US8808515B2 - Heterocyclic nitrogen containing polymers coated analyte monitoring device and methods of use - Google Patents
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- US8808515B2 US8808515B2 US11/701,138 US70113807A US8808515B2 US 8808515 B2 US8808515 B2 US 8808515B2 US 70113807 A US70113807 A US 70113807A US 8808515 B2 US8808515 B2 US 8808515B2
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- YLUZBQCYGCGKRS-UHFFFAOYSA-N CCCCC(CCC)C1=CC=NC=C1 Chemical compound CCCCC(CCC)C1=CC=NC=C1 YLUZBQCYGCGKRS-UHFFFAOYSA-N 0.000 description 5
- YNBMBLVREDUDTO-UHFFFAOYSA-N C=NC.CCC(C)CC Chemical compound C=NC.CCC(C)CC YNBMBLVREDUDTO-UHFFFAOYSA-N 0.000 description 4
- MKNJSWGAZNYIAK-UHFFFAOYSA-N CCCC(CC)C1=CC=NC=C1 Chemical compound CCCC(CC)C1=CC=NC=C1 MKNJSWGAZNYIAK-UHFFFAOYSA-N 0.000 description 2
- AOBIOSPNXBMOAT-UHFFFAOYSA-N C(COCC1CO1)OCC1CO1 Chemical compound C(COCC1CO1)OCC1CO1 AOBIOSPNXBMOAT-UHFFFAOYSA-N 0.000 description 1
- YHXYCIZBTSECRP-UHFFFAOYSA-N CCC(CC)C1=CC=NC=C1 Chemical compound CCC(CC)C1=CC=NC=C1 YHXYCIZBTSECRP-UHFFFAOYSA-N 0.000 description 1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
- A61B5/6849—Needles in combination with a needle set
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
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- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
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- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
- G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
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Abstract
Description
wherein the solid horizontal line represents a polymer backbone and n is a positive integer; and a counter electrode in electrochemical communication with the working electrode.
wherein n is a positive integer. In some embodiments, the crosslinker comprises a poly(ethylene glycol). In certain embodiments, the poly(ethylene glycol) is a poly(ethylene glycol) diglycidyl ether. In some embodiments, the membrane limits flux of glucose or lactate thereacross. In some embodiments, the membrane limits flux of glucose or lactose thereacross in vivo.
wherein n is a positive integer. In some embodiments, the crosslinker comprises a poly(ethylene glycol). In certain embodiments, the poly(ethylene glycol) is a poly(ethylene glycol) diglycidyl ether. In some embodiments, the membrane limits flux of glucose or lactate thereacross. In some embodiments, the membrane limits flux of glucose or lactose thereacross in vivo.
wherein the solid horizontal line represents a polymer backbone and n is a positive integer, (ii) at least one counter electrode, and (iii) at least one contact pad coupled to each of the working and counter electrodes, wherein the electrochemical sensor is adapted for implantation of a portion of the electrochemical sensor comprising the working and counter electrodes through skin; and an electrochemical sensor control unit comprising (i) a housing adapted for placement on skin; (ii) a plurality of conductive contacts disposed on the housing and configured for coupling to the contact pads of the electrochemical sensor; and (iii) an rf transmitter disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the electrochemical sensor.
wherein n is a positive integer. In some embodiments, the crosslinker comprises a poly(ethylene glycol). In certain embodiments, the poly(ethylene glycol) is a poly(ethylene glycol) diglycidyl ether. In some embodiments, the membrane limits flux of glucose or lactate thereacross. In some embodiments, the membrane limits flux of glucose or lactose thereacross in vivo.
wherein n is a positive integer. In some embodiments, the crosslinker comprises a poly(ethylene glycol). In certain embodiments, the poly(ethylene glycol) is a poly(ethylene glycol) diglycidyl ether. In some embodiments, the collecting data includes generating signals from the sensor and processing the signals into data. In some embodiments, the data includes the signals from the sensor. In certain embodiments, the method further includes activating an alarm if the data indicates an alarm condition. In certain embodiments, the method further includes administering a drug, such as insulin, in response to the data. In some embodiments, the method further includes obtaining a calibration value from a calibration device to calibrate the data. In some embodiments, the calibration device is coupled to the display unit. In some embodiments, the method further includes transmitting the calibration value from a transmitter in the display unit to a receiver in the sensor control unit.
wherein the horizontal line represents a polymer backbone and n is a positive integer from about 150 to about 15,000, including about 500 to about 12,000, about 750 to about 10,000, about 1,000 to about 9,000, such as about 1,500, 2,000, 2,500, 5,000, 7,000, etc. The term “heterocyclic nitrogen group” refers to a cyclic structure containing a nitrogen in a ring of the structure.
wherein the horizontal line represents a polymer backbone and n is a positive integer. A further example of such a poly(4-vinylpyridine) membrane has the following general formula, Formula III
wherein n is a positive integer, such as from about 1 to about 15, including about 8, 9, 10, 11, etc.
Claims (20)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/701,138 US8808515B2 (en) | 2007-01-31 | 2007-01-31 | Heterocyclic nitrogen containing polymers coated analyte monitoring device and methods of use |
JP2009548315A JP5324473B2 (en) | 2007-01-31 | 2008-01-31 | Specimen monitoring device coated with a heterocyclic nitrogen-containing polymer |
BRPI0808001-1A2A BRPI0808001A2 (en) | 2007-01-31 | 2008-01-31 | ANALYZED MONITORING DEVICE COVERED WITH POLYMER CONTAINING HETEROCYCLIC NITROGEN AND METHODS OF USE. |
EP08779558A EP2111159A4 (en) | 2007-01-31 | 2008-01-31 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
CN200880003612A CN101686809A (en) | 2007-01-31 | 2008-01-31 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
NZ578344A NZ578344A (en) | 2007-01-31 | 2008-01-31 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
AU2008230130A AU2008230130A1 (en) | 2007-01-31 | 2008-01-31 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
RU2009132504/14A RU2485887C2 (en) | 2007-01-31 | 2008-01-31 | Device for analyte monitoring, covered with heterocyclic nitrogen-containing polymer, and methods of its application |
CA002676241A CA2676241A1 (en) | 2007-01-31 | 2008-01-31 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
PCT/US2008/001364 WO2008118257A1 (en) | 2007-01-31 | 2008-01-31 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
TW097104358A TW200934445A (en) | 2007-01-31 | 2008-02-04 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
US14/463,453 US9096881B2 (en) | 2007-01-31 | 2014-08-19 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
US14/806,405 US9494545B2 (en) | 2007-01-31 | 2015-07-22 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
US15/347,603 US9777307B2 (en) | 2007-01-31 | 2016-11-09 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/701,138 US8808515B2 (en) | 2007-01-31 | 2007-01-31 | Heterocyclic nitrogen containing polymers coated analyte monitoring device and methods of use |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US14/463,453 Continuation US9096881B2 (en) | 2007-01-31 | 2014-08-19 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
Publications (2)
Publication Number | Publication Date |
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US20080179187A1 US20080179187A1 (en) | 2008-07-31 |
US8808515B2 true US8808515B2 (en) | 2014-08-19 |
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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US11/701,138 Active 2032-08-03 US8808515B2 (en) | 2007-01-31 | 2007-01-31 | Heterocyclic nitrogen containing polymers coated analyte monitoring device and methods of use |
US14/463,453 Active US9096881B2 (en) | 2007-01-31 | 2014-08-19 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
US14/806,405 Active US9494545B2 (en) | 2007-01-31 | 2015-07-22 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
US15/347,603 Active US9777307B2 (en) | 2007-01-31 | 2016-11-09 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
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US14/463,453 Active US9096881B2 (en) | 2007-01-31 | 2014-08-19 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
US14/806,405 Active US9494545B2 (en) | 2007-01-31 | 2015-07-22 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
US15/347,603 Active US9777307B2 (en) | 2007-01-31 | 2016-11-09 | Heterocyclic nitrogen containing polymer coated analyte monitoring device and methods of use |
Country Status (11)
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US (4) | US8808515B2 (en) |
EP (1) | EP2111159A4 (en) |
JP (1) | JP5324473B2 (en) |
CN (1) | CN101686809A (en) |
AU (1) | AU2008230130A1 (en) |
BR (1) | BRPI0808001A2 (en) |
CA (1) | CA2676241A1 (en) |
NZ (1) | NZ578344A (en) |
RU (1) | RU2485887C2 (en) |
TW (1) | TW200934445A (en) |
WO (1) | WO2008118257A1 (en) |
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US20140107436A1 (en) * | 2007-06-21 | 2014-04-17 | Abbott Diabetes Care Inc. | Health Monitor |
US9713442B2 (en) | 2008-09-30 | 2017-07-25 | Abbott Diabetes Care Inc. | Analyte sensors comprising leveling agents |
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NZ578344A (en) | 2011-07-29 |
TW200934445A (en) | 2009-08-16 |
JP5324473B2 (en) | 2013-10-23 |
CA2676241A1 (en) | 2008-10-02 |
JP2010517054A (en) | 2010-05-20 |
BRPI0808001A2 (en) | 2014-06-17 |
US20150038410A1 (en) | 2015-02-05 |
US20150323487A1 (en) | 2015-11-12 |
EP2111159A1 (en) | 2009-10-28 |
US20170114384A1 (en) | 2017-04-27 |
EP2111159A4 (en) | 2010-05-26 |
US9494545B2 (en) | 2016-11-15 |
CN101686809A (en) | 2010-03-31 |
AU2008230130A1 (en) | 2008-10-02 |
RU2009132504A (en) | 2011-03-10 |
US20080179187A1 (en) | 2008-07-31 |
WO2008118257A1 (en) | 2008-10-02 |
US9777307B2 (en) | 2017-10-03 |
US9096881B2 (en) | 2015-08-04 |
RU2485887C2 (en) | 2013-06-27 |
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