WO1990006086A1 - Valve device - Google Patents

Valve device Download PDF

Info

Publication number
WO1990006086A1
WO1990006086A1 PCT/AU1989/000511 AU8900511W WO9006086A1 WO 1990006086 A1 WO1990006086 A1 WO 1990006086A1 AU 8900511 W AU8900511 W AU 8900511W WO 9006086 A1 WO9006086 A1 WO 9006086A1
Authority
WO
WIPO (PCT)
Prior art keywords
valve device
inflatable members
branch lines
members
blood vessel
Prior art date
Application number
PCT/AU1989/000511
Other languages
French (fr)
Inventor
Michael Peter Wildon
Original Assignee
Leadon Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leadon Pty Ltd filed Critical Leadon Pty Ltd
Publication of WO1990006086A1 publication Critical patent/WO1990006086A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/1204—Type of occlusion temporary occlusion
    • A61B17/12045—Type of occlusion temporary occlusion double occlusion, e.g. during anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/12127—Double occlusion, e.g. for creating blood-free anastomosis site

Definitions

  • THIS INVENTION relates to a valve device for temporarily blocking a fluid flow line.
  • the invention has been devised particularly, although not exclusively, for use in surgical applications where it is necessary to provide an occlusion in blood vessels such as arteries.
  • occlusions are provided by applying clamps, snares or tapes to the outside of the blood vessels and crimping the lumins of the blood vessels to block blood flow.
  • This procedure has a number of disadvantages, one of which is that it is generally necessary to dissect the blood vessel from its anatomical position in the body of the patient to provide full circumferential access to the blood vessel to allow for the occlusion.
  • the present invention seeks to provide a novel and useful means for providing an occlusion in a fluid flow passage such as a blood vessel.
  • the invention resides in a valve device comprising a pair of inflatable members, and a delivery line one end of which is in communication with said inflatable members and the other end of which is connectable to a source of inflation fluid.
  • a delivery line one end of which is in communication with said inflatable members and the other end of which is connectable to a source of inflation fluid.
  • said one end of the delivery line includes two branch lines each of which is connected to a respective one of the inflatable members.
  • said branch lines are substantially rigid so as to maintain the inflatable members in spaced relationship while being sufficiently resilient to allow deflection for insertion of the inflatable members into, and removal of the inflation members from, a fluid flow line.
  • branch lines are arranged in a substantially V formation when said inflation members are in said spaced relationship.
  • branch lines can resiliently deflect towards eachother into substantially side-by-side relationship.
  • branch lines are of different lengths whereby said inflatable members are offset from one another when said branch lines are in said side-by-side relationship.
  • said inflatable members comprise balloons fitted onto the ends of the branch line.
  • the balloons are made of latex material.
  • said delivery line is flexible.
  • the inflation fluid is a liquid.
  • the liquid preferably comprises an isotonic liquid.
  • the source of inflation fluid comprises a syringe having inflation fluid in its barrel.
  • Fig. 1 is a schematic perspective view (on an enlarged scale) of a valve device according to the embodiment
  • Fig. 2 is a fragmentary view of the valve device showing the branch lines and inflatable members in spaced relationship;
  • Fig. 3 is a view similar to Fig. 2 except that the branch lines are shown in side-by-side relation;
  • Fig. 4 is a schematic view illustrating the valve device being inserted into a blood vessel through a surgical incision in the vessel;
  • Fig. 5 is a schematic view illustrating the valve device in position in the blood vessel prior to inflation of the inflatable members
  • Fig. 6 is a view similar to Fig. 5 except that the inflatable members are shown in an inflated condition so as to provide an occlusion in the blood vessel;
  • Fig. 7 is a schematic view illustrating the valve device being withdrawn from the blood vessel towards the end of a grafting procedure.
  • the embodiment shown in the drawings is directed to a valve device for surgical applications to provide an occlusion in a blood vessel such as an artery, particularly for bypass grafting or vessel repair.
  • the valve device comprises a flexible fluid delivery line 11 having a pair of branch lines 13 at one of its ends.
  • An inflatable member 15 in the form of a latex balloon is fitted onto the outer end of each branch line.
  • the branch lines 13 are arranged in a V formation.
  • the branch lines 13 are formed of resiliently flexible tube material which normally maintains the inflatable in spaced relationship (as shown in Fig. 2) but which can resiliently deflect to allow the branch lines 13 to assume a position in which they are in side-by-side relation (as shown in Fig. 3) . So that the inflatable members are offset from eachother when the branch lines 13 are in side-by-side relation (as best seen in Fig. 3), the branch lines are different from eachother in length.
  • the end of the fluid delivery line 11 opposite the branch liens 13 is adapted for connection to a source 17 of inflation fluid such as a syringe containing such fluid.
  • a reference mark 19 is provided on the syringe 17 and the position of the syringe is aligned with the reference mark when the inflatable members 15 are in the deflated condition.
  • the inflation fluid comprises an isotonic liquid.
  • valve device Operation of the valve device will now be described in relation to a surgical operation which involves grafting a graft vessel 20 onto an existing blood vessel 21, as illustrated in in Figs. 4 to 7 of the accompanying drawings (where both the blood vessel and graft vessel are depicted by broken lines) .
  • a surgical incision 23 is formed in the side wall of the blood vessel 21 and the branch lines 13 of the valve device are inserted into the lumen of the blood vessel 21 such that one inflatable member 15 is disposed to each side of, and spaced inwardly from the incision 23, as illustrated in Figs.
  • the syringe 17 is then operated to introduce inflation fluid into the inflatable members 15 via the delivery line 11 and the branch lines 13.
  • the inflatable members 15 expand and sealingly engage against the inner wall of the blood vessel 21 and block blood flow therealong, as illustrated in Fig. 6 of the drawings.
  • the inflatable members 15 are in fluid communication with eachother by way of the branch lines and the delivery line, the pressure within the chambers can equalise. This allows the inflatable members to accommodate situations where the vessel lumen differs in cross-section size on opposed sides of the surgical incision.
  • the graft vessel 20 can be sutured to the blood vessel 21 in conventional manner.
  • the final few sutures are, however, left loose so that the occlusion can be removed.
  • the plunger of the syringe is then retracted to the reference mark 19 so as to draw the inflation fluid back into the syringe and so deflate the inflatable members.
  • the inflatable members can be removed from the blood vessel by gently pulling on the delivery line.
  • the branch lines leave the blood vessel 21 they are urged towards eachother to assume said side-by-side relation for convenient passage through the loose sutures. Because the inflatable members are offset from eachother at this stage, one follows the other through the loose sutures without damaging the sutures or the grafted vessels.
  • the present invention enables a temporary occlusion to be established in a blood vessel in a relatively convenient and easy manne .
  • valve device may have applications in fields other than formation of occlusions in blood vessels during surgical procedures.

Abstract

A valve device for providing an occlusion in a blood vessel to restrict or prevent blood flow to a site where surgery is being performed. The valve device comprising a delivery line (11) having two resiliently flexible branch lines (13) at one end. An inflatable member (15) is fitted onto the outer end of each branch line. The other end of the delivery line (11) is connected to a source (17) of inflation fluid for inflating the inflatable members. The inflatable members can be inserted into a blood vessel through a surgical incision in the vessel and on inflation the inflatable members sealingly engage the interior surface of the blood vessel to establish an occlusion on each side of the incision.

Description

"Valve Device"
FIELD OF THE INVENTION
THIS INVENTION relates to a valve device for temporarily blocking a fluid flow line.
BACKGROUND TO THE INVENTION
The invention has been devised particularly, although not exclusively, for use in surgical applications where it is necessary to provide an occlusion in blood vessels such as arteries.
Where a patient is undergoing surgery and it is necessary to restrict or prevent blood flow to the surgical site, it is usual to provide occlusions in blood vessels in the locality of the site. Conventionally, the occlusions are provided by applying clamps, snares or tapes to the outside of the blood vessels and crimping the lumins of the blood vessels to block blood flow. This procedure has a number of disadvantages, one of which is that it is generally necessary to dissect the blood vessel from its anatomical position in the body of the patient to provide full circumferential access to the blood vessel to allow for the occlusion.
SUMMARY OF THE INVENTION
The present invention seeks to provide a novel and useful means for providing an occlusion in a fluid flow passage such as a blood vessel.
In one form the invention resides in a valve device comprising a pair of inflatable members, and a delivery line one end of which is in communication with said inflatable members and the other end of which is connectable to a source of inflation fluid. Preferably said one end of the delivery line includes two branch lines each of which is connected to a respective one of the inflatable members.
Preferably, said branch lines are substantially rigid so as to maintain the inflatable members in spaced relationship while being sufficiently resilient to allow deflection for insertion of the inflatable members into, and removal of the inflation members from, a fluid flow line.
Preferably said branch lines are arranged in a substantially V formation when said inflation members are in said spaced relationship.
Preferably said branch lines can resiliently deflect towards eachother into substantially side-by-side relationship.
Preferably said branch lines are of different lengths whereby said inflatable members are offset from one another when said branch lines are in said side-by-side relationship.
Preferably, said inflatable members comprise balloons fitted onto the ends of the branch line. Conveniently, the balloons are made of latex material.
Preferably, said delivery line is flexible.
Preferably, the inflation fluid is a liquid. Where the valve apparatus is to be used in surgical applications, the liquid preferably comprises an isotonic liquid.
Preferably, the source of inflation fluid comprises a syringe having inflation fluid in its barrel. BRIEF DESCRIPTION OF THE DRAWINGS
The invention will be better understood by reference to the following description of specific embodiment thereof and shown in the accompanying drawings in which:
Fig. 1 is a schematic perspective view (on an enlarged scale) of a valve device according to the embodiment;
Fig. 2 is a fragmentary view of the valve device showing the branch lines and inflatable members in spaced relationship;
Fig. 3 is a view similar to Fig. 2 except that the branch lines are shown in side-by-side relation;
Fig. 4 is a schematic view illustrating the valve device being inserted into a blood vessel through a surgical incision in the vessel;
Fig. 5 is a schematic view illustrating the valve device in position in the blood vessel prior to inflation of the inflatable members;
Fig. 6 is a view similar to Fig. 5 except that the inflatable members are shown in an inflated condition so as to provide an occlusion in the blood vessel; and
Fig. 7 is a schematic view illustrating the valve device being withdrawn from the blood vessel towards the end of a grafting procedure.
DESCRIPTION OF PREFERRED EMBODIMENT
The embodiment shown in the drawings is directed to a valve device for surgical applications to provide an occlusion in a blood vessel such as an artery, particularly for bypass grafting or vessel repair.
The valve device comprises a flexible fluid delivery line 11 having a pair of branch lines 13 at one of its ends. An inflatable member 15 in the form of a latex balloon is fitted onto the outer end of each branch line.
The branch lines 13 are arranged in a V formation. The branch lines 13 are formed of resiliently flexible tube material which normally maintains the inflatable in spaced relationship (as shown in Fig. 2) but which can resiliently deflect to allow the branch lines 13 to assume a position in which they are in side-by-side relation (as shown in Fig. 3) . So that the inflatable members are offset from eachother when the branch lines 13 are in side-by-side relation (as best seen in Fig. 3), the branch lines are different from eachother in length.
The end of the fluid delivery line 11 opposite the branch liens 13 is adapted for connection to a source 17 of inflation fluid such as a syringe containing such fluid. A reference mark 19 is provided on the syringe 17 and the position of the syringe is aligned with the reference mark when the inflatable members 15 are in the deflated condition. In this embodiment the inflation fluid comprises an isotonic liquid.
Operation of the valve device will now be described in relation to a surgical operation which involves grafting a graft vessel 20 onto an existing blood vessel 21, as illustrated in in Figs. 4 to 7 of the accompanying drawings (where both the blood vessel and graft vessel are depicted by broken lines) . During the surgical operation, it is necessary to provide an occlusion in the blood vessel 21 and the device according to the embodiment can be used to provide such occlusion. During the procedure, a surgical incision 23 is formed in the side wall of the blood vessel 21 and the branch lines 13 of the valve device are inserted into the lumen of the blood vessel 21 such that one inflatable member 15 is disposed to each side of, and spaced inwardly from the incision 23, as illustrated in Figs. 4 and 5 of the drawings. The syringe 17 is then operated to introduce inflation fluid into the inflatable members 15 via the delivery line 11 and the branch lines 13. The inflatable members 15 expand and sealingly engage against the inner wall of the blood vessel 21 and block blood flow therealong, as illustrated in Fig. 6 of the drawings.
Because the inflatable members 15 are in fluid communication with eachother by way of the branch lines and the delivery line, the pressure within the chambers can equalise. This allows the inflatable members to accommodate situations where the vessel lumen differs in cross-section size on opposed sides of the surgical incision.
Once the occlusion has been established in the blood vessel, the graft vessel 20 can be sutured to the blood vessel 21 in conventional manner. The final few sutures are, however, left loose so that the occlusion can be removed. The plunger of the syringe is then retracted to the reference mark 19 so as to draw the inflation fluid back into the syringe and so deflate the inflatable members. Following their deflation, the inflatable members can be removed from the blood vessel by gently pulling on the delivery line. As the branch lines leave the blood vessel 21 they are urged towards eachother to assume said side-by-side relation for convenient passage through the loose sutures. Because the inflatable members are offset from eachother at this stage, one follows the other through the loose sutures without damaging the sutures or the grafted vessels. When the valve device has been removed from the surgical site, the loose sutures can be pulled tight and tied. From the foregoing it is evident that the present invention enables a temporary occlusion to be established in a blood vessel in a relatively convenient and easy manne .
Although the invention has been described with reference to one specific embodiment it should be appreciated that it is not limited to such embodiment and that the valve device may have applications in fields other than formation of occlusions in blood vessels during surgical procedures.

Claims

THE CLAIMS defining the invention are as follows:-
1. A valve device comprising a pair of inflatable members, and a delivery line one end of which is in communication with said inflatable members and the other end of which is connectable to a source of inflation fluid.
2. A valve device according to claim 1 wherein said one end of the delivery line includes two branch lines each of which is connected to a respective one of the inflatable members.
3. A valve device according to claim 2 wherein said branch lines are substantially rigid so as to maintain the inflatable members in spaced relationship while being sufficiently resilient to allow deflection for insertion of the inflatable members into, and removal of the inflation members from, a fluid flow line.
4. A valve device according to claim 2 or 3 wherein said branch lines are arranged in a substantially V formation when said inflation members are in said spaced relationship.
5. A valve device according to claim 4 wherein said branch lines can resiliently deflect towards eachother into substantially side-by-side relationship.
6. A valve device according to claim 5 wherein said branch lines are of different lengths whereby said inflatable members are offset from one another when said branch lines are in said side-by-side relationship.
7. A valve device according to any one of the preceding claims wherein said inflatable members comprise balloons fitted onto the ends of the branch line.
8. A valve device according to any one of the preceding claims wherein said delivery line is flexible.
9. A valve device according to any one of the preceding claims wherein the source of inflation fluid comprises a syringe having inflation fluid in its barrel.
10. A valve device substantially as herein described with reference to the accompanying drawings.
PCT/AU1989/000511 1988-11-25 1989-11-24 Valve device WO1990006086A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPJ1682 1988-11-25
AUPJ168288 1988-11-25

Publications (1)

Publication Number Publication Date
WO1990006086A1 true WO1990006086A1 (en) 1990-06-14

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1989/000511 WO1990006086A1 (en) 1988-11-25 1989-11-24 Valve device

Country Status (2)

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CA (1) CA2003826A1 (en)
WO (1) WO1990006086A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000025851A1 (en) * 1998-11-02 2000-05-11 Pro-Med Technology Consult Medizinisch-Technische Geräte Gmbh End piece for a catheter or the like, perfusion catheter and perfusion catheter systems
EP1022033A1 (en) * 1998-11-02 2000-07-26 Pro-Med Technology Consult medizinisch-technische Geräte GmbH Two vessel segments interconnecting catheter
EP1339445A2 (en) * 2000-10-27 2003-09-03 Pulmonx Methods and devices for obstructing and aspirating lung tissue segments
WO2015107434A1 (en) * 2014-01-15 2015-07-23 Jacques Seguin Apparatus using branched balloon for treating pulmonary arterial hypertension
US9421017B2 (en) 2014-01-15 2016-08-23 Jacques Seguin Methods and apparatus using branched balloon for treating pulmonary arterial hypertension
US9427236B2 (en) 2014-01-31 2016-08-30 Jacques Seguin Methods and apparatus using an anchored balloon for treating pulmonary arterial hypertension
US9801989B2 (en) 2014-06-19 2017-10-31 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US9987153B2 (en) 2010-06-08 2018-06-05 The Regents Of The University Of Minnesota Vascular elastance
US10350397B2 (en) 2010-11-22 2019-07-16 Aria Cv, Inc. System and method for reducing pulsatile pressure
US11141581B2 (en) 2019-09-06 2021-10-12 Aria Cv, Inc. Diffusion and infusion resistant implantable devices for reducing pulsatile pressure
US11331105B2 (en) 2016-10-19 2022-05-17 Aria Cv, Inc. Diffusion resistant implantable devices for reducing pulsatile pressure

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US2493326A (en) * 1949-03-01 1950-01-03 John H Trinder Tampon for control of intractable nasal hemorrhages
US3411506A (en) * 1966-04-11 1968-11-19 Velasco Adolfo Guevara Method and apparatus for hemostasis
GB1333096A (en) * 1969-11-21 1973-10-10 Hunter J A Restriction or occlusion of blood vessels
US3850176A (en) * 1972-02-07 1974-11-26 G Gottschalk Nasal tampon
US4230119A (en) * 1978-12-01 1980-10-28 Medical Engineering Corp. Micro-hemostat
AU517687B2 (en) * 1977-08-03 1981-08-20 The Kendall Company Catheter
EP0064653A1 (en) * 1981-05-12 1982-11-17 MANIBS R. Mannesmann GmbH & ibs Nagel GmbH & Co. KG. Device for closing gas conduits
US4395806A (en) * 1980-05-08 1983-08-02 Sorenson Research Co., Inc. Method of manufacturing a detachable balloon catheter assembly
US4404971A (en) * 1981-04-03 1983-09-20 Leveen Harry H Dual balloon catheter

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2493326A (en) * 1949-03-01 1950-01-03 John H Trinder Tampon for control of intractable nasal hemorrhages
US3411506A (en) * 1966-04-11 1968-11-19 Velasco Adolfo Guevara Method and apparatus for hemostasis
GB1333096A (en) * 1969-11-21 1973-10-10 Hunter J A Restriction or occlusion of blood vessels
US3850176A (en) * 1972-02-07 1974-11-26 G Gottschalk Nasal tampon
AU517687B2 (en) * 1977-08-03 1981-08-20 The Kendall Company Catheter
US4230119A (en) * 1978-12-01 1980-10-28 Medical Engineering Corp. Micro-hemostat
US4395806A (en) * 1980-05-08 1983-08-02 Sorenson Research Co., Inc. Method of manufacturing a detachable balloon catheter assembly
US4404971A (en) * 1981-04-03 1983-09-20 Leveen Harry H Dual balloon catheter
EP0064653A1 (en) * 1981-05-12 1982-11-17 MANIBS R. Mannesmann GmbH & ibs Nagel GmbH & Co. KG. Device for closing gas conduits

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000025851A1 (en) * 1998-11-02 2000-05-11 Pro-Med Technology Consult Medizinisch-Technische Geräte Gmbh End piece for a catheter or the like, perfusion catheter and perfusion catheter systems
EP1022033A1 (en) * 1998-11-02 2000-07-26 Pro-Med Technology Consult medizinisch-technische Geräte GmbH Two vessel segments interconnecting catheter
EP1339445A2 (en) * 2000-10-27 2003-09-03 Pulmonx Methods and devices for obstructing and aspirating lung tissue segments
EP1339445A4 (en) * 2000-10-27 2004-07-14 Pulmonx Methods and devices for obstructing and aspirating lung tissue segments
US6997918B2 (en) 2000-10-27 2006-02-14 Pulmonx Methods and devices for obstructing and aspirating lung tissue segments
US9987153B2 (en) 2010-06-08 2018-06-05 The Regents Of The University Of Minnesota Vascular elastance
US11583420B2 (en) 2010-06-08 2023-02-21 Regents Of The University Of Minnesota Vascular elastance
US10617538B2 (en) 2010-06-08 2020-04-14 Regents Of The University Of Minnesota Vascular elastance
US11938291B2 (en) 2010-11-22 2024-03-26 Aria Cv, Inc. System and method for reducing pulsatile pressure
US11406803B2 (en) 2010-11-22 2022-08-09 Aria Cv, Inc. System and method for reducing pulsatile pressure
US10702682B2 (en) 2010-11-22 2020-07-07 Aria Cv, Inc. System and method for reducing pulsatile pressure
US10350397B2 (en) 2010-11-22 2019-07-16 Aria Cv, Inc. System and method for reducing pulsatile pressure
US10751519B2 (en) 2010-11-22 2020-08-25 Aria Cv, Inc. System and method for reducing pulsatile pressure
WO2015107434A1 (en) * 2014-01-15 2015-07-23 Jacques Seguin Apparatus using branched balloon for treating pulmonary arterial hypertension
US9421017B2 (en) 2014-01-15 2016-08-23 Jacques Seguin Methods and apparatus using branched balloon for treating pulmonary arterial hypertension
US9427236B2 (en) 2014-01-31 2016-08-30 Jacques Seguin Methods and apparatus using an anchored balloon for treating pulmonary arterial hypertension
US10682448B2 (en) 2014-06-19 2020-06-16 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US9801989B2 (en) 2014-06-19 2017-10-31 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US11511089B2 (en) 2014-06-19 2022-11-29 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US11331105B2 (en) 2016-10-19 2022-05-17 Aria Cv, Inc. Diffusion resistant implantable devices for reducing pulsatile pressure
US11141581B2 (en) 2019-09-06 2021-10-12 Aria Cv, Inc. Diffusion and infusion resistant implantable devices for reducing pulsatile pressure
US11833343B2 (en) 2019-09-06 2023-12-05 Aria Cv, Inc. Diffusion and infusion resistant implantable devices for reducing pulsatile pressure

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