963-04-01 | 1966-08-02 | Edwards Lab Inc | Aorta valve with expansible suturing ring |
US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE842525C (en) * | 1950-09-14 | 1952-06-26 | Kopperschmidt & Co Carl W | seal |
-
1964
- 1964-12-18 US US419526A patent/US3365728A/en not_active Expired - Lifetime
-
1965
- 1965-12-09 GB GB52386/65A patent/GB1067118A/en not_active Expired
- 1965-12-17 DE DE19651491148D patent/DE1491148B1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3093831A (en) * | 1959-10-22 | 1963-06-18 | Jordan Gerhard Paul Wilhelm | Artificial gland |
US3099016A (en) * | 1960-08-11 | 1963-07-30 | Edwards Miles Lowell | Heart valve |
US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
US3263239A (en) * | 1963-04-01 | 1966-08-02 | Edwards Lab Inc | Aorta valve with expansible suturing ring |
Cited By (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3491376A (en) * | 1965-10-06 | 1970-01-27 | Donald P Shiley | Heart valve with separate suturing ring sub-assembly |
US3447161A (en) * | 1966-08-01 | 1969-06-03 | Avco Corp | Disinfectant dispensing percutaneous connector |
US3466671A (en) * | 1966-10-19 | 1969-09-16 | Edwards Lab Inc | Heart valve prosthesis having a cloth covered body |
US3524202A (en) * | 1967-05-19 | 1970-08-18 | Harry W Cromie | Prosthetic heart valve |
US3509582A (en) * | 1967-07-03 | 1970-05-05 | American Hospital Supply Corp | Heart valve with plastic covered cage legs |
US3508281A (en) * | 1968-02-08 | 1970-04-28 | Harry W Cromie | Fabric covered heart valve having an improved fabric seat |
US3598127A (en) * | 1968-06-06 | 1971-08-10 | James G Wepsic | Catheter having antibacterial substance therein provided with means permitting slow release of said substance |
USRE30912E (en) * | 1968-09-16 | 1982-04-27 | Hancock Laboratories, Inc. | Stent for heart valve |
US3727240A (en) * | 1969-04-21 | 1973-04-17 | Medical Inc | Suturing member for implantable devices such as heart valves |
US3763548A (en) * | 1972-03-17 | 1973-10-09 | L Anderson | Method of mounting a rotatable suturing member on a device |
FR2176871A1 (en) * | 1972-03-17 | 1973-11-02 | Medical Inc | |
US3781969A (en) * | 1972-08-11 | 1974-01-01 | Medical Inc | Method of forming rotatable suturing member on a device |
US3859668A (en) * | 1972-08-11 | 1975-01-14 | Medical Inc | Rotatable suturing member |
US3800403A (en) * | 1972-10-10 | 1974-04-02 | Medical Inc | Method of making a suturing member and mounting the suturing member on a device |
US4278092A (en) * | 1979-07-05 | 1981-07-14 | American Hospital Supply Corporation | Peritoneal catheter |
US4865600A (en) * | 1981-08-25 | 1989-09-12 | Baxter International Inc. | Mitral valve holder |
USRE42395E1 (en) * | 1981-10-29 | 2011-05-24 | Medtronic, Inc. | Valve holder for tricuspid heart valve |
US7018407B1 (en) | 1981-10-29 | 2006-03-28 | Medtronic | Valve holder for tricuspid heart valve |
US4576605A (en) * | 1985-03-01 | 1986-03-18 | Nauchno-Issledovatelsky Institut Khirurgii Imeni A.V. Vishnevskogo | Cardiac valve prosthesis |
US5035709A (en) * | 1990-03-29 | 1991-07-30 | Baxter International Inc. | Mechanical heart valve with compliant sewing ring |
US5674279A (en) * | 1992-01-27 | 1997-10-07 | Medtronic, Inc. | Annuloplasty and suture rings |
US5258023A (en) * | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
US5306296A (en) * | 1992-08-21 | 1994-04-26 | Medtronic, Inc. | Annuloplasty and suture rings |
US6350282B1 (en) * | 1994-04-22 | 2002-02-26 | Medtronic, Inc. | Stented bioprosthetic heart valve |
US5976183A (en) * | 1998-01-05 | 1999-11-02 | Medical Carbon Research Institute, Llc | Sewing ring for heart valve prosthesis |
US10278805B2 (en) | 2000-08-18 | 2019-05-07 | Atritech, Inc. | Expandable implant devices for filtering blood flow from atrial appendages |
US20060235510A1 (en) * | 2002-01-02 | 2006-10-19 | Johnson Keith M | Prosthetic heart valve system |
US20060195181A1 (en) * | 2002-01-02 | 2006-08-31 | Johnson Keith M | Heart valve system |
US7033390B2 (en) | 2002-01-02 | 2006-04-25 | Medtronic, Inc. | Prosthetic heart valve system |
US7189258B2 (en) | 2002-01-02 | 2007-03-13 | Medtronic, Inc. | Heart valve system |
US7468073B2 (en) | 2002-01-02 | 2008-12-23 | Medtronic, Inc. | Heart valve system |
US7503929B2 (en) | 2002-01-02 | 2009-03-17 | Medtronic, Inc. | Prosthetic heart valve system |
US20040024451A1 (en) * | 2002-01-02 | 2004-02-05 | Medtronic, Inc. | Prosthetic heart valve system |
US20090198323A1 (en) * | 2002-01-02 | 2009-08-06 | Johnson Keith M | Prosthetic Heart Valve System |
US20030125805A1 (en) * | 2002-01-02 | 2003-07-03 | Medtronic, Inc. | Heart valve system |
US8029564B2 (en) | 2002-01-02 | 2011-10-04 | Medtronic, Inc. | Prosthetic heart valve system |
US10335273B2 (en) | 2003-12-23 | 2019-07-02 | Boston Scientific Scimed Inc. | Leaflet engagement elements and methods for use thereof |
US10206774B2 (en) | 2003-12-23 | 2019-02-19 | Boston Scientific Scimed Inc. | Low profile heart valve and delivery system |
US10426608B2 (en) | 2003-12-23 | 2019-10-01 | Boston Scientific Scimed, Inc. | Repositionable heart valve |
US10413409B2 (en) | 2003-12-23 | 2019-09-17 | Boston Scientific Scimed, Inc. | Systems and methods for delivering a medical implant |
US11278398B2 (en) | 2003-12-23 | 2022-03-22 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US11185408B2 (en) | 2003-12-23 | 2021-11-30 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US10314695B2 (en) | 2003-12-23 | 2019-06-11 | Boston Scientific Scimed Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US10258465B2 (en) | 2003-12-23 | 2019-04-16 | Boston Scientific Scimed Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US10531952B2 (en) | 2004-11-05 | 2020-01-14 | Boston Scientific Scimed, Inc. | Medical devices and delivery systems for delivering medical devices |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US10548734B2 (en) | 2005-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US10314701B2 (en) | 2005-12-22 | 2019-06-11 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US10299922B2 (en) | 2005-12-22 | 2019-05-28 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US8273118B2 (en) | 2007-09-17 | 2012-09-25 | Medtronic, Inc. | Heart valve holder assembly for use in valve implantation procedures |
US20090076599A1 (en) * | 2007-09-17 | 2009-03-19 | Medtronics, Inc. | Heart valve holder assembly for use in valve implantation procedures |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11154398B2 (en) | 2008-02-26 | 2021-10-26 | JenaValve Technology. Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
US10869760B2 (en) | 2010-09-10 | 2020-12-22 | Symetis Sa | Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device |
US10201418B2 (en) | 2010-09-10 | 2019-02-12 | Symetis, SA | Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device |
US11771544B2 (en) | 2011-05-05 | 2023-10-03 | Symetis Sa | Method and apparatus for compressing/loading stent-valves |
US11337834B2 (en) | 2011-12-06 | 2022-05-24 | Aortic Innovations, Llc | Transcatheter valve repair having improved paravalvular seal |
US11389310B2 (en) | 2011-12-06 | 2022-07-19 | Aortic Innovations, Llc | Device for aortic repair and method of using the same |
US11497634B2 (en) | 2011-12-06 | 2022-11-15 | Aortic Innovations, Llc | Transcatheter valve repair having improved paravalvular seal |
US11523918B2 (en) | 2011-12-06 | 2022-12-13 | Aortic Innovations, Llc | Transcatheter valve repair having improved paravalvular seal |
US10555809B2 (en) | 2012-06-19 | 2020-02-11 | Boston Scientific Scimed, Inc. | Replacement heart valve |
US11382739B2 (en) | 2012-06-19 | 2022-07-12 | Boston Scientific Scimed, Inc. | Replacement heart valve |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
ITCR20130020A1 (en) * | 2013-09-05 | 2015-03-06 | Matteo Vigna | HEART AND VASCULAR PROSTHESIS AT MINIMUM INFECTIOUS RISK |
US10154904B2 (en) | 2014-04-28 | 2018-12-18 | Edwards Lifesciences Corporation | Intravascular introducer devices |
US11123188B2 (en) | 2014-04-28 | 2021-09-21 | Edwards Lifesciences Corporation | Intravascular introducer devices |
US11103345B2 (en) | 2014-05-12 | 2021-08-31 | Edwards Lifesciences Corporation | Prosthetic heart valve |
US10195025B2 (en) | 2014-05-12 | 2019-02-05 | Edwards Lifesciences Corporation | Prosthetic heart valve |
US10201417B2 (en) | 2015-02-03 | 2019-02-12 | Boston Scientific Scimed Inc. | Prosthetic heart valve having tubular seal |
US10426617B2 (en) | 2015-03-06 | 2019-10-01 | Boston Scientific Scimed, Inc. | Low profile valve locking mechanism and commissure assembly |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US9974650B2 (en) | 2015-07-14 | 2018-05-22 | Edwards Lifesciences Corporation | Prosthetic heart valve |
US11051937B2 (en) | 2015-07-14 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic heart valve |
WO2017079234A1 (en) | 2015-11-02 | 2017-05-11 | Edwards Lifesciences Corporation | Devices and methods for reducing cardiac valve regurgitation |
WO2017136778A1 (en) | 2016-02-05 | 2017-08-10 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
EP4046603A1 (en) | 2016-02-05 | 2022-08-24 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
US11744700B2 (en) | 2016-02-12 | 2023-09-05 | Edwards Lifesciences Corporation | Prosthetic heart valve having multi-level sealing member |
US10179043B2 (en) | 2016-02-12 | 2019-01-15 | Edwards Lifesciences Corporation | Prosthetic heart valve having multi-level sealing member |
US10722354B2 (en) | 2016-02-12 | 2020-07-28 | Edwards Lifesciences Corporation | Prosthetic heart valve having multi-level sealing member |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US10201416B2 (en) | 2016-05-16 | 2019-02-12 | Boston Scientific Scimed, Inc. | Replacement heart valve implant with invertible leaflets |
US10709552B2 (en) | 2016-05-16 | 2020-07-14 | Boston Scientific Scimed, Inc. | Replacement heart valve implant with invertible leaflets |
US11759317B2 (en) | 2016-12-20 | 2023-09-19 | Edwards Lifesciences Corporation | Three-dimensional woven fabric implant devices |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
EP4035629A1 (en) | 2017-05-31 | 2022-08-03 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
EP3639792A1 (en) | 2017-05-31 | 2020-04-22 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
WO2018222799A1 (en) | 2017-05-31 | 2018-12-06 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
EP3878411A1 (en) | 2017-05-31 | 2021-09-15 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
EP4035628A1 (en) | 2017-05-31 | 2022-08-03 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
EP4268770A2 (en) | 2017-05-31 | 2023-11-01 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US10828154B2 (en) | 2017-06-08 | 2020-11-10 | Boston Scientific Scimed, Inc. | Heart valve implant commissure support structure |
EP4292572A2 (en) | 2017-06-30 | 2023-12-20 | Edwards Lifesciences Corporation | Docking stations for transcatheter valves |
WO2019006387A1 (en) | 2017-06-30 | 2019-01-03 | Edwards Lifesciences Corporation | Docking stations transcatheter valves |
US10898325B2 (en) | 2017-08-01 | 2021-01-26 | Boston Scientific Scimed, Inc. | Medical implant locking mechanism |
US10939996B2 (en) | 2017-08-16 | 2021-03-09 | Boston Scientific Scimed, Inc. | Replacement heart valve commissure assembly |
US11191641B2 (en) | 2018-01-19 | 2021-12-07 | Boston Scientific Scimed, Inc. | Inductance mode deployment sensors for transcatheter valve system |
US11246625B2 (en) | 2018-01-19 | 2022-02-15 | Boston Scientific Scimed, Inc. | Medical device delivery system with feedback loop |
US11147668B2 (en) | 2018-02-07 | 2021-10-19 | Boston Scientific Scimed, Inc. | Medical device delivery system with alignment feature |
US11439732B2 (en) | 2018-02-26 | 2022-09-13 | Boston Scientific Scimed, Inc. | Embedded radiopaque marker in adaptive seal |
US11229517B2 (en) | 2018-05-15 | 2022-01-25 | Boston Scientific Scimed, Inc. | Replacement heart valve commissure assembly |
US11241310B2 (en) | 2018-06-13 | 2022-02-08 | Boston Scientific Scimed, Inc. | Replacement heart valve delivery device |
US11241312B2 (en) | 2018-12-10 | 2022-02-08 | Boston Scientific Scimed, Inc. | Medical device delivery system including a resistance member |
US11439504B2 (en) | 2019-05-10 | 2022-09-13 | Boston Scientific Scimed, Inc. | Replacement heart valve with improved cusp washout and reduced loading |
WO2021050637A1 (en) | 2019-09-13 | 2021-03-18 | Edwards Lifesciences Corporation | Adaptable devices and systems for docking in circulatory system and methods thereof |
WO2021188278A1 (en) | 2020-03-19 | 2021-09-23 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
WO2022103734A1 (en) | 2020-11-10 | 2022-05-19 | Edwards Lifesciences Corporation | Docking station for a transcatheter heart valve |
WO2023043716A1 (en) | 2021-09-17 | 2023-03-23 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
WO2024058718A1 (en) * | 2022-09-13 | 2024-03-21 | National University Of Singapore | Heart valve prostheses with a drug eluting mechanism |
Also Published As
Publication number | Publication date |
---|---|
GB1067118A (en) | 1967-05-03 |
DE1491148B1 (en) | 1970-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3365728A (en) | Upholstered heart valve having a sealing ring adapted for dispensing medicaments | |
US6716244B2 (en) | Sewing cuff assembly for heart valves | |
US3996623A (en) | Method of implanting a prosthetic device and suturing member therefor | |
US3466671A (en) | Heart valve prosthesis having a cloth covered body | |
US3371352A (en) | Heart valve for quick implantation having provision for ingrowth of tissue | |
US3099016A (en) | Heart valve | |
CA2265754C (en) | Prosthetic heart valve with suturing member having non-uniform radial width | |
US6350282B1 (en) | Stented bioprosthetic heart valve | |
US5163954A (en) | Suture ring for heart valve prostheses | |
US5147391A (en) | Bioprosthetic heart valve with semi-permeable commissure posts and deformable leaflets | |
JP3405734B2 (en) | Suture ring for pivotable prosthetic heart valve | |
CA1211254A (en) | Suture rings for heart valves | |
JP3701198B2 (en) | Suture ring with improved ring fusion | |
US4635626A (en) | Prosthetic stockings | |
US5035709A (en) | Mechanical heart valve with compliant sewing ring | |
US6187040B1 (en) | Mitral and tricuspid annuloplasty rings | |
US4042979A (en) | Valvuloplasty ring and prosthetic method | |
US11648116B2 (en) | Methods of assembling valved aortic conduits | |
US3781969A (en) | Method of forming rotatable suturing member on a device | |
CN105682609A (en) | Structural members for prosthetic mitral valves | |
JP2003524477A (en) | Artificial heart valve with rotating cuff | |
US2129054A (en) | Colostomy appliance | |
JP2007517595A (en) | Futaba artificial valve and manufacturing method | |
US3723996A (en) | Cloth covered heart valve with protected cage legs | |
JPS59135055A (en) | Low profile biological two peak valves |