US8177750B2 - Variable flow infusion pump system - Google Patents
Variable flow infusion pump system Download PDFInfo
- Publication number
- US8177750B2 US8177750B2 US12/621,799 US62179909A US8177750B2 US 8177750 B2 US8177750 B2 US 8177750B2 US 62179909 A US62179909 A US 62179909A US 8177750 B2 US8177750 B2 US 8177750B2
- Authority
- US
- United States
- Prior art keywords
- pump
- module
- infusion pump
- implantable infusion
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related, expires
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/141—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor with capillaries for restricting fluid flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16813—Flow controllers by controlling the degree of opening of the flow line
Definitions
- the means for varying the flow rate of the active substance between the chamber and the outlet may include an elongate insert having a longitudinally varying cross section along its length. Movement of this elongate insert may increase or decrease the flow rate of the active substance.
- the pump may also include a removable module including a bottom surface contacting the upper surface of the constant flow pump, an entry formed in the bottom surface in fluid communication with the exit opening of the housing, an exit in fluid communication with the entrance opening of the housing, a needle portion having a longitudinally varying cross section along its length disposed within a valve body, means for longitudinally moving the needle portion within the valve body, a fixed flow restrictor in fluid communication between the entry of the module and the valve body of the module, and first and second pressure sensors located on either side of the fixed flow restrictor.
- a removable module including a bottom surface contacting the upper surface of the constant flow pump, an entry formed in the bottom surface in fluid communication with the exit opening of the housing, an exit in fluid communication with the entrance opening of the housing, a needle portion having a longitudinally varying cross section along its length disposed within a valve body, means for longitudinally moving the needle portion within the valve body, a fixed flow restrictor in fluid communication between the entry of the module and the valve body of the module, and first and second pressure sensors located on
- a fluid dispelled from the active substance chamber by a force from the propellant chamber passes through the exit opening of the housing, through the entry of the module, into contact with the first pressure sensor, through the fixed flow restrictor, into contact with the second pressure sensor, through the valve body of the module, through the exit of the module, through the entrance opening of the housing, through the outlet duct, and through the catheter.
- FIG. 3 is an enlarged view of an attachment area of the pump shown in FIG. 1 .
- FIG. 11 b is a longitudinal cross sectional view of the variable flow resistor of FIG. 11 a , depicting the curvature of the capillary.
- FIG. 19 is a cross sectional view of a variable flow resistor in accordance with a third embodiment of the present invention with an insert eccentrically located.
- FIG. 36 is a cross sectional view of the pump and module depicted in FIG. 35 .
- pump 1310 preferably includes several elements which are similar in structure and function, and are thus labeled with like reference numerals within the 1300 series of numbers.
- pump 1310 is akin to the configuration set forth in pump 1210 .
- locking portion 1324 includes a threaded extension 1356 , which cooperate and engage threaded areas 1358 and 1360 of portions 1320 and 1322 , respectively.
- operation of the needle causes injection of the solution from the needle to pass into port 38 , through passage 44 , and into chamber 24 .
- the particular dimension and/or the patient's need may require such a process to be repeated at given intervals, for example, monthly, weekly, etc.
- pump 20 also includes an annular ring bolus port 46 covered by a second septum 48 .
- this port allows for direct introduction of a solution into outlet catheter 36 and to the specific target area of the body.
- This port is particularly useful when a patient requires additional or stronger medication, such as a single bolus injection, and/or when it is desired to test the flow path of catheter 36 .
- Such an injection is performed in a similar fashion to the above discussed injection into replenishment port 38 .
- an injection into bolus port 46 bypasses passage 44 , chamber 24 and resistor 32 , and provides direct access to catheter 36 . It is also contemplated to utilize bolus port 46 to withdraw fluid from the body.
- septum 40 and septum 48 may be situated so that only specifically designed injection needles may be used to inject into the respective ports.
- septum 48 may be situated relatively close to the bottom of port 46 and septum 40 may be situated a greater distance away from the bottom of port 38 .
- injection needle 42 is provided with an injection eye 43 , which is located above the tip of needle 42 .
- injection needle 50 is provided with an injection eye 51 located at or near its tip. This arrangement prevents needle 42 , which is typically utilized for replenishing chamber 24 with a long term supply of medication fluid, from being inadvertently used to inject its contents into bolus port 46 .
- FIGS. 9 , 10 a and 10 b show a first example of the first embodiment resistor 32 , where elastic filament 52 is located concentrically in resistor capillary 54 .
- This configuration forms a ring-shaped flow channel 56 through which fluid flows in a direction shown by arrow F.
- filament 52 includes a first end 58 attached to a stationary attachment 60 , and a second end 62 attached to a movable attachment 64 .
- Resistor 32 also has an effective length L extending between capillary entrance 66 to exit 68 , and an initial diameter D 1 (i.e.—2 times its radius R 1 ).
- capillary 54 has a diameter D 3 (i.e.—2 times its radius R 3 ). This will be similar throughout in the various other capillaries discussed herein.
- Attachment 64 in the first example, and attachments 60 , 64 in the second example may be moved by any means known to those of ordinary skill in the art.
- motors such as micro-motors, magnets, or other hydraulic, electrical or mechanical actuators.
- X15G By Elliptec Resonant Actuator of Dortmund, Germany.
- FIG. 13 A third example of the first embodiment of the present invention is shown in FIG. 13 .
- This example includes a capillary 154 that is divided into two sectors by a center wall 155 .
- Fluid is capable of flowing through capillary 154 by entering through entrance 166 and exiting through exit 168 , as depicted by fluid flow arrow F.
- An elastic filament 152 is fixed at its ends by fixation points 160 and 164 , and is wrapped around a magnetic element 170 at the approximate central portion of filament 152 .
- Repulsive magnetic forces are transmitted to magnetic element 170 by a corresponding magnetic counterpart 172 , having a similar polarity.
- movement of counterpart 172 results in the like movement of element 170 .
- pump 700 further includes a replenishment port 738 covered by a first septum 740 , and an annular ring bolus port 746 covered by a second ring shaped septum 748 .
- the utility of each of these ports is substantially identical to those of pump 20 .
- a passage 744 allows fluid injected into replenishment port 738 to be introduced into chamber 724 .
- specifically designed injection needles and correspondingly situated septa may be employed to increase safety, as discussed above.
- recess 766 is in fluid communication with outlet duct 734 , and hence outlet catheter 736 (best shown in FIG. 29 ).
- fluid will flow from chamber 724 through resistor 732 , and out of catheter 736 to a target site within the body.
- a particular tube having a suitable inner diameter should be selected.
- the tube should be capable of conforming to the preferable curved shape of capillary 754 .
- each of these elements preferably cooperates so that operation of motor 822 causes movement of cam 823 in order to actuate valve 821 , which in turn causes variations in the flow rate of an active substance from pump 800 to a patient.
- the preferred cam shown is simply oblong in shape, such that a rotation of same subjects valve 821 to contact with thinner to thicker sections of the cam, which causes the needed translation.
- module 820 preferably also allows for the monitoring of system temperature, battery voltage, and power supply voltage.
- the sensors utilized in monitoring these conditions are labeled with reference numerals 844 d , 844 e , and 844 f for clarity purposes in FIGS. 49A and 49B .
- Any suitable sensors may be employed for these purposes, and readings may be taken at any time interval. For example, one embodiment takes such readings every one (1) second to ensure the health of the system.
- the amount of medicament dispensed is therefore determined by multiplying the average flow rate (or real time flow rate) by the time at which the flow rate from pump 800 was such. All of the different time periods are accounted for and the overall amount is determined by adding each of these individual amounts together. As is discussed above, readings by sensors 830 and 831 may be taken at any interval, for example, every fifteen minutes. In order to maintain an average flow rate, these readings are taken and a correction of valve 821 position is only done when the flow rate deviates from the desired flow rate by a certain amount. For instance, is certain embodiments, a correction of the flow rate is made when the flow rate deviates by 10% of the overall flow rate.
Abstract
Description
V=(ΔpπR 2 4)/(8ηL)
V=[(Δpπ)(R 2 −R 1)3(R 2 +R 1)]/(8ηL)
V=[(Δpπ)(R 2 −R 1)3(R 2 +R 1)2.5]/(8ηL)
Claims (39)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/621,799 US8177750B2 (en) | 2005-05-10 | 2009-11-19 | Variable flow infusion pump system |
US13/338,773 US8915893B2 (en) | 2005-05-10 | 2011-12-28 | Variable flow infusion pump system |
US13/447,693 US20120203180A1 (en) | 2005-05-10 | 2012-04-16 | Variable flow infusion pump system |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/126,101 US8211060B2 (en) | 2005-05-10 | 2005-05-10 | Reduced size implantable pump |
US11/125,586 US8114055B2 (en) | 2005-05-10 | 2005-05-10 | Implantable pump with infinitely variable resistor |
US11/157,437 US20070005044A1 (en) | 2005-05-10 | 2005-06-21 | Implantable pump with infinitely variable resistor |
US11/601,586 US7637892B2 (en) | 2005-05-10 | 2006-11-17 | Variable flow infusion pump system |
US12/621,799 US8177750B2 (en) | 2005-05-10 | 2009-11-19 | Variable flow infusion pump system |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/601,586 Continuation US7637892B2 (en) | 2005-05-10 | 2006-11-17 | Variable flow infusion pump system |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/338,773 Continuation-In-Part US8915893B2 (en) | 2005-05-10 | 2011-12-28 | Variable flow infusion pump system |
US13/447,693 Continuation US20120203180A1 (en) | 2005-05-10 | 2012-04-16 | Variable flow infusion pump system |
Publications (2)
Publication Number | Publication Date |
---|---|
US20100069892A1 US20100069892A1 (en) | 2010-03-18 |
US8177750B2 true US8177750B2 (en) | 2012-05-15 |
Family
ID=39430323
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/601,586 Expired - Fee Related US7637892B2 (en) | 2005-05-10 | 2006-11-17 | Variable flow infusion pump system |
US12/621,799 Expired - Fee Related US8177750B2 (en) | 2005-05-10 | 2009-11-19 | Variable flow infusion pump system |
US13/447,693 Abandoned US20120203180A1 (en) | 2005-05-10 | 2012-04-16 | Variable flow infusion pump system |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/601,586 Expired - Fee Related US7637892B2 (en) | 2005-05-10 | 2006-11-17 | Variable flow infusion pump system |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/447,693 Abandoned US20120203180A1 (en) | 2005-05-10 | 2012-04-16 | Variable flow infusion pump system |
Country Status (8)
Country | Link |
---|---|
US (3) | US7637892B2 (en) |
EP (1) | EP2083905A4 (en) |
JP (1) | JP5264757B2 (en) |
KR (1) | KR101426340B1 (en) |
AU (1) | AU2007322061B2 (en) |
CA (2) | CA2792541C (en) |
MX (1) | MX2009005079A (en) |
WO (1) | WO2008063541A2 (en) |
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US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
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AU2007322061B2 (en) | 2012-12-13 |
US7637892B2 (en) | 2009-12-29 |
MX2009005079A (en) | 2009-07-17 |
US20120203180A1 (en) | 2012-08-09 |
CA2792541A1 (en) | 2008-05-29 |
AU2007322061A1 (en) | 2008-05-29 |
WO2008063541A3 (en) | 2008-09-25 |
CA2792541C (en) | 2015-03-17 |
JP5264757B2 (en) | 2013-08-14 |
EP2083905A4 (en) | 2013-06-19 |
CA2670146C (en) | 2012-12-18 |
US20070112328A1 (en) | 2007-05-17 |
KR101426340B1 (en) | 2014-08-06 |
KR20090093990A (en) | 2009-09-02 |
JP2010509989A (en) | 2010-04-02 |
EP2083905A2 (en) | 2009-08-05 |
WO2008063541A2 (en) | 2008-05-29 |
CA2670146A1 (en) | 2008-05-29 |
US20100069892A1 (en) | 2010-03-18 |
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