US9533047B2 - Delivery and formulation of engineered nucleic acids - Google Patents
Delivery and formulation of engineered nucleic acids Download PDFInfo
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- US9533047B2 US9533047B2 US14/337,513 US201414337513A US9533047B2 US 9533047 B2 US9533047 B2 US 9533047B2 US 201414337513 A US201414337513 A US 201414337513A US 9533047 B2 US9533047 B2 US 9533047B2
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Abstract
Description
TABLE 1 | |
Modified Nucleotides | Modified Nucleotide Combinations |
6-aza-cytidine | α-thio-cytidine/5-iodo-uridine |
2-thio-cytidine | α-thio-cytidine/N1-methyl-pseudo-uridine |
α-thio-cytidine | α-thio-cytidine/α-thio-uridine |
Pseudo-iso-cytidine | α-thio-cytidine/5-methyl-uridine |
5-aminoallyl-uridine | α-thio-cytidine/pseudo-uridine |
5-iodo-uridine | Pseudo-iso-cytidine/5-iodo-uridine |
N1-methyl-pseudouridine | Pseudo-iso-cytidine/N1-methyl-pseudo-uridine |
5,6-dihydrouridine | Pseudo-iso-cytidine/α-thio-uridine |
α-thio-uridine | Pseudo-iso-cytidine/5-methyl-uridine |
4-thio-uridine | Pseudo-iso-cytidine/Pseudo-uridine |
6-aza-uridine | Pyrrolo-cytidine |
5-hydroxy-uridine | Pyrrolo-cytidine/5-iodo-uridine |
Deoxy-thymidine | Pyrrolo-cytidine/N1-methyl-pseudo-uridine |
Pseudo-uridine | Pyrrolo-cytidine/α-thio-uridine |
Inosine | Pyrrolo-cytidine/5-methyl-uridine |
α-thio-guanosine | Pyrrolo-cytidine/Pseudo-uridine |
8-oxo-guanosine | 5-methyl-cytidine/5-iodo-uridine |
O6-methyl-guanosine | 5-methyl-cytidine/N1-methyl-pseudo-uridine |
7-deaza-guanosine | 5-methyl-cytidine/α-thio-uridine |
No modification | 5-methyl-cytidine/5-methyl-uridine |
N1-methyl-adenosine | 5-methyl-cytidine/Pseudo-uridine |
2-amino-6-Chloro-purine | 5-methyl-cytidine |
N6-methyl-2-amino- | 25% Pseudo-iso-cytidine |
purine | |
6-Chloro-purine | 25% N1-methyl-pseudo-uridine |
N6-methyl-adenosine | 25% N1-Methyl-pseudo-uridine/75%-pseudo- |
uridine | |
α-thio-adenosine | 5-methyl-uridine |
8-azido-adenosine | 5-iodo-cytidine |
7-deaza-adenosine | |
-
- 1. Thaw a tube of NEB 5-alpha Competent E. coli cells on ice for 10 minutes.
- 2. Add 1-5 μl containing 1 pg-100 ng of plasmid DNA to the cell mixture. Carefully flick the tube 4-5 times to mix cells and DNA. Do not vortex.
- 3. Place the mixture on ice for 30 minutes. Do not mix.
- 4. Heat shock at 42° C. for exactly 30 seconds. Do not mix.
- 5. Place on ice for 5 minutes. Do not mix.
- 6. Pipette 950 μl of room temperature SOC into the mixture.
- 7. Place at 37° C. for 60 minutes. Shake vigorously (250 rpm) or rotate.
- 8. Warm selection plates to 37° C.
- 9. Mix the cells thoroughly by flicking the tube and inverting.
- 10. Spread 50-100 μl of each dilution onto a selection plate and incubate overnight at 37° C.
TABLE 2 |
G-CSF Sequences |
SEQ | |
ID | |
NO | |
1 | cDNAsequence: |
ATGGCTGGACCTGCCACCCAGAGCCCCATGAAGCTGATGGCCCTGCA | |
GCTGCTGCTGTGGCACAGTGCACTCTGGACAGTGCAGGAAGCCACCC | |
CCCTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGC | |
TTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGA | |
GAAGCTGGTGAGTGAGTGTGCCACCTACAAGCTGTGCCACCCCGAGG | |
AGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG | |
AGCAGCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA | |
ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG | |
AAGGGATCTCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTG | |
GACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACT | |
GGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCT | |
| |
CATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCT | |
TGCCCAGCCCTGA | |
2 | cDNA having T7 polymerase site and Xba restriction site: |
TTGGACCCTCGTACAGAAGCTAATACGACTCACTATA | |
GGGAAATAAGAGAGAAAAGAAGAGTAAGAAGAAATATAAGAGCCACC | |
ATGGCTGGACCTGCCACCCAGAGCCCCATGAAGCTGATGGCCCTGCA | |
GCTGCTGCTGTGGCACAGTGCACTCTGGACAGTGCAGGAAGCCACCC | |
CCCTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGC | |
TTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGA | |
GAAGCTGGTGAGTGAGTGTGCCACCTACAAGCTGTGCCACCCCGAGG | |
AGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG | |
AGCAGCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA | |
ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG | |
AAGGGATCTCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTG | |
GACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACT | |
GGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCT | |
TCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCCTCC | |
CATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCT | |
| |
TGCCCTTCTTCTCTCCCTTGCACCTGTACCTCTTGGTCTTTGAATAA | |
AGCCTGAGTAGGAAGGCGGCCGCTCGAGCATGCATCTAGA | |
3 | Optimized sequence; containing T7 polymerase |
site and Xba restriction site | |
TTGGACCCTCGTACAGAAGCTAATACGACTCACTATAGGGAAATAAG | |
AGAGAAAAGAAGAGTAAGAAGAAATATAAGAGCCACC | |
ATGGCCCTGCAGTTGCTGCTTTGGCACTCGGCCCTCTGGACAGTCCA | |
AGAAGCGACTCCTCTCGGACCTGCCTCATCGTTGCCGCAGTCATTCC | |
TTTTGAAGTGTCTGGAGCAGGTGCGAAAGATTCAGGGCGATGGAGCC | |
GCACTCCAAGAGAAGCTCTGCGCGACATACAAACTTTGCCATCCCGA | |
GGAGCTCGTACTGCTCGGGCACAGCTTGGGGATTCCCTGGGCTCCTC | |
TCTCGTCCTGTCCGTCGCAGGCTTTGCAGTTGGCAGGGTGCCTTTCC | |
CAGCTCCACTCCGGTTTGTTCTTGTATCAGGGACTGCTGCAAGCCCT | |
TGAGGGAATCTCGCCAGAATTGGGCCCGACGCTGGACACGTTGCAGC | |
TCGACGTGGCGGATTTCGCAACAACCATCTGGCAGCAGATGGAGGAA | |
CTGGGGATGGCACCCGCGCTGCAGCCCACGCAGGGGGCAATGCCGGC | |
CTTTGCGTCCGCGTTTCAGCGCAGGGCGGGTGGAGTCCTCGTAGCGA | |
GCCACCTTCAATCATTTTTGGAAGTCTCGTACCGGGTGCTGAGACAT | |
| |
CTTCTTCTCTCCCTTGCACCTGTACCTCTTGGTCTTTGAATAAAGCC | |
TGAGTAGGAAGGCGGCCGCTCGAGCATGCA | |
4 | mRNA sequence (transcribed) |
CUCACUAUAGGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUA | |
AGAGCCACCA | |
AUGGCCCUGCAGUUGCUGCUUUGGCACUCGGCCCUCUGGACAGUCCA | |
AGAAGCGACUCCUCUCGGACCUGCCUCAUCGUUGCCGCAGUCAUUCC | |
UUUUGAAGUGUCUGGAGCAGGUGCGAAAGAUUCAGGGCGAUGGAGCC | |
GCACUCCAAGAGAAGCUCUGCGCGACAUACAAACUUUGCCAUCCCGA | |
GGAGCUCGUACUGCUCGGGCACAGCUUGGGGAUUCCCUGGGCUCCUC | |
UCUCGUCCUGUCCGUCGCAGGCUUUGCAGUUGGCAGGGUGCCUUUCC | |
CAGCUCCACUCCGGUUUGUUCUUGUAUCAGGGACUGCUGCAAGCCCU | |
UGAGGGAAUCUCGCCAGAAUUGGGCCCGACGCUGGACACGUUGCAGC | |
UCGACGUGGCGGAUUUCGCAACAACCAUCUGGCAGCAGAUGGAGGAA | |
CUGGGGAUGGCACCCGCGCUGCAGCCCACGCAGGGGGCAAUGCCGGC | |
CUUUGCGUCCGCGUUUCAGCGCAGGGCGGGUGGAGUCCUCGUAGCGA | |
GCCACCUUCAAUCAUUUUUGGAAGUCUCGUACCGGGUGCUGAGACAU | |
CUUGCGCAGCCGUGAGCCUUCUGCGGGGCUUGCCUUCUGGCCAUGCC | |
CUUCUUCUCUCCCUUGCACCUGUACCUCUUGGUCUUUGAAUAAAGCC | |
UGAGUAGGAAGGCGGCCGCUCGAGCAUGCAU | |
1. | Template cDNA | 1.0 | |
2. | 10x transcription buffer (400 mM Tris- | 2.0 | μl |
HCl pH 8.0, 190 mM MgCl2, 50 mM DTT, | |||
10 mM Spermidine) | |||
3. | Custom NTPs (25 mM each) | 7.2 | |
4. | RNase Inhibitor | 20 | |
5. | T7 RNA polymerase | 3000 | |
6. | |
Up to 20.0 μl. and |
7. | Incubation at 37° C. for 3 hr-5 hrs. | |
TABLE 3 |
Formulations |
Formulation # | Lipid | Lipid/RNA wt/wt | Mean size (nm) | |
NPA-001-1 | DLin-KC2- |
10 | 155 nm | |
PDI: 0.08 | ||||
NPA-001-1 aP | DLin-KC2- |
10 | 141 nm | |
PDI: 0.14 | ||||
NPA-002-1 | DLin-KC2- |
15 | 140 nm | |
PDI: 0.11 | ||||
NPA-002-1 aP | DLin-KC2- |
15 | 125 nm | |
PDI: 0.12 | ||||
NPA-003-1 | DLin-KC2- |
20 | 114 nm | |
PDI: 0.08 | ||||
NPA-003-1 aP | DLin-KC2- |
20 | 104 nm | |
PDI: 0.06 | ||||
NPA-005-1 | 98N12-5 | 15 | 127 nm | |
PDI: 0.12 | ||||
NPA-005-1 aP | 98N12-5 | 15 | 134 nm | |
PDI: 0.17 | ||||
NPA-006-1 | |
20 | 126 nm | |
PDI: 0.08 | ||||
NPA-006-1 | 98N12 | 20 | 118 nm | |
PDI: 0.13 | ||||
TABLE 4 |
Formulations |
Formulation # | NPA-003 | NPA-005 | |
Lipid | DLin-KC2-DMA | 98N12-5 | |
Lipid/ |
20 | 15 | |
wt/wt | |||
Mean size | 114 nm | 106 nm | |
PDI: 0.08 | PDI: 0.12 | ||
TABLE 5 |
Concentration and MFI |
MFI mCherry |
Formulation | NPA-003 | NPA-005 | |
25 | ng/well | 11963.25 | 12256.75 |
0.25 | ng/well | 1349.75 | 2572.75 |
0.025 | ng/well | 459.50 | 534.75 |
0.0025 | ng/well | 310.75 | 471.75 |
TABLE 5 |
Formulations and MFI |
Method | |||||
Formulation | Lipid/RNA | Mean size | of formu- | ||
# | Lipid | wt/wt | (nm) | lation | MFI |
Untreated | N/A | N/A | N/A | N/A | 674.67 |
Control | |||||
NPA-002 | DLin-KC2- | 15 | 140 nm | MI | 10318.25 |
DMA | PDI: 0.11 | ||||
NPA-002-2 | DLin-KC2- | 15 | 105 nm | SP | 37054.75 |
DMA | PDI: 0.04 | ||||
NPA-003 | DLin-KC2- | 20 | 114 nm | MI | 22037.5 |
DMA | PDI: 0.08 | ||||
NPA-003-2 | DLin-KC2- | 20 | 95 nm | SP | 37868.75 |
DMA | PDI: 0.02 | ||||
NPA-005 | 98N12-5 | 15 | 127 nm | MI | 11504.75 |
PDI: 0.12 | |||||
NPA-005-2 | 98N12-5 | 15 | 106 nm | SP | 9343.75 |
PDI: 0.07 | |||||
NPA-006 | 98N12-5 | 20 | 126 nm | MI | 11182.25 |
PDI: 0.08 | |||||
NPA-006-2 | 98N12-5 | 20 | 93 nm | SP | 5167 |
PDI: 0.08 | |||||
TABLE 6 |
Formulations |
Formulation # | Lipid | Lipid/RNA wt/wt | Mean size (nm) |
NPA-001 | DLin-KC2- |
10 | 155 nm |
PDI: 0.08 | |||
NPA-002 | DLin-KC2- |
15 | 140 nm |
PDI: 0.11 | |||
NPA-002-2 | DLin-KC2- |
15 | 105 nm |
PDI: 0.04 | |||
NPA-003 | DLin-KC2- |
20 | 114 nm |
PDI: 0.08 | |||
NPA-003-2 | DLin-KC2- |
20 | 95 nm |
PDI: 0.02 | |||
NPA-005 | 98N12-5 | 15 | 127 nm |
PDI: 0.12 | |||
NPA-006 | 98N12-5 | 20 | 126 nm |
PDI: 0.08 | |||
NPA-007 | DLin- |
15 | 148 nm |
PDI: 0.09 | |||
NPA-008 | DLin-K- |
15 | 121 nm |
PDI: 0.08 | |||
NPA-009 | C12-200 | 15 | 138 nm |
PDI: 0.15 | |||
NPA-010 | DLin-MC3- |
15 | 126 nm |
PDI: 0.09 | |||
NPA-012 | DLin- |
20 | 86 nm |
PDI: 0.08 | |||
NPA-013 | DLin-K- |
20 | 104 nm |
PDI: 0.03 | |||
NPA-014 | C12-200 | 20 | 101 nm |
PDI: 0.06 | |||
NPA-015 | DLin-MC3- |
20 | 109 nm |
PDI: 0.07 | |||
TABLE 7 |
Split dose study |
Avg. | Polypeptide | Dose | ||||
Dose of | Total | pmol/mL | per unit drug | Splitting | ||
Group | Treatment | mmRNA | Dose | human EPO | (pmol/ug) | |
1 | |
1 × 100 | |
100 ug | 14.3 | .14 | 1 |
2 | |
3 × 100 | |
300 ug | 82.5 | .28 | 2 |
3 | |
6 × 100 | ug | 600 ug | 273.0 | .46 | 3.3 |
4 | |
3 × 33.3 | ug | 100 ug | 104.7 | 1.1 | 7.9 |
5 | |
6 × 16.5 | ug | 100 ug | 127.9 | 1.3 | 9.3 |
6 | |
6 × 100 | ug | 600 |
0 | — | — |
7 | Buffer Alone | — | — | 0 | — | — |
TABLE 8 |
Dosing Chart |
Total | Dosing | |||||
Group | Treatment | Route | Dose of | Dose | Vehicle | |
1 | Lipoplex-human EPO mmRNA | I.M. | 4 × 100 ug + 30 |
4 × 70 | Lipoplex | |
2 | Lipoplex-human EPO mmRNA | I.M. | 4 × 100 |
4 × 70 | Buffer | |
3 | Lipoplex-human EPO mmRNA | S.C. | 4 × 100 ug + 30 |
4 × 70 | Lipoplex | |
4 | Lipoplex-human EPO mmRNA | S.C. | 4 × 100 |
4 × 70 | Buffer | |
5 | Lipoplex-human EPO mmRNA | I.V. | 200 ug + 30% Lipoplex | 140 | Lipoplex | |
6 | Lipoplexed-Luciferase mmRNA | I.M. | 100 ug + 30 |
4 × 70 ul | Lipoplex | |
7 | Lipoplexed-Luciferase mmRNA | I.M. | 100 |
4 × 70 | Buffer | |
8 | Lipoplexed-Luciferase mmRNA | S.C. | 100 ug + 30 |
4 × 70 ul | Lipoplex | |
9 | Lipoplexed-Luciferase mmRNA | S.C. | 100 |
4 × 70 | Buffer | |
10 | Lipoplexed-human EPO mmRNA | I.V. | 200 ug + 30% Lipoplex | 140 ul | Lipoplex | |
11 | Formulation Buffer | I.M. | 4× |
4 × 70 ul | Buffer | |
TABLE 9 |
Rat Study |
Avg. | Geometric- | |||||||||
Group | Dose | R#1 | R#2 | R#3 | R#4 | R#5 | |
pg/ml | mean pg/ml | |
h- | G# | 1 | 150 μg | 61.8 | 86.3 | 69.9 | 55.2 | 59 | 74.2 | 67.7 | 67.1 |
h- | G# | 2 | 100 μg | 69.4 | 77.8 | 48.2 | 17.6 | 101.9 | 161.5 | 79.4 | 66.9 |
h- | G# | 3 | 50 μg | 143.6 | 60.9 | 173.4 | 145.9 | 61.5 | 23.9 | 101.5 | 85.4 |
h- | G# | 4 | 10 μg | 7.8 | 11.8 | 30.9 | 36.2 | 40.6 | 150.3 | 46.3 | 31.2 |
h- | G# | 5 | 1 μg | 9.1 | 35.8 | — | 46.2 | 18.1 | 34.1 | 28.7 | 25.4 |
| G# | 6 | 100 μg | 34.1 | 36.5 | 13.5 | 13.7 | — | — | 24.5 | 22.4 |
F. Buffer | G#7 | — | 14.7 | 18.5 | 21.2 | 20.3 | — | — | 18.7 | 18.5 | |
TABLE 10 |
Mouse Study |
Average Level | |||||
Route | Treatment | Group | Dose | in serum pg/ml | |
IM | h- |
1 | 100 μg | 96.2 | ||
IM | h- |
2 | 50 μg | 63.5 | ||
IM | h- |
3 | 25 μg | 18.7 | ||
IM | h- |
4 | 10 μg | 25.9 | ||
IM | h- |
5 | 1 μg | 2.6 | ||
| Luc | 6 | 100 |
0 | ||
IM | F. Buffer | 7 | — | 1.0 | ||
SC | h- |
1 | 100 μg | 72.0 | ||
| Luc | 2 | 100 μg | 26.7 | ||
| F. Buffer | 3 | — | 17.4 | ||
TABLE 11 |
Dosing Chart |
Avg. | Geometric- | ||||||||||
Group | Dose | R#1 | R#2 | R#3 | R#4 | R#5 | R#6 | R#7 | pg/ml | mean pg/ml | |
h- |
2 |
100 μg | 60.0 | 62.4 | 53.6 | 33.2 | 68.6 | 66.4 | 72.8 | 59.6 | 58.2 |
h- |
6 |
100 μg | 66.4 | 102.5 | 45.6 | 78.1 | 56.8 | 122.5 | 8.1 | 68.6 | 55.8 |
h-EPO | 12 |
100 μg | 132.9 | 55.1 | 89.0 | 80.1 | 85.6 | 105.6 | 63.3 | 87.4 | 84.5 |
h- |
24 |
100 μg | 51.1 | 76.3 | 264.3 | 142.4 | 77.6 | 73.5 | 75.0 | 108.6 | 95.3 |
h-EPO | 48 |
100 μg | 96.3 | 59.0 | 85.7 | 82.6 | 63.5 | 80.3 | — | 77.9 | 77.0 |
h-EPO | 72 |
100 μg | 46.3 | 66.9 | 73.5 | 57.3 | 136.7 | 110 | 69.7 | 80.1 | 75.8 |
|
24, 48 | 100 μg | 60.2 | 38.5 | 48.8 | 46.1 | 3.6 | 26.1 | — | 37.2 | 29.2 |
and 72 | |||||||||||
| |||||||||||
F. Buffer | |||||||||||
24, 48 | — | 50.0 | 10.0 | 80.9 | 54.7 | — | — | — | 48.9 | 10.4 | |
and 72 | |||||||||||
hour | |||||||||||
TABLE 12 |
VEGF-A Dosing and |
6 hours | 12 |
24 hours | 48 hours | |
Dose (ng) | (pg/ml) | (pg/ml) | (pg/ml) | (pg/ml) |
VEGF-A Dose Containing Natural NTPs |
46.875 | 10.37 | 18.07 | 33.90 | 67.02 |
93.75 | 9.79 | 20.54 | 41.95 | 65.75 |
187.5 | 14.07 | 24.56 | 45.25 | 64.39 |
375 | 19.16 | 37.53 | 53.61 | 88.28 |
750 | 21.51 | 38.90 | 51.44 | 61.79 |
1500 | 36.11 | 61.90 | 76.70 | 86.54 |
VEGF-A Dose Containing Pseudo-U/5mC |
46.875 | 10.13 | 16.67 | 33.99 | 72.88 |
93.75 | 11.00 | 20.00 | 46.47 | 145.61 |
187.5 | 16.04 | 34.07 | 83.00 | 120.77 |
375 | 69.15 | 188.10 | 448.50 | 392.44 |
750 | 133.95 | 304.30 | 524.02 | 526.58 |
1500 | 198.96 | 345.65 | 426.97 | 505.41 |
VEGF-A Dose Containing N1-methyl-Pseudo-U/5mC |
46.875 | 0.03 | 6.02 | 27.65 | 100.42 |
93.75 | 12.37 | 46.38 | 121.23 | 167.56 |
187.5 | 104.55 | 365.71 | 1025.41 | 1056.91 |
375 | 605.89 | 1201.23 | 1653.63 | 1889.23 |
750 | 445.41 | 1036.45 | 1522.86 | 1954.81 |
1500 | 261.61 | 714.68 | 1053.12 | 1513.39 |
TABLE 13 |
Dosing Regimen |
Dose | Dose Vol. | Dosing | Neutrophil | ||||
Gr. | Treatment | Route | N= | (μg/mouse) | (μl/mouse) | Vehicle | Thous/uL |
1 | G-CSF (Gen1) | I.M | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 840* |
2 | G-CSF (Gen1) | S.C | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 430 |
3 | G-CSF (Gen2) | I.M | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 746* |
4 | G-CSF (Gen2) | S.C | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 683 |
5 | Luc (Gen1) | I.M. | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 201 |
6 | Luc (Gen1) | S.C. | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 307 |
7 | Luc (Gen2) | I.M | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 336 |
8 | Luc (Gen2) | S.C | 5 | 2 × 50 ug (four doses) | 50 | F. buffer | 357 |
9 | F. Buffer | I.M | 4 | 0 (four doses) | 50 | F. buffer | 245 |
10 | F. Buffer | S.C. | 4 | 0 (four doses) | 50 | F. buffer | 509 |
11 | Untreated | — | 4 | — | 312 | ||
TABLE 14 |
Dosing Regimen |
Dose | |||||
Vol. | Dosing | Neutrophil | |||
Gr. | Treatment | N= | (μl/mouse) | Vehicle | K/uL |
1 | G-CSF (Gen1) | 5 | 100 | 10% lipoplex | 2.91 |
|
|||||
2 | G-CSF (Gen1) | 5 | 100 | 10% lipoplex | 5.32* |
|
|||||
3 | G-CSF (Gen1) | 5 | 100 | 10% lipoplex | 2.06 |
|
|||||
4 | G-CSF (no | 5 | 100 | 10% lipoplex | 1.88 |
modification) | |||||
|
|||||
5 | G-CSF (no | 5 | 100 | 10% lipoplex | 1.95 |
modification) | |||||
|
|||||
6 | G-CSF (no | 5 | 100 | 10% lipoplex | 2.09 |
modification) | |||||
|
|||||
7 | |
5 | 100 | 10% lipoplex | 2.90 |
|
|||||
8 | |
5 | 100 | 10% lipoplex | 1.68 |
|
|||||
9 | |
4 | 100 | 10% lipoplex | 1.72 |
|
|||||
10 | |
4 | 100 | 10% lipoplex | 2.51 |
|
|||||
11 | |
4 | 100 | 10% lipoplex | 1.31 |
|
|||||
12 | |
4 | 100 | 10% lipoplex | 1.92 |
|
|||||
TABLE 15 |
Dosing Regimen |
Dose Vol. | Dosing | Average Protein | |||
Group | Treatment | N= | (μl/mouse) | Vehicle | Product pg/mL, serum |
G-CSF | G- |
5 | 50 | Saline | 19.8 | |
G- | Luciferase | 5 | 50 | Saline | 0.5 | |
G- | F. buffer | 5 | 50 | F. buffer | 0.5 | |
| EPO | 5 | 50 | Saline | 191.5 | |
EPO | Luciferase | 5 | 50 | Saline | 15.0 | |
EPO | F. buffer | F. buffer | 4.8 | |||
TABLE 16 |
Multi-dose study |
Avg. Pg/mL | |||||
Dose of | Total | human EPO, | |||
Group | Treatment | | Dose | serum | |
1 | |
1 × 100 |
100 ug | 143 |
mmRNA | ||||
2 | |
6 × 100 ug | 600 ug | 256 |
mmRNA | ||||
3 | G- |
1 × 100 |
100 ug | 43 |
4 | G- |
6 × 100 ug | 600 ug | 58 |
5 | Buffer Alone | — | — | 20 |
TABLE 17 |
Signal Peptide Exchange |
293A | MM | RM | ||
Signal peptides | (pg/ml) | (pg/ml) | (pg/ml) | |
G-CSF Natural | 9650 | 3450 | 6050 | |
α-1-anti trypsin | 9950 | 5000 | 8475 | |
Factor IX | 11675 | 6175 | 11675 | |
Prolactin | 7875 | 1525 | 9800 | |
Albumin | 122050 | 81050 | 173300 | |
|
0 | 0 | 0 | |
TABLE 18 |
G-CSF Signal |
G-CSF signal - 2 Donor Average |
pg/ |
2 |
4 |
8 |
20 Hr | 44 Hr |
G-CSF (5mC/pseudouridine) | 120.3 | 136.8 | 421.0 | 346.1 | 431.8 |
G-CSF (5mC/N1-methyl- | 256.3 | 273.7 | 919.3 | 1603.3 | 1843.3 |
pseudouridine) | |||||
G-CSF(Natural-no modification) | 63.5 | 92.6 | 129.6 | 258.3 | 242.4 |
Luciferase (5mC/pseudouridine) | 4.5 | 153.7 | 33.0 | 186.5 | 58.0 |
TABLE 19 |
IFN-alpha signal |
IFN-alpha signal - 2 donor average |
pg/ |
2 |
4 |
8 |
20 Hr | 44 Hr |
G-CSF (5mC/pseudouridine) | 21.1 | 2.9 | 3.7 | 22.7 | 4.3 |
G-CSF (5mC/N1-methyl- | 0.5 | 0.4 | 3.0 | 2.3 | 2.1 |
pseudouridine) | |||||
G-CSF(Natural) | 0.0 | 2.1 | 23.3 | 74.9 | 119.7 |
Luciferase (5mC/pseudouridine) | 0.4 | 0.4 | 4.7 | 1.0 | 2.4 |
R-848 | 39.1 | 151.3 | 278.4 | 362.2 | 208.1 |
Lipofectamine 2000 control | 0.8 | 17.2 | 16.5 | 0.7 | 3.1 |
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US13/897,362 US20130245103A1 (en) | 2011-03-31 | 2013-05-18 | Modified polynucleotides for the production of factor ix |
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US9950068B2 (en) | 2018-04-24 |
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AU2012236099A1 (en) | 2013-10-03 |
US10898574B2 (en) | 2021-01-26 |
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JP7395526B2 (en) | 2023-12-11 |
US20130245103A1 (en) | 2013-09-19 |
US20150017211A1 (en) | 2015-01-15 |
JP5981615B2 (en) | 2016-08-31 |
CA2831613A1 (en) | 2012-10-04 |
JP2015227364A (en) | 2015-12-17 |
WO2012135805A2 (en) | 2012-10-04 |
WO2012135805A3 (en) | 2013-03-14 |
JP2024023436A (en) | 2024-02-21 |
JP2014511687A (en) | 2014-05-19 |
JP2021075578A (en) | 2021-05-20 |
US20210386857A1 (en) | 2021-12-16 |
AU2019240643A1 (en) | 2019-10-24 |
AU2022201745A1 (en) | 2022-04-07 |
US20170258915A1 (en) | 2017-09-14 |
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