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  1. Erweiterte Patentsuche
VeröffentlichungsnummerUS9675796 B2
PublikationstypErteilung
AnmeldenummerUS 14/536,924
Veröffentlichungsdatum13. Juni 2017
Eingetragen10. Nov. 2014
Prioritätsdatum10. Nov. 2013
Auch veröffentlicht unterEP2878335A2, EP2878335A3, US20150133956
Veröffentlichungsnummer14536924, 536924, US 9675796 B2, US 9675796B2, US-B2-9675796, US9675796 B2, US9675796B2
ErfinderAvinoam Dayan, Israel Dvorsky, Hernan Altman
Ursprünglich BevollmächtigterBrainsgate Ltd.
Zitat exportierenBiBTeX, EndNote, RefMan
Externe Links: USPTO, USPTO-Zuordnung, Espacenet
Implant and delivery system for neural stimulator
US 9675796 B2
Zusammenfassung
Apparatus is described, the apparatus including an oral surgical guide. The oral surgical guide includes an arch portion configured to be placed on a dental arch of a subject; and an extension portion extending from the arch portion, and shaped to define a guide hole. Other applications are also described.
Bilder(20)
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Ansprüche(7)
The invention claimed is:
1. A method comprising:
using an oral surgical guide generated using CT scan data and comprising (a) an arch portion configured to be placed on a dental arch of a subject, and (b) an extension portion extending from the arch portion, and shaped to define a guide hole to determine (i) a location of a greater palatine foramen of a palate of an oral cavity of the subject, and (ii) a suitable angle for entering a greater palatine canal;
inserting a steerable implantable neural stimulator at the suitable angle into the greater palatine foramen of the subject, through the hole in the surgical guide; and
advancing the stimulator through the greater palatine canal of the subject to a sphenopalatine ganglion (SPG) of the subject.
2. The method according to claim 1, wherein the oral surgical guide is generated using intra-oral scan data and the CT scan data.
3. The method according to claim 1, further comprising creating an opening in mucosa of the subject using the stimulator, wherein inserting the stimulator comprises inserting the stimulator through the opening.
4. The method according to claim 3, further comprising coupling a tool, in which the stimulator is disposed, to the hole in the surgical guide, and wherein creating the opening comprises creating the opening while the tool is coupled to the hole in the surgical guide.
5. The method according to claim 1, wherein inserting the stimulator comprises inserting the stimulator using a tool, and wherein the method further comprises, following the advancing of the stimulator, allowing the tool to be withdrawn from the greater palatine canal without dislodging the stimulator by disengaging a locking element of the stimulator from the tool.
6. The method according to claim 5, wherein the locking element is shaped as a ball, and wherein disengaging the locking element comprises disengaging the ball-shaped locking element from the tool.
7. A method comprising:
using an oral surgical guide generated using CT scan data to determine (i) a location of a greater palatine foramen of a palate of an oral cavity of a subject, and (ii) a suitable angle for entering a greater palatine canal;
inserting a steerable implantable neural stimulator at the suitable angle into the greater palatine foramen of the subject, through a hole in the surgical guide; and
advancing the stimulator through the greater palatine canal of the subject to a sphenopalatine ganglion (SPG) of the subject,
wherein inserting the stimulator comprises inserting the stimulator using a tool, and wherein the method further comprises, following the advancing of the stimulator, allowing the tool to be withdrawn from the greater palatine canal without dislodging the stimulator, by disengaging a locking element of the stimulator from the tool, and
wherein the locking element is shaped as a ball, and wherein disengaging the locking element comprises disengaging the ball-shaped locking element from the tool.
Beschreibung
CROSS-REFERENCES TO RELATED APPLICATIONS

The present application claims priority from Israel Patent Application No. 229345 to Dayan et al., entitled “Implant and delivery system for neural stimulator,” filed Nov. 10, 2013, which is incorporated herein by reference.

FIELD OF THE APPLICATION

Some applications of the invention relate generally to medical procedures and implantable devices. More specifically, some applications of the invention relate to the use of electrical devices for implantation in the head.

BACKGROUND

Surgical guides are typically generated based on computed tomography (CT) image data, and provide a dentist with guidance as to an optimal location for drilling into a jaw bone of a subject during implantation of dental implants.

U.S. Pat. No. 7,120,489 to Shalev and Gross, which is assigned to the assignee of the present patent application and is incorporated herein by reference, describes apparatus for modifying a property of a brain of a patient, including electrodes applied to a sphenopalatine ganglion (SPG) or a neural tract originating in or leading to the SPG. A control unit drives the electrodes to apply a current capable of inducing (a) an increase in permeability of a blood-brain barrier (BBB) of the patient, (b) a change in cerebral blood flow of the patient, and/or (c) an inhibition of parasympathetic activity of the SPG.

U.S. Pat. No. 7,117,033 to Shalev et al., describes a method for treating a subject, comprising positioning at least one electrode at least one site of the subject for less than about 3 hours, applying an electrical current to the site of the subject, and configuring the current to increase cerebral blood flow (CBF) of the subject, so as to treat a condition of the subject. The site is selected from the list consisting of: a sphenopalatine ganglion (SPG) of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, an infraorbital nerve of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.

U.S. Pat. No. 7,561,919 to Shalev et al., describes apparatus for application to a subject, including an elongated support element having a length of between 1.8 cm and 4 cm, and having proximal and distal ends; and one or more electrodes fixed to the support element in a vicinity of the distal end thereof, and adapted to apply an electrical current to a sphenopalatine ganglion (SPG) of the subject. The apparatus further includes a receiver, fixed to the support element, and electrically coupled to the electrodes; and a wireless transmitter, adapted to be placed in an oral cavity of the subject, and to be wirelessly coupled to the receiver. Other embodiments are also described.

SUMMARY OF APPLICATIONS

In some applications, a system is provided for delivery of a neural stimulator implant for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject. Stimulation of the SPG typically treats various acute brain hypoperfusion states, such as occur during acute ischemic stroke. Typically, the system includes apparatus comprising an implantable neural stimulator, a steerable delivery guide, and an oral surgical guide.

The neural stimulator implant is configured to be passed through a greater palatine foramen of a palate of an oral cavity of a subject into a greater palatine canal, such that the neural stimulator implant is brought into a vicinity of a sphenopalatine ganglion (SPG), for example, into contact with the SPG. For some applications, the implant is a flexible implant configured to conform to the anatomical structure of the greater palatine canal, to facilitate advancement therethrough. For some applications, the implant comprises at least one electrode for stimulation of the SPG.

The neural stimulator implant is typically coupled to the steerable delivery guide. For some applications, a distal end of the steerable delivery guide is configured to puncture oral mucosa of the subject, allowing the neural stimulator implant to be passed through the palate in a minimally-invasive procedure, without requiring a prior surgical incision in the mucosa. Typically, the distal end of the steerable delivery guide is also configured to be passed through the greater palatine foramen into the greater palatine canal. The delivery guide is steered in the canal in order to deliver the neural stimulator implant to the SPG.

Typically, the surgical guide is generated based on CT data obtained by imaging the subject. Based on the CT data, the surgical guide is formed to provide a guide hole for locating the entrance to the greater palatine canal, such that the implantable neural stimulator may be passed through the guide hole and then into the greater palatine canal. In particular, the surgical guide is typically configured for placement on the subject's dental arch, such that an extension portion of the surgical guide extending away from the dental arch contacts the roof of the oral cavity of the subject, and the guide hole is thereby automatically placed over the entrance to the greater palatine foramen of the subject.

For some applications, the surgical guide is generated based on data from both a CT scan and an intra-oral scan. For such applications, an intra-oral scan of the upper palate, teeth, and/or gums of the subject is performed in addition to the CT scan, and the data from both scans are registered for preparation of the surgical guide. Alternatively, the surgical guide is initially generated based on data from an intra-oral scan only, and subsequently CT data are used for preparing the guide hole in the surgical guide.

Thus, in accordance with some applications of the present invention, the surgical guide is configured to guide an operating physician to the location of the greater palatine foramen of the subject, to facilitate advancement of the neural stimulator implant therethrough by injecting the implant into the canal. Additionally, the guide hole in the surgical guide facilitates penetration of the mucosa at an appropriate angle for entrance into the greater palatine foramen at an angle suitable for advancement of the neural stimulator implant through the canal. Further additionally, the CT data in combination with the surgical guide provides the operating physician with information regarding the anatomical structure of the greater palatine canal, thereby facilitating navigation and advancement of the implantable neural stimulator coupled to the steerable delivery guide through the canal. Thus, in accordance with some applications, the surgical guide in combination with the CT data, guides the passing through oral mucosa of the subject and navigation of the neural stimulator implant within a complex anatomical structure. Additionally, but not necessarily, the surgical guide provides guidance for drilling at a predetermined depth into the jaw bone.

The surgical guide typically allows for use of the neural stimulator implant by facilitating precise and safe implant deployment at the SPG, even by a less-skilled surgeon. Similarly, in general, the surgical guide allows a less-skilled surgeon to access the SPG in a safe and precise manner (even in the absence of implanting a neural stimulator implant).

For some applications, the delivery guide is configured to facilitate delivery of the neural stimulator to the SPG site without the need for the physician to consider a navigation map of the greater palatine canal. For some such applications, CT data regarding the anatomical structure of the greater palatine canal is used to create (typically by 3D printing) a curved guide groove surface on a portion of the delivery guide. When the neural stimulator is mounted on a distal end of the delivery guide, it is advanced distally in the canal by advancement of a slide-bar of the delivery guide. At the same time, a guiding pin which is disposed within the curved guide groove is advanced within the groove, causing rotation of the slide-bar with respect to the delivery guide, thereby steering the neural stimulator in the greater palatine canal.

There is therefore provided, in accordance with an application of the present invention, apparatus, including:

an oral surgical guide including:

    • an arch portion configured to be placed on a dental arch of a subject; and
    • an extension portion extending from the arch portion, and shaped to define a guide hole.

For some applications, the extension portion extends from the arch portion in a superior and lingual direction with respect to the arch.

For some applications, the apparatus includes:

a steerable implantable neural stimulator configured to apply electrical stimulation to a sphenopalatine ganglion (SPG) of the subject,

the guide hole is configured to guide the stimulator through a greater palatine foramen of a palate of an oral cavity of the subject and into a greater palatine canal of the subject.

For some applications, the guide hole is configured to guide the stimulator through the greater palatine foramen at an angle that is suitable for entering the greater palatine canal.

For some applications, the surgical guide is generated by using CT scan data of the subject and intra-oral scan data of the subject, and the guide hole corresponds to a location of a greater palatine foramen of the subject.

For some applications, a portion of the surgical guide corresponding to a surface of gum tissue of the subject is shaped in a curved manner that matches curvature of the gum tissue.

For some applications, the surgical guide is generated by using CT scan data of the subject and not using intra-oral scan data of the subject, and the guide hole corresponds to a location of a greater palatine foramen of the subject.

For some applications, the implant is shaped to define proximal and distal portions, and the distal portion of the implant is configured to puncture oral mucosa of the subject.

For some applications, the implant is shaped to define proximal and distal portions, and the distal portion of the implant includes at least one electrode configured to apply electrical stimulation to a sphenopalatine ganglion (SPG) of the subject.

For some applications, the surgical guide is formed by a three-dimensional printing process.

For some applications, the surgical guide is shaped by shaping a pliable material on the dental arch of the subject.

For some applications, the pliable material includes a thermoplastic material.

There is further provided, in accordance with an application of the present invention, a method including:

using an oral surgical guide generated using CT data to determine a location of a greater palatine foramen of a palate of an oral cavity of a subject;

inserting a steerable implantable neural stimulator into the greater palatine foramen of the subject, through a hole in the surgical guide; and

advancing the stimulator through a greater palatine canal of the subject to a sphenopalatine ganglion (SPG) of the subject.

For some applications, using the oral surgical guide generated using CT data further includes using the oral surgical guide to determine a suitable angle for entering of the greater palatine canal, and inserting the stimulator into the greater palatine foramen includes inserting the stimulator at the suitable angle.

For some applications, the method includes creating an opening in mucosa of the subject using the stimulator, and inserting the stimulator includes stimulator through the opening.

For some applications, the method includes coupling a tool, in which the stimulator is disposed, to the hole in the surgical guide, and creating the opening includes creating the opening while the tool is coupled to the hole in the surgical guide.

For some applications, inserting the stimulator includes inserting the stimulator using a tool, and the method further includes, following the advancing of the stimulator, allowing the tool to be withdrawn from the greater palatine canal without dislodging the stimulator by disengaging a locking element of the stimulator from the tool.

For some applications, the locking element is shaped as a ball, and disengaging the locking element includes disengaging the ball-shaped locking element from the tool.

There is further provided, in accordance with an application of the present invention, apparatus for use with a tool, the apparatus including:

an oral surgical guide including:

    • an arch portion configured to be placed on a dental arch of a subject; and
    • an extension portion from the arch portion, and shaped to define (a) a guide hole, and (b) a protruding portion including a first coupling element configured to lockingly couple to the tool.
      For some applications, the protruding portion is shaped to define a screw thread.

There is further provided, in accordance with an application of the present invention, a method including:

using a processor, receiving CT data of an oral cavity of a subject acquired while (a) a surgical guide and (b) one or more markers, were in the oral cavity;

using the processor, identifying a position of one or more markers on a drill with respect to respective sites on the surgical guide corresponding to the markers in the oral cavity; and

using the processor and the identified position, guiding drilling of a hole in the surgical guide, by the drill, at a site on the surgical guide corresponding to a greater palatine foramen of the subject.

For some applications, the one or more markers are on the surgical guide, and receiving the CT data using the processor includes receiving the CT data using the processor, the CT data having been acquired while the surgical guide having the one or more markers thereon was in the oral cavity.

For some applications, the one or more markers in the oral cavity are one or more teeth of the subject.

For some applications, the surgical guide includes a thermoplastic material and guiding drilling of a hole in the surgical guide includes drilling a hole in the thermoplastic material.

There is further provided, in accordance with an application of the present invention, a method, including:

providing a flexible, elongate implant having electrodes thereon and an unconstrained shape having a bend at least at a distal end portion of the implant;

subsequently, advancing the implant through a greater palatine canal of a subject; and

utilizing the bend at the distal end portion of the implant to facilitate steering of the implant during the advancing of the implant.

For some applications, the implant includes a nitinol portion which provides the bend, and providing the implant includes providing the implant having the nitinol portion.

For some applications, the method includes, following the advancing of the implant, leaving the implant in the greater palatine canal of the subject while the distal end portion of the implant is constrained and not bent as it was prior to the advancing of the implant.

There is further provided, in accordance with an application of the present invention, apparatus, including:

a flexible, elongate implant, the implant having an unconstrained shape having a bend at least at a distal end portion of the implant, the implant including:

    • two or more electrodes;
    • a flexible portion disposed at least between the two electrodes; and
    • a receiving coil configured to receive energy for powering driving of the electrodes.

There is further provided, in accordance with an application of the present invention, apparatus including:

an elongated implantable neural stimulator having proximal and distal sites and configured to apply electrical stimulation to a sphenopalatine ganglion (SPG) of a subject; and

electronic circuitry having first and second portions and coupled respectively to the proximal and distal sites of the implantable neural stimulator, the electronic circuitry in the first portion being flexibly coupled to the electronic circuitry in the second portion.

For some applications, the apparatus includes a flexible connecting element coupled to the first and second portions of the electronic circuitry.

There is further provided, in accordance with an application of the present invention, apparatus for delivery of an implantable neural stimulator to a sphenopalatine ganglion (SPG) of a subject, including:

a tool having a distal portion coupled to the implantable neural stimulator and a proximal portion; and

a slide-bar at the proximal portion of the tool, the slide-bar including a distal portion and a proximal portion, the proximal portion of the slide-bar being coupled to the stimulator such that distal advancement of the proximal portion of the slide-bar produces distal advancement of the stimulator, the proximal and distal portions of the slide-bar each including a respective magnetic element, the magnetic elements being configured to couple the proximal and distal portions of the slide-bar to each other unless a distally-directed force applied to the distal portion of the slide-bar exceeds a threshold.

There is yet further provided, in accordance with an application of the present invention, a method including:

using an oral surgical guide generated using scan data selected from the group consisting of: intra-oral scan data and CT scan data, to determine a location of a greater palatine foramen of a palate of an oral cavity of a subject;

inserting a steerable implantable neural stimulator into the greater palatine foramen of the subject, through a hole in the surgical guide; and

advancing the stimulator through a greater palatine canal of the subject to a sphenopalatine ganglion (SPG) of the subject.

For some applications, using scan data selected from the group consisting of intra-oral scan data and CT scan data, includes using CT scan data and not intra-oral scan data.

For some applications, using scan data selected from the group consisting of intra-oral scan data and CT scan data, includes using intra-oral scan data and not CT scan data.

For some applications, using scan data selected from the group consisting of intra-oral scan data and CT scan data, includes using intra-oral scan data and CT scan data.

For some applications, using the oral surgical guide generated using the scan data includes using the oral surgical guide generated using the CT scan data, and using the oral surgical guide generated using the CT scan data further includes using the oral surgical guide to determine a suitable angle for entering of the greater palatine canal, and inserting the stimulator into the greater palatine foramen includes inserting the stimulator at the suitable angle.

For some applications, the method includes creating an opening in mucosa of the subject using the stimulator, inserting the stimulator includes inserting the stimulator through the opening.

For some applications, the method includes coupling a tool, in which the stimulator is disposed, to the hole in the surgical guide, and creating the opening includes creating the opening while the tool is coupled to the hole in the surgical guide.

For some applications, inserting the stimulator includes inserting the stimulator using a tool, and the method further includes, following the advancing of the stimulator, allowing the tool to be withdrawn from the greater palatine canal without dislodging the stimulator by disengaging a locking element of the stimulator from the tool.

For some applications, the locking element is shaped as a ball, and disengaging the locking element includes disengaging the ball-shaped locking element from the tool.

There is yet further provided, in accordance with an application of the present invention, a method including:

receiving CT scan data and intra-oral scan data of a subject; and

using the CT and intra-oral scan data, generating an oral surgical guide shaped to define a hole, the hole being placeable against a location of a greater palatine foramen of the subject.

For some applications, generating the oral surgical guide includes:

generating the oral surgical guide without the hole, using the intra-oral scan data;

subsequently, performing the step of receiving the CT scan data; and

subsequently, generating the oral surgical guide with the hole by creating the hole using the CT scan data.

There is yet further provided, in accordance with an application of the present invention, apparatus for delivery of an implant to an anatomical site of a subject, the apparatus including:

a delivery tool having a proximal portion, and having a distal portion that is coupled to the implant;

a surface at the proximal portion, the surface shaped to define a curved guide groove based on data obtained by imaging the anatomical site of the subject;

a slide-bar slidably coupled to the proximal portion; and

a guiding pin disposed within the curved guide groove and configured such that distal advancement of the slide-bar with respect to the proximal portion produces (1) relative motion of the guiding pin with respect to the curved guide groove, and (2) rotation of the slide-bar with respect to a longitudinal axis of the delivery tool.

For some applications, the surface shaped to define the curved guide groove is a surface of the delivery tool, and the guiding pin is fixedly coupled to the slide-bar.

For some applications, the surface shaped to define the curved guide groove is a surface of the slide-bar, and the guiding pin is fixedly coupled to the delivery tool.

There is still provided, in accordance with an application of the present invention, a system including:

a CT scanning device configured to image a subject;

an intra-oral scanning device configured to image the subject; and

a three-dimensional printing device configured to generate, based on the CT and intra-oral scanning of the subject, a surgical guide that is shaped to define a guide hole for locating a greater palatine foramen of a palate of an oral cavity of the subject.

The present invention will be more fully understood from the following detailed description of embodiments thereof, taken together with the drawings, in which:

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a system for delivery of a neural stimulator implant for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention;

FIG. 2 is a schematic illustration of a delivery guide being advanced through a guide hole of an oral surgical guide, in accordance with some applications of the present invention;

FIGS. 3A-C are schematic illustrations of the surgical guide shaped to define a guide hole for locating the entrance to the greater palatine canal, in accordance with some applications of the present invention;

FIGS. 4A-D are schematic illustrations of the system for delivery of a neural stimulator implant for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention;

FIG. 5 is a schematic illustration of the neural stimulator implant for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention;

FIG. 6 is a schematic illustration of a tool for facilitating delivery of a neural stimulator implant for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention;

FIG. 7 is a schematic illustration of a tool for facilitating delivery of a neural stimulator implant for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention;

FIG. 8 is a schematic illustration of a neural stimulator implant mounted onto a tool for facilitating delivery thereof for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention;

FIGS. 9A-B are schematic illustrations of the neural stimulator implant, in accordance with some applications of the present invention;

FIG. 10 is a schematic illustration of the neural stimulator implant, in accordance with some applications of the present invention;

FIG. 11 is a schematic illustration of the neural stimulator implant having a bent distal end, in accordance with some applications of the present invention;

FIGS. 12A-C are schematic illustrations of a tool comprising a guiding groove for facilitating delivery of a neural stimulator implant for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention; and

FIG. 13 is a block diagram showing steps for preparation of a surgical guide, in accordance with some applications of the present invention.

DETAILED DESCRIPTION OF APPLICATIONS

Reference is made to FIG. 1, which is a schematic illustration of a system 20 for delivery of a neural stimulator implant 32 for electrical stimulation of a sphenopalatine ganglion (SPG) of a subject, in accordance with some applications of the present invention. Typically, system 20 includes implantable neural stimulator 32, steerable delivery guide 34, and an oral surgical guide 40.

Typically, neural stimulator implant 32 is configured to be passed through a greater palatine foramen of the hard palate of the oral cavity of the subject, into a greater palatine canal, such that the neural stimulator implant is brought into a vicinity of a sphenopalatine ganglion (SPG). For some applications, the implant is an elongated, flexible implant having an unconstrained shape and configured to conform to the anatomical structure of the greater palatine canal, for advancement therethrough. For some applications, the implant comprises at least one electrode, e.g., a wire electrode, for stimulation of the SPG. Typically, implant 32 is shaped to define a curved or bent distal end, which facilitates steering of the implant during the advancing of the implant in the canal. (For the purposes of the specification and claims of the present patent application, the terms “curved” or “bent” with respect to the distal end of the implant are to be understood as interchangeable.) Typically, following the advancing of the implant and deployment thereof in the vicinity of the SPG, for some subjects, the distal end of the implant is constrained and substantially not curved due to the anatomy of the canal, which is generally straight in the vicinity of the SPG in these subjects. For other subjects, the canal is curved in the vicinity of the SPG, and thus the distal end of the implant is curved at its implantation site in the vicinity of the SPG.

For some applications, neural stimulator implant 32 is coupled to steerable delivery guide 34. Implant 32 is configured to be passed through guide 34, such that both implant 32 and guide 34 are advanced through the greater palatine foramen into the greater palatine canal, and implant 32 is brought into a vicinity of a sphenopalatine ganglion (SPG). Steerable delivery guide 34 is retracted after placement of implant 32.

FIG. 1 shows an exploded view of neural stimulator implant 32 passed through delivery guide 34. Delivery guide 34 is typically less flexible than neural stimulator implant 32, and thereby facilitates smooth passage of the implant through the greater palatine canal and proper delivery of implant 32 to the SPG.

For some applications, a distal end 33 of steerable delivery guide 34 is configured to puncture oral mucosa of the subject, allowing neural stimulator implant 32 to be passed through the palate in a minimally-invasive procedure, without requiring a prior surgical incision in the mucosa. Typically, the distal end of the steerable delivery guide is also configured to be passed through the greater palatine foramen into the greater palatine canal. The delivery guide is steered in the canal in order to deliver the neural stimulator implant to the SPG. For some applications, neural stimulator implant 32 is configured to puncture or otherwise create an opening in the oral mucosa of the subject. Following insertion of implant 32 into the mucosa, the surgeon may optionally seal the puncture site by applying pressure to the puncture site in order to facilitate self-healing of the hole, e.g., by keeping a finger on the puncture site.

FIG. 1 additionally shows surgical guide 40 (represented by the dotted structure) placed on teeth 2 of a dental arch 54 of the subject. (It is to be understood that for subjects without teeth, guide 40 is placed on the gums.) Surgical guide 40 is generated based on CT data of the subject and typically serves as a guide for locating the entrance to the greater palatine canal through the greater palatine foramen of the hard palate. Surgical guide 40 comprises an arch portion 59 configured for placement on dental arch 54, and an extension portion 58 (shown in FIGS. 2-3) that extends away from the arch portion. The extension portion is shaped to define a guide hole 6 (shown in FIGS. 2-3), which provides an operating physician with the location and preferred entry angle to the greater palatine foramen. Typically the location and angle of the entrance to the canal, as well as the length of the canal, varies among the population. Therefore, surgical guide 40 allows safe and accurate entry into the canal, and navigation therethrough, in accordance with the subject's anatomy, based on the CT data. Surgical guide 40 additionally inhibits excessive insertion of implant 32 into the canal.

For some applications, a distal end 38 of an angular guide 36 is placed on extension portion 58 of surgical guide 40 to facilitate advancement of delivery guide 34 through guide hole 6 in surgical guide 40. Typically, distal end 38 plugs into hole 6, such that angular guide 36 facilitates advancement of delivery guide 34 into hole 6 at the preferred angle, based on the CT data. When angular guide 36 is locked properly in place with respect to surgical guide 40, delivery guide 34 is released by turning knob 63 in order to allow advancement of guide 34 through guide hole 6. A tool 70 is configured to direct advancement of guide 34 through guide hole 6 and subsequently through the greater palatine foramen into the greater palatine canal. Handle 60 of tool 70 is steered and/or advanced, in order to direct motion of steerable delivery guide 34.

Typically, the passage of implant 32 and delivery guide 34 into the greater palatine canal is facilitated by image-guided surgical techniques, e.g., using optical fiducial markers 50, 51 and 52 on tool 70 (and/or fiducial markers on guide 34). For some applications, an image-guided surgery processor utilizes location data derived from markers 50, 51 and 52, in combination with fiducial markers on the subject (e.g., placed on the teeth, face or a head of the subject) in order to register the pre-operative CT data with the current position of the tool and thereby facilitate steering and advancement of steerable delivery guide 34 through the greater palatine canal. Alternatively or additionally, the image-guided surgery processor utilizes location data derived from markers 50, 51 and 52 in combination with registration data obtained by (a) contacting a tool with a fiducial marker to multiple spots on the subject's head that can also be identified in the pre-operative CT image, and/or (b) visualizing markers 50, 51, and/or 52 when angular guide 36 is locked in place, for example, by plugging distal end 38 into guide hole 6 or by a locking mechanism (as described herein below with reference to FIGS. 4A-C). For some applications, handle 60 comprises a linear and/or an angular encoder configured to facilitate recording of location data indicative of the current position and orientation of neural stimulator implant 32. It is noted that the fiducial markers described herein can be used both in order to identify locations in the subject's anatomy, and also as a reference marker, in order to continually allow the image-guided surgery processor to identify a current position of the subject's head, which can move.

Additionally, slide-bar 57 on tool 70 facilitates advancement of delivery guide 34 distally through guide hole 6. Typically, slide-bar 57 provides steering functionality for facilitating advancement of guide 34 into the greater palatine canal. Bar 57 is typically slidable with respect to handle 60. Advancement of slide-bar 57 with respect to handle 60 advances delivery guide 34 through the greater palatine canal. Additionally or alternatively, marker 50 comprises steering functionality and is rotated around a center thereof in order to steer guide 34 and neural stimulator implant 32 within the canal in order to deliver the neural stimulator implant to the SPG. Further additionally or alternatively, handle 60 is rotated as indicated by arrow 13, in order to advance and orientate steerable delivery guide 34 within the greater palatine canal.

For some applications, additional steering options are employed to allow control of the advancement of implant 32 within the canal. For example, using a joystick allows steering the implant in a left/right and up/down direction, as well as rotation around an axis.

Typically, the greater palatine canal is curved and multiple openings are naturally formed along the greater palatine canal. Therefore, proper steering of guide 34 within the canal generally ensures delivery of guide 34 and neural stimulator implant 32 to the SPG.

For some applications, surgical guide 40 is coupled to or used in association with a second arch portion (not shown). The second arch portion is typically configured for placement on a lower dental arch of the subject. The second arch portion typically stabilizes upper arch portion 59, by pressing portion 59 against the upper teeth and palate. Additionally or alternatively, a stabilizing element 90 is placed between the lower and upper dental arches of the subject, and facilitates the squeezing of arch portion 59 against the upper teeth and palate.

Reference is made to FIG. 2, which is a schematic illustration of steerable delivery guide 34 being steered and advanced through guide hole 6 of surgical guide 40, in accordance with some applications of the present invention. Surgical guide 40 comprises arch portion 59 configured for placement on dental arch 54 and extension portion 58 which is shaped to define guide hole 6. Extension portion 58 contacts the roof of the oral cavity of the subject, and guide hole 6 is thereby automatically placed over the entrance to the greater palatine foramen of the subject.

Thus, in accordance with some applications of the present invention, surgical guide 40 is configured to guide an operating physician to the location of the greater palatine foramen of the subject, to facilitate advancement of guide 34 therethrough. Additionally, guide hole 6 in the surgical guide facilitates penetration of the mucosa at an appropriate angle for entrance into the greater palatine foramen at an angle suitable for advancement of guide 34 through the canal. Further additionally, the CT data in combination with the surgical guide provide the operating physician with information regarding the anatomical structure of the greater palatine canal, thereby facilitating navigation and advancement of implantable neural stimulator 32 coupled to steerable delivery guide 34 through the canal.

FIGS. 3A-B are schematic illustrations of surgical guide 40 comprising arch portion 59 configured for placement on teeth 2 of a subject, or on gums of the subject, in accordance with some applications of the present invention. Extension portion 58 extends, lingually and in a superior direction, away from arch portion 59 and is placed in contact with the roof of the oral cavity of the subject. Extension portion 58 is shaped to define guide hole 6, which is automatically placed over the entrance to the greater palatine foramen when surgical guide 40 is placed on teeth 2, or gums, of the subject. For some applications, an adhesive, e.g., glue, is used to secure guide 40 to the teeth or gums of the subject.

Typically the location of the greater palatine foramen varies among the population. For example, in some subjects the greater palatine foramen is associated with the upper third molar tooth. In other subjects, the greater palatine foramen is associated with the second molar or between the second and third molar. It is noted that the location of guide hole 6 is shown in the figures by way of illustration and not limitation. It is understood that the location of guide hole 6 is set based on the location of the greater palatine foramen of each particular subject. Surgical guide 40 is typically custom-made based on a CT scan of the subject, such that guide hole 6 is placed over the greater palatine foramen of each individual subject, in order to guide the physician to the correct location.

Reference is now made to FIG. 3C. For some applications, surgical guide 40 comprises a second extension portion 58 located contralateral to extension portion 58, for bilateral electrical stimulation of the right and left SPG (e.g., for treatment of vascular dementia).

For some applications, surgical guide 40 is fabricated by three-dimensional (3D) printing.

Alternatively, surgical guide 40 is manufactured by molding a pliable material, such as a thermoplastic sheet, and drilling guide hole 6 with a drill. (After the molding, a suitable process is used to make the pliable material generally rigid, e.g., by heat treatment or ultraviolet curing.)

Typically, the drill has markers (e.g., RF coils, or optical markers) in order to ensure drilling of guide hole 6 in a proper location corresponding to the greater palatine foramen. Typically, prior to drilling of the hole, the unfinished surgical guide is placed on teeth or gums of the subject and CT data of the oral cavity is acquired. Subsequently, the surgical guide is removed from the subject's mouth. Using a processor, the CT data of the oral cavity with the surgical guide is received and is used to determine a desired position of the drill. Directional and orientational guidance for performing the drilling is generated using the one or more markers on the drill. Subsequently, the processor guides drilling of the hole in the surgical guide at a site on the surgical guide which corresponds to the greater palatine foramen of the subject.

Reference is made to FIGS. 4A-C, which are schematic illustrations of dental arch 59, comprising a locking mechanism 94, in accordance with some applications of the present invention. Locking mechanism 94 is configured to lock tool 70 and angular guide 36 in place with respect to surgical guide 40, such that delivery guide 34 and implant 32 are advanced accurately through guide hole 6. Generally, locking mechanism 94 comprises (a) a projecting portion of surgical guide 40 which is typically shaped to provide a screw thread on an outer surface of projection 72, and (b) a screw thread on an inner surface of the locking portion on tool 70. The screw threads on projection 72 and on tool 70 engage each other, thereby locking the projection to the tool.

FIG. 4A shows surgical guide 40 comprising arch portion 59 and extension portion 58. For some applications, extension portion 58 further comprises projection 72, which protrudes away from extension portion 58. Projection 72 is typically shaped to define the screw thread profile described hereinabove, on an outer surface of the protrusion (as shown). (Alternatively, the screw-thread is on the inner surface of the projection.)

Reference is made to FIG. 4B. For some applications, angular guide 36, which is mounted to tool 70, comprises locking portion 46 which is shaped to define a screw thread (described hereinabove), configured to engage projection 72 on surgical guide 40. Locking portion 46 is typically rotated in order to lock locking portion 46 to projection 72, thereby restricting motion of delivery guide 34.

FIG. 4C shows locking mechanism 94 in a locked state thereof. It is to be noted that surgical guide 40 is shaped to define a screw-shaped projection 72 by way of illustration and not limitation. In general, surgical guide 40 may comprise a first coupling, and guide 36 and/or tool 70 may comprise a second coupling. The first coupling may comprise a male coupling while the second coupling may comprise a female coupling, or vice versa.

It is noted that locking mechanism 94 is described by way of illustration and not limitation. For some applications, tool 70 and angular guide 36 are locked in place with respect to surgical guide 40 by plugging distal end 38 into guide hole 6. For example, locking of tool 70 with respect to surgical guide 40 is allowed when angular guide 36 is plugged into guide hole 6 at an appropriate angle and/or a particular orientation (e.g., via a fin extending at 12 o'clock that fits into a corresponding slot on surgical guide 40).

Reference is made to FIG. 5, which is a schematic illustration of an example of neural stimulator implant 32 for electrical stimulation of a sphenopalatine ganglion (SPG) of the subject, in accordance with some applications of the present invention.

Neural stimulator implant 32 is typically 0.5-1.5 mm in diameter, e.g., 1 mm. Thus, advancement of implant 32 typically does not require dilation of the greater palatine canal. Alternatively, placement of implant 32 includes pre-dilation of the greater palatine canal.

For some applications, neural stimulator implant 32 is electrically coupled to circuitry 56 which is adapted to be placed outside the greater palatine canal, e.g., the circuitry may be positioned submucosally in the oral cavity. For other applications, circuitry 56 is adapted for insertion into the oral mucosa of the subject. Following insertion of electronic circuitry 56 into the mucosa, the surgeon may seal the puncture site by applying pressure to the puncture site in order to facilitate self-healing of the hole, e.g., by keeping a finger on the puncture site. Typically, neural stimulator implant 32 itself is configured for puncturing the oral mucosa.

For some applications, electronic circuitry 56 is advanced along an exterior of delivery guide 34 (as shown), until circuitry 56 is inserted into the mucosa.

As shown in FIG. 5, implant 32 typically comprises at least two steering wires 101 configured to facilitate steering of implant 32 within the greater palatine canal. Additionally, implant 32 comprises a stimulation wire 102 coupled to an electrode 106, for electrical stimulation of the sphenopalatine ganglion (SPG) of the subject, once implant 32 is delivered to the vicinity of the SPG.

Typically, the delivery apparatus comprises a pusher 104 disposed within delivery guide 34 (FIG. 1), which is configured to advance implant 32 within the greater palatine canal, e.g., by pushing an inner surface of electrode 106.

Reference is made to FIG. 6, which is a schematic illustration of an implantation tool 700 for facilitating delivery of a neural stimulator implant 320 (described hereinbelow with reference to FIGS. 9A-B and 10) to a sphenopalatine ganglion (SPG) of a subject, for electrical stimulation of the SPG, in accordance with some applications of the present invention.

Tool 700 is typically used in combination with surgical guide 40 (described herein with reference to FIGS. 3A-C) and directs advancement of the neural stimulator implant through guide hole 6 in surgical guide 40 and subsequently through the greater palatine foramen into the greater palatine canal.

Tool 700 typically comprises a handle 600 and a distal tip portion 720. In general, prior to use, the neural stimulator implant is mounted in distal tip portion 720. FIG. 6 shows the implant partially protruding from tip portion 720, as it appears after it has been initially advanced into the greater palatine canal. (For clarity of illustration, surgical guide 40 and anatomy are not shown.) Overall, tool 700 facilitates advancement of the implant toward the sphenopalatine ganglion (SPG) of a subject.

Typically, distal tip portion 720 plugs into surgical guide 40 to facilitate accurate advancement of neural stimulator implant 320 through guide hole 6 in surgical guide 40. Handle 600 comprises a slide-bar 570, which is slidable with respect to handle 600. Slide-bar 570 is typically locked in place, until it is released by a release mechanism 730 (e.g., by turning a knob on handle 600), in order to allow advancement of the neural stimulator implant through the guide hole and into the greater palatine canal.

An operating physician typically slides slide-bar 570 along handle 600 in order to advance implant 320 out of tool 700 and distally through guide hole 6. Additionally, slide-bar 570 provides steering functionality for facilitating orientation of the implant in the greater palatine canal. Advancement of slide-bar 570 with respect to handle 600 advances the implant through the canal.

For some applications, slide-bar 570 is rotated as indicated by arrow 130, in order to orient implant 320 within the greater palatine canal. Typically, a distal-most portion of implant 320 is oriented at a non-zero angle with respect to a longitudinal axis of the implant, such that the implant may be steered in the palatine canal in an analogous fashion to that in which a steerable guidewire is steered in the vasculature of a subject.

For some applications, the passage of implant 320 into the greater palatine canal is facilitated by image-guided surgical techniques, e.g., using optical fiducial markers 500, 510 and 520 on tool 700. Two or more cameras 16 are used to image markers 500, 510, and 520. An image-guided surgery processor 18 coupled to receive the image data from the cameras utilizes location data derived from markers 500, 510 and 520, in combination with fiducial markers on the subject (e.g., placed on surgical guide 40, or the teeth, face or a head of the subject) to register pre-operative CT data (showing bony structures in general and the greater palatine canal in particular) with the current position of the tool and thereby facilitate steering and advancement of implant 320 through the greater palatine canal.

Alternatively or additionally, the image-guided surgery processor utilizes location data derived from markers 500, 510 and 520 in combination with registration data obtained by (a) contacting a tool with a fiducial marker to multiple spots on the subject's head that can also be identified in the pre-operative CT image, and/or (b) visualizing markers 500, 510, and/or 520 when distal tip portion 720 is secured to surgical guide 40.

For some applications (in addition to or instead of using markers 500, 510, and 520), handle 600 comprises a linear and/or an angular encoder configured to facilitate recording of location data indicative of the current position and orientation of neural stimulator implant 320.

Reference is made to FIG. 7, which is a schematic illustration of implantation tool 700, generally as described herein with reference to FIG. 6. For some applications, slide-bar 570 of handle 600 comprises a distal portion 65 and a proximal portion 64, which are held connected to each other by first and second magnetic elements 85 and 84 coupled to the proximal and distal portion of slide-bar 570 and magnetically coupled to each other. Proximal portion 64 of slide-bar 570 is coupled to implant 320 such that distal advancement of proximal portion 64 of the slide-bar produces distal advancement of the implant. Typically, the physician advances the slide-bar by gripping distal portion 65 and applying a distally-directed force thereto, such that the magnetic coupling causes proximal portion 64 to advance distally, and thereby cause distal advancement of implant 320. If the force applied to distal portion 65 of slide-bar 570 in a distal direction exceeds a threshold (e.g., due to advancement of the implant being impeded), this typically breaks the coupling between the first and second magnetic elements, thereby discontinuing advancement of implant 320 and alerting the operating physician to an issue relating to the proper placement of implant 320.

Reference is made to FIG. 8, which is a schematic illustration of neural stimulator implant 320 extending from distal portion 720 of tool 700, in accordance with some applications of the present invention. (Other components of tool 700 are labeled 721 in FIG. 8). For some applications, tool 700 comprises at a distal portion thereof, a stainless steel tube 780 configured to engage a locking element 350 of implant 320. An engaging element 781 is configured to engage locking element 350 of implant 320 (shown in FIG. 8 as a ball by way of illustration and not limitation). Typically, activation of an implant-release mechanism 630 (e.g., by turning a knob as shown in FIG. 6) causes engaging element 781 to disengage from locking element 350, allowing all implantation apparatus in the greater palatine canal to be withdrawn, generally without dislodging implant 320 from its implantation location near the SPG.

Typically, tube 780 is shaped to define a series of slits 324 longitudinally aligned along tool 700, each slit disposed at an angular offset (e.g., a 180 degree offset as shown in FIG. 8, or alternatively at a 90 degree offset, not shown) from an adjacent one of the slits. The slits permit tube 780 to bend in a range of directions, e.g., in any direction, to facilitate advancement of the implant through the greater palatine canal.

Implant 320 is generally flexible but typically also comprises a rigid portion 321 which houses a receiving coil 322 configured to receive power from a remote power source to power implant 320.

Reference is now made to FIGS. 9A-11, which are different views of implant 320, in accordance with some applications of the present invention. As shown, implant 320 comprises proximal 352 and distal 354 portions. Implant 320 is a generally flexible, elongate implant having electrodes (e.g. a dome electrode 12 and a second electrode 14) at the distal portion thereof and an unconstrained shape that is curved, i.e., bent, in a vicinity of the distal portion (e.g., proximal to electrode 14, or between electrodes 12 and 14). FIGS. 9A-B and 10 show implant 320 in a straight configuration. Typically, following the advancing of the implant and deployment thereof in the vicinity of the SPG, distal portion 354 of the implant is constrained and shaped differently due to the anatomy of the canal compared to its unconstrained shape. For example, distal portion 354 may be generally straight in the vicinity of the SPG, based on the anatomy of some subjects, or distal portion 354 may be curved at its implantation site in the vicinity of the SPG.

Implant 320, in particular distal portion 354, is typically configured to puncture oral mucosa of the subject in order to allow advancement of implant 320 into the greater palatine canal. For some applications, implant 320 is not configured to puncture the oral mucosa, but instead a distal portion of tool 700 is configured to puncture oral mucosa.

It is noted that for some applications, implant 320 comprises two or more portions of electronic circuitry comprising multiple circuitry units 326, at discrete longitudinal sites along implant 320 (shown in FIG. 10). Typically, the electronic circuitry is divided into first and second portions 17 and 19, which are coupled respectively to proximal and distal sites of implantable neural stimulator 320 that are flexibly coupled to each other. Division of the electronic circuitry into two or more portions typically facilitates smooth advancement of the implant in the canal.

For some applications, a flexible, connecting element 328 (e.g., a flexible printed circuit board) extends along implant 320 and connects first and second portions 17 and 19 of the electronic circuitry. Alternatively or additionally, a structural element 325 able to withstand compressive forces associated with the implantation is used to convey distally-directed forces toward the distal end of implant 320. For example, this structural element may comprise nitinol (and for some applications is not used to convey electrical signals between the first and second portions of the electronic circuitry). Structural element 325 comprising nitinol typically has a trained natural curve, which enables steering of implant 320 by rotating the handle 600 of tool 700 (FIG. 6). The curve in element 325 could be as shown in FIG. 11, or between the two electrodes on distal portion 354, or within 15 mm of the very distal tip.

FIG. 11 shows neural stimulator implant 320 having a curved or bent distal end, as described hereinabove, in accordance with some applications of the present invention.

Reference is made to FIGS. 1-12C. For some applications, a surface shaped to define a guiding groove is generated (typically by a 3D printing process) based on CT data obtained by imaging the subject. Based on the CT data, the guiding groove is shaped in accordance with the subject's anatomy in order to guide the implant to the desired anatomical site, e.g., to guide steering of neural stimulator implants 32 and/or 320 through the greater palatine canal to the vicinity of the sphenopalatine ganglion (SPG).

As shown in FIG. 12, a delivery tool, e.g., implantation tool 700, comprises a surface shaped to define a curved guide groove 920 at a proximal portion 710 of the delivery tool. Curved guide groove 920 is generated based on data obtained by imaging the anatomy of the subject, e.g., the greater palatine canal. A guiding pin 940 is typically disposed within curved guide groove 920, and is configured such that advancement of slide-bar 570 with respect to proximal portion 710 produces (1) relative motion of guiding pin 940 with respect to curved guide groove 920, and (2) rotation of slide-bar 570 with respect to a longitudinal axis of tool 700.

Typically, as the operating physician slides slide-bar 570 along handle 600, guide groove 920 correctly guides the pin, thereby steering the implant in the canal (i.e., by causing rotation of slide-bar 570 as indicated by arrow 130 in FIG. 6, at the correct point in the longitudinal advancement of slide-bar 570 to cause a corresponding steering of implants 32 and/or 320).

For some applications, guiding pin 940 is attached to implantation tool 700, e.g., guiding pin 940 is fixedly coupled to slide-bar 570 of tool 700. For such applications, the surface shaped to define curved guide groove 920 is a surface of tool 700. For other applications, guiding pin 940 is attached to tool 700 (e.g., to handle 600 and not to the slide-bar) and slide-bar 570 is shaped to define the surface with curved guide groove 920.

It is noted that these applications using the guiding groove may, but typically do not, utilize optical markers 500, 510, or 520, or many other electronic surgical guidance techniques known in the art. For some applications, the techniques described in this paragraph may be used for advancement of other tools, in sites other than the greater palatine canal (e.g., to facilitate endoscopic sinus surgery, or vascular catheterizations).

Reference is made to FIGS. 3A-B and FIG. 13. For some applications, surgical guide 40 is generated based on data from both a CT scan and an intra-oral scan. For such applications, an intra-oral scan of the upper palate of the subject is performed in addition to the CT scan, and the data from both scans are registered for preparation of surgical guide 40.

An intra-oral scan typically contributes to fabrication of a better-fitting surgical guide 40 by providing high-resolution data of the upper palate including mapping of soft-tissue anatomy such as oral mucosa. For example, a portion of surgical guide 40 that corresponds to a surface of gum tissue of the subject is typically shaped in a curved manner that matches curvature of the gum tissue.

Thus, hole 6 is properly placed over the soft tissue that covers the greater palatine foramen. Having the surgical guide fit better over the oral mucosa typically facilitates optimal puncturing and penetration of the greater palatine foramen.

As described hereinabove, data obtained from the CT scan regarding bone and hard tissue of the subject, are typically used to determine the location and angle of implant insertion as well as guiding advancement of the implant to the SPG. Combining the data from both the CT scan and the intra-oral scan typically results in an enhanced surgical guide 40 in which both bone structure and the shape of soft tissue of the oral cavity are both reflected in surgical guide 40.

FIG. 13 is a block diagram showing steps of obtaining both CT scan data and intra-oral scan data for preparation of a surgical guide, in accordance with some applications of the present invention. Typically, in step 80, a subject in need of electrical stimulation of the SPG is identified. A CT scan and an intra-oral scan are then performed, as shown in steps 81 and 82. In step 83 the data from the CT and intra-oral scans are registered, and subsequently the surgical guide is planned and fabricated using the data from both the CT and intra-oral scanning (steps 86 and 87). As described hereinabove, surgical guide 40 is typically fabricated by three-dimensional printing techniques.

It is however noted that for some applications, surgical guide 40 is generated based on CT data only. Alternatively, for some applications, surgical guide 40 is generated based on intra-oral scan data only.

For some applications in which surgical guide 40 is generated based on intra-oral scan data only, a CT scan is performed after surgical guide 40 is generated. For example, CT data of the subject may be acquired while surgical guide 40 is disposed within the oral cavity, and registration of surgical guide 40 with respect to hard tissue of the anatomy may be performed using one or more markers affixed to surgical guide 40, and/or using features of the anatomy (e.g., teeth) that are imaged in the CT scan and in the intra-oral scan. The CT data typically guide the surgeon to drill a hole in surgical guide 40 at a site on the surgical guide that corresponds to the greater palatine foramen of the subject. For example, this drilling may be facilitated by markers on the drill, as described hereinabove. Subsequently, to drilling the hole, surgical guide 40 may be placed in the mouth and used to facilitate a procedure, as described hereinabove.

It will be appreciated by persons skilled in the art that the present invention is not limited to what has been particularly shown and described hereinabove. Rather, the scope of the present invention includes both combinations and subcombinations of the various features described hereinabove, as well as variations and modifications thereof that are not in the prior art, which would occur to persons skilled in the art upon reading the foregoing description.

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Juristische Ereignisse
DatumCodeEreignisBeschreibung
1. Juni 2015ASAssignment
Owner name: BRAINSGATE LTD., ISRAEL
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DAYAN, AVINOAM;DVORSKY, ISRAEL;ALTMAN, HERNAN;SIGNING DATES FROM 20150512 TO 20150514;REEL/FRAME:035751/0984