US3512524A - Medical device with container rupturing means - Google Patents
Medical device with container rupturing means Download PDFInfo
- Publication number
- US3512524A US3512524A US711044A US3512524DA US3512524A US 3512524 A US3512524 A US 3512524A US 711044 A US711044 A US 711044A US 3512524D A US3512524D A US 3512524DA US 3512524 A US3512524 A US 3512524A
- Authority
- US
- United States
- Prior art keywords
- cover
- container
- needle
- nozzle
- hollow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
Description
' May 19, 1970 y DRII-:wE A 3,512,524
MED-ICAI.; DEVICE WITH CONTAINER RUPTURING MEANS Filed March 6, 1968 2 Sheets-Sheet 1 J. nrEwE May 19,1970- 3,512,524 MEDICAL. nEvIcE WITH CONTAINER nupwnmdums med uam e, 196e 2 Sheets-Shut .2 l
United States Patent Office i 3,512,524 Patented May 19, 1970 3,512,524 MEDICAL DEVICE WITH CONTAINER RUPTURING MEANS John Drewe, Bunh'ngford, England, assignor to Globampoule, A.G., Chur, Switzerland .Filed Mar. 6, 1968, Ser. No. 711,044 Claims priority, application Great Britain, Mar. 14, 1967, 11,983/ 67 Int. Cl. A61m 5/18 U.S. Cl. 12S-216 6 Claims ABSTRACT F THE DISCLOSURE lThe container of a hypodermic syringe or eye-drop dispenser has a hollow projection on the end of which 1 s screwed a nozzle having a hollow needle mounted in 1ts tip and pointing towards the projection. Removably tted on a cylindrical part of the container adjacent the base of the projection is a cover for the projection and nozzle. Rotation of the cover in a given direction first acts through a driving connection to screw the nozzle further onto the projection, causing the needle to pierce the end of the latter, and then frees the driving connection to facilitate removal of the cover.
BACKGROUND OF THE INVENTION This invention relates to medical appliances, such as hypodermic syringes and eye drop dispensers of the kind which, when supplied to the user, have a hollow needle arranged with a pointed end thereof directed towards, but spaced from, a sealed container and which are prepared for use by causing the needle to be displaced relatively to the container so that the said pointed end of the needle pierces the container, thereby establishing communication between the bore of the needle and the interior of the container.
In known hypodermic syringes of this kind for administering injections, the container is filled by the manufacturer under sterile conditions with a predetermined quantity of a liquid medicament before being sealed, the hollow needle is pointed at both ends and the pointed end part remote from that which is directed towards the sealed container projects externally from the syringe, and this externally projecting end part is enclosed within a removable hollow cap or cover to protect it from contamination.
If, however, such a syringe is to be used for taking and storing specimens of blood or other body fluids, the container, before being sealed, instead of being filled with a liquid medicament, may be either wholly or partly lled with air or may be collapsed and evacuated.
Eye drop dispensers of the kind referred to are generally similar to the known hypodermic syringes described above, except that the externally projecting pointed end part is dispensed with and replaced by an outlet end enclosed within and terminating flush with the outlet end of a nozzle part of the body of the dispenser.
With appliances of this kind, the sealed container can be produced under sterile conditions by the manufacturer and the externally projecting end part of the needle or the nozzle end, in the case of eye drop dispensers, is protected from contamination by the cap or cover until the latter is removed. Hitherto, however, diliculty has been experienced in avoiding a break in the sterile chain during the period beginning with the manipulations for causing the needle to pierce the container and ending withV the moment when the needle is injected into the patients body in the case of an injection syringe or device for taking and storing body uids or when the eye drops are administered to the patient in the case of an eye drop dispenser.
The main object of the present invention is therefore to prov1de an improved medical appliance of the kind referred to whereby this dithculty is obviated.
SUMMARY OF THE INVENTION The medical appliance according to this invention includes a sealed, flexible-walled, hollow container having a closed-ended, screw-threaded hollow projection, a needle mounting of relatively rigid material having an internal screw-thread engaged with the outer end part of the screw-thread on the hollow projection, a hollow needle mounted in the outer end part of the needle mounting and having a pointed end part extending through the interior thereof towards the closed end of the hollow projection and a hollow cover enclosing the hollow projection, the needle mounting and the hollow needle, the container having an annular thrust surface for locating the cover, and the cover and the needle mounting being interconnected by a rotary driving connection allowing axial sliding movement between them and so arranged that it becomes disengaged when the needle mounting has been screwed a predetermined distance along the projection towards the container so as to cause the hollow needle to pierce the closed end of the hollow projection.
BRIEF DESCRIPTION OF THE DRAWINGS Preferred embodiments of this invention will now be described by way of example with reference to the accompanying drawing in which:
`FIG. 1 is an axial cross-section illustrating a hypodermic syringe according to one embodiment of this invention,
FIG. 2 is a cross-section on the line II--II in FIG. 1,
FIG. 3 is an axial cross-section illustrating an eye-drop dispenser according to a further embodiment of this in` vention,
FIG. 4 is a side elevation of the eye-drop illustrated in FIG. 3 after preparation for use except for the removal of a cover shown in chain-dotted lines,
FIG. 5 is an axial cross-section corresponding to FIG. 3 illustrating a modification ofthe eye-drop dispenser shown in that figure, and
FIG. 6 is a side elevation corresponding to FIG. 4 of the eye-drop dispenser illustrated in FIG. 5.
DESCRIPTION OF SPECIFIC EMBODIMENTS In FIGS. 1 and 2 a flexible, hollow, bellows-type co1- lapsible container made, for example, from polyethylene is shown at 1. This container 1 is provided at one end Vwith an operating stud 2 and at the other end with a closed-ended hollow projection 3.
The hollow projection 3 is made with a six-start external screw thread 4 which engages with a corresponding internal screw thread of a needle hub 5.
The needle hub 5 coaxially supports a hollow needle 6 which is pointed at both ends so that, when the hollow projection 3 of the container 1 is screwed into the needle hub 5 more than a pre-determined distance, the needle 6 will pierce the closed end of the nozzle 3 of the container. The needle hub 5 is made of a rigid material such as, for example, polystyrene and is provided with line longitudinal serrations, shown at 7.
A protective cover 8 made of a soft flexible material such as, for example, polyethylene is fitted over the needle hub S so as to engage closely with the longitudinal serrations 7. The serrated portion of the needle hub and the portion of the protective. cover engaged therewith are tapered inwardly at a small angle n the direction away from the container.
Connected by a ratchet-toothed coupling 10 to the cover 8 is a hollow finger grip unit 9 which rests against 3 a frusto-conical surface on the front end of the container 1 and encloses the greater part of said container.
When supplied ready for use, the container 1 is sealed with the drug inside, the needle hub with the needle '6 mounted therein is screwed onto the hollow projection 3 of the container 1 such a distance that the pointed rear end of the needle is close to, but not in contact with, the closed end of the hollow projection 3 and the cover 8 is pushed over the needle hub 5, tightly engaging the serrations. The whole assembly is then sealed in an outer package (not shown), typically aluminium/polyethylene foil laminate, and the entire package is sterilized by gamma radiation.
To use the device, the outer wrapping is removed andv discarded. The device can then safely be handled since the hollow projection 3, needle hub 5 and needle 6 are protected from the users hands by means of the cover 8. To pierce the end of the hollow projection 3 and at the same time remove the cover 8, the finger grip unit 9 is turned clockwise relatively to the cover 8, as a result of which the needle hub 5 is screwed further onto the hollow projection 3. The rotation of the cover 8 is transmitted to the needle hub 5 by the engagement of the longitudinal serrations 7 in the latter with the soft material of the cover, while at the same time these serrations allow longitudinal movement of the cover 8 relative to the needle hub 5. When the cover 8 is rotated clockwise relatively to the container 1, the needle hub 5 is screwed onto the nozzle 3, thus causing the rear end of the needle `6 to penetrate through the end of the hollow projection 3, but since the cover 8 is prevented from moving closer to the container 1 by the abutment of the finger grip unit 9 against the container 1, the needle hub 5 will move towards the open end of the cover 8 and at a predetermined position will lose its frictional engagement with the cover 8 which can then be removed. The removal of the cover 8 from the needle hub 5 is facilitated by the fact that, as already mentioned, both the inside of the cover 8 and the serrated portion 7 of the needle hub 5 are formed with a slight inward taper in the direction away from the container 1, or by forming the cover with an enlarged diameter bore 11 near its rear end, or by a combination of both means as illustrated. The final breaking of the frictional engagement takes place when the needle hub 5 is screwed fully home, so that rotation of the needle hub 5 relatively to the cover 8 must take place if the action of rotating cover 8 relatively to the container 1 is continued.
When the cover 8 comes away, the needle hub 5 rwill have been firmly screwed onto the nozzle 3, thus covering the screw thread 4 on the latter and producing a rigid assembly.
The provision of the ratchet drive between the finger grip unit 9 and the cover 8 ensures that the needle hub 5 will not he accidentally unscrewed from the hollow projection 3 and becomes detached together with the cover 8.
When the device is being opened, the finger grip unit 9 will be held in one hand and the cover 8 in the other. After it has been opened, the container can be held by one hand and used forthwith without any need to touch the needle hub 5. l m
In the case of a syringe to be used for taking samples of body uids, the arrangement of the needle hub, needle and cover may be as described above, lbut the sealed container will be wholly or partly filled with air or evacuated.
Referring to FIGS. 3 and 4, a flexible hollow container 21 made, for example, from polyethylene has a short hollow projection 22 at one end and a longer hollow projection 23 at its other end. The container is made with the endA wall of the projection 22 open for filling and the end wall of the projection 23 closed. After filling, the opening in the end wall of the projection 22 is sealed, e.g. by heat.
The hollow projection 23 of the container is made |with an external screw thread which engages with the internal screw tread of a nozzle 24.
The nozzle 24 is made so that a short hollow needle 25, mounted in a ferrule 26, may be assembled into its outer end and so arranged that, when the hollow projection 23 of the container 21 is screwed into the nozzle 24 more than a predetermined distance, the mounted needle 25 will pierce the end wall of the hollow projection 23.
The nozzle 24 is made of a rigid material such as, for example, polystyrene and is provided with fine longitudinal serrations, shown at 27.
A protective cover 28 made of a soft flexible material such as, for example, polyethylene can be fitted over the nozzle 24 so that a part 30 thereof engages closely with the longitudinal serrations 27. The interior diameter of that part 31 of the cover 28 which extends between the part 30 and the open end of the cover is enlarged so that there is a small clearance between the serrated circumference of the nozzle 24 and the interior surface of the said part 30. Consequently, an annular step 32 is also formed between the parts 30 and 31.
When supplied ready for use, the container 21 is sealed with the drug inside, the nozzle 24 with the needle 25 mounted therein as already described is screwed onto the end of the hollow projection 23 such a distance that the tip of the needle 25 is close to, but not in contact with, the end wall of the hollow projection 23 and the cover 28 is pushed over the nozzle 24, tightly engaging the serrations 27, until its open end engages a shoulder 29 on the container 21. The assembly is then sealed in an outer package (not shown), composed for example of aluminium/polythene foil laminate, and the entire package is sterilized by gamma radiation.
To use the device, the outer wrapping is removed and discarded. The device can then safely be handled since the nozzle-end is protected from the users hands by means of the cover 28. To pierce the end of the hollow projection 23 of the container and at the same time remove the cover 28, the container 21 is rotated relatively to the cover 28 in such a direction as to cause the nozzle 24 to be screwed further on to the hollow projection 23. The rotation of the cover 28 is transmitted to the nozzle 24 by the engagement of the longitudinal serrations 27 in the latter with the soft material of the cover, while at the same time these serrations allow longitudinal movement of the cover 28 relative to the hollow projection 23. When the cover 28 is rotated relatively to the container 21, the nozzle 24 is screwed onto the hollow projection 23 of the container, thus causing the needle 25 to penetrate through the end wall of the said projection 23, but since the cover 28 is prevented from moving closer to the container 21 by the abutment of the open end of the cover 28 against the shoulder 29, the nozzle 24 will move towards the opened end of the cover 28 until it is screwed fully home on the projection 23, as shown in FIG. 4. The nozzle 24 will then lose its driving engagement with the cover 28, due to the serrations 27 on the nozzle having been displaced past the annular step 32 into a position opposite the enlarged diameter interior surface part 31 of the cover. The final breaking of the frictional engagement between the cover 28 and the nozzle 24 occurs when the nozzle 24 is screwed fully home, so that rotation of the nozzle relatively to the cover 28 must take place if the action of rotating the container relatively to the cover is continued.
As soon as the frictional engagement between the cover 28 and the nozzle 24 is broken, the cover 28 becomes freely removable in the direction away from the container 21.
Before the cover 28 cornes away, the nozzle 24 will have been firmly screwed onto the hollow projection 23 of the container, thus covering the screw thread on the hollow projection and producing a rigid assembly.
When the device is being opened, the cover 28 will be held in one hand and the container 21 in the other. After it has been opened, the container 21 lwill still be held by one hand and can be used forthwith without moving the fingers and with no need to touch the nozzle 24.
The embodiment illustrated in FIGS. and 6, differs from that illustrated in FIGS. 3 and 4 in that the serrated portion 27 of the nozzle 24' and the interior surface 30 of the cover 28 are both formed with a slight inward taper in the direction away from the container 21. Thus, in the assembly as supplied to the user (FIG. 5), a rotary driving connection is provided between the tapered serrated portion 27 of the nozzle 24' and the interior surface part of the cover 28', which driving connection nevertheless permits relative axial displacement of the nozzle 24 with respect of the cover 28. When, however, the nozzle 24 has been screwed firmly home, as shown in FIG. 6, this rotary driving connection will be disengaged, due to the smaller diameter part of the serrated portion 27 of the nozzle 24' having been displaced into a position within the larger diameter part of the interior of the cover 28', and the cover 28 can be freely removed.
What is claimed is:
1. A medical appliance, comprising a sealed, eXible-walled, hollow container having a closed-ended, screw-threaded hollow projection,
a grip unit surrounding the container,
a needle mounting of relatively rigid material having an internal screw-thread engaged with the outer end part of the screw-threaded hollow projection,
a hollow needle mounted in the outer end part of the needle mounting and having a pointed end part extending through the interior thereof towards the closed end of the hollow projection,
a hollow cover removably and rotatably mounted on the grip unit and enclosing the hollow projection, the needle mounting and the hollow needle,
and coupling means for transmitting rotation from the cover to the needle mounting, while permitting axial displacement of the needle mounting with respect to the cover, so as to cause the needle mounting to be screwed a predetermined distance along the hollow projection for effecting the piercing of the closed end of the latter by the said pointed end part of the hollow needle,
the container having an annular abutment surface coaxial with the hollow projection and serving to limit axial sliding movement of the cover towards the container, and
the coupling means being, arranged to become disconnected when the needle mounting has been screwed through the said predetermined distance along the hollow projection.
2. A medical appliance according to claim 1, wherein the cover is made of relatively soft material, and
the rotary driving connection is formed by longitudinal serrations on the outer surface of the needle mounting which engage in an interior surface part of the cover.
3. A medical appliance according to claim 2, wherein a part of the cover between the part thereof 'by which it is rotatably mounted on the container and the said interior surface part is of enlarged internal diameter, 'and an annular step formed between said first-mentioned and last-mentioned parts is so located that the rotary driving connection between the nozzle and the cover is disengaged when the nozzle is screwed fully home after the needle has pierced the closed end of the hollow projection.
4. A medical appliance according to claim 2, wherein both the interior surface of the cover and the serrated external surface of the needle mounting are tapered inwardly in the `direction away from the container so that the rotary driving connection between the nozzle and the cover is disengaged when the nozzle is screwed fully home after the needle has pierced the closed end part of the hollow projection.
5. A medical appliance according to claim 1 in which lsaid hollow finger grip unit surrounds the front part of the container, and
ratchet drive means between the nger grip and the cover so that rotation of the finger grip in only one direction relatively to the container is transmitted to the cover.
6. A medical appliance according to claim 5, wherein an interior end surface of the finger grip unit is arranged to engage an annular thrust surface on the container, and
cooperating end thrust surfaces are provided on the finger grip unit and cover adjacent the ratchet drive so that the cover is located through the intermediary of the finger grip unit against axial displacement towards the container.
References Cited FOREIGN PATENTS 210,267 1/1957 Australia.
LAWRENCE W. TRAPP, Primary Examiner G. F. DUNNE, Assistant Examiner U.S. C1. X.R.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1198367 | 1967-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3512524A true US3512524A (en) | 1970-05-19 |
Family
ID=9996269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US711044A Expired - Lifetime US3512524A (en) | 1967-03-14 | 1968-03-06 | Medical device with container rupturing means |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3512524A (en) |
| GB (1) | GB1217152A (en) |
Cited By (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3724460A (en) * | 1968-11-14 | 1973-04-03 | American Home Prod | Disposable cartridge for admixing two components of injectable medicament |
| US3845763A (en) * | 1973-02-28 | 1974-11-05 | Nasco Plastics Inc | Syringe with puncturable stem |
| US3934585A (en) * | 1970-08-13 | 1976-01-27 | Maurice David M | Method and apparatus for application of eye drops |
| US4307763A (en) * | 1979-11-29 | 1981-12-29 | International Business Machines Corporation | Toner container |
| US4704104A (en) * | 1986-03-20 | 1987-11-03 | Christensen John F | Disposable tube for rectal injection of drugs |
| US4714461A (en) * | 1985-11-07 | 1987-12-22 | Becton, Dickinson And Company | Catheter assembly with air purging feature |
| US4759751A (en) * | 1985-11-07 | 1988-07-26 | Becton, Dickinson And Company | Catheter assembly with air purging feature |
| US4883473A (en) * | 1987-04-29 | 1989-11-28 | Path | Single use injection device |
| US4955871A (en) * | 1987-04-29 | 1990-09-11 | Path | Single-use disposable syringe |
| US5190521A (en) * | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5201717A (en) * | 1990-12-05 | 1993-04-13 | Philip Wyatt | Safety enclosure |
| US5250037A (en) * | 1992-12-18 | 1993-10-05 | Becton, Dickinson And Company | Syringe having needle isolation features |
| US5307953A (en) * | 1991-12-03 | 1994-05-03 | Glaxo Group Limited | Single dose dispenser having a piercing member |
| US5505694A (en) * | 1990-08-22 | 1996-04-09 | Tcnl Technologies, Inc. | Apparatus and method for raising a skin wheal |
| US5545152A (en) * | 1994-10-28 | 1996-08-13 | Minimed Inc. | Quick-connect coupling for a medication infusion system |
| USD380262S (en) * | 1995-06-26 | 1997-06-24 | Minimed Inc. | Quick disconnect coupling |
| US5836922A (en) * | 1995-06-21 | 1998-11-17 | Bernd Hansen | Container for delivery of flowable material |
| US5848993A (en) * | 1997-08-07 | 1998-12-15 | Deroyal Industries, Inc. | Bulb syringe providing for visual observation of contents thereof and for enhanced deflation/inflation control |
| USD432646S (en) * | 1999-02-26 | 2000-10-24 | Barry Farris | Syringe with air trap |
| US6312412B1 (en) | 1998-12-02 | 2001-11-06 | V. C. Saied, M.D. | Apparatus and method for painless intramuscular or subcutaneous injections |
| US20020117513A1 (en) * | 2001-02-28 | 2002-08-29 | Michael Helmlinger | Dispenser for media |
| US20040078024A1 (en) * | 2002-10-22 | 2004-04-22 | Francesco Peluso | Formed, filled, sealed solution container, port and method for establishing flow between the container and an administration set |
| US20050283132A1 (en) * | 2002-10-22 | 2005-12-22 | Stanus J B P | Access port with safety tab and fluid container employing same |
| US20070051362A1 (en) * | 2004-04-23 | 2007-03-08 | Sullivan Timothy R | Multiple unit dose drug delivery system |
| US20080058732A1 (en) * | 2006-08-30 | 2008-03-06 | Arthur Harris | Continuous Feed Hypodermic Syringe with Self Contained Cartridge Dispenser |
| US20080177246A1 (en) * | 2007-01-09 | 2008-07-24 | First City Tower | Intranasal Cartridge Devices |
| US20090071108A1 (en) * | 2007-09-14 | 2009-03-19 | Mystic Pharmaceuticals, Inc. | Deep draw container forming method |
| US20090098250A1 (en) * | 2007-10-04 | 2009-04-16 | Daniel Py | Method for formulating and aseptically filling liquid products |
| US20090105684A1 (en) * | 2007-10-23 | 2009-04-23 | Baxter International Inc. | Medication port for medical fluid container |
| US7669597B2 (en) | 2007-05-16 | 2010-03-02 | Mystic Pharmaceuticals, Inc. | Combination unit dose dispensing containers |
| US7942861B2 (en) | 2002-10-22 | 2011-05-17 | Baxter International Inc. | Fluid container with access port and safety cap |
| US8683995B2 (en) | 2007-05-16 | 2014-04-01 | Mystic Pharmaceuticals, Inc. | Dose dispensing containers |
| US9248076B2 (en) | 2007-05-16 | 2016-02-02 | Mystic Pharmaceuticals, Inc. | Dose dispensing containers |
| US20170007766A1 (en) * | 2014-03-04 | 2017-01-12 | Merck Sharp & Dohme Corp. | Prefilled disposable injection device |
| USD828653S1 (en) * | 2016-12-14 | 2018-09-11 | Brandon Penland | Treatment applicator |
| US10569069B2 (en) | 2016-12-14 | 2020-02-25 | Combat Comb, Llc | Applicator for treatments applied to animal skin |
| US20220265023A1 (en) * | 2021-02-22 | 2022-08-25 | Epic Brands, Llc | Applicator and assembly for flexible container |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290257A (en) * | 1992-01-02 | 1994-03-01 | Zhong Being Tang | Method and apparatus for de-airing the heart |
| ITBS20070024A1 (en) | 2007-02-26 | 2008-08-27 | Fabio Boldini | INSTRUMENT FOR INJECTION WITH RETRACTABLE NEEDLE AFTER USE |
-
1967
- 1967-03-14 GB GB29170/67A patent/GB1217152A/en not_active Expired
-
1968
- 1968-03-06 US US711044A patent/US3512524A/en not_active Expired - Lifetime
Cited By (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| USD828653S1 (en) * | 2016-12-14 | 2018-09-11 | Brandon Penland | Treatment applicator |
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| US20220265023A1 (en) * | 2021-02-22 | 2022-08-25 | Epic Brands, Llc | Applicator and assembly for flexible container |
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Also Published As
| Publication number | Publication date |
|---|---|
| GB1217152A (en) | 1970-12-31 |
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