US3732734A - Micropipette with disposable tips - Google Patents

Micropipette with disposable tips Download PDF

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US3732734A
US3732734A US00256992A US3732734DA US3732734A US 3732734 A US3732734 A US 3732734A US 00256992 A US00256992 A US 00256992A US 3732734D A US3732734D A US 3732734DA US 3732734 A US3732734 A US 3732734A
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ribs
ringed
tip member
open end
annular
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US00256992A
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S Avakian
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Centaur Chemical Co
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Centaur Chemical Co
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips

Definitions

  • ABSTRACT A spring loaded plunger actuated vacuum pipette tube is disclosed for use in combination with removable disposable molded plastic tip members wherein a plurality of adjacent concentric internal annular rings are formed within the larger open end of the tip member, and annular rings being of successively decreasing diameter progressing inwardly, for cooperative airtight frictional engagement with a smoothly tapered end surface of the pipette tube.
  • the present invention is directed to improved disposable pipette tips, formed of injection molded plastic material, such as polyethylene, which are functional for a wide range of applications and are impervious to acids, alkalies and most organic solvents, and have nonwetting characteristics.
  • the tips are easily and quickly inserted on the end of a pipette tube with which they form an airtight seal, and are just as easily and quickly removable therefrom for disposal after use. Because of their low cost the plastic tips of the invention may be discarded after each use, thus eliminating the need for washing and sterilization for the next operation.
  • a quantity of tips may be stored in a sanitary jig or fixture from which individual tips may be easily picked up by simply inserting the end of a pipette tube, and they may be subsequently removed from the instrument simply by pressing the external shoulder against the lip of a disposal container all in a single handed operation.
  • An overall object of the invention is to provide such a micropipette which affords maximum convenience, cleanliness, ease of operation and the elimination of cross-contamination.
  • the invention accordingly comprises an article of manufacture possessing the features, properties, and the relation of elements which will be exemplified in the article hereinafter described, and the scope of the invention will be indicated in the claims.
  • FIG. I is a horizontal view, partially cut away, ofa pipette instrument with a disposable tip member mounted on the vacuum end thereof;
  • FIG. 2 is an enlarged view of the tip member mounted on the instrument end, and shown partially in section substantially along the line 2-2 of FIG. 1;
  • FIG. 3 is a cross-sectional view of the large end of the tip member taken along the line 3-3 of FIG. 2;
  • FIG. 4 is a greatly enlarged cross-sectional view of the large end portion of the tip member of the invention showing the manner in which the concentric internal annular ringed rib portions decrease in diameter inwardly to provide effective airtight sealing means for the pipette tube.
  • a preferred embodiment of the invention includes a vacuum pipette instrument indicated generally at 5, having (from right to left) a finger operated plunger 6 axially mounted within an annular finger grip 7 which is affixed to one end of a hollow cylindrical tube 8. Affixed to and coaxial with the opposite end of cylinder 8 is a reduced diameter elongated hollow nozzle portion 9, the end of which is tapered as may be seen more clearly in FIG. 2.
  • a spring loaded air pump piston 10 which is operable by depression and release of plunger 6 to produce a controlled stroke, measured volume air displacement.
  • An airtight axial valve formed between the internal central rod 11 and a valve seat formed in coaxial bushing 12 is opened when the plunger 6 is depressed and is closed when plunger 6 is fully released.
  • an elongated hollow tapered tip member 14 which is preferably formed as a right circular cone, has its larger open end fitted over the tapered end of nozzle 9 on the plunger instrument 5.
  • tip member 14 The opposite end 16 of tip member 14 is provided with a small diameter coaxial opening through which controlled amounts of fluid may be admitted and discharged when the tip end 16 is immersed in sample liquids or reagents and the plunger 6 is depressed.
  • the device of FIG. 1 including the pump instrument 5 with tip member 14 affixed as shown, is held in a gener ally vertical position by one hand, with two fingers under the annular grip 7 and a thumb or forefinger resting on plunger 6 in a position for depressing the plunger at will.
  • the plunger 6 is then depressed, the tip 16 is immersed in the liquid to be sampled, and the plunger 6 is then released, thereby drawing an accurately measured volume of liquid into the lower end of tip member 14.
  • the tip member 14 may be easily removed from the nozzle 9 by a simple wiping motion, as achieved by placing the annular shoulder portion 17 against the inner lip of an open refuse container and merely pulling backward (from left to right in FIG. I) on the annular finger grip 7. A fresh unused tip may then be easily picked up simply by inserting the tapered end of nozzle 9 into the open end of a new tip member, which may be conveniently held either by hand or in a table top fixture rack.
  • FIG. 2 is an enlarged view of the left-hand portion of FIG. 1 with the tip member 14 foreshortened at 13 to conserve drawing space and the right half of member 14 cut away in section to show the internal cavity 20, the tapered end surface 18 of nozzle 9 may be seen inserted into frictional engagement with a plurality of inner annular ring ribbed portions 19 formed on the inner open end 15 of tip member 14.
  • the tip member 15 is formed of injection molded plastic material, such as polyethylene
  • the annular ribs 19 are semiflexible and compressible and thus provide a mechanically rigid airtight seal with the tapered metallic surface 18 of nozzle 9.
  • FIG. 3 being a cross-sectional view taken along the line 33 of FIG. 2, further illustrates the cooperative engagement of collar end 15 of tip member 14 surrounding the tapered surface 18 of hollow nozzle 9.
  • FIG. 4 is a greatly enlarged cross-sectional view of the right-hand end portion of tip member 14 as shown in FIG. 2, the plurality of inner annular ringed ribs indicated generally as 19 in FIG. 2 are shown separately as 21 through 25. From this figure it may be seen that the annular ribs 21-25 decrease in diameter inwardly from 25 to 21; i.e., the inner diameter of 25 is greater than that of 24, which in turn is greater than 23, etc. Significantly, a line drawn tangent to the inner annular surfaces of ribbed rings 21-25 forms a greater angle with the horizontal (in FIG. 4) than does the taper 18 of nozzle 9 in FIG. 2.
  • a detachable and disposable tip member formed of molded plastic in a substantial right cylinder elongated hollow cone, having an outer annular ring portion formed around its larger open end and at least one elastically deformable annular inner ringed rib formed within said larger open end and concentric with the axis of said cone.

Abstract

A spring loaded plunger actuated vacuum pipette tube is disclosed for use in combination with removable disposable molded plastic tip members wherein a plurality of adjacent concentric internal annular rings are formed within the larger open end of the tip member, and annular rings being of successively decreasing diameter progressing inwardly, for cooperative airtight frictional engagement with a smoothly tapered end surface of the pipette tube. The foregoing abstract is not to be taken either as a complete exposition or as a limitation of the present invention. In order to understand the full nature and extent of the technical disclosure of this application, reference must be had to the following detailed description and the accompanying drawing as well as to the claims.

Description

United States Patent 1 1 Avakian 1 1 May 15,1973
1541 MICROPIPETTE WITH DISPOSABLE TIPS [75] Inventor: Souren Avakian, Westport, Conn.
[73] Assignee: Centaur Chemical Co., Danbury,
Conn.
22 Filed: May25, 1972 21 Appl.No.: 256,992
[52] U.S.Cl. ..73/425.6, l4l/3ll,285/239 [51] Int. Cl. ..B0ll 3/02 [58] Field of Search ..73/425.4 P, 425.6; 141/18, 31, 311; 285/238, 239, 240, 260, 8;
[56] References Cited UNITED STATES PATENTS 3,498,135 3/1970 Seitz ..23/292 3,471,179 10/1969 Sixt ..285/260 2,525,419 10/1950 Mellinger... .....285/8 2,699,357 1/1955 Roth ..285/8 Primary ExaminerS. Clement Swisher Armmey- Robert A. Buckles [5 7] ABSTRACT A spring loaded plunger actuated vacuum pipette tube is disclosed for use in combination with removable disposable molded plastic tip members wherein a plurality of adjacent concentric internal annular rings are formed within the larger open end of the tip member, and annular rings being of successively decreasing diameter progressing inwardly, for cooperative airtight frictional engagement with a smoothly tapered end surface of the pipette tube.
The foregoing abstract is not to be taken either as a complete exposition or as a limitation of the present invention. In order to understand the full nature and extent of the technical disclosure of this application, reference must be had to the following detailed description and the accompanying drawing as well as to the claims.
6 Claims, 4 Drawing Figures BACKGROUND OF THE INVENTION In busy chemical and pharmaceutical laboratories, for the expeditious performance of numerous analytical tests it is necessary to quickly and accurately measure and deliver micro volumes of various reagents and samples for analysis. For this purpose various vacuum pipettes have been developed in the prior art.
The present invention is directed to improved disposable pipette tips, formed of injection molded plastic material, such as polyethylene, which are functional for a wide range of applications and are impervious to acids, alkalies and most organic solvents, and have nonwetting characteristics. The tips are easily and quickly inserted on the end of a pipette tube with which they form an airtight seal, and are just as easily and quickly removable therefrom for disposal after use. Because of their low cost the plastic tips of the invention may be discarded after each use, thus eliminating the need for washing and sterilization for the next operation. By reason of an external annular shoulder formed around the larger open end of each tip a quantity of tips may be stored in a sanitary jig or fixture from which individual tips may be easily picked up by simply inserting the end of a pipette tube, and they may be subsequently removed from the instrument simply by pressing the external shoulder against the lip of a disposal container all in a single handed operation.
OBJECTS OF THE INVENTION It is an object of the invention to provide an inexpensive disposable micropipette capable of easy and convenient one-hand operation without need for or risk of the operators hand touching any part which comes in contact with chemical reagents.
It is a further object to provide such a pipette which is impervious to acids, alkalies and organic solvents.
An overall object of the invention is to provide such a micropipette which affords maximum convenience, cleanliness, ease of operation and the elimination of cross-contamination.
Other objects of the invention will in part be obvious from the following description and the claims.
The invention accordingly comprises an article of manufacture possessing the features, properties, and the relation of elements which will be exemplified in the article hereinafter described, and the scope of the invention will be indicated in the claims.
BRIEF DESCRIPTION OF THE DRAWING For a fuller understanding of the nature and objects of the invention, reference should be had to the following detailed description taken in connection with the accompanying drawing, in which:
FIG. I is a horizontal view, partially cut away, ofa pipette instrument with a disposable tip member mounted on the vacuum end thereof;
FIG. 2 is an enlarged view of the tip member mounted on the instrument end, and shown partially in section substantially along the line 2-2 of FIG. 1;
FIG. 3 is a cross-sectional view of the large end of the tip member taken along the line 3-3 of FIG. 2; and
FIG. 4 is a greatly enlarged cross-sectional view of the large end portion of the tip member of the invention showing the manner in which the concentric internal annular ringed rib portions decrease in diameter inwardly to provide effective airtight sealing means for the pipette tube.
DETAILED DESCRIPTION Referring now in greater detail to FIG. 1 of the drawing, a preferred embodiment of the invention includes a vacuum pipette instrument indicated generally at 5, having (from right to left) a finger operated plunger 6 axially mounted within an annular finger grip 7 which is affixed to one end of a hollow cylindrical tube 8. Affixed to and coaxial with the opposite end of cylinder 8 is a reduced diameter elongated hollow nozzle portion 9, the end of which is tapered as may be seen more clearly in FIG. 2.
Still referring to FIG. 1, within the hollow cylindrical tube 8 is a spring loaded air pump piston 10 which is operable by depression and release of plunger 6 to produce a controlled stroke, measured volume air displacement. An airtight axial valve formed between the internal central rod 11 and a valve seat formed in coaxial bushing 12 is opened when the plunger 6 is depressed and is closed when plunger 6 is fully released. As shown to the left in FIG. 1 an elongated hollow tapered tip member 14, which is preferably formed as a right circular cone, has its larger open end fitted over the tapered end of nozzle 9 on the plunger instrument 5. The opposite end 16 of tip member 14 is provided with a small diameter coaxial opening through which controlled amounts of fluid may be admitted and discharged when the tip end 16 is immersed in sample liquids or reagents and the plunger 6 is depressed. In use the device of FIG. 1, including the pump instrument 5 with tip member 14 affixed as shown, is held in a gener ally vertical position by one hand, with two fingers under the annular grip 7 and a thumb or forefinger resting on plunger 6 in a position for depressing the plunger at will. The plunger 6 is then depressed, the tip 16 is immersed in the liquid to be sampled, and the plunger 6 is then released, thereby drawing an accurately measured volume of liquid into the lower end of tip member 14. Because of the closure of the airtight valve 11-12 upon release of plunger 6 the liquid drawn into a tip member 14 remains therein, under the force of external atmospheric pressure, until such time as the plunger 6 is again depressed to expel the sample fluid from the small end opening at 16. Because the total internal volume of the conical tip member 14 greatly exceeds the accurately measured volumetric displacement of plunger 10 within cylinder 8, the sample fluid within the tip 14 never rises far enough to contaminate (or be contaminated by) the nozzle 9 of instrument 5. After discharge of the measured sample from tip 14, the tip member may be easily removed from the nozzle 9 by a simple wiping motion, as achieved by placing the annular shoulder portion 17 against the inner lip of an open refuse container and merely pulling backward (from left to right in FIG. I) on the annular finger grip 7. A fresh unused tip may then be easily picked up simply by inserting the tapered end of nozzle 9 into the open end of a new tip member, which may be conveniently held either by hand or in a table top fixture rack.
The salient feature which facilitates the airtight engagement of the tip members such as 14 with the instrument nozzle 9, and the ease of application and removal therefrom as described above, will now be described in detail with reference to FIGS. 2 through 4 of the drawmg.
Referring first to FIG. 2, which is an enlarged view of the left-hand portion of FIG. 1 with the tip member 14 foreshortened at 13 to conserve drawing space and the right half of member 14 cut away in section to show the internal cavity 20, the tapered end surface 18 of nozzle 9 may be seen inserted into frictional engagement with a plurality of inner annular ring ribbed portions 19 formed on the inner open end 15 of tip member 14. As the tip member 15 is formed of injection molded plastic material, such as polyethylene, the annular ribs 19 are semiflexible and compressible and thus provide a mechanically rigid airtight seal with the tapered metallic surface 18 of nozzle 9.
FIG. 3, being a cross-sectional view taken along the line 33 of FIG. 2, further illustrates the cooperative engagement of collar end 15 of tip member 14 surrounding the tapered surface 18 of hollow nozzle 9.
Referring now to FIG. 4, which is a greatly enlarged cross-sectional view of the right-hand end portion of tip member 14 as shown in FIG. 2, the plurality of inner annular ringed ribs indicated generally as 19 in FIG. 2 are shown separately as 21 through 25. From this figure it may be seen that the annular ribs 21-25 decrease in diameter inwardly from 25 to 21; i.e., the inner diameter of 25 is greater than that of 24, which in turn is greater than 23, etc. Significantly, a line drawn tangent to the inner annular surfaces of ribbed rings 21-25 forms a greater angle with the horizontal (in FIG. 4) than does the taper 18 of nozzle 9 in FIG. 2. Thus, when the tapered end of nozzle 9 is inserted into the larger open end of tip member 14, the surface 18 first engages outer annular rib 25; as the nozzle 9 is protruded further into tip 14 the surface 18 successively becomes frictionally engaged with annular ribs 24, 23, etc., compressing each rib further as it is inserted farther, thereby establishing both a mechanical coupling and an airtight seal between tip member 14 and instrument 5.
It will thus be seen that the objects set forth above, among those made apparent from the preceding description, are efficiently attained and, since certain changes may be made in the above article without departing from the scope of the invention, it is intended that all matter contained in the above description or shown in the accompanying drawing shall be interpreted as illustrative and not in a limiting sense.
It is also to be understood that the following claims are intended to cover all of the generic and specific features of the invention which, as a matter of language, might be said to fall therebetween.
Having described my invention, what I claim as new and desire to secure by Letters Patent is:
l. The combination of a spring loaded plunger actuated vacuum pipette and a removable disposable plastic tip member comprising a taper formed on the end of the pipette opposite the plunger thereof, and a plurality of adjacent concentric internal ringed ribs of successively decreasing diameter formed on the inner surface of an open end of said plastic tip member, whereby said ringed ribs frictionally engage said tapered end to form an airproof seal therebetween.
2. The combination of claim 1 wherein the taper formed on the end of said pipette is less than the taper formed between the inner surfaces of the innermost and outermost of said successive internal ringed ribs.
3. The combination of claim 1 and an outer annular shoulder portion formed on the outer open end of said tip member adjacent to and surrounding said concentric ringed ribs.
4. For use with a spring loaded plunger actuated vacuum pipette instrument, a detachable and disposable tip member formed of molded plastic in a substantial right cylinder elongated hollow cone, having an outer annular ring portion formed around its larger open end and at least one elastically deformable annular inner ringed rib formed within said larger open end and concentric with the axis of said cone.
5. The combination of claim 4 including a plurality of adjacent annular ringed ribs formed on the inner conical surface of said tip member within the larger open end thereof, said annular ringed ribs being of progressively decreasing diameter inwardly from said openv end.
6. The combination of claim 5 wherein the diameters of said adjacent annular ringed ribs decreases progressively in such manner that a conical surface tangential to the inner surfaces of all said annular ribs forms a greater taper than that of a pipette instrument adapted for insertion therein.

Claims (6)

1. The combination of a spring loaded plunger actuated vacuum pipette and a removable disposable plastic tip member comprising a taper formed on the end of the pipette opposite the plunger thereof, and a plurality of adjacent concentric internal ringed ribs of successively decreasing diameter formed on the inner surface of an open end of said plastic tip member, whereby said ringed ribs frictionally engage said tapered end to form an airproof seal therebetween.
2. The combination of claim 1 wherein the taper formed on the end of said pipette is less than the taper formed between the inner surfaces of the innermost and outermost of said successive internal ringed ribs.
3. The combination of claim 1 and an outer annular shoulder portion formed on the outer open end of said tip member adjacent to and surrounding said concentric ringed ribs.
4. For use with a spring loaded plunger actuated vacuum pipette instrument, a detachable and disposable tip member formed of molded plastic in a substantial right cylinder elongated hollow cone, having an outer annular ring portion formed around its larger open end and at least one elastically deformable annular inner ringed rib formed within said larger open end and concentric with the axis of said cone.
5. The combinatiOn of claim 4 including a plurality of adjacent annular ringed ribs formed on the inner conical surface of said tip member within the larger open end thereof, said annular ringed ribs being of progressively decreasing diameter inwardly from said open end.
6. The combination of claim 5 wherein the diameters of said adjacent annular ringed ribs decreases progressively in such manner that a conical surface tangential to the inner surfaces of all said annular ribs forms a greater taper than that of a pipette instrument adapted for insertion therein.
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Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995496A (en) * 1975-09-02 1976-12-07 Bickford Albert G Disposable mouth guard for pipettes
US4072330A (en) * 1975-06-12 1978-02-07 Eppendorf Geratebau Netheler & Hinz Gmbh Slip-on pipette tip member and pipette device therefor
US4112762A (en) * 1976-04-28 1978-09-12 Johnson & Johnson Probe cover grip and release device
US4187724A (en) * 1978-01-11 1980-02-12 Indicon Inc. Replaceable tip for a pipette
WO1981001666A1 (en) * 1979-12-10 1981-06-25 Indicon Inc Replaceable tip for a pipette
FR2489507A1 (en) * 1980-08-27 1982-03-05 Hettich Andreas Doser pipette for liquids - using push-button to actuate piston which forces specific vol. of liq. out of pipette tip (SE 8.3.82)
US4347875A (en) * 1980-07-14 1982-09-07 Eastman Kodak Company Self-cleaning nozzle construction for aspirators
US4567926A (en) * 1984-01-09 1986-02-04 Carb-A-Drink International, Inc. Apparatus for and method of dispensing bulk liquids
US4590974A (en) * 1983-12-22 1986-05-27 Carb-A-Drink International, Inc. Beverage dispenser
US4748859A (en) * 1987-03-06 1988-06-07 Rainin Instrument Co., Inc. Disposable pipette tip
US4824641A (en) * 1986-06-20 1989-04-25 Cetus Corporation Carousel and tip
US4961350A (en) * 1988-07-21 1990-10-09 Firma Eppendorf-Netheler-Hinz Gmbh Fittable pipette tip consisting of a vessel which is designed to fit a particularly conical fitting head of a pipette
US5226600A (en) * 1991-08-02 1993-07-13 Wagner Spray Tech Corporation Check valve
US5272926A (en) * 1991-11-13 1993-12-28 Wilkins Judd R Microbial retrieval and sampling pipette with a removable cover
US5440940A (en) * 1994-03-18 1995-08-15 Wilkins; Judd R. Pipette-syringe-tubular microbial retrieval and sampler
US6168761B1 (en) * 1998-11-06 2001-01-02 Rainin Instrument Co., Inc. Pipette with improved pipette tip and mounting shaft
WO2002055200A1 (en) * 2001-01-12 2002-07-18 Porex Corporation Pipette tip for easy mounting and ejecting from a pipette
US6550349B1 (en) * 2000-09-19 2003-04-22 Molecular Devices Corporation Pipette tip holder
WO2003086632A1 (en) * 2002-04-08 2003-10-23 Yiu Felix H Improved pipettor and externally sealed pipette tips
US20030223910A1 (en) * 2002-02-12 2003-12-04 Molecular Devices Corp. Pipettor systems and components
US20040141885A1 (en) * 2002-02-12 2004-07-22 Molecular Devices Corp. Pipettor systems and components
US6780381B2 (en) 2002-04-08 2004-08-24 Felix H. Yiu Pipettor and externally sealed pipette tip
US20050175511A1 (en) * 2004-02-11 2005-08-11 Cote Richard A. Pipette tip mounting and ejection assembly and associated pipette tip
US20050287327A1 (en) * 2004-06-29 2005-12-29 Kazuo Ishikawa Anticorrosion sleeve
US7033543B1 (en) * 1999-04-16 2006-04-25 Hamilton Bonaduz Ag Pipette tip, pipetting device and combination consisting of a pipette tip and pipetting device
US20090286326A1 (en) * 2005-12-20 2009-11-19 Caldwell Jeremy S Tool for Extracting Electrophoretic Sample
US20090317303A1 (en) * 2008-06-24 2009-12-24 Roche Molecular Systems, Inc. Flexible disposable tip interface
US20100083773A1 (en) * 2008-10-04 2010-04-08 Eppendorf Ag Sample carrier
US8480015B1 (en) * 1999-01-26 2013-07-09 Dl Technology, Llc Fluid dispense tips
US8690084B1 (en) * 2000-01-26 2014-04-08 Dl Technology Llc Fluid dispense tips
US8707559B1 (en) 2007-02-20 2014-04-29 Dl Technology, Llc Material dispense tips and methods for manufacturing the same
US8864055B2 (en) 2009-05-01 2014-10-21 Dl Technology, Llc Material dispense tips and methods for forming the same
EP3115110A1 (en) * 2015-07-07 2017-01-11 Eppendorf Ag Pipette tips
US20170361316A1 (en) * 2016-06-15 2017-12-21 Hamilton Company Pipetting Device, Pipette Tip Coupler, and Pipette Tip: Devices and Methods
US10898892B2 (en) 2016-06-15 2021-01-26 Hamilton Company Pipetting device, pipette tip coupler, and pipette tip: devices and methods
US11065614B2 (en) 2016-06-15 2021-07-20 Hamilton Company Pipetting device, pipette tip coupler, and pipette tip: devices and methods
US11235318B2 (en) 2016-06-15 2022-02-01 Hamilton Company Pipetting device, pipette tip coupler, and pipette tip: devices and methods
US11370596B1 (en) 2012-02-24 2022-06-28 DL Technology, LLC. Micro-volume dispense pump systems and methods
US11746656B1 (en) 2019-05-13 2023-09-05 DL Technology, LLC. Micro-volume dispense pump systems and methods

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US2525419A (en) * 1949-02-21 1950-10-10 Edward R Mcllinger Syringe
US2699357A (en) * 1950-08-04 1955-01-11 Charles M Roth Faucet attachment for bubble bath
US3471179A (en) * 1967-12-26 1969-10-07 Advanced Drainage Syst Adapter
US3498135A (en) * 1968-11-13 1970-03-03 Baxter Laboratories Inc Pipette

Cited By (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072330A (en) * 1975-06-12 1978-02-07 Eppendorf Geratebau Netheler & Hinz Gmbh Slip-on pipette tip member and pipette device therefor
US3995496A (en) * 1975-09-02 1976-12-07 Bickford Albert G Disposable mouth guard for pipettes
US4112762A (en) * 1976-04-28 1978-09-12 Johnson & Johnson Probe cover grip and release device
US4187724A (en) * 1978-01-11 1980-02-12 Indicon Inc. Replaceable tip for a pipette
WO1981001666A1 (en) * 1979-12-10 1981-06-25 Indicon Inc Replaceable tip for a pipette
US4347875A (en) * 1980-07-14 1982-09-07 Eastman Kodak Company Self-cleaning nozzle construction for aspirators
FR2489507A1 (en) * 1980-08-27 1982-03-05 Hettich Andreas Doser pipette for liquids - using push-button to actuate piston which forces specific vol. of liq. out of pipette tip (SE 8.3.82)
US4590974A (en) * 1983-12-22 1986-05-27 Carb-A-Drink International, Inc. Beverage dispenser
US4567926A (en) * 1984-01-09 1986-02-04 Carb-A-Drink International, Inc. Apparatus for and method of dispensing bulk liquids
US4824641A (en) * 1986-06-20 1989-04-25 Cetus Corporation Carousel and tip
US4748859A (en) * 1987-03-06 1988-06-07 Rainin Instrument Co., Inc. Disposable pipette tip
US4961350A (en) * 1988-07-21 1990-10-09 Firma Eppendorf-Netheler-Hinz Gmbh Fittable pipette tip consisting of a vessel which is designed to fit a particularly conical fitting head of a pipette
US5226600A (en) * 1991-08-02 1993-07-13 Wagner Spray Tech Corporation Check valve
US5272926A (en) * 1991-11-13 1993-12-28 Wilkins Judd R Microbial retrieval and sampling pipette with a removable cover
US5360721A (en) * 1991-11-13 1994-11-01 Wilkins Judd R Microbial retrieval and sampling method
US5440940A (en) * 1994-03-18 1995-08-15 Wilkins; Judd R. Pipette-syringe-tubular microbial retrieval and sampler
US6168761B1 (en) * 1998-11-06 2001-01-02 Rainin Instrument Co., Inc. Pipette with improved pipette tip and mounting shaft
US6171553B1 (en) * 1998-11-06 2001-01-09 Rainin Instrument Co., Inc. Pipette with improved pipette tip and mounting shaft
US8480015B1 (en) * 1999-01-26 2013-07-09 Dl Technology, Llc Fluid dispense tips
US7033543B1 (en) * 1999-04-16 2006-04-25 Hamilton Bonaduz Ag Pipette tip, pipetting device and combination consisting of a pipette tip and pipetting device
US9573156B1 (en) 2000-01-26 2017-02-21 Dl Technology, Llc Fluid dispense tips
US8690084B1 (en) * 2000-01-26 2014-04-08 Dl Technology Llc Fluid dispense tips
US9242770B2 (en) 2000-01-26 2016-01-26 Dl Technology, Llc Fluid dispense tips
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