US3659602A - Two component syringe - Google Patents

Two component syringe Download PDF

Info

Publication number
US3659602A
US3659602A US3659602DA US3659602A US 3659602 A US3659602 A US 3659602A US 3659602D A US3659602D A US 3659602DA US 3659602 A US3659602 A US 3659602A
Authority
US
United States
Prior art keywords
vial
needle
piston
cylindrical wall
post
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Harold S Cloyd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nosco Plastics Inc
Original Assignee
Nosco Plastics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nosco Plastics Inc filed Critical Nosco Plastics Inc
Application granted granted Critical
Publication of US3659602A publication Critical patent/US3659602A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing

Definitions

  • ABSTRACT Field of Search .,128/218, 218 P, 218 M, 218 D, A two component syringe having two vials each containing 21 128/218 N, 220 Single component.
  • a needle is mounted in the syringe and is arranged to interconnect the vials prior to mixing the contents 56] References Cited thereof.
  • One vial is mounted on a holder having a needle hub.
  • the other vial is mounted on an adapter sleeve removably UNITED STATES PATENTS mounted on the needle hub.
  • This invention is intended to provide a syringe assembly in which two vials of the type forming an inverted syringe are initially connected by a holder having a double ended needle for establishing communication between the vials.
  • the holder is provided with means for attaching the plunger of the first vial so as to resist thrust in both directions and thereby permit aspiration.
  • the plunger of the second vial is connected to the holder through a removable sleeve so that when the contents of the vials have been mixed and discharged into the first vial, the sleeve and second vial may be removed, leaving the first vial and holder in condition for injection.
  • FIG. 1 is a longitudinal section through atwo component syringe assembly prior to mixing of the components
  • FIG. 2 is a longitudinal section through the syringe in readiness for injection.
  • FIG. 1 at its upper end shows the glass via] 1 which is to be used for the injection of a mixture of two ingredients.
  • the lower end of the vial is closed-by a rubber or other suitable piston 2 having a diaphragm 3 normally sealing a needle passageway 4, 5.
  • the via] 1 contains one of the ingredients to be mixed.
  • FIG. 1 At the lower end of FIG. 1 is a substantially identical vial having its lower end sealed by a rubber piston and having a diaphragm 3a normally sealing a needle passageway 44.
  • the vial la contains the other ingredient to be mixed with the ingredient contained in vial 1 prior to administration.
  • the vials so far described are or may be of common construction.
  • a plastic holder 6 such as shown in my copending application Ser. No. 749,448 filed Aug. 1, 1968, incorporated by reference, for receiving the vial 1 and an associated adapter sleeve 7 for receiving the vial 1a.
  • the holder 6 has a cylindrical body 6 with finger gripping projections 8 at its upper end and a needle hub 9 at its lower end.
  • the body 6a telescopically receives the vial 1 and is integral with a solid plastic post 10 having longitudinal external guide ribs 10a.
  • the needle hub 9 is at the lower end of the post 10 in which is embedded and anchored a double ended needle 11 with the lower end l2projecting out through the needle hub 9 and with the upper end 13 terminating within or slightly above an upwardly presented socket 14.
  • the socket l4 and a projection 16 at the lower end of the piston 2 are provided with interlocking means such as screw threads 17, 18 which, when engaged, connect the piston 2 and the socket 14 in axial thrust resisting relation so that reciprocation of the vial l relative to the post causes corresponding reciprocation of the vial 1 relative to the piston 2.
  • interlocking means such as screw threads 17, 18 which, when engaged, connect the piston 2 and the socket 14 in axial thrust resisting relation so that reciprocation of the vial l relative to the post causes corresponding reciprocation of the vial 1 relative to the piston 2.
  • This means that the reciprocation of the vial relative to the post can cause both suction to aspirate into the needle or pressure to expel out through the needle.
  • the adapter sleeve 7 has its upper end removably received on a Luer taper 19 on the lower end of the needle hub 9 and has its lower end provided with a socket 20 for receiving the upper end 21 of the piston 2a.
  • the socket 20 and the piston end 21 could be of the same construction as the socket 14 and projection 16. That is not necessary since the vial 1a is to be thrown away prior to use of the syrings for injection.
  • the pointed end 12 of the needle 11 Prior to use, is normally partially within the passageway 50 short of the diaphragm 3a. When the vial 1a is pushed toward the needle hub 9, the pointed end 12 of the needle punctures the diaphragm 3a.
  • the parts are normally shipped in the partially assembled condition shown in FIG. 1 with the vials l and 10 containing theseparate ingredients which are to be mixed prior to injection.
  • One of these ingredients is usually a solution and the other may be a concentrate or a powder.
  • the ingredients are such that the mixture must be used promptly after mixing.
  • a sealing sleeve 22 for vial 1 has one end in sealing engagement with the open end of vial l and has the opposite or reduced diameter end 23 telescoped over the socket 14. The telescoping engagement with the vial and socket provides a seal. In this position, the
  • a similar sealing sleeve 22a is telescoped over the open end of vial 1a and has its reduced diameter end 234 telescoped over the socket 20 on the adapter sleeve 7.
  • the telescoping engagement of the sealing sleeve 22a with the vial 1a and socket 20 provides a seal protecting the needle point 12 and the adjacent portion of the vial 1a from contamination.
  • the adapter sleeve requires pushing the viall toward the socket so that the pro- 20 jection 16 starts to enter the socket and then rotating the vial to screw the projection into the socket and thereby establish a connection between the piston and the socket which will stand axial thrust in opposite directions.
  • the pointed end 13 of the needle .11 penetrates the diaphragm 3 and establishes communication between the needle 11 and the contents of the vial 1.
  • the second step is to push the vial 1a into the socket 20 until it bottoms.
  • the needle end 12 penetrates the diaphragm 3a and thereby establishes communication between the needle and the contents of the vial 10.
  • the ingredients may now be mixed. This may be done by first expellingthe contents of vial 1a into vial 1 by pressure exerted on vial 1a and then by expelling the contents of vial 1 back into vial -laby pressure exerted on vial 1.
  • the guide ribs 10a on the post 10 cooperate with the sealing sleeve 22and similar guide ribs 21 on adapter sleeve 7 cooperate with the'sealing sleeve 22a to guide the reciprocation of the vials 1 and 1a and the associated sleeves 22 and 22a.
  • the final-step should end with expulsion of the contents of vial la back-into viall.
  • a syringe assembly having a solid plastic post with a needle hub at one end of the post and a first part of a coupling at the other end of the post, a double ended needle having one end of the-needle projecting from the first coupling part and the other end of the needle projecting out through the hub and the intermediate portion of the needle embedded and anchored in the post, a first vial having a closed end remote from the first coupling part and a cylindrical wall telescoped over the first coupling part and post, a first piston in sliding sealing relation to the cylindrical wall of the first vial, said first piston having a second coupling part,said first and second coupling parts having interlocking means for connecting the parts to stand axial forces in opposite direction whereby after connecting the parts subsequent reciprocation of the first vial relative to the post causes corresponding reciprocation of the first vial relative to the first piston, said first piston having a portion penetrated by said one end of the needle as its said second coupling part is connected with said first coupling part to establish communication between the needle and the
  • the assembly of claim 1 having a sleeve with one end surrounding and telescopically receiving the open end of the first vial and the other end surrounding and telescopically receiving the first coupling part to provide a sliding telescoping seal between the post and the cylindrical wall of the first vial.

Abstract

A two component syringe having two vials each containing a single component. A needle is mounted in the syringe and is arranged to interconnect the vials prior to mixing the contents thereof. One vial is mounted on a holder having a needle hub. The other vial is mounted on an adapter sleeve removably mounted on the needle hub. The adapter sleeve and the other vial are removed after the ingredients have been mixed, leaving the first vial with the associated needle in readiness for injection.

Description

D United States Patent [151 3,659,602 Cloyd 1 May 2, 1972 54] TWO COMPONENT SYRINGE 3,080,866 3/1963 Friedman ..128/218 0 3,336,924 8/1967 Sarnofi et a1. [72] Inventor: Harold S. (-Iloyd, Ene, Pa. 3'376866 4/1968 Ogle [73] Assignee: Nosco Plastics, Incorporated, Erie, Pa. 3,378,008 4/1968 Ogle ..128/220 [22] Filed: Dec. 30, 1970 FOREIGN PATENTS OR APPLICATIONS [21] App1.No.: 94,942 526,191 2/1954 Belgium 128/220 1,167,766 8/1958 France ...128/2l8 M Related U.S. Application Data 1,074,027 5/1960 Germany ..128/220 [63] gontilnuation of Ser. No. 848,446, Aug. 8, 1969, aban- Primary m p S. Reich one Attorney-Ralph I-Iammar [52] U.S. Cl ..128/220 1 a [51] Int. Cl. ..A61m 05/18 [57] ABSTRACT [58] Field of Search .,128/218, 218 P, 218 M, 218 D, A two component syringe having two vials each containing 21 128/218 N, 220 Single component. A needle is mounted in the syringe and is arranged to interconnect the vials prior to mixing the contents 56] References Cited thereof. One vial is mounted on a holder having a needle hub. The other vial is mounted on an adapter sleeve removably UNITED STATES PATENTS mounted on the needle hub. The adapter sleeve and the other vial are removed after the ingredients have been mixed, leav- 6/1889 KloPpe "128/ 220 ing the first vial with the associated needle in readiness for in- 2,696,213 12/1954 Smith jectiom 2,954,299 9/1960 Metten..... 3,074,541 1/1963 Roehr ..128/218 D UX 6 Claims, 2 Drawing Figures Patented May 2, 1972 ill (I INgENTOR. W H
TWO COMPONENT SYRINGE This application is a streamline continuation of application Ser. No. 848,446, filed Aug. 8, 1969 and now abandoned.
This invention is intended to provide a syringe assembly in which two vials of the type forming an inverted syringe are initially connected by a holder having a double ended needle for establishing communication between the vials. The holder is provided with means for attaching the plunger of the first vial so as to resist thrust in both directions and thereby permit aspiration. The plunger of the second vial is connected to the holder through a removable sleeve so that when the contents of the vials have been mixed and discharged into the first vial, the sleeve and second vial may be removed, leaving the first vial and holder in condition for injection.
In the drawing,
FIG. 1 is a longitudinal section through atwo component syringe assembly prior to mixing of the components, and
FIG. 2 is a longitudinal section through the syringe in readiness for injection.
FIG. 1 at its upper end shows the glass via] 1 which is to be used for the injection of a mixture of two ingredients. The lower end of the vial is closed-by a rubber or other suitable piston 2 having a diaphragm 3 normally sealing a needle passageway 4, 5. The via] 1 contains one of the ingredients to be mixed.
At the lower end of FIG. 1 is a substantially identical vial having its lower end sealed by a rubber piston and having a diaphragm 3a normally sealing a needle passageway 44. The vial la contains the other ingredient to be mixed with the ingredient contained in vial 1 prior to administration. The vials so far described are or may be of common construction.
Between the vials l and la is a plastic holder 6 such as shown in my copending application Ser. No. 749,448 filed Aug. 1, 1968, incorporated by reference, for receiving the vial 1 and an associated adapter sleeve 7 for receiving the vial 1a.
The holder 6 has a cylindrical body 6 with finger gripping projections 8 at its upper end and a needle hub 9 at its lower end. The body 6a telescopically receives the vial 1 and is integral with a solid plastic post 10 having longitudinal external guide ribs 10a. The needle hub 9 is at the lower end of the post 10 in which is embedded and anchored a double ended needle 11 with the lower end l2projecting out through the needle hub 9 and with the upper end 13 terminating within or slightly above an upwardly presented socket 14. The socket l4 and a projection 16 at the lower end of the piston 2 are provided with interlocking means such as screw threads 17, 18 which, when engaged, connect the piston 2 and the socket 14 in axial thrust resisting relation so that reciprocation of the vial l relative to the post causes corresponding reciprocation of the vial 1 relative to the piston 2. This means that the reciprocation of the vial relative to the post can cause both suction to aspirate into the needle or pressure to expel out through the needle.
The adapter sleeve 7 has its upper end removably received on a Luer taper 19 on the lower end of the needle hub 9 and has its lower end provided with a socket 20 for receiving the upper end 21 of the piston 2a. The socket 20 and the piston end 21 could be of the same construction as the socket 14 and projection 16. That is not necessary since the vial 1a is to be thrown away prior to use of the syrings for injection. Prior to use, the pointed end 12 of the needle 11 is normally partially within the passageway 50 short of the diaphragm 3a. When the vial 1a is pushed toward the needle hub 9, the pointed end 12 of the needle punctures the diaphragm 3a.
The parts are normally shipped in the partially assembled condition shown in FIG. 1 with the vials l and 10 containing theseparate ingredients which are to be mixed prior to injection. One of these ingredients is usually a solution and the other may be a concentrate or a powder. The ingredients are such that the mixture must be used promptly after mixing.
in the partially assembled condition, a sealing sleeve 22 for vial 1 has one end in sealing engagement with the open end of vial l and has the opposite or reduced diameter end 23 telescoped over the socket 14. The telescoping engagement with the vial and socket provides a seal. In this position, the
pointed end 130i the needle 11 partially enters the needle passageway 5 but does not enter the sealing diaphragm 3. A similar sealing sleeve 22a is telescoped over the open end of vial 1a and has its reduced diameter end 234 telescoped over the socket 20 on the adapter sleeve 7. The telescoping engagement of the sealing sleeve 22a with the vial 1a and socket 20 provides a seal protecting the needle point 12 and the adjacent portion of the vial 1a from contamination. The adapter sleeve requires pushing the viall toward the socket so that the pro- 20 jection 16 starts to enter the socket and then rotating the vial to screw the projection into the socket and thereby establish a connection between the piston and the socket which will stand axial thrust in opposite directions. As the projection 16 is screwed into the socket 14, the pointed end 13 of the needle .11 penetrates the diaphragm 3 and establishes communication between the needle 11 and the contents of the vial 1. The second step is to push the vial 1a into the socket 20 until it bottoms. As the needle end 12 penetrates the diaphragm 3a and thereby establishes communication between the needle and the contents of the vial 10. With the establishment of communication through'the needle of the contents of vials 1 and la, the ingredients may now be mixed. This may be done by first expellingthe contents of vial 1a into vial 1 by pressure exerted on vial 1a and then by expelling the contents of vial 1 back into vial -laby pressure exerted on vial 1. This sequence may be repeated as manytimes as necessary to insure thorough mixing. The guide ribs 10a on the post 10 cooperate with the sealing sleeve 22and similar guide ribs 21 on adapter sleeve 7 cooperate with the'sealing sleeve 22a to guide the reciprocation of the vials 1 and 1a and the associated sleeves 22 and 22a. The final-step should end with expulsion of the contents of vial la back-into viall. Then, by removing the adapter sleeve 7 fromLuer taper 19 on needle hub 9 and throwing away the adapter .sleeve 7 and the associated vial 1a, the remaining'parts consisting of the vial l and the holder 6 are now in condition for injection of the mixed ingredients as shown in FIG. 2.
What is claimed is:
l. A syringe assembly having a solid plastic post with a needle hub at one end of the post and a first part of a coupling at the other end of the post, a double ended needle having one end of the-needle projecting from the first coupling part and the other end of the needle projecting out through the hub and the intermediate portion of the needle embedded and anchored in the post, a first vial having a closed end remote from the first coupling part and a cylindrical wall telescoped over the first coupling part and post, a first piston in sliding sealing relation to the cylindrical wall of the first vial, said first piston having a second coupling part,said first and second coupling parts having interlocking means for connecting the parts to stand axial forces in opposite direction whereby after connecting the parts subsequent reciprocation of the first vial relative to the post causes corresponding reciprocation of the first vial relative to the first piston, said first piston having a portion penetrated by said one end of the needle as its said second coupling part is connected with said first coupling part to establish communication between the needle and the first vial, a second vial having a closed end remote from the needle hub and a cylindrical wall and means for removably telescoping said second vial over said other end of the needle, a second piston in sliding sealing relation to the cylindrical wall of the second vial, said second piston having a portion penetrated by said other end of the needle to establish communication between the needle and the second vial as the cylindrical wall of the second vial is telescoped over said other end of the needle, one of said vials containing a first ingredient and the other of the vials containing a second ingredient which may be mixed with the first ingredient by reciprocating the vials afier establishing communication between the needle and both vials, a holder fixed to the post having a cylindrical wall surrounding the first vial in telescoping relation, said assembly being conditioned for injection by expelling into the first vial the contents of the second vial and then removing the second vial from the assembly.
2. The assembly of claim 1 having a sleeve with one end surrounding and telescopically receiving the open end of the first vial and the other end surrounding and telescopically receiving the first coupling part to provide a sliding telescoping seal between the post and the cylindrical wall of the first vial.
3. The assembly of claim 1 having a sleeve with one end surrounding and telescopically receiving the open end of the second vial and the other end surrounding and telescopically receiving a member associated with the needle hub to provide a sliding telescoping seal between the hub and the cylindrical wall of the second vial.
4. The assembly of claim 3 in which said member is an intermediate sleeve removably seated on the needle hub and surrounding said other end of the needle.
5. The assembly of claim 4 in which the intermediate sleeve has a socket adjacent said other end of the needle receiving said portion of the second piston as the cylindrical wall of the second vial is telescoped over said other end of the needle.
6. The assembly of claim 1 in which one of the coupling parts is a socket and the other of the coupling parts is a projection on the piston adapted to be received in said socket.

Claims (6)

1. A syringe assembly having a solid plastic post with a needle hub at one end of the post and a first part of a coupling at the other end of the post, a double ended needle having one end of the needle projecting from the first coupling part and the other end of the needle projecting out through the hub and the intermediate portion of the needle embedded and anchored in the post, a first vial having a closed end remote from the first coupling part and a cylindrical wall telescoped over the first coupling part and post, a first piston in sliding sealing relation to the cylindrical wall of the first vial, said first piston having a second coupling part, said first and second coupling parts having interlocking means for connecting the parts to stand axial forces in opposite direction whereby after connecting the parts subsequent reciprocation of the first vial relative to the post causes corresponding reciprocation of the first vial relative to the first piston, said first piston having a portion penetrated by said one end of the needle as its said second coupling part is connected with said first coupling part to establish communication between the needle and the first vial, a second vial having a closed end remote from the needle hub and a cylindrical wall and means for removably telescoping said second vial over said other end of the needle, a second piston in sliding sealing relation to the cylindrical wall of the second vial, said second piston having a portion penetrated by said other end of the needle to establish communication between the needle and the second vial as the cylindrical wall of the second vial is telescoped over said other end of the needle, one of said vials containing a first ingredient and the other of the vials containing a second ingredient which may be mixed with the first ingredient by reciprocating the vials after establishing communication between the needle and both vials, a holder fixed to the post having a cylindrical wall surrounding the first vial in telescoping relation, said assembly being conditioned for injection by expelling into the first vial the contents of the second vial and then removing the second vial from the assembly.
2. The assembly of claim 1 having a sleeve with one end surrounding and telescopically receiving the open end of the first vial and the other end surrounding and telescopically receiving the first coupling part to provide a sliding telescoping seal between the post and the cylindrical wall of the first vial.
3. The assembly of claim 1 having a sleeve with one end surrounding and telescopically receiving the open end of the second vial and the other end surrounding and telescopically receiving a member associated with the needle hub to provide a sliding telescoping seal between the hub and the cylindrical wall of the second vial.
4. The assembly of claim 3 in which said member is an intermediate sleeve removably seated on the needle hub and surrounding said other end of the needle.
5. The assembly of claim 4 in which the intermediate sleeve has a socket adjacent said other end of the needle receiving said portion of the second piston as the cylindrical wall of the second vial is telescoped over said other end of the needle.
6. The assembly of claim 1 in which one of the coupling parts is a socket and the other of the coupling parts is a projection on the piston adapted to be received in said socket.
US3659602D 1970-12-30 1970-12-30 Two component syringe Expired - Lifetime US3659602A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9494270A 1970-12-30 1970-12-30

Publications (1)

Publication Number Publication Date
US3659602A true US3659602A (en) 1972-05-02

Family

ID=22248079

Family Applications (1)

Application Number Title Priority Date Filing Date
US3659602D Expired - Lifetime US3659602A (en) 1970-12-30 1970-12-30 Two component syringe

Country Status (1)

Country Link
US (1) US3659602A (en)

Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3739780A (en) * 1972-02-07 1973-06-19 Ims Ltd Saf-t-jet
US3828779A (en) * 1972-12-13 1974-08-13 Ims Ltd Flex-o-jet
US3858582A (en) * 1972-12-13 1975-01-07 Ims Ltd Cartridge vaccine injector
US3870044A (en) * 1971-08-13 1975-03-11 Burron Medical Prod Inc Hypodermic syringe body structure
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
US3976073A (en) * 1974-05-01 1976-08-24 Baxter Laboratories, Inc. Vial and syringe connector assembly
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
US4467588A (en) * 1982-04-06 1984-08-28 Baxter Travenol Laboratories, Inc. Separated packaging and sterile processing for liquid-powder mixing
EP0161797A2 (en) * 1984-04-16 1985-11-21 Rudolph J. Kopfer Anti-aerosoling drug reconstitution device
US4994029A (en) * 1989-09-12 1991-02-19 David Bull Laboratories Pty. Ltd. Syringe mixer and injector device
EP0422657A1 (en) * 1989-10-13 1991-04-17 International Medication Systems Ltd Apparatus for storing, mixing, and using medication
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
WO1992011897A1 (en) * 1990-12-26 1992-07-23 Abbott Laboratories Drug storage and delivery system
US5380281A (en) * 1991-04-09 1995-01-10 Bracco, S.P.A. Device for the administration of drugs, particularly two-component drugs
US5569191A (en) * 1992-12-15 1996-10-29 Meyer; Gabriel Device for preparing a medicinal substance solution, suspension or emulsion
US5688254A (en) * 1983-01-24 1997-11-18 Icu Medical, Inc. Medical connector
WO2000013723A3 (en) * 1998-09-04 2000-07-06 Owen Mumford Ltd Improvements relating to fluid tranfer assemblies
US20040006330A1 (en) * 2000-07-11 2004-01-08 Fangrow Thomas F Medical valve with positive flow characteristics
US20040073174A1 (en) * 1991-12-18 2004-04-15 Lopez George A. Medical valve and method of use
US20050197646A1 (en) * 2002-02-11 2005-09-08 Brian Connell Dialysis connector with retention and feedback features
US20060079834A1 (en) * 2004-10-13 2006-04-13 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US20060161115A1 (en) * 2004-11-05 2006-07-20 Fangrow Thomas F Soft-grip medical connector
US20060200090A1 (en) * 1996-12-16 2006-09-07 Lopez George A Positive flow valve
US20060212006A1 (en) * 1996-12-16 2006-09-21 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US20070167910A1 (en) * 2005-11-09 2007-07-19 Hyprotek, Inc. Syringe Devices, Components of Syringe Devices, and Methods of Forming Components and Syringe Devices
US20100130918A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from supply containers and associated fill tubing
US20100130919A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from the patient's peritoneal cavity
US8002737B2 (en) 2007-10-04 2011-08-23 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US8002765B2 (en) 1995-12-15 2011-08-23 Icu Medical, Inc. Medical valve with fluid escape space
USD644731S1 (en) 2010-03-23 2011-09-06 Icu Medical, Inc. Medical connector
US8105314B2 (en) 2006-10-25 2012-01-31 Icu Medical, Inc. Medical connector
US8454579B2 (en) 2009-03-25 2013-06-04 Icu Medical, Inc. Medical connector with automatic valves and volume regulator
US8758306B2 (en) 2010-05-17 2014-06-24 Icu Medical, Inc. Medical connectors and methods of use
US9522097B2 (en) 2007-10-04 2016-12-20 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
USD786427S1 (en) 2014-12-03 2017-05-09 Icu Medical, Inc. Fluid manifold
USD793551S1 (en) 2014-12-03 2017-08-01 Icu Medical, Inc. Fluid manifold
US10369349B2 (en) 2013-12-11 2019-08-06 Icu Medical, Inc. Medical fluid manifold
US10485597B2 (en) 2003-03-31 2019-11-26 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US10494158B2 (en) * 2006-10-19 2019-12-03 DePuy Synthes Products, Inc. Fluid delivery system
US10631906B2 (en) 2005-11-22 2020-04-28 DePuy Synthes Products, Inc. Apparatus for transferring a viscous material
US10799278B2 (en) 2003-03-14 2020-10-13 DePuy Synthes Products, Inc. Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US11213631B2 (en) 2017-06-13 2022-01-04 Difinity Solutions Inc. Protected needle assembly for a hypodermic needle
US11759570B2 (en) 2019-02-25 2023-09-19 Difinity Solutions Inc. Medicament injector and interchangeable cartridges therefor

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE526191A (en) *
US405100A (en) * 1889-06-11 Otto kloppe
US2696213A (en) * 1951-12-26 1954-12-07 Arthur E Smith Disposable syringe
FR1167766A (en) * 1956-10-31 1958-11-28 Improvements to syringes and devices used for mixing and injecting extemporaneous drugs
DE1074027B (en) * 1960-01-28 Chemische Werke Hüls Aktiengesellschaft, Marl (Kr. Recklinghausen) Process and device for the continuous oxidation of n-butane in the liquid phase
US2954299A (en) * 1958-07-10 1960-09-27 Gen Foods Corp Process of preparing a chiffon dessert product and the resulting product
US3074541A (en) * 1959-10-13 1963-01-22 Brunswick Corp Medicinal vial and needle assembly
US3080866A (en) * 1961-07-07 1963-03-12 Friedman Benjamin Hypodermic needle
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3376866A (en) * 1965-07-23 1968-04-09 Robert W. Ogle Medicament injector with attached vial

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE526191A (en) *
US405100A (en) * 1889-06-11 Otto kloppe
DE1074027B (en) * 1960-01-28 Chemische Werke Hüls Aktiengesellschaft, Marl (Kr. Recklinghausen) Process and device for the continuous oxidation of n-butane in the liquid phase
US2696213A (en) * 1951-12-26 1954-12-07 Arthur E Smith Disposable syringe
FR1167766A (en) * 1956-10-31 1958-11-28 Improvements to syringes and devices used for mixing and injecting extemporaneous drugs
US2954299A (en) * 1958-07-10 1960-09-27 Gen Foods Corp Process of preparing a chiffon dessert product and the resulting product
US3074541A (en) * 1959-10-13 1963-01-22 Brunswick Corp Medicinal vial and needle assembly
US3080866A (en) * 1961-07-07 1963-03-12 Friedman Benjamin Hypodermic needle
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3376866A (en) * 1965-07-23 1968-04-09 Robert W. Ogle Medicament injector with attached vial
US3378008A (en) * 1965-07-23 1968-04-16 Min I Jet Corp Hypodermic syringe with vial

Cited By (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
US3870044A (en) * 1971-08-13 1975-03-11 Burron Medical Prod Inc Hypodermic syringe body structure
US3739780A (en) * 1972-02-07 1973-06-19 Ims Ltd Saf-t-jet
US3828779A (en) * 1972-12-13 1974-08-13 Ims Ltd Flex-o-jet
US3858582A (en) * 1972-12-13 1975-01-07 Ims Ltd Cartridge vaccine injector
US3945382A (en) * 1972-12-13 1976-03-23 Ims Limited Device for introduction of liquid medication into a flexible bag
US3976073A (en) * 1974-05-01 1976-08-24 Baxter Laboratories, Inc. Vial and syringe connector assembly
US4432755A (en) * 1982-04-06 1984-02-21 Baxter Travenol Laboratories, Inc. Sterile coupling
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
WO1983003540A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Sterile coupling
WO1983003586A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Closed drug delivery system
US4458733A (en) * 1982-04-06 1984-07-10 Baxter Travenol Laboratories, Inc. Mixing apparatus
US4467588A (en) * 1982-04-06 1984-08-28 Baxter Travenol Laboratories, Inc. Separated packaging and sterile processing for liquid-powder mixing
US4484920A (en) * 1982-04-06 1984-11-27 Baxter Travenol Laboratories, Inc. Container for mixing a liquid and a solid
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
US5688254A (en) * 1983-01-24 1997-11-18 Icu Medical, Inc. Medical connector
EP0161797A2 (en) * 1984-04-16 1985-11-21 Rudolph J. Kopfer Anti-aerosoling drug reconstitution device
US4619651A (en) * 1984-04-16 1986-10-28 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
EP0161797A3 (en) * 1984-04-16 1986-07-09 Rudolph J. Kopfer Anti-aerosoling drug reconstitution device
US4994029A (en) * 1989-09-12 1991-02-19 David Bull Laboratories Pty. Ltd. Syringe mixer and injector device
EP0422657A1 (en) * 1989-10-13 1991-04-17 International Medication Systems Ltd Apparatus for storing, mixing, and using medication
WO1992011897A1 (en) * 1990-12-26 1992-07-23 Abbott Laboratories Drug storage and delivery system
US5171214A (en) * 1990-12-26 1992-12-15 Abbott Laboratories Drug storage and delivery system
US5380281A (en) * 1991-04-09 1995-01-10 Bracco, S.P.A. Device for the administration of drugs, particularly two-component drugs
US20040243070A1 (en) * 1991-12-18 2004-12-02 Lopez George A. Medical valve and method of use
US7717883B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US7713247B2 (en) 1991-12-18 2010-05-11 Icu Medical, Inc. Medical valve and method of use
US7713248B2 (en) 1991-12-18 2010-05-11 Icu Medical, Inc. Medical valve and method of use
US7717884B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US20040073174A1 (en) * 1991-12-18 2004-04-15 Lopez George A. Medical valve and method of use
US7713249B2 (en) 1991-12-18 2010-05-11 Icu Medical, Inc. Medical valve and method of use
US20060206058A1 (en) * 1991-12-18 2006-09-14 Lopez George A Medical valve and method of use
US7722575B2 (en) 1991-12-18 2010-05-25 Icu Medical, Inc. Medical valve and method of use
US7717886B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US7717887B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US7717885B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US7722576B2 (en) 1991-12-18 2010-05-25 Icu Medical, Inc. Medical valve and method of use
US5569191A (en) * 1992-12-15 1996-10-29 Meyer; Gabriel Device for preparing a medicinal substance solution, suspension or emulsion
US8002765B2 (en) 1995-12-15 2011-08-23 Icu Medical, Inc. Medical valve with fluid escape space
US20060264849A1 (en) * 1996-12-16 2006-11-23 Lopez George A Positive flow valve
US20060212006A1 (en) * 1996-12-16 2006-09-21 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US20060200090A1 (en) * 1996-12-16 2006-09-07 Lopez George A Positive flow valve
US20060206061A1 (en) * 1996-12-16 2006-09-14 Lopez George A Positive flow valve
WO2000013723A3 (en) * 1998-09-04 2000-07-06 Owen Mumford Ltd Improvements relating to fluid tranfer assemblies
US20060276757A1 (en) * 2000-07-11 2006-12-07 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US8870850B2 (en) 2000-07-11 2014-10-28 Icu Medical, Inc. Medical connector
US20060264844A1 (en) * 2000-07-11 2006-11-23 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US20060212001A1 (en) * 2000-07-11 2006-09-21 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US7763199B2 (en) 2000-07-11 2010-07-27 Icu Medical, Inc. Method of making a seal having slit formed therein
US20060276758A1 (en) * 2000-07-11 2006-12-07 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US20060264842A1 (en) * 2000-07-11 2006-11-23 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US20060224127A1 (en) * 2000-07-11 2006-10-05 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US8444628B2 (en) 2000-07-11 2013-05-21 Icu Medical, Inc. Needleless medical connector
US8221391B2 (en) 2000-07-11 2012-07-17 Icu Medical, Inc. Needleless medical connector
US9238129B2 (en) 2000-07-11 2016-01-19 Icu Medical, Inc. Medical connector
US20060004331A1 (en) * 2000-07-11 2006-01-05 Fangrow Thomas F Jr Medical valve with positive flow characteristics
US6916309B2 (en) 2000-07-11 2005-07-12 Icu Medical, Inc. Medical valve with positive flow characteristics
US6695817B1 (en) 2000-07-11 2004-02-24 Icu Medical, Inc. Medical valve with positive flow characteristics
US20040030321A1 (en) * 2000-07-11 2004-02-12 Fangrow Thomas F. Medical valve with positive flow characteristics
US7497849B2 (en) 2000-07-11 2009-03-03 Icu Medical, Inc. High flow rate needleless medical connector
US7628774B2 (en) 2000-07-11 2009-12-08 Icu Medical, Inc. Needleless Medical Connector
US20040006330A1 (en) * 2000-07-11 2004-01-08 Fangrow Thomas F Medical valve with positive flow characteristics
US20050197646A1 (en) * 2002-02-11 2005-09-08 Brian Connell Dialysis connector with retention and feedback features
US7708714B2 (en) 2002-02-11 2010-05-04 Baxter International Inc. Dialysis connector with retention and feedback features
US10799278B2 (en) 2003-03-14 2020-10-13 DePuy Synthes Products, Inc. Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US10485597B2 (en) 2003-03-31 2019-11-26 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US20060079834A1 (en) * 2004-10-13 2006-04-13 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7731678B2 (en) * 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US20070255203A1 (en) * 2004-10-13 2007-11-01 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US20070255226A1 (en) * 2004-10-13 2007-11-01 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US20070249996A1 (en) * 2004-10-13 2007-10-25 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US9861555B2 (en) 2004-10-13 2018-01-09 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US20070265578A1 (en) * 2004-10-13 2007-11-15 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US20070276322A1 (en) * 2004-10-13 2007-11-29 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US7635344B2 (en) 2004-10-13 2009-12-22 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US20070260176A1 (en) * 2004-10-13 2007-11-08 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US7731679B2 (en) 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7749189B2 (en) 2004-10-13 2010-07-06 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7753891B2 (en) 2004-10-13 2010-07-13 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US11376195B2 (en) 2004-10-13 2022-07-05 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7776011B2 (en) 2004-10-13 2010-08-17 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US8231567B2 (en) 2004-10-13 2012-07-31 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7985211B2 (en) 2004-10-13 2011-07-26 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US20070112313A1 (en) * 2004-11-05 2007-05-17 Fangrow Thomas F Soft-grip medical connector
US11883623B2 (en) 2004-11-05 2024-01-30 Icu Medical, Inc. Medical connector
US10722698B2 (en) 2004-11-05 2020-07-28 Icu Medical, Inc. Medical connector
US9415200B2 (en) 2004-11-05 2016-08-16 Icu Medical, Inc. Medical connector
US9186494B2 (en) 2004-11-05 2015-11-17 Icu Medical, Inc. Medical connector
US20060264910A1 (en) * 2004-11-05 2006-11-23 Fangrow Thomas F Soft-grip medical connector
US7824393B2 (en) 2004-11-05 2010-11-02 Icu Medical, Inc. Medical connector having high flow rate characteristics
US20060271016A1 (en) * 2004-11-05 2006-11-30 Fangrow Thomas F Soft-grip medical connector
US20060211998A1 (en) * 2004-11-05 2006-09-21 Fangrow Thomas F Soft-grip medical connector
US20060161115A1 (en) * 2004-11-05 2006-07-20 Fangrow Thomas F Soft-grip medical connector
US20060270999A1 (en) * 2004-11-05 2006-11-30 Fangrow Thomas F Soft-grip medical connector
US9884176B2 (en) 2004-11-05 2018-02-06 Icu Medical, Inc. Medical connector
US20070167910A1 (en) * 2005-11-09 2007-07-19 Hyprotek, Inc. Syringe Devices, Components of Syringe Devices, and Methods of Forming Components and Syringe Devices
US8608686B2 (en) 2005-11-09 2013-12-17 Hyprotek, Inc. Syringe devices, components of syringe devices, and methods of forming components and syringe devices
US10485930B2 (en) 2005-11-09 2019-11-26 Hyprotek, Inc. Syringe devices, components of syringe devices, and methods of forming components and syringe devices
US8137307B2 (en) 2005-11-09 2012-03-20 Hyprotek, Inc. Syringe devices, components of syringe devices, and methods of forming components and syringe devices
US10631906B2 (en) 2005-11-22 2020-04-28 DePuy Synthes Products, Inc. Apparatus for transferring a viscous material
US10494158B2 (en) * 2006-10-19 2019-12-03 DePuy Synthes Products, Inc. Fluid delivery system
US8628515B2 (en) 2006-10-25 2014-01-14 Icu Medical, Inc. Medical connector
US9533137B2 (en) 2006-10-25 2017-01-03 Icu Medical, Inc. Medical connector
US8398607B2 (en) 2006-10-25 2013-03-19 Icu Medical, Inc. Medical connector
US8105314B2 (en) 2006-10-25 2012-01-31 Icu Medical, Inc. Medical connector
US8512278B2 (en) 2007-10-04 2013-08-20 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US9522097B2 (en) 2007-10-04 2016-12-20 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US10524983B2 (en) 2007-10-04 2020-01-07 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US8002737B2 (en) 2007-10-04 2011-08-23 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US9555180B2 (en) 2008-11-21 2017-01-31 Baxter International Inc. Systems and methods for removing air from the patient's peritoneal cavity
US20100130918A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from supply containers and associated fill tubing
US20100130919A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from the patient's peritoneal cavity
US10086188B2 (en) 2009-03-25 2018-10-02 Icu Medical, Inc. Medical connectors and methods of use
US11376411B2 (en) 2009-03-25 2022-07-05 Icu Medical, Inc. Medical connectors and methods of use
US11931539B2 (en) 2009-03-25 2024-03-19 Icu Medical, Inc. Medical connectors and methods of use
US8454579B2 (en) 2009-03-25 2013-06-04 Icu Medical, Inc. Medical connector with automatic valves and volume regulator
US10799692B2 (en) 2009-03-25 2020-10-13 Icu Medical, Inc. Medical connectors and methods of use
US10391293B2 (en) 2009-03-25 2019-08-27 Icu Medical, Inc. Medical connectors and methods of use
US11896795B2 (en) 2009-03-25 2024-02-13 Icu Medical, Inc Medical connector having elongated portion within closely conforming seal collar
US9278206B2 (en) 2009-03-25 2016-03-08 Icu Medical, Inc. Medical connectors and methods of use
US9440060B2 (en) 2009-03-25 2016-09-13 Icu Medical, Inc. Medical connectors and methods of use
USD644731S1 (en) 2010-03-23 2011-09-06 Icu Medical, Inc. Medical connector
USD1003434S1 (en) 2010-03-23 2023-10-31 Icu Medical, Inc. Medical connector seal
US9192753B2 (en) 2010-05-17 2015-11-24 Icu Medical, Inc. Medical connectors and methods of use
US9750926B2 (en) 2010-05-17 2017-09-05 Icu Medical, Inc. Medical connectors and methods of use
US8758306B2 (en) 2010-05-17 2014-06-24 Icu Medical, Inc. Medical connectors and methods of use
US9205243B2 (en) 2010-05-17 2015-12-08 Icu Medical, Inc. Medical connectors and methods of use
US10195413B2 (en) 2010-05-17 2019-02-05 Icu Medical, Inc. Medical connectors and methods of use
US11071852B2 (en) 2010-05-17 2021-07-27 Icu Medical, Inc. Medical connectors and methods of use
US11364372B2 (en) 2013-12-11 2022-06-21 Icu Medical, Inc. Check valve
US10369349B2 (en) 2013-12-11 2019-08-06 Icu Medical, Inc. Medical fluid manifold
USD890335S1 (en) 2014-12-03 2020-07-14 Icu Medical, Inc. Fluid manifold
USD826400S1 (en) 2014-12-03 2018-08-21 Icu Medical, Inc. Fluid manifold
USD793551S1 (en) 2014-12-03 2017-08-01 Icu Medical, Inc. Fluid manifold
USD786427S1 (en) 2014-12-03 2017-05-09 Icu Medical, Inc. Fluid manifold
USD849939S1 (en) 2014-12-03 2019-05-28 Icu Medical, Inc. Fluid manifold
US11213631B2 (en) 2017-06-13 2022-01-04 Difinity Solutions Inc. Protected needle assembly for a hypodermic needle
US11759570B2 (en) 2019-02-25 2023-09-19 Difinity Solutions Inc. Medicament injector and interchangeable cartridges therefor

Similar Documents

Publication Publication Date Title
US3659602A (en) Two component syringe
US6638244B1 (en) Delivery system for multi-component pharmaceuticals
EP0817654B1 (en) Pre-filled syringe drug delivery system
US3884229A (en) Hypodermic syringe and needle assembly
US5637087A (en) Prefilled, two-constituent syringe
CA2123601C (en) Syringe
US7736353B2 (en) Pharmaceutical delivery systems and methods for using same
US6840291B2 (en) Attachment for a medical device
US4172457A (en) Plural component mixing system and method
US4226236A (en) Prefilled, vented two-compartment syringe
US4153057A (en) Stopper for two-chamber mixing syringe
US4180070A (en) Disposable double vial syringe
US3958570A (en) Syringes and syringe capsules
US4333456A (en) Self-aspirating hypodermic syringe and self-aspirating assembly therefor
US4048999A (en) Two-chamber mixing syringe
AU1757988A (en) Syringe
US20020087118A1 (en) Pharmaceutical delivery system
US5489267A (en) Double chamber disposable syringe
US3066671A (en) Disposable additive container
GB1089608A (en) Container
AU629385B2 (en) Bipartite injector device
GB2249727A (en) Syringe vial
US3125092A (en) Infusion flask
WO1981000211A1 (en) Syringe with inner cone
CN215741008U (en) Self-destruction syringe