WO1997006254A1 - Human mp52 arg protein - Google Patents
Human mp52 arg protein Download PDFInfo
- Publication number
- WO1997006254A1 WO1997006254A1 PCT/EP1996/003427 EP9603427W WO9706254A1 WO 1997006254 A1 WO1997006254 A1 WO 1997006254A1 EP 9603427 W EP9603427 W EP 9603427W WO 9706254 A1 WO9706254 A1 WO 9706254A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bone
- arg
- human
- protein
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9609983A BR9609983A (en) | 1995-08-03 | 1996-08-02 | MP52 human arg proteins |
AU67891/96A AU699708B2 (en) | 1995-08-03 | 1996-08-02 | Human MP52 Arg protein |
PL96324822A PL324822A1 (en) | 1995-08-03 | 1996-08-02 | Human protein mp52 arg |
IL12281796A IL122817A0 (en) | 1995-08-03 | 1996-08-02 | MP 52 ARG protein |
EP96928406A EP0842274A1 (en) | 1995-08-03 | 1996-08-02 | Human mp52 arg protein |
JP09508115A JP2000511155A (en) | 1995-08-03 | 1996-08-02 | Human MP52 Arg protein |
NO980375A NO980375L (en) | 1995-08-03 | 1998-01-28 | Human MP52 Arg protein |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95112241.5 | 1995-08-03 | ||
EP95112241 | 1995-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997006254A1 true WO1997006254A1 (en) | 1997-02-20 |
Family
ID=8219499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/003427 WO1997006254A1 (en) | 1995-08-03 | 1996-08-02 | Human mp52 arg protein |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0842274A1 (en) |
JP (1) | JP2000511155A (en) |
KR (1) | KR19990036081A (en) |
CN (1) | CN1192237A (en) |
AR (1) | AR003974A1 (en) |
AU (1) | AU699708B2 (en) |
BR (1) | BR9609983A (en) |
CA (1) | CA2227204A1 (en) |
HU (1) | HUP9900362A2 (en) |
IL (1) | IL122817A0 (en) |
MX (1) | MX9800801A (en) |
NO (1) | NO980375L (en) |
PL (1) | PL324822A1 (en) |
WO (1) | WO1997006254A1 (en) |
ZA (1) | ZA966489B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6066450A (en) * | 1996-05-16 | 2000-05-23 | Gemini International Holdings Limited | Diagnostic and therapeutic methods and apparatus based on interleukin-6 gene polymorphisms |
US7176284B2 (en) | 1988-04-08 | 2007-02-13 | Stryker Corporation | Osteogenic proteins |
US7253254B1 (en) | 1999-02-13 | 2007-08-07 | Osteopharma Inc. | Polypeptide variants with increased heparin-binding capacity |
WO2012013790A1 (en) | 2010-07-30 | 2012-02-02 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Drug delivery devices and growth factor formulations for accelerated wound healing |
EP2537538A1 (en) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
EP2602264A1 (en) | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | GDF-5 mutant for inducing cartilage formation |
WO2021122545A1 (en) | 2019-12-18 | 2021-06-24 | Merck Patent Gmbh | Use of the gdf-5 mutant for the treatment of pain and cartilage destruction |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101213355B1 (en) * | 2011-12-27 | 2012-12-18 | 오스템임플란트 주식회사 | Dental implant improving initial stability and the method for manufacturing the same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993016099A2 (en) * | 1992-02-12 | 1993-08-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dna sequences encoding novel growth/differentiation factors |
WO1995004819A1 (en) * | 1993-08-10 | 1995-02-16 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | NEW GROWTH/DIFFERENTIATION FACTOR OF THE TGF-β FAMILY |
DE4420157A1 (en) * | 1993-08-10 | 1995-02-23 | Bioph Biotech Entw Pharm Gmbh | New growth / differentiation factor of the TGF-beta family |
WO1995016035A2 (en) * | 1993-12-07 | 1995-06-15 | Genetics Institute, Inc. | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
-
1996
- 1996-07-31 ZA ZA9606489A patent/ZA966489B/en unknown
- 1996-08-01 AR ARP960103838A patent/AR003974A1/en not_active Application Discontinuation
- 1996-08-02 IL IL12281796A patent/IL122817A0/en unknown
- 1996-08-02 WO PCT/EP1996/003427 patent/WO1997006254A1/en not_active Application Discontinuation
- 1996-08-02 KR KR1019980700747A patent/KR19990036081A/en not_active Application Discontinuation
- 1996-08-02 EP EP96928406A patent/EP0842274A1/en not_active Withdrawn
- 1996-08-02 HU HU9900362A patent/HUP9900362A2/en unknown
- 1996-08-02 BR BR9609983A patent/BR9609983A/en not_active Application Discontinuation
- 1996-08-02 CA CA002227204A patent/CA2227204A1/en not_active Abandoned
- 1996-08-02 AU AU67891/96A patent/AU699708B2/en not_active Ceased
- 1996-08-02 PL PL96324822A patent/PL324822A1/en unknown
- 1996-08-02 JP JP09508115A patent/JP2000511155A/en active Pending
- 1996-08-02 CN CN96195841A patent/CN1192237A/en active Pending
-
1998
- 1998-01-28 MX MX9800801A patent/MX9800801A/en unknown
- 1998-01-28 NO NO980375A patent/NO980375L/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993016099A2 (en) * | 1992-02-12 | 1993-08-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dna sequences encoding novel growth/differentiation factors |
WO1995004819A1 (en) * | 1993-08-10 | 1995-02-16 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | NEW GROWTH/DIFFERENTIATION FACTOR OF THE TGF-β FAMILY |
DE4420157A1 (en) * | 1993-08-10 | 1995-02-23 | Bioph Biotech Entw Pharm Gmbh | New growth / differentiation factor of the TGF-beta family |
WO1995016035A2 (en) * | 1993-12-07 | 1995-06-15 | Genetics Institute, Inc. | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
Non-Patent Citations (2)
Title |
---|
ELAINE E. STORM ET AL.: "Limb alterations in brachypodism mice due to mutations in a new member of the TGFbeta-superfamily", NATURE, vol. 368, no. 6472, 14 April 1994 (1994-04-14), LONDON GB, pages 639 - 643, XP002018816 * |
GERTRUD HÖTTEN ET AL.: "Cloning and expression of recombinant human growth/differentiation factor 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 204, no. 2, 28 October 1994 (1994-10-28), ORLANDO, FL US, pages 646 - 652, XP002018817 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7176284B2 (en) | 1988-04-08 | 2007-02-13 | Stryker Corporation | Osteogenic proteins |
US6066450A (en) * | 1996-05-16 | 2000-05-23 | Gemini International Holdings Limited | Diagnostic and therapeutic methods and apparatus based on interleukin-6 gene polymorphisms |
US7253254B1 (en) | 1999-02-13 | 2007-08-07 | Osteopharma Inc. | Polypeptide variants with increased heparin-binding capacity |
WO2012013790A1 (en) | 2010-07-30 | 2012-02-02 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Drug delivery devices and growth factor formulations for accelerated wound healing |
EP2537538A1 (en) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
WO2012175611A1 (en) | 2011-06-22 | 2012-12-27 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Bioresorbable wound dressing |
EP2602264A1 (en) | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | GDF-5 mutant for inducing cartilage formation |
WO2013083649A1 (en) | 2011-12-05 | 2013-06-13 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Gdf-5 mutant for inducing cartilage formation |
EP3168230A1 (en) | 2011-12-05 | 2017-05-17 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka GmbH | Gdf-5 mutant for inducing cartilage formation |
US9718867B2 (en) | 2011-12-05 | 2017-08-01 | Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | GDF-5 mutant for inducing cartilage formation |
WO2021122545A1 (en) | 2019-12-18 | 2021-06-24 | Merck Patent Gmbh | Use of the gdf-5 mutant for the treatment of pain and cartilage destruction |
Also Published As
Publication number | Publication date |
---|---|
CA2227204A1 (en) | 1997-02-20 |
JP2000511155A (en) | 2000-08-29 |
AU699708B2 (en) | 1998-12-10 |
AR003974A1 (en) | 1998-09-30 |
KR19990036081A (en) | 1999-05-25 |
CN1192237A (en) | 1998-09-02 |
NO980375D0 (en) | 1998-01-28 |
PL324822A1 (en) | 1998-06-22 |
NO980375L (en) | 1998-01-28 |
EP0842274A1 (en) | 1998-05-20 |
ZA966489B (en) | 1997-02-26 |
IL122817A0 (en) | 1998-08-16 |
HUP9900362A2 (en) | 1999-05-28 |
AU6789196A (en) | 1997-03-05 |
MX9800801A (en) | 1998-11-29 |
BR9609983A (en) | 1999-01-12 |
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