US6534308B1 - Method and apparatus for selectively targeting specific cells within a mixed cell population - Google Patents
Method and apparatus for selectively targeting specific cells within a mixed cell population Download PDFInfo
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- US6534308B1 US6534308B1 US09/451,659 US45165999A US6534308B1 US 6534308 B1 US6534308 B1 US 6534308B1 US 45165999 A US45165999 A US 45165999A US 6534308 B1 US6534308 B1 US 6534308B1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0093—Purging against cancer cells
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/0088—Inverse microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
Abstract
Description
Claims (94)
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
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US09/451,659 US6534308B1 (en) | 1997-03-27 | 1999-11-30 | Method and apparatus for selectively targeting specific cells within a mixed cell population |
AT00982344T ATE520773T1 (en) | 1999-11-30 | 2000-11-30 | METHOD AND DEVICE FOR SELECTIVE TARGETING OF SPECIFIC CELLS WITHIN A CELL POPULATION |
EP10175331.7A EP2281879B1 (en) | 1999-11-30 | 2000-11-30 | Apparatus for determining a morphological or physiological characteristic of individual cells in a biological specimen |
PCT/US2000/032742 WO2001040454A1 (en) | 1999-11-30 | 2000-11-30 | Method and apparatus for selectively targeting specific cells within a cell population |
AU19392/01A AU785290B2 (en) | 1999-11-30 | 2000-11-30 | Method and apparatus for selectively targeting specific cells within a cell population |
JP2001542522A JP5087192B2 (en) | 1999-11-30 | 2000-11-30 | Method and apparatus for selectively aiming a specific cell in a cell group |
CA002392534A CA2392534A1 (en) | 1999-11-30 | 2000-11-30 | Method and apparatus for selectively targeting specific cells within a cell population |
EP00982344A EP1234026B1 (en) | 1999-11-30 | 2000-11-30 | Method and apparatus for selectively targeting specific cells within a cell population |
US09/728,281 US6514722B2 (en) | 1997-03-27 | 2000-11-30 | Method and apparatus for selectively targeting specific cells within a cell population |
US09/961,691 US6753161B2 (en) | 1997-03-27 | 2001-09-21 | Optoinjection methods |
US10/359,483 US7505618B2 (en) | 1997-03-27 | 2003-02-04 | Method and apparatus for selectively targeting specific cells within a cell population |
US10/392,636 US20030180902A1 (en) | 1997-03-27 | 2003-03-18 | Method and apparatus for selectively targeting specific cells within a mixed cell population |
US10/814,966 US7300795B2 (en) | 1997-03-27 | 2004-03-30 | Optoinjection methods |
US11/842,112 US20080014605A1 (en) | 1997-03-27 | 2007-08-20 | Method and Apparatus for Selectively Targeting Specific Cells Within a cell population |
US11/894,720 US20080050794A1 (en) | 1997-03-27 | 2007-08-20 | Optoinjection methods |
US12/405,875 US20090175529A1 (en) | 1997-03-27 | 2009-03-17 | Method and apparatus for selectively targeting specific cells within a cell population |
US12/533,801 US20100086984A1 (en) | 1997-03-27 | 2009-07-31 | Optoinjection methods |
US12/972,305 US20110201075A1 (en) | 1997-03-27 | 2010-12-17 | Optoinjection methods |
US12/986,792 US8401263B2 (en) | 1997-03-27 | 2011-01-07 | Method and apparatus for selectively targeting specific cells within a cell population |
JP2012004470A JP2012130341A (en) | 1999-11-30 | 2012-01-12 | Method and apparatus for selectively targeting specific cell within cell population |
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US08/824,968 US5874266A (en) | 1997-03-27 | 1997-03-27 | Targeted system for removing tumor cells from cell populations |
US09/049,677 US6143535A (en) | 1997-03-27 | 1998-03-27 | Targeted system for removing tumor cells from cell populations |
US09/451,659 US6534308B1 (en) | 1997-03-27 | 1999-11-30 | Method and apparatus for selectively targeting specific cells within a mixed cell population |
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US09/049,677 Continuation-In-Part US6143535A (en) | 1997-03-27 | 1998-03-27 | Targeted system for removing tumor cells from cell populations |
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US10/392,636 Division US20030180902A1 (en) | 1997-03-27 | 2003-03-18 | Method and apparatus for selectively targeting specific cells within a mixed cell population |
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US10/392,636 Abandoned US20030180902A1 (en) | 1997-03-27 | 2003-03-18 | Method and apparatus for selectively targeting specific cells within a mixed cell population |
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US10/392,636 Abandoned US20030180902A1 (en) | 1997-03-27 | 2003-03-18 | Method and apparatus for selectively targeting specific cells within a mixed cell population |
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