WO1990000412A1 - Intramedullary catheter - Google Patents
Intramedullary catheter Download PDFInfo
- Publication number
- WO1990000412A1 WO1990000412A1 PCT/US1988/002391 US8802391W WO9000412A1 WO 1990000412 A1 WO1990000412 A1 WO 1990000412A1 US 8802391 W US8802391 W US 8802391W WO 9000412 A1 WO9000412 A1 WO 9000412A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conduit
- bone
- head
- bore
- cavity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Definitions
- This invention relates to a device for delivering fluids to the vascular system through the bone marrow cavity, a method of implanting such a device, and a method of using such a device.
- the device com ⁇ prises an intramedullary catheter which is implanted in a bone and covered by the skin, providing access for the administration of fluids through the bone marrow into the vascular system.
- Intravenous devices are commonly used for the delivery of fluids, such as drugs or the like, directly to the vascular system. Most hospital patients are fitted with an intravenous device to provide the physician with easy access to the vascular system for the administration of such fluids. The advantages of intravenous devices for quickly delivering medication to the vascular system are readily apparent, there are, however, a number of disad ⁇ vantages.
- intravenous devices Perhaps the greatest problem with such intravenous devices is simply the procedure involved in inserting such devices. Often, locating the vein in which such an intravenous device can be placed is difficult, subjecting the patient to a painful ordeal as the doctor or nurse probes the area under the skin in an attempt to find a vein. All of these problems are particularly magnified in those patients requiring long-term (e.g. greater than two weeks) administration of medication.
- One such device is the Hich an Broviac silastic catheter which is tunneled under the skin, usually in the chest, and inserted into a large vein, usually the subclavian vein.
- Other such systems include the Port-a-cath Infus-a-port (sold by Infasaid), and the Mediport (sold by Norfolk) which are essentially cavity structures which are implanted under the skin and have a self-sealing septum. Medication is injected through a needle inserted through the skin and septum into the cavity. A catheter leads from the cavity to the vein to deliver the medication to the vein.
- the intramedullary catheter hereof provides convenient access to the vascular system without the major infection, clotting, cosmetic, and insertion problems associated with intravenous devices and such implant devices.
- the intramedullary catheter of the present invention is particularly appropriate where the patient requires long-term administration of medication.
- the present invention contemplates a device, alternatively known as an intramedullary catheter or osteoport, which is attached to a bone for providing access for fluid delivery to the vascular system.
- the device includes a tubular conduit which is inserted through a bore in the bone in communication with the bone marrow cavity.
- a head is attached to one end of the conduit to lay adjacent the bone such that the sur- rounding skin can be closed about the head.
- the head includes a seal mechanism which overlies the conduit and permits the insertion of a needle through the seal mechanism to deliver the fluid or other medication to the conduit for transport to the bone marrow. It has been found that many medications delivered to the bone marrow are rapidly dispersed throughout the vascular system.
- the present invention also contemplates a method of fluid or drug delivery to the vascular system of a patient which includes such an intramedullary catheter.
- the intramedullary catheter is implanted in a bone with the conduit in communication with the bone marrow cavity by drilling a bore into the bone and inserting the conduit into the bore.
- the bore in the bone is tapped with threads and the conduit has threads along a portion such that the catheter is screwed (threadingly secured) into the bore.
- the drug or other fluid is injected through the overlying skin into the conduit for delivery to the bone marrow and transport to the vascular system.
- the present invention addi ⁇ tionally contemplates a method of implanting a drug delivery device such as the intramedullary catheter of the present invention.
- FIGURE 1 represents a fragmentary anatomical sectional view of the iliac crest with the intramedullary catheter of the present invention implanted therein;
- FIGURE 2 is a sectional view of the intramedullary catheter of the present invention.
- FIGURE 3 is a top plan view of the head of the intra ⁇ medullary catheter taken along line 3-3 of FIGURE 2; and
- FIGURE 4 is an elevational view of the intramedullary catheter of the present invention with the sealing mechanism exploded for clarity.
- FIGURE 1 illustrates an intramedullary catheter 10 implanted in a bone 12 such as the anterior iliac crest, with the skin and surrounding tissue 14 overlying the catheter 10.
- the intramedullary catheter 10 broadly includes an elongated tubular conduit portion 16 and a head portion 18.
- the conduit 16 is elongated and needle-like to define a passage 20.
- the outer portion of the conduit 16 includes a mechanism for attaching the conduit 16 to bone 12, which in the pre ⁇ ferred embodiment comprises the threads 22.
- the distal end of the conduit 16 is simply a flat surface, but in alternative embodiments may com- prise the sharpened point.
- the head 18 comprises an enlarged circular saucer 30 concentrically attached to the conduit 16 and preferably defining a cylindrical cavity 32. Structure defining a truncated cone-shaped bore 34 connects the cavity 32 with the passage 20.
- the outer periphery of the saucer 30 includes a plurality of circumferentially spaced apart notches 36 (see FIGS. 3 and 4).
- a seal mechanism 40 is interfitted into the cavity 32 as shown in FIGURE 2.
- the "seal mechanism includes a silastic self-sealing membrane 42 which is complementally dimensioned for sliding reception into the cavity 32.
- the membrane 42 is slightly enlarged relative to the cavity 32 so that the perimeter of the membrane 42 sealingly engages the internal walls of the saucer 30 defining the cavity 32, causing the central portion of the membrane 42 to out ⁇ wardly bulge as shown in FIGURE 2.
- An annular retaining washer 44 is interfitted in an annular groove in the saucer walls defining the cavity 32. The washer 44 overlys the membrane 42, retaining the membrane 42 in position in the cavity 32.
- the catheter 10 can be implanted in many different bones in the skeletal structure with the iliac crest 12 shown in FIGURE 1 a preferred entry location.
- a small incision in the skin 14 is made in the region of the iliac crest 12 and the iliac crest 12 positively identified through the incision.
- a bore is drilled through the bone 12 into communication with the marrow cavity as shown in FIGURE 1.
- An internal thread is tapped into the iliac crest 12 utilizing a thread size and tap used routinely in orthopedic practice for inserting pins in bones.
- the catheter is inserted through the incision in the skin 14, with the distal end of the conduit 16 disposed in the threaded bore in the iliac crest 12.
- the catheter 10 is then screwed into the iliac crest 12 such that the catheter 10 is secured in the bone 12 by the threads 22.
- a driving tool (not shown) is fitted to the catheter 10 and includes four spaced apart lugs which interfit into the notches 36, such that rotation of the driving tool screws the catheter 10 into the bone 12.
- the head 18 abuts the external surface of the bone 12 and the skin 14 is closed over the head 18.
- the catheter 10 contemplates a fluid delivery method to the vascular system through the bone marrow cavity.
- the term "fluids” is used broadly to include drugs and other medications.
- the region of the skin 14 surrounding the catheter 10 is prepped and the needle on the end of a conventional intra ⁇ venous tubing is inserted through the skin 14 and into the membrane 42.
- the distal tip of the needle is inserted through the membrane 14 and positioned somewhere in the region of the passage 20 proximate the bore 34.
- the needle includes a threaded or luer-type hub that can be connected to a variety of external delivery systems. Normally, the needle is connected by tubing to an infusion bottle.
- the drugs or other fluids are administered through the catheter 10 into the bone marrow cavity. It has been found that where drugs are injected into bone marrow cavity, that the drugs are rapidly absorbed from the marrow cavity. In many instances, the drugs are delivered as rapidly to the vascular system through the marrow cavity as in direct infusion into a vein.
- the catheter 10 and methods of implantation and use offer many advantages over conventional drug delivery procedures. For example, there are no clotting problems in that the catheter 10 is not located in a vein, and similarly, the probability of infection is dimensioned. Once the catheter 10 is inserted, there are no cosmetic disfigurations and little or no chance for occlusion or migration of the catheter 10. The cost of inserting the catheter 10 is minimal, and it can be easily inserted in historically more difficult patients such as infants and geriatrics or other long term care patients. Finally, there is no chance for pneu o- thorax and no chance for leakage of toxic drugs outside of the desired location, as is possible with intravenous devices.
- the catheter 10 and methods of implantation and drug delivery offer a notable advance over the art.
- the catheter and methods of the present invention represent a significant advance for patients requiring long term administration of fluids.
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/008,874 US4772261A (en) | 1987-01-29 | 1987-01-29 | Intramedullary catheter |
KR1019900700502A KR950006144B1 (en) | 1988-07-14 | 1988-07-14 | Intramedullary catheter |
JP1503251A JPH0661357B2 (en) | 1988-07-14 | 1988-07-14 | Intra-barrel catheter |
JP89503251A JPH04500462A (en) | 1988-07-14 | 1988-07-14 | intramural catheter |
AU32171/89A AU625334B2 (en) | 1988-07-14 | 1988-07-14 | Intramedullary catheter |
PCT/US1988/002391 WO1990000412A1 (en) | 1988-07-14 | 1988-07-14 | Intramedullary catheter |
EP89903533A EP0424387B1 (en) | 1988-07-14 | 1988-07-14 | Intramedullary catheter |
DE3851543T DE3851543T2 (en) | 1988-07-14 | 1988-07-14 | MARKET CATHETER. |
CA000577872A CA1324547C (en) | 1988-07-14 | 1988-09-20 | Intramedullary catheter |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1988/002391 WO1990000412A1 (en) | 1988-07-14 | 1988-07-14 | Intramedullary catheter |
CA000577872A CA1324547C (en) | 1988-07-14 | 1988-09-20 | Intramedullary catheter |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1990000412A1 true WO1990000412A1 (en) | 1990-01-25 |
Family
ID=25672122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1988/002391 WO1990000412A1 (en) | 1987-01-29 | 1988-07-14 | Intramedullary catheter |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1990000412A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992013591A2 (en) * | 1991-02-01 | 1992-08-20 | Univ Texas | Improved intramedullary catheter |
US5332398A (en) * | 1992-02-01 | 1994-07-26 | Board Of Regents, The University Of Texas System | Intramedullary catheter |
US6018094A (en) * | 1995-02-06 | 2000-01-25 | Biomedical Enterprises, Inc. | Implant and insert assembly for bone and uses thereof |
US10426940B2 (en) | 2014-11-13 | 2019-10-01 | PAVmed Inc. | Intraosseous infusion ports and methods of use |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2426535A (en) * | 1944-10-21 | 1947-08-26 | Turkel Henry | Infusion and biopsy needle |
US3750667A (en) * | 1972-01-31 | 1973-08-07 | N Pshenichny | Device for intraosseous injection of liquid substances |
EP0103081A2 (en) * | 1982-07-06 | 1984-03-21 | Hti Bio-Products, Inc. | Method of growing cells in vitro |
US4494535A (en) * | 1981-06-24 | 1985-01-22 | Haig Armen C | Hip nail |
EP0134745A1 (en) * | 1983-09-02 | 1985-03-20 | Henri Meriaux | Infusion device |
WO1988006023A1 (en) * | 1987-02-20 | 1988-08-25 | Klaus Draenert | Suction drainage-bone screw |
US4772261A (en) * | 1987-01-29 | 1988-09-20 | Board Of Regents, The University Of Texas System | Intramedullary catheter |
-
1988
- 1988-07-14 WO PCT/US1988/002391 patent/WO1990000412A1/en active IP Right Grant
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2426535A (en) * | 1944-10-21 | 1947-08-26 | Turkel Henry | Infusion and biopsy needle |
US3750667A (en) * | 1972-01-31 | 1973-08-07 | N Pshenichny | Device for intraosseous injection of liquid substances |
US4494535A (en) * | 1981-06-24 | 1985-01-22 | Haig Armen C | Hip nail |
EP0103081A2 (en) * | 1982-07-06 | 1984-03-21 | Hti Bio-Products, Inc. | Method of growing cells in vitro |
EP0134745A1 (en) * | 1983-09-02 | 1985-03-20 | Henri Meriaux | Infusion device |
US4772261A (en) * | 1987-01-29 | 1988-09-20 | Board Of Regents, The University Of Texas System | Intramedullary catheter |
WO1988006023A1 (en) * | 1987-02-20 | 1988-08-25 | Klaus Draenert | Suction drainage-bone screw |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992013591A2 (en) * | 1991-02-01 | 1992-08-20 | Univ Texas | Improved intramedullary catheter |
WO1992013591A3 (en) * | 1991-02-01 | 1992-12-23 | Univ Texas | Improved intramedullary catheter |
AU656367B2 (en) * | 1991-02-01 | 1995-02-02 | Board Of Regents, The University Of Texas System | Improved intramedullary catheter |
US5332398A (en) * | 1992-02-01 | 1994-07-26 | Board Of Regents, The University Of Texas System | Intramedullary catheter |
US6228088B1 (en) | 1992-02-01 | 2001-05-08 | Board Of Regents, The University Of Texas System | Combination drill bit and intrametullary catheter and method of using same |
US6018094A (en) * | 1995-02-06 | 2000-01-25 | Biomedical Enterprises, Inc. | Implant and insert assembly for bone and uses thereof |
US10426940B2 (en) | 2014-11-13 | 2019-10-01 | PAVmed Inc. | Intraosseous infusion ports and methods of use |
US10434296B2 (en) | 2014-11-13 | 2019-10-08 | PAVmed Inc. | Intraosseous infusion ports and methods of use |
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