WO1992000119A1 - Method and device for treating epilepsy - Google Patents
Method and device for treating epilepsy Download PDFInfo
- Publication number
- WO1992000119A1 WO1992000119A1 PCT/BE1991/000043 BE9100043W WO9200119A1 WO 1992000119 A1 WO1992000119 A1 WO 1992000119A1 BE 9100043 W BE9100043 W BE 9100043W WO 9200119 A1 WO9200119 A1 WO 9200119A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pulses
- electrodes
- positive
- frequency
- duration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36064—Epilepsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/3615—Intensity
- A61N1/36153—Voltage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
Definitions
- the present invention relates to a method and a device for the treatment of epilepsy by using electrodes producing electrical pulses applied to the patient's head.
- the impulses can be positive or negative. According to a particular embodiment of the invention, the pulses will preferably be positive.
- the pulses can also be multiple pulses made up of different frequencies, used either sequentially or alternately, or even using a carrier frequency or a frequency modulated by another frequency.
- an essential rectangular, negative wave is superimposed on a generally positive pulse, so that the energy of the negative part is essentially equivalent to the energy of the positive part. Any phenomenon of electrolysis can be controlled.
- electrodes are applied which produce electrical pulses of low frequency between the above-mentioned values and of power which can vary from 1 to 170 V (peak voltage).
- the duration of a pulse can vary from 2.5 ms to 0.025 ms, preferably from 0.2 to 0.30 ms. A value of 0.25 ms (+/- 0.1) was advantageously applied.
- the patients Preferably use three electrodes, for example a positive front electrode and 2 negative electrodes at the base of the neck. It is also possible to use more than three electrodes.
- the patients are treated in two successive phases of approximately 10 minutes, the frequencies being 1.5 Hz or approximately 1.5 Hz for the first phase which may last 10 minutes and 28 Hz or approximately 28 Hz for the second phase of the same duration.
- the powers must be adapted to each particular case and can vary from 1 to 170 Volts.
- the generator used for implementing the invention can be easily designed by those skilled in the art.
- the apparatus for implementing the invention can operate on a single protected 6-volt battery.
- This battery is rechargeable on the mains, with protection preventing any use on the mains.
- the device comprises two mono Jack inputs, 2 potentiometers, one of which is provided with a -4-
- the device can be fitted with a charge indicator. It switches off when the battery voltage drops to 4.5 volts, to prevent premature deterioration of the battery.
- the voltmeter and the ammeter indicate: the peak values.
- the device is preferably compact and transportable.
- FIG. 1 illustrates the shape of the empty and loaded pulse.
- FIG. 2 illustrates the invention by way of example. References in the figure refer to the following:
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO92920780A NO920780L (en) | 1990-06-28 | 1992-02-27 | PROCEDURE AND DEVICE FOR TREATMENT OF EPILEPSY |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE9000660 | 1990-06-28 | ||
BE9000660 | 1990-06-28 | ||
BE9100054 | 1991-01-23 | ||
BE9100054 | 1991-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992000119A1 true WO1992000119A1 (en) | 1992-01-09 |
Family
ID=25662538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/BE1991/000043 WO1992000119A1 (en) | 1990-06-28 | 1991-06-27 | Method and device for treating epilepsy |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0489879A1 (en) |
JP (1) | JPH05502608A (en) |
AU (1) | AU8095491A (en) |
CA (1) | CA2065388A1 (en) |
IE (1) | IE912227A1 (en) |
IL (1) | IL98656A0 (en) |
MX (1) | MX9100005A (en) |
NO (1) | NO920780L (en) |
PT (1) | PT98122A (en) |
WO (1) | WO1992000119A1 (en) |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5752979A (en) * | 1996-11-01 | 1998-05-19 | Medtronic, Inc. | Method of controlling epilepsy by brain stimulation |
WO2004060481A1 (en) * | 2003-01-03 | 2004-07-22 | Groenemeyer Dietrich H W | Electric trainer |
US7676263B2 (en) | 2006-06-23 | 2010-03-09 | Neurovista Corporation | Minimally invasive system for selecting patient-specific therapy parameters |
US7747325B2 (en) | 1998-08-05 | 2010-06-29 | Neurovista Corporation | Systems and methods for monitoring a patient's neurological disease state |
US7853329B2 (en) | 1998-08-05 | 2010-12-14 | Neurovista Corporation | Monitoring efficacy of neural modulation therapy |
US8036736B2 (en) | 2007-03-21 | 2011-10-11 | Neuro Vista Corporation | Implantable systems and methods for identifying a contra-ictal condition in a subject |
US8295934B2 (en) | 2006-11-14 | 2012-10-23 | Neurovista Corporation | Systems and methods of reducing artifact in neurological stimulation systems |
US8588933B2 (en) | 2009-01-09 | 2013-11-19 | Cyberonics, Inc. | Medical lead termination sleeve for implantable medical devices |
US8725243B2 (en) | 2005-12-28 | 2014-05-13 | Cyberonics, Inc. | Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders |
US8762065B2 (en) | 1998-08-05 | 2014-06-24 | Cyberonics, Inc. | Closed-loop feedback-driven neuromodulation |
US8786624B2 (en) | 2009-06-02 | 2014-07-22 | Cyberonics, Inc. | Processing for multi-channel signals |
US8849390B2 (en) | 2008-12-29 | 2014-09-30 | Cyberonics, Inc. | Processing for multi-channel signals |
US8868172B2 (en) | 2005-12-28 | 2014-10-21 | Cyberonics, Inc. | Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders |
US9042988B2 (en) | 1998-08-05 | 2015-05-26 | Cyberonics, Inc. | Closed-loop vagus nerve stimulation |
US9259591B2 (en) | 2007-12-28 | 2016-02-16 | Cyberonics, Inc. | Housing for an implantable medical device |
US9375573B2 (en) | 1998-08-05 | 2016-06-28 | Cyberonics, Inc. | Systems and methods for monitoring a patient's neurological disease state |
US9415222B2 (en) | 1998-08-05 | 2016-08-16 | Cyberonics, Inc. | Monitoring an epilepsy disease state with a supervisory module |
US9421373B2 (en) | 1998-08-05 | 2016-08-23 | Cyberonics, Inc. | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US9622675B2 (en) | 2007-01-25 | 2017-04-18 | Cyberonics, Inc. | Communication error alerting in an epilepsy monitoring system |
US9643019B2 (en) | 2010-02-12 | 2017-05-09 | Cyberonics, Inc. | Neurological monitoring and alerts |
US9788744B2 (en) | 2007-07-27 | 2017-10-17 | Cyberonics, Inc. | Systems for monitoring brain activity and patient advisory device |
US9898656B2 (en) | 2007-01-25 | 2018-02-20 | Cyberonics, Inc. | Systems and methods for identifying a contra-ictal condition in a subject |
US11406317B2 (en) | 2007-12-28 | 2022-08-09 | Livanova Usa, Inc. | Method for detecting neurological and clinical manifestations of a seizure |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3918461A (en) * | 1974-01-31 | 1975-11-11 | Irving S Cooper | Method for electrically stimulating the human brain |
WO1985001213A1 (en) * | 1983-09-14 | 1985-03-28 | Jacob Zabara | Neurocybernetic prosthesis |
WO1987000063A1 (en) * | 1984-06-29 | 1987-01-15 | Zion Educational Foundation | Method of treatment with transcranially applied electrical signals |
WO1987007511A2 (en) * | 1986-06-16 | 1987-12-17 | Zion Educational Foundation | Method and apparatus for delivering a prescriptive electrical signal |
WO1990009811A1 (en) * | 1989-03-04 | 1990-09-07 | Tony Matthews | Electro-therapy apparatus |
-
1991
- 1991-06-26 IE IE222791A patent/IE912227A1/en unknown
- 1991-06-27 EP EP91910970A patent/EP0489879A1/en not_active Withdrawn
- 1991-06-27 JP JP3510685A patent/JPH05502608A/en active Pending
- 1991-06-27 IL IL98656A patent/IL98656A0/en unknown
- 1991-06-27 WO PCT/BE1991/000043 patent/WO1992000119A1/en not_active Application Discontinuation
- 1991-06-27 AU AU80954/91A patent/AU8095491A/en not_active Abandoned
- 1991-06-27 PT PT98122A patent/PT98122A/en not_active Application Discontinuation
- 1991-06-27 CA CA002065388A patent/CA2065388A1/en not_active Abandoned
- 1991-07-04 MX MX919100005A patent/MX9100005A/en unknown
-
1992
- 1992-02-27 NO NO92920780A patent/NO920780L/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3918461A (en) * | 1974-01-31 | 1975-11-11 | Irving S Cooper | Method for electrically stimulating the human brain |
WO1985001213A1 (en) * | 1983-09-14 | 1985-03-28 | Jacob Zabara | Neurocybernetic prosthesis |
WO1987000063A1 (en) * | 1984-06-29 | 1987-01-15 | Zion Educational Foundation | Method of treatment with transcranially applied electrical signals |
WO1987007511A2 (en) * | 1986-06-16 | 1987-12-17 | Zion Educational Foundation | Method and apparatus for delivering a prescriptive electrical signal |
WO1990009811A1 (en) * | 1989-03-04 | 1990-09-07 | Tony Matthews | Electro-therapy apparatus |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5752979A (en) * | 1996-11-01 | 1998-05-19 | Medtronic, Inc. | Method of controlling epilepsy by brain stimulation |
US9415222B2 (en) | 1998-08-05 | 2016-08-16 | Cyberonics, Inc. | Monitoring an epilepsy disease state with a supervisory module |
US9421373B2 (en) | 1998-08-05 | 2016-08-23 | Cyberonics, Inc. | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US7747325B2 (en) | 1998-08-05 | 2010-06-29 | Neurovista Corporation | Systems and methods for monitoring a patient's neurological disease state |
US7853329B2 (en) | 1998-08-05 | 2010-12-14 | Neurovista Corporation | Monitoring efficacy of neural modulation therapy |
US7930035B2 (en) | 1998-08-05 | 2011-04-19 | Neurovista Corporation | Providing output indicative of subject's disease state |
US9375573B2 (en) | 1998-08-05 | 2016-06-28 | Cyberonics, Inc. | Systems and methods for monitoring a patient's neurological disease state |
US9320900B2 (en) | 1998-08-05 | 2016-04-26 | Cyberonics, Inc. | Methods and systems for determining subject-specific parameters for a neuromodulation therapy |
US9113801B2 (en) | 1998-08-05 | 2015-08-25 | Cyberonics, Inc. | Methods and systems for continuous EEG monitoring |
US9042988B2 (en) | 1998-08-05 | 2015-05-26 | Cyberonics, Inc. | Closed-loop vagus nerve stimulation |
US8762065B2 (en) | 1998-08-05 | 2014-06-24 | Cyberonics, Inc. | Closed-loop feedback-driven neuromodulation |
US8781597B2 (en) | 1998-08-05 | 2014-07-15 | Cyberonics, Inc. | Systems for monitoring a patient's neurological disease state |
WO2004060481A1 (en) * | 2003-01-03 | 2004-07-22 | Groenemeyer Dietrich H W | Electric trainer |
US8868172B2 (en) | 2005-12-28 | 2014-10-21 | Cyberonics, Inc. | Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders |
US8725243B2 (en) | 2005-12-28 | 2014-05-13 | Cyberonics, Inc. | Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders |
US9044188B2 (en) | 2005-12-28 | 2015-06-02 | Cyberonics, Inc. | Methods and systems for managing epilepsy and other neurological disorders |
US9592004B2 (en) | 2005-12-28 | 2017-03-14 | Cyberonics, Inc. | Methods and systems for managing epilepsy and other neurological disorders |
US9480845B2 (en) | 2006-06-23 | 2016-11-01 | Cyberonics, Inc. | Nerve stimulation device with a wearable loop antenna |
US7676263B2 (en) | 2006-06-23 | 2010-03-09 | Neurovista Corporation | Minimally invasive system for selecting patient-specific therapy parameters |
US8295934B2 (en) | 2006-11-14 | 2012-10-23 | Neurovista Corporation | Systems and methods of reducing artifact in neurological stimulation systems |
US8855775B2 (en) | 2006-11-14 | 2014-10-07 | Cyberonics, Inc. | Systems and methods of reducing artifact in neurological stimulation systems |
US9898656B2 (en) | 2007-01-25 | 2018-02-20 | Cyberonics, Inc. | Systems and methods for identifying a contra-ictal condition in a subject |
US9622675B2 (en) | 2007-01-25 | 2017-04-18 | Cyberonics, Inc. | Communication error alerting in an epilepsy monitoring system |
US8036736B2 (en) | 2007-03-21 | 2011-10-11 | Neuro Vista Corporation | Implantable systems and methods for identifying a contra-ictal condition in a subject |
US8543199B2 (en) | 2007-03-21 | 2013-09-24 | Cyberonics, Inc. | Implantable systems and methods for identifying a contra-ictal condition in a subject |
US9445730B2 (en) | 2007-03-21 | 2016-09-20 | Cyberonics, Inc. | Implantable systems and methods for identifying a contra-ictal condition in a subject |
US9788744B2 (en) | 2007-07-27 | 2017-10-17 | Cyberonics, Inc. | Systems for monitoring brain activity and patient advisory device |
US9259591B2 (en) | 2007-12-28 | 2016-02-16 | Cyberonics, Inc. | Housing for an implantable medical device |
US11406317B2 (en) | 2007-12-28 | 2022-08-09 | Livanova Usa, Inc. | Method for detecting neurological and clinical manifestations of a seizure |
US8849390B2 (en) | 2008-12-29 | 2014-09-30 | Cyberonics, Inc. | Processing for multi-channel signals |
US9289595B2 (en) | 2009-01-09 | 2016-03-22 | Cyberonics, Inc. | Medical lead termination sleeve for implantable medical devices |
US8588933B2 (en) | 2009-01-09 | 2013-11-19 | Cyberonics, Inc. | Medical lead termination sleeve for implantable medical devices |
US8786624B2 (en) | 2009-06-02 | 2014-07-22 | Cyberonics, Inc. | Processing for multi-channel signals |
US9643019B2 (en) | 2010-02-12 | 2017-05-09 | Cyberonics, Inc. | Neurological monitoring and alerts |
Also Published As
Publication number | Publication date |
---|---|
JPH05502608A (en) | 1993-05-13 |
IE912227A1 (en) | 1992-01-01 |
AU8095491A (en) | 1992-01-23 |
NO920780D0 (en) | 1992-02-27 |
MX9100005A (en) | 1992-02-03 |
PT98122A (en) | 1993-09-30 |
IL98656A0 (en) | 1992-07-15 |
EP0489879A1 (en) | 1992-06-17 |
NO920780L (en) | 1992-02-27 |
CA2065388A1 (en) | 1991-12-29 |
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