WO1982001816A1 - Meniscus prosthesis - Google Patents

Meniscus prosthesis Download PDF

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Publication number
WO1982001816A1
WO1982001816A1 PCT/US1981/001520 US8101520W WO8201816A1 WO 1982001816 A1 WO1982001816 A1 WO 1982001816A1 US 8101520 W US8101520 W US 8101520W WO 8201816 A1 WO8201816 A1 WO 8201816A1
Authority
WO
WIPO (PCT)
Prior art keywords
knee
human
prosthetic device
meniscus
space
Prior art date
Application number
PCT/US1981/001520
Other languages
French (fr)
Inventor
Corning Corp Dow
Charles H Kenny
Original Assignee
Dow Corning
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Corning filed Critical Dow Corning
Priority to AU78921/81A priority Critical patent/AU7892181A/en
Priority to BR8108895A priority patent/BR8108895A/en
Publication of WO1982001816A1 publication Critical patent/WO1982001816A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A61F2/3872—Meniscus for implantation between the natural bone surfaces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/21—Silicone

Definitions

  • prosthetic devices have as their primary objective the replacement of natural bodily components which may have become diseased or damaged while at the same time preserving the natural bodily function associated with the replaced organ, limb or other body component.
  • the prosthetic replacement of natural body components should not be confused, however, with the natural transplantion of a similar living organ, limb or other body component.
  • Prosthetic devices are totally man-made, being constructed primarily of synthetic materials while transplantation is concerned with the replacement of a natural body organ or component received from a human donor.
  • the prosthetic devices constructed primarily from such synthetic materials must, of course, be compatible with living human tissue and, additionally, must be capable of performing the bodily function of the removed natural component.
  • a successful prosthetic device will last for an indefinite period of time without noticeable degeneration due to the inherent properties of the synthetic materials utilized.
  • the present invention relates to a type of prosthetic device utilized in a human knee.
  • the knee is a bicondylar joint formed by the articulation between the condyles of the femur and the articular cartilage of the tibia.
  • a prosthetic device for a human knee is provided such that the articulating cartilage of the femur and tibia remains totally intact.
  • the prosthetic device according to the present invention is not intended to be surgically cemented in place.
  • the device is designed to provide a natural substitute for damaged or diseased components in the knee joint area, such as, for example, arthritic conditions, damage due to automobile or athletic injuries, and the like.
  • the device according to the present invention can be easily manufactured, and more efficiently inserted into the human knee, so that manufacturing costs and the cost of surgical services are reduced compared to the conventional prosthetic devices.
  • the prosthetic device according to the present invention may be manufactured in varying sizes conforming to the varying sizes of the human body and, in addition, "the inherent varying size of the inner and outer condyle of the femur.
  • FIGURE 1 is a top view of a representative medial meniscus prosthetic device for a human right knee
  • FIGURE 2 is a lateral view of the device of FIGURE
  • FIGURE 3 is a medial view of the device of FIGURE
  • FIGURES 4 and 5 are cross-sectional views taken along lines 4-4 and 5-5, respectively, of FIGURE 1;
  • FIGURE 6 is a posterior view of a human right knee in extension showing the device of FIGURE 1 and a corresponding lateral device in position;
  • FIGURE 7 is a medial view of a human right knee in extension showing the representative medial device of FIGURE 1 in position;
  • FIGURE 8 is a medial view of a human right knee in flexion showing the translational movement of the representative medial device of FIGURE 1.
  • FIGURE 1 The representative embodiment of the present invention is illustrated generally in FIGURE 1 wherein the prosthetic device for a human knee is shown as a medial device for placement in a human right knee. It should be understood that the symmetry of the human body allows for the general representative device depicted in FIGURE 1 to be capable of performing its intended function in both the medial and lateral positions of a human right knee, with the devices for the left knee being generally a mirror image of the right knee devices. While the basic embodiment of the present invention remains unchanged, the varying sizes of the human knee coupled with the inherent varying size of the inner and outer condyles requires that these variables be taken into account when sizing a device of the present invention for placement in a human knee.
  • the medial meniscus prosthetic device for a human right knee is depicted in the drawings, it should be understood that the lateral meniscus device for the human right knee is generally a mirror image thereof, while the medial and lateral meniscus devices for a human left knee are generally mirror images of the respective devices for a human right knee.
  • the representative medial meniscus prosthetic device 10 generally is a C-shaped structure having the terminal ends 11, 12 in close proximity to one another and defining a space 13 therebetween.
  • the generally circular structure of the device additionally defines an inner space 14 with which a femoral condyle interacts.
  • the device in its preferred embodiment has two raised prominences 15, 16 on. each of the terminal ends of the prosthetic device.
  • the prominences 15, 16 can be seen more clearly in FIGURE 2 viewing the meniscus prosthetic device 10 from the lateral side wherein the prominences 15, 16 are noticeably raised above the general surface of the device 10.
  • the prominences 15, 16, when properly placed in a human knee superiorly enter the space formed by the femoral condyles and thus secure the prosthetic device in position. Additionally, the prominences 15, 16 also encourage translational movement of the device over the articulating surfaces when properly positioned in the knee.
  • Sutures 17 can be seen in FIGURE 1 at the anterior, posterior and medial positions of the prosthetic device 10. As stated above, the prominences 15, 16 can sufficiently hold the meniscus prosthetic device 10 in proper position. However, a physician in his judgment, may wish to utilize the optional sutures 17 to further secure the meniscus prosthetic device 10 to surrounding soft tissues in the knee area. Furthermore, it is presently conceived that a meniscus prosthetic device 10 can be constructed without prominences 15, 16, in which case either sutures 17, fibrous tissue ingrowth into a porous border, or a combination thereof, would be utilized to securely position the device.
  • FIGURE 5 is a cross-section of the device showing prominence 16 and shows the increased cross-sectional area thereof relative to the cross-sectional area of FIGURE 4.
  • FIGURE 6 depicts the posterior view of a human right knee joint with the medial and lateral meniscus devices 10 and 60, respectively, in proper position.
  • the medial meniscus device 10 is generally that depicted by FIGURES 1-3, while the lateral meniscus prosthetic device 60 for the right knee is generally a mirror image thereof.
  • the right knee medial device 10 generally rests between the inner condyle 61 of the right femur bone 62 and the articular cartilage 63 of the tibia bone 64.
  • the right knee lateral meniscus prosthetic device 60 is positioned between the outer condyle 65 of the right femur bone 62 and the articular cartilage 63 of the tibia 64.
  • the prominence 16 of the medial device device and the corresponding prominence 16A of the lateral device can be seen in FIGURE 6 as superiorly extending into the space 66 defined by the inner and outer condyles 61 and 65, respectively, of the femur bone 62.
  • a suture, plurality of sutures, fibrous tissue ingrowth into a porous border, or a combination thereof may be utilized to further secure the meniscus device to the surrounding soft tissue, such as, for example, the medial collateral ligament, the lateral collateral ligament, or the like.
  • FIGURE 7 wherein a medial view of a human right knee in extension showing the medial meniscus prosthetic device 10 in proper position, it can be seen that the prosthetic device 10 is positioned between the inner condyle 51 of the femur bone 62 and the articular cartilage 63 of the tibia 64. It should be particularly noted that the femoral condyle articular cartilage 70 and the tibial articular cartilage 63 are intact.
  • An optional suture 17 can be seen in FIGURE 7 as being attached to the medial collateral ligament 72 for further securement of the medial meniscus prosthetic device 10 as desired by the attending physician.
  • FIGURE 8 wherein a medial view of a human right knee during flexion is depicted, it can be seen that the medial meniscus prosthetic device 10 is moved posteriorly from position A to position B with the corresponding flexion of the knee. Position A and postion B represent the maximum positional movement during flexion. It should, therefore, be understood that the prosthetic device can translate to any position therebetween and, additionally, slightly rotate according to the natural movement of the knee.
  • the prosthetic device of the present invention may be constructed from an elastic, self-supporting material, such as, for example, silicone rubber.
  • the prosthetic device 10 can, thus, be elastically deformed, and recover from such structural deformation readily. Therefore, in a method of inserting a meniscus prosthetic device of the present invention, and again referring to the representative medial meniscus prosthetic device 10 of FIGURE 1, opposing forces may be applied to the terminal ends 11, 12 of the prosthetic device 10 enlarging the corresponding space 13 defined between the terminal ends 11, 12. With the force thus applied, the attending physician can then insert the meniscus device between the femoral condyle and the tibial articular cartilage.
  • the opposing forces previously applied can be released causing the prominences 15, 16 to enter the space defined by the femoral condyles.
  • the prominences 15, 16 secure the device while, simultaneously, encouraging anterior-posterior translation of the device during knee flexion.
  • a meniscus prosthetic device and method of inserting same has been provided that prevent and reverse degenerative changes in the knee joint.
  • the meniscus prosthetic device of the present invention can be easily manufactured and inserted in a patient's knee without the necessity of removing or altering the femoral articular cartilage of the condyles or the tibial articular cartilage.
  • the meniscus device of the present invention freely translates over the articulating surfaces of the tibia and does not have to firmly attach thereto.

Abstract

A meniscus prosthetic device (10) for a human knee joint can be inserted into the knee joint so that the articulating cartilage in the knee totally remains intact. The prosthetic device (10) translates between the articulating cartilage during normal knee movement. Insertion of the prosthetic device (10) is accomplished by applying force on the ends of the device (10), thereby elastically spreading them, and placing the device (10) between the tibial articulating cartilage (63) and one of the femoral condyles (61, 65). The forces thus applied can then be released causing the device (10) to conform to its original C-shape. Prominences (15, 16) on the ends of the device (10) may superiorly extended into the space (66) defined by the femoral condyles (61, 65), thereby securing the device in place.

Description

MENISCUS PROSTHESIS
BACKGROUND AND SUMMARY OF THE INVENTION
In recent years, medical science and biological engineers have been developing prosthetic devices to replace natural components of the human body. The prosthetic devices have as their primary objective the replacement of natural bodily components which may have become diseased or damaged while at the same time preserving the natural bodily function associated with the replaced organ, limb or other body component. The prosthetic replacement of natural body components should not be confused, however, with the natural transplantion of a similar living organ, limb or other body component. Prosthetic devices are totally man-made, being constructed primarily of synthetic materials while transplantation is concerned with the replacement of a natural body organ or component received from a human donor.
The prosthetic devices constructed primarily from such synthetic materials must, of course, be compatible with living human tissue and, additionally, must be capable of performing the bodily function of the removed natural component. A successful prosthetic device will last for an indefinite period of time without noticeable degeneration due to the inherent properties of the synthetic materials utilized. The present invention relates to a type of prosthetic device utilized in a human knee. The knee is a bicondylar joint formed by the articulation between the condyles of the femur and the articular cartilage of the tibia.
Typical conventional prosthetic devices for the knee are shown in U.S. Patents 3,924,277 (Freeman et al., issued December 9, 1975), 4,081,866 (Upshaw et al., issued April 4, 1978), 4,207,627 (Cloutier, issued June 17, 1980), RE. 29,757 (Helfet, reissued September 12, 1978), and 3,869,731 (Waugh et al., issued March 11, 1975) (the disclosures of which are herein incorporated by reference herein). The major problem associated with the conventional knee joint prosthetic devices is the necessity of surgically removing or altering the articulating cartilage of both the femur and tibia. Additionally, many conventional prosthetic devices require that the device be fixedly secured to the femur and tibia by means of surgical cement or the like. The necessity for removing or altering the femoral and tibial cartilage prior to the implantation of the conventional prosthetic devices increases the cost of surgical services associated with such implantation.
According to the present invention, however, a prosthetic device for a human knee is provided such that the articulating cartilage of the femur and tibia remains totally intact. Additionally, the prosthetic device according to the present invention is not intended to be surgically cemented in place. The device is designed to provide a natural substitute for damaged or diseased components in the knee joint area, such as, for example, arthritic conditions, damage due to automobile or athletic injuries, and the like. The device according to the present invention can be easily manufactured, and more efficiently inserted into the human knee, so that manufacturing costs and the cost of surgical services are reduced compared to the conventional prosthetic devices.
The prosthetic device according to the present invention may be manufactured in varying sizes conforming to the varying sizes of the human body and, in addition, "the inherent varying size of the inner and outer condyle of the femur.
Therefore, it is a primary object of the present invention to provide a prosthetic device which may be easily manufactured and quickly positioned by surgical methods, without requiring the surgical removal or alteration of the femur and tibial articulating surfaces. This and other objects of the invention will become clear from an inspection of the detailed description of the invention, and from the appended claims.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGURE 1 is a top view of a representative medial meniscus prosthetic device for a human right knee;
FIGURE 2 is a lateral view of the device of FIGURE
1;
FIGURE 3 is a medial view of the device of FIGURE
1;
FIGURES 4 and 5 are cross-sectional views taken along lines 4-4 and 5-5, respectively, of FIGURE 1;
FIGURE 6 is a posterior view of a human right knee in extension showing the device of FIGURE 1 and a corresponding lateral device in position;
FIGURE 7 is a medial view of a human right knee in extension showing the representative medial device of FIGURE 1 in position; and
FIGURE 8 is a medial view of a human right knee in flexion showing the translational movement of the representative medial device of FIGURE 1.
DETAILED DESCRIPTION OF THE INVENTION
The representative embodiment of the present invention is illustrated generally in FIGURE 1 wherein the prosthetic device for a human knee is shown as a medial device for placement in a human right knee. It should be understood that the symmetry of the human body allows for the general representative device depicted in FIGURE 1 to be capable of performing its intended function in both the medial and lateral positions of a human right knee, with the devices for the left knee being generally a mirror image of the right knee devices. While the basic embodiment of the present invention remains unchanged, the varying sizes of the human knee coupled with the inherent varying size of the inner and outer condyles requires that these variables be taken into account when sizing a device of the present invention for placement in a human knee. Therefore, while only the medial meniscus prosthetic device for a human right knee is depicted in the drawings, it should be understood that the lateral meniscus device for the human right knee is generally a mirror image thereof, while the medial and lateral meniscus devices for a human left knee are generally mirror images of the respective devices for a human right knee.
Referring more specifically to FIGURE 1, it is seen that the representative medial meniscus prosthetic device 10 generally is a C-shaped structure having the terminal ends 11, 12 in close proximity to one another and defining a space 13 therebetween. The generally circular structure of the device additionally defines an inner space 14 with which a femoral condyle interacts. The device in its preferred embodiment has two raised prominences 15, 16 on. each of the terminal ends of the prosthetic device. The prominences 15, 16 can be seen more clearly in FIGURE 2 viewing the meniscus prosthetic device 10 from the lateral side wherein the prominences 15, 16 are noticeably raised above the general surface of the device 10.
The prominences 15, 16, when properly placed in a human knee superiorly enter the space formed by the femoral condyles and thus secure the prosthetic device in position. Additionally, the prominences 15, 16 also encourage translational movement of the device over the articulating surfaces when properly positioned in the knee. Sutures 17 can be seen in FIGURE 1 at the anterior, posterior and medial positions of the prosthetic device 10. As stated above, the prominences 15, 16 can sufficiently hold the meniscus prosthetic device 10 in proper position. However, a physician in his judgment, may wish to utilize the optional sutures 17 to further secure the meniscus prosthetic device 10 to surrounding soft tissues in the knee area. Furthermore, it is presently conceived that a meniscus prosthetic device 10 can be constructed without prominences 15, 16, in which case either sutures 17, fibrous tissue ingrowth into a porous border, or a combination thereof, would be utilized to securely position the device.
The cross-sectional area of the exterior portion 40 of the prosthetic device 10 when viewed in FIGURE 4, is greater than the cross-sectional area of the interior portion 42. The change in cross-sectional area is gradual- In this manner, the femoral condyle can interact with and rest in the depressed portion formed by the change in cross-sectional area. FIGURE 5 is a cross-section of the device showing prominence 16 and shows the increased cross-sectional area thereof relative to the cross-sectional area of FIGURE 4.
FIGURE 6 depicts the posterior view of a human right knee joint with the medial and lateral meniscus devices 10 and 60, respectively, in proper position. As stated above, for the right knee, the medial meniscus device 10 is generally that depicted by FIGURES 1-3, while the lateral meniscus prosthetic device 60 for the right knee is generally a mirror image thereof. The right knee medial device 10 generally rests between the inner condyle 61 of the right femur bone 62 and the articular cartilage 63 of the tibia bone 64. Similarly, the right knee lateral meniscus prosthetic device 60 is positioned between the outer condyle 65 of the right femur bone 62 and the articular cartilage 63 of the tibia 64. The prominence 16 of the medial device device and the corresponding prominence 16A of the lateral device can be seen in FIGURE 6 as superiorly extending into the space 66 defined by the inner and outer condyles 61 and 65, respectively, of the femur bone 62. Optionally, a suture, plurality of sutures, fibrous tissue ingrowth into a porous border, or a combination thereof, may be utilized to further secure the meniscus device to the surrounding soft tissue, such as, for example, the medial collateral ligament, the lateral collateral ligament, or the like. Referring now more specifically to FIGURE 7, wherein a medial view of a human right knee in extension showing the medial meniscus prosthetic device 10 in proper position, it can be seen that the prosthetic device 10 is positioned between the inner condyle 51 of the femur bone 62 and the articular cartilage 63 of the tibia 64. It should be particularly noted that the femoral condyle articular cartilage 70 and the tibial articular cartilage 63 are intact. An optional suture 17 can be seen in FIGURE 7 as being attached to the medial collateral ligament 72 for further securement of the medial meniscus prosthetic device 10 as desired by the attending physician.
Referring to FIGURE 8, wherein a medial view of a human right knee during flexion is depicted, it can be seen that the medial meniscus prosthetic device 10 is moved posteriorly from position A to position B with the corresponding flexion of the knee. Position A and postion B represent the maximum positional movement during flexion. It should, therefore, be understood that the prosthetic device can translate to any position therebetween and, additionally, slightly rotate according to the natural movement of the knee.
The prosthetic device of the present invention may be constructed from an elastic, self-supporting material, such as, for example, silicone rubber. The prosthetic device 10 can, thus, be elastically deformed, and recover from such structural deformation readily. Therefore, in a method of inserting a meniscus prosthetic device of the present invention, and again referring to the representative medial meniscus prosthetic device 10 of FIGURE 1, opposing forces may be applied to the terminal ends 11, 12 of the prosthetic device 10 enlarging the corresponding space 13 defined between the terminal ends 11, 12. With the force thus applied, the attending physician can then insert the meniscus device between the femoral condyle and the tibial articular cartilage. When the prosthetic device 10 is properly in place, the opposing forces previously applied can be released causing the prominences 15, 16 to enter the space defined by the femoral condyles. The prominences 15, 16 secure the device while, simultaneously, encouraging anterior-posterior translation of the device during knee flexion. Once again, it should be understood that the method of inserting the medial meniscus device of the right knee discussed above is also representative of the lateral device of the right knee and, in addition, is representative of the method utilized for inserting the medial and lateral devices for the left knee.
Thus, it can be seen that according to the present invention a meniscus prosthetic device and method of inserting same has been provided that prevent and reverse degenerative changes in the knee joint. The meniscus prosthetic device of the present invention can be easily manufactured and inserted in a patient's knee without the necessity of removing or altering the femoral articular cartilage of the condyles or the tibial articular cartilage. Furthermore, the meniscus device of the present invention freely translates over the articulating surfaces of the tibia and does not have to firmly attach thereto.
While the invention has been herein shown and described in what is presently conceived to be the most practical and preferred embodiment thereof, it will be apparent to those of ordinary skill in the art that many modifications may be made thereof within the scope of the invention, which scope is to be accorded the broadest interpretation of the appended claims so as to encompass all equivalent structures and methods.

Claims

CLAIMS:
1. A meniscus prosthetic device to prevent and reverse degenerative changes in a human knee comprising: a flexible structure (10) for replacing natural components of a condylar joint (61, 65) in a human knee characterized in that the structure has a general C-shape which defines a generally interior circular space (14), and is constructed from an elastic, self-supporting material compatible with human tissue and capable of recovering from structural deformation.
2. The device of claim 1 further characterized in that the flexible structure (10) includes anterior and posterior prominences (15, 16) opposingly disposed at each of the terminal ends (11, 12) of said structure, said prominences (15, 16) being adapted to superior extension into the space (66) defined by the femoral condyles (61, 65) of a human knee and having a greater cross-sectional area at the exterior portion (40) of said structure (10) relative to the corresponding interior portion (42) thereof.
3. The device of claims 1 or 2 wherein said elastic, self-supporting material is silicone rubber.
4. The device of claims 1 or 2 further characterized in having a means for securing the flexible structure (10) to surrounding soft tissue.
5. The device of claim 4 wherein said means for securing structure (10) is a suture (17) or a proous border for tissue ingrowth.
6. The device of claims 1 or 2 wherein the transition in cross-section from said exterior portion (4) to said interior portion (42) is gradual.
7. A method of inserting in a human knee without removal or alteration of the articular cartilage (63) therein a meniscus prosthetic device comprising a C-shaped structure (10) formed of bio-compatible, flexible and resilient material, and having terminal ends (11, 12) defining a space (13) therebetween, the metlrod characterized by the steps of:
(a) applying opposing forces upon the terminal ends (11, 12) of the device so that the device is deformed and the space (13) defined between the terminal ends (11, 12) is enlarged;
(b) positioning the device deformed according to step (a) between one femoral condyle (61, 65) and the corresponding tibial articular cartilage (63); and
(c) releasing the opposing forces applied in step (a) so that the device is held in place between one femoral condyle (61, 65) and the corresponding tibial articular cartilage (63).
The method of claim 7 further characterized by the step of:
(d) securing the device with at least one suture
(17).
9. The method of claim 7 further characterized by: (d) providing the device with a porous border to enable fibrous tissue ingrowth.
PCT/US1981/001520 1980-11-28 1981-11-16 Meniscus prosthesis WO1982001816A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU78921/81A AU7892181A (en) 1980-11-28 1981-11-16 Meniscus prosthesis
BR8108895A BR8108895A (en) 1980-11-28 1981-11-16 MENISCO PROSTHESIS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/211,292 US4344193A (en) 1980-11-28 1980-11-28 Meniscus prosthesis
US211292801128 1980-11-28

Publications (1)

Publication Number Publication Date
WO1982001816A1 true WO1982001816A1 (en) 1982-06-10

Family

ID=22786302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1981/001520 WO1982001816A1 (en) 1980-11-28 1981-11-16 Meniscus prosthesis

Country Status (6)

Country Link
US (1) US4344193A (en)
EP (1) EP0053460A1 (en)
JP (1) JPS57501816A (en)
BR (1) BR8108895A (en)
CA (1) CA1193803A (en)
WO (1) WO1982001816A1 (en)

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EP0053460A1 (en) 1982-06-09
JPS57501816A (en) 1982-10-14
BR8108895A (en) 1982-10-26
US4344193A (en) 1982-08-17
CA1193803A (en) 1985-09-24

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