US6995013B2 - Cell-scaffold composition containing five layers - Google Patents
Cell-scaffold composition containing five layers Download PDFInfo
- Publication number
- US6995013B2 US6995013B2 US10/190,874 US19087402A US6995013B2 US 6995013 B2 US6995013 B2 US 6995013B2 US 19087402 A US19087402 A US 19087402A US 6995013 B2 US6995013 B2 US 6995013B2
- Authority
- US
- United States
- Prior art keywords
- cells
- cell
- layer
- recited
- scaffold composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active - Reinstated, expires
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
- A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Abstract
Description
Claims (20)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/190,874 US6995013B2 (en) | 2002-07-08 | 2002-07-08 | Cell-scaffold composition containing five layers |
US11/224,496 US20060094112A1 (en) | 2001-03-07 | 2005-09-12 | Biological scaffold |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/190,874 US6995013B2 (en) | 2002-07-08 | 2002-07-08 | Cell-scaffold composition containing five layers |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/224,496 Continuation-In-Part US20060094112A1 (en) | 2001-03-07 | 2005-09-12 | Biological scaffold |
Publications (2)
Publication Number | Publication Date |
---|---|
US20040005297A1 US20040005297A1 (en) | 2004-01-08 |
US6995013B2 true US6995013B2 (en) | 2006-02-07 |
Family
ID=29999916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/190,874 Active - Reinstated 2024-05-07 US6995013B2 (en) | 2001-03-07 | 2002-07-08 | Cell-scaffold composition containing five layers |
Country Status (1)
Country | Link |
---|---|
US (1) | US6995013B2 (en) |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030232071A1 (en) * | 2002-04-18 | 2003-12-18 | Gower Laurie B. | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
US20040131562A1 (en) * | 2002-04-18 | 2004-07-08 | Gower Laurie B. | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
US20040230303A1 (en) * | 2003-05-16 | 2004-11-18 | Gomes Katherine A. | Cartilage allograft plug |
US20050049640A1 (en) * | 2003-05-12 | 2005-03-03 | Gurtner Geoffrey C. | Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2 |
US20050152990A1 (en) * | 2002-04-18 | 2005-07-14 | Gower Laurie B. | Fibrous minerals, methods for their production using a solution-precursor-solid mechanism, and methods of use |
US20060057693A1 (en) * | 2003-08-20 | 2006-03-16 | Ebi, L.P. | Methods of treatment using electromagnetic field stimulated stem cells |
US20060094112A1 (en) * | 2001-03-07 | 2006-05-04 | Omotunde Babalola | Biological scaffold |
US20070009610A1 (en) * | 2005-07-11 | 2007-01-11 | Carina Syring | Engineered osteochondral construct for treatment of articular cartilage defects |
US20070105769A1 (en) * | 2005-11-07 | 2007-05-10 | Ebi, L.P. | Methods of treating tissue defects |
US20080133008A1 (en) * | 2003-04-29 | 2008-06-05 | Muscuoskeletal Transplant Foundation | Cartilage repair mixture containing allograft chondrocytes |
US20080217263A1 (en) * | 2007-03-06 | 2008-09-11 | Biomet Biologics, Inc. | Angiogenesis initation and growth |
US20080248572A1 (en) * | 2007-04-06 | 2008-10-09 | Gambro Bct, Inc. | Bioreactor Surfaces |
WO2008150814A2 (en) | 2007-05-29 | 2008-12-11 | Reid Christopher B | Methods for production and uses of multipotent cell populations |
WO2008153968A2 (en) | 2007-06-07 | 2008-12-18 | Wake Forest University Health Sciences | Inkjet gene printing |
US20090248047A1 (en) * | 2008-03-28 | 2009-10-01 | Marrs Brock H | Carbon fiber reinforced carbon foams for repair and reconstruction of bone defects |
US20090319045A1 (en) * | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US20100015202A1 (en) * | 2007-03-06 | 2010-01-21 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US20100274362A1 (en) * | 2009-01-15 | 2010-10-28 | Avner Yayon | Cartilage particle tissue mixtures optionally combined with a cancellous construct |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20110172611A1 (en) * | 2010-01-08 | 2011-07-14 | Yoo James J | Delivery system |
US20120028275A1 (en) * | 2010-07-27 | 2012-02-02 | Gambro Lundia Ab | Biomimetic membrane for cell expansion |
US20120177702A1 (en) * | 2009-06-15 | 2012-07-12 | Cartiheal (2009) Ltd. | Solid Forms for Tissue Repair |
WO2012122105A1 (en) | 2011-03-07 | 2012-09-13 | Wake Forest University Health Sciences | Delivery system |
US8632489B1 (en) | 2011-12-22 | 2014-01-21 | A. Mateen Ahmed | Implantable medical assembly and methods |
US8808725B2 (en) | 2008-11-20 | 2014-08-19 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US20140371869A1 (en) * | 2005-03-11 | 2014-12-18 | Wake Forest University Health Sciences | Production of tissue engineered digits and limbs |
US20150134065A1 (en) * | 2009-06-15 | 2015-05-14 | Cartiheal (2009) Ltd | Mulit-Phasic Solid Implants for Tissue Repair |
US9381112B1 (en) | 2011-10-06 | 2016-07-05 | William Eric Sponsell | Bleb drainage device, ophthalmological product and methods |
US9701940B2 (en) | 2005-09-19 | 2017-07-11 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
US9861465B2 (en) | 2010-09-22 | 2018-01-09 | Nanyang Technological University | Method for forming a tissue construct and use thereof |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US10265155B2 (en) | 2007-02-12 | 2019-04-23 | The Trustees Of Columbia University In The City Of New York | Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement |
US10806942B2 (en) | 2016-11-10 | 2020-10-20 | Qoravita LLC | System and method for applying a low frequency magnetic field to biological tissues |
US20200397559A1 (en) * | 2015-11-12 | 2020-12-24 | Biostage, Inc. | Systems and methods for producing gastrointestinal tissues at an anastomosis or other physiological location |
US11110199B2 (en) | 2013-04-12 | 2021-09-07 | The Trustees Of Columbia University In The City Of New York | Methods for host cell homing and dental pulp regeneration |
US11111470B2 (en) | 2019-02-05 | 2021-09-07 | Corning Incorporated | Packed-bed bioreactor systems and methods of using the same |
US11118151B2 (en) | 2019-11-05 | 2021-09-14 | Corning Incorporated | Fixed bed bioreactor and methods of using the same |
US11471285B2 (en) * | 2013-12-30 | 2022-10-18 | New York Stem Cell Foundation, Inc. | Tissue grafts and methods of making and using the same |
US11566215B2 (en) | 2016-08-27 | 2023-01-31 | 3D Biotek Llc | Bioreactor with scaffolds |
US11827873B2 (en) | 2016-11-09 | 2023-11-28 | Univercells Technologies S.A. | Cell growth matrix |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050084962A1 (en) * | 2003-08-20 | 2005-04-21 | Bruce Simon | Methods of treatment using electromagnetic field stimulated stem cells |
US8043614B2 (en) * | 2004-03-09 | 2011-10-25 | Ahlfors Jan-Eric W | Autogenic living scaffolds and living tissue matrices: methods and uses thereof |
CA2559275C (en) | 2004-03-09 | 2020-02-18 | Jan-Eric W. Ahlfors | Autogenic living scaffolds and living tissue matrices: methods and uses thereof |
US7662615B2 (en) * | 2004-07-27 | 2010-02-16 | Chung Yuan Christian University | System and method for cultivating cells |
US7718109B2 (en) | 2005-02-14 | 2010-05-18 | Mayo Foundation For Medical Education And Research | Tissue support structure |
US20090155332A1 (en) * | 2005-02-25 | 2009-06-18 | Eugene Sherry | Replacement bone tissue |
EP1863547B1 (en) * | 2005-03-11 | 2016-05-11 | Wake Forest University Health Sciences | Tissue engineered blood vessels |
JP4975013B2 (en) | 2005-03-11 | 2012-07-11 | ウエイク・フオレスト・ユニバーシテイ・ヘルス・サイエンシズ | Manufacture of heart valves with engineered tissue |
US20060204445A1 (en) * | 2005-03-11 | 2006-09-14 | Anthony Atala | Cell scaffold matrices with image contrast agents |
US20060204539A1 (en) * | 2005-03-11 | 2006-09-14 | Anthony Atala | Electrospun cell matrices |
US7531503B2 (en) * | 2005-03-11 | 2009-05-12 | Wake Forest University Health Sciences | Cell scaffold matrices with incorporated therapeutic agents |
WO2006104901A2 (en) * | 2005-03-28 | 2006-10-05 | University Of Florida Research Foundation, Inc. | Materials and methods for improved tissue engineering |
US7840272B2 (en) | 2005-06-03 | 2010-11-23 | Medrelief Inc. | Methods for modulating osteochondral development using bioelectrical stimulation |
ES2628031T3 (en) * | 2005-10-26 | 2017-08-01 | Genesis Technologies Limited | Bioabsorbable acellular tissue regeneration matrices produced by incubation of acellular blood products |
EP2605018A1 (en) * | 2006-03-09 | 2013-06-19 | The Trustees of the Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
WO2008069761A1 (en) * | 2006-12-05 | 2008-06-12 | Nanyang Technological University | Manufacturing three-dimensional scaffolds using cryogenic prototyping |
WO2008069760A1 (en) | 2006-12-05 | 2008-06-12 | Nanyang Technological University | Three-dimensional porous hybrid scaffold and manufacture thereof |
EP1990402A1 (en) * | 2007-05-07 | 2008-11-12 | ETH Zürich | Bioreactor to apply mechanical forces as an anabolic stimulus |
NL2002742C2 (en) * | 2009-04-09 | 2010-10-12 | Univ Delft Tech | Mechanical device for tissue regeneration. |
EP2606347A4 (en) * | 2010-08-20 | 2014-05-21 | Univ California | Small molecule arrays and methods for making and using them |
EP3798226A1 (en) | 2013-02-01 | 2021-03-31 | Children's Medical Center Corporation | Collagen scaffolds |
US10092679B2 (en) | 2013-10-18 | 2018-10-09 | Wake Forest University Health Sciences | Laminous vascular constructs combining cell sheet engineering and electrospinning technologies |
US20180303974A1 (en) | 2015-11-03 | 2018-10-25 | Ariel-University Research And Development Company Ltd. | Compositions for regeneration and repair of neural tissue |
US11638645B2 (en) * | 2016-05-19 | 2023-05-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biomimetic plywood motifs for bone tissue engineering |
CN107137763B (en) * | 2017-05-04 | 2020-05-22 | 宁夏医科大学 | Vascularized tissue engineering bone and preparation method thereof |
EP3929281A1 (en) | 2020-06-24 | 2021-12-29 | Fachhochschule Technikum Wien | Cell construct comprising schwann cells or schwann cell-like cells and a biocompatible matrix |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770417A (en) | 1986-11-20 | 1998-06-23 | Massachusetts Institute Of Technology Children's Medical Center Corporation | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
US20040158289A1 (en) | 2002-11-30 | 2004-08-12 | Girouard Steven D. | Method and apparatus for cell and electrical therapy of living tissue |
US20040158290A1 (en) | 2002-11-30 | 2004-08-12 | Girouard Steven D. | Method and apparatus for cell and electrical therapy of living tissue |
-
2002
- 2002-07-08 US US10/190,874 patent/US6995013B2/en active Active - Reinstated
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770417A (en) | 1986-11-20 | 1998-06-23 | Massachusetts Institute Of Technology Children's Medical Center Corporation | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
US20040158289A1 (en) | 2002-11-30 | 2004-08-12 | Girouard Steven D. | Method and apparatus for cell and electrical therapy of living tissue |
US20040158290A1 (en) | 2002-11-30 | 2004-08-12 | Girouard Steven D. | Method and apparatus for cell and electrical therapy of living tissue |
Non-Patent Citations (3)
Title |
---|
Bioelectromagnetics, "," Bioelectromagnetics, No. 20, p. 177-182, ( Sep. 30, 1999). |
Journal of Othopedic Research, "," Journal of Orthopedic Research, No. 2, p. 286-293, ( Mar. 30, 2001). |
Yost, MJ et al., "Design and Construction of a Uniaxial Cell Stretcher," Am J Physiol Heart Circ Physiol, No. 279, p. H3124-3130, ( Sep. 30, 2000). |
Cited By (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060094112A1 (en) * | 2001-03-07 | 2006-05-04 | Omotunde Babalola | Biological scaffold |
US20030232071A1 (en) * | 2002-04-18 | 2003-12-18 | Gower Laurie B. | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
US20060204581A1 (en) * | 2002-04-18 | 2006-09-14 | Gower Laurie B | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
US7455854B2 (en) | 2002-04-18 | 2008-11-25 | University Of Florida Research Foundation, Inc. | Method for producing a mineral fiber |
US20050152990A1 (en) * | 2002-04-18 | 2005-07-14 | Gower Laurie B. | Fibrous minerals, methods for their production using a solution-precursor-solid mechanism, and methods of use |
US7544496B2 (en) | 2002-04-18 | 2009-06-09 | University Of Florida Research Foundation, Inc. | Process for making organic/inorganic composites |
US20040131562A1 (en) * | 2002-04-18 | 2004-07-08 | Gower Laurie B. | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
US20060204580A1 (en) * | 2002-04-18 | 2006-09-14 | Gower Laurie B | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
US7547449B2 (en) | 2002-04-18 | 2009-06-16 | University Of Florida Research Foundation, Inc. | Method for treating a bone defect with an organic/inorganic composite |
US7514248B2 (en) | 2002-04-18 | 2009-04-07 | University Of Florida Research Foundation, Inc. | Process for making organic/inorganic composites |
US7514249B2 (en) * | 2002-04-18 | 2009-04-07 | The University Of Florida Research Foundation, Inc. | Biomimetic organic/inorganic composites |
US20080133008A1 (en) * | 2003-04-29 | 2008-06-05 | Muscuoskeletal Transplant Foundation | Cartilage repair mixture containing allograft chondrocytes |
USRE42208E1 (en) | 2003-04-29 | 2011-03-08 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
USRE43258E1 (en) | 2003-04-29 | 2012-03-20 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US20050049640A1 (en) * | 2003-05-12 | 2005-03-03 | Gurtner Geoffrey C. | Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2 |
US8221500B2 (en) | 2003-05-16 | 2012-07-17 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20040230303A1 (en) * | 2003-05-16 | 2004-11-18 | Gomes Katherine A. | Cartilage allograft plug |
US8142774B2 (en) | 2003-08-20 | 2012-03-27 | Ebi, Llc | Methods of treatment using electromagnetic field stimulated stem cells |
US7744869B2 (en) | 2003-08-20 | 2010-06-29 | Ebi, Llc | Methods of treatment using electromagnetic field stimulated mesenchymal stem cells |
US20060057693A1 (en) * | 2003-08-20 | 2006-03-16 | Ebi, L.P. | Methods of treatment using electromagnetic field stimulated stem cells |
US20100239544A1 (en) * | 2003-08-20 | 2010-09-23 | Ebi, Llc | Methods of treatment using electromagnetic field stimulated stem cells |
US20090319045A1 (en) * | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US8292968B2 (en) | 2004-10-12 | 2012-10-23 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US20140371869A1 (en) * | 2005-03-11 | 2014-12-18 | Wake Forest University Health Sciences | Production of tissue engineered digits and limbs |
US9039782B2 (en) * | 2005-03-11 | 2015-05-26 | Wake Forest University Health Sciences | Production of tissue engineered digits and limbs |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
US20070009610A1 (en) * | 2005-07-11 | 2007-01-11 | Carina Syring | Engineered osteochondral construct for treatment of articular cartilage defects |
US9701940B2 (en) | 2005-09-19 | 2017-07-11 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
US20070105769A1 (en) * | 2005-11-07 | 2007-05-10 | Ebi, L.P. | Methods of treating tissue defects |
US8906110B2 (en) | 2007-01-24 | 2014-12-09 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US10265155B2 (en) | 2007-02-12 | 2019-04-23 | The Trustees Of Columbia University In The City Of New York | Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US20100015202A1 (en) * | 2007-03-06 | 2010-01-21 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US20080217263A1 (en) * | 2007-03-06 | 2008-09-11 | Biomet Biologics, Inc. | Angiogenesis initation and growth |
US8663146B2 (en) | 2007-03-06 | 2014-03-04 | Biomet Biologics, Llc | Angiogenesis initiation and growth |
US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
US9352002B2 (en) | 2007-03-06 | 2016-05-31 | Biomet Biologics, Llc | Angiogenesis initiation and growth |
US20080248572A1 (en) * | 2007-04-06 | 2008-10-09 | Gambro Bct, Inc. | Bioreactor Surfaces |
EP3128015A2 (en) | 2007-05-29 | 2017-02-08 | Christopher B. Reid | A method for providing a desired cell population capable of further differentiation in vivo |
WO2008150814A2 (en) | 2007-05-29 | 2008-12-11 | Reid Christopher B | Methods for production and uses of multipotent cell populations |
WO2008153968A2 (en) | 2007-06-07 | 2008-12-18 | Wake Forest University Health Sciences | Inkjet gene printing |
US8167955B2 (en) | 2008-03-28 | 2012-05-01 | The University Of Kentucky Research Foundation | Carbon fiber reinforced carbon foams for repair and reconstruction of bone defects |
US20090248047A1 (en) * | 2008-03-28 | 2009-10-01 | Marrs Brock H | Carbon fiber reinforced carbon foams for repair and reconstruction of bone defects |
US8808725B2 (en) | 2008-11-20 | 2014-08-19 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US20100274362A1 (en) * | 2009-01-15 | 2010-10-28 | Avner Yayon | Cartilage particle tissue mixtures optionally combined with a cancellous construct |
US8790681B2 (en) * | 2009-06-15 | 2014-07-29 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US10702627B2 (en) * | 2009-06-15 | 2020-07-07 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US8802115B2 (en) | 2009-06-15 | 2014-08-12 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US20150134065A1 (en) * | 2009-06-15 | 2015-05-14 | Cartiheal (2009) Ltd | Mulit-Phasic Solid Implants for Tissue Repair |
US20210077657A1 (en) * | 2009-06-15 | 2021-03-18 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
AU2010261389B2 (en) * | 2009-06-15 | 2016-03-03 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US20140287017A1 (en) * | 2009-06-15 | 2014-09-25 | Cartiheal (2009) Ltd. | Solid Forms for Tissue Repair |
US10271938B2 (en) * | 2009-06-15 | 2019-04-30 | Cartiheal (2009) Ltd | Multi-phasic solid implants for tissue repair |
US20120177702A1 (en) * | 2009-06-15 | 2012-07-12 | Cartiheal (2009) Ltd. | Solid Forms for Tissue Repair |
US20190070333A1 (en) * | 2009-06-15 | 2019-03-07 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US20180339081A1 (en) * | 2009-06-15 | 2018-11-29 | Cartiheal (2009) Ltd. | Solid Forms For Tissue Repair |
US10046084B2 (en) | 2009-06-15 | 2018-08-14 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US10080818B2 (en) * | 2009-06-15 | 2018-09-25 | Cartiheal (2009) Ltd. | Solid forms for tissue repair |
US20110172611A1 (en) * | 2010-01-08 | 2011-07-14 | Yoo James J | Delivery system |
US10500384B2 (en) | 2010-01-08 | 2019-12-10 | Wake Forest University Health Sciences | Delivery system |
US20120028275A1 (en) * | 2010-07-27 | 2012-02-02 | Gambro Lundia Ab | Biomimetic membrane for cell expansion |
US9861465B2 (en) | 2010-09-22 | 2018-01-09 | Nanyang Technological University | Method for forming a tissue construct and use thereof |
WO2012122105A1 (en) | 2011-03-07 | 2012-09-13 | Wake Forest University Health Sciences | Delivery system |
US10118005B2 (en) | 2011-03-07 | 2018-11-06 | Wake Forest University Health Sciences | Delivery system |
US10537689B2 (en) | 2011-03-07 | 2020-01-21 | Wake Forest University Health Sciences | Delivery system |
US11759579B2 (en) | 2011-03-07 | 2023-09-19 | Wake Forest University Health Sciences | Delivery system |
US9381112B1 (en) | 2011-10-06 | 2016-07-05 | William Eric Sponsell | Bleb drainage device, ophthalmological product and methods |
US11065154B1 (en) | 2011-10-06 | 2021-07-20 | William Eric Sponsel | Bleb drainage device, ophthalmic product and methods |
US8632489B1 (en) | 2011-12-22 | 2014-01-21 | A. Mateen Ahmed | Implantable medical assembly and methods |
US11110199B2 (en) | 2013-04-12 | 2021-09-07 | The Trustees Of Columbia University In The City Of New York | Methods for host cell homing and dental pulp regeneration |
US11471285B2 (en) * | 2013-12-30 | 2022-10-18 | New York Stem Cell Foundation, Inc. | Tissue grafts and methods of making and using the same |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US11555172B2 (en) | 2014-12-02 | 2023-01-17 | Ocugen, Inc. | Cell and tissue culture container |
US20200397559A1 (en) * | 2015-11-12 | 2020-12-24 | Biostage, Inc. | Systems and methods for producing gastrointestinal tissues at an anastomosis or other physiological location |
US11566215B2 (en) | 2016-08-27 | 2023-01-31 | 3D Biotek Llc | Bioreactor with scaffolds |
US11926810B2 (en) | 2016-08-27 | 2024-03-12 | 3D Biotek, Llc | Bioreactor with scaffolds |
US11827873B2 (en) | 2016-11-09 | 2023-11-28 | Univercells Technologies S.A. | Cell growth matrix |
US11344741B2 (en) | 2016-11-10 | 2022-05-31 | Qoravita LLC | System and method for applying a low frequency magnetic field to biological tissues |
US10806942B2 (en) | 2016-11-10 | 2020-10-20 | Qoravita LLC | System and method for applying a low frequency magnetic field to biological tissues |
US11826579B2 (en) | 2016-11-10 | 2023-11-28 | Mannavibes Inc. | System and method for applying a low frequency magnetic field to biological tissues |
US11920117B2 (en) | 2019-02-05 | 2024-03-05 | Corning Incorporated | Woven cell culture substrates, bioreactor systems using the same, and related methods |
US11434460B2 (en) | 2019-02-05 | 2022-09-06 | Corning Incorporated | Woven cell culture substrates, bioreactor systems using the same, and related methods |
US11401493B2 (en) | 2019-02-05 | 2022-08-02 | Corning Incorporated | Packed-bed bioreactor systems and methods of using the same |
US11111470B2 (en) | 2019-02-05 | 2021-09-07 | Corning Incorporated | Packed-bed bioreactor systems and methods of using the same |
US11639489B2 (en) | 2019-02-05 | 2023-05-02 | Corning Incorporated | Packed-bed bioreactor systems and methods of using the same |
US11661576B2 (en) | 2019-02-05 | 2023-05-30 | Corning Incorporated | Packed-bed bioreactor systems and methods of using the same |
US11692161B2 (en) | 2019-02-05 | 2023-07-04 | Corning Incorporated | Packed-bed bioreactor systems and methods of using the same |
US11118151B2 (en) | 2019-11-05 | 2021-09-14 | Corning Incorporated | Fixed bed bioreactor and methods of using the same |
US11795426B2 (en) | 2019-11-05 | 2023-10-24 | Corning Incorporated | Fixed bed bioreactor and methods of using the same |
Also Published As
Publication number | Publication date |
---|---|
US20040005297A1 (en) | 2004-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6995013B2 (en) | Cell-scaffold composition containing five layers | |
US20060094112A1 (en) | Biological scaffold | |
Sharma et al. | Engineering structurally organized cartilage and bone tissues | |
EP2522304B1 (en) | Composition and methods for the production of biological tissues and tissue constructs | |
EP0739631B1 (en) | Laminar bone support for cartilage growth | |
Hillsley et al. | Bone tissue engineering: the role of interstitial fluid flow | |
US20180008747A1 (en) | Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal | |
Melek | Tissue engineering in oral and maxillofacial reconstruction | |
US20050002910A1 (en) | Vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby | |
Yuste et al. | Mimicking bone microenvironment: 2D and 3D in vitro models of human osteoblasts | |
AU2002306835A1 (en) | Composition and Methods for the Production of Biological Tissues and Tissue Constructs | |
Harris et al. | Strategies to direct angiogenesis within scaffolds for bone tissue engineering | |
US20040096430A1 (en) | Method and device for producing biological tissue in a growth chamber | |
Rosa et al. | Macroporous scaffolds associated with cells to construct a hybrid biomaterial for bone tissue engineering | |
JP4122280B2 (en) | Manufacturing method of tissue plug | |
Corsi et al. | Regenerative medicine in orthopaedic surgery | |
Martin et al. | Producing prefabricated tissues and organs via tissue engineering | |
Bara et al. | Engineering functional tissues: in vitro culture parameters | |
AU2003294621A1 (en) | Method for the treatment of diseased, degenerated, or damaged tissue using three-dimensional tissue produced in vitro in combination with tissue cells and/or exogenic factors | |
Alvarez-Barreto et al. | Tissue engineering bioreactors | |
Sarraf et al. | Tissue engineering of biological cardiovascular system surrogates | |
KUBOKI et al. | New principles of regenerative medicine: with special reference to mechano-dynamic factors | |
RU2818176C1 (en) | Method for producing tissue-engineered periosteum from cell spheroids for repairing bone defects in patients | |
Wiesmann et al. | Tissue engineering of bone | |
Obradovic et al. | Tissue engineering of cartilage and myocardium |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BIOMED SOLUTIONS, LLC, NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CONNELLY, PATRICK R.;REEL/FRAME:013227/0336 Effective date: 20020703 |
|
AS | Assignment |
Owner name: BIOMED SOLUTIONS, LLC, NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BABALOLA, OMOTUNDE M.;REEL/FRAME:013575/0672 Effective date: 20020830 |
|
FEPP | Fee payment procedure |
Free format text: PAYER NUMBER DE-ASSIGNED (ORIGINAL EVENT CODE: RMPN); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
REMI | Maintenance fee reminder mailed | ||
FEPP | Fee payment procedure |
Free format text: PETITION RELATED TO MAINTENANCE FEES FILED (ORIGINAL EVENT CODE: PMFP); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY Free format text: PETITION RELATED TO MAINTENANCE FEES GRANTED (ORIGINAL EVENT CODE: PMFG); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
LAPS | Lapse for failure to pay maintenance fees | ||
REIN | Reinstatement after maintenance fee payment confirmed | ||
PRDP | Patent reinstated due to the acceptance of a late maintenance fee |
Effective date: 20140328 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20140207 |
|
FEPP | Fee payment procedure |
Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.) |
|
FEPP | Fee payment procedure |
Free format text: 11.5 YR SURCHARGE- LATE PMT W/IN 6 MO, SMALL ENTITY (ORIGINAL EVENT CODE: M2556) |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 12TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2553) Year of fee payment: 12 |