US3858580A - Intravenous container mixing assembly - Google Patents

Intravenous container mixing assembly Download PDF

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US3858580A
US3858580A US30278372A US3858580A US 3858580 A US3858580 A US 3858580A US 30278372 A US30278372 A US 30278372A US 3858580 A US3858580 A US 3858580A
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Prior art keywords
vial
spike
fluid
drip meter
base
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Robert W Ogle
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IMS HOLDINGS A CORP OF
International Medication Systems Ltd
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IMS Ltd
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Priority to US05302783 priority Critical patent/US3858580A/en
Priority to CA161,659A priority patent/CA1001513A/en
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Publication of US3858580A publication Critical patent/US3858580A/en
Priority to US05/587,151 priority patent/USRE29062E/en
Assigned to INTERNATIONAL MEDICATION SYSTEMS, LIMITED reassignment INTERNATIONAL MEDICATION SYSTEMS, LIMITED MERGER (SEE DOCUMENT FOR DETAILS). Assignors: DLG HOLDING CORP. A CORP. OF DE, IMS HOLDINGS A CORP. OF CA
Assigned to IMS HOLDINGS A CORP. OF CA reassignment IMS HOLDINGS A CORP. OF CA MERGER (SEE DOCUMENT FOR DETAILS). AUGUST 25, 1988, DE Assignors: IMS, LTD.
Assigned to GLENFED CAPITAL CORP., A CA CORP. reassignment GLENFED CAPITAL CORP., A CA CORP. AMENDMENT TO SECURITY AGREEMENT DATED 7/15/88. Assignors: INTERNATIONAL MEDICATION SYSTEMS, LIMITED
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Assigned to INTERNATIONAL MEDICATION SYSTEMS, LIMITED, A CORP. OF DE reassignment INTERNATIONAL MEDICATION SYSTEMS, LIMITED, A CORP. OF DE SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GLENFED CAPITAL CORP., A CORP. OF CA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2041—Separating means having removable plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A61M2005/1623—Details of air intake

Definitions

  • ABSTRACT A device for the mixing and administration of intravekat fluid comprising a cylindrical vial having an open end and a closed end, an inwardly extending integral annular ring within the vial and forming part of the walls of the vial intermediate said open and closed ends. A tippable center septum seals on the annular ring. An imperforate stopper is provided in the open end of the vial.
  • the vial is adapted to contain two liquids or a liquid and a dry material in separated state.
  • a non-opaque drip meter having a fluid outlet at one end and a fluid inlet is provided, the inlet comprising a tubular member terminating within the drip meter whereby drops can be visually observed at the end of the tubular member through the drip meter.
  • Extending from the drip meter is a solid or hollow elongated rigid spike having an enlarged base adjacent the drip meter, the spike terminating in a point at its other end.
  • a filtered air inlet is positioned in proximity to the base of the spike, a passage and filter are associated with the spike or base for admitting filtered air into the vial.
  • a fluid passage runs through the base and has one end adjacent the spike at the exterior of the base and the other end communicates with the tubular member. The spike is adapted to puncture the stopper and tip the septum whereby the contents of the vial can be mixed without contamination from the exterior and the fluid contents of the vial can flow through the fluid passage and the drip meter while filtered air passes into the vial.
  • the present invention is basically concerned with eliminating these problems and hazards by providing a closed system in which the solid medicament and its diluent can be packaged under strict sterile conditions at the factory, and reconstituted at the time of use without the necessity of the medicament becoming contaminated during a transfer operation. It is the art of administering intravenous solutions.
  • this invention comprises a novel device for the mixing and administration of intravenous fluid comprising a cylindrical vial having an open end and a closed end, an inwardly extending integral annular ring within said vial and forming part of the walls of said vial intermediate said open and closed ends, a tippable center septum sealing on said annular ring, an imperforate stopper in said open end, said vial being adapted to contain two liquids or a liquid and a dry material in separated state, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter a solid or hollow elongated rigid spike having an enlarged base adjacent said drip meter, said spike terminating in a point at its other end, a filtered air inlet positioned in proximity to the base of said spike, means
  • Another object of this invention is to provide a novel device for the packaging and administration of medicament for intravenous use which during storage is maintained in separated condition, viz, two liquids or a liquid and a dry material.
  • FIG. 1 shows one embodiment of the drip meter and spike of this invention.
  • FIG. 2 is a top viewof the device of FIG. 1.
  • FIG. 3 is a bottom view of the device of FIG. 1.
  • FIG. 4 shows, in side sectional view, one embodiment of the vial, center septum and end stopper of this invention.
  • FIG. 5 is a plan view of the end stopper of the vial of FIG. 4.
  • FIG. 6 shows, in sectional view, the parts of FIGS. 1-5 in partially assembled condition.
  • FIG. 7 is a sectional view of the parts of FIG. 1-5 in fully assembled condition.
  • FIG. 8 is a sectional view of another embodiment of this invention.
  • the cylindrical vial 10 has an open end 12 and a closed end 14.
  • the center septum 16 is positioned just above and abuts the integral annular ring 18.
  • chamber 20 which contains a dry or lyophilized medicament 22.
  • the septum 16 has four sealing rings 24, 26, 28 and 30 which form a seal on the inside walls of the vial 10.
  • a chamber 32 for liquid or diluent 34 is provided between septum 16 and the end stopper 36.
  • the end stopper 36 unlike septum I6, is non-reciprocating; that is, it is not slidable downwardly within vial 10, such movement being prevented by shoulders 38 which overlay and may seal upon the ends of vial10.
  • the drip meter 40 has an outlet 42 provided with tubing 44 normally intended to carry the intravenous solution to the patient in conventional fashion.
  • the drip meter 40 is normally non-opaque; that is, transparent or translucent so that drops of fluid may be observed and/or counted.
  • the drip meter 40 has a fluid inlet comprising a tubular member 46 which terminates within the non-opaque drip meter.
  • the rigid spike 48 is solid and hasan enlarged base 50 adjacent the drip meter 40.
  • the spike 48 has a point 52 at one end.
  • the opening 54 in base 50 communicates with air opening 56.
  • the opening 56 is normally provided with cotton 58 or other filtering material intended to entrap any airborne particulate matter or bacteria in the entering air.
  • the fluid passage 60 runs through the base 50 and functions as a downcomer for fluid. The lower end of passage 60 communicates with the tubular member 46.
  • FIGS. 1 and 2 are made up beginning as in FIG. 6 and concluding as in FIG. 7 whereby the spike 48 tips the center septum 16, allowing mixing and reconstitution to occur.
  • the flange 62 is brought up flush with the exterior of stopper 36 so that passage 60 is in fluid communication with the fluid contents of the vial 10.
  • the spike 48 is long enough to reach and tip septum 16 at or prior to the time the flange 62 is flush with stopper 36.
  • FIG. 8 shows another embodiment of this invention wherein the via] 64, annular ring 66, center septum 68 and end stopper 70 have the structure previously described.
  • the drip meter 72 has an outlet 74 provided with tubing 76 and a fluid inlet comprising the tubular member 78.
  • the rigid spike 80 is hollow and has a central opening 82 and a scarf or point 84 at one end.
  • the opening 82 communicates with the air opening 86.
  • the fluid passage 88 runs through the base 90 and communicates with tubular member 78.
  • the point 84 is above the initial fluid level in the vial 64 when the parts are fully assembled. Thus, the entering air is discharged at point 84, above the fluid level in the vial.
  • the septum 68 has a centrally domed surface 92 which facilitates the tipping of the septum by the spike 80.
  • the domed surface is particularly desirable where the spike is centrally disposed in the vial rather than offset from the centerline of the vial as shown in the drawings.
  • the tipping action afforded by the annular ring and septum allows the chamber adjacent the closed end of the vial to be smaller than the diameter of the septum. In other words, by providing for tipping action, this chamber can be substantially reduced in length since it does not receive the septum in length. This function reduces glass usage and saves space.
  • the end stopper has a circular area bridged by a thin imperforate diaphragm 94.
  • the diaphragm is readily punctured by the point of the spike.
  • a novel device for the administration of intravenous fluids which comprises a cylindrical fluid container having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said container, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid spike having an enlarged base adjacent said drip meter, said spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the spike at the exterior of said base so that essentially all of the fluid within said container can drain out by gravity through said fluid passage
  • a novel device for the administration of intravenous fluids which comprises a cylindrical fluid vial having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said vial, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby'drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid solid spike having an enlarged base adjacent said drip meter, said solid spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said solid spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the solid spike at the exterior of said base so that essentially all of the fluid within said container can drain out

Abstract

A device for the mixing and administration of intravenous fluid comprising a cylindrical vial having an open end and a closed end, an inwardly extending integral annular ring within the vial and forming part of the walls of the vial intermediate said open and closed ends. A tippable center septum seals on the annular ring. An imperforate stopper is provided in the open end of the vial. The vial is adapted to contain two liquids or a liquid and a dry material in separated state. A non-opaque drip meter having a fluid outlet at one end and a fluid inlet is provided, the inlet comprising a tubular member terminating within the drip meter whereby drops can be visually observed at the end of the tubular member through the drip meter. Extending from the drip meter is a solid or hollow elongated rigid spike having an enlarged base adjacent the drip meter, the spike terminating in a point at its other end. A filtered air inlet is positioned in proximity to the base of the spike, a passage and filter are associated with the spike or base for admitting filtered air into the vial. A fluid passage runs through the base and has one end adjacent the spike at the exterior of the base and the other end communicates with the tubular member. The spike is adapted to puncture the stopper and tip the septum whereby the contents of the vial can be mixed without contamination from the exterior and the fluid contents of the vial can flow through the fluid passage and the drip meter while filtered air passes into the vial.

Description

United States Patent 1 1 Ogle 1 Jan. 7, 1975 1 INTRAVENOUS CONTAINER MIXING ASSEMBLY Robert W. Ogle, Newport Beach, Calif.
[73] Assignee: lMS Limited, Wilmington, Del.
[22] Filed: Nov. 1, 1972 [21] Appl. No.: 302,783
Related US. Application Data [60] Continuation-in-part of Ser. No. 195,886, Nov. 4, 1971, which is a division of Ser. No. 830,311, June 4, 1969, Pat. No. 3,674,028.
[75] Inventor:
[52] US. Cl. 128/214 C, 128/221, 222/81 {51] Int. Cl A61m 5/16 [58] Field of Search 128/272, 221, 218 M, DIG. 28,
[56] References Cited UNITED STATES PATENTS 2,111,985 3/1938 Meyer 215/6X 2,232,978 2/1941 Smith l28/D1G. 28 2,377,274 5/1945 Smith 128/218 M 2,610,628 9/1952 Lockhart 128/D1G. 28 3,467,097 9/1969 Ogle l28/D1G. 28 3,494,359 2/1970 Zackheim 128/218 M 3,670,728 6/1972 Dabney 128/214 C FOREIGN PATENTS OR APPLICATIONS 1,071,557 3/1954 France 128/214 C 1,225,859 7/1960 France 128/214 C 66,274 3/1956 France 128/214 C Primary ExaminerRichard A. Gaudct Assistant lz'xuminerl. C. McGowan Attorney, Agent, or FirmWills, Green & Muetli [57] ABSTRACT A device for the mixing and administration of intrave nous fluid comprising a cylindrical vial having an open end and a closed end, an inwardly extending integral annular ring within the vial and forming part of the walls of the vial intermediate said open and closed ends. A tippable center septum seals on the annular ring. An imperforate stopper is provided in the open end of the vial. The vial is adapted to contain two liquids or a liquid and a dry material in separated state. A non-opaque drip meter having a fluid outlet at one end and a fluid inlet is provided, the inlet comprising a tubular member terminating within the drip meter whereby drops can be visually observed at the end of the tubular member through the drip meter. Extending from the drip meter is a solid or hollow elongated rigid spike having an enlarged base adjacent the drip meter, the spike terminating in a point at its other end. A filtered air inlet is positioned in proximity to the base of the spike, a passage and filter are associated with the spike or base for admitting filtered air into the vial. A fluid passage runs through the base and has one end adjacent the spike at the exterior of the base and the other end communicates with the tubular member. The spike is adapted to puncture the stopper and tip the septum whereby the contents of the vial can be mixed without contamination from the exterior and the fluid contents of the vial can flow through the fluid passage and the drip meter while filtered air passes into the vial.
9 Claims, 8 Drawing Figures Patented Jan. 7, 1975 2 Sheets-Sheet 1 FlG.-4
.G w M H m .H 4 UQ/ 1 INTRAVENOUS CONTAINER MIXING ASSEMBLY This application is a continuation-in-part of Application Se'r. No. 195,886, filed Nov. 4, 1971, which was a divisional application of Application Ser. No. 830,311, filed June 4, 1969 and now issued as US. Pat. No. 3,674,028.
BACKGROUND OF INVENTION Various intravenous solution sets are known in the prior art. In general, these devices involve the drip meter assembly which has a sharp puncturing member at its upper end for piercing the stopper of a bottle of intravenous solution. The puncturing member normally has associated therewith an air inlet and a fluid outlet. Many medicaments must be stored and packaged in a dry or lyophilized state, and require reconstitution with a liquid diluentjust prior to use. Heretofore, the reconstitution of such materials for administration in an intravenous set required the nurse or technician to make one or more transfers of diluent in an open and uncontrollable manner. This procedure carries with it the grave risk of bacterial contamination. It also creates the chance of a mistake occurring as the result of a mix-up of solution bottles. The present invention is basically concerned with eliminating these problems and hazards by providing a closed system in which the solid medicament and its diluent can be packaged under strict sterile conditions at the factory, and reconstituted at the time of use without the necessity of the medicament becoming contaminated during a transfer operation. It is the art of administering intravenous solutions.
SUMMARY OF INVENTION Briefly, this invention comprises a novel device for the mixing and administration of intravenous fluid comprising a cylindrical vial having an open end and a closed end, an inwardly extending integral annular ring within said vial and forming part of the walls of said vial intermediate said open and closed ends, a tippable center septum sealing on said annular ring, an imperforate stopper in said open end, said vial being adapted to contain two liquids or a liquid and a dry material in separated state, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter a solid or hollow elongated rigid spike having an enlarged base adjacent said drip meter, said spike terminating in a point at its other end, a filtered air inlet positioned in proximity to the base of said spike, means associated with said spike or base for admitting filtered air into said vial, a fluid passage running through said base and having one end adjacent the spike at the exterior of said base and the other end communicating with said tubular member, said spike being adapted to puncture said stopper and tip said septum whereby the contents of the vial can be mixed without contamination from the exterior and the fluid contents of said vial can flow through said fluid passage and said drip meter while filtered air passes into said vial.
It is an object of my invention to provide a novel device for the administration of intravenous fluids.
More particularly, it is an object of this invention to provide a novel device which is adapted for the administration and reconstitution of medicament in a completely closed system.
Another object of this invention is to provide a novel device for the packaging and administration of medicament for intravenous use which during storage is maintained in separated condition, viz, two liquids or a liquid and a dry material.
These and other objects and advantages of this invention will be apparent from the detailed description which follows.
DESCRIPTION OF PREFERRED EMBODIMENTS.
Turning to the drawings:
FIG. 1 shows one embodiment of the drip meter and spike of this invention.
FIG. 2 is a top viewof the device of FIG. 1.
FIG. 3 is a bottom view of the device of FIG. 1.
FIG. 4 shows, in side sectional view, one embodiment of the vial, center septum and end stopper of this invention.
FIG. 5 is a plan view of the end stopper of the vial of FIG. 4.
FIG. 6 shows, in sectional view, the parts of FIGS. 1-5 in partially assembled condition.
FIG. 7 is a sectional view of the parts of FIG. 1-5 in fully assembled condition.
FIG. 8 is a sectional view of another embodiment of this invention.
Considering the drawings in greater detail, the cylindrical vial 10 has an open end 12 and a closed end 14. The center septum 16 is positioned just above and abuts the integral annular ring 18. Below ring 18 is chamber 20 which contains a dry or lyophilized medicament 22. The septum 16 has four sealing rings 24, 26, 28 and 30 which form a seal on the inside walls of the vial 10. A chamber 32 for liquid or diluent 34 is provided between septum 16 and the end stopper 36. The end stopper 36, unlike septum I6, is non-reciprocating; that is, it is not slidable downwardly within vial 10, such movement being prevented by shoulders 38 which overlay and may seal upon the ends of vial10.
The drip meter 40 has an outlet 42 provided with tubing 44 normally intended to carry the intravenous solution to the patient in conventional fashion. The drip meter 40 is normally non-opaque; that is, transparent or translucent so that drops of fluid may be observed and/or counted. The drip meter 40 has a fluid inlet comprising a tubular member 46 which terminates within the non-opaque drip meter. In FIGS. 1-7, the rigid spike 48 is solid and hasan enlarged base 50 adjacent the drip meter 40. The spike 48 has a point 52 at one end. The opening 54 in base 50 communicates with air opening 56. The opening 56 is normally provided with cotton 58 or other filtering material intended to entrap any airborne particulate matter or bacteria in the entering air. The fluid passage 60 runs through the base 50 and functions as a downcomer for fluid. The lower end of passage 60 communicates with the tubular member 46.
In use, the parts shown in FIGS. 1 and 2 are made up beginning as in FIG. 6 and concluding as in FIG. 7 whereby the spike 48 tips the center septum 16, allowing mixing and reconstitution to occur. The flange 62 is brought up flush with the exterior of stopper 36 so that passage 60 is in fluid communication with the fluid contents of the vial 10. The spike 48 is long enough to reach and tip septum 16 at or prior to the time the flange 62 is flush with stopper 36.
FIG. 8 shows another embodiment of this invention wherein the via] 64, annular ring 66, center septum 68 and end stopper 70 have the structure previously described. The drip meter 72 has an outlet 74 provided with tubing 76 and a fluid inlet comprising the tubular member 78. In this embodiment, the rigid spike 80 is hollow and has a central opening 82 and a scarf or point 84 at one end. The opening 82 communicates with the air opening 86. The fluid passage 88 runs through the base 90 and communicates with tubular member 78. In this embodiment the point 84 is above the initial fluid level in the vial 64 when the parts are fully assembled. Thus, the entering air is discharged at point 84, above the fluid level in the vial. This effectively reduces the risk of contamination of the fluid by the incoming air. Also, in FIG. 8 the septum 68 has a centrally domed surface 92 which facilitates the tipping of the septum by the spike 80. The domed surface is particularly desirable where the spike is centrally disposed in the vial rather than offset from the centerline of the vial as shown in the drawings.
It is to be noted that the tipping action afforded by the annular ring and septum, allows the chamber adjacent the closed end of the vial to be smaller than the diameter of the septum. In other words, by providing for tipping action, this chamber can be substantially reduced in length since it does not receive the septum in length. This function reduces glass usage and saves space.
Preferably, the end stopper has a circular area bridged by a thin imperforate diaphragm 94. The diaphragm is readily punctured by the point of the spike.
Having fully described the invention, it is intended that it be limited only by the scope of the appended claims.
Iclaim: V
l. A novel device for the administration of intravenous fluids which comprises a cylindrical fluid container having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said container, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid spike having an enlarged base adjacent said drip meter, said spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the spike at the exterior of said base so that essentially all of the fluid within said container can drain out by gravity through said fluid passage, and the other end of said fluid passage communi eating with said tubular member, the point of said spike beingadapted to puncture said stopper and tip said septum whereby contents of said container can be mixed without contamination from the exterior and the fluid contents can flow through said fluid passage and drip meter while filtered air passes into said vial.
2. A novel device for the administration of intravenous fluids which comprises a cylindrical fluid vial having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said vial, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby'drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid solid spike having an enlarged base adjacent said drip meter, said solid spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said solid spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the solid spike at the exterior of said base so that essentially all of the fluid within said container can drain out by gravity through said fluid passage, and the other end of said fluid passage communicating with said tubular member, the point of said solid spike being adapted to puncture said stopper and tip said septum whereby contents of said vial can be mixed without contamination from the exterior and the fluid contents can flow through said fluid passage and drip meter while filtered air passes into said vial.
3. The device of claim 2 wherein said solid spike is offset from the centerline of said vial.
4. The device of claim 2 wherein said septum has a centrally domed surface facing said stopper.
5. The device of claim 2 wherein said drip meter has an external flange which abuts said end stopper.
6. The device of claim 2 wherein said end stopper is non-reciprocating.
7. The device of claim 2 wherein said chamber adjacent said closed end is shorter than the diameter of said septum.
with said filtered air inlet.

Claims (9)

1. A novel device for the administration of intravenous fluids which comprises a cylindrical fluid container having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said container, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid spike having an enlarged base adjacent said drip meter, said spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the spike at the exterior of said base so that essentially all of the fluid within said container can drain out by gravity through said fluid passage, and the other end of said fluid passage communicating with said tubular member, the point of said spike being adaptEd to puncture said stopper and tip said septum whereby contents of said container can be mixed without contamination from the exterior and the fluid contents can flow through said fluid passage and drip meter while filtered air passes into said vial.
2. A novel device for the administration of intravenous fluids which comprises a cylindrical fluid vial having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said vial, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid solid spike having an enlarged base adjacent said drip meter, said solid spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said solid spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the solid spike at the exterior of said base so that essentially all of the fluid within said container can drain out by gravity through said fluid passage, and the other end of said fluid passage communicating with said tubular member, the point of said solid spike being adapted to puncture said stopper and tip said septum whereby contents of said vial can be mixed without contamination from the exterior and the fluid contents can flow through said fluid passage and drip meter while filtered air passes into said vial.
3. The device of claim 2 wherein said solid spike is offset from the centerline of said vial.
4. The device of claim 2 wherein said septum has a centrally domed surface facing said stopper.
5. The device of claim 2 wherein said drip meter has an external flange which abuts said end stopper.
6. The device of claim 2 wherein said end stopper is non-reciprocating.
7. The device of claim 2 wherein said chamber adjacent said closed end is shorter than the diameter of said septum.
8. The device of claim 7 wherein said septum has a plurality of rings sealing on the walls of said vial.
9. The device of claim 1 wherein said spike is hollow and has a central internal passage which communicates with said filtered air inlet.
US05302783 1969-06-04 1972-11-01 Intravenous container mixing assembly Expired - Lifetime US3858580A (en)

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CA161,659A CA1001513A (en) 1972-11-01 1973-01-19 Intravenous container mixing assembly
US05/587,151 USRE29062E (en) 1972-11-01 1975-06-16 Intravenous container mixing assembly

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US83031169A 1969-06-04 1969-06-04
US19588671A 1971-11-04 1971-11-04
US05302783 US3858580A (en) 1969-06-04 1972-11-01 Intravenous container mixing assembly

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US4979941A (en) * 1989-12-05 1990-12-25 International Medication Systems, Limited Device suitable for mixing medication
US5226878A (en) * 1992-01-10 1993-07-13 Whitaker Designs, Inc. Two-container system for mixing medicament with diluent including safety wand to protect against improper titration
US5358501A (en) * 1989-11-13 1994-10-25 Becton Dickinson France S.A. Storage bottle containing a constituent of a medicinal solution
WO1998056438A1 (en) * 1997-06-10 1998-12-17 Astra Pharmaceuticals Pty. Ltd. Prefilled container
US6065828A (en) * 1997-02-26 2000-05-23 Hewlett-Packard Company Selectable mixing of inkjet ink components
US6481435B2 (en) * 1998-10-17 2002-11-19 Boehringer Ingelheim Pharma Kg Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage
US20030153865A1 (en) * 2002-02-11 2003-08-14 Brian Connell Dialysis connector and cap having an integral disinfectant
US20030181849A1 (en) * 2002-02-11 2003-09-25 Castellanos Rafael A. Enclosure with cam action snap release
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US20050241634A1 (en) * 1996-04-19 2005-11-03 Dieter Hochrainer Two-chamber cartridge for propellant-free metering aerosols
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US20100130919A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from the patient's peritoneal cavity
US20100130918A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from supply containers and associated fill tubing
FR2941371A1 (en) * 2009-01-28 2010-07-30 Alaxia DEVICE FOR THE EXTENDED PREPARATION OF MEDICINAL PREPARATIONS
US20100198138A1 (en) * 2009-01-30 2010-08-05 Baxter International Inc. Transfer sets for therapy optimization
US8882700B2 (en) 2008-05-02 2014-11-11 Baxter International Inc. Smart patient transfer set for peritoneal dialysis
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US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
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US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
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Cited By (61)

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WO1988002161A1 (en) * 1985-07-18 1988-03-24 Carol Smith Method and apparatus for injection of pharmaceuticals
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US5358501A (en) * 1989-11-13 1994-10-25 Becton Dickinson France S.A. Storage bottle containing a constituent of a medicinal solution
US4979941A (en) * 1989-12-05 1990-12-25 International Medication Systems, Limited Device suitable for mixing medication
US5226878A (en) * 1992-01-10 1993-07-13 Whitaker Designs, Inc. Two-container system for mixing medicament with diluent including safety wand to protect against improper titration
US20050241634A1 (en) * 1996-04-19 2005-11-03 Dieter Hochrainer Two-chamber cartridge for propellant-free metering aerosols
US7980243B2 (en) 1996-04-19 2011-07-19 Boehringer Ingelheim Pharma Gmbh & Co., Kg Two-chamber cartridge for propellant-free metering aerosols
US7793655B2 (en) 1996-04-19 2010-09-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-chamber cartridge for propellant-free metering aerosols
US20080033391A1 (en) * 1996-04-19 2008-02-07 Boehringer Ingelheim Kg Two-Chamber Cartridge For Propellant-Free Metering Aerosols
US7213593B2 (en) 1996-04-19 2007-05-08 Boehringer Ingelheim Kg Two-chamber cartridge for propellant-free metering aerosols
US6065828A (en) * 1997-02-26 2000-05-23 Hewlett-Packard Company Selectable mixing of inkjet ink components
WO1998056438A1 (en) * 1997-06-10 1998-12-17 Astra Pharmaceuticals Pty. Ltd. Prefilled container
US7040311B2 (en) 1998-10-17 2006-05-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage
US20060196500A1 (en) * 1998-10-17 2006-09-07 Boehringer Ingelheim Pharma Kmbh & Co. Kg Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage
US6986346B2 (en) * 1998-10-17 2006-01-17 Boehringer Ingelheim Pharma Kg Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage
US6481435B2 (en) * 1998-10-17 2002-11-19 Boehringer Ingelheim Pharma Kg Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage
US20030066524A1 (en) * 1998-10-17 2003-04-10 Boehringer Ingelheim Pharma Kg Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage
US7232419B2 (en) 2002-02-11 2007-06-19 Baxter International Inc. Enclosure with cam action snap release
US7198611B2 (en) 2002-02-11 2007-04-03 Baxter International Inc. Dialysis connector and cap having an integral disinfectant
US20030181849A1 (en) * 2002-02-11 2003-09-25 Castellanos Rafael A. Enclosure with cam action snap release
US20070106205A1 (en) * 2002-02-11 2007-05-10 Baxter International Inc. Dialysis connector and cap having an integral disinfectant
US20030153865A1 (en) * 2002-02-11 2003-08-14 Brian Connell Dialysis connector and cap having an integral disinfectant
WO2004052430A2 (en) * 2002-12-09 2004-06-24 Zi Medical Plc Infusion apparatus for infusion bags
WO2004052430A3 (en) * 2002-12-09 2004-08-12 Zi Medical Plc Infusion apparatus for infusion bags
US20060058741A1 (en) * 2002-12-09 2006-03-16 George Gallagher Infusion apparatus for infusion bags
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US20090275881A1 (en) * 2008-05-02 2009-11-05 Baxter International Inc. Optimizing therapy outcomes for peritoneal dialysis
US9348975B2 (en) 2008-05-02 2016-05-24 Baxter International Inc. Optimizing therapy outcomes for peritoneal dialysis
US8882700B2 (en) 2008-05-02 2014-11-11 Baxter International Inc. Smart patient transfer set for peritoneal dialysis
US20100130918A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from supply containers and associated fill tubing
US9555180B2 (en) 2008-11-21 2017-01-31 Baxter International Inc. Systems and methods for removing air from the patient's peritoneal cavity
US20100130919A1 (en) * 2008-11-21 2010-05-27 Baxter International Inc. Systems and methods for removing air from the patient's peritoneal cavity
US20100221818A1 (en) * 2009-01-28 2010-09-02 Alaxia Device for the extemporaneous preparation of active preparations
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CA1001513A (en) 1976-12-14

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