WO1984001705A1 - Cardio-respiratory monitor apparatus & method - Google Patents
Cardio-respiratory monitor apparatus & method Download PDFInfo
- Publication number
- WO1984001705A1 WO1984001705A1 PCT/GB1983/000276 GB8300276W WO8401705A1 WO 1984001705 A1 WO1984001705 A1 WO 1984001705A1 GB 8300276 W GB8300276 W GB 8300276W WO 8401705 A1 WO8401705 A1 WO 8401705A1
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- WIPO (PCT)
- Prior art keywords
- sound
- signal
- respiratory
- cardiac
- function
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B7/00—Instruments for auscultation
- A61B7/02—Stethoscopes
- A61B7/04—Electric stethoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/0816—Measuring devices for examining respiratory frequency
Definitions
- the present invention relates to a cardio-respiratory monitor and apparatus for monitoring cardio- respiratory action.
- apnoea in humans, particularly infants, and its detection has become a matter of some importance. Particularly in the case of infants, detection of apnoea may be used to prevent or reduce the occurrence of Sudden Inf nt Death Syndrome (commonly called "Cot Death").
- monitors have been designed for detecting apnoea but they have hitherto relied upon detection of respiratory movements or movements of the body. These have frequently been in the form of pressure detectors which have either been placed under the body to detect movement of the body or attached to the chest to detect movement of the chest, the variation of pressure within a pressure capsule being used to provide an indication signal of respiratory function.
- the present invention provides a method and apparatus for detecting not only respiratory function but also detecting cardiac function-
- the present invention provides, according to one aspect, a cardio-respiratory monitor apparatus comprising a sound detector for detecting sound from a body, means for passing a signal representing the
- OMPI sound detected to an analyser apparatus sai d analyser apparatus including means to distinguish the signal relati ng to the respiratory function and the signal relating to the cardiac function, and means to moni tor thes e separate si gnal s . It has been determined by experiment that, in general terms, both cardiac and respiratory function produce sounds which are of different frequencies which are separate from one another . In practi ce the cardi ac f unction produces sounds of a frequency of approximately 30 to 180 Hz and the respiratory function provides sounds of a general frequency range of 200 to 950 Hz.
- the monitor apparatus therefore includes means to separate these frequencies and to monitor them separately.
- the sound detector may compri se a mi crophone including means to attach the microphone to the chest wall.
- the means to attach the microphone to the chest wall may include means for providing a space between the microphone and the chest wall and in a pref erred arrangement thi s may be in the form adhesive *0" ings .
- the monitor means for monitoring the two sound related signals may include a phase locking means in which, for example, in the case of the cardiac monitor, will analyse the rate of heart beat and will note any missing heart beats.
- the present invention provides a method of monitoring life function comprising detecting sound from a body, analysing a signal derived from the sound detected to provide two output signals, one of which relates to the sound signal relating to respiratory function and the other of which relates to the sound signal relating to the cardiac function, and monitoring these separate signals.
- the present invention also provides a method of determining life function comprising detecting sound from the chest of a human body, determining cardiac function from a first frequency range of detected sound and determining respiratory function from a second frequency range of detected sound.
- FIG. 1 is a diagrammatic perspective view of a cardio-respiratory monitor apparatus .according to the invention.
- Figure 2 is a block diagram showing the process steps in a first stage of the analysis of the respiratory signal.
- Figure 3 is a block diagram showing the process steps in a second stage of the analysis of the cardiac signal,
- Figures 4A to 4E show signal waveforms in the process steps of the analysis of the respiratory signal, r
- Figure 5 is a block diagram of the process steps in a third stage of the analysis of the respiratory signal
- Figure 6 is a block diagram of the process steps in a fourth stage of the analysis of the respiratory signal
- Figure 7 is a block diagram showing the process steps in a first st ge of the analysis of the cardiac signal
- Figure .8 is a block ⁇ diagram showing the process steps in a second stage of the analysis of the cardiac signal.
- the monitor apparatus may be used with respect to a human subject 11 which may be an unsedated infant sleeping in a sound proofed cot in a quiet room.
- the sounds transmitted through the chest wall 10 of the human subject 11 as a result of breathing and cardiac action respectively are detected - by a single sub-miniature sensor 12 consisting of a ' combined condensor microphone and
- OMPI vibration detector applied to the chest wall 10.
- a sub-miniature electret condenser microphone housed in polytetrafluorethylene shells and applied to the chest wall 10 by adhesive "0" rings.
- the sensitivity of the microphone is 10 mV/Pa and the frequency response is uniform between 40 Hz and 3 kHz. In some instances two microphones may be used in which case the gains of each microphone/amplifier combination should be equalised before measurement.
- an absolute sound level calibration of 94 dB re 20 uPa at 1 kHz is also performed.
- the electrical signal from the sensor 12 is passed by cable 13 to a monitor unit 14 containing electronic circuits, control and display panels.
- a monitor unit 14 containing electronic circuits, control and display panels.
- the electrical output from the sensor 12 is amplified by amplifier 16 and divided into each of two high quality precision electronic filters 17, 18.
- the .first filter 17 is set to pass waveforms with frequencies common to the cardiac sounds, that is between .20 and 200 Hz with an attenuation rate at -each .limit of 24 dB/octave.
- the second filter 18 is set to pass .waveforms with frequencies common to the respiratory sounds; thus filter 18 may be a highpass filter with a lower cut off frequency of 180 Hz and an attenuation rate of 48 dB/octave " (Barr & Stroud Variable Filter EF3 UK).
- the output of each filter unit 17, 18 is phase locked and may be finely tuned externally by control 48.
- the filtered sounds may be recorded on a seven channel FM tape recorder at 38 cm/sec. During recording sound quality is monitored through an audio amplifier and headphones.
- the cardiac and respiratory signals on lines 21, 22 are respectively rectified in rectifiers 23, 24 and passed to respective means 26, 27 which pass the signals through preset amplitude and time windows which are used to generate pulses at the start of every first heart sound and towards the end of every inspiratory phase of respiration (ie towards the end of every inward breath).
- the pulses from window means 26 which signal the occurrence of the first heart sound are: 1) counted electronically by counter 28 and displayed on a front panel light-emitting diode display 29, and 2) used to activate a hear rate trend counter 31 with an external output to a visual dipslay unit 32 or plotter 33.
- the pulses from window means 27 which signal the occurrence of respiration are 1) counted electronically and displayed on a front panel light- emitting diode display 37, and 2) used to activate a respiratory rate trend counter 38 vi h an external output to a visual display unit 39 or plotter 40.
- OMPI pass to their respective but interconnecting logic alarm circuitry 41.
- an alarm 45 is activated by the occurrence of a predetermined delay in either the cardiac and/or respiratory signals. 5
- the exact combination of alarm modes can be specified on the front panel controls 42.
- the monitor is intended for medical use principally in
- background noise may also be eliminated by signal averaging techniques during frequency analysis or by subtraction of the simultaneously recorded background noise frequency spectrum.
- a specific microprocessor based extension unit 54 may be attached to an appropriate output socket 53 of -the monitor unit 14. With this addition, it is
- VDU 32,39 and 51 for each separate function and a separate plotter 33, 40, 52 for each separate function it will be understood that these may be combined as a single unit if desired.
- the single VDU then being switchable between modes in which it will show all of the signals simultaneously, or each of the signals separately and similarly, the plotter can be switched between modes in which it will plot all of the signals simultaneously (there being provided sufficient pens for the number of input signals) or a single signal at a time.
- Both inspiratory and expiratory sounds are transients consisting of random noise over a bandwidth 200 to 900 Hz.
- the resonant frequency is above 400 Hz.
- Expiration is less intense a sound than inspiration and may not be detected at all in some breaths.
- mean peak sound pressure level of the inspiratory sound is around 65 dB re 20 _ ⁇ Pa.
- the inspiratory sound normally lasts 300 to 400 msecs and the expiratory sound is shorter. There is a variable break in the sound between the two phases of respiration.- Sound intensity is related
- OMPI exponentially to air flow rate but these are related linearly over the usual operating range. Breaths whose sound level falls below the threshold of detection are usually associated with inadequate ventilation. However, slow deep breathing in quiet (non-REM) sleep may pose a problem to detection in some circumstances even though alveolar ventilation is satisfactory. Instantaneous (breath-to-breath) respiratory rates are highly variable (eg 20 to 120/min). The actual respiratory rate over one minute does not normally exceed 80.
- a single heart beat generates two sounds related to sequential cardiac valve vibrations. These are discrete, non random transients and (unlike the breathing signal) are relatively uniform from beat to beat.
- the resonant frequency is below 100 Hz.
- the "mean peak sound pressure level is 30 to 40 dB greater than that of the respiratory sounds.
- the first heart sound lasts around 70 msec and is usually longer and more intense than the second sound.
- the interval between heart sounds corresponds to the interval between the Q and T waves of an electrocardiogram ie approximately 150 to 200 msecs.
- the upper limit of hear rate is 180/min.
- the microphone 12 is a Knowles CA series insert which uses an electret film and contains an integral FET
- the microphone 12 is centrally in contact with an air space of ⁇ 5mm , sealed by the skin surface of the chest 10. Peripherally, it is in contact with a 1 cm diameter PTFE plate 1mm thick. This plate forms the contact surface of the microphone housing which consists of a polytetrafluorethylene shell containing alternate layers of expoxy resin and either dense latex foam rubber or soft polymetric elastomer.
- the microphone specification is:
- Sensitivity 10 mV/Pa (Breathing signal 0.5 mV approx.)
- the output from the microphone 12 is preamplified to give a signal of 1-4 volts peak to peak. This may increase to 10 V+ when the human subject 11 moves.
- the raw sound signal has to be handled electronically i n a s er i es of i ndi vi dual s teps .
- signal distortion and phase shift are not critical provided that sensitivity and periodicity are maintained. System delays of up to 250 secs are acceptable.
- the signal from the microphonel2 is processed in the manner shown in Figure 2.
- the signal from the microphone 12 is pre-amplified, passed to an LSM highpass filter having a cutt-off frequency of 350 Hz, the signal is then passed to an AC amplifier to amplify it by 50 times, the amplifier signal is passed to an LSM lowpass filter having a cut-off frequency of 650 Hz., and the output from * t ' he lowpass filter is again amplified in an AC amplifier by 10 times.
- the filter 18 therefore comprises both the LSM highpass filter, the LSM .lowpass filter, and the AC amplifier.
- the steps in this part of the process are illustrated in Figure 3.
- the signal from Figure 2 is rectified in rectifier 24 and integrated with a predetermined sampling rate of 6 Hz. '
- the integrator holds the peak value of each 166 msec sample.
- the energy present in each sample during a breath is adequate to provide a satisfactory sound envelope without a significant response to intervening attenuated heart sounds or background noise.
- the signal falls to the value of the noise floor (ie the noise level) between breaths.
- the output is passed from the integrator through a non-linear- gain amplifier.
- An amplitude li mit is set so that a si gnal i s detected but noise is not.
- a retr.iggerable monostable is used for this process such that when the amplitude of the sound envelope exceeds the preset threshold, a pulse is generated.
- Figure 4A shows a signal corresponding to the breath sound
- Figure 4B shows the integrated envelope of that signal
- Figure 4C the antilogged integral of the signal of Figure 4B. If the voltage limit is set to 10% above the noise floor then the signal of Figure 4D is produced and if this is then passed to the retriggerable monostable the pulse output of Figure 4E is produced.
- each pulse represents the beginning of a breath and this point is now used as a trigger.
- the pulse train needs to be "smoothed" still further to prevent inappropriate triggering.
- breaths will, if completely regular, occur no more frequently than once every 750 msecs. So a further constraint can be imposed on the pulse train - that pulses should occur no more frequently than one every 750 msecs (0.75 Hz).
- babies do not breathe regularly and very fast periods may alternate with much slower ones.
- the output from this stage is passed to the logic alarm circuit 41 and also to counter 36.
- LSM lowpass filter is passed to a DC amplifier where it is amplified by 10 times.
- the output signal from this amplifier is passed to an LSM highpass filter having a cut off frequency of 30 Hz and the output signal therefrom is amplified by an AC amplifier by 10 times.
- the amplified output is passed to a clipper .
- the filter 17 of diagrammatic Figure 1 comprises the LSM lowpass filter, DC amplifer and LSM highpass filter and AC amplifier.
- the filtered output .from the previous step is passed to an amplitude clipper module.
- This module effectively extracts the noise band between selectable amplitude limits and rejects it.
- the positive and negative parts of the . signal are then "joined up” again and amplified to a constant level.
- the sound envelope is generated by passing the signal from the previous stage to an integrated circuit in which the RMS (root mean square) value of the signal is calculated and expressed as a DC value.
- the time constant of the system is 120 to 250 msecs. This
- OMP process converts the pair of spike signals from the previous step into an "M" shaped envelope in which the first peak corresponds to the first sound and the next peak to the second heart sound.
- Thi s helps to smooth the heart signal and improves the signal stabi l i ty .
- Thi s s tep can be om i tted but f al s e triggering is more likely.
- the cardiac sound envelope activates a non-retriggerable monostable when the upstroke crosses a preset amplitude limit, set 20% below the peak amplitude level of the envelope. Further smoothing is achieved by specifying the period for which the pulse generator cannot be retriggered using a second monostable module.
- the refractory period selected is 300 msecs, accommodating heart rates approaching an upper limit of 180/min.
- this step can be performed with two variable non-retriggerable monostables, the first of which delivers a pulse of 300 msecs duration triggered on the upstroke of the sound envelope and the second monostable delivers a TTL pulse on the upstroke of the first heart pulse.
- This audio movement signal is normally in the range of 1 to 4 volts RMS after amplification. Signal levels greater than 5 volts RMS indicate additional noise. Signals greater than 7 volts RMS indicate movement or vocalisation.
- the raw sound signal is monitored by an RMS voltage window comparator with a time constant of 2 sees.
- the output from the comparator goes high for signals > 5 V RMS and low for signals ⁇ 1 V RMS.
- the outputs from the comparator are available as DC levels and also operate appropriately coloured lights automati cally .
- the above process has therefore now produced a TTL pulse for each breath and heart beat and also a high DC level which indicates movement.
- the apparatus includes digital circuitry to analyse these rates of pulses and the trend and to cause an alarm to operate if the rates and trends are outside predetermined limits which may be adjustable for age, weight and other factors.
- OMPI may be produced for home use in which expensive components such as the VDU plotter may be deleted, the apparatus si mply produci ng an alarm if predetermined parameters r egardi ng cardi ac and respiratory rate are exceeded. In such a case , the apparatus can be produced more cheaply as the electronic components can be produced in integrated circuit form.
Abstract
Life monitor apparatus and method in which a sound detector is placed on the body, the sound detected being divided into a first frequency component which relates to cardiac function and a second frequency component which relates to respiratory function. These signals are analysed and monitored.
Description
CARDIO-RESPIRATORY MONITOR APPARATUS & METHOD
The present invention relates to a cardio-respiratory monitor and apparatus for monitoring cardio- respiratory action.
The occurrence of apnoea in humans, particularly infants, and its detection has become a matter of some importance. Particularly in the case of infants, detection of apnoea may be used to prevent or reduce the occurrence of Sudden Inf nt Death Syndrome (commonly called "Cot Death").
Several monitors have been designed for detecting apnoea but they have hitherto relied upon detection of respiratory movements or movements of the body. These have frequently been in the form of pressure detectors which have either been placed under the body to detect movement of the body or attached to the chest to detect movement of the chest, the variation of pressure within a pressure capsule being used to provide an indication signal of respiratory function.
'The present invention provides a method and apparatus for detecting not only respiratory function but also detecting cardiac function-
The present invention provides, according to one aspect, a cardio-respiratory monitor apparatus comprising a sound detector for detecting sound from a body, means for passing a signal representing the
OMPI
sound detected to an analyser apparatus , sai d analyser apparatus including means to distinguish the signal relati ng to the respiratory function and the signal relating to the cardiac function, and means to moni tor thes e separate si gnal s . It has been determined by experiment that, in general terms, both cardiac and respiratory function produce sounds which are of different frequencies which are separate from one another . In practi ce the cardi ac f unction produces sounds of a frequency of approximately 30 to 180 Hz and the respiratory function provides sounds of a general frequency range of 200 to 950 Hz.
The monitor apparatus therefore includes means to separate these frequencies and to monitor them separately.
The sound detector may compri se a mi crophone including means to attach the microphone to the chest wall. The means to attach the microphone to the chest wall may include means for providing a space between the microphone and the chest wall and in a pref erred arrangement thi s may be in the form adhesive *0" ings .
In the analyser apparatus the monitor means for monitoring the two sound related signals may include a phase locking means in which, for example, in the case of the cardiac monitor, will analyse the rate of heart beat and will note any missing heart beats.
The present invention provides a method of monitoring
life function comprising detecting sound from a body, analysing a signal derived from the sound detected to provide two output signals, one of which relates to the sound signal relating to respiratory function and the other of which relates to the sound signal relating to the cardiac function, and monitoring these separate signals.
The present invention also provides a method of determining life function comprising detecting sound from the chest of a human body, determining cardiac function from a first frequency range of detected sound and determining respiratory function from a second frequency range of detected sound.
Although through the specification we refer to the use of the monitor apparatus with human beings it will be understood of course that the apparatus may be adpated for use with other mammals and may have particular use in veterinary practice.
Preferred arrangements of the invention will now be described by way of example only with reference to the accompanying drawings in which:
Figure 1 is a diagrammatic perspective view of a cardio-respiratory monitor apparatus .according to the invention,
Figure 2 is a block diagram showing the process steps in a first stage of the analysis of the respiratory signal.
Figure 3 is a block diagram showing the process steps in a second stage of the analysis of the cardiac signal,
Figures 4A to 4E show signal waveforms in the process steps of the analysis of the respiratory signal, r
Figure 5 is a block diagram of the process steps in a third stage of the analysis of the respiratory signal,
Figure 6 is a block diagram of the process steps in a fourth stage of the analysis of the respiratory signal,
Figure 7 is a block diagram showing the process steps in a first st ge of the analysis of the cardiac signal,
Figure .8 is a block ^diagram showing the process steps in a second stage of the analysis of the cardiac signal.
Referring to Figure 1, the monitor apparatus may be used with respect to a human subject 11 which may be an unsedated infant sleeping in a sound proofed cot in a quiet room. The sounds transmitted through the chest wall 10 of the human subject 11 as a result of breathing and cardiac action respectively are detected - by a single sub-miniature sensor 12 consisting of a' combined condensor microphone and
OMPI
vibration detector applied to the chest wall 10. We prefer to use a sub-miniature electret condenser microphone (Knowles Electronic Co., UK) housed in polytetrafluorethylene shells and applied to the chest wall 10 by adhesive "0" rings. The sensitivity of the microphone is 10 mV/Pa and the frequency response is uniform between 40 Hz and 3 kHz. In some instances two microphones may be used in which case the gains of each microphone/amplifier combination should be equalised before measurement. Before use an absolute sound level calibration of 94 dB re 20 uPa at 1 kHz is also performed.
The electrical signal from the sensor 12 is passed by cable 13 to a monitor unit 14 containing electronic circuits, control and display panels. Within the -monitor unit 14 the electrical output from the sensor 12 is amplified by amplifier 16 and divided into each of two high quality precision electronic filters 17, 18. The .first filter 17 is set to pass waveforms with frequencies common to the cardiac sounds, that is between .20 and 200 Hz with an attenuation rate at -each .limit of 24 dB/octave. The second filter 18 is set to pass .waveforms with frequencies common to the respiratory sounds; thus filter 18 may be a highpass filter with a lower cut off frequency of 180 Hz and an attenuation rate of 48 dB/octave "(Barr & Stroud Variable Filter EF3 UK). The output of each filter unit 17, 18 is phase locked and may be finely tuned externally by control 48.
If desired the filtered sounds may be recorded on a
seven channel FM tape recorder at 38 cm/sec. During recording sound quality is monitored through an audio amplifier and headphones.
If however it is desired to analyse and monitor the cardiac and respiratory activity in real time the cardiac and respiratory signals on lines 21, 22 are respectively rectified in rectifiers 23, 24 and passed to respective means 26, 27 which pass the signals through preset amplitude and time windows which are used to generate pulses at the start of every first heart sound and towards the end of every inspiratory phase of respiration (ie towards the end of every inward breath).
The pulses from window means 26 which signal the occurrence of the first heart sound are: 1) counted electronically by counter 28 and displayed on a front panel light-emitting diode display 29, and 2) used to activate a hear rate trend counter 31 with an external output to a visual dipslay unit 32 or plotter 33.
The pulses from window means 27 which signal the occurrence of respiration are 1) counted electronically and displayed on a front panel light- emitting diode display 37, and 2) used to activate a respiratory rate trend counter 38 vi h an external output to a visual display unit 39 or plotter 40.
The pulses from window means 26, and 27 which signal the occurrence of breathing and cardiac action also
OMPI
pass to their respective but interconnecting logic alarm circuitry 41. In general, an alarm 45 is activated by the occurrence of a predetermined delay in either the cardiac and/or respiratory signals. 5 The exact combination of alarm modes can be specified on the front panel controls 42.
In the normal baby, frequency analysis has shown that the principal heart sound components lie within the 10 band width of 30 to 180 Hz and the principal respiratory components within the range of 200 to 950 Hz.
The monitor is intended for medical use principally in
15 babies (including those born prematurely), infants and children but is also suitable for use in adults. The general age range of the patient is specified by the operator from an external control switch 43 on the front panel. Operation of the switch 43 has the effect
•20 of altering the filter and other window characteristics to the specific pattern of the heart and breathing sounds of the particular age range selected. Fine tuning is again possible if necessary in an individual case.
25
The occurrence of noise is specifically eliminated in -/the system by:
1) the use of narrow and specific frequency, amplitude 30 and time windows.
2) "phase locking of the specific cardiac and
respiratory signals.
3) provision in the logic alarm circuitry for the isolation of atypical pulse surges.
4) background noise may also be eliminated by signal averaging techniques during frequency analysis or by subtraction of the simultaneously recorded background noise frequency spectrum.
10
Where the normal respiratory sounds are complicated by the addition of high frequency polyphonic wheezes (as in asthma) or variable frequency crackles (as in some obstructive and restrictive lung conditions), these
15 events are detected by subsidiary filters 46, 47 engaged by the operation of a front panel selector switch 48. The amplitude of the wheezes or crackles on a breath-to-breath basis and/or the trend of amplitude with time are available as an external output to a
"20 visual display unit 51 or plotter 52.
A specific microprocessor based extension unit 54 may be attached to an appropriate output socket 53 of -the monitor unit 14. With this addition, it is
25 possible to generate values of tidal volume, flow rate and airways resistance from the primary input signal filtered to yield the respiratory waveform and digitised. In this case, the operator keys in the patient's body proprortions by control 56 to the
30 microprocessor extension unit and a continuous output of the selected variable or variables is available for display on"a visual display unit 57 or plotter
( OMPI
58.
Although we have shown a separate VDU 32,39 and 51 for each separate function and a separate plotter 33, 40, 52 for each separate function it will be understood that these may be combined as a single unit if desired. The single VDU then being switchable between modes in which it will show all of the signals simultaneously, or each of the signals separately and similarly, the plotter can be switched between modes in which it will plot all of the signals simultaneously (there being provided sufficient pens for the number of input signals) or a single signal at a time.
We shall now examine the various parts of the arrangement described with respect to Figure 1 in more detail.
THE RESPIRATORY SIGNAL
Both inspiratory and expiratory sounds are transients consisting of random noise over a bandwidth 200 to 900 Hz. The resonant frequency is above 400 Hz. Expiration is less intense a sound than inspiration and may not be detected at all in some breaths. The
• mean peak sound pressure level of the inspiratory sound is around 65 dB re 20 _μPa. The inspiratory sound normally lasts 300 to 400 msecs and the expiratory sound is shorter. There is a variable break in the sound between the two phases of respiration.- Sound intensity is related
OMPI
exponentially to air flow rate but these are related linearly over the usual operating range. Breaths whose sound level falls below the threshold of detection are usually associated with inadequate ventilation. However, slow deep breathing in quiet (non-REM) sleep may pose a problem to detection in some circumstances even though alveolar ventilation is satisfactory. Instantaneous (breath-to-breath) respiratory rates are highly variable (eg 20 to 120/min). The actual respiratory rate over one minute does not normally exceed 80.
THE CARDIAC SIGNAL
A single heart beat generates two sounds related to sequential cardiac valve vibrations. These are discrete, non random transients and (unlike the breathing signal) are relatively uniform from beat to beat. The resonant frequency is below 100 Hz. The "mean peak sound pressure level is 30 to 40 dB greater than that of the respiratory sounds. The first heart sound lasts around 70 msec and is usually longer and more intense than the second sound. The interval between heart sounds corresponds to the interval between the Q and T waves of an electrocardiogram ie approximately 150 to 200 msecs. The upper limit of hear rate is 180/min.
THE MICROPHONE
The microphone 12 is a Knowles CA series insert which uses an electret film and contains an integral FET
OMPI
amplifier. It is used as a combined contact condenser microphone and direct vibration detector. The microphone 12 is centrally in contact with an air space of < 5mm , sealed by the skin surface of the chest 10. Peripherally, it is in contact with a 1 cm diameter PTFE plate 1mm thick. This plate forms the contact surface of the microphone housing which consists of a polytetrafluorethylene shell containing alternate layers of expoxy resin and either dense latex foam rubber or soft polymetric elastomer.
The microphone specification is:
Size: 7.2 x 7.2 x 4.9 m Bandwidth: 20 Hz - 2 kHz
Sensitivity: 10 mV/Pa (Breathing signal 0.5 mV approx.)
Supply voltage: 0.9-20 V DC
Current drain : 0.05-O.1 mA Nominal output .impedance at .1 kHz : 1, 700 ohms .
The output from the microphone 12 is preamplified to give a signal of 1-4 volts peak to peak. This may increase to 10 V+ when the human subject 11 moves.
THE MONITOR UNIT 14
The raw sound signal has to be handled electronically i n a s er i es of i ndi vi dual s teps . Each s tep i s contained within a single module. Thi s allows independent adjustment of each individual step of the signal analysis to arrive at an optimal arrangement.
Alternatively, however, the individual modules can be integrated into a single, compact system employing integrated electronic circuits.
In handling the signal for monitoring purposes, signal distortion and phase shift are not critical provided that sensitivity and periodicity are maintained. System delays of up to 250 secs are acceptable.
PROCESSING THE RESPIRATORY SIGNAL Initial Amplification and Filtering
The signal from the microphonel2 is processed in the manner shown in Figure 2. The signal from the microphone 12 is pre-amplified, passed to an LSM highpass filter having a cutt-off frequency of 350 Hz, the signal is then passed to an AC amplifier to amplify it by 50 times, the amplifier signal is passed to an LSM lowpass filter having a cut-off frequency of 650 Hz., and the output from *t'he lowpass filter is again amplified in an AC amplifier by 10 times.
n the part of the process thus far described the filter 18 therefore comprises both the LSM highpass filter, the LSM .lowpass filter, and the AC amplifier.
Generation of Breath Sound Envelope
The steps in this part of the process are illustrated in Figure 3. The signal from Figure 2 is rectified
in rectifier 24 and integrated with a predetermined sampling rate of 6 Hz.' The integrator holds the peak value of each 166 msec sample. The energy present in each sample during a breath is adequate to provide a satisfactory sound envelope without a significant response to intervening attenuated heart sounds or background noise. The signal falls to the value of the noise floor (ie the noise level) between breaths.
To improve the signal-to-noise ratio further, ie to enhance the discrimination between the breath sound envelope and the unwanted noise integrals the output is passed from the integrator through a non-linear- gain amplifier. An "antilogarithmic" amplifier is used in which large signals are made larger and smaller ones smaller, but a squaring amplifier could be used (eg 32 = 9 and 42 = 16, so an initial signal- to-noise ratio of 4:3 (1.3) is improved to one of 16:9 (1.8) ).
Setting the Primary Trigger Level
The sound "envelope" is now used for the remainder of the triggering process .
An amplitude li mit is set so that a si gnal i s detected but noise is not. A retr.iggerable monostable is used for this process such that when the amplitude of the sound envelope exceeds the preset threshold, a pulse is generated.
The sequence of events is shown in Figures 4A to 4E.
Figure 4A shows a signal corresponding to the breath sound, Figure 4B shows the integrated envelope of that signal and Figure 4C the antilogged integral of the signal of Figure 4B. If the voltage limit is set to 10% above the noise floor then the signal of Figure 4D is produced and if this is then passed to the retriggerable monostable the pulse output of Figure 4E is produced.
From Figure 4E it will be seen that pulses coinciding with breaths of Figure 4A have been generated. The pulses start as the upward stroke of the sound envelope crosses the threshold value and end as the downward stroke crosses the same threshold level. The process is summarised in. igure 5.
Setting Subsequent Trigger Levels
The breaths of Figure 5 have now been converted to pulses of Figure 4E.
The upward stroke of each pulse represents the beginning of a breath and this point is now used as a trigger.
The pulse train needs to be "smoothed" still further to prevent inappropriate triggering. At a breathing rate of 80/min, breaths will, if completely regular, occur no more frequently than once every 750 msecs. So a further constraint can be imposed on the pulse train - that pulses should occur no more frequently than one every 750 msecs (0.75 Hz). However, babies
do not breathe regularly and very fast periods may alternate with much slower ones. Even at an instantaneous (breath-to-breath) rate of 120/min, there would be one breath every 500 msecs, so in a practical sense the most reasonable constraint is that the pulses should occur no more frequently than once every 500-750 msecs. In setting the actual maximum pulse frequency, it is of no consequence if 5-10% of breaths are actually missed and "overridden" each minute as the purpose of the monitoring is apnoea detection rather than 100% accurate .respiratory rate monitoring. Further, the vast majority of babies have average respiratory rates at or below 40/min.
The processes of this stage are illustrated in Figure 6 and the shape of the corresponding pulse for each stage is illustrated on the left hand side of Figure 6.
The output from this stage is passed to the logic alarm circuit 41 and also to counter 36.
We now deal with the signal processing for the cardiac pulse.
CARDIAC PULSE PROCESSING
Initial Amplification and Filtering
OMPI
The stages of this initial amplification and filtering are illustrated in Figure 7. The output signal which has been preamplified at the microphone 12 is passed to an LSM lowpass filter having a cut- off frequency of 80 Hz, the output signal from the
LSM lowpass filter is passed to a DC amplifier where it is amplified by 10 times. The output signal from this amplifier is passed to an LSM highpass filter having a cut off frequency of 30 Hz and the output signal therefrom is amplified by an AC amplifier by 10 times. The amplified output is passed to a clipper .
As before, the filter 17 of diagrammatic Figure 1 comprises the LSM lowpass filter, DC amplifer and LSM highpass filter and AC amplifier.
Optimising the Signal-to-Noise Ratio
The filtered output .from the previous step is passed to an amplitude clipper module. This module effectively extracts the noise band between selectable amplitude limits and rejects it. The positive and negative parts of the. signal are then "joined up" again and amplified to a constant level.
The sound envelope is generated by passing the signal from the previous stage to an integrated circuit in which the RMS (root mean square) value of the signal is calculated and expressed as a DC value. The time constant of the system is 120 to 250 msecs. This
OMP
process converts the pair of spike signals from the previous step into an "M" shaped envelope in which the first peak corresponds to the first sound and the next peak to the second heart sound. Thi s helps to smooth the heart signal and improves the signal stabi l i ty . Thi s s tep can be om i tted but f al s e triggering is more likely. r
Generating the Trigger Pulses
This stage is illustrated in Figure 8. In a comparable manner to the breathing envelope, the cardiac sound envelope activates a non-retriggerable monostable when the upstroke crosses a preset amplitude limit, set 20% below the peak amplitude level of the envelope. Further smoothing is achieved by specifying the period for which the pulse generator cannot be retriggered using a second monostable module. The refractory period selected is 300 msecs, accommodating heart rates approaching an upper limit of 180/min.
From this step a pulse output is produced which is passed to he logic circuit.
Alternatively this step can be performed with two variable non-retriggerable monostables, the first of which delivers a pulse of 300 msecs duration triggered on the upstroke of the sound envelope and the second monostable delivers a TTL pulse on the upstroke of the first heart pulse.
MOVEMENT SIGNAL
Any movement of the body will produce an audio signal. This audio movement signal is normally in the range of 1 to 4 volts RMS after amplification. Signal levels greater than 5 volts RMS indicate additional noise. Signals greater than 7 volts RMS indicate movement or vocalisation.
The raw sound signal is monitored by an RMS voltage window comparator with a time constant of 2 sees. When the input signal falls outside the 1-5 V RMS window, the output from the comparator goes high for signals > 5 V RMS and low for signals < 1 V RMS. The outputs from the comparator are available as DC levels and also operate appropriately coloured lights automati cally .
The above process has therefore now produced a TTL pulse for each breath and heart beat and also a high DC level which indicates movement. The apparatus includes digital circuitry to analyse these rates of pulses and the trend and to cause an alarm to operate if the rates and trends are outside predetermined limits which may be adjustable for age, weight and other factors.
The apparatus described particularly with regard to Figure 1 is suitable for experimental or hospital use. However, a simplified version of the apparatus
OMPI
may be produced for home use in which expensive components such as the VDU plotter may be deleted, the apparatus si mply produci ng an alarm if predetermined parameters r egardi ng cardi ac and respiratory rate are exceeded. In such a case , the apparatus can be produced more cheaply as the electronic components can be produced in integrated circuit form.
The invention is not restricted to the details of the foregoing example.
OMPI_
Claims
1. A cardio-respiratory monitor apparatus comprising a sound detector for detecting sound from a body, means for passing a signal representing the sound detected to an analyser apparatus, said analyser apparatus including means to distinguish the signal relating to the respiratory function and the signal relating to the cardiac function, and means to monitor these separate signals.
2. Apparatus as claimed in claim 1 in which said signal distinguishing means comprises means to distinguish the frequency of the sound detected by the detector and to separate the respiratory signal and cardiac signal on the basis of frequency.
3. Apparatus as claimed in claim 2 in which the respiratory signal relates to the part of the sound detected in the range of 200 to 950 Hz.
4. Apparatus as claimed in claim 2 or 3 in which the cardiac signal relates ' to the part of the sound detected in the range of 30 to 180 Hz.
5. Apparatus as claimed in any of claims 1 to 4 in which the sound detector comprises a microphone including means whereby in use the microphone is attached to the chest wall of the body.
6. Apparatus as claimed in claim 5 in which the means to attach the microphone to the chest wall- includes means for providing a space between the microphone and the chest wall.
7. Apparatus as claimed in claim 6 in which the means for attaching the microphone to the chest wall comprises adhesive "O" rings.
8. Apparatus as claimed in any of claims 1 to 7 in which the means for monitoring the separate signals includes a phase locking means which will analyse the rate of pulses produced by respiratory and cardiac action and note any missing pulses.
9. A method of monitoring life function comprising detecting sound from a body, analysing a signal derived from the sound detected to provide two output signals, one of which relates to the sound signal relating to respiratory function and the other of which relates to the sound signal relating to the cardiac function, and monitoring these separate signals.
10. A method of determining life function comprising detecting sound from the chest of a human body, determining cardiac function from a first frequency range of detected sound and determining respiratory function fro a second frequency range of detected sound.
11. A method as claimed in claim 10 in which the first frequency range is 30 to 180 Hz and the second frequency range is 200 to 950 Hz.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8230983 | 1982-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1984001705A1 true WO1984001705A1 (en) | 1984-05-10 |
Family
ID=10533932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1983/000276 WO1984001705A1 (en) | 1982-10-29 | 1983-10-31 | Cardio-respiratory monitor apparatus & method |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0124568A1 (en) |
GB (1) | GB2129991A (en) |
WO (1) | WO1984001705A1 (en) |
ZA (1) | ZA838100B (en) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2609623A1 (en) * | 1987-01-15 | 1988-07-22 | Abensour David | Apnoea detector for child |
EP0289682A1 (en) * | 1985-11-08 | 1988-11-09 | GRADIENT "Association régiée par la loi de 1901" Centre de Recherche de Royallieu | Apparatus for monitoring cardiac-respiratory functions |
US4885703A (en) * | 1987-11-04 | 1989-12-05 | Schlumberger Systems, Inc. | 3-D graphics display system using triangle processor pipeline |
US4888712A (en) * | 1987-11-04 | 1989-12-19 | Schlumberger Systems, Inc. | Guardband clipping method and apparatus for 3-D graphics display system |
US4901064A (en) * | 1987-11-04 | 1990-02-13 | Schlumberger Technologies, Inc. | Normal vector shading for 3-D graphics display system |
US4945500A (en) * | 1987-11-04 | 1990-07-31 | Schlumberger Technologies, Inc. | Triangle processor for 3-D graphics display system |
GB2240392A (en) * | 1990-01-17 | 1991-07-31 | Rory Joseph Donnelly | Acoustic monitor for vital functions |
AU700252B2 (en) * | 1994-06-07 | 1998-12-24 | Antarctic Pharma Ab | Composition for dental use comprising krill enzyme |
WO2001022885A1 (en) * | 1999-09-30 | 2001-04-05 | Medtronic Physio-Control Manufacturing Corp. | Method and apparatus for using heart sounds to determine the presence of a pulse |
DE102006017279A1 (en) * | 2006-04-12 | 2007-10-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Automatic detection of hypopneas |
WO2011123071A1 (en) * | 2010-03-31 | 2011-10-06 | Nanyang Technological University | An air conduction sensor and a system and a method for monitoring a health condition |
US8160703B2 (en) | 1999-09-30 | 2012-04-17 | Physio-Control, Inc. | Apparatus, software, and methods for cardiac pulse detection using a piezoelectric sensor |
US8591425B2 (en) | 2002-08-26 | 2013-11-26 | Physio-Control, Inc. | Pulse detection using patient physiological signals |
US9248306B2 (en) | 1999-09-30 | 2016-02-02 | Physio-Control, Inc. | Pulse detection apparatus, software, and methods using patient physiological signals |
US9289167B2 (en) | 1997-04-14 | 2016-03-22 | Masimo Corporation | Signal processing apparatus and method |
RU167630U1 (en) * | 2016-01-20 | 2017-01-10 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный технический университет" | Device for registration and analysis of human respiratory noise |
US9950178B2 (en) | 2001-12-06 | 2018-04-24 | Physio-Control, Inc. | Pulse detection method and apparatus using patient impedance |
CN111856452A (en) * | 2020-05-21 | 2020-10-30 | 重庆邮电大学 | OMP-based static human heartbeat and respiration signal separation and reconstruction method |
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GB2214302A (en) * | 1988-01-11 | 1989-08-31 | Nikolai Sleep Monitoring Clini | An apnoea monitor for use during sleep |
SE9602699D0 (en) * | 1996-07-08 | 1996-07-08 | Siemens Elema Ab | A method and apparatus for determining when a partially or completely collapsed lung has been opened |
GB0118728D0 (en) * | 2001-07-31 | 2001-09-26 | Univ Belfast | Monitoring device |
IL156556A (en) | 2003-06-19 | 2010-02-17 | Eran Schenker | Life signs detector |
US7033323B2 (en) * | 2004-02-04 | 2006-04-25 | Deepbreeze Ltd. | Method and system for analyzing respiratory tract air flow |
DE102007063008A1 (en) * | 2007-12-21 | 2009-06-25 | Kouemou, Guy Leonard, Dr. Ing. | Method and device for cardiovascular and respiratory monitoring using hidden Markov models and neural networks |
EP2437657B1 (en) * | 2009-06-05 | 2018-05-23 | Koninklijke Philips N.V. | Capacitive sensing system |
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Publication number | Priority date | Publication date | Assignee | Title |
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EP0289682A1 (en) * | 1985-11-08 | 1988-11-09 | GRADIENT "Association régiée par la loi de 1901" Centre de Recherche de Royallieu | Apparatus for monitoring cardiac-respiratory functions |
FR2609623A1 (en) * | 1987-01-15 | 1988-07-22 | Abensour David | Apnoea detector for child |
US4885703A (en) * | 1987-11-04 | 1989-12-05 | Schlumberger Systems, Inc. | 3-D graphics display system using triangle processor pipeline |
US4888712A (en) * | 1987-11-04 | 1989-12-19 | Schlumberger Systems, Inc. | Guardband clipping method and apparatus for 3-D graphics display system |
US4901064A (en) * | 1987-11-04 | 1990-02-13 | Schlumberger Technologies, Inc. | Normal vector shading for 3-D graphics display system |
US4945500A (en) * | 1987-11-04 | 1990-07-31 | Schlumberger Technologies, Inc. | Triangle processor for 3-D graphics display system |
GB2240392A (en) * | 1990-01-17 | 1991-07-31 | Rory Joseph Donnelly | Acoustic monitor for vital functions |
AU700252B2 (en) * | 1994-06-07 | 1998-12-24 | Antarctic Pharma Ab | Composition for dental use comprising krill enzyme |
US9289167B2 (en) | 1997-04-14 | 2016-03-22 | Masimo Corporation | Signal processing apparatus and method |
US9981142B2 (en) | 1999-09-30 | 2018-05-29 | Physio-Control, Inc. | Pulse detection apparatus, software, and methods using patient physiological signals |
US9248306B2 (en) | 1999-09-30 | 2016-02-02 | Physio-Control, Inc. | Pulse detection apparatus, software, and methods using patient physiological signals |
US7917209B2 (en) | 1999-09-30 | 2011-03-29 | Physio-Control, Inc. | Pulse detection apparatus, software, and methods using patient physiological signals |
US8744577B2 (en) | 1999-09-30 | 2014-06-03 | Physio-Control, Inc. | Pulse detection apparatus, software, and methods using patient physiological signals |
US8160703B2 (en) | 1999-09-30 | 2012-04-17 | Physio-Control, Inc. | Apparatus, software, and methods for cardiac pulse detection using a piezoelectric sensor |
US8239024B2 (en) | 1999-09-30 | 2012-08-07 | Physio-Control, Inc. | Pulse detection apparatus, software, and methods using patient physiological signals |
US8532766B2 (en) | 1999-09-30 | 2013-09-10 | Physio-Control, Inc. | Pulse detection apparatus, software, and methods using patient physiological signals |
US6440082B1 (en) | 1999-09-30 | 2002-08-27 | Medtronic Physio-Control Manufacturing Corp. | Method and apparatus for using heart sounds to determine the presence of a pulse |
WO2001022885A1 (en) * | 1999-09-30 | 2001-04-05 | Medtronic Physio-Control Manufacturing Corp. | Method and apparatus for using heart sounds to determine the presence of a pulse |
US9950178B2 (en) | 2001-12-06 | 2018-04-24 | Physio-Control, Inc. | Pulse detection method and apparatus using patient impedance |
US11045100B2 (en) | 2002-08-26 | 2021-06-29 | West Affum Holdings Corp. | Pulse detection using patient physiological signals |
US8591425B2 (en) | 2002-08-26 | 2013-11-26 | Physio-Control, Inc. | Pulse detection using patient physiological signals |
US9216001B2 (en) | 2002-08-26 | 2015-12-22 | Physio-Control, Inc. | Pulse detection using patient physiological signals |
US8992432B2 (en) | 2002-08-26 | 2015-03-31 | Physio-Control, Inc. | Pulse detection using patient physiological signals |
US11419508B2 (en) | 2003-09-02 | 2022-08-23 | West Affum Holdings Dac | Pulse detection using patient physiological signals |
DE102006017279A1 (en) * | 2006-04-12 | 2007-10-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Automatic detection of hypopneas |
WO2011123071A1 (en) * | 2010-03-31 | 2011-10-06 | Nanyang Technological University | An air conduction sensor and a system and a method for monitoring a health condition |
RU167630U1 (en) * | 2016-01-20 | 2017-01-10 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный технический университет" | Device for registration and analysis of human respiratory noise |
CN111856452B (en) * | 2020-05-21 | 2022-09-20 | 重庆邮电大学 | OMP-based static human heartbeat and respiration signal separation and reconstruction method |
CN111856452A (en) * | 2020-05-21 | 2020-10-30 | 重庆邮电大学 | OMP-based static human heartbeat and respiration signal separation and reconstruction method |
Also Published As
Publication number | Publication date |
---|---|
GB2129991A (en) | 1984-05-23 |
EP0124568A1 (en) | 1984-11-14 |
ZA838100B (en) | 1984-06-27 |
GB8329057D0 (en) | 1983-11-30 |
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