US3874380A - Dual nozzle intranasal delivery device - Google Patents

Dual nozzle intranasal delivery device Download PDF

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Publication number
US3874380A
US3874380A US473372A US47337274A US3874380A US 3874380 A US3874380 A US 3874380A US 473372 A US473372 A US 473372A US 47337274 A US47337274 A US 47337274A US 3874380 A US3874380 A US 3874380A
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Prior art keywords
opening
cavity
container
reception
nozzle
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Expired - Lifetime
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US473372A
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Ronald Baum
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SmithKline Beecham Corp
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SmithKline Corp
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Assigned to SMITHKLINE BECKMAN CORPORATION reassignment SMITHKLINE BECKMAN CORPORATION CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). EFFECTIVE DATE: 03/04/82 Assignors: SMITHKLINE CORPORATION
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • a dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening.
  • a hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container.
  • a pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
  • DUAL NOZZLE INTRANASAL DELIVERY DEVICE BACKGROUND OF THE INVENTION It is known to employ a pair of adjacent spray nozzles communicating with a conduit which is adapted to be connected to a syringe to deliver vaccine such as a flu vaccine or a measles vaccine in about equal doses to each nostril. While this operation is simple and effective, it still leaves the patient with a difficult problem in getting the dosage in liquid form in the syringe. This is particularly the case where the biological to be employed is lyophilized.
  • a lyophilized medicament can be placed in solution in a syringe under sterile conditions with great ease by an unskilled patient.
  • a dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception ofa syringe nozzle, and a passage connecting said cavity and said opening.
  • a hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container.
  • a pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
  • FIG. 1 is an exploded view of an intranasal delivery device in accordance with the invention together with a container and a syringe;
  • FIG. 2 is a section through the intranasal device of FIG. 1;
  • FIG. 3 is a view of the intranasal device of FIG. 1 taken on the plane indicated by the line 3-3 in FIG. 2;
  • FIG. 4 is an elevational view of the intranasal device of FIG. 1 shown together with a syringe.
  • An intranasal device 2 has a housing 4 provided with a cylindrical cavity 6 adapted to receive a container 8 typically containing a tablet 10 of a lyophilized biological.
  • Container 10 is of a type well known to the art and has a pierceable rubber stopper 14 which is held in position by a metal cap 16. Any of the wide variety of containers currently employed with syringes provided with a needle for piercing a container stopper may be employed.
  • Housing 4 has a passage 18 in which a hollow needle 20 is secured by a pressed fit. Needle 20 extends into 40 is in communication with a. conduit 44 which has a pair of branches 46 and 48.
  • a pair of spray nozzles 52 and 54 are substantially parallel and spaced apart a distance to permit one spray nozzle to enter each nostril.
  • Each of the spray nozzles has a cap 56 having a discharge passage 58, the passages 58, 58 being substantially parallel.
  • Each cap 56 has an interior opening 60 which is adapted to receive branches 46 and 48 respectively and a bead 62 adapted to snap into grooves 64 and 66 respectively in branches 46 and 48.
  • Branch 46 has a side opening 70 which discharges into cavity 72 in the cap 56 mounted on branch 46.
  • branch 48 has a side discharge opening 74 which discharges into cavity 76 of the cap 56 mounted on branch 48.
  • the spray nozzles per se are conventional and any spray nozzles conventionally used for spraying liquids into the nose may be employed.
  • container 8 is inserted into cavity 6 and thrust home causing needle 20 to pierce the pierceable rubber stopper l4 and extend into the interior of container 8.
  • nozzle 28 pointing upwardly, cover 32 is removed from nozzle 28 of syringe 30 which contains a suitable reconstituting liquid and the nozzle 28 is inserted into opening 26.
  • Plunger 34 is then advanced to force the reconstituting liquid from syringe 30 into container 8.
  • plunger 34 is retracted to draw the thus formed solution into the syringe 30.
  • the syringe 30 is now withdrawn from opening 26 and its nozzle is inserted into opening 40. With the spray nozzles 52 and 54 inserted into the patients nostrils, plunger 34 is depressed so as to force the contained liquid into conduit 44 and equally through branches 46 and 48 and through spray nozzles 52 and 54.
  • a dual nozzle intranasal delivery device comprising:
  • said housing having a cavity for the reception of a container having a pierceable stopper
  • said housing having a conduit communicating with said nozzles and having a second opening for the reception of a syringe nozzle, and a second passage connecting said second opening with said nozzles, whereby liquid can be introduced into and withdrawn from a container and then discharged through the nozzles.

Abstract

A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.

Description

United States Patent Inventor: Ronald Baum, Merion, Pa.
Smithkline Corporation, Philadelphia, Pa.
Filed: May 28, 1974 Appl. No.: 473,372
Assignee:
References Cited UNITED STATES PATENTS 9/1902 Gundlach et a1. 128/235 Baum Apr. 1, 1975 [54] DUAL NOZZLE INTRANASAL DELIVERY 1,930,929 10/1933 Eisenberg .Q. 128/235 DEVICE 3,330,277 7/1967 Gabriels 128/218 R Primary E.\'aminer Richard A. Gaudet Assistant Examiner-Henry J, Recla Attorney, Agent, or Firm -Smith, Harding, Earley & Follmer [5 7] AB STRA CT A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
1 Claim, 4 Drawing Figures Z ATENTED APR 1 FIG.4.
DUAL NOZZLE INTRANASAL DELIVERY DEVICE BACKGROUND OF THE INVENTION It is known to employ a pair of adjacent spray nozzles communicating with a conduit which is adapted to be connected to a syringe to deliver vaccine such as a flu vaccine or a measles vaccine in about equal doses to each nostril. While this operation is simple and effective, it still leaves the patient with a difficult problem in getting the dosage in liquid form in the syringe. This is particularly the case where the biological to be employed is lyophilized. In accordance with this invention a lyophilized medicament can be placed in solution in a syringe under sterile conditions with great ease by an unskilled patient.
BRIEF SUMMARY OF THE INVENTION A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception ofa syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an exploded view of an intranasal delivery device in accordance with the invention together with a container and a syringe;
FIG. 2 is a section through the intranasal device of FIG. 1;
FIG. 3 is a view of the intranasal device of FIG. 1 taken on the plane indicated by the line 3-3 in FIG. 2; and
FIG. 4 is an elevational view of the intranasal device of FIG. 1 shown together with a syringe.
DETAILED DESCRIPTION An intranasal device 2 has a housing 4 provided with a cylindrical cavity 6 adapted to receive a container 8 typically containing a tablet 10 of a lyophilized biological. Container 10 is of a type well known to the art and has a pierceable rubber stopper 14 which is held in position by a metal cap 16. Any of the wide variety of containers currently employed with syringes provided with a needle for piercing a container stopper may be employed.
Housing 4 has a passage 18 in which a hollow needle 20 is secured by a pressed fit. Needle 20 extends into 40 is in communication with a. conduit 44 which has a pair of branches 46 and 48. A pair of spray nozzles 52 and 54 are substantially parallel and spaced apart a distance to permit one spray nozzle to enter each nostril. Each of the spray nozzles has a cap 56 having a discharge passage 58, the passages 58, 58 being substantially parallel. Each cap 56 has an interior opening 60 which is adapted to receive branches 46 and 48 respectively and a bead 62 adapted to snap into grooves 64 and 66 respectively in branches 46 and 48. Branch 46 has a side opening 70 which discharges into cavity 72 in the cap 56 mounted on branch 46. Similarly branch 48 has a side discharge opening 74 which discharges into cavity 76 of the cap 56 mounted on branch 48. The spray nozzles per se are conventional and any spray nozzles conventionally used for spraying liquids into the nose may be employed.
OPERATION Assuming that a lyophilized biological such as the tablet 10 is to be administered, container 8 is inserted into cavity 6 and thrust home causing needle 20 to pierce the pierceable rubber stopper l4 and extend into the interior of container 8.. With nozzle 28 pointing upwardly, cover 32 is removed from nozzle 28 of syringe 30 which contains a suitable reconstituting liquid and the nozzle 28 is inserted into opening 26. Plunger 34 is then advanced to force the reconstituting liquid from syringe 30 into container 8. When the biological tablet 10 has dissolved in the reconstituting liquid, plunger 34 is retracted to draw the thus formed solution into the syringe 30. The syringe 30 is now withdrawn from opening 26 and its nozzle is inserted into opening 40. With the spray nozzles 52 and 54 inserted into the patients nostrils, plunger 34 is depressed so as to force the contained liquid into conduit 44 and equally through branches 46 and 48 and through spray nozzles 52 and 54.
It will be understood that the foregoing description is illustrative and not limiting.
I claim:
1. A dual nozzle intranasal delivery device compris ing:
a housing,
said housing having a cavity for the reception of a container having a pierceable stopper,
an opening for the reception of a syringe nozzle and a passage connecting said cavity and said opening, a hollow needle secured in said passage by a pressed fit and extending into the cavity, said needle being adapted to penetrate the stopper of said container,
a pair of adjacent nozzles having substantially parallel axes,
said housing having a conduit communicating with said nozzles and having a second opening for the reception of a syringe nozzle, and a second passage connecting said second opening with said nozzles, whereby liquid can be introduced into and withdrawn from a container and then discharged through the nozzles.

Claims (1)

1. A dual nozzle intranasal delivery device comprising: a housing, said housing having a cavity for the reception of a container having a pierceable stopper, an opening for the reception of a syringe nozzle and a passage connecting said cavity and said opening, a hollow needle secured in said passage by a pressed fit and extending into the cavity, said needle being adapted to penetrate the stopper of said container, a pair of adjacent nozzles having substantially parallel axes, said housing having a conduit communicating with said nozzles and having a second opening for the reception of a syringe nozzle, and a second passage connecting said second opening with said nozzles, whereby liquid can be introduced into and withdrawn from a container and then discharged through the nozzles.
US473372A 1974-05-28 1974-05-28 Dual nozzle intranasal delivery device Expired - Lifetime US3874380A (en)

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Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933155A (en) * 1975-01-23 1976-01-20 Mizzy Inc. Pressure injector apparatus having improved trigger mechanism
US4475915A (en) * 1982-05-07 1984-10-09 Sloane Glenn L Holder for a syringe and an ampoule
US5026357A (en) * 1986-09-22 1991-06-25 Schering Ag Injection device
US5240047A (en) * 1992-05-06 1993-08-31 Hedges Harry S Syringe guide and bottle holder
US5433191A (en) * 1992-05-15 1995-07-18 Habley Medical Technology Corp. Medication sprayer
US5505236A (en) * 1994-04-04 1996-04-09 Abbott Laboratories Anesthetic vaporizer filling system
US5601077A (en) * 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
WO1997039831A1 (en) * 1996-04-19 1997-10-30 Boehringer Ingelheim Pharma Kg Two-chamber cartridge for propellant-free metered aerosols
US5894870A (en) * 1997-06-10 1999-04-20 Pharmacia & Upjohn Company Syringe guide and vial holder
US5899202A (en) * 1995-06-30 1999-05-04 Unisia Jecs Corporation Medicine administering device for nasal cavities and method of using same
FR2771012A1 (en) * 1997-11-17 1999-05-21 Sofab Nasal spray which allows both nostrils to be treated at the same time
US5961489A (en) * 1997-10-08 1999-10-05 Shinko Kagaku Kabushiki Kaisha Spray adaptors for spraying collunarium and sprayers employing the spray adaptors
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
US6431172B1 (en) * 2000-10-20 2002-08-13 Mallinckrodt Inc. Nasal cannula with inflatable plenum chamber
WO2002074375A1 (en) * 2001-03-20 2002-09-26 Aradigm Corporation Aerosol generation using sterile multiple dose containers
US20030047184A1 (en) * 2001-01-12 2003-03-13 Lockhart Artis R. Medicament respiratory delivery device
US6585016B1 (en) 2002-03-15 2003-07-01 Datex-Ohmeda, Inc. Keyed anesthetic vaporizer filling system
US6718969B1 (en) * 2002-05-28 2004-04-13 Darren Rubin Medication dosage inhaler system
US20040134562A1 (en) * 2003-01-14 2004-07-15 Engel Steven P. Connector device for sealing and dispensing freeze-dried preparations
WO2005046773A1 (en) * 2003-11-10 2005-05-26 Mb Innovation Disposable medicated-fluid-spray device
US7296566B2 (en) 1999-10-14 2007-11-20 Becton, Dickinson And Company Nasal delivery device including spray nozzle
US20110083665A1 (en) * 2003-12-16 2011-04-14 Wolfe Tory Medical, Inc. Vial multi-access adapter
US20130269684A1 (en) * 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US20140124087A1 (en) * 2012-11-08 2014-05-08 Nordson Corporation Fluid delivery assemblies for withdrawing biomaterial fluid from a vial and for dispensing the biomaterial fluid, fluid control devices therefor, and related methods
CN103785090A (en) * 2003-12-31 2014-05-14 雷斯梅德有限公司 Compact oronasal patient interface
WO2015104511A1 (en) 2014-01-13 2015-07-16 Aptar France Sas Method for using an assembly for dispensing a fluid product
US20160279332A1 (en) * 2013-11-01 2016-09-29 Consort Medical Plc Medicament delivery device sub-assembly
US20170340869A1 (en) * 2013-03-26 2017-11-30 George Naoum Device and Method of Controlled Provision of Therapeutic Liquid in the Nose
US9883932B2 (en) 2009-10-19 2018-02-06 Aircom Manufacturing, Inc. Transdermal dispensing apparatus and methods
US20180064898A1 (en) * 2015-03-31 2018-03-08 Fisher & Paykel Healthcare Limited Nasal cannula
US10912914B2 (en) 2019-06-06 2021-02-09 GE Precision Healthcare LLC Systems and methods for bottle retention
US11400241B2 (en) 2010-01-12 2022-08-02 Aerami Therapeutics, Inc. Preservative-free single dose inhaler systems
EP4052746A4 (en) * 2019-11-06 2023-11-22 Nipro Corporation Syringe-type ejection device

Citations (3)

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US708224A (en) * 1901-10-18 1902-09-02 Frank C Gundlach Syringe.
US1930929A (en) * 1931-05-12 1933-10-17 Eisenberg Moses Joel Hypodermic implement
US3330277A (en) * 1964-08-17 1967-07-11 Scherer Corp R P Multidose hypodermic injector

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US708224A (en) * 1901-10-18 1902-09-02 Frank C Gundlach Syringe.
US1930929A (en) * 1931-05-12 1933-10-17 Eisenberg Moses Joel Hypodermic implement
US3330277A (en) * 1964-08-17 1967-07-11 Scherer Corp R P Multidose hypodermic injector

Cited By (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933155A (en) * 1975-01-23 1976-01-20 Mizzy Inc. Pressure injector apparatus having improved trigger mechanism
US4475915A (en) * 1982-05-07 1984-10-09 Sloane Glenn L Holder for a syringe and an ampoule
US5026357A (en) * 1986-09-22 1991-06-25 Schering Ag Injection device
US5601077A (en) * 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
US5240047A (en) * 1992-05-06 1993-08-31 Hedges Harry S Syringe guide and bottle holder
US5433191A (en) * 1992-05-15 1995-07-18 Habley Medical Technology Corp. Medication sprayer
US5505236A (en) * 1994-04-04 1996-04-09 Abbott Laboratories Anesthetic vaporizer filling system
US5899202A (en) * 1995-06-30 1999-05-04 Unisia Jecs Corporation Medicine administering device for nasal cavities and method of using same
WO1997039831A1 (en) * 1996-04-19 1997-10-30 Boehringer Ingelheim Pharma Kg Two-chamber cartridge for propellant-free metered aerosols
US20050241634A1 (en) * 1996-04-19 2005-11-03 Dieter Hochrainer Two-chamber cartridge for propellant-free metering aerosols
US7213593B2 (en) 1996-04-19 2007-05-08 Boehringer Ingelheim Kg Two-chamber cartridge for propellant-free metering aerosols
US7793655B2 (en) 1996-04-19 2010-09-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-chamber cartridge for propellant-free metering aerosols
CN1090538C (en) * 1996-04-19 2002-09-11 贝林格尔英格海姆法玛公司 Two-chamber cartridge for propellant-free metered aerosols
AU718754B2 (en) * 1996-04-19 2000-04-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-chamber cartridge for propellant-free metered aerosols
US7980243B2 (en) 1996-04-19 2011-07-19 Boehringer Ingelheim Pharma Gmbh & Co., Kg Two-chamber cartridge for propellant-free metering aerosols
US5894870A (en) * 1997-06-10 1999-04-20 Pharmacia & Upjohn Company Syringe guide and vial holder
US5961489A (en) * 1997-10-08 1999-10-05 Shinko Kagaku Kabushiki Kaisha Spray adaptors for spraying collunarium and sprayers employing the spray adaptors
WO1999025408A1 (en) * 1997-11-17 1999-05-27 Rexam Sofab Nose sprayer
FR2771012A1 (en) * 1997-11-17 1999-05-21 Sofab Nasal spray which allows both nostrils to be treated at the same time
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
US7296566B2 (en) 1999-10-14 2007-11-20 Becton, Dickinson And Company Nasal delivery device including spray nozzle
US6530371B2 (en) 1999-10-14 2003-03-11 Becton, Dickinson And Company Drug delivery system including holder and drug container
US6431172B1 (en) * 2000-10-20 2002-08-13 Mallinckrodt Inc. Nasal cannula with inflatable plenum chamber
US20030047184A1 (en) * 2001-01-12 2003-03-13 Lockhart Artis R. Medicament respiratory delivery device
US7270127B2 (en) * 2001-01-12 2007-09-18 Becton, Dickinson And Company Medicament respiratory delivery device
WO2002074375A1 (en) * 2001-03-20 2002-09-26 Aradigm Corporation Aerosol generation using sterile multiple dose containers
US6929041B2 (en) 2002-03-15 2005-08-16 Datex-Ohmeda, Inc. Keyed anesthetic vaporizer filling system
US6585016B1 (en) 2002-03-15 2003-07-01 Datex-Ohmeda, Inc. Keyed anesthetic vaporizer filling system
US6817390B2 (en) 2002-03-15 2004-11-16 Datex-Ohmeda, Inc. Keyed anesthetic vaporizer filling system
US20040206417A1 (en) * 2002-03-15 2004-10-21 Falligant John C. Keyed anesthetic vaporizer filling system
US20040089375A1 (en) * 2002-03-15 2004-05-13 Datex-Ohmeda, Inc. Keyed anesthetic vaporizer filling system
US6718969B1 (en) * 2002-05-28 2004-04-13 Darren Rubin Medication dosage inhaler system
US6779566B2 (en) * 2003-01-14 2004-08-24 Access Business Group International Llc Connector device for sealing and dispensing freeze-dried preparations
US20040134562A1 (en) * 2003-01-14 2004-07-15 Engel Steven P. Connector device for sealing and dispensing freeze-dried preparations
WO2005046773A1 (en) * 2003-11-10 2005-05-26 Mb Innovation Disposable medicated-fluid-spray device
US20110083665A1 (en) * 2003-12-16 2011-04-14 Wolfe Tory Medical, Inc. Vial multi-access adapter
US10806886B2 (en) 2003-12-31 2020-10-20 ResMed Pty Ltd Compact oronasal patient interface
CN103785090A (en) * 2003-12-31 2014-05-14 雷斯梅德有限公司 Compact oronasal patient interface
US11229762B2 (en) 2003-12-31 2022-01-25 ResMed Pty Ltd Compact oronasal patient interface
US10646677B2 (en) 2003-12-31 2020-05-12 ResMed Pty Ltd Compact oronasal patient interface
US11633562B2 (en) 2003-12-31 2023-04-25 ResMed Pty Ltd Compact oronasal patient interface
US10569042B2 (en) 2003-12-31 2020-02-25 ResMed Pty Ltd Compact oronasal patient interface
US11077275B2 (en) 2003-12-31 2021-08-03 ResMed Pty Ltd Compact oronasal patient interface
US9883932B2 (en) 2009-10-19 2018-02-06 Aircom Manufacturing, Inc. Transdermal dispensing apparatus and methods
US11400241B2 (en) 2010-01-12 2022-08-02 Aerami Therapeutics, Inc. Preservative-free single dose inhaler systems
US11786676B2 (en) 2010-01-12 2023-10-17 Aerami Therapeutics, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US11833291B2 (en) 2010-01-12 2023-12-05 Aerami Therapeutics, Inc. Preservative-free single dose inhaler systems
US20130269684A1 (en) * 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US20140124087A1 (en) * 2012-11-08 2014-05-08 Nordson Corporation Fluid delivery assemblies for withdrawing biomaterial fluid from a vial and for dispensing the biomaterial fluid, fluid control devices therefor, and related methods
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