US7364588B2 - Device, assembly and method for mitral valve repair - Google Patents

Device, assembly and method for mitral valve repair Download PDF

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US7364588B2
US7364588B2 US10/912,735 US91273504A US7364588B2 US 7364588 B2 US7364588 B2 US 7364588B2 US 91273504 A US91273504 A US 91273504A US 7364588 B2 US7364588 B2 US 7364588B2
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mitral valve
heart
anchor
valve annulus
orientation
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US20050065598A1 (en
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Mark L. Mathis
Gregory Nieminen
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Cardiac Dimensions Pty Ltd
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Cardiac Dimensions Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2451Inserts in the coronary sinus for correcting the valve shape
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902Method of implanting
    • Y10S623/904Heart

Definitions

  • the present invention generally relates to a device, assembly and method for treating dilated cardiomyopathy of a heart.
  • the present invention more particularly relates to mitral valve annulus device, assembly, and method wherein the device is flexible when in a first orientation to conform to the coronary sinus adjacent the mitral valve annulus and relatively rigid when rotated into a second orientation to reshape the mitral valve annulus.
  • the human heart generally includes four valves. Of these valves, a most critical one is known as the mitral valve.
  • the mitral valve is located in the left atrial ventricular opening between the left atrium and left ventricle.
  • the mitral valve is intended to prevent regurgitation of blood from the left ventricle into the left atrium when the left ventricle contracts. In preventing blood regurgitation the mitral valve must be able to withstand considerable back pressure as the left ventricle contracts.
  • the valve cusps of the mitral valve are anchored to muscular wall of the heart by delicate but strong fibrous cords in order to support the cusps during left ventricular contraction.
  • the geometry of the mitral valve ensures that the cusps overlie each other to preclude regurgitation of the blood during left ventricular contraction.
  • the normal functioning of the mitral valve in preventing regurgitation can be impaired by dilated cardiomyopathy caused by disease or certain natural defects.
  • certain diseases may cause dilation of the mitral valve annulus. This can result in deformation of the mitral valve geometry to cause ineffective closure of the mitral valve during left ventricular contraction. Such ineffective closure results in leakage through the mitral valve and regurgitation.
  • Diseases such as bacterial inflammations of the heart or heart failure can cause the aforementioned distortion or dilation of the mitral valve annulus. Needless to say, mitral valve regurgitation must not go uncorrected.
  • One method of repairing a mitral valve having impaired function is to completely replace the valve. This method has been found to be particularly suitable for replacing a mitral valve when one of the cusps has been severely damaged or deformed. While the replacement of the entire valve eliminates the immediate problem associated with a dilated mitral valve annulus, presently available prosthetic heart valves do not possess the same durability as natural heart valves.
  • prostheses are annular or partially annular shaped members which fit about the base of the valve annulus.
  • the annular or partially annular shaped members may be formed from a rigid material, such as a metal, or from a flexible material.
  • coronary sinus of a heart is near to and at least partially encircles the mitral valve annulus and then extends into a venous system including the great cardiac vein.
  • coronary sinus is meant to refer to not only the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein.
  • the therapy contemplates the use of a device introduced into the coronary sinus to reshape and advantageously effect the geometry of the mitral valve annulus.
  • the device includes a resilient member having a cross sectional dimension for being received within the coronary sinus of the heart and a longitudinal dimension having an unstressed arched configuration when placed in the coronary sinus.
  • the device partially encircles and exerts an inward pressure on the mitral valve.
  • the inward pressure constricts the mitral valve annulus, or at least a portion of it, to essentially restore the mitral valve geometry. This promotes effective valve sealing action and eliminates mitral regurgitation.
  • the device may be implanted in the coronary sinus using only percutaneous techniques similar to the techniques used to implant cardiac leads such as pacemaker leads.
  • One proposed system for implanting the device includes an elongated introducer configured for being releasably coupled to the device.
  • the introducer is preferably flexible to permit it to advance the device into the heart and into the coronary sinus through the coronary sinus ostium.
  • an elongated sheath is first advanced into the coronary sinus. Then, the device and introducer are moved through a lumen of the sheath until the device is in position within the coronary sinus. Because the device is formed of resilient material, it conforms to the curvatures of the lumen as it is advanced through the sheath.
  • the sheath is then partially retracted to permit the device to assume its unstressed arched configuration.
  • the introducer is then decoupled from the device and retracted through the sheath.
  • the procedure is then completed by the retraction of the sheath.
  • the device is left within the coronary sinus to exert the inward pressure on the mitral valve to restore mitral valve geometry.
  • mitral valve regurgitation may be treated at an early stage in the mitral regurgitation progression. Further, the device may be placed with relative ease by any minimally invasive cardiologist. Still further, since the heart remains completely intact throughout the procedure, the effectiveness of the procedure may be readily determined. Moreover, should adjustments be deemed desirable, such adjustments may be made during the procedure and before the patient is sent to recovery.
  • mitral regurgitation with a device in the coronary sinus is based upon the observation that the application of a localized force against a discrete portion of the mitral valve annulus can terminate mitral regurgitation. This suggests that mitral regurgitation may be localized and nonuniform.
  • the device applies a force to one or more discrete portions of the atrial wall of the coronary sinus to provide localized mitral valve annulus reshaping instead of generalized reshaping of the mitral valve annulus.
  • Such localized therapy would have all the benefits of the generalized therapy.
  • a localized therapy device may be easier to implant and adjust.
  • a still further approach to treat mitral regurgitation from the coronary sinus of the heart contemplates a device having a first anchor configured to be positioned within and fixed to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a cable fixed to the first anchor and extending proximally from the first anchor within the heart, a second anchor configured to be positioned in and fixed in the heart proximal to the first anchor and arranged to slidingly receive the cable, and a lock that locks the cable on the second anchor.
  • the cable may be drawn proximally and locked on the second anchor.
  • the geometry of the mitral valve is thereby effected.
  • This approach provides flexibility in that the second anchor may be positioned and fixed in the coronary sinus or alternatively, the second anchor may be positioned and fixed in the right atrium. This approach further allows adjustments in the cable tension after implant.
  • a still further alternative for treating mitral regurgitation contemplates a device having a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart.
  • a second anchor is configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart.
  • a connecting member having a fixed length, is permanently attached to the first and second anchors.
  • a further approach uses staple devices for effecting mitral valve annulus geometry of a heart.
  • the staples are carried in an elongated catheter placeable in the coronary sinus of the heart adjacent the mitral valve annulus.
  • the staples include first and second leg portions, each leg portion terminating in a tissue piercing end, and a connection portion extending between the first and second leg portions.
  • the connection portions have an initial stressed and distorted configuration to separate the first and second leg portions by a first distance when the tissue piercing ends pierce the mitral valve annulus and a final unstressed and undistorted configuration after the tissue piercing ends pierce the mitral valve annulus to separate the first and second leg portions by a second distance, the second distance being shorter than the first distance.
  • a tool forces the staples from the catheter to cause the tissue piercing ends of the first and second leg portions to pierce the mitral valve annulus with the connection portion of the at least one staple in the initial configuration.
  • the catheter includes a tubular wall having break-away slots adjacent the staples to permit the staples to be forced from the catheter into the adjacent tissue.
  • the present invention provides a still further approach for effecting mitral valve annulus geometry of a heart.
  • the invention provides a device that effects the condition of a mitral valve annulus of a heart.
  • the device includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus, the elongated member having a relatively low resistance to flexure in a first direction and a relatively high resistance to flexure n a second direction.
  • the first and second directions may lie in the same plane.
  • the elongated member may include a first longitudinal side facing the first direction and a first plurality of notches formed in the first longitudinal side to provide the elongated member with the relatively low resistance to flexure in the first direction.
  • the elongated member may also include a second longitudinal side facing the second direction and a second plurality of notches formed in the second longitudinal side to render the elongated member stable when flexed in the second direction.
  • the first plurality of notches are preferably larger than the second plurality of notches.
  • the elongated member also has first and second ends and an anchor at each end that fix the device in the coronary sinus.
  • each anchor anchors the device against longitudinal movement and rotational movement.
  • the invention further provides a device that effects the condition of a mitral valve annulus of a heart including an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus.
  • the elongated member is flexible when placed in the heart in a first orientation to position the device in the coronary sinus adjacent the mitral valve annulus and relatively inflexible when rotated into a second orientation after the device is positioned in the coronary sinus adjacent to the mitral valve annulus.
  • the elongated member has a first radius of curvature when in the first orientation and a second radius of curvature when in the second orientation.
  • the first radius of curvature is less than the second radius of curvature.
  • the invention still further provides a method of effecting the condition of a mitral valve annulus of a heart.
  • the method includes the steps of providing a mitral valve annulus therapy device including an elongated member that is flexible when placed in the heart in a first orientation and relatively inflexible when rotated into a second orientation, advancing the device into the coronary sinus of the heart with the device in the first orientation until the device is adjacent the mitral valve annulus within the coronary sinus, and rotating the device into the second orientation.
  • the method may further include the step of anchoring the device in the coronary sinus.
  • the device is preferably anchored against at least rotational movement.
  • the invention still further provides an assembly that effects the condition of a mitral valve annulus of a heart.
  • the assembly includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent to the mitral valve annulus.
  • the elongated member is flexible when placed in the heart in a first orientation to conform to the coronary sinus and relatively inflexible when rotated into a second orientation.
  • the assembly further includes a push member configured to be releasably coupled to the elongated member that advances the elongated member into the coronary sinus adjacent to the mitral valve annulus.
  • the push member rotates the elongated member into the second orientation upon rotation of the push member.
  • a U-joint releasably couples the elongated member to the push member.
  • the assembly may further include a flexible catheter having a lumen that receives the elongated member and push member to guide the elongated member into the coronary sinus.
  • the elongated member may be rotated into the second orientation upon rotation of the catheter.
  • the push member may be released from the elongated member with proximal movement of the catheter.
  • the elongated member has a first radius of curvature when in the first orientation and a second radius of curvature when in the second orientation.
  • the first radius of curvature is less than the second radius of curvature.
  • the elongated member also may have an anchor at each end that fix the device in the coronary sinus.
  • the anchors preferably anchor the device against both longitudinal and rotational movement.
  • FIG. 1 is a superior view of a human heart with the atria removed;
  • FIG. 2 is a side plan view of a mitral valve therapy device embodying the present invention
  • FIG. 3 is a side plan view to an enlarged scale of a portion of the device of FIG. 2 ;
  • FIG. 4 is a partial superior view of a human heart illustrating a first step in the deployment of the mitral valve therapy device embodying the present invention
  • FIG. 5 is a view similar to FIG. 4 illustrating a further step in the deployment of the mitral valve therapy device
  • FIG. 6 is a superior view of a human heart similar to FIG. 4 illustrating the mitral valve therapy device deployed and anchored in the heart;
  • FIG. 7 is a partial perspective view of a coupling arrangement between the mitral valve therapy device and a deployment tool in accordance with an embodiment of the present invention.
  • FIG. 8 is a partial perspective view illustrating the release of the coupling arrangement of FIG. 7 .
  • FIG. 1 it is a superior view of a human heart 10 with the atria removed to expose the mitral valve 12 , the coronary sinus 14 , the coronary artery 15 , and the circumflex artery 17 of the heart 10 to lend a better understanding of the present invention. Also generally shown in FIG. 1 are the pulmonary valve 22 , the aortic valve 24 , and the tricuspid valve 26 of the heart 10 .
  • the mitral valve 12 includes an anterior cusp 16 , a posterior cusp 18 and an annulus 20 .
  • the annulus encircles the cusps 16 and 18 and maintains their spacing to provide a complete closure during a left ventricular contraction.
  • the coronary sinus 14 partially encircles the mitral valve 12 adjacent to the mitral valve annulus 20 .
  • the coronary sinus is part of the venus system of the heart and extends along the AV groove between the left atrium and the left ventricle. This places the coronary sinus essentially within the same plane as the mitral valve annulus making the coronary sinus available for placement of the mitral valve therapy device of the present invention therein.
  • FIG. 2 shows a mitral valve therapy device 30 embodying the present invention.
  • the device 30 takes the form of an elongated tubular member 32 which includes a distal anchor 34 , a proximal anchor 36 , a coupler 38 , and a therapy section 40 .
  • the anchors 34 and 36 are shown in FIG. 2 in their predeployed configuration. As will be seen hereinafter, upon deployment of the device 30 in the coronary sinus, the anchors expand outwardly in a toggle bolt manner to anchor the device in the coronary sinus against both longitudinal and rotational movement. To that end, at least the anchors 34 and 36 are formed from a material, such as Nitinol, having shape memory to implement their expansion. The rest of the device 30 may also be formed from Nitinol or other non-rigid biocompatible materials such as stainless steel.
  • the coupler 38 releasably couples the device to a deployment tool to be described hereinafter during the implant and deployment of the device 30 .
  • the coupler forms with the deployment tool a U-joint to permit flexibility.
  • the deployment tool includes a complementary coupler with shape memory for releasing the deployment tool from the elongated member 32 .
  • FIG. 3 shows a portion of the therapy section 40 in greater detail.
  • the elongated member 32 within the therapy section 40 , is configured to permit a first flexibility in the elongated member when bent in a first direction and a second and less flexibility in the elongated member 32 when bent in a second direction. More specifically, the elongated member 32 includes a first plurality of slots or notches 42 along a side thereof and a second plurality of slots or notches 44 along an opposite side thereof.
  • the first plurality of notches 42 render the elongated member flexible for bending in the first direction as indicated by arrows 46 and the second plurality of notches 44 render the elongated member flexible for bending in the second direction as indicate by arrows 48 .
  • the first plurality of notches 42 are wider or larger than the second plurality of notches 44 so that the elongated member 32 has a relatively low resistance to flexure or bending in the first direction 46 and a relatively high resistance to flexure or bending in the second direction 48 .
  • the relative resistances to flexure allow the device 30 to be readily positioned in the coronary sinus of the heart and then deployed. While in a first orientation, with the first plurality of notches adjacent the mitral valve annulus, the device 30 , as it is advanced into the coronary sinus, is permitted to bend and conform to the shape of the coronary sinus. Once properly positioned in the coronary sinus adjacent the mitral valve annulus, the device may be rotated into a second orientation wherein the second plurality of notches 44 are adjacent to the mitral valve annulus. The device 30 may be rotated by either rotating the deployment tool or by rotating a deployment catheter, to be described hereinafter, in which the device resides and which may be used to guide the device 30 into the proper position within the coronary sinus. Once rotated into the second orientation, the elongated member 32 will substantially straighten to act upon and increase the radius of curvature of the adjacent mitral valve annulus.
  • the second plurality of slots 44 permit slight bending of the elongated member towards the mitral valve annulus to render the device stable in the second orientation. Were the device not permitted to bend slightly towards the mitral valve annulus while in the second orientation, the device could revert to the then more stable first orientation away from the mitral valve annulus.
  • FIGS. 4-6 illustrate the deployment of the device 30 in accordance with an embodiment of the present invention.
  • FIG. 4 illustrates an assembly 28 , including the device 30 , for effecting the geometry of the mitral valve annulus 20 .
  • the assembly is illustrated in an initial stage of deploying the device 30 .
  • the assembly includes the device 30 , a deployment catheter 50 , and the deployment tool or push member 52 .
  • the distal end of the push member 52 is coupled to the coupler 38 of the device 30 .
  • Both the device 30 and push member 52 are within a lumen 54 of the deployment catheter 50 which is dimensioned to permit the device 30 and push member 52 to be advanced down into the coronary sinus in which the catheter 50 is already positioned.
  • the device 30 As the device 30 is advanced into the coronary sinus and adjacent the mitral valve annulus, the device is disposed in the first orientation with the first plurality of notches 42 adjacent the mitral valve annulus 20 . This permits the device 30 to bend with relatively low resistance to flexure to conform to the shape of the coronary sinus with a first radius of curvature. As a result, the device 30 may be readily positioned adjacent the mitral valve annulus 20 .
  • the device 30 With the device 30 positioned in the coronary sinus 14 adjacent the mitral valve annulus 20 as illustrated in FIG. 4 , the device may now be rotated into the second orientation as illustrated in FIG. 5 .
  • the second orientation In the second orientation, the second plurality of notches or slots 44 are now adjacent the mitral valve annulus. Because the second plurality of notches are relatively narrow, the higher resistance of flexure of the device in the second orientation will cause the device the substantially straighten to a second and increased radius of curvature. This causes the device to act upon the geometry of the mitral valve annulus 20 by increasing its radius of curvature as illustrated in FIG. 5 to treat and terminate mitral regurgitation, for example.
  • the device 30 may be rotated by rotating the deployment catheter 50 or by rotating the deployment tool 52 relative to the catheter 50 . This permits the assembly 28 to remain intact while the effectiveness of the device placement is evaluated. Should moving the device to a slightly different position be required, this may be accomplished by simply rotating the device back to the first orientation and repositioning the device with the deployment tool 52 .
  • the device 30 may now be fully deployed. To that end, the deployment catheter 50 is pulled proximally while the deployment tool or push member 52 is held stationary. This removes the catheter from the device 30 .
  • the distal anchor 34 is released to expand in a toggle bolt like manner and anchor the device against both longitudinal and rotational movement.
  • the distal anchor 34 is divided into a pair of sections 33 and 35 which are coupled together by a flexible coupling 37 . This enables the anchor 34 to better conform to the bend in the coronary sinus at this location of the heart.
  • proximal anchor 36 Further proximal movement of the deployment catheter 50 releases the proximal anchor 36 . It also expands in a toggle bolt like manner to anchor the device against both longitudinal and rotational movement.
  • FIG. 6 illustrates the device 30 fully deployed and anchored without the deployment catheter or deployment tool.
  • FIGS. 6 and 7 show the coupling and decoupling of the device 30 and the deployment tool or push member 52 in greater detail.
  • the coupler 38 is shown engaged with a complimentary coupler 58 of the deployment tool 52 .
  • the configuration of the couplers 38 and 58 form a U-joint allowing flexibility between the device 30 and the tool 52 .
  • the coupler 58 of the deployment tool 52 has shape memory for disengaging the coupler 38 of the device 30 when the catheter is moved sufficiently proximally to expose the couplers 38 and 58 . This is illustrated in FIG. 8 . Here it can be seen that the coupler 58 has sufficiently disengaged the coupler 38 of the device 30 to enable the deployment tool 52 to be removed from the patient with the fully deployed and anchored device 30 within the heart to provide its therapeutic effect as illustrated in FIG. 6 .

Abstract

A mitral valve therapy device effects the condition of a mitral valve annulus of a heart. The device includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus. The elongated member is flexible when placed in the heart in a first orientation to position the device in the coronary sinus adjacent the mitral valve annulus and relatively inflexible when rotated into a second orientation after the device is positioned in the coronary sinus adjacent to the mitral valve annulus to substantially straighten and increase the radius of curvature of the mitral valve annulus.

Description

CROSS-REFERENCE
This application is a continuation application of Ser. No. 10/095,507, filed Mar. 11, 2002 now U.S. Pat. No. 6,797,001, which is incorporated herein by reference in its entirety and to which application we claim priority under 35 USC § 120.
FIELD OF THE INVENTION
The present invention generally relates to a device, assembly and method for treating dilated cardiomyopathy of a heart. The present invention more particularly relates to mitral valve annulus device, assembly, and method wherein the device is flexible when in a first orientation to conform to the coronary sinus adjacent the mitral valve annulus and relatively rigid when rotated into a second orientation to reshape the mitral valve annulus.
BACKGROUND OF THE INVENTION
The human heart generally includes four valves. Of these valves, a most critical one is known as the mitral valve. The mitral valve is located in the left atrial ventricular opening between the left atrium and left ventricle. The mitral valve is intended to prevent regurgitation of blood from the left ventricle into the left atrium when the left ventricle contracts. In preventing blood regurgitation the mitral valve must be able to withstand considerable back pressure as the left ventricle contracts.
The valve cusps of the mitral valve are anchored to muscular wall of the heart by delicate but strong fibrous cords in order to support the cusps during left ventricular contraction. In a healthy mitral valve, the geometry of the mitral valve ensures that the cusps overlie each other to preclude regurgitation of the blood during left ventricular contraction.
The normal functioning of the mitral valve in preventing regurgitation can be impaired by dilated cardiomyopathy caused by disease or certain natural defects. For example, certain diseases may cause dilation of the mitral valve annulus. This can result in deformation of the mitral valve geometry to cause ineffective closure of the mitral valve during left ventricular contraction. Such ineffective closure results in leakage through the mitral valve and regurgitation. Diseases such as bacterial inflammations of the heart or heart failure can cause the aforementioned distortion or dilation of the mitral valve annulus. Needless to say, mitral valve regurgitation must not go uncorrected.
One method of repairing a mitral valve having impaired function is to completely replace the valve. This method has been found to be particularly suitable for replacing a mitral valve when one of the cusps has been severely damaged or deformed. While the replacement of the entire valve eliminates the immediate problem associated with a dilated mitral valve annulus, presently available prosthetic heart valves do not possess the same durability as natural heart valves.
Various other surgical procedures have been developed to correct the deformation of the mitral valve annulus and thus retain the intact natural heart valve function. These surgical techniques involve repairing the shape of the dilated or deformed valve annulus. Such techniques, generally known as annuloplasty, require surgically restricting the valve annulus to minimize dilation. Here, a prosthesis is typically sutured about the base of the valve leaflets to reshape the valve annulus and restrict the movement of the valve annulus during the opening and closing of the mitral valve.
Many different types of prostheses have been developed for use in such surgery. In general, prostheses are annular or partially annular shaped members which fit about the base of the valve annulus. The annular or partially annular shaped members may be formed from a rigid material, such as a metal, or from a flexible material.
While the prior art methods mentioned above have been able to achieve some success in treating mitral regurgitation, they have not been without problems and potential adverse consequences. For example, these procedures require open heart surgery. Such procedures are expensive, are extremely invasive requiring considerable recovery time, and pose the concomitant mortality risks associated with such procedures. Moreover, such open heart procedures are particularly stressful on patients with a comprised cardiac condition. Given these factors, such procedures are often reserved as a last resort and hence are employed late in the mitral regurgitation progression. Further, the effectiveness of such procedures is difficult to assess during the procedure and may not be known until a much later time. Hence, the ability to make adjustments to or changes in the prostheses to obtain optimum effectiveness is extremely limited. Later corrections, if made at all, require still another open heart surgery.
An improved therapy to treat mitral regurgitation without resorting to open heart surgery has recently been proposed. This is rendered possible by the realization that the coronary sinus of a heart is near to and at least partially encircles the mitral valve annulus and then extends into a venous system including the great cardiac vein. As used herein, the term “coronary sinus” is meant to refer to not only the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein. The therapy contemplates the use of a device introduced into the coronary sinus to reshape and advantageously effect the geometry of the mitral valve annulus.
The device includes a resilient member having a cross sectional dimension for being received within the coronary sinus of the heart and a longitudinal dimension having an unstressed arched configuration when placed in the coronary sinus. The device partially encircles and exerts an inward pressure on the mitral valve. The inward pressure constricts the mitral valve annulus, or at least a portion of it, to essentially restore the mitral valve geometry. This promotes effective valve sealing action and eliminates mitral regurgitation.
The device may be implanted in the coronary sinus using only percutaneous techniques similar to the techniques used to implant cardiac leads such as pacemaker leads. One proposed system for implanting the device includes an elongated introducer configured for being releasably coupled to the device. The introducer is preferably flexible to permit it to advance the device into the heart and into the coronary sinus through the coronary sinus ostium. To promote guidance, an elongated sheath is first advanced into the coronary sinus. Then, the device and introducer are moved through a lumen of the sheath until the device is in position within the coronary sinus. Because the device is formed of resilient material, it conforms to the curvatures of the lumen as it is advanced through the sheath. The sheath is then partially retracted to permit the device to assume its unstressed arched configuration. Once the device is properly positioned, the introducer is then decoupled from the device and retracted through the sheath. The procedure is then completed by the retraction of the sheath. As a result, the device is left within the coronary sinus to exert the inward pressure on the mitral valve to restore mitral valve geometry.
The foregoing therapy has many advantages over the traditional open heart surgery approach. Since the device, system and method may be employed in a comparatively noninvasive procedure, mitral valve regurgitation may be treated at an early stage in the mitral regurgitation progression. Further, the device may be placed with relative ease by any minimally invasive cardiologist. Still further, since the heart remains completely intact throughout the procedure, the effectiveness of the procedure may be readily determined. Moreover, should adjustments be deemed desirable, such adjustments may be made during the procedure and before the patient is sent to recovery.
Another approach to treat mitral regurgitation with a device in the coronary sinus is based upon the observation that the application of a localized force against a discrete portion of the mitral valve annulus can terminate mitral regurgitation. This suggests that mitral regurgitation may be localized and nonuniform. Hence, the device applies a force to one or more discrete portions of the atrial wall of the coronary sinus to provide localized mitral valve annulus reshaping instead of generalized reshaping of the mitral valve annulus. Such localized therapy would have all the benefits of the generalized therapy. In addition, a localized therapy device may be easier to implant and adjust.
A still further approach to treat mitral regurgitation from the coronary sinus of the heart contemplates a device having a first anchor configured to be positioned within and fixed to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a cable fixed to the first anchor and extending proximally from the first anchor within the heart, a second anchor configured to be positioned in and fixed in the heart proximal to the first anchor and arranged to slidingly receive the cable, and a lock that locks the cable on the second anchor. When the first and second anchors are fixed within the heart, the cable may be drawn proximally and locked on the second anchor. The geometry of the mitral valve is thereby effected. This approach provides flexibility in that the second anchor may be positioned and fixed in the coronary sinus or alternatively, the second anchor may be positioned and fixed in the right atrium. This approach further allows adjustments in the cable tension after implant.
A still further alternative for treating mitral regurgitation contemplates a device having a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart. A second anchor is configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart. A connecting member, having a fixed length, is permanently attached to the first and second anchors. As a result, when the first and second anchors are within the heart with the first anchor anchored in the coronary sinus, the second anchor may be displaced proximally to effect the geometry of the mitral valve annulus and released to maintain the effect on the mitral valve geometry. The second anchor may be configured, when deployed, to anchor against distal movement but be moveable proximally to permit the second anchor to be displaced proximally within the coronary sinus.
A further approach uses staple devices for effecting mitral valve annulus geometry of a heart. The staples are carried in an elongated catheter placeable in the coronary sinus of the heart adjacent the mitral valve annulus. The staples include first and second leg portions, each leg portion terminating in a tissue piercing end, and a connection portion extending between the first and second leg portions. The connection portions have an initial stressed and distorted configuration to separate the first and second leg portions by a first distance when the tissue piercing ends pierce the mitral valve annulus and a final unstressed and undistorted configuration after the tissue piercing ends pierce the mitral valve annulus to separate the first and second leg portions by a second distance, the second distance being shorter than the first distance. A tool forces the staples from the catheter to cause the tissue piercing ends of the first and second leg portions to pierce the mitral valve annulus with the connection portion of the at least one staple in the initial configuration. The catheter includes a tubular wall having break-away slots adjacent the staples to permit the staples to be forced from the catheter into the adjacent tissue.
The present invention provides a still further approach for effecting mitral valve annulus geometry of a heart.
SUMMARY OF THE INVENTION
The invention provides a device that effects the condition of a mitral valve annulus of a heart. The device includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus, the elongated member having a relatively low resistance to flexure in a first direction and a relatively high resistance to flexure n a second direction. The first and second directions may lie in the same plane.
The elongated member may include a first longitudinal side facing the first direction and a first plurality of notches formed in the first longitudinal side to provide the elongated member with the relatively low resistance to flexure in the first direction. The elongated member may also include a second longitudinal side facing the second direction and a second plurality of notches formed in the second longitudinal side to render the elongated member stable when flexed in the second direction. The first plurality of notches are preferably larger than the second plurality of notches.
The elongated member also has first and second ends and an anchor at each end that fix the device in the coronary sinus. Preferably each anchor anchors the device against longitudinal movement and rotational movement.
The invention further provides a device that effects the condition of a mitral valve annulus of a heart including an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus. The elongated member is flexible when placed in the heart in a first orientation to position the device in the coronary sinus adjacent the mitral valve annulus and relatively inflexible when rotated into a second orientation after the device is positioned in the coronary sinus adjacent to the mitral valve annulus.
The elongated member has a first radius of curvature when in the first orientation and a second radius of curvature when in the second orientation. The first radius of curvature is less than the second radius of curvature.
The invention still further provides a method of effecting the condition of a mitral valve annulus of a heart. The method includes the steps of providing a mitral valve annulus therapy device including an elongated member that is flexible when placed in the heart in a first orientation and relatively inflexible when rotated into a second orientation, advancing the device into the coronary sinus of the heart with the device in the first orientation until the device is adjacent the mitral valve annulus within the coronary sinus, and rotating the device into the second orientation.
The method may further include the step of anchoring the device in the coronary sinus. The device is preferably anchored against at least rotational movement.
The invention still further provides an assembly that effects the condition of a mitral valve annulus of a heart. The assembly includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent to the mitral valve annulus. The elongated member is flexible when placed in the heart in a first orientation to conform to the coronary sinus and relatively inflexible when rotated into a second orientation. The assembly further includes a push member configured to be releasably coupled to the elongated member that advances the elongated member into the coronary sinus adjacent to the mitral valve annulus.
The push member rotates the elongated member into the second orientation upon rotation of the push member. A U-joint releasably couples the elongated member to the push member.
The assembly may further include a flexible catheter having a lumen that receives the elongated member and push member to guide the elongated member into the coronary sinus. The elongated member may be rotated into the second orientation upon rotation of the catheter. The push member may be released from the elongated member with proximal movement of the catheter.
The elongated member has a first radius of curvature when in the first orientation and a second radius of curvature when in the second orientation. The first radius of curvature is less than the second radius of curvature. The elongated member also may have an anchor at each end that fix the device in the coronary sinus. The anchors preferably anchor the device against both longitudinal and rotational movement.
BRIEF DESCRIPTION OF THE DRAWINGS
The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further aspects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like reference numerals identify identical elements, and wherein:
FIG. 1 is a superior view of a human heart with the atria removed;
FIG. 2 is a side plan view of a mitral valve therapy device embodying the present invention;
FIG. 3 is a side plan view to an enlarged scale of a portion of the device of FIG. 2;
FIG. 4 is a partial superior view of a human heart illustrating a first step in the deployment of the mitral valve therapy device embodying the present invention;
FIG. 5 is a view similar to FIG. 4 illustrating a further step in the deployment of the mitral valve therapy device;
FIG. 6 is a superior view of a human heart similar to FIG. 4 illustrating the mitral valve therapy device deployed and anchored in the heart;
FIG. 7 is a partial perspective view of a coupling arrangement between the mitral valve therapy device and a deployment tool in accordance with an embodiment of the present invention; and
FIG. 8 is a partial perspective view illustrating the release of the coupling arrangement of FIG. 7.
DETAILED DESCRIPTION OF THE INVENTION
Referring now to FIG. 1, it is a superior view of a human heart 10 with the atria removed to expose the mitral valve 12, the coronary sinus 14, the coronary artery 15, and the circumflex artery 17 of the heart 10 to lend a better understanding of the present invention. Also generally shown in FIG. 1 are the pulmonary valve 22, the aortic valve 24, and the tricuspid valve 26 of the heart 10.
The mitral valve 12 includes an anterior cusp 16, a posterior cusp 18 and an annulus 20. The annulus encircles the cusps 16 and 18 and maintains their spacing to provide a complete closure during a left ventricular contraction. As is well known, the coronary sinus 14 partially encircles the mitral valve 12 adjacent to the mitral valve annulus 20. As is also known, the coronary sinus is part of the venus system of the heart and extends along the AV groove between the left atrium and the left ventricle. This places the coronary sinus essentially within the same plane as the mitral valve annulus making the coronary sinus available for placement of the mitral valve therapy device of the present invention therein.
FIG. 2 shows a mitral valve therapy device 30 embodying the present invention. The device 30 takes the form of an elongated tubular member 32 which includes a distal anchor 34, a proximal anchor 36, a coupler 38, and a therapy section 40.
The anchors 34 and 36 are shown in FIG. 2 in their predeployed configuration. As will be seen hereinafter, upon deployment of the device 30 in the coronary sinus, the anchors expand outwardly in a toggle bolt manner to anchor the device in the coronary sinus against both longitudinal and rotational movement. To that end, at least the anchors 34 and 36 are formed from a material, such as Nitinol, having shape memory to implement their expansion. The rest of the device 30 may also be formed from Nitinol or other non-rigid biocompatible materials such as stainless steel.
The coupler 38 releasably couples the device to a deployment tool to be described hereinafter during the implant and deployment of the device 30. The coupler forms with the deployment tool a U-joint to permit flexibility. As will also be seen hereinafter, the deployment tool includes a complementary coupler with shape memory for releasing the deployment tool from the elongated member 32.
FIG. 3 shows a portion of the therapy section 40 in greater detail. The elongated member 32, within the therapy section 40, is configured to permit a first flexibility in the elongated member when bent in a first direction and a second and less flexibility in the elongated member 32 when bent in a second direction. More specifically, the elongated member 32 includes a first plurality of slots or notches 42 along a side thereof and a second plurality of slots or notches 44 along an opposite side thereof. The first plurality of notches 42 render the elongated member flexible for bending in the first direction as indicated by arrows 46 and the second plurality of notches 44 render the elongated member flexible for bending in the second direction as indicate by arrows 48. The first plurality of notches 42 are wider or larger than the second plurality of notches 44 so that the elongated member 32 has a relatively low resistance to flexure or bending in the first direction 46 and a relatively high resistance to flexure or bending in the second direction 48.
The relative resistances to flexure allow the device 30 to be readily positioned in the coronary sinus of the heart and then deployed. While in a first orientation, with the first plurality of notches adjacent the mitral valve annulus, the device 30, as it is advanced into the coronary sinus, is permitted to bend and conform to the shape of the coronary sinus. Once properly positioned in the coronary sinus adjacent the mitral valve annulus, the device may be rotated into a second orientation wherein the second plurality of notches 44 are adjacent to the mitral valve annulus. The device 30 may be rotated by either rotating the deployment tool or by rotating a deployment catheter, to be described hereinafter, in which the device resides and which may be used to guide the device 30 into the proper position within the coronary sinus. Once rotated into the second orientation, the elongated member 32 will substantially straighten to act upon and increase the radius of curvature of the adjacent mitral valve annulus.
The second plurality of slots 44 permit slight bending of the elongated member towards the mitral valve annulus to render the device stable in the second orientation. Were the device not permitted to bend slightly towards the mitral valve annulus while in the second orientation, the device could revert to the then more stable first orientation away from the mitral valve annulus. This and further aspects of the present invention will be seen more fully with reference to FIGS. 4-6 which illustrate the deployment of the device 30 in accordance with an embodiment of the present invention.
FIG. 4 illustrates an assembly 28, including the device 30, for effecting the geometry of the mitral valve annulus 20. The assembly is illustrated in an initial stage of deploying the device 30. The assembly includes the device 30, a deployment catheter 50, and the deployment tool or push member 52. The distal end of the push member 52 is coupled to the coupler 38 of the device 30. Both the device 30 and push member 52 are within a lumen 54 of the deployment catheter 50 which is dimensioned to permit the device 30 and push member 52 to be advanced down into the coronary sinus in which the catheter 50 is already positioned.
As the device 30 is advanced into the coronary sinus and adjacent the mitral valve annulus, the device is disposed in the first orientation with the first plurality of notches 42 adjacent the mitral valve annulus 20. This permits the device 30 to bend with relatively low resistance to flexure to conform to the shape of the coronary sinus with a first radius of curvature. As a result, the device 30 may be readily positioned adjacent the mitral valve annulus 20.
With the device 30 positioned in the coronary sinus 14 adjacent the mitral valve annulus 20 as illustrated in FIG. 4, the device may now be rotated into the second orientation as illustrated in FIG. 5. In the second orientation, the second plurality of notches or slots 44 are now adjacent the mitral valve annulus. Because the second plurality of notches are relatively narrow, the higher resistance of flexure of the device in the second orientation will cause the device the substantially straighten to a second and increased radius of curvature. This causes the device to act upon the geometry of the mitral valve annulus 20 by increasing its radius of curvature as illustrated in FIG. 5 to treat and terminate mitral regurgitation, for example.
The device 30 may be rotated by rotating the deployment catheter 50 or by rotating the deployment tool 52 relative to the catheter 50. This permits the assembly 28 to remain intact while the effectiveness of the device placement is evaluated. Should moving the device to a slightly different position be required, this may be accomplished by simply rotating the device back to the first orientation and repositioning the device with the deployment tool 52.
With the device 30 positioned as shown in FIG. 5 and its effectiveness confirmed, the device 30 may now be fully deployed. To that end, the deployment catheter 50 is pulled proximally while the deployment tool or push member 52 is held stationary. This removes the catheter from the device 30.
As illustrated in FIG. 6, the distal anchor 34 is released to expand in a toggle bolt like manner and anchor the device against both longitudinal and rotational movement. The distal anchor 34 is divided into a pair of sections 33 and 35 which are coupled together by a flexible coupling 37. This enables the anchor 34 to better conform to the bend in the coronary sinus at this location of the heart.
Further proximal movement of the deployment catheter 50 releases the proximal anchor 36. It also expands in a toggle bolt like manner to anchor the device against both longitudinal and rotational movement.
When the deployment catheter is moved proximally enough to expose the coupling 38, the coupling 38 is removed from the deployment tool. The deployment tool and the catheter may now be removed from the patient together. Hence, FIG. 6 illustrates the device 30 fully deployed and anchored without the deployment catheter or deployment tool.
FIGS. 6 and 7 show the coupling and decoupling of the device 30 and the deployment tool or push member 52 in greater detail. In FIG. 7 the coupler 38 is shown engaged with a complimentary coupler 58 of the deployment tool 52. The configuration of the couplers 38 and 58 form a U-joint allowing flexibility between the device 30 and the tool 52.
The coupler 58 of the deployment tool 52 has shape memory for disengaging the coupler 38 of the device 30 when the catheter is moved sufficiently proximally to expose the couplers 38 and 58. This is illustrated in FIG. 8. Here it can be seen that the coupler 58 has sufficiently disengaged the coupler 38 of the device 30 to enable the deployment tool 52 to be removed from the patient with the fully deployed and anchored device 30 within the heart to provide its therapeutic effect as illustrated in FIG. 6.
While particular embodiments of the present invention have been shown and described, modifications may be made. It is therefore intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.

Claims (19)

1. A device that effects the condition of a mitral valve annulus of a heart comprising an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus, the elongated member having a relatively low resistance to flexure in a first direction and a relatively high resistance to flexure in a second direction, wherein the first and second directions lie in the same plane, the elongated member has first and second ends and the device includes an anchor at each end that fix the device in the coronary sinus.
2. The device of claim 1 wherein each anchor anchors the device against longitudinal movement and rotational movement.
3. The device of claim 1 wherein the first end anchor comprises an expandable anchor.
4. The device of claim 1 wherein the first end anchor comprises a first anchor section and a second anchor section coupled by a flexible coupling.
5. The device of claim 1 wherein the second end anchor comprises an expandable anchor.
6. An assembly that effects the condition of a mitral valve annulus of a heart comprising:
an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent to the mitral valve annulus, the elongated member being flexible when placed in the heart in a first orientation to conform to the coronary sinus and relatively inflexible when rotated into a second orientation; and
a deployment tool releasably coupled to the elongated member by a releasable coupling assembly.
7. The device of claim 6 wherein the coupling assembly comprises a first coupler associated with the deployment tool and a second coupler associated with the elongated member and complementary with the first coupler.
8. The device of claim 7 wherein the first coupler is adapted to change shape to release from the second coupler.
9. The device of claim 8 wherein the first coupler is formed from shape memory material.
10. The device of claim 7 wherein the first and second couplers form a U-joint.
11. The device of claim 6 wherein the coupling assembly is adapted to be flexible.
12. A method of effecting the condition of a mitral valve annulus of a heart, the method comprising:
providing a mitral valve annulus therapy device having a relatively low resistance to flexure in a first orientation and a relatively high resistance to flexure in a second orientation;
advancing the device with a deployment tool into the coronary sinus of the heart with the device in the first orientation, the deployment tool being connected to the device through a coupling assembly;
rotating the device into the second orientation; and
releasing the device from the deployment tool by actuating the coupling assembly.
13. The method of claim 12 wherein the advancing step comprises permitting the device and deployment tool to flex about the coupling assembly.
14. The method of claim 12 further comprising anchoring a distal end of the device after the rotating step.
15. The method of claim 14 wherein the device comprises a distal anchor, the anchoring step comprising expanding the distal anchor.
16. The method of claim 12 further comprising anchoring a proximal end of the device after the rotating step.
17. The method of claim 14 wherein the device comprises a proximal anchor, the anchoring step comprising expanding the proximal anchor.
18. A method of effecting the condition of a mitral valve annulus of a heart, the method comprising:
providing a mitral valve annulus therapy device having a relatively low resistance to flexure in a first orientation and a relatively high resistance to flexure in a second orientation;
advancing the device with a deployment tool into the coronary sinus of the heart with the device in the first orientation, the deployment tool being connected to the device through a coupling assembly;
rotating the device into the second orientation; and
releasing the device from the deployment tool by actuating the coupling assembly, wherein the coupling assembly comprises a first coupler associated with the deployment tool and a second coupler associated with the elongated member and complementary with the first coupler, the actuating step comprising separating the first coupler from the second coupler.
19. The method of claim 18 wherein the separating step comprises changing a shape of the first coupler.
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Cited By (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040102840A1 (en) * 1999-06-30 2004-05-27 Solem Jan Otto Method and device for treatment of mitral insufficiency
US20050010240A1 (en) * 2003-06-05 2005-01-13 Cardiac Dimensions Inc., A Washington Corporation Device and method for modifying the shape of a body organ
US20090171432A1 (en) * 2005-12-22 2009-07-02 Von Segesser Ludwig K Stent-valves for valve replacement and associated methods and systems for surgery
US7666224B2 (en) 2002-11-12 2010-02-23 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US20100100175A1 (en) * 2001-11-01 2010-04-22 David Reuter Adjustable Height Focal Tissue Deflector
US20100280602A1 (en) * 2003-02-03 2010-11-04 Cardiac Dimensions, Inc. Mitral Valve Device Using Conditioned Shape Memory Alloy
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US20110035000A1 (en) * 2002-01-30 2011-02-10 Cardiac Dimensions, Inc. Tissue Shaping Device
US20110066234A1 (en) * 2002-12-05 2011-03-17 Gordon Lucas S Percutaneous Mitral Valve Annuloplasty Delivery System
US20110166649A1 (en) * 2008-06-16 2011-07-07 Valtech Cardio Ltd. Annuloplasty devices and methods of deliver therefor
DE212010000134U1 (en) 2010-04-28 2012-04-24 Torus Medical Ltd. Device for extending a hose
US8172898B2 (en) 2001-12-05 2012-05-08 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US8250960B2 (en) 2008-08-11 2012-08-28 Cardiac Dimensions, Inc. Catheter cutting tool
US8398672B2 (en) 2003-11-12 2013-03-19 Nitinol Devices And Components, Inc. Method for anchoring a medical device
US20130116780A1 (en) * 2011-11-04 2013-05-09 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US8926695B2 (en) 2006-12-05 2015-01-06 Valtech Cardio, Ltd. Segmented ring placement
US9011531B2 (en) 2012-02-13 2015-04-21 Mitraspan, Inc. Method and apparatus for repairing a mitral valve
US9119719B2 (en) 2009-05-07 2015-09-01 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9414921B2 (en) 2009-10-29 2016-08-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9474606B2 (en) 2009-05-04 2016-10-25 Valtech Cardio, Ltd. Over-wire implant contraction methods
US9526613B2 (en) 2005-03-17 2016-12-27 Valtech Cardio Ltd. Mitral valve treatment techniques
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US9622861B2 (en) 2009-12-02 2017-04-18 Valtech Cardio, Ltd. Tool for actuating an adjusting mechanism
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9661992B2 (en) 2010-04-28 2017-05-30 Torus Medical Ltd. Method and apparatus for extending a tube
US9662209B2 (en) 2008-12-22 2017-05-30 Valtech Cardio, Ltd. Contractible annuloplasty structures
US9713530B2 (en) 2008-12-22 2017-07-25 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US9724192B2 (en) 2011-11-08 2017-08-08 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9883943B2 (en) 2006-12-05 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US9949828B2 (en) 2012-10-23 2018-04-24 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9956077B2 (en) 2003-12-19 2018-05-01 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US9968454B2 (en) 2009-10-29 2018-05-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of artificial chordae
US10076414B2 (en) 2012-02-13 2018-09-18 Mitraspan, Inc. Method and apparatus for repairing a mitral valve
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US10098737B2 (en) 2009-10-29 2018-10-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US10195030B2 (en) 2014-10-14 2019-02-05 Valtech Cardio, Ltd. Leaflet-restraining techniques
US10226342B2 (en) 2016-07-08 2019-03-12 Valtech Cardio, Ltd. Adjustable annuloplasty device with alternating peaks and troughs
US10231831B2 (en) 2009-12-08 2019-03-19 Cardiovalve Ltd. Folding ring implant for heart valve
WO2019051587A1 (en) * 2017-09-12 2019-03-21 Cheema Asim Apparatus and system for changing mitral valve annulus geometry
US10299793B2 (en) 2013-10-23 2019-05-28 Valtech Cardio, Ltd. Anchor magazine
US10350068B2 (en) 2009-02-17 2019-07-16 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
US10390953B2 (en) 2017-03-08 2019-08-27 Cardiac Dimensions Pty. Ltd. Methods and devices for reducing paravalvular leakage
US10449333B2 (en) 2013-03-14 2019-10-22 Valtech Cardio, Ltd. Guidewire feeder
US10456258B2 (en) 2002-05-08 2019-10-29 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US10470882B2 (en) 2008-12-22 2019-11-12 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US10682232B2 (en) 2013-03-15 2020-06-16 Edwards Lifesciences Corporation Translation catheters, systems, and methods of use thereof
US10695046B2 (en) 2005-07-05 2020-06-30 Edwards Lifesciences Corporation Tissue anchor and anchoring system
US10702274B2 (en) 2016-05-26 2020-07-07 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US10751182B2 (en) 2015-12-30 2020-08-25 Edwards Lifesciences Corporation System and method for reshaping right heart
US10765514B2 (en) 2015-04-30 2020-09-08 Valtech Cardio, Ltd. Annuloplasty technologies
US10792152B2 (en) 2011-06-23 2020-10-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US10828160B2 (en) 2015-12-30 2020-11-10 Edwards Lifesciences Corporation System and method for reducing tricuspid regurgitation
US10835221B2 (en) 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US10918373B2 (en) 2013-08-31 2021-02-16 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US10918374B2 (en) 2013-02-26 2021-02-16 Edwards Lifesciences Corporation Devices and methods for percutaneous tricuspid valve repair
US10925610B2 (en) 2015-03-05 2021-02-23 Edwards Lifesciences Corporation Devices for treating paravalvular leakage and methods use thereof
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11026791B2 (en) 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11033257B2 (en) 2005-01-20 2021-06-15 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US11045627B2 (en) 2017-04-18 2021-06-29 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11123191B2 (en) 2018-07-12 2021-09-21 Valtech Cardio Ltd. Annuloplasty systems and locking tools therefor
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
US11285003B2 (en) 2018-03-20 2022-03-29 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof
US11285005B2 (en) 2006-07-17 2022-03-29 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US11311380B2 (en) 2003-05-02 2022-04-26 Cardiac Dimensions Pty. Ltd. Device and method for modifying the shape of a body organ
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US11395648B2 (en) 2012-09-29 2022-07-26 Edwards Lifesciences Corporation Plication lock delivery system and method of use thereof
US11490896B2 (en) * 2013-03-15 2022-11-08 Covidien Lp Delivery and detachment mechanisms for vascular implants
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US11596771B2 (en) 2020-12-14 2023-03-07 Cardiac Dimensions Pty. Ltd. Modular pre-loaded medical implants and delivery systems
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US11660191B2 (en) 2008-03-10 2023-05-30 Edwards Lifesciences Corporation Method to reduce mitral regurgitation
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US11666442B2 (en) 2018-01-26 2023-06-06 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
US11779463B2 (en) 2018-01-24 2023-10-10 Edwards Lifesciences Innovation (Israel) Ltd. Contraction of an annuloplasty structure
US11779458B2 (en) 2016-08-10 2023-10-10 Cardiovalve Ltd. Prosthetic valve with leaflet connectors
US11801135B2 (en) 2015-02-05 2023-10-31 Cardiovalve Ltd. Techniques for deployment of a prosthetic valve
US11819411B2 (en) 2019-10-29 2023-11-21 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty and tissue anchor technologies
US11844691B2 (en) 2013-01-24 2023-12-19 Cardiovalve Ltd. Partially-covered prosthetic valves
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
US11931261B2 (en) 2022-02-17 2024-03-19 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof

Families Citing this family (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6050936A (en) 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
WO1999000059A1 (en) * 1997-06-27 1999-01-07 The Trustees Of Columbia University In The City Of New York Method and apparatus for circulatory valve repair
FR2768324B1 (en) 1997-09-12 1999-12-10 Jacques Seguin SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER
US6332893B1 (en) 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
AU770243B2 (en) 1999-04-09 2004-02-19 Evalve, Inc. Methods and apparatus for cardiac valve repair
US10327743B2 (en) 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
SE514718C2 (en) * 1999-06-29 2001-04-09 Jan Otto Solem Apparatus for treating defective closure of the mitral valve apparatus
US6997951B2 (en) * 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
EP1113497A3 (en) * 1999-12-29 2006-01-25 Texas Instruments Incorporated Semiconductor package with conductor impedance selected during assembly
US6989028B2 (en) * 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US7591826B2 (en) * 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
US20060069429A1 (en) * 2001-04-24 2006-03-30 Spence Paul A Tissue fastening systems and methods utilizing magnetic guidance
US7037334B1 (en) 2001-04-24 2006-05-02 Mitralign, Inc. Method and apparatus for catheter-based annuloplasty using local plications
US8202315B2 (en) 2001-04-24 2012-06-19 Mitralign, Inc. Catheter-based annuloplasty using ventricularly positioned catheter
US6676702B2 (en) * 2001-05-14 2004-01-13 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method
US6800090B2 (en) * 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6949122B2 (en) * 2001-11-01 2005-09-27 Cardiac Dimensions, Inc. Focused compression mitral valve device and method
US7311729B2 (en) * 2002-01-30 2007-12-25 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6575971B2 (en) 2001-11-15 2003-06-10 Quantum Cor, Inc. Cardiac valve leaflet stapler device and methods thereof
US6793673B2 (en) * 2002-12-26 2004-09-21 Cardiac Dimensions, Inc. System and method to effect mitral valve annulus of a heart
US6908478B2 (en) * 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
AU2002360066B2 (en) * 2001-12-28 2008-11-06 Edwards Lifesciences Ag Delayed memory device
SE524709C2 (en) * 2002-01-11 2004-09-21 Edwards Lifesciences Ag Device for delayed reshaping of a heart vessel and a heart valve
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US20050209690A1 (en) * 2002-01-30 2005-09-22 Mathis Mark L Body lumen shaping device with cardiac leads
US6960229B2 (en) * 2002-01-30 2005-11-01 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US7125420B2 (en) * 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US7004958B2 (en) * 2002-03-06 2006-02-28 Cardiac Dimensions, Inc. Transvenous staples, assembly and method for mitral valve repair
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
ES2370585T3 (en) * 2002-03-27 2011-12-20 Sorin Biomedica Cardio S.R.L. PROSTHESIS FOR ANULOPLASTY THAT INCLUDES A PERFORATED ELEMENT.
US7007698B2 (en) 2002-04-03 2006-03-07 Boston Scientific Corporation Body lumen closure
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
EP2039325A1 (en) 2002-05-08 2009-03-25 Cardiac Dimensions, Inc. Device for modifying the shape of a body organ
BR0315392A (en) 2002-10-21 2005-08-23 Mitralign Inc Incrementing catheters and methods of performing annuloplasty
US8979923B2 (en) 2002-10-21 2015-03-17 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
WO2004037128A1 (en) 2002-10-24 2004-05-06 Boston Scientific Limited Venous valve apparatus and method
US7247134B2 (en) * 2002-11-12 2007-07-24 Myocor, Inc. Devices and methods for heart valve treatment
US7316708B2 (en) * 2002-12-05 2008-01-08 Cardiac Dimensions, Inc. Medical device delivery system
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
US20040158321A1 (en) * 2003-02-12 2004-08-12 Cardiac Dimensions, Inc. Method of implanting a mitral valve therapy device
US20040254600A1 (en) * 2003-02-26 2004-12-16 David Zarbatany Methods and devices for endovascular mitral valve correction from the left coronary sinus
EP1608297A2 (en) * 2003-03-18 2005-12-28 St. Jude Medical, Inc. Body tissue remodeling apparatus
WO2004093745A1 (en) * 2003-04-23 2004-11-04 Cook Incorporated Devices kits, and methods for placing multiple intraluminal medical devices in a body vessel
US20060161169A1 (en) * 2003-05-02 2006-07-20 Cardiac Dimensions, Inc., A Delaware Corporation Device and method for modifying the shape of a body organ
US20040220657A1 (en) * 2003-05-02 2004-11-04 Cardiac Dimensions, Inc., A Washington Corporation Tissue shaping device with conformable anchors
US10667823B2 (en) 2003-05-19 2020-06-02 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US7235093B2 (en) * 2003-05-20 2007-06-26 Boston Scientific Scimed, Inc. Mechanism to improve stent securement
US20060136053A1 (en) * 2003-05-27 2006-06-22 Rourke Jonathan M Method and apparatus for improving mitral valve function
EP1628599A4 (en) * 2003-05-27 2011-12-28 Viacor Inc Method and apparatus for improving mitral valve function
US7351259B2 (en) * 2003-06-05 2008-04-01 Cardiac Dimensions, Inc. Device, system and method to affect the mitral valve annulus of a heart
EP1646332B1 (en) * 2003-07-18 2015-06-17 Edwards Lifesciences AG Remotely activated mitral annuloplasty system
AU2004258950B2 (en) * 2003-07-23 2010-11-04 Viacor, Inc. Method and apparatus for improving mitral valve function
US7004176B2 (en) * 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US20060184242A1 (en) * 2003-10-20 2006-08-17 Samuel Lichtenstein Method and apparatus for percutaneous reduction of anterior-posterior diameter of mitral valve
US20050177228A1 (en) * 2003-12-16 2005-08-11 Solem Jan O. Device for changing the shape of the mitral annulus
AU2004298762A1 (en) * 2003-12-16 2005-06-30 Edwards Lifesciences Ag Device for changing the shape of the mitral annulus
US20050137449A1 (en) * 2003-12-19 2005-06-23 Cardiac Dimensions, Inc. Tissue shaping device with self-expanding anchors
US20050137450A1 (en) * 2003-12-19 2005-06-23 Cardiac Dimensions, Inc., A Washington Corporation Tapered connector for tissue shaping device
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US7794496B2 (en) 2003-12-19 2010-09-14 Cardiac Dimensions, Inc. Tissue shaping device with integral connector and crimp
US7837728B2 (en) 2003-12-19 2010-11-23 Cardiac Dimensions, Inc. Reduced length tissue shaping device
US7431726B2 (en) 2003-12-23 2008-10-07 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
US8864822B2 (en) 2003-12-23 2014-10-21 Mitralign, Inc. Devices and methods for introducing elements into tissue
WO2005087139A1 (en) 2004-03-15 2005-09-22 Baker Medical Research Institute Treating valve failure
US7993397B2 (en) 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
EP1750592B1 (en) 2004-05-14 2016-12-28 Evalve, Inc. Locking mechanisms for fixation devices
US7775968B2 (en) 2004-06-14 2010-08-17 Pneumrx, Inc. Guided access to lung tissues
US20050288702A1 (en) * 2004-06-16 2005-12-29 Mcgurk Erin Intra-bronchial lung volume reduction system
EP1781179A1 (en) * 2004-07-06 2007-05-09 Baker Medical Research Institute Treating valvular insufficiency
WO2006014567A2 (en) 2004-07-08 2006-02-09 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US7635329B2 (en) 2004-09-27 2009-12-22 Evalve, Inc. Methods and devices for tissue grasping and assessment
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
EP1816945B1 (en) 2004-11-23 2019-08-21 PneumRx, Inc. Steerable device for accessing a target site
US7211110B2 (en) 2004-12-09 2007-05-01 Edwards Lifesciences Corporation Diagnostic kit to assist with heart valve annulus adjustment
SE0403046D0 (en) * 2004-12-15 2004-12-15 Medtentia Ab A device and method for improving the function of a heart valve
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US7878966B2 (en) 2005-02-04 2011-02-01 Boston Scientific Scimed, Inc. Ventricular assist and support device
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8470028B2 (en) 2005-02-07 2013-06-25 Evalve, Inc. Methods, systems and devices for cardiac valve repair
EP3967269A3 (en) 2005-02-07 2022-07-13 Evalve, Inc. Systems and devices for cardiac valve repair
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7357815B2 (en) * 2005-04-21 2008-04-15 Micardia Corporation Dynamically adjustable implants and methods for reshaping tissue
US7500989B2 (en) * 2005-06-03 2009-03-10 Edwards Lifesciences Corp. Devices and methods for percutaneous repair of the mitral valve via the coronary sinus
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US20070038297A1 (en) * 2005-08-12 2007-02-15 Bobo Donald E Jr Medical implant with reinforcement mechanism
US20080221673A1 (en) * 2005-08-12 2008-09-11 Donald Bobo Medical implant with reinforcement mechanism
US9492277B2 (en) 2005-08-30 2016-11-15 Mayo Foundation For Medical Education And Research Soft body tissue remodeling methods and apparatus
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US20070073391A1 (en) * 2005-09-28 2007-03-29 Henry Bourang System and method for delivering a mitral valve repair device
US20070173926A1 (en) * 2005-12-09 2007-07-26 Bobo Donald E Jr Anchoring system for medical implant
WO2007070797A2 (en) 2005-12-13 2007-06-21 Cordis Development Corporation Detachment actuator for use with medical device deployment systems
EP1803420B1 (en) * 2005-12-28 2009-07-01 Sorin Biomedica Cardio S.R.L. Annuloplasty prosthesis with an auxetic structure
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US7942894B2 (en) * 2006-01-31 2011-05-17 Codman & Shurtleff, Inc. Embolic device delivery system
US7637946B2 (en) 2006-02-09 2009-12-29 Edwards Lifesciences Corporation Coiled implant for mitral valve repair
US7749249B2 (en) 2006-02-21 2010-07-06 Kardium Inc. Method and device for closing holes in tissue
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8721734B2 (en) 2009-05-18 2014-05-13 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US7503932B2 (en) * 2006-04-11 2009-03-17 Cardiac Dimensions, Inc. Mitral valve annuloplasty device with vena cava anchor
US9101338B2 (en) * 2006-05-03 2015-08-11 Mayo Foundation For Medical Education And Research Soft body tissue remodeling methods and apparatus
US20070270688A1 (en) 2006-05-19 2007-11-22 Daniel Gelbart Automatic atherectomy system
US8920411B2 (en) 2006-06-28 2014-12-30 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
US11389232B2 (en) 2006-06-28 2022-07-19 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US10028783B2 (en) 2006-06-28 2018-07-24 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US9119633B2 (en) 2006-06-28 2015-09-01 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US8366720B2 (en) 2006-07-31 2013-02-05 Codman & Shurtleff, Inc. Interventional medical device system having an elongation retarding portion and method of using the same
US8062325B2 (en) 2006-07-31 2011-11-22 Codman & Shurtleff, Inc. Implantable medical device detachment system and methods of using the same
US7837610B2 (en) 2006-08-02 2010-11-23 Kardium Inc. System for improving diastolic dysfunction
US20080065205A1 (en) * 2006-09-11 2008-03-13 Duy Nguyen Retrievable implant and method for treatment of mitral regurgitation
US7879087B2 (en) * 2006-10-06 2011-02-01 Edwards Lifesciences Corporation Mitral and tricuspid annuloplasty rings
US7854849B2 (en) * 2006-10-10 2010-12-21 Multiphase Systems Integration Compact multiphase inline bulk water separation method and system for hydrocarbon production
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
JP5313928B2 (en) 2007-02-05 2013-10-09 ボストン サイエンティフィック リミテッド Percutaneous valves and systems
US8911461B2 (en) 2007-03-13 2014-12-16 Mitralign, Inc. Suture cutter and method of cutting suture
US8845723B2 (en) 2007-03-13 2014-09-30 Mitralign, Inc. Systems and methods for introducing elements into tissue
US20080255447A1 (en) * 2007-04-16 2008-10-16 Henry Bourang Diagnostic catheter
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US8100820B2 (en) 2007-08-22 2012-01-24 Edwards Lifesciences Corporation Implantable device for treatment of ventricular dilation
US8906011B2 (en) 2007-11-16 2014-12-09 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8489172B2 (en) 2008-01-25 2013-07-16 Kardium Inc. Liposuction system
US20090287304A1 (en) 2008-05-13 2009-11-19 Kardium Inc. Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
EP2633821B1 (en) 2009-09-15 2016-04-06 Evalve, Inc. Device for cardiac valve repair
WO2011041571A2 (en) 2009-10-01 2011-04-07 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US8961596B2 (en) 2010-01-22 2015-02-24 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
ES2365317B1 (en) 2010-03-19 2012-08-03 Xavier Ruyra Baliarda PROTESTIC BAND, IN PARTICULAR FOR THE REPAIR OF A MITRAL VALVE.
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9539670B2 (en) * 2010-05-25 2017-01-10 Creganna-Tactx Medical Joint for tubular materials
US9050066B2 (en) 2010-06-07 2015-06-09 Kardium Inc. Closing openings in anatomical tissue
US8940002B2 (en) 2010-09-30 2015-01-27 Kardium Inc. Tissue anchor system
US9486273B2 (en) 2011-01-21 2016-11-08 Kardium Inc. High-density electrode-based medical device system
US9452016B2 (en) 2011-01-21 2016-09-27 Kardium Inc. Catheter system
US11259867B2 (en) 2011-01-21 2022-03-01 Kardium Inc. High-density electrode-based medical device system
CA2764494A1 (en) 2011-01-21 2012-07-21 Kardium Inc. Enhanced medical device for use in bodily cavities, for example an atrium
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
EP2734157B1 (en) 2011-07-21 2018-09-05 4Tech Inc. Apparatus for tricuspid valve repair using tension
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
USD777925S1 (en) 2012-01-20 2017-01-31 Kardium Inc. Intra-cardiac procedure device
USD777926S1 (en) 2012-01-20 2017-01-31 Kardium Inc. Intra-cardiac procedure device
US9011423B2 (en) 2012-05-21 2015-04-21 Kardium, Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US9198592B2 (en) 2012-05-21 2015-12-01 Kardium Inc. Systems and methods for activating transducers
US10827977B2 (en) 2012-05-21 2020-11-10 Kardium Inc. Systems and methods for activating transducers
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US8961594B2 (en) 2012-05-31 2015-02-24 4Tech Inc. Heart valve repair system
US9788948B2 (en) 2013-01-09 2017-10-17 4 Tech Inc. Soft tissue anchors and implantation techniques
CN105208978B (en) 2013-03-14 2016-12-07 4科技有限公司 There is the support of tether interface
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
EP3323389B1 (en) 2013-08-14 2020-05-06 Sorin Group Italia S.r.l. Apparatus for chordal replacement
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
WO2015063580A2 (en) 2013-10-30 2015-05-07 4Tech Inc. Multiple anchoring-point tension system
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
US10368936B2 (en) 2014-11-17 2019-08-06 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US10722184B2 (en) 2014-11-17 2020-07-28 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
JP6717820B2 (en) 2014-12-02 2020-07-08 4テック インコーポレイテッド Eccentric tissue anchor
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
US10524912B2 (en) 2015-04-02 2020-01-07 Abbott Cardiovascular Systems, Inc. Tissue fixation devices and methods
US10376673B2 (en) 2015-06-19 2019-08-13 Evalve, Inc. Catheter guiding system and methods
US10238494B2 (en) 2015-06-29 2019-03-26 Evalve, Inc. Self-aligning radiopaque ring
US10667815B2 (en) 2015-07-21 2020-06-02 Evalve, Inc. Tissue grasping devices and related methods
US10413408B2 (en) 2015-08-06 2019-09-17 Evalve, Inc. Delivery catheter systems, methods, and devices
US10238495B2 (en) 2015-10-09 2019-03-26 Evalve, Inc. Delivery catheter handle and methods of use
US10278818B2 (en) * 2015-12-10 2019-05-07 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve annulus
CN108882981B (en) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 Prosthetic valve for preventing outflow obstruction
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US10779837B2 (en) 2016-12-08 2020-09-22 Evalve, Inc. Adjustable arm device for grasping tissues
US10314586B2 (en) 2016-12-13 2019-06-11 Evalve, Inc. Rotatable device and method for fixing tricuspid valve tissue
WO2018112429A1 (en) 2016-12-16 2018-06-21 Edwards Lifesciences Corporation Deployment systems, tools, and methods for delivering an anchoring device for a prosthetic valve
US11065119B2 (en) 2017-05-12 2021-07-20 Evalve, Inc. Long arm valve repair clip
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
WO2019079788A1 (en) 2017-10-20 2019-04-25 Boston Scientific Scimed, Inc. Heart valve repair implant for treating tricuspid regurgitation
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
CA3135753C (en) 2019-04-01 2023-10-24 Neovasc Tiara Inc. Controllably deployable prosthetic valve
CA3136334A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
WO2020236931A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
CN114144144A (en) 2019-06-20 2022-03-04 内奥瓦斯克迪亚拉公司 Low-profile prosthetic mitral valve
US11857417B2 (en) 2020-08-16 2024-01-02 Trilio Medical Ltd. Leaflet support

Citations (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995623A (en) 1974-12-23 1976-12-07 American Hospital Supply Corporation Multipurpose flow-directed catheter
US4055861A (en) 1975-04-11 1977-11-01 Rhone-Poulenc Industries Support for a natural human heart valve
US4164046A (en) 1977-05-16 1979-08-14 Cooley Denton Valve prosthesis
US4485816A (en) 1981-06-25 1984-12-04 Alchemia Shape-memory surgical staple apparatus and method for use in surgical suturing
US4550870A (en) 1983-10-13 1985-11-05 Alchemia Ltd. Partnership Stapling device
US4588395A (en) 1978-03-10 1986-05-13 Lemelson Jerome H Catheter and method
US4830023A (en) 1987-11-27 1989-05-16 Medi-Tech, Incorporated Medical guidewire
US5061277A (en) 1986-08-06 1991-10-29 Baxter International Inc. Flexible cardiac valvular support prosthesis
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US5261916A (en) 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5265601A (en) 1992-05-01 1993-11-30 Medtronic, Inc. Dual chamber cardiac pacing from a single electrode
US5350420A (en) 1989-07-31 1994-09-27 Baxter International Inc. Flexible annuloplasty ring and holder
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US5474557A (en) 1993-09-21 1995-12-12 Mai; Christian Multibranch osteosynthesis clip with dynamic compression and self-retention
US5514161A (en) 1994-04-05 1996-05-07 Ela Medical S.A. Methods and apparatus for controlling atrial stimulation in a double atrial triple chamber cardiac pacemaker
US5554177A (en) 1995-03-27 1996-09-10 Medtronic, Inc. Method and apparatus to optimize pacing based on intensity of acoustic signal
US5562698A (en) 1994-03-09 1996-10-08 Cook Incorporated Intravascular treatment system
US5584867A (en) 1994-04-05 1996-12-17 Ela Medical S.A. Method and apparatus for controlling a double atrial triple chamber cardiac pacemaker having a fallback mode
US5601600A (en) 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US5676671A (en) 1995-04-12 1997-10-14 Inoue; Kanji Device for introducing an appliance to be implanted into a catheter
US5733325A (en) 1993-11-04 1998-03-31 C. R. Bard, Inc. Non-migrating vascular prosthesis and minimally invasive placement system
US5824071A (en) 1996-09-16 1998-10-20 Circulation, Inc. Apparatus for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5895391A (en) 1996-09-27 1999-04-20 Target Therapeutics, Inc. Ball lock joint and introducer for vaso-occlusive member
US5899882A (en) 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
US5908404A (en) 1996-05-13 1999-06-01 Elliott; James B. Methods for inserting an implant
US5928258A (en) 1997-09-26 1999-07-27 Corvita Corporation Method and apparatus for loading a stent or stent-graft into a delivery sheath
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US5961545A (en) 1997-01-17 1999-10-05 Meadox Medicals, Inc. EPTFE graft-stent composite device
US5978705A (en) 1997-03-14 1999-11-02 Uab Research Foundation Method and apparatus for treating cardiac arrhythmia using auxiliary pulse
US5984944A (en) 1997-09-12 1999-11-16 B. Braun Medical, Inc. Introducer for an expandable vascular occlusion device
US6015402A (en) 1997-03-07 2000-01-18 Sahota; Harvinder Wire perfusion catheter
US6027517A (en) 1994-02-24 2000-02-22 Radiance Medical Systems, Inc. Fixed focal balloon for interactive angioplasty and stent implantation catheter with focalized balloon
US6077295A (en) 1996-07-15 2000-06-20 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system
US6096064A (en) 1997-09-19 2000-08-01 Intermedics Inc. Four chamber pacer for dilated cardiomyopthy
US6099549A (en) 1998-07-03 2000-08-08 Cordis Corporation Vascular filter for controlled release
US6099552A (en) 1997-11-12 2000-08-08 Boston Scientific Corporation Gastrointestinal copression clips
US6129755A (en) 1998-01-09 2000-10-10 Nitinol Development Corporation Intravascular stent having an improved strut configuration
US6171320B1 (en) 1996-12-25 2001-01-09 Niti Alloys Technologies Ltd. Surgical clip
US6183512B1 (en) 1999-04-16 2001-02-06 Edwards Lifesciences Corporation Flexible annuloplasty system
US6190406B1 (en) 1998-01-09 2001-02-20 Nitinal Development Corporation Intravascular stent having tapered struts
US6210432B1 (en) 1999-06-29 2001-04-03 Jan Otto Solem Device and method for treatment of mitral insufficiency
US6254628B1 (en) 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US6267783B1 (en) 1998-11-09 2001-07-31 Cordis Corporation Stent which is easily recaptured and repositioned within the body
US6275730B1 (en) 1997-03-14 2001-08-14 Uab Research Foundation Method and apparatus for treating cardiac arrythmia
US20010018611A1 (en) 1999-06-30 2001-08-30 Solem Jan Otto Method and device for treatment of mitral insufficiency
US20010044568A1 (en) 2000-01-31 2001-11-22 Langberg Jonathan J. Endoluminal ventricular retention
US20010049558A1 (en) 2000-01-14 2001-12-06 Liddicoat John R. Tissue annuloplasty band and apparatus and method for fashioning, sizing and implanting the same
US6342067B1 (en) 1998-01-09 2002-01-29 Nitinol Development Corporation Intravascular stent having curved bridges for connecting adjacent hoops
US6345198B1 (en) 1998-01-23 2002-02-05 Pacesetter, Inc. Implantable stimulation system for providing dual bipolar sensing using an electrode positioned in proximity to the tricuspid valve and programmable polarity
US6352561B1 (en) 1996-12-23 2002-03-05 W. L. Gore & Associates Implant deployment apparatus
US6352553B1 (en) 1995-12-14 2002-03-05 Gore Enterprise Holdings, Inc. Stent-graft deployment apparatus and method
US6358195B1 (en) 2000-03-09 2002-03-19 Neoseed Technology Llc Method and apparatus for loading radioactive seeds into brachytherapy needles
US20020035361A1 (en) 1999-06-25 2002-03-21 Houser Russell A. Apparatus and methods for treating tissue
US20020042651A1 (en) 2000-06-30 2002-04-11 Liddicoat John R. Method and apparatus for performing a procedure on a cardiac valve
US20020042621A1 (en) 2000-06-23 2002-04-11 Liddicoat John R. Automated annular plication for mitral valve repair
US20020049468A1 (en) 2000-06-30 2002-04-25 Streeter Richard B. Intravascular filter with debris entrapment mechanism
US20020055774A1 (en) 2000-09-07 2002-05-09 Liddicoat John R. Fixation band for affixing a prosthetic heart valve to tissue
US6395017B1 (en) 1996-11-15 2002-05-28 C. R. Bard, Inc. Endoprosthesis delivery catheter with sequential stage control
US20020065554A1 (en) 2000-10-25 2002-05-30 Streeter Richard B. Mitral shield
US20020087173A1 (en) 2000-12-28 2002-07-04 Alferness Clifton A. Mitral valve constricting device, system and method
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US20020095167A1 (en) 2000-10-23 2002-07-18 Liddicoat John R. Automated annular plication for mitral valve repair
US20020103532A1 (en) 2001-01-30 2002-08-01 Langberg Jonathan J. Transluminal mitral annuloplasty
US6442427B1 (en) 2000-04-27 2002-08-27 Medtronic, Inc. Method and system for stimulating a mammalian heart
US20020138044A1 (en) 2000-10-27 2002-09-26 Streeter Richard B. Intracardiovascular access (ICVATM) system
US20020151961A1 (en) 2000-01-31 2002-10-17 Lashinski Randall T. Medical system and method for remodeling an extravascular tissue structure
US20020161377A1 (en) 2001-04-27 2002-10-31 Dmitry Rabkin Apparatus for delivering, repositioning and/or retrieving self-expanding stents
US6503271B2 (en) 1998-01-09 2003-01-07 Cordis Corporation Intravascular device with improved radiopacity
US6569198B1 (en) 2000-03-31 2003-05-27 Richard A. Wilson Mitral or tricuspid valve annuloplasty prosthetic device
US6589208B2 (en) 2000-06-20 2003-07-08 Applied Medical Resources Corporation Self-deploying catheter assembly
US6602289B1 (en) 1999-06-08 2003-08-05 S&A Rings, Llc Annuloplasty rings of particular use in surgery for the mitral valve
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US6629534B1 (en) 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US6629994B2 (en) 2001-06-11 2003-10-07 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6643546B2 (en) 2001-02-13 2003-11-04 Quetzal Biomedical, Inc. Multi-electrode apparatus and method for treatment of congestive heart failure
US6709425B2 (en) 1998-09-30 2004-03-23 C. R. Bard, Inc. Vascular inducing implants
US6716158B2 (en) 2001-09-07 2004-04-06 Mardil, Inc. Method and apparatus for external stabilization of the heart
US6718985B2 (en) 2001-04-24 2004-04-13 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty using local plications
US6721598B1 (en) 2001-08-31 2004-04-13 Pacesetter, Inc. Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6733521B2 (en) 2001-04-11 2004-05-11 Trivascular, Inc. Delivery system and method for endovascular graft
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US6793673B2 (en) 2002-12-26 2004-09-21 Cardiac Dimensions, Inc. System and method to effect mitral valve annulus of a heart
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
US6800090B2 (en) 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
US6960229B2 (en) 2002-01-30 2005-11-01 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6966926B2 (en) 2001-05-14 2005-11-22 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU764886B2 (en) 1999-01-27 2003-09-04 Viacor Incorporated Cardiac valve procedure methods and devices
US6758830B1 (en) * 1999-05-11 2004-07-06 Atrionix, Inc. Catheter positioning system
US6997951B2 (en) * 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
IL136213A0 (en) 2000-05-17 2001-05-20 Xtent Medical Inc Selectively expandable and releasable stent
AU2002236640A1 (en) 2000-12-15 2002-06-24 Viacor, Inc. Apparatus and method for replacing aortic valve
EP1355590B1 (en) * 2001-01-30 2008-12-10 Edwards Lifesciences AG Medical system for remodeling an extravascular tissue structure
US6829017B2 (en) * 2001-02-01 2004-12-07 Avid Technology, Inc. Specifying a point of origin of a sound for audio effects using displayed visual information from a motion picture
CA2437824C (en) 2001-02-05 2008-09-23 Viacor, Inc. Apparatus and method for reducing mitral regurgitation
AU2002240288B2 (en) 2001-02-05 2006-05-18 Viacor, Inc. Method and apparatus for improving mitral valve function
AU2002327224A1 (en) * 2001-03-05 2002-12-09 Viacor, Incorporated Apparatus and method for reducing mitral regurgitation
CA2441886C (en) 2001-03-23 2009-07-21 Viacor, Incorporated Method and apparatus for reducing mitral regurgitation
ATE397426T1 (en) 2001-03-29 2008-06-15 Viacor Inc DEVICE FOR IMPROVING MITRAL VALVE FUNCTION
US7186264B2 (en) * 2001-03-29 2007-03-06 Viacor, Inc. Method and apparatus for improving mitral valve function
US20030078654A1 (en) 2001-08-14 2003-04-24 Taylor Daniel C. Method and apparatus for improving mitral valve function
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
AUPR847301A0 (en) * 2001-10-26 2001-11-15 Cook Incorporated Endoluminal prostheses for curved lumens
US7052487B2 (en) * 2001-10-26 2006-05-30 Cohn William E Method and apparatus for reducing mitral regurgitation
US6949122B2 (en) * 2001-11-01 2005-09-27 Cardiac Dimensions, Inc. Focused compression mitral valve device and method
US7635387B2 (en) * 2001-11-01 2009-12-22 Cardiac Dimensions, Inc. Adjustable height focal tissue deflector
US6824562B2 (en) * 2002-05-08 2004-11-30 Cardiac Dimensions, Inc. Body lumen device anchor, device and assembly
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US7179282B2 (en) * 2001-12-05 2007-02-20 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
DE10161543B4 (en) 2001-12-11 2004-02-19 REITAN, Öyvind Implant for the treatment of heart valve insufficiency
SE524709C2 (en) 2002-01-11 2004-09-21 Edwards Lifesciences Ag Device for delayed reshaping of a heart vessel and a heart valve
US7125420B2 (en) * 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US7004958B2 (en) 2002-03-06 2006-02-28 Cardiac Dimensions, Inc. Transvenous staples, assembly and method for mitral valve repair
EP2039325A1 (en) * 2002-05-08 2009-03-25 Cardiac Dimensions, Inc. Device for modifying the shape of a body organ
KR101050626B1 (en) * 2002-08-29 2011-07-19 미트랄 솔루션스, 인크. Implantation device for controlling the inner circumference of the anatomical orifice or lumen
US7247134B2 (en) * 2002-11-12 2007-07-24 Myocor, Inc. Devices and methods for heart valve treatment
US7112219B2 (en) * 2002-11-12 2006-09-26 Myocor, Inc. Devices and methods for heart valve treatment
US7316708B2 (en) * 2002-12-05 2008-01-08 Cardiac Dimensions, Inc. Medical device delivery system
US7837729B2 (en) * 2002-12-05 2010-11-23 Cardiac Dimensions, Inc. Percutaneous mitral valve annuloplasty delivery system
US20040133240A1 (en) * 2003-01-07 2004-07-08 Cardiac Dimensions, Inc. Electrotherapy system, device, and method for treatment of cardiac valve dysfunction
US7314485B2 (en) * 2003-02-03 2008-01-01 Cardiac Dimensions, Inc. Mitral valve device using conditioned shape memory alloy
US20060161169A1 (en) * 2003-05-02 2006-07-20 Cardiac Dimensions, Inc., A Delaware Corporation Device and method for modifying the shape of a body organ
US7351259B2 (en) * 2003-06-05 2008-04-01 Cardiac Dimensions, Inc. Device, system and method to affect the mitral valve annulus of a heart
US7887582B2 (en) * 2003-06-05 2011-02-15 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US20050137450A1 (en) * 2003-12-19 2005-06-23 Cardiac Dimensions, Inc., A Washington Corporation Tapered connector for tissue shaping device
US20050137449A1 (en) * 2003-12-19 2005-06-23 Cardiac Dimensions, Inc. Tissue shaping device with self-expanding anchors
US7837728B2 (en) * 2003-12-19 2010-11-23 Cardiac Dimensions, Inc. Reduced length tissue shaping device
US7794496B2 (en) * 2003-12-19 2010-09-14 Cardiac Dimensions, Inc. Tissue shaping device with integral connector and crimp
JP4926980B2 (en) * 2005-01-20 2012-05-09 カーディアック ディメンションズ インコーポレイテッド Tissue shaping device

Patent Citations (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995623A (en) 1974-12-23 1976-12-07 American Hospital Supply Corporation Multipurpose flow-directed catheter
US4055861A (en) 1975-04-11 1977-11-01 Rhone-Poulenc Industries Support for a natural human heart valve
US4164046A (en) 1977-05-16 1979-08-14 Cooley Denton Valve prosthesis
US4588395A (en) 1978-03-10 1986-05-13 Lemelson Jerome H Catheter and method
US4485816A (en) 1981-06-25 1984-12-04 Alchemia Shape-memory surgical staple apparatus and method for use in surgical suturing
US4550870A (en) 1983-10-13 1985-11-05 Alchemia Ltd. Partnership Stapling device
US5061277B1 (en) 1986-08-06 2000-02-29 Baxter Travenol Lab Flexible cardiac valvular support prosthesis
US5061277A (en) 1986-08-06 1991-10-29 Baxter International Inc. Flexible cardiac valvular support prosthesis
US4830023A (en) 1987-11-27 1989-05-16 Medi-Tech, Incorporated Medical guidewire
US5350420A (en) 1989-07-31 1994-09-27 Baxter International Inc. Flexible annuloplasty ring and holder
US5261916A (en) 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5265601A (en) 1992-05-01 1993-11-30 Medtronic, Inc. Dual chamber cardiac pacing from a single electrode
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US5474557A (en) 1993-09-21 1995-12-12 Mai; Christian Multibranch osteosynthesis clip with dynamic compression and self-retention
US5935161A (en) 1993-11-04 1999-08-10 C. R. Bard, Inc. Non-migrating vascular prosthesis and minimally invasive placement system therefor
US5733325A (en) 1993-11-04 1998-03-31 C. R. Bard, Inc. Non-migrating vascular prosthesis and minimally invasive placement system
US6077297A (en) 1993-11-04 2000-06-20 C. R. Bard, Inc. Non-migrating vascular prosthesis and minimally invasive placement system therefor
US5891193A (en) 1993-11-04 1999-04-06 C.R. Bard, Inc. Non-migrating vascular prosthesis and minimally invasive placement system therefor
US6027517A (en) 1994-02-24 2000-02-22 Radiance Medical Systems, Inc. Fixed focal balloon for interactive angioplasty and stent implantation catheter with focalized balloon
US5562698A (en) 1994-03-09 1996-10-08 Cook Incorporated Intravascular treatment system
US5584867A (en) 1994-04-05 1996-12-17 Ela Medical S.A. Method and apparatus for controlling a double atrial triple chamber cardiac pacemaker having a fallback mode
US5514161A (en) 1994-04-05 1996-05-07 Ela Medical S.A. Methods and apparatus for controlling atrial stimulation in a double atrial triple chamber cardiac pacemaker
US5899882A (en) 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
US5554177A (en) 1995-03-27 1996-09-10 Medtronic, Inc. Method and apparatus to optimize pacing based on intensity of acoustic signal
US5676671A (en) 1995-04-12 1997-10-14 Inoue; Kanji Device for introducing an appliance to be implanted into a catheter
US5601600A (en) 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US6352553B1 (en) 1995-12-14 2002-03-05 Gore Enterprise Holdings, Inc. Stent-graft deployment apparatus and method
US5908404A (en) 1996-05-13 1999-06-01 Elliott; James B. Methods for inserting an implant
US6077295A (en) 1996-07-15 2000-06-20 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system
US5824071A (en) 1996-09-16 1998-10-20 Circulation, Inc. Apparatus for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5895391A (en) 1996-09-27 1999-04-20 Target Therapeutics, Inc. Ball lock joint and introducer for vaso-occlusive member
US6395017B1 (en) 1996-11-15 2002-05-28 C. R. Bard, Inc. Endoprosthesis delivery catheter with sequential stage control
US6254628B1 (en) 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US6352561B1 (en) 1996-12-23 2002-03-05 W. L. Gore & Associates Implant deployment apparatus
US6171320B1 (en) 1996-12-25 2001-01-09 Niti Alloys Technologies Ltd. Surgical clip
US5961545A (en) 1997-01-17 1999-10-05 Meadox Medicals, Inc. EPTFE graft-stent composite device
US6015402A (en) 1997-03-07 2000-01-18 Sahota; Harvinder Wire perfusion catheter
US5978705A (en) 1997-03-14 1999-11-02 Uab Research Foundation Method and apparatus for treating cardiac arrhythmia using auxiliary pulse
US6275730B1 (en) 1997-03-14 2001-08-14 Uab Research Foundation Method and apparatus for treating cardiac arrythmia
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US5984944A (en) 1997-09-12 1999-11-16 B. Braun Medical, Inc. Introducer for an expandable vascular occlusion device
US6096064A (en) 1997-09-19 2000-08-01 Intermedics Inc. Four chamber pacer for dilated cardiomyopthy
US5928258A (en) 1997-09-26 1999-07-27 Corvita Corporation Method and apparatus for loading a stent or stent-graft into a delivery sheath
US6099552A (en) 1997-11-12 2000-08-08 Boston Scientific Corporation Gastrointestinal copression clips
US6190406B1 (en) 1998-01-09 2001-02-20 Nitinal Development Corporation Intravascular stent having tapered struts
US6503271B2 (en) 1998-01-09 2003-01-07 Cordis Corporation Intravascular device with improved radiopacity
US6129755A (en) 1998-01-09 2000-10-10 Nitinol Development Corporation Intravascular stent having an improved strut configuration
US6342067B1 (en) 1998-01-09 2002-01-29 Nitinol Development Corporation Intravascular stent having curved bridges for connecting adjacent hoops
US6345198B1 (en) 1998-01-23 2002-02-05 Pacesetter, Inc. Implantable stimulation system for providing dual bipolar sensing using an electrode positioned in proximity to the tricuspid valve and programmable polarity
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US6099549A (en) 1998-07-03 2000-08-08 Cordis Corporation Vascular filter for controlled release
US6709425B2 (en) 1998-09-30 2004-03-23 C. R. Bard, Inc. Vascular inducing implants
US6267783B1 (en) 1998-11-09 2001-07-31 Cordis Corporation Stent which is easily recaptured and repositioned within the body
US6629534B1 (en) 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US6183512B1 (en) 1999-04-16 2001-02-06 Edwards Lifesciences Corporation Flexible annuloplasty system
US6602289B1 (en) 1999-06-08 2003-08-05 S&A Rings, Llc Annuloplasty rings of particular use in surgery for the mitral valve
US6626899B2 (en) 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
US20020035361A1 (en) 1999-06-25 2002-03-21 Houser Russell A. Apparatus and methods for treating tissue
US6210432B1 (en) 1999-06-29 2001-04-03 Jan Otto Solem Device and method for treatment of mitral insufficiency
US20010018611A1 (en) 1999-06-30 2001-08-30 Solem Jan Otto Method and device for treatment of mitral insufficiency
US20010049558A1 (en) 2000-01-14 2001-12-06 Liddicoat John R. Tissue annuloplasty band and apparatus and method for fashioning, sizing and implanting the same
US6537314B2 (en) 2000-01-31 2003-03-25 Ev3 Santa Rosa, Inc. Percutaneous mitral annuloplasty and cardiac reinforcement
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US20010044568A1 (en) 2000-01-31 2001-11-22 Langberg Jonathan J. Endoluminal ventricular retention
US20020103533A1 (en) 2000-01-31 2002-08-01 Langberg Jonathan J. Percutaneous mitral annuloplasty and cardiac reinforcement
US20020016628A1 (en) 2000-01-31 2002-02-07 Langberg Jonathan J. Percutaneous mitral annuloplasty with hemodynamic monitoring
US20020151961A1 (en) 2000-01-31 2002-10-17 Lashinski Randall T. Medical system and method for remodeling an extravascular tissue structure
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
US6358195B1 (en) 2000-03-09 2002-03-19 Neoseed Technology Llc Method and apparatus for loading radioactive seeds into brachytherapy needles
US6569198B1 (en) 2000-03-31 2003-05-27 Richard A. Wilson Mitral or tricuspid valve annuloplasty prosthetic device
US6442427B1 (en) 2000-04-27 2002-08-27 Medtronic, Inc. Method and system for stimulating a mammalian heart
US6589208B2 (en) 2000-06-20 2003-07-08 Applied Medical Resources Corporation Self-deploying catheter assembly
US20020042621A1 (en) 2000-06-23 2002-04-11 Liddicoat John R. Automated annular plication for mitral valve repair
US20020049468A1 (en) 2000-06-30 2002-04-25 Streeter Richard B. Intravascular filter with debris entrapment mechanism
US20020042651A1 (en) 2000-06-30 2002-04-11 Liddicoat John R. Method and apparatus for performing a procedure on a cardiac valve
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US20020055774A1 (en) 2000-09-07 2002-05-09 Liddicoat John R. Fixation band for affixing a prosthetic heart valve to tissue
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US20020095167A1 (en) 2000-10-23 2002-07-18 Liddicoat John R. Automated annular plication for mitral valve repair
US20020065554A1 (en) 2000-10-25 2002-05-30 Streeter Richard B. Mitral shield
US20020138044A1 (en) 2000-10-27 2002-09-26 Streeter Richard B. Intracardiovascular access (ICVATM) system
US20020087173A1 (en) 2000-12-28 2002-07-04 Alferness Clifton A. Mitral valve constricting device, system and method
US20020103532A1 (en) 2001-01-30 2002-08-01 Langberg Jonathan J. Transluminal mitral annuloplasty
US6643546B2 (en) 2001-02-13 2003-11-04 Quetzal Biomedical, Inc. Multi-electrode apparatus and method for treatment of congestive heart failure
US6733521B2 (en) 2001-04-11 2004-05-11 Trivascular, Inc. Delivery system and method for endovascular graft
US6718985B2 (en) 2001-04-24 2004-04-13 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty using local plications
US20020161377A1 (en) 2001-04-27 2002-10-31 Dmitry Rabkin Apparatus for delivering, repositioning and/or retrieving self-expanding stents
US6800090B2 (en) 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6966926B2 (en) 2001-05-14 2005-11-22 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method
US6629994B2 (en) 2001-06-11 2003-10-07 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6721598B1 (en) 2001-08-31 2004-04-13 Pacesetter, Inc. Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US6716158B2 (en) 2001-09-07 2004-04-06 Mardil, Inc. Method and apparatus for external stabilization of the heart
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US6960229B2 (en) 2002-01-30 2005-11-01 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
US6793673B2 (en) 2002-12-26 2004-09-21 Cardiac Dimensions, Inc. System and method to effect mitral valve annulus of a heart
US6964683B2 (en) 2002-12-26 2005-11-15 Cardiac Dimensions, Inc. System and method to effect the mitral valve annulus of a heart

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
Clifton Alferness, et al. U.S. Appl. No. 11/467,105 entitled "Device and method for modifying the shape of a body organ," filed Aug. 24, 2006 (WSGR Reference No. 29912-705.304).
Gray, H. Anatomy of the Human Body. The Systemic Veins. Philadelphia: Lea & Febiger, 1918; Bartleby.com. 2000. Available at www.bartleby.com/107/. Accessed Jun. 7, 2006.
Gregory Nieminen. U.S. Appl. No. 11/458,040, entitled "Mitral Valve Annuloplasty Device with Twisted Anchor," filed Jul. 17, 2006 (WSGR Reference No. 29912-733.501).
Gregory Nieminen. U.S. Appl. No. 11/458,042, entitled "Mitral Valve Annuloplasty Device with Wide Anchor," filed Jul. 17, 2006 (WSGR Reference No. 29912-733.502).
Heartsite.com. Echocardiogram. 1999; p. 1-4. A.S.M. Systems Inc. Available at: http://www.heartsite.com/html/echocardiogram.html. Accessed Jul. 1, 2005.
Lucas Gordon, et al. U.S. Appl. No. 11/383,115 entitled "Tissue Shaping Device with Integral Connector and Crimp," filed May 12, 2006 (WSGR Reference No. 29912-730.401).
Mark L. Mathis, et al. U.S. Appl. No. 11/279,352, entitled "Mitral Valve Annuloplasty Device with Vena Cava Anchor," filed Apr. 11, 2006 (WSGR Reference No. 29912-739.201).
Mathis et al., U.S. Patent Application entitled: "Device and Method for Modifying the Shape of a Body Organ", U.S. Appl. No. 10/429,172 filed May 2, 2003.
Mathis, Mark; U.S. Appl. No. 11/655,710, entitled "Mitral Valve Device Using Conditioned Shape Memory Alloy," filed Jan. 18, 2007 (SLG # 10057-714.301).
Papageorgiou, P., et al., "Coronary Sinus Pacing Prevents Induction of Atrial Fibrillation," Circulation 96: 1893-1898, Sep. 16, 1977.

Cited By (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8460173B2 (en) 1997-01-02 2013-06-11 Edwards Lifesciences, Llc Heart wall tension reduction apparatus and method
US8267852B2 (en) 1997-01-02 2012-09-18 Edwards Lifesciences, Llc Heart wall tension reduction apparatus and method
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US20040102840A1 (en) * 1999-06-30 2004-05-27 Solem Jan Otto Method and device for treatment of mitral insufficiency
US20100100175A1 (en) * 2001-11-01 2010-04-22 David Reuter Adjustable Height Focal Tissue Deflector
US8439971B2 (en) 2001-11-01 2013-05-14 Cardiac Dimensions, Inc. Adjustable height focal tissue deflector
US8172898B2 (en) 2001-12-05 2012-05-08 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US20110035000A1 (en) * 2002-01-30 2011-02-10 Cardiac Dimensions, Inc. Tissue Shaping Device
US10327900B2 (en) 2002-01-30 2019-06-25 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9956076B2 (en) 2002-01-30 2018-05-01 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US10206778B2 (en) 2002-01-30 2019-02-19 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9827100B2 (en) 2002-01-30 2017-11-28 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9597186B2 (en) 2002-01-30 2017-03-21 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US10052205B2 (en) 2002-01-30 2018-08-21 Cardiac Dimensions Pty. Ltd. Fixed anchor and pull mitral valve device and method
US8974525B2 (en) 2002-01-30 2015-03-10 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9827099B2 (en) 2002-01-30 2017-11-28 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9827098B2 (en) 2002-01-30 2017-11-28 Cardiac Dimensions Pty. Ltd. Fixed anchor and pull mitral valve device and method
US9320600B2 (en) 2002-01-30 2016-04-26 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US10456258B2 (en) 2002-05-08 2019-10-29 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US10456257B2 (en) 2002-05-08 2019-10-29 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US7666224B2 (en) 2002-11-12 2010-02-23 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US20110066234A1 (en) * 2002-12-05 2011-03-17 Gordon Lucas S Percutaneous Mitral Valve Annuloplasty Delivery System
US20100280602A1 (en) * 2003-02-03 2010-11-04 Cardiac Dimensions, Inc. Mitral Valve Device Using Conditioned Shape Memory Alloy
US11452603B2 (en) 2003-05-02 2022-09-27 Cardiac Dimensions Pty. Ltd. Device and method for modifying the shape of a body organ
US11311380B2 (en) 2003-05-02 2022-04-26 Cardiac Dimensions Pty. Ltd. Device and method for modifying the shape of a body organ
US20050010240A1 (en) * 2003-06-05 2005-01-13 Cardiac Dimensions Inc., A Washington Corporation Device and method for modifying the shape of a body organ
US9283065B2 (en) 2003-11-12 2016-03-15 Nitinol Devices And Components, Inc. Medical device anchor and delivery system
US8409239B2 (en) 2003-11-12 2013-04-02 Nitinol Devices And Components, Inc. Medical device anchor and delivery system
US8398672B2 (en) 2003-11-12 2013-03-19 Nitinol Devices And Components, Inc. Method for anchoring a medical device
US11318016B2 (en) 2003-12-19 2022-05-03 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US9956077B2 (en) 2003-12-19 2018-05-01 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US10166102B2 (en) 2003-12-19 2019-01-01 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US11109971B2 (en) 2003-12-19 2021-09-07 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US10449048B2 (en) 2003-12-19 2019-10-22 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
US11033257B2 (en) 2005-01-20 2021-06-15 Cardiac Dimensions Pty. Ltd. Tissue shaping device
US9526613B2 (en) 2005-03-17 2016-12-27 Valtech Cardio Ltd. Mitral valve treatment techniques
US10561498B2 (en) 2005-03-17 2020-02-18 Valtech Cardio, Ltd. Mitral valve treatment techniques
US11497605B2 (en) 2005-03-17 2022-11-15 Valtech Cardio Ltd. Mitral valve treatment techniques
US10695046B2 (en) 2005-07-05 2020-06-30 Edwards Lifesciences Corporation Tissue anchor and anchoring system
US9839515B2 (en) 2005-12-22 2017-12-12 Symetis, SA Stent-valves for valve replacement and associated methods and systems for surgery
US9216082B2 (en) 2005-12-22 2015-12-22 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US20090171432A1 (en) * 2005-12-22 2009-07-02 Von Segesser Ludwig K Stent-valves for valve replacement and associated methods and systems for surgery
US10314701B2 (en) 2005-12-22 2019-06-11 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US10299922B2 (en) 2005-12-22 2019-05-28 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US10265167B2 (en) 2005-12-22 2019-04-23 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US11285005B2 (en) 2006-07-17 2022-03-29 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US9872769B2 (en) 2006-12-05 2018-01-23 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US9974653B2 (en) 2006-12-05 2018-05-22 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US10357366B2 (en) 2006-12-05 2019-07-23 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US9883943B2 (en) 2006-12-05 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US11344414B2 (en) 2006-12-05 2022-05-31 Valtech Cardio Ltd. Implantation of repair devices in the heart
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
US9351830B2 (en) 2006-12-05 2016-05-31 Valtech Cardio, Ltd. Implant and anchor placement
US10363137B2 (en) 2006-12-05 2019-07-30 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US8926695B2 (en) 2006-12-05 2015-01-06 Valtech Cardio, Ltd. Segmented ring placement
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11154398B2 (en) 2008-02-26 2021-10-26 JenaValve Technology. Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11660191B2 (en) 2008-03-10 2023-05-30 Edwards Lifesciences Corporation Method to reduce mitral regurgitation
US9192472B2 (en) 2008-06-16 2015-11-24 Valtec Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
US20110166649A1 (en) * 2008-06-16 2011-07-07 Valtech Cardio Ltd. Annuloplasty devices and methods of deliver therefor
US8250960B2 (en) 2008-08-11 2012-08-28 Cardiac Dimensions, Inc. Catheter cutting tool
US10470882B2 (en) 2008-12-22 2019-11-12 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US10856986B2 (en) 2008-12-22 2020-12-08 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US11116634B2 (en) 2008-12-22 2021-09-14 Valtech Cardio Ltd. Annuloplasty implants
US9662209B2 (en) 2008-12-22 2017-05-30 Valtech Cardio, Ltd. Contractible annuloplasty structures
US9713530B2 (en) 2008-12-22 2017-07-25 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US11202709B2 (en) 2009-02-17 2021-12-21 Valtech Cardio Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US10350068B2 (en) 2009-02-17 2019-07-16 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US11185412B2 (en) 2009-05-04 2021-11-30 Valtech Cardio Ltd. Deployment techniques for annuloplasty implants
US10548729B2 (en) 2009-05-04 2020-02-04 Valtech Cardio, Ltd. Deployment techniques for annuloplasty ring and over-wire rotation tool
US11844665B2 (en) 2009-05-04 2023-12-19 Edwards Lifesciences Innovation (Israel) Ltd. Deployment techniques for annuloplasty structure
US11076958B2 (en) 2009-05-04 2021-08-03 Valtech Cardio, Ltd. Annuloplasty ring delivery catheters
US11766327B2 (en) 2009-05-04 2023-09-26 Edwards Lifesciences Innovation (Israel) Ltd. Implantation of repair chords in the heart
US9474606B2 (en) 2009-05-04 2016-10-25 Valtech Cardio, Ltd. Over-wire implant contraction methods
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US9937042B2 (en) 2009-05-07 2018-04-10 Valtech Cardio, Ltd. Multiple anchor delivery tool
US10856987B2 (en) 2009-05-07 2020-12-08 Valtech Cardio, Ltd. Multiple anchor delivery tool
US11723774B2 (en) 2009-05-07 2023-08-15 Edwards Lifesciences Innovation (Israel) Ltd. Multiple anchor delivery tool
US9592122B2 (en) 2009-05-07 2017-03-14 Valtech Cardio, Ltd Annuloplasty ring with intra-ring anchoring
US9119719B2 (en) 2009-05-07 2015-09-01 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US9968454B2 (en) 2009-10-29 2018-05-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of artificial chordae
US11141271B2 (en) 2009-10-29 2021-10-12 Valtech Cardio Ltd. Tissue anchor for annuloplasty device
US11617652B2 (en) 2009-10-29 2023-04-04 Edwards Lifesciences Innovation (Israel) Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US10751184B2 (en) 2009-10-29 2020-08-25 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US9414921B2 (en) 2009-10-29 2016-08-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US10098737B2 (en) 2009-10-29 2018-10-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9622861B2 (en) 2009-12-02 2017-04-18 Valtech Cardio, Ltd. Tool for actuating an adjusting mechanism
US11602434B2 (en) 2009-12-02 2023-03-14 Edwards Lifesciences Innovation (Israel) Ltd. Systems and methods for tissue adjustment
US10492909B2 (en) 2009-12-02 2019-12-03 Valtech Cardio, Ltd. Tool for actuating an adjusting mechanism
US10548726B2 (en) 2009-12-08 2020-02-04 Cardiovalve Ltd. Rotation-based anchoring of an implant
US11141268B2 (en) 2009-12-08 2021-10-12 Cardiovalve Ltd. Prosthetic heart valve with upper and lower skirts
US11839541B2 (en) 2009-12-08 2023-12-12 Cardiovalve Ltd. Prosthetic heart valve with upper skirt
US11351026B2 (en) 2009-12-08 2022-06-07 Cardiovalve Ltd. Rotation-based anchoring of an implant
US10231831B2 (en) 2009-12-08 2019-03-19 Cardiovalve Ltd. Folding ring implant for heart valve
DE212010000134U1 (en) 2010-04-28 2012-04-24 Torus Medical Ltd. Device for extending a hose
US9661992B2 (en) 2010-04-28 2017-05-30 Torus Medical Ltd. Method and apparatus for extending a tube
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US9931206B2 (en) 2010-07-09 2018-04-03 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US11259922B2 (en) 2010-07-09 2022-03-01 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US11883283B2 (en) 2010-07-09 2024-01-30 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US11311377B2 (en) 2010-07-09 2022-04-26 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US11446140B2 (en) 2010-07-09 2022-09-20 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US11259921B2 (en) 2010-07-09 2022-03-01 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US10792152B2 (en) 2011-06-23 2020-10-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US10363136B2 (en) 2011-11-04 2019-07-30 Valtech Cardio, Ltd. Implant having multiple adjustment mechanisms
US20130116780A1 (en) * 2011-11-04 2013-05-09 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US11197759B2 (en) 2011-11-04 2021-12-14 Valtech Cardio Ltd. Implant having multiple adjusting mechanisms
US8858623B2 (en) * 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US9775709B2 (en) 2011-11-04 2017-10-03 Valtech Cardio, Ltd. Implant having multiple adjustable mechanisms
US9265608B2 (en) 2011-11-04 2016-02-23 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US11857415B2 (en) 2011-11-08 2024-01-02 Edwards Lifesciences Innovation (Israel) Ltd. Controlled steering functionality for implant-delivery tool
US9724192B2 (en) 2011-11-08 2017-08-08 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US10568738B2 (en) 2011-11-08 2020-02-25 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9011531B2 (en) 2012-02-13 2015-04-21 Mitraspan, Inc. Method and apparatus for repairing a mitral valve
US10076414B2 (en) 2012-02-13 2018-09-18 Mitraspan, Inc. Method and apparatus for repairing a mitral valve
US11395648B2 (en) 2012-09-29 2022-07-26 Edwards Lifesciences Corporation Plication lock delivery system and method of use thereof
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
US10893939B2 (en) 2012-10-23 2021-01-19 Valtech Cardio, Ltd. Controlled steering functionality for implant delivery tool
US11344310B2 (en) 2012-10-23 2022-05-31 Valtech Cardio Ltd. Percutaneous tissue anchor techniques
US9949828B2 (en) 2012-10-23 2018-04-24 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US11890190B2 (en) 2012-10-23 2024-02-06 Edwards Lifesciences Innovation (Israel) Ltd. Location indication system for implant-delivery tool
US10610360B2 (en) 2012-12-06 2020-04-07 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US11583400B2 (en) 2012-12-06 2023-02-21 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for guided advancement of a tool
US11844691B2 (en) 2013-01-24 2023-12-19 Cardiovalve Ltd. Partially-covered prosthetic valves
US10918374B2 (en) 2013-02-26 2021-02-16 Edwards Lifesciences Corporation Devices and methods for percutaneous tricuspid valve repair
US11793505B2 (en) 2013-02-26 2023-10-24 Edwards Lifesciences Corporation Devices and methods for percutaneous tricuspid valve repair
US10449333B2 (en) 2013-03-14 2019-10-22 Valtech Cardio, Ltd. Guidewire feeder
US11534583B2 (en) 2013-03-14 2022-12-27 Valtech Cardio Ltd. Guidewire feeder
US11490896B2 (en) * 2013-03-15 2022-11-08 Covidien Lp Delivery and detachment mechanisms for vascular implants
US10682232B2 (en) 2013-03-15 2020-06-16 Edwards Lifesciences Corporation Translation catheters, systems, and methods of use thereof
US11890194B2 (en) 2013-03-15 2024-02-06 Edwards Lifesciences Corporation Translation catheters, systems, and methods of use thereof
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US11744573B2 (en) 2013-08-31 2023-09-05 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US10918373B2 (en) 2013-08-31 2021-02-16 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US11766263B2 (en) 2013-10-23 2023-09-26 Edwards Lifesciences Innovation (Israel) Ltd. Anchor magazine
US10299793B2 (en) 2013-10-23 2019-05-28 Valtech Cardio, Ltd. Anchor magazine
US10265170B2 (en) 2013-12-26 2019-04-23 Valtech Cardio, Ltd. Implantation of flexible implant
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US10973637B2 (en) 2013-12-26 2021-04-13 Valtech Cardio, Ltd. Implantation of flexible implant
US10195030B2 (en) 2014-10-14 2019-02-05 Valtech Cardio, Ltd. Leaflet-restraining techniques
US11071628B2 (en) 2014-10-14 2021-07-27 Valtech Cardio, Ltd. Leaflet-restraining techniques
US11801135B2 (en) 2015-02-05 2023-10-31 Cardiovalve Ltd. Techniques for deployment of a prosthetic valve
US10925610B2 (en) 2015-03-05 2021-02-23 Edwards Lifesciences Corporation Devices for treating paravalvular leakage and methods use thereof
US10765514B2 (en) 2015-04-30 2020-09-08 Valtech Cardio, Ltd. Annuloplasty technologies
US11020227B2 (en) 2015-04-30 2021-06-01 Valtech Cardio, Ltd. Annuloplasty technologies
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US10828160B2 (en) 2015-12-30 2020-11-10 Edwards Lifesciences Corporation System and method for reducing tricuspid regurgitation
US10751182B2 (en) 2015-12-30 2020-08-25 Edwards Lifesciences Corporation System and method for reshaping right heart
US11890193B2 (en) 2015-12-30 2024-02-06 Edwards Lifesciences Corporation System and method for reducing tricuspid regurgitation
US11660192B2 (en) 2015-12-30 2023-05-30 Edwards Lifesciences Corporation System and method for reshaping heart
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US10702274B2 (en) 2016-05-26 2020-07-07 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US11540835B2 (en) 2016-05-26 2023-01-03 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US10959845B2 (en) 2016-07-08 2021-03-30 Valtech Cardio, Ltd. Adjustable annuloplasty device with alternating peaks and troughs
US10226342B2 (en) 2016-07-08 2019-03-12 Valtech Cardio, Ltd. Adjustable annuloplasty device with alternating peaks and troughs
US11779458B2 (en) 2016-08-10 2023-10-10 Cardiovalve Ltd. Prosthetic valve with leaflet connectors
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
US11399939B2 (en) 2017-03-08 2022-08-02 Cardiac Dimensions Pty. Ltd. Methods and devices for reducing paravalvular leakage
US10390953B2 (en) 2017-03-08 2019-08-27 Cardiac Dimensions Pty. Ltd. Methods and devices for reducing paravalvular leakage
US11883611B2 (en) 2017-04-18 2024-01-30 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
US11045627B2 (en) 2017-04-18 2021-06-29 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
WO2019051587A1 (en) * 2017-09-12 2019-03-21 Cheema Asim Apparatus and system for changing mitral valve annulus geometry
US11534301B2 (en) 2017-09-12 2022-12-27 Asim Cheema Apparatus and system for changing mitral valve annulus geometry
US10835221B2 (en) 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US11832784B2 (en) 2017-11-02 2023-12-05 Edwards Lifesciences Innovation (Israel) Ltd. Implant-cinching devices and systems
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
US11779463B2 (en) 2018-01-24 2023-10-10 Edwards Lifesciences Innovation (Israel) Ltd. Contraction of an annuloplasty structure
US11666442B2 (en) 2018-01-26 2023-06-06 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
US11026791B2 (en) 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11285003B2 (en) 2018-03-20 2022-03-29 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof
US11701228B2 (en) 2018-03-20 2023-07-18 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11123191B2 (en) 2018-07-12 2021-09-21 Valtech Cardio Ltd. Annuloplasty systems and locking tools therefor
US11890191B2 (en) 2018-07-12 2024-02-06 Edwards Lifesciences Innovation (Israel) Ltd. Fastener and techniques therefor
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
US11819411B2 (en) 2019-10-29 2023-11-21 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty and tissue anchor technologies
US11596771B2 (en) 2020-12-14 2023-03-07 Cardiac Dimensions Pty. Ltd. Modular pre-loaded medical implants and delivery systems
US11931253B2 (en) 2021-01-26 2024-03-19 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: ball-slide attachment
US11931261B2 (en) 2022-02-17 2024-03-19 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof

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AU2003224656B2 (en) 2008-05-15
ES2321920T3 (en) 2009-06-15
US20050065598A1 (en) 2005-03-24
DE60326124D1 (en) 2009-03-26
CA2477646A1 (en) 2003-09-25
EP1482868A4 (en) 2006-08-30
AU2003224656A1 (en) 2003-09-29
US20030171806A1 (en) 2003-09-11
US6797001B2 (en) 2004-09-28
ATE422346T1 (en) 2009-02-15
CA2477646C (en) 2012-11-13
WO2003077800A1 (en) 2003-09-25
EP1482868B1 (en) 2009-02-11
EP1482868A1 (en) 2004-12-08

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